locus-tag	class	description
HPJ96_RS00010	COG0592	DNA-directed DNA polymerase activity
HPJ96_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPJ96_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HPJ96_RS00035	COG0733	neurotransmitter:sodium symporter activity
HPJ96_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPJ96_RS00045	COG0765	amino acid transport
HPJ96_RS00060	COG1924	4 iron, 4 sulfur cluster binding
HPJ96_RS00295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPJ96_RS00300	COG0564	pseudouridine synthase activity
HPJ96_RS00305	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPJ96_RS00310	COG4555	ABC transporter
HPJ96_RS00330	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPJ96_RS00340	COG0731	radical SAM domain protein
HPJ96_RS00350	COG0423	glycine-tRNA ligase activity
HPJ96_RS00355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPJ96_RS00375	COG1349	DNA-binding transcription factor activity
HPJ96_RS00390	COG2211	Major facilitator Superfamily
HPJ96_RS00395	COG3250	beta-galactosidase activity
HPJ96_RS00400	COG1904	glucuronate isomerase
HPJ96_RS00420	COG0246	Mannitol dehydrogenase
HPJ96_RS00425	COG1312	Catalyzes the dehydration of D-mannonate
HPJ96_RS00435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPJ96_RS00440	COG0628	permease
HPJ96_RS00455	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPJ96_RS00470	COG0442	prolyl-tRNA aminoacylation
HPJ96_RS00475	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HPJ96_RS00485	COG1454	alcohol dehydrogenase
HPJ96_RS00485	COG1012	belongs to the aldehyde dehydrogenase family
HPJ96_RS00505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPJ96_RS00520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPJ96_RS00520	COG1747	RNA polymerase binding
HPJ96_RS00530	COG2183	response to ionizing radiation
HPJ96_RS00570	COG0018	arginyl-trna synthetase
HPJ96_RS00585	COG0840	transmembrane signaling receptor activity
HPJ96_RS00590	COG0420	3'-5' exonuclease activity
HPJ96_RS00595	COG0419	ATPase involved in DNA repair
HPJ96_RS00605	COG0488	(ABC) transporter
HPJ96_RS00610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPJ96_RS00615	COG0793	Belongs to the peptidase S41A family
HPJ96_RS00620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPJ96_RS00635	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HPJ96_RS00650	COG0673	inositol 2-dehydrogenase activity
HPJ96_RS00665	COG1191	sigma factor activity
HPJ96_RS00670	COG1847	R3H domain protein
HPJ96_RS00695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPJ96_RS00710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPJ96_RS00715	COG1469	GTP cyclohydrolase I activity
HPJ96_RS00725	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HPJ96_RS00735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPJ96_RS00750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPJ96_RS00755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPJ96_RS00775	COG3956	TIGRFAM MazG family protein
HPJ96_RS00795	COG2801	Transposase and inactivated derivatives
HPJ96_RS00815	COG1102	Psort location Cytoplasmic, score
HPJ96_RS00830	COG0556	nucleotide-excision repair
HPJ96_RS00845	COG2801	Transposase and inactivated derivatives
HPJ96_RS00870	COG2801	Transposase and inactivated derivatives
HPJ96_RS00890	COG0395	ABC-type sugar transport system, permease component
HPJ96_RS00900	COG1653	transport
HPJ96_RS00915	COG3706	GGDEF domain
HPJ96_RS00920	COG3706	GGDEF domain
HPJ96_RS00940	COG0800	Aldolase
HPJ96_RS00945	COG1253	flavin adenine dinucleotide binding
HPJ96_RS00950	COG4536	flavin adenine dinucleotide binding
HPJ96_RS00970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPJ96_RS00975	COG2116	formate transmembrane transporter activity
HPJ96_RS01000	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPJ96_RS01010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPJ96_RS01015	COG0733	neurotransmitter:sodium symporter activity
HPJ96_RS01045	COG2801	Transposase and inactivated derivatives
HPJ96_RS01065	COG0778	Nitroreductase
HPJ96_RS01070	COG1104	cysteine desulfurase activity
HPJ96_RS01075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPJ96_RS01075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPJ96_RS01105	COG1067	ATP-dependent peptidase activity
HPJ96_RS01125	COG0737	Belongs to the 5'-nucleotidase family
HPJ96_RS01130	COG3842	ATPase activity
HPJ96_RS01140	COG0656	L-ascorbic acid biosynthetic process
HPJ96_RS01150	COG1802	Transcriptional regulator
HPJ96_RS01170	COG1368	sulfuric ester hydrolase activity
HPJ96_RS01175	COG1368	sulfuric ester hydrolase activity
HPJ96_RS01205	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPJ96_RS01215	COG0343	queuine tRNA-ribosyltransferase activity
HPJ96_RS01220	COG0779	Required for maturation of 30S ribosomal subunits
HPJ96_RS01230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPJ96_RS01235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPJ96_RS01245	COG0196	riboflavin kinase activity
HPJ96_RS01255	COG1185	polyribonucleotide nucleotidyltransferase activity
HPJ96_RS01260	COG0756	dUTP diphosphatase activity
HPJ96_RS01295	COG2801	Transposase and inactivated derivatives
HPJ96_RS01300	COG2095	MarC family integral membrane protein
HPJ96_RS01310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPJ96_RS01315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPJ96_RS01320	COG0737	Belongs to the 5'-nucleotidase family
HPJ96_RS01330	COG0525	valine-tRNA ligase activity
HPJ96_RS01345	COG1132	(ABC) transporter
HPJ96_RS01350	COG1132	(ABC) transporter
HPJ96_RS01370	COG1136	(ABC) transporter
HPJ96_RS01395	COG1785	Belongs to the alkaline phosphatase family
HPJ96_RS01410	COG0330	HflC and HflK could
HPJ96_RS01415	COG0330	HflC and HflK could
HPJ96_RS01425	COG1175	transmembrane transport
HPJ96_RS01435	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HPJ96_RS01450	COG1126	abc transporter atp-binding protein
HPJ96_RS01455	COG0765	amino acid transport
HPJ96_RS01460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPJ96_RS01470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPJ96_RS01485	COG1757	Na H antiporter
HPJ96_RS01490	COG0504	CTP synthase activity
HPJ96_RS01500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPJ96_RS01515	COG4115	mRNA cleavage
HPJ96_RS01525	COG1639	'signal transduction protein
HPJ96_RS01530	COG1862	Preprotein translocase
HPJ96_RS01535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPJ96_RS01540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPJ96_RS01560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPJ96_RS01575	COG4166	transmembrane transport
HPJ96_RS01600	COG0191	fructose-bisphosphate aldolase activity
HPJ96_RS01620	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HPJ96_RS01635	COG1346	cytolysis
HPJ96_RS01650	COG1079	Belongs to the binding-protein-dependent transport system permease family
HPJ96_RS01655	COG4603	Belongs to the binding-protein-dependent transport system permease family
HPJ96_RS01660	COG3845	ABC transporter
HPJ96_RS01665	COG1744	ABC transporter substrate-binding protein PnrA-like
HPJ96_RS01680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPJ96_RS01700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPJ96_RS01705	COG0786	glutamate:sodium symporter activity
HPJ96_RS01715	COG4770	biotin carboxylase activity
HPJ96_RS01720	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HPJ96_RS01725	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPJ96_RS01730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPJ96_RS01735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPJ96_RS01740	COG0786	glutamate:sodium symporter activity
