locus-tag class description HPJ96_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPJ96_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HPJ96_RS00020 ENOG4106C4Y Protein of unknown function (DUF721) HPJ96_RS00030 ENOG4105C0F tryptophanase EC 4.1.99.1 HPJ96_RS00035 ENOG4105C8J )-transporter HPJ96_RS00040 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPJ96_RS00045 ENOG4105EAD ABC transporter HPJ96_RS00060 ENOG4105CIZ coA-substrate-specific enzyme activase HPJ96_RS00295 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HPJ96_RS00300 ENOG4105C34 Pseudouridine synthase HPJ96_RS00305 ENOG4105CIN aminoacyl-histidine dipeptidase HPJ96_RS00310 ENOG4108IUW ABC transporter HPJ96_RS00330 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HPJ96_RS00340 ENOG4108ZVA radical SAM domain protein HPJ96_RS00350 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HPJ96_RS00355 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HPJ96_RS00360 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HPJ96_RS00375 ENOG4105E98 transcriptional regulator DeoR family HPJ96_RS00385 ENOG4105D17 glycoside hydrolase, family 3 domain protein HPJ96_RS00390 ENOG4105CT4 transporter HPJ96_RS00395 ENOG4105CNT hydrolase family 2 HPJ96_RS00400 ENOG4105D2H Uronic isomerase HPJ96_RS00405 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPJ96_RS00415 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPJ96_RS00420 ENOG4105DEI Mannitol dehydrogenase HPJ96_RS00425 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HPJ96_RS00435 ENOG4105II7 pyrroline-5-carboxylate reductase HPJ96_RS00440 ENOG4105F4G Membrane HPJ96_RS00455 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HPJ96_RS00460 ENOG4105VVB HPJ96_RS00465 ENOG4106KG8 HPJ96_RS00470 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HPJ96_RS00475 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HPJ96_RS00485 ENOG4105C0A alcohol dehydrogenase HPJ96_RS00505 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HPJ96_RS00570 ENOG4105C75 arginyL-tRNA synthetase HPJ96_RS00585 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS00590 ENOG4107RFY SbcCD D subunit HPJ96_RS00595 ENOG4105EYH Exonuclease HPJ96_RS00605 ENOG4105C5H ABC transporter HPJ96_RS00610 ENOG4108Z66 YbaK ebsC protein HPJ96_RS00615 ENOG4105CN1 protease HPJ96_RS00620 ENOG4107XZW Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPJ96_RS00635 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HPJ96_RS00650 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HPJ96_RS00665 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPJ96_RS00670 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein HPJ96_RS00680 ENOG4106FP0 HPJ96_RS00695 ENOG4105D1H recombination factor protein RarA HPJ96_RS00705 ENOG4105XBK HPJ96_RS00710 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HPJ96_RS00715 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) HPJ96_RS00725 ENOG4107YVC modification (methylase) HPJ96_RS00735 ENOG4105DFA alanine racemase domain protein HPJ96_RS00750 ENOG4107XF7 NGG1p interacting factor 3 protein, NIF3 HPJ96_RS00755 ENOG410835P This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HPJ96_RS00775 ENOG4105DXN mazG family HPJ96_RS00780 ENOG4106XCQ Inherit from COG: Pfam:DUF82 HPJ96_RS00795 ENOG4105DQ6 Transposase HPJ96_RS00815 ENOG4108Z4J Cytidine monophosphate kinase HPJ96_RS00830 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HPJ96_RS00845 ENOG4105DQ6 Transposase HPJ96_RS00870 ENOG4105DQ6 Transposase HPJ96_RS00890 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HPJ96_RS00900 ENOG4108JE9 extracellular solute-binding protein family 1 HPJ96_RS00915 ENOG4105BZU Histidine kinase HPJ96_RS00920 ENOG4105BZU Histidine kinase HPJ96_RS00940 ENOG4108UHU Aldolase HPJ96_RS00945 ENOG4105C37 (CBS) domain HPJ96_RS00950 ENOG4108JU6 CBS domain protein HPJ96_RS00970 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPJ96_RS00975 ENOG4107V9H nitrite transporter HPJ96_RS00995 ENOG4105ZAM anti-sigma-28 factor flgm family protein HPJ96_RS01000 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HPJ96_RS01010 ENOG4105CSM endonuclease III HPJ96_RS01015 ENOG4105C8J )-transporter HPJ96_RS01020 ENOG4105C0F tryptophanase EC 4.1.99.1 HPJ96_RS01030 ENOG4107QMH DNA methylase HPJ96_RS01035 ENOG4105D8D Type III HPJ96_RS01045 ENOG4105DQ6 Transposase HPJ96_RS01065 ENOG4108DBC nitroreductase HPJ96_RS01070 ENOG4105C3J Cysteine desulfurase HPJ96_RS01075 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HPJ96_RS01105 ENOG4105DAN ATP-dependent protease HPJ96_RS01125 ENOG4105CGH 5'-nucleotidase HPJ96_RS01135 ENOG4105DZW Dipeptidase HPJ96_RS01140 ENOG4105CV8 reductase HPJ96_RS01150 ENOG4105DRR Transcriptional regulator, GntR family HPJ96_RS01170 ENOG4105E0M Sulfatase HPJ96_RS01175 ENOG4105E0M Sulfatase HPJ96_RS01205 ENOG4105D6S protein involved in catabolism of external DNA HPJ96_RS01215 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HPJ96_RS01220 ENOG410854D Required for maturation of 30S ribosomal subunits (By similarity) HPJ96_RS01225 ENOG4105CHV Transcription elongation factor NusA HPJ96_RS01230 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HPJ96_RS01235 ENOG41080JB Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HPJ96_RS01245 ENOG4105DTN riboflavin biosynthesis protein ribF HPJ96_RS01255 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HPJ96_RS01260 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HPJ96_RS01295 ENOG4105DQ6 Transposase HPJ96_RS01300 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HPJ96_RS01310 ENOG4105C22 threonyL-tRNA synthetase HPJ96_RS01315 ENOG4105CB5 ATP-dependent DNA helicase recG HPJ96_RS01320 ENOG4105CGH 5'-nucleotidase HPJ96_RS01330 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPJ96_RS01345 ENOG4105BZ1 (ABC) transporter HPJ96_RS01350 ENOG4105BZ1 (ABC) transporter HPJ96_RS01370 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPJ96_RS01395 ENOG4105G6Z alkaline phosphatase HPJ96_RS01410 ENOG4105EPW hflc protein HPJ96_RS01415 ENOG4107RIZ hflk protein HPJ96_RS01425 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HPJ96_RS01435 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) HPJ96_RS01440 ENOG4106W1H HPJ96_RS01450 ENOG4105CDA abc transporter atp-binding protein HPJ96_RS01455 ENOG4105EAD ABC transporter HPJ96_RS01460 ENOG4108HW3 (ABC) transporter HPJ96_RS01470 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HPJ96_RS01485 ENOG4107S6Z Na H antiporter HPJ96_RS01490 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HPJ96_RS01500 ENOG4105C0D helicase HPJ96_RS01515 ENOG4105KRQ Addiction module toxin, Txe YoeB family HPJ96_RS01525 ENOG4108HU6 Metal dependent phosphohydrolase HPJ96_RS01535 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPJ96_RS01540 ENOG4107XHD Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPJ96_RS01560 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPJ96_RS01570 ENOG4105G9E HPJ96_RS01575 ENOG4108J59 Extracellular solute-binding protein, family 5 HPJ96_RS01580 ENOG4106FRC HPJ96_RS01585 ENOG4105JTB HPJ96_RS01590 ENOG4108V2B Flagellar filament outer layer protein HPJ96_RS01600 ENOG4105D2N Aldolase HPJ96_RS01620 ENOG4107SFZ crispr-associated protein HPJ96_RS01635 ENOG41067MG lrgb family HPJ96_RS01650 ENOG4108ZV0 ABC transporter, permease HPJ96_RS01655 ENOG4108TWB ABC transporter (Permease HPJ96_RS01665 ENOG4108SSC basic membrane