locus-tag	class	description
C5O78_RS00010	COG1879	ABC-type sugar transport system periplasmic component
C5O78_RS00015	COG1692	metallophosphoesterase
C5O78_RS00025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5O78_RS00040	COG1115	amino acid carrier protein
C5O78_RS00050	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C5O78_RS00065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C5O78_RS00085	COG0530	calcium, potassium:sodium antiporter activity
C5O78_RS00105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5O78_RS00105	COG0321	lipoyl(octanoyl) transferase activity
C5O78_RS00125	COG2204	response regulator
C5O78_RS00130	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C5O78_RS00140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C5O78_RS00155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5O78_RS00180	COG0405	Gamma-glutamyltransferase
C5O78_RS00195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5O78_RS00200	COG0587	DNA-directed DNA polymerase activity
C5O78_RS00205	COG0762	integral membrane protein
C5O78_RS00210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5O78_RS00215	COG0584	glycerophosphoryl diester phosphodiesterase
C5O78_RS00220	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5O78_RS00230	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C5O78_RS00235	COG0542	response to heat
C5O78_RS00260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C5O78_RS00265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5O78_RS00275	COG0457	Tetratricopeptide repeat
C5O78_RS00280	COG1475	DNA binding
C5O78_RS00285	COG1438	arginine binding
C5O78_RS00290	COG0251	oxidation-reduction process
C5O78_RS00325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5O78_RS00365	COG2244	polysaccharide biosynthetic process
C5O78_RS00380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5O78_RS00425	COG0673	inositol 2-dehydrogenase activity
C5O78_RS00435	COG0028	Belongs to the TPP enzyme family
C5O78_RS00435	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
C5O78_RS00470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5O78_RS00485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5O78_RS00500	COG1178	ABC-type Fe3 transport system permease component
C5O78_RS00505	COG3842	ATPase activity
C5O78_RS00515	COG0363	glucosamine-6-phosphate deaminase activity
C5O78_RS00520	COG0714	Associated with various cellular activities
C5O78_RS00530	COG1305	Transglutaminase-like
C5O78_RS00535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5O78_RS00550	COG0706	membrane insertase activity
C5O78_RS00555	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5O78_RS00565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C5O78_RS00575	COG1640	4-alpha-glucanotransferase
C5O78_RS00580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5O78_RS00590	COG3328	transposase activity
C5O78_RS00595	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C5O78_RS00600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_RS00615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5O78_RS00650	COG2932	Transcriptional regulator
C5O78_RS01035	COG1879	ABC-type sugar transport system periplasmic component
C5O78_RS01040	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5O78_RS01045	COG1129	ABC transporter
C5O78_RS01050	COG1869	D-ribose catabolic process
C5O78_RS01075	COG0835	chemotaxis
C5O78_RS01080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5O78_RS01085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5O78_RS01090	COG0497	DNA recombination
C5O78_RS01105	COG0671	phosphoesterase, PA-phosphatase related
C5O78_RS01110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5O78_RS01120	COG0601	transmembrane transport
C5O78_RS01125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5O78_RS01130	COG0444	Belongs to the ABC transporter superfamily
C5O78_RS01135	COG4608	Belongs to the ABC transporter superfamily
C5O78_RS01145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5O78_RS01165	COG0534	Mate efflux family protein
C5O78_RS01170	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C5O78_RS01180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5O78_RS01185	COG2911	Protein conserved in bacteria
C5O78_RS01190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5O78_RS01200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5O78_RS01215	COG3037	sugar-specific permease SgaT UlaA
C5O78_RS01225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_RS01225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_RS01230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5O78_RS01260	COG1175	transmembrane transport
C5O78_RS01265	COG0395	ABC-type sugar transport system, permease component
C5O78_RS01270	COG0514	ATP-dependent DNA helicase (RecQ)
C5O78_RS01295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5O78_RS01305	COG1686	Belongs to the peptidase S11 family
C5O78_RS01320	COG1418	mRNA catabolic process
C5O78_RS01325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5O78_RS01350	COG2604	Protein of unknown function DUF115
C5O78_RS01370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C5O78_RS01405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C5O78_RS01410	COG4750	Nucleotidyl transferase
C5O78_RS01435	COG1570	exodeoxyribonuclease VII activity
C5O78_RS01445	COG1362	aminopeptidase activity
C5O78_RS01455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5O78_RS01460	COG2255	four-way junction helicase activity
C5O78_RS01490	COG2738	Putative neutral zinc metallopeptidase
C5O78_RS01540	COG0297	glycogen (starch) synthase activity
C5O78_RS01615	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C5O78_RS01625	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C5O78_RS01630	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C5O78_RS01635	COG1394	ATPase activity, coupled to movement of substances
C5O78_RS01640	COG1269	ATP hydrolysis coupled proton transport
C5O78_RS01650	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5O78_RS01655	COG2832	Protein of unknown function (DUF454)
C5O78_RS01660	COG0285	dihydrofolate synthase activity
C5O78_RS01685	COG0658	competence protein
C5O78_RS01685	COG2333	competence protein COMEC
C5O78_RS01710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5O78_RS01715	COG2890	protein-(glutamine-N5) methyltransferase activity
C5O78_RS01720	COG1022	Amp-dependent synthetase and ligase
C5O78_RS01725	COG1321	iron dependent repressor
C5O78_RS01730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5O78_RS01735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5O78_RS01740	COG1121	(ABC) transporter