HPJ96_RS01750	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HPJ96_RS01755	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HPJ96_RS01765	COG4209	transmembrane transport
HPJ96_RS01775	COG0395	ABC-type sugar transport system, permease component
HPJ96_RS01795	COG2252	PERMEase
HPJ96_RS01800	COG4475	Protein of unknown function (DUF436)
HPJ96_RS01810	COG0840	transmembrane signaling receptor activity
HPJ96_RS01830	COG1983	PspC domain protein
HPJ96_RS01850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPJ96_RS01855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPJ96_RS01860	COG0280	phosphate acetyltransferase
HPJ96_RS01865	COG0457	Tetratricopeptide repeat
HPJ96_RS01870	COG0784	Response regulator, receiver
HPJ96_RS01870	COG5002	protein histidine kinase activity
HPJ96_RS01870	COG2205	protein histidine kinase activity
HPJ96_RS01875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPJ96_RS01880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPJ96_RS01890	COG0528	UMP kinase activity
HPJ96_RS01895	COG1305	Transglutaminase-like
HPJ96_RS01910	COG0215	cysteine-tRNA ligase activity
HPJ96_RS01915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPJ96_RS01920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPJ96_RS01940	COG2201	protein-glutamate methylesterase activity
HPJ96_RS01960	COG2887	Belongs to the helicase family. UvrD subfamily
HPJ96_RS01965	COG1074	ATP-dependent DNA helicase activity
HPJ96_RS02250	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPJ96_RS02250	COG0564	pseudouridine synthase activity
HPJ96_RS02270	COG0823	Involved in the tonB-independent uptake of proteins
HPJ96_RS02295	COG5341	Protein conserved in bacteria
HPJ96_RS02300	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPJ96_RS02305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPJ96_RS02320	COG0840	transmembrane signaling receptor activity
HPJ96_RS02330	COG1968	undecaprenyl-diphosphatase activity
HPJ96_RS02335	COG1674	ftsk spoiiie
HPJ96_RS02345	COG0482	sulfurtransferase activity
HPJ96_RS02395	COG0166	Belongs to the GPI family
HPJ96_RS02420	COG4585	Histidine kinase
HPJ96_RS02425	COG2197	response regulator
HPJ96_RS02435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPJ96_RS02455	COG0330	HflC and HflK could
HPJ96_RS02465	COG2084	Dehydrogenase
HPJ96_RS02475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPJ96_RS02480	COG1653	transport
HPJ96_RS02490	COG0395	ABC-type sugar transport system, permease component
HPJ96_RS02510	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPJ96_RS02515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPJ96_RS02520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPJ96_RS02525	COG1722	exodeoxyribonuclease VII activity
HPJ96_RS02530	COG1966	Carbon starvation protein
HPJ96_RS02535	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPJ96_RS02560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPJ96_RS02565	COG0534	Mate efflux family protein
HPJ96_RS02570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPJ96_RS02580	COG0549	Belongs to the carbamate kinase family
HPJ96_RS02585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPJ96_RS02590	COG2235	arginine
HPJ96_RS02600	COG0018	arginyl-trna synthetase
HPJ96_RS02605	COG1702	phosphate starvation-inducible protein PhoH
HPJ96_RS02610	COG1480	7TM receptor with intracellular HD hydrolase
HPJ96_RS02615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPJ96_RS02645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPJ96_RS02650	COG2086	electron transfer activity
HPJ96_RS02655	COG1960	acyl-CoA dehydrogenase activity
HPJ96_RS02660	COG1252	NADH dehydrogenase
HPJ96_RS02675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPJ96_RS02690	COG0840	transmembrane signaling receptor activity
HPJ96_RS02695	COG0655	NAD(P)H dehydrogenase (quinone) activity
HPJ96_RS02720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPJ96_RS02725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPJ96_RS02730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPJ96_RS02745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPJ96_RS02750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPJ96_RS02755	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPJ96_RS02760	COG1114	Component of the transport system for branched-chain amino acids
HPJ96_RS02765	COG0436	Aminotransferase
HPJ96_RS02770	COG1522	sequence-specific DNA binding
HPJ96_RS02775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPJ96_RS02785	COG0210	DNA helicase
HPJ96_RS02820	COG3385	transposase activity
HPJ96_RS02850	COG0840	transmembrane signaling receptor activity
HPJ96_RS02855	COG0840	transmembrane signaling receptor activity
HPJ96_RS02855	COG0840	transmembrane signaling receptor activity
HPJ96_RS02870	COG0840	transmembrane signaling receptor activity
HPJ96_RS02895	COG0840	transmembrane signaling receptor activity
HPJ96_RS02900	COG3385	transposase activity
HPJ96_RS02910	COG3177	Filamentation induced by cAMP protein fic
HPJ96_RS02920	COG2217	Heavy metal translocating P-type atpase
HPJ96_RS02930	COG0640	Transcriptional regulator
HPJ96_RS02970	COG0431	NADPH-dependent FMN reductase
HPJ96_RS02970	COG1053	succinate dehydrogenase
HPJ96_RS02970	COG3976	FMN-binding domain protein
HPJ96_RS03000	COG0840	transmembrane signaling receptor activity
HPJ96_RS03030	COG0357	Ribosomal RNA small subunit methyltransferase G
HPJ96_RS03035	COG1757	Na H antiporter
HPJ96_RS03075	COG1253	flavin adenine dinucleotide binding
HPJ96_RS03090	COG1882	Formate acetyltransferase
HPJ96_RS03095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPJ96_RS03115	COG0643	Histidine kinase
HPJ96_RS03115	COG2198	Histidine kinase
HPJ96_RS03120	COG0835	chemotaxis
HPJ96_RS03130	COG2201	protein-glutamate methylesterase activity
HPJ96_RS03140	COG1196	nuclear chromosome segregation
HPJ96_RS03150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPJ96_RS03155	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPJ96_RS03180	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HPJ96_RS03190	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HPJ96_RS03195	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HPJ96_RS03200	COG1394	ATPase activity, coupled to movement of substances
HPJ96_RS03205	COG1269	ATP hydrolysis coupled proton transport
HPJ96_RS03215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HPJ96_RS03220	COG2832	Protein of unknown function (DUF454)
HPJ96_RS03225	COG0285	dihydrofolate synthase activity
HPJ96_RS03250	COG2333	competence protein COMEC
HPJ96_RS03250	COG0658	competence protein
HPJ96_RS03275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPJ96_RS03280	COG2890	protein-(glutamine-N5) methyltransferase activity
HPJ96_RS03285	COG1022	Amp-dependent synthetase and ligase
HPJ96_RS03290	COG1321	iron dependent repressor
HPJ96_RS03295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPJ96_RS03300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPJ96_RS03305	COG1121	(ABC) transporter
HPJ96_RS03310	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPJ96_RS03315	COG1879	ABC-type sugar transport system periplasmic component
HPJ96_RS03320	COG1129	ABC transporter
HPJ96_RS03325	COG4211	Belongs to the binding-protein-dependent transport system permease family
HPJ96_RS03550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPJ96_RS03575	COG0840	transmembrane signaling receptor activity
HPJ96_RS03580	COG2339	peptidase activity