HPJ96_RS01680 ENOG41084P6 50S ribosomal protein l28 HPJ96_RS01690 ENOG4105CQ7 ATP-dependent helicase HPJ96_RS01700 ENOG4105C5I Dehydrogenase HPJ96_RS01705 ENOG4105D6U Sodium Glutamate Symporter HPJ96_RS01715 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein HPJ96_RS01720 ENOG4105D9Q decarboxylase (Beta subunit) HPJ96_RS01725 ENOG4105DMN coenzyme A transferase HPJ96_RS01730 ENOG4107UHT Glutaconate CoA-transferase HPJ96_RS01735 ENOG4107QX3 carboxylase HPJ96_RS01740 ENOG4105D6U Sodium Glutamate Symporter HPJ96_RS01750 ENOG4105CMH dehydratase HPJ96_RS01755 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HPJ96_RS01775 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HPJ96_RS01795 ENOG4105C7N Xanthine uracil vitamin C permease HPJ96_RS01800 ENOG4108UIC UPF0340 protein HPJ96_RS01810 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPJ96_RS01830 ENOG41067S9 phage shock protein C, PspC HPJ96_RS01850 ENOG4105CY0 Metallo-Beta-Lactamase HPJ96_RS01855 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPJ96_RS01860 ENOG4108IJ2 phosphate acetyltransferase HPJ96_RS01865 ENOG4107GWN repeat protein HPJ96_RS01870 ENOG4105BZU Histidine kinase HPJ96_RS01880 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HPJ96_RS01890 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HPJ96_RS01895 ENOG4108KS2 transglutaminase domain protein HPJ96_RS01910 ENOG4105C8N cysteinyl-tRNA synthetase HPJ96_RS01915 ENOG4107QWW Cell wall formation (By similarity) HPJ96_RS01920 ENOG4105IJJ transcriptional regulator, crp fnr family HPJ96_RS01935 ENOG4105BZU Histidine kinase HPJ96_RS01940 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HPJ96_RS01960 ENOG4109031 HPJ96_RS01965 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HPJ96_RS02220 ENOG4106VF0 HPJ96_RS02250 ENOG4105EI2 Pseudouridine synthase HPJ96_RS02270 ENOG4105MB2 HPJ96_RS02295 ENOG41085BT Protein of unknown function (DUF1312) HPJ96_RS02300 ENOG4105D78 K07001 NTE family protein HPJ96_RS02315 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HPJ96_RS02320 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS02325 ENOG4105D82 Glutamate dehydrogenase HPJ96_RS02330 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HPJ96_RS02335 ENOG4105CNU cell division protein FtsK HPJ96_RS02345 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HPJ96_RS02395 ENOG4107QP8 phosphohexose isomerase HPJ96_RS02420 ENOG4105BZU Histidine kinase HPJ96_RS02425 ENOG4105WH1 Two component transcriptional regulator luxr family HPJ96_RS02435 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HPJ96_RS02455 ENOG4107QX8 SPFH domain, Band 7 family protein HPJ96_RS02465 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPJ96_RS02475 ENOG4105C9M aspartyl-trna synthetase HPJ96_RS02480 ENOG4107YY3 extracellular solute-binding protein family 1 HPJ96_RS02495 ENOG4105DNX Dna topoisomerase iv (Subunit b) HPJ96_RS02510 ENOG4105CFC Transporter HPJ96_RS02515 ENOG4105C87 Aminotransferase class I and II HPJ96_RS02520 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HPJ96_RS02535 ENOG4108I5U Uridine phosphorylase HPJ96_RS02550 ENOG4105VXR cytoplasmic protein HPJ96_RS02560 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPJ96_RS02565 ENOG4105C3S Mate efflux family protein HPJ96_RS02570 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPJ96_RS02580 ENOG4105C5B carbamate kinase HPJ96_RS02585 ENOG4105DBV ornithine carbamoyltransferase HPJ96_RS02590 ENOG4105CEU Arginine dihydrolase HPJ96_RS02600 ENOG4105C75 arginyL-tRNA synthetase HPJ96_RS02605 ENOG4105C9A Phoh family HPJ96_RS02610 ENOG4105CTJ Metal Dependent Phosphohydrolase HPJ96_RS02615 ENOG41082QW Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HPJ96_RS02620 ENOG4105C37 (CBS) domain HPJ96_RS02645 ENOG4105C10 Electron transfer flavoprotein HPJ96_RS02650 ENOG4105BZJ Electron transfer flavoprotein HPJ96_RS02655 ENOG4105C1G acyl-Coa dehydrogenase HPJ96_RS02660 ENOG4105CEP NADH dehydrogenase HPJ96_RS02675 ENOG4105CMR udp-glucose 4-epimerase HPJ96_RS02690 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPJ96_RS02710 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPJ96_RS02720 ENOG4105C6E dna polymerase iii HPJ96_RS02725 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HPJ96_RS02730 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HPJ96_RS02740 ENOG4107T2D Phosphoribosylaminoimidazolesuccinocarboxamide synthase HPJ96_RS02745 ENOG4107QIK phosphoribosylformylglycinamidine synthase HPJ96_RS02750 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HPJ96_RS02760 ENOG4105CWM branched-chain amino acid transport system II carrier protein HPJ96_RS02765 ENOG4105CHM Aminotransferase HPJ96_RS02770 ENOG4108ZB6 transcriptional regulator AsnC family HPJ96_RS02775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPJ96_RS02785 ENOG4105C4R Atp-dependent dna helicase HPJ96_RS02825 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS02850 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPJ96_RS02855 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS02855 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS02870 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPJ96_RS02895 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPJ96_RS02910 ENOG4107R3N Filamentation induced by cAMP protein fic HPJ96_RS02920 ENOG4105C59 p-type ATPase HPJ96_RS02930 ENOG4105MHT Transcriptional regulator, ARSR family HPJ96_RS02960 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS02970 ENOG4107EFR Flavocytochrome c HPJ96_RS02985 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS03000 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS03030 ENOG41083HS Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HPJ96_RS03035 ENOG4105DFD Na H antiporter HPJ96_RS03085 ENOG4105I03 Flagellin HPJ96_RS03090 ENOG4105C6N Formate acetyltransferase HPJ96_RS03095 ENOG4105F1A Pyruvate formate-lyase HPJ96_RS03115 ENOG4105CBS Chea signal transduction histidine kinase HPJ96_RS03120 ENOG4105YFD chemotaxis, protein HPJ96_RS03130 ENOG4107Z9R response regulator HPJ96_RS03140 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HPJ96_RS03150 ENOG4106GEY HPJ96_RS03155 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPJ96_RS03160 ENOG4106S0F HPJ96_RS03180 ENOG4108RY1 ATP synthase, subunit E HPJ96_RS03190 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) HPJ96_RS03195 ENOG4107RQX Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit HPJ96_RS03200 ENOG4108WBK V-type ATP synthase subunit D HPJ96_RS03205 ENOG4107U1W v-type ATP synthase subunit I HPJ96_RS03215 ENOG4107QNB Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HPJ96_RS03220 ENOG4105WD1 Membrane HPJ96_RS03225 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPJ96_RS03250 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HPJ96_RS03275 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPJ96_RS03280 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPJ96_RS03285 ENOG4108IQE Amp-dependent synthetase and ligase HPJ96_RS03290 ENOG4107R5H iron (metal) dependent repressor, dtxr family HPJ96_RS03295 ENOG4107RBD ABC, transporter HPJ96_RS03300 ENOG4107RPQ ABC transporter HPJ96_RS03305 ENOG4105DIK (ABC) transporter HPJ96_RS03310 ENOG4107SIG periplasmic solute binding protein HPJ96_RS03315 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HPJ96_RS03320 ENOG4105C2J ABC transporter HPJ96_RS03325 ENOG4107R2W ABC