locus-tag	class	description
DWQ65_RS00020	COG0826	peptidase U32
DWQ65_RS00025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DWQ65_RS00030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DWQ65_RS00055	COG0126	phosphoglycerate kinase activity
DWQ65_RS00060	COG0149	triose-phosphate isomerase activity
DWQ65_RS00080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DWQ65_RS00085	COG0588	phosphoglycerate mutase activity
DWQ65_RS00105	COG0789	Transcriptional regulator
DWQ65_RS00120	COG1979	alcohol dehydrogenase
DWQ65_RS00130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DWQ65_RS00135	COG0786	glutamate:sodium symporter activity
DWQ65_RS00155	COG2197	response regulator
DWQ65_RS00160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DWQ65_RS00180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DWQ65_RS00190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DWQ65_RS00205	COG0543	2 iron, 2 sulfur cluster binding
DWQ65_RS00210	COG0167	dihydroorotate dehydrogenase activity
DWQ65_RS00225	COG1199	ATP-dependent helicase activity
DWQ65_RS00230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DWQ65_RS00235	COG2211	Major facilitator Superfamily
DWQ65_RS00240	COG3064	Membrane
DWQ65_RS00255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DWQ65_RS00265	COG0840	transmembrane signaling receptor activity
DWQ65_RS00275	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DWQ65_RS00290	COG0024	Methionine aminopeptidase
DWQ65_RS00295	COG0484	heat shock protein binding
DWQ65_RS00335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWQ65_RS00345	COG0006	proline dipeptidase activity
DWQ65_RS00350	COG1598	PFAM Uncharacterised protein family UPF0150
DWQ65_RS00360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DWQ65_RS00365	COG2878	Part of a membrane complex involved in electron transport
DWQ65_RS00365	COG1245	4Fe-4S binding domain
DWQ65_RS00370	COG4657	Part of a membrane complex involved in electron transport
DWQ65_RS00375	COG4660	Part of a membrane complex involved in electron transport
DWQ65_RS00385	COG4658	electron transport chain
DWQ65_RS00390	COG4656	Part of a membrane complex involved in electron transport
DWQ65_RS00410	COG1234	tRNA 3'-trailer cleavage
DWQ65_RS00420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DWQ65_RS00425	COG0358	DNA primase activity
DWQ65_RS00430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWQ65_RS00450	COG1077	Cell shape determining protein MreB Mrl
DWQ65_RS00465	COG0768	penicillin binding
DWQ65_RS00470	COG0772	Belongs to the SEDS family
DWQ65_RS00475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWQ65_RS00485	COG1104	cysteine desulfurase activity
DWQ65_RS00500	COG0709	Synthesizes selenophosphate from selenide and ATP
DWQ65_RS00505	COG3608	succinylglutamate desuccinylase aspartoacylase
DWQ65_RS00505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DWQ65_RS00510	COG0746	molybdenum cofactor guanylyltransferase activity
DWQ65_RS00515	COG3842	ATPase activity
DWQ65_RS00520	COG4149	molybdate abc transporter
DWQ65_RS00525	COG0725	ABC transporter, periplasmic molybdate-binding protein
DWQ65_RS00535	COG0521	Mo-molybdopterin cofactor biosynthetic process
DWQ65_RS00550	COG0315	cyclic pyranopterin monophosphate synthase activity
DWQ65_RS00555	COG1546	Belongs to the CinA family
DWQ65_RS00555	COG1058	Belongs to the CinA family
DWQ65_RS00560	COG3608	succinylglutamate desuccinylase aspartoacylase
DWQ65_RS00560	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DWQ65_RS00565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DWQ65_RS00575	COG0402	S-adenosylhomocysteine deaminase activity
DWQ65_RS00580	COG0493	'glutamate synthase
DWQ65_RS00580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DWQ65_RS00590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWQ65_RS00595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DWQ65_RS00615	COG3404	Formiminotransferase-cyclodeaminase
DWQ65_RS00630	COG2986	histidine ammonia-lyase
DWQ65_RS00635	COG2056	Na+-H+ antiporter family
DWQ65_RS00640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DWQ65_RS00645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DWQ65_RS00650	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DWQ65_RS00670	COG0101	tRNA pseudouridine synthase activity
DWQ65_RS00675	COG0297	glycogen (starch) synthase activity
DWQ65_RS00685	COG0427	acetyl-CoA hydrolase
DWQ65_RS00690	COG1024	Enoyl-CoA hydratase
DWQ65_RS00695	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWQ65_RS00705	COG1960	acyl-CoA dehydrogenase activity
DWQ65_RS00710	COG0183	Belongs to the thiolase family
DWQ65_RS00730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWQ65_RS00735	COG2890	protein-(glutamine-N5) methyltransferase activity
DWQ65_RS00740	COG1022	Amp-dependent synthetase and ligase
DWQ65_RS00745	COG1321	iron dependent repressor
DWQ65_RS00750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWQ65_RS00755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWQ65_RS00760	COG1121	(ABC) transporter
DWQ65_RS00765	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWQ65_RS00770	COG1028	Short-chain dehydrogenase reductase Sdr
DWQ65_RS00780	COG0154	amidase activity
DWQ65_RS00785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWQ65_RS00790	COG0124	histidyl-tRNA synthetase
DWQ65_RS00795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWQ65_RS00800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DWQ65_RS00805	COG0579	oxidoreductase
DWQ65_RS00820	COG0728	peptidoglycan biosynthetic process
DWQ65_RS00825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWQ65_RS00895	COG1271	oxidase subunit
DWQ65_RS00900	COG1294	oxidase, subunit
DWQ65_RS00905	COG4988	ABC transporter
DWQ65_RS00910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DWQ65_RS00915	COG0328	RNA-DNA hybrid ribonuclease activity
DWQ65_RS00920	COG4443	Transcriptional Coactivator p15 (PC4)
DWQ65_RS00930	COG0708	Exodeoxyribonuclease III
DWQ65_RS00935	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DWQ65_RS00955	COG0658	competence protein
DWQ65_RS00955	COG2333	competence protein COMEC
DWQ65_RS00980	COG0285	dihydrofolate synthase activity
DWQ65_RS00985	COG2832	Protein of unknown function (DUF454)
DWQ65_RS00990	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DWQ65_RS01000	COG1269	ATP hydrolysis coupled proton transport
DWQ65_RS01005	COG1394	ATPase activity, coupled to movement of substances
DWQ65_RS01010	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
DWQ65_RS01015	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DWQ65_RS01025	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
DWQ65_RS01055	COG1983	PspC domain protein
DWQ65_RS01090	COG1136	(ABC) transporter
DWQ65_RS01100	COG0577	efflux transmembrane transporter activity
DWQ65_RS01100	COG1136	(ABC) transporter
DWQ65_RS01115	COG4475	Protein of unknown function (DUF436)
DWQ65_RS01120	COG4475	Protein of unknown function (DUF436)
DWQ65_RS01125	COG2252	PERMEase
DWQ65_RS01145	COG0395	ABC-type sugar transport system, permease component
DWQ65_RS01155	COG4209	transmembrane transport
DWQ65_RS01165	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DWQ65_RS01170	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DWQ65_RS01180	COG0786	glutamate:sodium symporter activity
DWQ65_RS01185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWQ65_RS01190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DWQ65_RS01195	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DWQ65_RS01200	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DWQ65_RS01205	COG4770	biotin carboxylase activity