HPJ96_RS03585	COG0151	Belongs to the GarS family
HPJ96_RS03590	COG0138	bifunctional purine biosynthesis protein purh
HPJ96_RS03610	COG1509	lysine 2,3-aminomutase activity
HPJ96_RS03615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPJ96_RS03625	COG1177	transmembrane transport
HPJ96_RS03630	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPJ96_RS03635	COG3842	ATPase activity
HPJ96_RS03640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPJ96_RS03650	COG0724	RNA recognition motif
HPJ96_RS03660	COG1979	alcohol dehydrogenase
HPJ96_RS03670	COG0791	NLP P60 protein
HPJ96_RS03670	COG1388	LysM domain
HPJ96_RS03675	COG0318	PFAM AMP-dependent synthetase and ligase
HPJ96_RS03685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPJ96_RS03685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPJ96_RS03690	COG0739	heme binding
HPJ96_RS03700	COG0295	cytidine deaminase activity
HPJ96_RS03710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPJ96_RS03730	COG1272	protein, Hemolysin III
HPJ96_RS03765	COG2239	Acts as a magnesium transporter
HPJ96_RS03770	COG0460	homoserine dehydrogenase
HPJ96_RS03775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPJ96_RS03780	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HPJ96_RS03795	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HPJ96_RS03805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPJ96_RS03810	COG4608	Belongs to the ABC transporter superfamily
HPJ96_RS03815	COG0444	Belongs to the ABC transporter superfamily
HPJ96_RS03825	COG0601	transmembrane transport
HPJ96_RS03835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPJ96_RS03840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPJ96_RS03840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPJ96_RS03855	COG0523	cobalamin synthesis protein
HPJ96_RS03865	COG1349	DNA-binding transcription factor activity
HPJ96_RS03875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPJ96_RS03880	COG0191	fructose-bisphosphate aldolase activity
HPJ96_RS03885	COG0673	inositol 2-dehydrogenase activity
HPJ96_RS03890	COG1228	amidohydrolase
HPJ96_RS03920	COG0432	Pfam Uncharacterised protein family UPF0047
HPJ96_RS03930	COG0513	Belongs to the DEAD box helicase family
HPJ96_RS03950	COG1131	(ABC) transporter
HPJ96_RS03965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPJ96_RS03975	COG1129	ABC transporter
HPJ96_RS03980	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPJ96_RS03990	COG0617	tRNA 3'-terminal CCA addition
HPJ96_RS03995	COG0668	transmembrane transport
HPJ96_RS04035	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPJ96_RS04045	COG0084	hydrolase, TatD family'
HPJ96_RS04050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPJ96_RS04055	COG3118	belongs to the thioredoxin family
HPJ96_RS04060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPJ96_RS04080	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPJ96_RS04095	COG2357	RelA SpoT domain protein
HPJ96_RS04100	COG0268	Binds directly to 16S ribosomal RNA
HPJ96_RS04105	COG0776	regulation of translation
HPJ96_RS04110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPJ96_RS04120	COG1058	Belongs to the CinA family
HPJ96_RS04120	COG1546	Belongs to the CinA family
HPJ96_RS04125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPJ96_RS04130	COG0254	rRNA binding
HPJ96_RS04160	COG0395	ABC-type sugar transport system, permease component
HPJ96_RS04165	COG1175	transmembrane transport
HPJ96_RS04190	COG0395	ABC-type sugar transport system, permease component
HPJ96_RS04205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPJ96_RS04210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPJ96_RS04210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPJ96_RS04235	COG0488	(ABC) transporter
HPJ96_RS04255	COG0494	nUDIX hydrolase
HPJ96_RS04265	COG0205	6-phosphofructokinase activity
HPJ96_RS04270	COG0629	single-stranded DNA binding
HPJ96_RS04285	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPJ96_RS04295	COG0617	tRNA 3'-terminal CCA addition
HPJ96_RS04300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPJ96_RS04305	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPJ96_RS04305	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPJ96_RS04315	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HPJ96_RS04325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPJ96_RS04340	COG0616	signal peptide processing
HPJ96_RS04345	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPJ96_RS04350	COG0681	Belongs to the peptidase S26 family
HPJ96_RS04370	COG0750	zinc metalloprotease
HPJ96_RS04375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPJ96_RS04380	COG4589	Belongs to the CDS family
HPJ96_RS04385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPJ96_RS04390	COG0233	cytoplasmic translational termination
HPJ96_RS04395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPJ96_RS04400	COG0052	Belongs to the universal ribosomal protein uS2 family
HPJ96_RS04415	COG1136	(ABC) transporter
HPJ96_RS04425	COG0577	efflux transmembrane transporter activity
HPJ96_RS04430	COG0513	Belongs to the DEAD box helicase family
HPJ96_RS04435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPJ96_RS04445	COG1254	Belongs to the acylphosphatase family
HPJ96_RS04460	COG0187	DNA topoisomerase II activity
HPJ96_RS04550	COG1285	pathogenesis
HPJ96_RS04555	COG3330	Domain of unknown function (DUF4912)
HPJ96_RS04570	COG0455	bacterial-type flagellum organization
HPJ96_RS04580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPJ96_RS04605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPJ96_RS04610	COG0740	serine-type endopeptidase activity
HPJ96_RS04615	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPJ96_RS04660	COG3116	cell division
HPJ96_RS04660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPJ96_RS04665	COG0084	hydrolase, TatD family'
HPJ96_RS04680	COG5377	YqaJ viral recombinase family
HPJ96_RS04700	COG3723	Recombinational DNA repair protein, rece pathway
HPJ96_RS05085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPJ96_RS05095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPJ96_RS05105	COG0360	Binds together with S18 to 16S ribosomal RNA
HPJ96_RS05110	COG0629	single-stranded DNA binding
HPJ96_RS05115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPJ96_RS05120	COG0359	binds to the 23S rRNA
HPJ96_RS05125	COG0305	Participates in initiation and elongation during chromosome replication
HPJ96_RS05160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPJ96_RS05165	COG1160	GTP binding
HPJ96_RS05195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPJ96_RS05195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPJ96_RS05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPJ96_RS05220	COG0484	heat shock protein binding
HPJ96_RS05225	COG0443	Heat shock 70 kDa protein
HPJ96_RS05230	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPJ96_RS05235	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HPJ96_RS05240	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HPJ96_RS05260	COG1269	ATP hydrolysis coupled proton transport
HPJ96_RS05265	COG1527	subunit (C
HPJ96_RS05275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPJ96_RS05275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPJ96_RS05275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPJ96_RS05280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPJ96_RS05295	COG2313	pseudouridylate synthase activity
HPJ96_RS05300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPJ96_RS05305	COG2001	Belongs to the MraZ family