transporter, permease HPJ96_RS03545 ENOG4106N2C HPJ96_RS03550 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HPJ96_RS03575 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPJ96_RS03585 ENOG4107QNG Phosphoribosylglycinamide synthetase HPJ96_RS03610 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPJ96_RS03615 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPJ96_RS03620 ENOG4108HM4 ABC transporter HPJ96_RS03625 ENOG4105D38 putrescine abc transporter HPJ96_RS03630 ENOG4105F38 ABC transporter, permease HPJ96_RS03635 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPJ96_RS03640 ENOG4105C5X domain protein HPJ96_RS03650 ENOG41062BZ domain protein HPJ96_RS03660 ENOG4107QW4 alcohol dehydrogenase HPJ96_RS03670 ENOG4105K4H Nlp p60 protein HPJ96_RS03675 ENOG4105CEY Amp-dependent synthetase and ligase HPJ96_RS03680 ENOG41083CW dedA protein HPJ96_RS03685 ENOG4107QMG Nad synthetase HPJ96_RS03695 ENOG410684W HPJ96_RS03700 ENOG4105KG3 cytidine deaminase HPJ96_RS03705 ENOG4105C1A potassium transporter peripheral membrane HPJ96_RS03710 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HPJ96_RS03730 ENOG4108UT2 hemolysin iii HPJ96_RS03750 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS03755 ENOG4108JA2 transcriptioN-repair coupling factor HPJ96_RS03765 ENOG4105CJW magnesium transporter HPJ96_RS03770 ENOG4105D6E homoserine dehydrogenase HPJ96_RS03775 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPJ96_RS03790 ENOG4105DR4 Methyltransferase HPJ96_RS03795 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HPJ96_RS03805 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HPJ96_RS03810 ENOG4108JQ7 (ABC) transporter HPJ96_RS03825 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPJ96_RS03835 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPJ96_RS03840 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HPJ96_RS03855 ENOG4105CKI cobalamin synthesis protein HPJ96_RS03865 ENOG4105E98 transcriptional regulator DeoR family HPJ96_RS03875 ENOG4105D7K pfkb domain protein HPJ96_RS03880 ENOG4105D2N Aldolase HPJ96_RS03885 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HPJ96_RS03890 ENOG4105CI2 imidazolone-5-propionate hydrolase HPJ96_RS03920 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HPJ96_RS03930 ENOG4105C1J atp-dependent rna helicase HPJ96_RS03950 ENOG4105CJ1 ABC, transporter HPJ96_RS03965 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPJ96_RS03975 ENOG4105C2J ABC transporter HPJ96_RS03980 ENOG4105CNN ABC, transporter HPJ96_RS03990 ENOG4105DJ0 Poly(A) Polymerase HPJ96_RS03995 ENOG4105CUY Mechanosensitive ion channel HPJ96_RS04010 ENOG41090KZ HPJ96_RS04035 ENOG4105K6T rare lipoprotein A HPJ96_RS04045 ENOG4105F8V Hydrolase, tatD family HPJ96_RS04050 ENOG41081GK CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyl-transferase HPJ96_RS04055 ENOG4105K63 Thioredoxin HPJ96_RS04060 ENOG4105IJJ transcriptional regulator, crp fnr family HPJ96_RS04080 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPJ96_RS04090 ENOG4107NGC Flagellar filament outer layer protein HPJ96_RS04100 ENOG41086BH Binds directly to 16S ribosomal RNA (By similarity) HPJ96_RS04105 ENOG41083IJ DNA-binding protein HPJ96_RS04110 ENOG4107RI4 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HPJ96_RS04120 ENOG4105CEV competence damage-inducible protein HPJ96_RS04125 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HPJ96_RS04130 ENOG41082DI 50s ribosomal protein l31 HPJ96_RS04145 ENOG4105CA9 Pyruvate kinase HPJ96_RS04160 ENOG4105DRS transport system, permease HPJ96_RS04190 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HPJ96_RS04205 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HPJ96_RS04210 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HPJ96_RS04215 ENOG4108R6K riboflavin synthase, subunit alpha HPJ96_RS04220 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPJ96_RS04235 ENOG4105C5H ABC transporter HPJ96_RS04240 ENOG4105I76 (LipO)protein HPJ96_RS04255 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HPJ96_RS04265 ENOG4107RJF diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90) HPJ96_RS04270 ENOG41082Y9 Single-strand binding protein HPJ96_RS04285 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPJ96_RS04295 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HPJ96_RS04300 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HPJ96_RS04305 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HPJ96_RS04340 ENOG4105D07 Signal peptide peptidase, SppA HPJ96_RS04345 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HPJ96_RS04350 ENOG4105C3F Signal peptidase i HPJ96_RS04360 ENOG4105X1A HPJ96_RS04365 ENOG41062Z1 HPJ96_RS04370 ENOG4105DZP Membrane-associated zinc metalloprotease HPJ96_RS04375 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HPJ96_RS04380 ENOG4105KNE Phosphatidate cytidylyltransferase HPJ96_RS04385 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HPJ96_RS04390 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HPJ96_RS04395 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HPJ96_RS04400 ENOG4105CE9 30S ribosomal protein S2 HPJ96_RS04415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPJ96_RS04425 ENOG4107RBB ABC transporter, permease HPJ96_RS04430 ENOG4105C1J atp-dependent rna helicase HPJ96_RS04435 ENOG4107GGS HPJ96_RS04445 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HPJ96_RS04460 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPJ96_RS04550 ENOG4105KT7 mgtC SapB transporter HPJ96_RS04555 ENOG4106ARS HPJ96_RS04570 ENOG4107R21 site-determining protein HPJ96_RS04580 ENOG4107WGG Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HPJ96_RS04585 ENOG4105DF5 DNA topoisomerase IV, subunit A HPJ96_RS04605 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HPJ96_RS04610 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HPJ96_RS04615 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HPJ96_RS04660 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPJ96_RS04665 ENOG4105F8V Hydrolase, tatD family HPJ96_RS04680 ENOG4108NF7 phage-type endonuclease HPJ96_RS04700 ENOG4108PNI recT protein HPJ96_RS05070 ENOG4105WJX transcriptional regulator MERR family HPJ96_RS05080 ENOG4106QD2 HPJ96_RS05085 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HPJ96_RS05090 ENOG4105C3F Signal peptidase i HPJ96_RS05095 ENOG4105CSA Coproporphyrinogen iii oxidase HPJ96_RS05100 ENOG4106YRG HPJ96_RS05105 ENOG41084AY Binds together with S18 to 16S ribosomal RNA (By similarity) HPJ96_RS05110 ENOG4105Z8H single-stranded DNA-binding protein HPJ96_RS05115 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HPJ96_RS05120 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HPJ96_RS05125 ENOG4105CDU Replicative dna helicase HPJ96_RS05160 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HPJ96_RS05165 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HPJ96_RS05195 ENOG4105DM4 PTS System HPJ96_RS05200 ENOG41077G2 HPJ96_RS05210 ENOG4105MPN Membrane HPJ96_RS05220 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HPJ96_RS05225 ENOG4105CFG Acts as a chaperone (By similarity) HPJ96_RS05230 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HPJ96_RS05235 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) HPJ96_RS05240 ENOG4107RVI Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) HPJ96_RS05260 ENOG4107WUB V-type ATPase 116 kDa subunit HPJ96_RS05275 ENOG4105DM4 