DWQ65_RS01215	COG0786	glutamate:sodium symporter activity
DWQ65_RS01220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWQ65_RS01235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DWQ65_RS01250	COG1744	ABC transporter substrate-binding protein PnrA-like
DWQ65_RS01255	COG3845	ABC transporter
DWQ65_RS01260	COG4603	Belongs to the binding-protein-dependent transport system permease family
DWQ65_RS01265	COG1079	Belongs to the binding-protein-dependent transport system permease family
DWQ65_RS01285	COG1346	cytolysis
DWQ65_RS01305	COG0191	fructose-bisphosphate aldolase activity
DWQ65_RS01330	COG4166	transmembrane transport
DWQ65_RS01345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWQ65_RS01365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWQ65_RS01370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWQ65_RS01375	COG1862	Preprotein translocase
DWQ65_RS01380	COG1639	'signal transduction protein
DWQ65_RS01390	COG4115	mRNA cleavage
DWQ65_RS01405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWQ65_RS01415	COG0504	CTP synthase activity
DWQ65_RS01420	COG1757	Na H antiporter
DWQ65_RS01435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DWQ65_RS01445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWQ65_RS01450	COG0765	amino acid transport
DWQ65_RS01455	COG1126	abc transporter atp-binding protein
DWQ65_RS01470	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DWQ65_RS01480	COG1175	transmembrane transport
DWQ65_RS01490	COG0330	HflC and HflK could
DWQ65_RS01495	COG0330	HflC and HflK could
DWQ65_RS01510	COG1785	Belongs to the alkaline phosphatase family
DWQ65_RS01535	COG1136	(ABC) transporter
DWQ65_RS01555	COG1132	(ABC) transporter
DWQ65_RS01560	COG1132	(ABC) transporter
DWQ65_RS01575	COG0525	valine-tRNA ligase activity
DWQ65_RS01590	COG0737	Belongs to the 5'-nucleotidase family
DWQ65_RS01595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DWQ65_RS01600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DWQ65_RS01605	COG3437	response regulator, receiver
DWQ65_RS01610	COG1671	Belongs to the UPF0178 family
DWQ65_RS01620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DWQ65_RS01630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DWQ65_RS01645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWQ65_RS01650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWQ65_RS01665	COG0237	dephospho-CoA kinase activity
DWQ65_RS01670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DWQ65_RS01675	COG0710	3-dehydroquinate dehydratase activity
DWQ65_RS01675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DWQ65_RS01690	COG2095	MarC family integral membrane protein
DWQ65_RS01695	COG2801	Transposase and inactivated derivatives
DWQ65_RS01700	COG2801	Transposase and inactivated derivatives
DWQ65_RS01730	COG1070	Carbohydrate kinase
DWQ65_RS01740	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DWQ65_RS01745	COG1739	Uncharacterized protein family UPF0029
DWQ65_RS01760	COG0756	dUTP diphosphatase activity
DWQ65_RS01765	COG1185	polyribonucleotide nucleotidyltransferase activity
DWQ65_RS01775	COG0196	riboflavin kinase activity
DWQ65_RS01785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DWQ65_RS01790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DWQ65_RS01800	COG0779	Required for maturation of 30S ribosomal subunits
DWQ65_RS01805	COG0343	queuine tRNA-ribosyltransferase activity
DWQ65_RS01815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DWQ65_RS01845	COG1368	sulfuric ester hydrolase activity
DWQ65_RS01850	COG1368	sulfuric ester hydrolase activity
DWQ65_RS01870	COG1802	Transcriptional regulator
DWQ65_RS01880	COG0656	L-ascorbic acid biosynthetic process
DWQ65_RS01890	COG3842	ATPase activity
DWQ65_RS01895	COG0737	Belongs to the 5'-nucleotidase family
DWQ65_RS01915	COG1067	ATP-dependent peptidase activity
DWQ65_RS01945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWQ65_RS01945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWQ65_RS01950	COG1104	cysteine desulfurase activity
DWQ65_RS01955	COG0778	Nitroreductase
DWQ65_RS01965	COG2801	Transposase and inactivated derivatives
DWQ65_RS01995	COG0733	neurotransmitter:sodium symporter activity
DWQ65_RS02000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DWQ65_RS02010	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DWQ65_RS02030	COG2116	formate transmembrane transporter activity
DWQ65_RS02035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DWQ65_RS02055	COG3385	transposase activity
DWQ65_RS02115	COG0629	single-stranded DNA binding
DWQ65_RS02385	COG2339	peptidase activity
DWQ65_RS02390	COG0151	Belongs to the GarS family
DWQ65_RS02395	COG0138	bifunctional purine biosynthesis protein purh
DWQ65_RS02415	COG1509	lysine 2,3-aminomutase activity
DWQ65_RS02420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWQ65_RS02430	COG1177	transmembrane transport
DWQ65_RS02435	COG1176	ABC-type spermidine putrescine transport system, permease component I
DWQ65_RS02440	COG3842	ATPase activity
DWQ65_RS02445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWQ65_RS02455	COG0724	RNA recognition motif
DWQ65_RS02465	COG1979	alcohol dehydrogenase
DWQ65_RS02475	COG0791	NLP P60 protein
DWQ65_RS02475	COG1388	LysM domain
DWQ65_RS02480	COG0318	PFAM AMP-dependent synthetase and ligase
DWQ65_RS02490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DWQ65_RS02490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWQ65_RS02495	COG0739	heme binding
DWQ65_RS02505	COG0295	cytidine deaminase activity
DWQ65_RS02515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWQ65_RS02530	COG1272	protein, Hemolysin III
DWQ65_RS02565	COG2239	Acts as a magnesium transporter
DWQ65_RS02570	COG0460	homoserine dehydrogenase
DWQ65_RS02575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DWQ65_RS02580	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DWQ65_RS02595	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DWQ65_RS02605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DWQ65_RS02610	COG4608	Belongs to the ABC transporter superfamily
DWQ65_RS02615	COG0444	Belongs to the ABC transporter superfamily
DWQ65_RS02625	COG0601	transmembrane transport
DWQ65_RS02635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWQ65_RS02640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DWQ65_RS02640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DWQ65_RS02655	COG0523	cobalamin synthesis protein
DWQ65_RS02665	COG1349	DNA-binding transcription factor activity
DWQ65_RS02675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWQ65_RS02680	COG0191	fructose-bisphosphate aldolase activity
DWQ65_RS02685	COG0673	inositol 2-dehydrogenase activity
DWQ65_RS02690	COG1228	amidohydrolase
DWQ65_RS02720	COG0432	Pfam Uncharacterised protein family UPF0047
DWQ65_RS02730	COG0513	Belongs to the DEAD box helicase family
DWQ65_RS02750	COG1131	(ABC) transporter
DWQ65_RS02765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWQ65_RS02780	COG1129	ABC transporter
DWQ65_RS02785	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWQ65_RS02795	COG0626	cystathionine gamma-synthase activity
DWQ65_RS02805	COG1175	transmembrane transport
DWQ65_RS02820	COG0617	tRNA 3'-terminal CCA addition
DWQ65_RS02835	COG0433	COG0433 Predicted ATPase
DWQ65_RS02870	COG3039	Transposase
DWQ65_RS02905	COG0840	transmembrane signaling receptor activity
DWQ65_RS02915	COG0778	Nitroreductase
DWQ65_RS02955	COG1744	ABC transporter substrate-binding protein PnrA-like
DWQ65_RS02960	COG3845	ABC transporter