HPJ96_RS05310	COG0275	rRNA processing
HPJ96_RS05320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPJ96_RS05325	COG0772	Belongs to the SEDS family
HPJ96_RS05330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPJ96_RS05340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPJ96_RS05345	COG4974	Belongs to the 'phage' integrase family
HPJ96_RS05355	COG0758	DNA mediated transformation
HPJ96_RS05360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPJ96_RS05360	COG0551	DNA topoisomerase type I activity
HPJ96_RS05365	COG4974	Belongs to the 'phage' integrase family
HPJ96_RS05370	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPJ96_RS05375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPJ96_RS05380	COG1815	bacterial-type flagellum-dependent cell motility
HPJ96_RS05395	COG1766	The M ring may be actively involved in energy transduction
HPJ96_RS05405	COG1317	bacterial-type flagellum organization
HPJ96_RS05410	COG1157	protein secretion by the type III secretion system
HPJ96_RS05420	COG0019	diaminopimelate decarboxylase activity
HPJ96_RS05430	COG0438	transferase activity, transferring glycosyl groups
HPJ96_RS05455	COG2186	Transcriptional regulator
HPJ96_RS05480	COG0277	FAD linked oxidase domain protein
HPJ96_RS05485	COG1490	D-aminoacyl-tRNA deacylase activity
HPJ96_RS05490	COG0193	aminoacyl-tRNA hydrolase activity
HPJ96_RS05510	COG1473	amidohydrolase
HPJ96_RS05525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPJ96_RS05535	COG0545	Peptidyl-prolyl cis-trans isomerase
HPJ96_RS05555	COG2217	Heavy metal translocating P-type atpase
HPJ96_RS05560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPJ96_RS05565	COG0813	purine-nucleoside phosphorylase activity
HPJ96_RS05570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPJ96_RS05580	COG0840	transmembrane signaling receptor activity
HPJ96_RS05605	COG2003	Belongs to the UPF0758 family
HPJ96_RS05635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPJ96_RS05650	COG0300	oxidoreductase activity
HPJ96_RS05655	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HPJ96_RS05660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPJ96_RS05665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPJ96_RS05670	COG3630	sodium ion export across plasma membrane
HPJ96_RS05675	COG0511	ligase activity, forming carbon-carbon bonds
HPJ96_RS05675	COG5016	pyruvate
HPJ96_RS05685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPJ96_RS05690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPJ96_RS05705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPJ96_RS05710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPJ96_RS05720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPJ96_RS05725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPJ96_RS05730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPJ96_RS05790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPJ96_RS05815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPJ96_RS05830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPJ96_RS05850	COG0542	response to heat
HPJ96_RS05895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPJ96_RS05940	COG1366	Belongs to the anti-sigma-factor antagonist family
HPJ96_RS05950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPJ96_RS05960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPJ96_RS05965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPJ96_RS05995	COG1640	4-alpha-glucanotransferase
HPJ96_RS06015	COG1136	(ABC) transporter
HPJ96_RS06020	COG0672	)-iron permease
HPJ96_RS06025	COG3470	protein probably involved in high-affinity Fe2 transport
HPJ96_RS06040	COG1136	(ABC) transporter
HPJ96_RS06040	COG0577	efflux transmembrane transporter activity
HPJ96_RS06055	COG1136	(ABC) transporter
HPJ96_RS06070	COG3976	FMN-binding domain protein
HPJ96_RS06070	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HPJ96_RS06075	COG2070	2-Nitropropane dioxygenase
HPJ96_RS06080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPJ96_RS06095	COG0739	heme binding
HPJ96_RS06110	COG0666	response to abiotic stimulus
HPJ96_RS06145	COG2502	aspartate--ammonia ligase
HPJ96_RS06155	COG1704	LemA family
HPJ96_RS06165	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HPJ96_RS06195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPJ96_RS06200	COG0301	tRNA thio-modification
HPJ96_RS06215	COG4786	Flagellar basal body rod
HPJ96_RS06220	COG2188	Transcriptional regulator
HPJ96_RS06225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPJ96_RS06225	COG2190	(PTS) system
HPJ96_RS06225	COG1263	PTS System
HPJ96_RS06230	COG0561	phosphatase activity
HPJ96_RS06235	COG2723	6-phospho-beta-galactosidase activity
HPJ96_RS06260	COG0840	transmembrane signaling receptor activity
HPJ96_RS06265	COG1516	flagellar protein fliS
HPJ96_RS06275	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPJ96_RS06280	COG3118	belongs to the thioredoxin family
HPJ96_RS06290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPJ96_RS06290	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HPJ96_RS06295	COG5002	protein histidine kinase activity
HPJ96_RS06295	COG5001	Diguanylate cyclase
HPJ96_RS06320	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPJ96_RS06335	COG4946	Tricorn protease homolog
HPJ96_RS06335	COG0823	Involved in the tonB-independent uptake of proteins
HPJ96_RS06335	COG1506	peptidase
HPJ96_RS06340	COG0840	transmembrane signaling receptor activity
HPJ96_RS06345	COG5002	protein histidine kinase activity
HPJ96_RS06355	COG0704	Plays a role in the regulation of phosphate uptake
HPJ96_RS06360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPJ96_RS06365	COG0581	inorganic phosphate transmembrane transporter activity
HPJ96_RS06370	COG0573	inorganic phosphate transmembrane transporter activity
HPJ96_RS06375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPJ96_RS06405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPJ96_RS06440	COG3052	prosthetic group binding
HPJ96_RS06470	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HPJ96_RS06490	COG1129	ABC transporter
HPJ96_RS06510	COG2226	methyltransferase
HPJ96_RS06545	COG3177	Filamentation induced by cAMP protein fic
HPJ96_RS06745	COG2226	methyltransferase
HPJ96_RS06770	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPJ96_RS06775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPJ96_RS06780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPJ96_RS06780	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPJ96_RS06785	COG0739	heme binding
HPJ96_RS06790	COG1132	(ABC) transporter
HPJ96_RS06795	COG1132	(ABC) transporter
HPJ96_RS06800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPJ96_RS06815	COG2801	Transposase and inactivated derivatives
HPJ96_RS06830	COG1187	pseudouridine synthase activity
HPJ96_RS06855	COG1132	(ABC) transporter
HPJ96_RS06860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPJ96_RS06880	COG3706	GGDEF domain
HPJ96_RS06895	COG1413	lyase activity
HPJ96_RS06905	COG1012	belongs to the aldehyde dehydrogenase family
HPJ96_RS06915	COG0673	inositol 2-dehydrogenase activity
HPJ96_RS06920	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPJ96_RS06930	COG1879	ABC-type sugar transport system periplasmic component
HPJ96_RS06955	COG2610	gluconate transmembrane transporter activity
HPJ96_RS06960	COG1929	Belongs to the glycerate kinase type-1 family
HPJ96_RS06970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPJ96_RS06975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPJ96_RS06990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPJ96_RS07045	COG0110	maltose O-acetyltransferase activity