PTS System HPJ96_RS05280 ENOG4106447 Preprotein translocase subunit SecG HPJ96_RS05295 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HPJ96_RS05300 ENOG4105DD7 kinase (PfkB family HPJ96_RS05305 ENOG4107YM1 mraZ protein HPJ96_RS05310 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HPJ96_RS05320 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HPJ96_RS05325 ENOG4105CNI cell division protein FtsW HPJ96_RS05330 ENOG410812A polypeptide-transport-associated domain protein, FtsQ-type HPJ96_RS05335 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HPJ96_RS05340 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPJ96_RS05345 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPJ96_RS05355 ENOG4105C79 DNA protecting protein DprA HPJ96_RS05360 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPJ96_RS05365 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPJ96_RS05370 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HPJ96_RS05375 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HPJ96_RS05380 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HPJ96_RS05385 ENOG4108ZC9 flagellar basal-body rod protein flgc HPJ96_RS05395 ENOG4107U2N Flagellar M-ring protein HPJ96_RS05400 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPJ96_RS05405 ENOG4105W2B Flagellar assembly protein HPJ96_RS05410 ENOG4108JIR Flagellum-specific ATP synthase HPJ96_RS05420 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HPJ96_RS05430 ENOG4105Q84 sucrose synthase HPJ96_RS05455 ENOG4105C6F GntR Family Transcriptional Regulator HPJ96_RS05485 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HPJ96_RS05490 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HPJ96_RS05495 ENOG41090QR HPJ96_RS05510 ENOG4105CH2 amidohydrolase HPJ96_RS05525 ENOG4105CSA Coproporphyrinogen iii oxidase HPJ96_RS05535 ENOG4108V1T peptidylprolyl cis-trans isomerase HPJ96_RS05560 ENOG4108RVA ribokinase HPJ96_RS05565 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HPJ96_RS05570 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HPJ96_RS05580 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPJ96_RS05605 ENOG4105W5Q DNA repair protein (RadC HPJ96_RS05635 ENOG4105C0H protease HPJ96_RS05640 ENOG4105CE4 GlcNAc 6-P deacetylase HPJ96_RS05650 ENOG4108IXY short-chain dehydrogenase reductase HPJ96_RS05655 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HPJ96_RS05665 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HPJ96_RS05675 ENOG4107QSA Oxaloacetate decarboxylase HPJ96_RS05680 ENOG4105D9Q decarboxylase (Beta subunit) HPJ96_RS05685 ENOG4105EAB amino acid AbC transporter HPJ96_RS05690 ENOG4108HW3 (ABC) transporter HPJ96_RS05695 ENOG4108120 Pasta domain protein HPJ96_RS05705 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HPJ96_RS05710 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HPJ96_RS05715 ENOG4106BN6 HPJ96_RS05720 ENOG4108JDX DNA polymerase iii, epsilon subunit HPJ96_RS05730 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HPJ96_RS05735 ENOG4106GZE HPJ96_RS05790 ENOG4105CVR type I restriction-modification system HPJ96_RS05815 ENOG4105II7 pyrroline-5-carboxylate reductase HPJ96_RS05830 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HPJ96_RS05835 ENOG4106XJW HPJ96_RS05850 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPJ96_RS05870 ENOG4105CFP Peptidase U32 HPJ96_RS05895 ENOG4107W7Y Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HPJ96_RS05905 ENOG41090Q2 HPJ96_RS05940 ENOG4105WN5 stage II sporulation protein HPJ96_RS05950 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HPJ96_RS05960 ENOG4105K46 50S ribosomal protein l27 HPJ96_RS05965 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HPJ96_RS06015 ENOG4105C19 ABC transporter HPJ96_RS06020 ENOG4107SJW iron permease, FTR1 HPJ96_RS06025 ENOG4108SDV Periplasmic Protein HPJ96_RS06040 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPJ96_RS06055 ENOG4105C19 ABC transporter HPJ96_RS06070 ENOG4105I7V membrAne HPJ96_RS06075 ENOG4105EA8 2-Nitropropane dioxygenase HPJ96_RS06080 ENOG4105ESV Glycosyl transferase, family 4 HPJ96_RS06095 ENOG4105DR5 peptidase HPJ96_RS06105 ENOG4108JQC penicillin-binding protein 1A HPJ96_RS06110 ENOG41082BE ankyrin repeat-containing protein HPJ96_RS06115 ENOG4105Z8J HPJ96_RS06130 ENOG4106AG2 HPJ96_RS06140 ENOG41068FD HPJ96_RS06145 ENOG4105CU9 asparagine synthetase A HPJ96_RS06155 ENOG4108V0P LemA family HPJ96_RS06165 ENOG4105HA9 of methanol dehydrogenase type HPJ96_RS06180 ENOG41061XC HPJ96_RS06195 ENOG4107R3E Citrate transporter HPJ96_RS06200 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HPJ96_RS06215 ENOG4105CGA flagellar basal-body rod protein FlgG HPJ96_RS06220 ENOG4108S3Y transcriptional regulator HPJ96_RS06225 ENOG4105C5Y PTS System HPJ96_RS06230 ENOG4108HCJ Hydrolase HPJ96_RS06235 ENOG4105CS2 ec 3.2.1.21 HPJ96_RS06260 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS06265 ENOG4105MQ3 flagellar protein FliS HPJ96_RS06270 ENOG4106VWR HPJ96_RS06275 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HPJ96_RS06280 ENOG4106B9X HPJ96_RS06285 ENOG4105DR9 pseudouridine synthase HPJ96_RS06290 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HPJ96_RS06295 ENOG4105BZU Histidine kinase HPJ96_RS06320 ENOG41083MR nifu domain-containing protein HPJ96_RS06335 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HPJ96_RS06340 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS06345 ENOG4105BZU Histidine kinase HPJ96_RS06350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPJ96_RS06355 ENOG4108UTW Plays a role in the regulation of phosphate uptake HPJ96_RS06360 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HPJ96_RS06365 ENOG4105E2Z phosphate ABC transporter (Permease HPJ96_RS06370 ENOG4105C8U phosphate abc transporter HPJ96_RS06375 ENOG4105CVA phosphate HPJ96_RS06405 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HPJ96_RS06410 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HPJ96_RS06440 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HPJ96_RS06450 ENOG4105CHY citrate lyase, alpha HPJ96_RS06455 ENOG4105D2K citrate carrier protein HPJ96_RS06470 ENOG4107QMH DNA methylase HPJ96_RS06490 ENOG4108JJB ABC transporter HPJ96_RS06510 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HPJ96_RS06635 ENOG4105NI8 Cytosine-specific methyltransferase HPJ96_RS06745 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPJ96_RS06770 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HPJ96_RS06775 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HPJ96_RS06780 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HPJ96_RS06785 ENOG4105DR5 peptidase HPJ96_RS06790 ENOG4105BZ1 (ABC) transporter HPJ96_RS06795 ENOG4105BZ1 (ABC) transporter HPJ96_RS06800 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HPJ96_RS06815 ENOG4105DQ6 Transposase HPJ96_RS06840 ENOG41062VP HPJ96_RS06855 ENOG4105BZ1 (ABC) transporter HPJ96_RS06860 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HPJ96_RS06865 ENOG41071ED HPJ96_RS06880 ENOG4106UUF HPJ96_RS06895 ENOG4105SXG HPJ96_RS06900 ENOG4105ZF0 Lipoprotein HPJ96_RS06905 ENOG4105C26 Dehydrogenase HPJ96_RS06915 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HPJ96_RS06920 ENOG4105CNN ABC, transporter HPJ96_RS06925 ENOG4105C2J ABC transporter HPJ96_RS06930 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPJ96_RS06955 ENOG4105C6Z Gluconate HPJ96_RS06960 ENOG4105BZW