DWQ65_RS02965	COG4603	Belongs to the binding-protein-dependent transport system permease family
DWQ65_RS02970	COG1079	Belongs to the binding-protein-dependent transport system permease family
DWQ65_RS02975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DWQ65_RS03080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWQ65_RS03500	COG0716	FMN binding
DWQ65_RS03510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWQ65_RS03520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWQ65_RS03525	COG0250	Participates in transcription elongation, termination and antitermination
DWQ65_RS03530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DWQ65_RS03535	COG0081	regulation of translation
DWQ65_RS03550	COG0085	RNA polymerase activity
DWQ65_RS03560	COG1394	ATPase activity, coupled to movement of substances
DWQ65_RS03570	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DWQ65_RS03575	COG0426	domain, Protein
DWQ65_RS03575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DWQ65_RS03580	COG2304	oxidoreductase activity
DWQ65_RS03595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWQ65_RS03595	COG0574	Belongs to the PEP-utilizing enzyme family
DWQ65_RS03605	COG1131	(ABC) transporter
DWQ65_RS03615	COG0180	Tryptophanyl-tRNA synthetase
DWQ65_RS03620	COG3735	TraB family
DWQ65_RS03625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DWQ65_RS03630	COG1187	pseudouridine synthase activity
DWQ65_RS03640	COG3700	Belongs to the class B bacterial acid phosphatase family
DWQ65_RS03645	COG0571	ribonuclease III activity
DWQ65_RS03650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWQ65_RS03655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DWQ65_RS03665	COG0563	adenylate kinase activity
DWQ65_RS03710	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DWQ65_RS03755	COG0531	amino acid
DWQ65_RS03770	COG0740	serine-type endopeptidase activity
DWQ65_RS03775	COG0543	2 iron, 2 sulfur cluster binding
DWQ65_RS03780	COG0493	'glutamate synthase
DWQ65_RS03795	COG2197	response regulator
DWQ65_RS03860	COG3385	transposase activity
DWQ65_RS03905	COG2226	methyltransferase
DWQ65_RS03910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWQ65_RS03920	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWQ65_RS03925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWQ65_RS03930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DWQ65_RS03930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DWQ65_RS03935	COG0739	heme binding
DWQ65_RS03945	COG1132	(ABC) transporter
DWQ65_RS03950	COG1132	(ABC) transporter
DWQ65_RS03955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DWQ65_RS03965	COG1187	pseudouridine synthase activity
DWQ65_RS03990	COG1132	(ABC) transporter
DWQ65_RS03995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DWQ65_RS04015	COG3706	GGDEF domain
DWQ65_RS04030	COG1413	lyase activity
DWQ65_RS04040	COG1012	belongs to the aldehyde dehydrogenase family
DWQ65_RS04045	COG0673	inositol 2-dehydrogenase activity
DWQ65_RS04050	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWQ65_RS04060	COG1879	ABC-type sugar transport system periplasmic component
DWQ65_RS04100	COG2610	gluconate transmembrane transporter activity
DWQ65_RS04105	COG1929	Belongs to the glycerate kinase type-1 family
DWQ65_RS04115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DWQ65_RS04120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWQ65_RS04135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DWQ65_RS04190	COG0110	maltose O-acetyltransferase activity
DWQ65_RS04200	COG3579	cysteine-type endopeptidase activity
DWQ65_RS04215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DWQ65_RS04230	COG3437	response regulator, receiver
DWQ65_RS04230	COG2770	Histidine kinase
DWQ65_RS04235	COG1214	PFAM Peptidase M22, glycoprotease
DWQ65_RS04240	COG0802	atpase or kinase
DWQ65_RS04245	COG0322	excinuclease ABC activity
DWQ65_RS04270	COG2885	chlorophyll binding
DWQ65_RS04280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DWQ65_RS04285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DWQ65_RS04295	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DWQ65_RS04295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DWQ65_RS04320	COG0564	pseudouridine synthase activity
DWQ65_RS04330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWQ65_RS04340	COG0488	(ABC) transporter
DWQ65_RS04340	COG0488	(ABC) transporter
DWQ65_RS04345	COG1573	uracil-dna glycosylase
DWQ65_RS04350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DWQ65_RS04355	COG1086	Polysaccharide biosynthesis protein
DWQ65_RS04375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DWQ65_RS04390	COG0017	Asparaginyl-tRNA synthetase
DWQ65_RS04400	COG0840	transmembrane signaling receptor activity
DWQ65_RS04405	COG3630	sodium ion export across plasma membrane
DWQ65_RS04410	COG0511	ligase activity, forming carbon-carbon bonds
DWQ65_RS04410	COG5016	pyruvate
DWQ65_RS04420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWQ65_RS04425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWQ65_RS04440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DWQ65_RS04445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DWQ65_RS04455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DWQ65_RS04460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWQ65_RS04465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DWQ65_RS04530	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DWQ65_RS04540	COG2233	PERMEase
DWQ65_RS04550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DWQ65_RS04555	COG3177	Filamentation induced by cAMP protein fic
DWQ65_RS04575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWQ65_RS04595	COG0542	response to heat
DWQ65_RS04605	COG0457	Tetratricopeptide repeat
DWQ65_RS04610	COG1475	DNA binding
DWQ65_RS04615	COG1438	arginine binding
DWQ65_RS04620	COG0251	oxidation-reduction process
DWQ65_RS04655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWQ65_RS04680	COG3475	LICD family
DWQ65_RS04715	COG0028	Belongs to the TPP enzyme family
DWQ65_RS04715	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
DWQ65_RS04755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DWQ65_RS04770	COG1178	ABC-type Fe3 transport system permease component
DWQ65_RS04775	COG3842	ATPase activity
DWQ65_RS04805	COG5001	Diguanylate cyclase
DWQ65_RS04805	COG5002	protein histidine kinase activity
DWQ65_RS04810	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DWQ65_RS04810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DWQ65_RS04820	COG3118	belongs to the thioredoxin family
DWQ65_RS04825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DWQ65_RS04835	COG1516	flagellar protein fliS
DWQ65_RS04850	COG0395	ABC-type sugar transport system, permease component
DWQ65_RS04860	COG4209	transmembrane transport
DWQ65_RS04865	COG1040	competence protein
DWQ65_RS04880	COG1388	LysM domain
DWQ65_RS04880	COG0741	lytic transglycosylase activity
DWQ65_RS04890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWQ65_RS04900	COG1475	DNA binding
DWQ65_RS04905	COG1192	Involved in chromosome partitioning
DWQ65_RS04910	COG4953	penicillin-binding protein 1C
DWQ65_RS04915	COG2373	Large extracellular alpha-helical protein
DWQ65_RS04920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWQ65_RS04935	COG2089	acid synthase
DWQ65_RS04945	COG0495	leucyl-tRNA aminoacylation
DWQ65_RS04950	COG0351	phosphomethylpyrimidine kinase
DWQ65_RS04960	COG0739	heme binding
DWQ65_RS04965	COG0739	heme binding