HPJ96_RS07055	COG3579	cysteine-type endopeptidase activity
HPJ96_RS07070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPJ96_RS07085	COG3437	response regulator, receiver
HPJ96_RS07085	COG2770	Histidine kinase
HPJ96_RS07090	COG1214	PFAM Peptidase M22, glycoprotease
HPJ96_RS07095	COG0802	atpase or kinase
HPJ96_RS07100	COG0322	excinuclease ABC activity
HPJ96_RS07125	COG2885	chlorophyll binding
HPJ96_RS07135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPJ96_RS07140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPJ96_RS07150	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPJ96_RS07150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPJ96_RS07175	COG0564	pseudouridine synthase activity
HPJ96_RS07185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPJ96_RS07200	COG1573	uracil-dna glycosylase
HPJ96_RS07205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPJ96_RS07210	COG1086	Polysaccharide biosynthesis protein
HPJ96_RS07215	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HPJ96_RS07230	COG1136	(ABC) transporter
HPJ96_RS07245	COG0552	protein localization to endoplasmic reticulum
HPJ96_RS07275	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPJ96_RS07280	COG3457	Alanine racemase
HPJ96_RS07285	COG0626	cystathionine gamma-synthase activity
HPJ96_RS07320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPJ96_RS07340	COG1473	amidohydrolase
HPJ96_RS07350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPJ96_RS07355	COG1121	(ABC) transporter
HPJ96_RS07360	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPJ96_RS07370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPJ96_RS07375	COG2604	Protein of unknown function DUF115
HPJ96_RS07385	COG1592	Rubrerythrin
HPJ96_RS07405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPJ96_RS07405	COG0574	Belongs to the PEP-utilizing enzyme family
HPJ96_RS07410	COG1760	l-serine dehydratase
HPJ96_RS07415	COG1760	l-serine dehydratase
HPJ96_RS07420	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HPJ96_RS07440	COG2604	Protein of unknown function DUF115
HPJ96_RS07445	COG0768	penicillin binding
HPJ96_RS07455	COG1227	inorganic diphosphatase activity
HPJ96_RS07455	COG0517	IMP dehydrogenase activity
HPJ96_RS07470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPJ96_RS07475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPJ96_RS07480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPJ96_RS07505	COG0739	heme binding
HPJ96_RS07520	COG5377	YqaJ viral recombinase family
HPJ96_RS07540	COG3723	Recombinational DNA repair protein, rece pathway
HPJ96_RS07865	COG0739	heme binding
HPJ96_RS07875	COG0351	phosphomethylpyrimidine kinase
HPJ96_RS07880	COG0495	leucyl-tRNA aminoacylation
HPJ96_RS07890	COG2089	acid synthase
HPJ96_RS07905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPJ96_RS07910	COG2373	Large extracellular alpha-helical protein
HPJ96_RS07915	COG4953	penicillin-binding protein 1C
HPJ96_RS07920	COG1192	Involved in chromosome partitioning
HPJ96_RS07925	COG1475	DNA binding
HPJ96_RS07935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPJ96_RS07945	COG1388	LysM domain
HPJ96_RS07945	COG0741	lytic transglycosylase activity
HPJ96_RS07960	COG1040	competence protein
HPJ96_RS07965	COG4209	transmembrane transport
HPJ96_RS07995	COG2197	response regulator
HPJ96_RS08010	COG0493	'glutamate synthase
HPJ96_RS08015	COG0543	2 iron, 2 sulfur cluster binding
HPJ96_RS08020	COG0740	serine-type endopeptidase activity
HPJ96_RS08035	COG0531	amino acid
HPJ96_RS08070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPJ96_RS08110	COG0563	adenylate kinase activity
HPJ96_RS08120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPJ96_RS08125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPJ96_RS08130	COG0571	ribonuclease III activity
HPJ96_RS08140	COG3700	Belongs to the class B bacterial acid phosphatase family
HPJ96_RS08150	COG1187	pseudouridine synthase activity
HPJ96_RS08155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HPJ96_RS08160	COG3735	TraB family
HPJ96_RS08165	COG0180	Tryptophanyl-tRNA synthetase
HPJ96_RS08175	COG1131	(ABC) transporter
HPJ96_RS08185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPJ96_RS08185	COG0574	Belongs to the PEP-utilizing enzyme family
HPJ96_RS08200	COG2304	oxidoreductase activity
HPJ96_RS08205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPJ96_RS08205	COG0426	domain, Protein
HPJ96_RS08210	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HPJ96_RS08220	COG1394	ATPase activity, coupled to movement of substances
HPJ96_RS08230	COG0085	RNA polymerase activity
HPJ96_RS08245	COG0081	regulation of translation
HPJ96_RS08250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPJ96_RS08255	COG0250	Participates in transcription elongation, termination and antitermination
HPJ96_RS08260	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPJ96_RS08270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPJ96_RS08280	COG0716	FMN binding
HPJ96_RS08295	COG2610	gluconate transmembrane transporter activity
HPJ96_RS08305	COG2030	dehydratase
HPJ96_RS08515	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HPJ96_RS08585	COG2932	Transcriptional regulator
HPJ96_RS08600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPJ96_RS08615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPJ96_RS08620	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HPJ96_RS08625	COG3328	transposase activity
HPJ96_RS08635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPJ96_RS08640	COG1640	4-alpha-glucanotransferase
HPJ96_RS08650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPJ96_RS08660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPJ96_RS08665	COG0706	membrane insertase activity
HPJ96_RS08680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPJ96_RS08685	COG1305	Transglutaminase-like
HPJ96_RS08695	COG0714	Associated with various cellular activities
HPJ96_RS08700	COG0363	glucosamine-6-phosphate deaminase activity
HPJ96_RS08710	COG3842	ATPase activity
HPJ96_RS08715	COG1178	ABC-type Fe3 transport system permease component
HPJ96_RS08730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPJ96_RS08745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPJ96_RS08780	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HPJ96_RS08780	COG0028	Belongs to the TPP enzyme family
HPJ96_RS08790	COG0673	inositol 2-dehydrogenase activity
HPJ96_RS08830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPJ96_RS08875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPJ96_RS08910	COG0251	oxidation-reduction process
HPJ96_RS08915	COG1438	arginine binding
HPJ96_RS08920	COG1475	DNA binding
HPJ96_RS08925	COG0457	Tetratricopeptide repeat
HPJ96_RS08935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPJ96_RS08940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HPJ96_RS08965	COG0542	response to heat
HPJ96_RS08970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPJ96_RS08980	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPJ96_RS08985	COG0584	glycerophosphoryl diester phosphodiesterase
HPJ96_RS08990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPJ96_RS08995	COG0762	integral membrane protein
HPJ96_RS09000	COG0587	DNA-directed DNA polymerase activity
HPJ96_RS09005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPJ96_RS09020	COG0405	Gamma-glutamyltransferase
HPJ96_RS09045	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPJ96_RS09060	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HPJ96_RS09070	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HPJ96_RS09075	COG2204	response regulator