Glycerate kinase HPJ96_RS06965 ENOG4108MIC Mg-protoporphyrin IX methyl transferase HPJ96_RS06970 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HPJ96_RS06975 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HPJ96_RS06990 ENOG4108TSD Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPJ96_RS07005 ENOG4105ZFX HPJ96_RS07045 ENOG4108UW5 maltose o-acetyltransferase HPJ96_RS07055 ENOG4105CTZ aminopeptidase c HPJ96_RS07070 ENOG4105D98 threonine synthase HPJ96_RS07085 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HPJ96_RS07095 ENOG4105K8N protein family UPF0079, ATPase HPJ96_RS07100 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HPJ96_RS07120 ENOG41071ZZ HPJ96_RS07125 ENOG4105KCK Peptidoglycan-associated lipoprotein HPJ96_RS07135 ENOG4105I03 Flagellin HPJ96_RS07140 ENOG4105I03 Flagellin HPJ96_RS07150 ENOG4107VE5 flagellar hook-associated protein HPJ96_RS07155 ENOG4106SAP HPJ96_RS07175 ENOG4105EI2 Pseudouridine synthase HPJ96_RS07185 ENOG41089XN HPJ96_RS07195 ENOG4105C5H ABC transporter HPJ96_RS07195 ENOG4105C5H ABC transporter HPJ96_RS07200 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HPJ96_RS07205 ENOG4105C25 Primosomal protein n' HPJ96_RS07215 ENOG41066A3 ATP guanido phosphotransferase HPJ96_RS07230 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPJ96_RS07245 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HPJ96_RS07250 ENOG4106MPK HPJ96_RS07275 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HPJ96_RS07280 ENOG4108626 Racemase HPJ96_RS07285 ENOG4106PKC pyridoxal phosphate binding HPJ96_RS07295 ENOG4106M0N transport system permease protein HPJ96_RS07300 ENOG4105MUZ Protein of unknown function DUF2620 HPJ96_RS07320 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HPJ96_RS07340 ENOG4105CH2 amidohydrolase HPJ96_RS07350 ENOG4105FAV ABC, transporter HPJ96_RS07355 ENOG4105FDK ABC transporter HPJ96_RS07360 ENOG4105DSE periplasmic solute binding protein HPJ96_RS07375 ENOG4106SUR Protein of unknown function DUF115 HPJ96_RS07385 ENOG4108RAC Rubrerythrin HPJ96_RS07405 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPJ96_RS07415 ENOG4105EJQ L-serine dehydratase HPJ96_RS07420 ENOG4108ESY Metal dependent phosphohydrolase HPJ96_RS07425 ENOG41063XV HPJ96_RS07430 ENOG4107MD5 glycoside hydrolase, family HPJ96_RS07445 ENOG4105CJN penicillin-binding protein HPJ96_RS07455 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HPJ96_RS07470 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HPJ96_RS07475 ENOG41080VC Galactokinase (EC 2.7.1.6) HPJ96_RS07480 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HPJ96_RS07495 ENOG4106R77 HPJ96_RS07505 ENOG4105DR5 peptidase HPJ96_RS07520 ENOG4108NF7 phage-type endonuclease HPJ96_RS07540 ENOG4108PNI recT protein HPJ96_RS07865 ENOG4105DR5 peptidase HPJ96_RS07870 ENOG4105BZ1 (ABC) transporter HPJ96_RS07875 ENOG4105DWF phosphomethylpyrimidine kinase HPJ96_RS07880 ENOG4105C8T Leucyl-tRNA synthetase HPJ96_RS07900 ENOG4106JH4 HPJ96_RS07905 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPJ96_RS07910 ENOG4105DN3 alpha-2-macroglobulin domain protein HPJ96_RS07915 ENOG4108JQB penicillin-binding protein 1C HPJ96_RS07920 ENOG4107QJE Chromosome Partitioning Protein HPJ96_RS07925 ENOG4105FA0 parb-like partition protein HPJ96_RS07935 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPJ96_RS07945 ENOG4105E9H Lytic Murein transglycosylase HPJ96_RS07955 ENOG4106XHX HPJ96_RS07960 ENOG4105MJ2 Competence protein HPJ96_RS07995 ENOG4105WH1 Two component transcriptional regulator luxr family HPJ96_RS08010 ENOG4105BZ8 glutamate synthase HPJ96_RS08015 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein HPJ96_RS08020 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HPJ96_RS08035 ENOG4105E5D amino acid HPJ96_RS08070 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HPJ96_RS08110 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HPJ96_RS08120 ENOG41085YX 50S ribosomal protein L32 HPJ96_RS08125 ENOG41084E5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPJ96_RS08130 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HPJ96_RS08140 ENOG4105F0S class B acid phosphatase HPJ96_RS08150 ENOG4105FE9 pseudouridine synthase HPJ96_RS08155 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HPJ96_RS08160 ENOG4105MBR gumn family HPJ96_RS08165 ENOG4105C31 Tryptophanyl-tRNA synthetase HPJ96_RS08175 ENOG4105CZV ABC transporter HPJ96_RS08185 ENOG4107QJD pyruvate phosphate dikinase HPJ96_RS08190 ENOG4108SXE HPJ96_RS08195 ENOG41073RW Cytoplasmic filament protein A HPJ96_RS08200 ENOG4105YQK von Willebrand factor type A domain HPJ96_RS08210 ENOG4105DK7 lysyl-tRNA synthetase HPJ96_RS08220 ENOG4106C6A Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HPJ96_RS08230 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPJ96_RS08245 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HPJ96_RS08250 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HPJ96_RS08255 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HPJ96_RS08270 ENOG41084ED 50S ribosomal protein L33 HPJ96_RS08280 ENOG4108Z29 Flavodoxin HPJ96_RS08295 ENOG4105CY2 Citrate transporter HPJ96_RS08300 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HPJ96_RS08305 ENOG4108Z7G MaoC domain protein dehydratase HPJ96_RS08515 ENOG4105CEC DNA methylase N-4 N-6 HPJ96_RS08585 ENOG4105M7P phage repressor HPJ96_RS08600 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPJ96_RS08615 ENOG4105KZ7 phosphocarrier protein hpr HPJ96_RS08620 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HPJ96_RS08635 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HPJ96_RS08640 ENOG4107S1W 4-alpha-glucanotransferase HPJ96_RS08650 ENOG4105VG0 50S ribosomal protein l34 HPJ96_RS08665 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HPJ96_RS08680 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) HPJ96_RS08695 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPJ96_RS08700 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HPJ96_RS08710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPJ96_RS08720 ENOG4107RBJ symporter HPJ96_RS08745 ENOG4105C22 threonyL-tRNA synthetase HPJ96_RS08780 ENOG4105DTI Phosphonopyruvate decarboxylase HPJ96_RS08785 ENOG4107STF Involved in phosphonate degradation (By similarity) HPJ96_RS08790 ENOG4105EE0 oxidoreductase HPJ96_RS08820 ENOG4105J5G Transferase hexapeptide repeat containing protein HPJ96_RS08830 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPJ96_RS08835 ENOG4105PSV Polysaccharide Biosynthesis Protein HPJ96_RS08860 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPJ96_RS08865 ENOG4107QQG Dehydrogenase HPJ96_RS08875 ENOG4105DMT epimerase dehydratase HPJ96_RS08895 ENOG4105C1B dTDP-glucose 4-6-dehydratase HPJ96_RS08910 ENOG4105KME endoribonuclease L-psp HPJ96_RS08915 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HPJ96_RS08920 ENOG4105FA0 parb-like partition protein HPJ96_RS08925 ENOG4108QUE repeat-containing protein HPJ96_RS08935 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HPJ96_RS08940 ENOG4105E2D ec 3.2.1.52 HPJ96_RS08945 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPJ96_RS08955 ENOG4106SWD HPJ96_RS08965 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPJ96_RS08985 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HPJ96_RS08990 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HPJ96_RS08995 ENOG41067XK integral membrane protein