DWQ65_RS04990	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DWQ65_RS04995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DWQ65_RS05000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DWQ65_RS05015	COG1227	inorganic diphosphatase activity
DWQ65_RS05015	COG0517	IMP dehydrogenase activity
DWQ65_RS05025	COG0768	penicillin binding
DWQ65_RS05030	COG2604	Protein of unknown function DUF115
DWQ65_RS05050	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DWQ65_RS05055	COG1760	l-serine dehydratase
DWQ65_RS05060	COG1760	l-serine dehydratase
DWQ65_RS05065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWQ65_RS05065	COG0574	Belongs to the PEP-utilizing enzyme family
DWQ65_RS05075	COG1473	amidohydrolase
DWQ65_RS05100	COG1592	Rubrerythrin
DWQ65_RS05110	COG2604	Protein of unknown function DUF115
DWQ65_RS05115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DWQ65_RS05125	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWQ65_RS05130	COG1121	(ABC) transporter
DWQ65_RS05135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWQ65_RS05145	COG1473	amidohydrolase
DWQ65_RS05170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWQ65_RS05195	COG0552	protein localization to endoplasmic reticulum
DWQ65_RS05210	COG1136	(ABC) transporter
DWQ65_RS05225	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DWQ65_RS05245	COG0049	tRNA binding
DWQ65_RS05250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DWQ65_RS05255	COG1053	succinate dehydrogenase
DWQ65_RS05260	COG2081	HI0933 family
DWQ65_RS05265	COG0187	DNA topoisomerase II activity
DWQ65_RS05305	COG0534	Mate efflux family protein
DWQ65_RS05345	COG1285	pathogenesis
DWQ65_RS05350	COG3330	Domain of unknown function (DUF4912)
DWQ65_RS05365	COG0455	bacterial-type flagellum organization
DWQ65_RS05375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DWQ65_RS05400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DWQ65_RS05405	COG0740	serine-type endopeptidase activity
DWQ65_RS05410	COG0544	peptidyl-prolyl cis-trans isomerase activity
DWQ65_RS05455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DWQ65_RS05455	COG3116	cell division
DWQ65_RS05460	COG0084	hydrolase, TatD family'
DWQ65_RS05485	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DWQ65_RS05495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DWQ65_RS05505	COG0360	Binds together with S18 to 16S ribosomal RNA
DWQ65_RS05510	COG0629	single-stranded DNA binding
DWQ65_RS05515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWQ65_RS05520	COG0359	binds to the 23S rRNA
DWQ65_RS05525	COG0305	Participates in initiation and elongation during chromosome replication
DWQ65_RS05565	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DWQ65_RS05570	COG1160	GTP binding
DWQ65_RS05600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWQ65_RS05600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWQ65_RS05600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWQ65_RS05625	COG0484	heat shock protein binding
DWQ65_RS05630	COG0443	Heat shock 70 kDa protein
DWQ65_RS05635	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DWQ65_RS05640	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
DWQ65_RS05645	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DWQ65_RS05665	COG1269	ATP hydrolysis coupled proton transport
DWQ65_RS05670	COG1527	subunit (C
DWQ65_RS05680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWQ65_RS05680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWQ65_RS05680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWQ65_RS05685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWQ65_RS05700	COG2313	pseudouridylate synthase activity
DWQ65_RS05705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWQ65_RS05710	COG2001	Belongs to the MraZ family
DWQ65_RS05715	COG0275	rRNA processing
DWQ65_RS05725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DWQ65_RS05730	COG0772	Belongs to the SEDS family
DWQ65_RS05735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DWQ65_RS05745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DWQ65_RS05750	COG4974	Belongs to the 'phage' integrase family
DWQ65_RS05760	COG0758	DNA mediated transformation
DWQ65_RS05765	COG0551	DNA topoisomerase type I activity
DWQ65_RS05765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWQ65_RS05770	COG4974	Belongs to the 'phage' integrase family
DWQ65_RS05775	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DWQ65_RS05780	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DWQ65_RS05785	COG1815	bacterial-type flagellum-dependent cell motility
DWQ65_RS05800	COG1766	The M ring may be actively involved in energy transduction
DWQ65_RS05810	COG1317	bacterial-type flagellum organization
DWQ65_RS05815	COG1157	protein secretion by the type III secretion system
DWQ65_RS05825	COG0019	diaminopimelate decarboxylase activity
DWQ65_RS05835	COG0438	transferase activity, transferring glycosyl groups
DWQ65_RS05860	COG2186	Transcriptional regulator
DWQ65_RS05885	COG0277	FAD linked oxidase domain protein
DWQ65_RS05890	COG1490	D-aminoacyl-tRNA deacylase activity
DWQ65_RS05895	COG0193	aminoacyl-tRNA hydrolase activity
DWQ65_RS05915	COG1473	amidohydrolase
DWQ65_RS05930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DWQ65_RS05940	COG0545	Peptidyl-prolyl cis-trans isomerase
DWQ65_RS05960	COG2217	Heavy metal translocating P-type atpase
DWQ65_RS05965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWQ65_RS05970	COG0813	purine-nucleoside phosphorylase activity
DWQ65_RS05975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWQ65_RS05985	COG0840	transmembrane signaling receptor activity
DWQ65_RS06015	COG2801	Transposase and inactivated derivatives
DWQ65_RS06020	COG0205	6-phosphofructokinase activity
DWQ65_RS06025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DWQ65_RS06040	COG0142	geranyltranstransferase activity
DWQ65_RS06050	COG1692	metallophosphoesterase
DWQ65_RS06070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWQ65_RS06075	COG1286	toxin biosynthetic process
DWQ65_RS06080	COG0470	DNA polymerase III
DWQ65_RS06085	COG3852	Histidine kinase
DWQ65_RS06090	COG2204	response regulator
DWQ65_RS06140	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DWQ65_RS06140	COG1918	ferrous iron import across plasma membrane
DWQ65_RS06155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DWQ65_RS06155	COG0674	pyruvate-flavodoxin oxidoreductase activity
DWQ65_RS06155	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DWQ65_RS06155	COG1013	pyruvate-flavodoxin oxidoreductase activity
DWQ65_RS06180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWQ65_RS06195	COG1162	GTPase activity
DWQ65_RS06200	COG1193	negative regulation of DNA recombination
DWQ65_RS06210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DWQ65_RS06220	COG3951	Flagellar rod assembly protein muramidase FlgJ
DWQ65_RS06225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DWQ65_RS06235	COG1047	Peptidyl-prolyl cis-trans
DWQ65_RS06245	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DWQ65_RS06255	COG1309	transcriptional regulator
DWQ65_RS06260	COG0037	tRNA processing
DWQ65_RS06265	COG1879	ABC-type sugar transport system periplasmic component
DWQ65_RS06270	COG1692	metallophosphoesterase
DWQ65_RS06280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DWQ65_RS06295	COG1115	amino acid carrier protein
DWQ65_RS06305	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DWQ65_RS06325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DWQ65_RS06345	COG0530	calcium, potassium:sodium antiporter activity
DWQ65_RS06365	COG0321	lipoyl(octanoyl) transferase activity
DWQ65_RS06365	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DWQ65_RS06385	COG2204	response regulator