HPJ96_RS09095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HPJ96_RS09095	COG0321	lipoyl(octanoyl) transferase activity
HPJ96_RS09115	COG0530	calcium, potassium:sodium antiporter activity
HPJ96_RS09135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPJ96_RS09150	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HPJ96_RS09160	COG1115	amino acid carrier protein
HPJ96_RS09180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPJ96_RS09190	COG1692	metallophosphoesterase
HPJ96_RS09195	COG1879	ABC-type sugar transport system periplasmic component
HPJ96_RS09200	COG0037	tRNA processing
HPJ96_RS09205	COG1309	transcriptional regulator
HPJ96_RS09215	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPJ96_RS09225	COG1047	Peptidyl-prolyl cis-trans
HPJ96_RS09235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPJ96_RS09240	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPJ96_RS09250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPJ96_RS09265	COG1193	negative regulation of DNA recombination
HPJ96_RS09270	COG1162	GTPase activity
HPJ96_RS09285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPJ96_RS09310	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPJ96_RS09310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPJ96_RS09310	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPJ96_RS09310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPJ96_RS09325	COG1918	ferrous iron import across plasma membrane
HPJ96_RS09325	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPJ96_RS09375	COG2204	response regulator
HPJ96_RS09380	COG3852	Histidine kinase
HPJ96_RS09385	COG0470	DNA polymerase III
HPJ96_RS09390	COG1286	toxin biosynthetic process
HPJ96_RS09395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPJ96_RS09415	COG1692	metallophosphoesterase
HPJ96_RS09425	COG0142	geranyltranstransferase activity
HPJ96_RS09440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPJ96_RS09445	COG0205	6-phosphofructokinase activity
HPJ96_RS09450	COG2801	Transposase and inactivated derivatives
HPJ96_RS09475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPJ96_RS09480	COG2801	Transposase and inactivated derivatives
HPJ96_RS09485	COG2801	Transposase and inactivated derivatives
HPJ96_RS09495	COG0017	Asparaginyl-tRNA synthetase
HPJ96_RS09500	COG0840	transmembrane signaling receptor activity
HPJ96_RS09520	COG0326	Molecular chaperone. Has ATPase activity
HPJ96_RS09525	COG0517	IMP dehydrogenase activity
HPJ96_RS09555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPJ96_RS09570	COG0840	transmembrane signaling receptor activity
HPJ96_RS09580	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPJ96_RS09600	COG2604	Protein of unknown function DUF115
HPJ96_RS09625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPJ96_RS09630	COG1418	mRNA catabolic process
HPJ96_RS09645	COG1686	Belongs to the peptidase S11 family
HPJ96_RS09655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPJ96_RS09700	COG0514	ATP-dependent DNA helicase (RecQ)
HPJ96_RS09705	COG0395	ABC-type sugar transport system, permease component
HPJ96_RS09710	COG1175	transmembrane transport
HPJ96_RS09740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPJ96_RS09745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPJ96_RS09745	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPJ96_RS09755	COG3037	sugar-specific permease SgaT UlaA
HPJ96_RS09770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPJ96_RS09780	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPJ96_RS09785	COG2911	Protein conserved in bacteria
HPJ96_RS09790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPJ96_RS09800	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPJ96_RS09805	COG0534	Mate efflux family protein
HPJ96_RS09825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPJ96_RS09835	COG4608	Belongs to the ABC transporter superfamily
HPJ96_RS09840	COG0444	Belongs to the ABC transporter superfamily
HPJ96_RS09845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPJ96_RS09850	COG0601	transmembrane transport
HPJ96_RS09860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPJ96_RS09865	COG0671	phosphoesterase, PA-phosphatase related
HPJ96_RS09880	COG0497	DNA recombination
HPJ96_RS09885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPJ96_RS09890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPJ96_RS09895	COG0835	chemotaxis
HPJ96_RS09940	COG3876	Protein conserved in bacteria
HPJ96_RS09945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPJ96_RS09950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPJ96_RS09955	COG0569	domain protein
HPJ96_RS09970	COG0714	Associated with various cellular activities
HPJ96_RS09985	COG1366	Belongs to the anti-sigma-factor antagonist family
HPJ96_RS10005	COG0653	protein targeting
HPJ96_RS10010	COG1132	(ABC) transporter
HPJ96_RS10015	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPJ96_RS10020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPJ96_RS10025	COG0626	cystathionine gamma-synthase activity
HPJ96_RS10030	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPJ96_RS10030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPJ96_RS10030	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPJ96_RS10030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPJ96_RS10035	COG2986	histidine ammonia-lyase
HPJ96_RS10040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPJ96_RS10045	COG4209	transmembrane transport
HPJ96_RS10050	COG0395	ABC-type sugar transport system, permease component
HPJ96_RS10060	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HPJ96_RS10065	COG1609	Transcriptional regulator
HPJ96_RS10080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPJ96_RS10090	COG3681	Belongs to the UPF0597 family
HPJ96_RS10100	COG0561	phosphatase activity
HPJ96_RS10110	COG0733	neurotransmitter:sodium symporter activity
HPJ96_RS10115	COG0210	DNA helicase
HPJ96_RS10165	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPJ96_RS10175	COG0335	large ribosomal subunit rRNA binding
HPJ96_RS10180	COG0336	Belongs to the RNA methyltransferase TrmD family
HPJ96_RS10185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPJ96_RS10190	COG1837	Belongs to the UPF0109 family
HPJ96_RS10195	COG0228	four-way junction DNA binding
HPJ96_RS10220	COG0516	GMP reductase activity
HPJ96_RS10220	COG0517	IMP dehydrogenase activity
HPJ96_RS10225	COG1309	transcriptional regulator
HPJ96_RS10235	COG1132	(ABC) transporter
HPJ96_RS10250	COG2081	HI0933 family
HPJ96_RS10255	COG1053	succinate dehydrogenase
HPJ96_RS10260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPJ96_RS10265	COG0049	tRNA binding
HPJ96_RS10320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPJ96_RS10340	COG1744	ABC transporter substrate-binding protein PnrA-like
HPJ96_RS10375	COG0778	Nitroreductase
HPJ96_RS10385	COG0840	transmembrane signaling receptor activity
HPJ96_RS10420	COG0433	COG0433 Predicted ATPase
HPJ96_RS10455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPJ96_RS10460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPJ96_RS10485	COG0126	phosphoglycerate kinase activity
HPJ96_RS10490	COG0149	triose-phosphate isomerase activity
HPJ96_RS10505	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPJ96_RS10510	COG0588	phosphoglycerate mutase activity
HPJ96_RS10530	COG0789	Transcriptional regulator
HPJ96_RS10545	COG1979	alcohol dehydrogenase