HPJ96_RS09000 ENOG4105C0B DNA polymerase III (alpha subunit) HPJ96_RS09005 ENOG4105N98 Capsule biosynthesis protein capB HPJ96_RS09020 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPJ96_RS09045 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HPJ96_RS09050 ENOG4106TCE HPJ96_RS09060 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HPJ96_RS09070 ENOG4105W0I repeat-containing protein HPJ96_RS09075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPJ96_RS09080 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HPJ96_RS09095 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HPJ96_RS09100 ENOG4105EAM Na Pi-cotransporter HPJ96_RS09115 ENOG4105FEU K -dependent Na -Ca exchanger HPJ96_RS09125 ENOG41081IW Inherit from COG: Membrane HPJ96_RS09135 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPJ96_RS09140 ENOG4105DUA (citrate (pro-3S)-lyase ligase HPJ96_RS09150 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HPJ96_RS09180 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HPJ96_RS09190 ENOG4105D48 metallophosphoesterase HPJ96_RS09195 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HPJ96_RS09200 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HPJ96_RS09205 ENOG4108RZE Tetr family transcriptional regulator HPJ96_RS09215 ENOG4108M1M outer membrane lipoprotein-sorting protein HPJ96_RS09225 ENOG4108YZY peptidylprolyl cis-trans isomerase HPJ96_RS09235 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HPJ96_RS09240 ENOG410680E Flagellar protein HPJ96_RS09245 ENOG4105CGA flagellar basal-body rod protein FlgG HPJ96_RS09250 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HPJ96_RS09265 ENOG4105C98 muts2 protein HPJ96_RS09270 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HPJ96_RS09285 ENOG4108346 Beta-lactamase domain protein HPJ96_RS09310 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HPJ96_RS09325 ENOG4105CE1 Ferrous iron transport protein b HPJ96_RS09375 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPJ96_RS09380 ENOG4105BZU Histidine kinase HPJ96_RS09385 ENOG4107QRG dna polymerase iii HPJ96_RS09390 ENOG4107JR8 Colicin v production protein HPJ96_RS09395 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HPJ96_RS09415 ENOG4105D48 metallophosphoesterase HPJ96_RS09425 ENOG4105EAH synthase HPJ96_RS09440 ENOG4105HCZ HPJ96_RS09445 ENOG4105CTQ phosphohexokinase HPJ96_RS09450 ENOG4105DQ6 Transposase HPJ96_RS09475 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HPJ96_RS09480 ENOG4105DQ6 Transposase HPJ96_RS09485 ENOG4105DQ6 Transposase HPJ96_RS09495 ENOG4105C5S asparaginyl-tRNA synthetase HPJ96_RS09500 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS09520 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HPJ96_RS09525 ENOG4105W87 Cbs domain HPJ96_RS09530 ENOG4108IV0 ABC, transporter HPJ96_RS09535 ENOG4105C0Z ABC transporter HPJ96_RS09540 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPJ96_RS09545 ENOG4105C32 Amino acid ABC transporter (Permease) HPJ96_RS09555 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HPJ96_RS09560 ENOG41068UM RNA Polymerase HPJ96_RS09570 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS09580 ENOG4106U5D Septum formation initiator HPJ96_RS09585 ENOG410698I HPJ96_RS09595 ENOG4105X4X Protein of unknown function DUF115 HPJ96_RS09600 ENOG41090QV Protein of unknown function DUF115 HPJ96_RS09625 ENOG4105DJV ribulose-phosphate 3-epimerase HPJ96_RS09630 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HPJ96_RS09640 ENOG4105E2D ec 3.2.1.52 HPJ96_RS09645 ENOG4105DZ1 carboxypeptidase HPJ96_RS09655 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HPJ96_RS09700 ENOG4105C9U ATP-dependent DNA helicase RecQ HPJ96_RS09705 ENOG4105DRS transport system, permease HPJ96_RS09710 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HPJ96_RS09740 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPJ96_RS09745 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HPJ96_RS09755 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HPJ96_RS09770 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HPJ96_RS09780 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HPJ96_RS09790 ENOG410805Y Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HPJ96_RS09800 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HPJ96_RS09805 ENOG4107QJQ Mate efflux family protein HPJ96_RS09810 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HPJ96_RS09825 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HPJ96_RS09835 ENOG4108JQ7 (ABC) transporter HPJ96_RS09845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPJ96_RS09850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPJ96_RS09855 ENOG4107QSI ABC, transporter HPJ96_RS09860 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HPJ96_RS09865 ENOG410841Q phosphoesterase PA-phosphatase related protein HPJ96_RS09880 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPJ96_RS09885 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HPJ96_RS09890 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPJ96_RS09895 ENOG4105YFD chemotaxis, protein HPJ96_RS09905 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS09925 ENOG4105EMN RNA polymerase sigma factor HPJ96_RS09940 ENOG4105EHZ conserved protein UCP016719 HPJ96_RS09950 ENOG4105CZN Potassium uptake protein HPJ96_RS09955 ENOG4107ZYR domain protein HPJ96_RS09970 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPJ96_RS09985 ENOG4105WN5 stage II sporulation protein HPJ96_RS10005 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HPJ96_RS10010 ENOG4105BZ1 (ABC) transporter HPJ96_RS10015 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HPJ96_RS10020 ENOG4105C7B Threonine dehydratase HPJ96_RS10025 ENOG4105C28 cystathionine HPJ96_RS10030 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HPJ96_RS10035 ENOG4105C84 Histidine ammonia-lyase HPJ96_RS10040 ENOG4105C94 Transporter HPJ96_RS10050 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HPJ96_RS10060 ENOG4105CKB glycosidase HPJ96_RS10080 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HPJ96_RS10090 ENOG4105CEM UPF0597 protein HPJ96_RS10100 ENOG4108KP7 hydrolase HPJ96_RS10105 ENOG4105T73 HPJ96_RS10110 ENOG4105C8J )-transporter HPJ96_RS10115 ENOG4105C4R Atp-dependent dna helicase HPJ96_RS10125 ENOG4105TQV HPJ96_RS10160 ENOG4105CPI Metal Dependent Phosphohydrolase HPJ96_RS10165 ENOG4105D00 flagellar biosynthetic protein flhB HPJ96_RS10175 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HPJ96_RS10180 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HPJ96_RS10185 ENOG4107GQ3 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HPJ96_RS10190 ENOG4105VB6 UPF0109 protein HPJ96_RS10195 ENOG4105K5M 30s ribosomal protein S16 HPJ96_RS10220 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPJ96_RS10225 ENOG41067SE Tetr family transcriptional regulator HPJ96_RS10235 ENOG4105BZ1 (ABC) transporter HPJ96_RS10250 ENOG4105CBX hi0933 family HPJ96_RS10255 ENOG4107EFR Flavocytochrome c HPJ96_RS10260 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HPJ96_RS10265 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HPJ96_RS10320 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPJ96_RS10330 ENOG4105UIB (ABC) transporter HPJ96_RS10335 ENOG4108JQ9 ABC transporter HPJ96_RS10340 ENOG4107TFB basic membrane HPJ96_RS10350 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPJ96_RS10365 ENOG41073FS