DWQ65_RS06390	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DWQ65_RS06400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DWQ65_RS06415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWQ65_RS06440	COG0405	Gamma-glutamyltransferase
DWQ65_RS06455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWQ65_RS06460	COG0587	DNA-directed DNA polymerase activity
DWQ65_RS06465	COG0762	integral membrane protein
DWQ65_RS06470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DWQ65_RS06475	COG0584	glycerophosphoryl diester phosphodiesterase
DWQ65_RS06480	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWQ65_RS06490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DWQ65_RS06495	COG0542	response to heat
DWQ65_RS06520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DWQ65_RS06525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DWQ65_RS06540	COG0826	peptidase U32
DWQ65_RS06560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DWQ65_RS06605	COG1366	Belongs to the anti-sigma-factor antagonist family
DWQ65_RS06615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DWQ65_RS06625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DWQ65_RS06630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DWQ65_RS06660	COG1640	4-alpha-glucanotransferase
DWQ65_RS06675	COG1136	(ABC) transporter
DWQ65_RS06680	COG0672	)-iron permease
DWQ65_RS06685	COG3470	protein probably involved in high-affinity Fe2 transport
DWQ65_RS06700	COG0577	efflux transmembrane transporter activity
DWQ65_RS06700	COG1136	(ABC) transporter
DWQ65_RS06715	COG1136	(ABC) transporter
DWQ65_RS06730	COG3976	FMN-binding domain protein
DWQ65_RS06730	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DWQ65_RS06735	COG2070	2-Nitropropane dioxygenase
DWQ65_RS06740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWQ65_RS06755	COG0739	heme binding
DWQ65_RS06770	COG0666	response to abiotic stimulus
DWQ65_RS06805	COG2502	aspartate--ammonia ligase
DWQ65_RS06810	COG1704	LemA family
DWQ65_RS06820	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DWQ65_RS06855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DWQ65_RS06860	COG0301	tRNA thio-modification
DWQ65_RS06875	COG4786	Flagellar basal body rod
DWQ65_RS06880	COG2188	Transcriptional regulator
DWQ65_RS06885	COG2190	(PTS) system
DWQ65_RS06885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWQ65_RS06885	COG1263	PTS System
DWQ65_RS06890	COG0561	phosphatase activity
DWQ65_RS06895	COG2723	6-phospho-beta-galactosidase activity
DWQ65_RS06905	COG0363	glucosamine-6-phosphate deaminase activity
DWQ65_RS06910	COG0714	Associated with various cellular activities
DWQ65_RS06920	COG1305	Transglutaminase-like
DWQ65_RS06925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DWQ65_RS06940	COG0706	membrane insertase activity
DWQ65_RS06945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DWQ65_RS06955	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DWQ65_RS06965	COG1640	4-alpha-glucanotransferase
DWQ65_RS06970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DWQ65_RS06980	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DWQ65_RS06985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWQ65_RS07000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DWQ65_RS07035	COG2932	Transcriptional regulator
DWQ65_RS07120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DWQ65_RS07135	COG4211	Belongs to the binding-protein-dependent transport system permease family
DWQ65_RS07140	COG1129	ABC transporter
DWQ65_RS07145	COG1879	ABC-type sugar transport system periplasmic component
DWQ65_RS07150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DWQ65_RS07155	COG2088	sporulation resulting in formation of a cellular spore
DWQ65_RS07165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DWQ65_RS07170	COG0037	tRNA processing
DWQ65_RS07175	COG0457	Tetratricopeptide repeat
DWQ65_RS07180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWQ65_RS07185	COG0481	GTPase activity
DWQ65_RS07190	COG0840	transmembrane signaling receptor activity
DWQ65_RS07205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DWQ65_RS07280	COG0297	glycogen (starch) synthase activity
DWQ65_RS07335	COG2738	Putative neutral zinc metallopeptidase
DWQ65_RS07365	COG2255	four-way junction helicase activity
DWQ65_RS07370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DWQ65_RS07380	COG1362	aminopeptidase activity
DWQ65_RS07390	COG1570	exodeoxyribonuclease VII activity
DWQ65_RS07415	COG4750	Nucleotidyl transferase
DWQ65_RS07420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DWQ65_RS07445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DWQ65_RS07450	COG0456	acetyltransferase
DWQ65_RS07450	COG1214	PFAM Peptidase M22, glycoprotease
DWQ65_RS07455	COG1811	Na channel or pump
DWQ65_RS07470	COG2059	Chromate
DWQ65_RS07495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DWQ65_RS07500	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWQ65_RS07510	COG1196	nuclear chromosome segregation
DWQ65_RS07520	COG2201	protein-glutamate methylesterase activity
DWQ65_RS07530	COG0835	chemotaxis
DWQ65_RS07535	COG2198	Histidine kinase
DWQ65_RS07535	COG0643	Histidine kinase
DWQ65_RS07560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DWQ65_RS07565	COG1882	Formate acetyltransferase
DWQ65_RS07580	COG1253	flavin adenine dinucleotide binding
DWQ65_RS07615	COG1757	Na H antiporter
DWQ65_RS07620	COG0357	Ribosomal RNA small subunit methyltransferase G
DWQ65_RS07640	COG0840	transmembrane signaling receptor activity
DWQ65_RS07665	COG0012	GTP binding
DWQ65_RS07675	COG1268	BioY protein
DWQ65_RS07680	COG1122	ATPase activity
DWQ65_RS07700	COG3959	Transketolase, thiamine diphosphate binding domain
DWQ65_RS07705	COG3958	Transketolase
DWQ65_RS07710	COG0584	glycerophosphoryl diester phosphodiesterase
DWQ65_RS07755	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
DWQ65_RS07785	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWQ65_RS07795	COG1132	(ABC) transporter
DWQ65_RS07800	COG1132	(ABC) transporter
DWQ65_RS07805	COG1132	(ABC) transporter
DWQ65_RS07810	COG1132	(ABC) transporter
DWQ65_RS07815	COG4608	Belongs to the ABC transporter superfamily
DWQ65_RS07820	COG0444	Belongs to the ABC transporter superfamily
DWQ65_RS07825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWQ65_RS07855	COG0492	ferredoxin-NADP+ reductase activity
DWQ65_RS07860	COG1472	Belongs to the glycosyl hydrolase 3 family
DWQ65_RS07875	COG0450	alkyl hydroperoxide reductase
DWQ65_RS07880	COG1349	DNA-binding transcription factor activity
DWQ65_RS07885	COG1105	Belongs to the carbohydrate kinase PfkB family
DWQ65_RS07890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWQ65_RS07890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWQ65_RS07890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWQ65_RS07895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWQ65_RS07920	COG0640	Transcriptional regulator
DWQ65_RS07930	COG2217	Heavy metal translocating P-type atpase
DWQ65_RS07940	COG3177	Filamentation induced by cAMP protein fic
DWQ65_RS07950	COG3385	transposase activity
DWQ65_RS07990	COG0210	DNA helicase
DWQ65_RS08000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWQ65_RS08005	COG1522	sequence-specific DNA binding
DWQ65_RS08010	COG0436	Aminotransferase
DWQ65_RS08015	COG1114	Component of the transport system for branched-chain amino acids