HPJ96_RS10555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPJ96_RS10560	COG0786	glutamate:sodium symporter activity
HPJ96_RS10630	COG2197	response regulator
HPJ96_RS10635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPJ96_RS10655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPJ96_RS10665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPJ96_RS10690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPJ96_RS10705	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPJ96_RS10710	COG2088	sporulation resulting in formation of a cellular spore
HPJ96_RS10720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HPJ96_RS10725	COG0037	tRNA processing
HPJ96_RS10730	COG0457	Tetratricopeptide repeat
HPJ96_RS10735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPJ96_RS10740	COG0481	GTPase activity
HPJ96_RS10770	COG2885	chlorophyll binding
HPJ96_RS10830	COG0629	single-stranded DNA binding
HPJ96_RS11095	COG0167	dihydroorotate dehydrogenase activity
HPJ96_RS11110	COG1199	ATP-dependent helicase activity
HPJ96_RS11115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPJ96_RS11120	COG0006	proline dipeptidase activity
HPJ96_RS11130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPJ96_RS11170	COG0484	heat shock protein binding
HPJ96_RS11175	COG0024	Methionine aminopeptidase
HPJ96_RS11185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPJ96_RS11200	COG3064	Membrane
HPJ96_RS11205	COG2211	Major facilitator Superfamily
HPJ96_RS11210	COG1598	PFAM Uncharacterised protein family UPF0150
HPJ96_RS11220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPJ96_RS11225	COG2878	Part of a membrane complex involved in electron transport
HPJ96_RS11225	COG1245	4Fe-4S binding domain
HPJ96_RS11230	COG4657	Part of a membrane complex involved in electron transport
HPJ96_RS11235	COG4660	Part of a membrane complex involved in electron transport
HPJ96_RS11245	COG4658	electron transport chain
HPJ96_RS11250	COG4656	Part of a membrane complex involved in electron transport
HPJ96_RS11270	COG1234	tRNA 3'-trailer cleavage
HPJ96_RS11280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPJ96_RS11285	COG0358	DNA primase activity
HPJ96_RS11290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPJ96_RS11310	COG1077	Cell shape determining protein MreB Mrl
HPJ96_RS11325	COG0768	penicillin binding
HPJ96_RS11330	COG0772	Belongs to the SEDS family
HPJ96_RS11335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPJ96_RS11345	COG1104	cysteine desulfurase activity
HPJ96_RS11360	COG0709	Synthesizes selenophosphate from selenide and ATP
HPJ96_RS11365	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPJ96_RS11365	COG3608	succinylglutamate desuccinylase aspartoacylase
HPJ96_RS11370	COG0746	molybdenum cofactor guanylyltransferase activity
HPJ96_RS11380	COG3842	ATPase activity
HPJ96_RS11385	COG4149	molybdate abc transporter
HPJ96_RS11390	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPJ96_RS11400	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPJ96_RS11415	COG0315	cyclic pyranopterin monophosphate synthase activity
HPJ96_RS11420	COG1546	Belongs to the CinA family
HPJ96_RS11420	COG1058	Belongs to the CinA family
HPJ96_RS11425	COG3608	succinylglutamate desuccinylase aspartoacylase
HPJ96_RS11425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPJ96_RS11430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPJ96_RS11440	COG0402	S-adenosylhomocysteine deaminase activity
HPJ96_RS11445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPJ96_RS11445	COG0493	'glutamate synthase
HPJ96_RS11455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPJ96_RS11460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPJ96_RS11480	COG3404	Formiminotransferase-cyclodeaminase
HPJ96_RS11495	COG2986	histidine ammonia-lyase
HPJ96_RS11500	COG2056	Na+-H+ antiporter family
HPJ96_RS11510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPJ96_RS11515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPJ96_RS11520	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPJ96_RS11540	COG0101	tRNA pseudouridine synthase activity
HPJ96_RS11545	COG0297	glycogen (starch) synthase activity
HPJ96_RS11555	COG0427	acetyl-CoA hydrolase
HPJ96_RS11560	COG1024	Enoyl-CoA hydratase
HPJ96_RS11565	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPJ96_RS11570	COG0426	domain, Protein
HPJ96_RS11575	COG1960	acyl-CoA dehydrogenase activity
HPJ96_RS11580	COG0183	Belongs to the thiolase family
HPJ96_RS11590	COG1263	PTS System
HPJ96_RS11590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPJ96_RS11595	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPJ96_RS11600	COG0708	Exodeoxyribonuclease III
HPJ96_RS11610	COG4443	Transcriptional Coactivator p15 (PC4)
HPJ96_RS11615	COG0328	RNA-DNA hybrid ribonuclease activity
HPJ96_RS11620	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPJ96_RS11625	COG4988	ABC transporter
HPJ96_RS11630	COG1294	oxidase, subunit
HPJ96_RS11635	COG1271	oxidase subunit
HPJ96_RS11700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPJ96_RS11705	COG0728	peptidoglycan biosynthetic process
HPJ96_RS11720	COG0579	oxidoreductase
HPJ96_RS11725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HPJ96_RS11730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPJ96_RS11735	COG0124	histidyl-tRNA synthetase
HPJ96_RS11740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPJ96_RS11745	COG0154	amidase activity
HPJ96_RS11755	COG1028	Short-chain dehydrogenase reductase Sdr
HPJ96_RS11760	COG1131	(ABC) transporter
HPJ96_RS11780	COG0701	Predicted permease
HPJ96_RS11790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPJ96_RS11820	COG1137	ATPase activity
HPJ96_RS11825	COG1132	(ABC) transporter
HPJ96_RS11830	COG4988	ABC transporter
HPJ96_RS11840	COG3142	Participates in the control of copper homeostasis
HPJ96_RS11845	COG1335	isochorismatase
HPJ96_RS11915	COG0297	glycogen (starch) synthase activity
HPJ96_RS11965	COG2738	Putative neutral zinc metallopeptidase
HPJ96_RS11995	COG2255	four-way junction helicase activity
HPJ96_RS12000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPJ96_RS12010	COG1362	aminopeptidase activity
HPJ96_RS12020	COG1570	exodeoxyribonuclease VII activity
HPJ96_RS12045	COG4750	Nucleotidyl transferase
HPJ96_RS12050	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPJ96_RS12065	COG0840	transmembrane signaling receptor activity
HPJ96_RS12080	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPJ96_RS12085	COG0456	acetyltransferase
HPJ96_RS12085	COG1214	PFAM Peptidase M22, glycoprotease
HPJ96_RS12090	COG1811	Na channel or pump
HPJ96_RS12105	COG2059	Chromate
HPJ96_RS12125	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPJ96_RS12130	COG1012	belongs to the aldehyde dehydrogenase family
HPJ96_RS12140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPJ96_RS12165	COG1609	Transcriptional regulator
HPJ96_RS12175	COG0632	four-way junction helicase activity
HPJ96_RS12185	COG0457	Tetratricopeptide repeat
HPJ96_RS12190	COG0785	Cytochrome C biogenesis protein
HPJ96_RS12195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPJ96_RS12220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPJ96_RS12225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPJ96_RS12225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPJ96_RS12225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPJ96_RS12230	COG1105	Belongs to the carbohydrate kinase PfkB family
HPJ96_RS12235	COG1349	DNA-binding transcription factor activity
HPJ96_RS12240	COG0450	alkyl hydroperoxide reductase
HPJ96_RS12255	COG1472	Belongs to the glycosyl hydrolase 3 family