HPJ96_RS10375 ENOG4108RCM Nitroreductase HPJ96_RS10385 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS10420 ENOG4105D7A ATP-binding protein HPJ96_RS10440 ENOG4106UV5 membrane protein A HPJ96_RS10450 ENOG4105CFP Peptidase U32 HPJ96_RS10455 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPJ96_RS10460 ENOG4107Z25 Basic membrane protein HPJ96_RS10485 ENOG4105BZA Phosphoglycerate kinase HPJ96_RS10490 ENOG4105CP7 Triose-phosphate isomerase HPJ96_RS10505 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HPJ96_RS10510 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HPJ96_RS10530 ENOG4105VUF Transcriptional regulator HPJ96_RS10555 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HPJ96_RS10560 ENOG4105D6U Sodium Glutamate Symporter HPJ96_RS10575 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS10630 ENOG4105WH1 Two component transcriptional regulator luxr family HPJ96_RS10635 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPJ96_RS10655 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPJ96_RS10665 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPJ96_RS10690 ENOG4107V28 uracil phosphoribosyltransferase HPJ96_RS10700 ENOG4105C9U ATP-dependent DNA helicase RecQ HPJ96_RS10705 ENOG4107SJN Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HPJ96_RS10710 ENOG4105K4W Could be involved in septation (By similarity) HPJ96_RS10720 ENOG4107TVT This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HPJ96_RS10725 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HPJ96_RS10730 ENOG41069X2 HPJ96_RS10740 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HPJ96_RS10760 ENOG4105CM4 permease protein HPJ96_RS10765 ENOG4108IPW abc transporter atp-binding protein HPJ96_RS10770 ENOG4107QKZ Ompa motb domain protein HPJ96_RS10830 ENOG4105Z8H single-stranded DNA-binding protein HPJ96_RS11095 ENOG4107W93 Dihydroorotate dehydrogenase HPJ96_RS11100 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HPJ96_RS11110 ENOG4105DVT helicase HPJ96_RS11115 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPJ96_RS11120 ENOG4105DC7 peptidase M24 HPJ96_RS11130 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HPJ96_RS11145 ENOG4105G3C Type iv pilus assembly HPJ96_RS11170 ENOG4105DVC DnaJ domain protein HPJ96_RS11175 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPJ96_RS11185 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPJ96_RS11200 ENOG4106TP1 HPJ96_RS11210 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HPJ96_RS11220 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HPJ96_RS11225 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit HPJ96_RS11230 ENOG4105DGN Electron transport complex HPJ96_RS11235 ENOG4105DZB Electron transport complex HPJ96_RS11245 ENOG4105D6A Electron transport complex HPJ96_RS11250 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HPJ96_RS11270 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HPJ96_RS11280 ENOG4105HHA aminodeoxychorismate lyase HPJ96_RS11285 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HPJ96_RS11290 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPJ96_RS11310 ENOG4105DFF Rod shape-determining protein mreb HPJ96_RS11325 ENOG4105CJN penicillin-binding protein HPJ96_RS11330 ENOG4105CNI cell division protein FtsW HPJ96_RS11335 ENOG4105EIB trna rrna methyltransferase HPJ96_RS11345 ENOG4105C3J Cysteine desulfurase HPJ96_RS11360 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HPJ96_RS11365 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HPJ96_RS11370 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HPJ96_RS11380 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPJ96_RS11385 ENOG4105E0C molybdate abc transporter HPJ96_RS11390 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPJ96_RS11400 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPJ96_RS11415 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPJ96_RS11420 ENOG4105CEV competence damage-inducible protein HPJ96_RS11425 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HPJ96_RS11430 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HPJ96_RS11440 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HPJ96_RS11445 ENOG4105BZ8 glutamate synthase HPJ96_RS11450 ENOG4107RCH Diaminopropionate ammonia-lyase HPJ96_RS11455 ENOG4107S4Y M20 DapE family protein YgeY HPJ96_RS11460 ENOG4105IW6 Carbamoyltransferase HPJ96_RS11480 ENOG410908R Methenyltetrahydrofolate cyclohydrolase HPJ96_RS11485 ENOG4105CKU formyltetrahydrofolate synthetase HPJ96_RS11490 ENOG4105CCS Glutamate formiminotransferase HPJ96_RS11495 ENOG4105C84 Histidine ammonia-lyase HPJ96_RS11500 ENOG4105D3Y Na H antiporter HPJ96_RS11510 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HPJ96_RS11515 ENOG4105EEI dihydropteroate synthase HPJ96_RS11520 ENOG4105C8B TIGR00159 family HPJ96_RS11535 ENOG4108CER Uncharacterized protein conserved in bacteria (DUF2225) HPJ96_RS11540 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HPJ96_RS11545 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HPJ96_RS11560 ENOG4105E39 Enoyl-CoA hydratase HPJ96_RS11565 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPJ96_RS11570 ENOG4105CNW domain protein HPJ96_RS11575 ENOG4105C1G acyl-Coa dehydrogenase HPJ96_RS11580 ENOG4105CHU acetyl-coa acetyltransferase HPJ96_RS11590 ENOG4105C5Y PTS System HPJ96_RS11595 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HPJ96_RS11600 ENOG4105CGK Exodeoxyribonuclease III HPJ96_RS11610 ENOG4105VEM Conserved domain protein HPJ96_RS11615 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPJ96_RS11620 ENOG4108JJ8 (ABC) transporter HPJ96_RS11625 ENOG4108JJ9 ABC, transporter HPJ96_RS11630 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPJ96_RS11635 ENOG4105C4M (Ubiquinol oxidase) subunit I HPJ96_RS11700 ENOG4108Y51 tRNA-binding protein HPJ96_RS11705 ENOG4105CJR Integral membrane protein (MviN HPJ96_RS11725 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HPJ96_RS11730 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPJ96_RS11735 ENOG4105CUT histidyl-tRNA synthetase HPJ96_RS11740 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HPJ96_RS11745 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPJ96_RS11755 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPJ96_RS11775 ENOG4106RHC HPJ96_RS11780 ENOG4108PJD permease HPJ96_RS11790 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HPJ96_RS11820 ENOG4108IUZ ABC transporter HPJ96_RS11825 ENOG4105BZ1 (ABC) transporter HPJ96_RS11830 ENOG4108JJ9 ABC, transporter HPJ96_RS11840 ENOG4106N3A copper homeostasis protein cutc HPJ96_RS11845 ENOG4105CHJ isochorismatase hydrolase HPJ96_RS11915 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HPJ96_RS11960 ENOG4106TEA HPJ96_RS11995 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HPJ96_RS12000 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HPJ96_RS12010 ENOG4105DFM M18 family aminopeptidase HPJ96_RS12025 ENOG4107I03 HPJ96_RS12050 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HPJ96_RS12065 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS12080 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HPJ96_RS12090 ENOG4108UQV Membrane HPJ96_RS12105 ENOG4105CAH Chromate HPJ96_RS12120 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPJ96_RS12125 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HPJ96_RS12130 ENOG4105C26 Dehydrogenase HPJ96_RS12140 ENOG4108JQ1 