DWQ65_RS08020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DWQ65_RS08025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DWQ65_RS08030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWQ65_RS08045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DWQ65_RS08050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DWQ65_RS08055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DWQ65_RS08065	COG1696	Membrane protein involved in D-alanine export
DWQ65_RS08080	COG0655	NAD(P)H dehydrogenase (quinone) activity
DWQ65_RS08085	COG0840	transmembrane signaling receptor activity
DWQ65_RS08100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DWQ65_RS08115	COG1252	NADH dehydrogenase
DWQ65_RS08120	COG1960	acyl-CoA dehydrogenase activity
DWQ65_RS08125	COG2086	electron transfer activity
DWQ65_RS08130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DWQ65_RS08160	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DWQ65_RS08165	COG1480	7TM receptor with intracellular HD hydrolase
DWQ65_RS08170	COG1702	phosphate starvation-inducible protein PhoH
DWQ65_RS08175	COG0018	arginyl-trna synthetase
DWQ65_RS08180	COG2235	arginine
DWQ65_RS08185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DWQ65_RS08190	COG0549	Belongs to the carbamate kinase family
DWQ65_RS08200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWQ65_RS08205	COG0534	Mate efflux family protein
DWQ65_RS08210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DWQ65_RS08235	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DWQ65_RS08240	COG1966	Carbon starvation protein
DWQ65_RS08245	COG1722	exodeoxyribonuclease VII activity
DWQ65_RS08250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DWQ65_RS08255	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DWQ65_RS08260	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DWQ65_RS08280	COG0395	ABC-type sugar transport system, permease component
DWQ65_RS08290	COG1653	transport
DWQ65_RS08295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DWQ65_RS08305	COG2084	Dehydrogenase
DWQ65_RS08315	COG0330	HflC and HflK could
DWQ65_RS08345	COG2197	response regulator
DWQ65_RS08350	COG4585	Histidine kinase
DWQ65_RS08360	COG0166	Belongs to the GPI family
DWQ65_RS08365	COG2814	Major facilitator Superfamily
DWQ65_RS08370	COG2814	Major facilitator Superfamily
DWQ65_RS08410	COG0482	sulfurtransferase activity
DWQ65_RS08420	COG1674	ftsk spoiiie
DWQ65_RS08425	COG1968	undecaprenyl-diphosphatase activity
DWQ65_RS08435	COG0840	transmembrane signaling receptor activity
DWQ65_RS08440	COG0840	transmembrane signaling receptor activity
DWQ65_RS08460	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DWQ65_RS08465	COG1752	Esterase of the alpha-beta hydrolase superfamily
DWQ65_RS08470	COG5341	Protein conserved in bacteria
DWQ65_RS08490	COG0823	Involved in the tonB-independent uptake of proteins
DWQ65_RS08510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DWQ65_RS08510	COG0564	pseudouridine synthase activity
DWQ65_RS08565	COG0519	Catalyzes the synthesis of GMP from XMP
DWQ65_RS08575	COG0519	Catalyzes the synthesis of GMP from XMP
DWQ65_RS08600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DWQ65_RS08600	COG0515	serine threonine protein kinase
DWQ65_RS08605	COG0811	peptide transport
DWQ65_RS08610	COG0848	biopolymer transport protein
DWQ65_RS08635	COG0203	ribosomal protein L17
DWQ65_RS08640	COG0202	RNA polymerase activity
DWQ65_RS08645	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DWQ65_RS08655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DWQ65_RS08665	COG0200	Binds to the 23S rRNA
DWQ65_RS08670	COG1841	ribosomal large subunit assembly
DWQ65_RS08680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DWQ65_RS08685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DWQ65_RS08690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DWQ65_RS08700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DWQ65_RS08715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DWQ65_RS08720	COG0255	Belongs to the universal ribosomal protein uL29 family
DWQ65_RS08730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DWQ65_RS08735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DWQ65_RS08745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DWQ65_RS08750	COG0089	rRNA binding
DWQ65_RS08755	COG0088	Forms part of the polypeptide exit tunnel
DWQ65_RS08760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DWQ65_RS08765	COG0051	transcription antitermination factor activity, RNA binding
DWQ65_RS08770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWQ65_RS08780	COG2823	Periplasmic or secreted lipoprotein
DWQ65_RS08780	COG1652	LysM domain
DWQ65_RS08785	COG2033	superoxide reductase activity
DWQ65_RS08790	COG1078	dGTPase activity
DWQ65_RS08815	COG1774	PSP1 C-terminal conserved region
DWQ65_RS08830	COG0739	heme binding
DWQ65_RS08835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DWQ65_RS08845	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DWQ65_RS08860	COG1419	protein localization to endoplasmic reticulum
DWQ65_RS08865	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DWQ65_RS08870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DWQ65_RS08875	COG1684	flagellar biosynthetic protein fliR
DWQ65_RS08880	COG1987	bacterial-type flagellum assembly
DWQ65_RS08885	COG1338	Plays a role in the flagellum-specific transport system
DWQ65_RS08895	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DWQ65_RS08895	COG1776	CheC inhibitor of MCP methylation
DWQ65_RS08900	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DWQ65_RS08905	COG1580	Controls the rotational direction of flagella during chemotaxis
DWQ65_RS08910	COG1360	Flagellar Motor Protein
DWQ65_RS08930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DWQ65_RS08950	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DWQ65_RS08965	COG5278	phosphoserine phosphatase activity
DWQ65_RS08965	COG0840	transmembrane signaling receptor activity
DWQ65_RS08980	COG1164	Oligoendopeptidase f
DWQ65_RS08985	COG1690	Belongs to the RtcB family
DWQ65_RS08990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWQ65_RS08990	COG2213	PTS system mannitol-specific
DWQ65_RS08995	COG1349	DNA-binding transcription factor activity
DWQ65_RS09000	COG1063	alcohol dehydrogenase
DWQ65_RS09005	COG0235	Class ii aldolase
DWQ65_RS09010	COG0058	SHG alpha-glucan phosphorylase activity
DWQ65_RS09015	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DWQ65_RS09025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWQ65_RS09025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DWQ65_RS09025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWQ65_RS09055	COG1151	hydroxylamine reductase activity
DWQ65_RS09080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWQ65_RS09120	COG0656	L-ascorbic acid biosynthetic process
DWQ65_RS09155	COG4536	flavin adenine dinucleotide binding
DWQ65_RS09160	COG1253	flavin adenine dinucleotide binding
DWQ65_RS09165	COG0800	Aldolase
DWQ65_RS09190	COG3706	GGDEF domain
DWQ65_RS09195	COG3706	GGDEF domain
DWQ65_RS09210	COG1653	transport
DWQ65_RS09220	COG0395	ABC-type sugar transport system, permease component
DWQ65_RS09240	COG0556	nucleotide-excision repair
DWQ65_RS09255	COG1102	Psort location Cytoplasmic, score
DWQ65_RS09265	COG0840	transmembrane signaling receptor activity
DWQ65_RS09280	COG0419	ATPase involved in DNA repair
DWQ65_RS09285	COG0420	3'-5' exonuclease activity
DWQ65_RS09290	COG0840	transmembrane signaling receptor activity
DWQ65_RS09305	COG0018	arginyl-trna synthetase
DWQ65_RS09345	COG2183	response to ionizing radiation
DWQ65_RS09355	COG1747	RNA polymerase binding