HPJ96_RS12260	COG0492	ferredoxin-NADP+ reductase activity
HPJ96_RS12285	COG0444	Belongs to the ABC transporter superfamily
HPJ96_RS12290	COG4608	Belongs to the ABC transporter superfamily
HPJ96_RS12300	COG1132	(ABC) transporter
HPJ96_RS12305	COG1132	(ABC) transporter
HPJ96_RS12310	COG1132	(ABC) transporter
HPJ96_RS12315	COG1132	(ABC) transporter
HPJ96_RS12325	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPJ96_RS12355	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HPJ96_RS12370	COG2801	Transposase and inactivated derivatives
HPJ96_RS12380	COG0584	glycerophosphoryl diester phosphodiesterase
HPJ96_RS12385	COG3958	Transketolase
HPJ96_RS12390	COG3959	Transketolase, thiamine diphosphate binding domain
HPJ96_RS12410	COG1122	ATPase activity
HPJ96_RS12415	COG1268	BioY protein
HPJ96_RS12420	COG0012	GTP binding
HPJ96_RS12425	COG0205	6-phosphofructokinase activity
HPJ96_RS12455	COG1477	protein flavinylation
HPJ96_RS12510	COG5433	transposase activity
HPJ96_RS12640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPJ96_RS12740	COG0519	Catalyzes the synthesis of GMP from XMP
HPJ96_RS12830	COG2376	Dihydroxyacetone kinase
HPJ96_RS12845	COG0557	exoribonuclease II activity
HPJ96_RS12865	COG1129	ABC transporter
HPJ96_RS12885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPJ96_RS12905	COG1234	tRNA 3'-trailer cleavage
HPJ96_RS12910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPJ96_RS12945	COG3885	ferrous iron binding
HPJ96_RS12945	COG2078	PFAM AMMECR1 domain protein
HPJ96_RS12950	COG1022	Amp-dependent synthetase and ligase
HPJ96_RS12955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HPJ96_RS12960	COG1486	melibiose metabolic process
HPJ96_RS12970	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
HPJ96_RS12975	COG2982	Protein involved in outer membrane biogenesis
HPJ96_RS12980	COG0697	spore germination
HPJ96_RS12990	COG0217	transcriptional regulatory protein
HPJ96_RS13000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPJ96_RS13005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPJ96_RS13010	COG0840	transmembrane signaling receptor activity
HPJ96_RS13025	COG3842	ATPase activity
HPJ96_RS13030	COG1178	ABC-type Fe3 transport system permease component
HPJ96_RS13035	COG3842	ATPase activity
HPJ96_RS13045	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPJ96_RS13070	COG0656	L-ascorbic acid biosynthetic process
HPJ96_RS13110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPJ96_RS13145	COG1151	hydroxylamine reductase activity
HPJ96_RS13175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPJ96_RS13175	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPJ96_RS13175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPJ96_RS13185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPJ96_RS13190	COG0058	SHG alpha-glucan phosphorylase activity
HPJ96_RS13195	COG0235	Class ii aldolase
HPJ96_RS13200	COG1063	alcohol dehydrogenase
HPJ96_RS13205	COG1349	DNA-binding transcription factor activity
HPJ96_RS13210	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPJ96_RS13210	COG2213	PTS system mannitol-specific
HPJ96_RS13215	COG1690	Belongs to the RtcB family
HPJ96_RS13220	COG1164	Oligoendopeptidase f
HPJ96_RS13235	COG0840	transmembrane signaling receptor activity
HPJ96_RS13245	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HPJ96_RS13265	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPJ96_RS13285	COG1360	Flagellar Motor Protein
HPJ96_RS13290	COG1580	Controls the rotational direction of flagella during chemotaxis
HPJ96_RS13295	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPJ96_RS13300	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPJ96_RS13300	COG1776	CheC inhibitor of MCP methylation
HPJ96_RS13310	COG1338	Plays a role in the flagellum-specific transport system
HPJ96_RS13315	COG1987	bacterial-type flagellum assembly
HPJ96_RS13320	COG1684	flagellar biosynthetic protein fliR
HPJ96_RS13325	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPJ96_RS13330	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPJ96_RS13335	COG1419	protein localization to endoplasmic reticulum
HPJ96_RS13345	COG3437	response regulator, receiver
HPJ96_RS13350	COG1671	Belongs to the UPF0178 family
HPJ96_RS13360	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HPJ96_RS13370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPJ96_RS13385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPJ96_RS13390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPJ96_RS13405	COG0237	dephospho-CoA kinase activity
HPJ96_RS13410	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPJ96_RS13415	COG0710	3-dehydroquinate dehydratase activity
HPJ96_RS13415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPJ96_RS13430	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPJ96_RS13440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPJ96_RS13445	COG0739	heme binding
HPJ96_RS13460	COG1774	PSP1 C-terminal conserved region
HPJ96_RS13490	COG1078	dGTPase activity
HPJ96_RS13495	COG2033	superoxide reductase activity
HPJ96_RS13500	COG1652	LysM domain
HPJ96_RS13500	COG2823	Periplasmic or secreted lipoprotein
HPJ96_RS13510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPJ96_RS13515	COG0051	transcription antitermination factor activity, RNA binding
HPJ96_RS13520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPJ96_RS13525	COG0088	Forms part of the polypeptide exit tunnel
HPJ96_RS13530	COG0089	rRNA binding
HPJ96_RS13535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPJ96_RS13545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPJ96_RS13550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPJ96_RS13560	COG0255	Belongs to the universal ribosomal protein uL29 family
HPJ96_RS13565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPJ96_RS13580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPJ96_RS13590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPJ96_RS13595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPJ96_RS13600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPJ96_RS13610	COG1841	ribosomal large subunit assembly
HPJ96_RS13615	COG0200	Binds to the 23S rRNA
HPJ96_RS13625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPJ96_RS13635	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPJ96_RS13640	COG0202	RNA polymerase activity
HPJ96_RS13645	COG0203	ribosomal protein L17
HPJ96_RS13670	COG0848	biopolymer transport protein
HPJ96_RS13675	COG0811	peptide transport
HPJ96_RS13680	COG0515	serine threonine protein kinase
HPJ96_RS13680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPJ96_RS13700	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPJ96_RS13705	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPJ96_RS13735	COG0719	Fe-S assembly protein
HPJ96_RS13740	COG0719	Fe-S assembly protein
HPJ96_RS13745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPJ96_RS13750	COG0822	iron-sulfur transferase activity
HPJ96_RS13770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPJ96_RS13780	COG0670	Belongs to the BI1 family
HPJ96_RS13790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPJ96_RS13800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPJ96_RS13810	COG1129	ABC transporter
HPJ96_RS13815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPJ96_RS13825	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPJ96_RS13850	COG0116	Belongs to the methyltransferase superfamily
HPJ96_RS13855	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPJ96_RS13860	COG1687	branched-chain amino acid