Dehydrogenase HPJ96_RS12165 ENOG4105K95 (LipO)protein HPJ96_RS12175 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HPJ96_RS12185 ENOG4106AHS HPJ96_RS12190 ENOG4107QIV Cytochrome c biogenesis protein HPJ96_RS12195 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPJ96_RS12225 ENOG4105DM4 PTS System HPJ96_RS12230 ENOG4105DE4 1-phosphofructokinase HPJ96_RS12235 ENOG4105E98 transcriptional regulator DeoR family HPJ96_RS12240 ENOG4105D3R alkyl hydroperoxide reductase HPJ96_RS12255 ENOG4105D17 glycoside hydrolase, family 3 domain protein HPJ96_RS12260 ENOG4105C3M thioredoxin reductase HPJ96_RS12280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPJ96_RS12290 ENOG4108JQ7 (ABC) transporter HPJ96_RS12300 ENOG4105BZ1 (ABC) transporter HPJ96_RS12305 ENOG4105BZ1 (ABC) transporter HPJ96_RS12310 ENOG4105BZ1 (ABC) transporter HPJ96_RS12315 ENOG4105BZ1 (ABC) transporter HPJ96_RS12325 ENOG4105CPF Cell wall formation (By similarity) HPJ96_RS12355 ENOG4105D7X high-affinity nickel-transporter HPJ96_RS12370 ENOG4105DQ6 Transposase HPJ96_RS12380 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HPJ96_RS12385 ENOG4108IUS Transketolase HPJ96_RS12390 ENOG4108HHA Transketolase HPJ96_RS12410 ENOG4108JJB ABC transporter HPJ96_RS12415 ENOG4105VKD bioY protein HPJ96_RS12420 ENOG4105C3G gtp-binding protein HPJ96_RS12425 ENOG4105CTQ phosphohexokinase HPJ96_RS12435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPJ96_RS12455 ENOG4105CJ2 (LipO)protein HPJ96_RS12510 ENOG410600T transposase HPJ96_RS12640 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HPJ96_RS12740 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPJ96_RS12830 ENOG4105CMT Dihydroxyacetone kinase HPJ96_RS12865 ENOG4108JJB ABC transporter HPJ96_RS12885 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPJ96_RS12905 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HPJ96_RS12910 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HPJ96_RS12945 ENOG4105NBF ammecr1 domain protein HPJ96_RS12950 ENOG4108IQE Amp-dependent synthetase and ligase HPJ96_RS12970 ENOG4105RJI HPJ96_RS12975 ENOG410877G HPJ96_RS12980 ENOG4108TVT permease HPJ96_RS12990 ENOG4105CDY transcriptional regulatory protein HPJ96_RS13000 ENOG4105CXB phosphoribosylaminoimidazole synthetase HPJ96_RS13005 ENOG4108V3E phosphoribosylglycinamide formyltransferase HPJ96_RS13010 ENOG4105C8Q Methyl-accepting chemotaxis HPJ96_RS13025 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPJ96_RS13030 ENOG4107RCV ABC transporter, permease HPJ96_RS13045 ENOG4105CUZ uba thif-type nad fad binding protein HPJ96_RS13145 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HPJ96_RS13175 ENOG4105C2M dna polymerase I HPJ96_RS13195 ENOG4105FB2 class II Aldolase HPJ96_RS13200 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HPJ96_RS13205 ENOG4105E98 transcriptional regulator DeoR family HPJ96_RS13210 ENOG4105CTS PTS system mannitol-specific HPJ96_RS13215 ENOG4105E0Y RtcB Protein HPJ96_RS13220 ENOG4105DPN Oligoendopeptidase f HPJ96_RS13235 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HPJ96_RS13245 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HPJ96_RS13265 ENOG410822I Flagellar hook capping protein HPJ96_RS13270 ENOG4105BZE flagellar hook protein, FlgE HPJ96_RS13280 ENOG4107R0U MotA TolQ exbB proton channel HPJ96_RS13285 ENOG4107XSU flagellar motor protein motb HPJ96_RS13290 ENOG41064SM flagellar basal body-associated protein flil HPJ96_RS13295 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPJ96_RS13300 ENOG4105DD5 Flagellar motor switch protein HPJ96_RS13310 ENOG4105CN7 Flagellar biosynthetic protein FliP HPJ96_RS13315 ENOG4105VS8 Flagellar biosynthetic protein fliq HPJ96_RS13320 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HPJ96_RS13325 ENOG4105D00 flagellar biosynthetic protein flhB HPJ96_RS13330 ENOG4105D7B Flagellar biosynthesis protein flha HPJ96_RS13335 ENOG4105FZW flagellar biosynthesis regulator FlhF HPJ96_RS13345 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HPJ96_RS13350 ENOG41082MQ UPF0178 protein HPJ96_RS13355 ENOG4105EIP mannose-6-phosphate isomerase HPJ96_RS13360 ENOG4106BMT Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HPJ96_RS13370 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HPJ96_RS13385 ENOG4105C0H protease HPJ96_RS13390 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPJ96_RS13405 ENOG41083NY Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HPJ96_RS13410 ENOG4105E66 phosphoriboisomerase A HPJ96_RS13415 ENOG4107YNV 3-dehydroquinate dehydratase HPJ96_RS13430 ENOG4105DAP Nicotinate phosphoribosyltransferase HPJ96_RS13440 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HPJ96_RS13445 ENOG4105DR5 peptidase HPJ96_RS13460 ENOG4105MA4 psp1 domain protein HPJ96_RS13490 ENOG4105DCI Phosphohydrolase HPJ96_RS13495 ENOG4105MAX Superoxide reductase HPJ96_RS13500 ENOG4108I7Y domain protein HPJ96_RS13510 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HPJ96_RS13515 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HPJ96_RS13520 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HPJ96_RS13525 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HPJ96_RS13530 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HPJ96_RS13535 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HPJ96_RS13545 ENOG41082G4 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HPJ96_RS13550 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HPJ96_RS13560 ENOG41086S0 50s ribosomal protein l29 HPJ96_RS13565 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HPJ96_RS13580 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HPJ96_RS13590 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HPJ96_RS13595 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HPJ96_RS13600 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HPJ96_RS13610 ENOG41084HK 50S ribosomal protein L30 HPJ96_RS13615 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HPJ96_RS13620 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPJ96_RS13625 ENOG41067V7 50S ribosomal protein L36 HPJ96_RS13635 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HPJ96_RS13640 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPJ96_RS13645 ENOG4108ZT0 50S ribosomal protein l17 HPJ96_RS13650 ENOG4106DC9 HPJ96_RS13670 ENOG4109015 Biopolymer transport protein exbD tolR HPJ96_RS13680 ENOG4105E6M Sulphatase-modifying factor protein HPJ96_RS13700 ENOG4105CNN ABC, transporter HPJ96_RS13705 ENOG4105CNN ABC, transporter HPJ96_RS13735 ENOG4105DIW FeS assembly protein SUFB HPJ96_RS13745 ENOG4105C9B Cysteine desulfurase HPJ96_RS13750 ENOG4107YH3 SUF system FeS assembly protein, NifU family HPJ96_RS13760 ENOG41088SP formiminoglutamate hydrolase HPJ96_RS13770 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPJ96_RS13780 ENOG4105HFZ Membrane HPJ96_RS13790 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPJ96_RS13800 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HPJ96_RS13810 ENOG4108JJB ABC transporter HPJ96_RS13815 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HPJ96_RS13820 ENOG4108IG5 Transcriptional regulator HPJ96_RS13825 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HPJ96_RS13835 ENOG4108UVJ appr-1-p processing domain protein HPJ96_RS13850 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HPJ96_RS13855 ENOG4108UMN azlc family HPJ96_RS13860 ENOG4105KMT branched-chain amino acid