DWQ65_RS09355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWQ65_RS09370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWQ65_RS09385	COG1454	alcohol dehydrogenase
DWQ65_RS09385	COG1012	belongs to the aldehyde dehydrogenase family
DWQ65_RS09395	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DWQ65_RS09400	COG0442	prolyl-tRNA aminoacylation
DWQ65_RS09415	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DWQ65_RS09430	COG0628	permease
DWQ65_RS09435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DWQ65_RS09445	COG1312	Catalyzes the dehydration of D-mannonate
DWQ65_RS09450	COG0246	Mannitol dehydrogenase
DWQ65_RS09470	COG1904	glucuronate isomerase
DWQ65_RS09475	COG3250	beta-galactosidase activity
DWQ65_RS09480	COG2211	Major facilitator Superfamily
DWQ65_RS09495	COG1349	DNA-binding transcription factor activity
DWQ65_RS09515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DWQ65_RS09520	COG0423	glycine-tRNA ligase activity
DWQ65_RS09530	COG0731	radical SAM domain protein
DWQ65_RS09540	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DWQ65_RS09560	COG4555	ABC transporter
DWQ65_RS09565	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWQ65_RS09570	COG0564	pseudouridine synthase activity
DWQ65_RS09575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DWQ65_RS09585	COG1924	4 iron, 4 sulfur cluster binding
DWQ65_RS09600	COG0765	amino acid transport
DWQ65_RS09605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWQ65_RS09610	COG0733	neurotransmitter:sodium symporter activity
DWQ65_RS09620	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DWQ65_RS09625	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DWQ65_RS09630	COG0592	DNA-directed DNA polymerase activity
DWQ65_RS09640	COG1687	branched-chain amino acid
DWQ65_RS09645	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DWQ65_RS09650	COG0116	Belongs to the methyltransferase superfamily
DWQ65_RS09675	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWQ65_RS09680	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DWQ65_RS09685	COG1129	ABC transporter
DWQ65_RS09695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWQ65_RS09705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DWQ65_RS09715	COG0670	Belongs to the BI1 family
DWQ65_RS09720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWQ65_RS09740	COG0822	iron-sulfur transferase activity
DWQ65_RS09745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWQ65_RS09750	COG0719	Fe-S assembly protein
DWQ65_RS09755	COG0719	Fe-S assembly protein
DWQ65_RS09785	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWQ65_RS09790	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWQ65_RS09795	COG1129	ABC transporter
DWQ65_RS09800	COG1879	ABC-type sugar transport system periplasmic component
DWQ65_RS09850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWQ65_RS09910	COG0488	(ABC) transporter
DWQ65_RS09915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DWQ65_RS09920	COG0793	Belongs to the peptidase S41A family
DWQ65_RS09925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DWQ65_RS09940	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DWQ65_RS09950	COG0673	inositol 2-dehydrogenase activity
DWQ65_RS09965	COG1191	sigma factor activity
DWQ65_RS09970	COG1847	R3H domain protein
DWQ65_RS09995	COG3956	TIGRFAM MazG family protein
DWQ65_RS10015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DWQ65_RS10020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DWQ65_RS10040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DWQ65_RS10055	COG1469	GTP cyclohydrolase I activity
DWQ65_RS10060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWQ65_RS10075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DWQ65_RS10085	COG0557	exoribonuclease II activity
DWQ65_RS10100	COG2376	Dihydroxyacetone kinase
DWQ65_RS10125	COG1129	ABC transporter
DWQ65_RS10145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DWQ65_RS10165	COG1234	tRNA 3'-trailer cleavage
DWQ65_RS10170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWQ65_RS10205	COG3885	ferrous iron binding
DWQ65_RS10205	COG2078	PFAM AMMECR1 domain protein
DWQ65_RS10210	COG1022	Amp-dependent synthetase and ligase
DWQ65_RS10215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DWQ65_RS10220	COG1486	melibiose metabolic process
DWQ65_RS10230	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
DWQ65_RS10235	COG2982	Protein involved in outer membrane biogenesis
DWQ65_RS10240	COG0697	spore germination
DWQ65_RS10245	COG0217	transcriptional regulatory protein
DWQ65_RS10255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DWQ65_RS10260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DWQ65_RS10265	COG0840	transmembrane signaling receptor activity
DWQ65_RS10280	COG3842	ATPase activity
DWQ65_RS10285	COG1178	ABC-type Fe3 transport system permease component
DWQ65_RS10290	COG3842	ATPase activity
DWQ65_RS10300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DWQ65_RS10305	COG2378	regulation of single-species biofilm formation
DWQ65_RS10400	COG0860	N-Acetylmuramoyl-L-alanine amidase
DWQ65_RS10425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DWQ65_RS10430	COG2885	chlorophyll binding
DWQ65_RS10450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWQ65_RS10460	COG1131	(ABC) transporter
DWQ65_RS10480	COG0701	Predicted permease
DWQ65_RS10490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DWQ65_RS10525	COG1137	ATPase activity
DWQ65_RS10545	COG3723	Recombinational DNA repair protein, rece pathway
DWQ65_RS10565	COG5377	YqaJ viral recombinase family
DWQ65_RS10580	COG1132	(ABC) transporter
DWQ65_RS10585	COG4988	ABC transporter
DWQ65_RS10595	COG3142	Participates in the control of copper homeostasis
DWQ65_RS10600	COG1335	isochorismatase
DWQ65_RS10625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DWQ65_RS10630	COG1012	belongs to the aldehyde dehydrogenase family
DWQ65_RS10640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWQ65_RS10665	COG1609	Transcriptional regulator
DWQ65_RS10675	COG0632	four-way junction helicase activity
DWQ65_RS10685	COG0457	Tetratricopeptide repeat
DWQ65_RS10690	COG0785	Cytochrome C biogenesis protein
DWQ65_RS10695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWQ65_RS10710	COG0840	transmembrane signaling receptor activity
DWQ65_RS10720	COG3976	FMN-binding domain protein
DWQ65_RS10720	COG1053	succinate dehydrogenase
DWQ65_RS10720	COG0431	NADPH-dependent FMN reductase
DWQ65_RS10735	COG0205	6-phosphofructokinase activity
DWQ65_RS10765	COG1477	protein flavinylation
DWQ65_RS10815	COG5433	transposase activity
DWQ65_RS10825	COG1074	ATP-dependent DNA helicase activity
DWQ65_RS10830	COG2887	Belongs to the helicase family. UvrD subfamily
DWQ65_RS10855	COG2201	protein-glutamate methylesterase activity
DWQ65_RS10875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWQ65_RS10880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DWQ65_RS10885	COG0215	cysteine-tRNA ligase activity
DWQ65_RS10900	COG1305	Transglutaminase-like
DWQ65_RS10905	COG0528	UMP kinase activity
DWQ65_RS10915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DWQ65_RS10920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DWQ65_RS10925	COG0784	Response regulator, receiver
DWQ65_RS10925	COG5002	protein histidine kinase activity
DWQ65_RS10925	COG2205	protein histidine kinase activity
DWQ65_RS10930	COG0457	Tetratricopeptide repeat
DWQ65_RS10935	COG0280	phosphate acetyltransferase
DWQ65_RS10940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWQ65_RS10945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DWQ65_RS10950	COG0517	IMP dehydrogenase activity
DWQ65_RS10950	COG0516	GMP reductase activity
DWQ65_RS11005	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DWQ65_RS11015	COG0084	hydrolase, TatD family'
DWQ65_RS11020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DWQ65_RS11025	COG3118	belongs to the thioredoxin family
DWQ65_RS11030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWQ65_RS11050	COG0860	N-Acetylmuramoyl-L-alanine amidase
DWQ65_RS11065	COG2357	RelA SpoT domain protein
DWQ65_RS11070	COG0268	Binds directly to 16S ribosomal RNA
DWQ65_RS11075	COG0776	regulation of translation
DWQ65_RS11080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DWQ65_RS11090	COG1546	Belongs to the CinA family
DWQ65_RS11090	COG1058	Belongs to the CinA family
DWQ65_RS11095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DWQ65_RS11100	COG0254	rRNA binding
DWQ65_RS11130	COG0395	ABC-type sugar transport system, permease component
DWQ65_RS11135	COG1175	transmembrane transport
DWQ65_RS11150	COG0395	ABC-type sugar transport system, permease component
DWQ65_RS11170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DWQ65_RS11175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWQ65_RS11175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWQ65_RS11195	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DWQ65_RS11210	COG0629	single-stranded DNA binding
DWQ65_RS11215	COG0205	6-phosphofructokinase activity
DWQ65_RS11225	COG0494	nUDIX hydrolase
DWQ65_RS11245	COG0488	(ABC) transporter
DWQ65_RS11250	COG0617	tRNA 3'-terminal CCA addition
DWQ65_RS11255	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DWQ65_RS11260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DWQ65_RS11260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DWQ65_RS11270	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DWQ65_RS11295	COG0616	signal peptide processing
DWQ65_RS11300	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DWQ65_RS11305	COG0681	Belongs to the peptidase S26 family
DWQ65_RS11325	COG0750	zinc metalloprotease
DWQ65_RS11330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DWQ65_RS11335	COG4589	Belongs to the CDS family
DWQ65_RS11340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWQ65_RS11345	COG0233	cytoplasmic translational termination
DWQ65_RS11350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DWQ65_RS11355	COG0052	Belongs to the universal ribosomal protein uS2 family
DWQ65_RS11370	COG1136	(ABC) transporter
DWQ65_RS11375	COG0577	efflux transmembrane transporter activity
DWQ65_RS11380	COG0577	efflux transmembrane transporter activity
DWQ65_RS11385	COG0513	Belongs to the DEAD box helicase family
DWQ65_RS11395	COG1131	(ABC) transporter
DWQ65_RS11415	COG4585	Histidine kinase
DWQ65_RS11435	COG1136	(ABC) transporter
DWQ65_RS11460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DWQ65_RS11465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWQ65_RS11480	COG1254	Belongs to the acylphosphatase family
DWQ65_RS11505	COG0840	transmembrane signaling receptor activity
DWQ65_RS11525	COG0228	four-way junction DNA binding
DWQ65_RS11530	COG1837	Belongs to the UPF0109 family
DWQ65_RS11535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DWQ65_RS11540	COG0336	Belongs to the RNA methyltransferase TrmD family
DWQ65_RS11545	COG0335	large ribosomal subunit rRNA binding
DWQ65_RS11555	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DWQ65_RS11595	COG0210	DNA helicase
DWQ65_RS11600	COG0733	neurotransmitter:sodium symporter activity
DWQ65_RS11610	COG0561	phosphatase activity
DWQ65_RS11620	COG3681	Belongs to the UPF0597 family
DWQ65_RS11630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWQ65_RS11640	COG0142	geranyltranstransferase activity
DWQ65_RS11645	COG1609	Transcriptional regulator
DWQ65_RS11650	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
DWQ65_RS11660	COG0395	ABC-type sugar transport system, permease component
DWQ65_RS11665	COG4209	transmembrane transport
DWQ65_RS11670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWQ65_RS11675	COG2986	histidine ammonia-lyase
DWQ65_RS11680	COG3385	transposase activity
DWQ65_RS11685	COG2986	histidine ammonia-lyase
DWQ65_RS11690	COG0674	pyruvate-flavodoxin oxidoreductase activity
DWQ65_RS11690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DWQ65_RS11690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DWQ65_RS11690	COG1013	pyruvate-flavodoxin oxidoreductase activity
DWQ65_RS11695	COG0626	cystathionine gamma-synthase activity
DWQ65_RS11700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DWQ65_RS11705	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DWQ65_RS11710	COG1132	(ABC) transporter
DWQ65_RS11715	COG0653	protein targeting
DWQ65_RS11735	COG1366	Belongs to the anti-sigma-factor antagonist family
DWQ65_RS11750	COG0714	Associated with various cellular activities
DWQ65_RS11765	COG0569	domain protein
DWQ65_RS11770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWQ65_RS11775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWQ65_RS11780	COG3876	Protein conserved in bacteria
DWQ65_RS11815	COG0840	transmembrane signaling receptor activity
DWQ65_RS11835	COG0835	chemotaxis
DWQ65_RS11840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DWQ65_RS11845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DWQ65_RS11850	COG0497	DNA recombination
DWQ65_RS11865	COG0671	phosphoesterase, PA-phosphatase related
DWQ65_RS11870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DWQ65_RS11880	COG0601	transmembrane transport
DWQ65_RS11885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWQ65_RS11890	COG0444	Belongs to the ABC transporter superfamily
DWQ65_RS11895	COG4608	Belongs to the ABC transporter superfamily
DWQ65_RS11905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DWQ65_RS11925	COG3385	transposase activity
DWQ65_RS11930	COG0534	Mate efflux family protein
DWQ65_RS11935	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DWQ65_RS11945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DWQ65_RS11950	COG2911	Protein conserved in bacteria
DWQ65_RS11955	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWQ65_RS11965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DWQ65_RS11980	COG3037	sugar-specific permease SgaT UlaA
DWQ65_RS11990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWQ65_RS11990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWQ65_RS11995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWQ65_RS12025	COG1175	transmembrane transport
DWQ65_RS12030	COG0395	ABC-type sugar transport system, permease component
DWQ65_RS12035	COG0514	ATP-dependent DNA helicase (RecQ)
DWQ65_RS12060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWQ65_RS12070	COG1686	Belongs to the peptidase S11 family
DWQ65_RS12085	COG1418	mRNA catabolic process
DWQ65_RS12090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DWQ65_RS12115	COG2604	Protein of unknown function DUF115
DWQ65_RS12135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DWQ65_RS12145	COG0840	transmembrane signaling receptor activity
DWQ65_RS12165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DWQ65_RS12195	COG0517	IMP dehydrogenase activity
DWQ65_RS12200	COG0326	Molecular chaperone. Has ATPase activity
DWQ65_RS12215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DWQ65_RS12220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DWQ65_RS12225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DWQ65_RS12230	COG0300	oxidoreductase activity
DWQ65_RS12245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWQ65_RS12275	COG2003	Belongs to the UPF0758 family