C5O78_RS01745	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5O78_RS01750	COG1879	ABC-type sugar transport system periplasmic component
C5O78_RS01755	COG1129	ABC transporter
C5O78_RS01760	COG4211	Belongs to the binding-protein-dependent transport system permease family
C5O78_RS01775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5O78_RS01810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_RS01810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_RS01810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_RS01835	COG0484	heat shock protein binding
C5O78_RS01840	COG0443	Heat shock 70 kDa protein
C5O78_RS01845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5O78_RS01850	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C5O78_RS01855	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C5O78_RS01875	COG1269	ATP hydrolysis coupled proton transport
C5O78_RS01880	COG1527	subunit (C
C5O78_RS01890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_RS01890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_RS01890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_RS01895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5O78_RS01910	COG2313	pseudouridylate synthase activity
C5O78_RS01915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5O78_RS01920	COG2001	Belongs to the MraZ family
C5O78_RS01925	COG0275	rRNA processing
C5O78_RS01935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5O78_RS01940	COG0772	Belongs to the SEDS family
C5O78_RS01945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5O78_RS01955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5O78_RS01960	COG4974	Belongs to the 'phage' integrase family
C5O78_RS01970	COG0758	DNA mediated transformation
C5O78_RS01975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5O78_RS01975	COG0551	DNA topoisomerase type I activity
C5O78_RS01980	COG4974	Belongs to the 'phage' integrase family
C5O78_RS01985	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C5O78_RS01990	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C5O78_RS01995	COG1815	bacterial-type flagellum-dependent cell motility
C5O78_RS02010	COG1766	The M ring may be actively involved in energy transduction
C5O78_RS02020	COG1317	bacterial-type flagellum organization
C5O78_RS02025	COG1157	protein secretion by the type III secretion system
C5O78_RS02035	COG0019	diaminopimelate decarboxylase activity
C5O78_RS02045	COG0438	transferase activity, transferring glycosyl groups
C5O78_RS02070	COG2186	Transcriptional regulator
C5O78_RS02100	COG1490	D-aminoacyl-tRNA deacylase activity
C5O78_RS02105	COG0193	aminoacyl-tRNA hydrolase activity
C5O78_RS02125	COG1473	amidohydrolase
C5O78_RS02140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5O78_RS02150	COG0545	Peptidyl-prolyl cis-trans isomerase
C5O78_RS02170	COG2217	Heavy metal translocating P-type atpase
C5O78_RS02175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5O78_RS02180	COG0813	purine-nucleoside phosphorylase activity
C5O78_RS02185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5O78_RS02195	COG0840	transmembrane signaling receptor activity
C5O78_RS02230	COG5002	protein histidine kinase activity
C5O78_RS02240	COG0704	Plays a role in the regulation of phosphate uptake
C5O78_RS02245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5O78_RS02250	COG0581	inorganic phosphate transmembrane transporter activity
C5O78_RS02255	COG0573	inorganic phosphate transmembrane transporter activity
C5O78_RS02260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5O78_RS02290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5O78_RS02325	COG0305	Participates in initiation and elongation during chromosome replication
C5O78_RS02330	COG0359	binds to the 23S rRNA
C5O78_RS02335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5O78_RS02340	COG0629	single-stranded DNA binding
C5O78_RS02345	COG0360	Binds together with S18 to 16S ribosomal RNA
C5O78_RS02355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5O78_RS02365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5O78_RS02390	COG0084	hydrolase, TatD family'
C5O78_RS02395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5O78_RS02395	COG3116	cell division
C5O78_RS02440	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5O78_RS02445	COG0740	serine-type endopeptidase activity
C5O78_RS02450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5O78_RS02475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5O78_RS02485	COG0455	bacterial-type flagellum organization
C5O78_RS02500	COG3330	Domain of unknown function (DUF4912)
C5O78_RS02505	COG1285	pathogenesis
C5O78_RS02545	COG0534	Mate efflux family protein
C5O78_RS02585	COG0187	DNA topoisomerase II activity
C5O78_RS02590	COG2081	HI0933 family
C5O78_RS02595	COG1053	succinate dehydrogenase
C5O78_RS02600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5O78_RS02605	COG0049	tRNA binding
C5O78_RS02660	COG3621	Patatin-like phospholipase
C5O78_RS02725	COG0840	transmembrane signaling receptor activity
C5O78_RS02740	COG1132	(ABC) transporter
C5O78_RS02800	COG2197	response regulator
C5O78_RS02805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5O78_RS02825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C5O78_RS02835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C5O78_RS02850	COG0543	2 iron, 2 sulfur cluster binding
C5O78_RS02855	COG0167	dihydroorotate dehydrogenase activity
C5O78_RS02870	COG1199	ATP-dependent helicase activity
C5O78_RS02875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5O78_RS02880	COG0006	proline dipeptidase activity
C5O78_RS02890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5O78_RS02930	COG0484	heat shock protein binding
C5O78_RS02935	COG0024	Methionine aminopeptidase
C5O78_RS02950	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C5O78_RS02970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5O78_RS03010	COG0840	transmembrane signaling receptor activity
C5O78_RS03015	COG0431	NADPH-dependent FMN reductase
C5O78_RS03015	COG3976	FMN-binding domain protein
C5O78_RS03015	COG1053	succinate dehydrogenase
C5O78_RS03050	COG0840	transmembrane signaling receptor activity
C5O78_RS03070	COG0357	Ribosomal RNA small subunit methyltransferase G
C5O78_RS03075	COG1757	Na H antiporter
C5O78_RS03080	COG2801	Transposase and inactivated derivatives
C5O78_RS03110	COG0733	neurotransmitter:sodium symporter activity
C5O78_RS03115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5O78_RS03125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5O78_RS03145	COG2116	formate transmembrane transporter activity
C5O78_RS03150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5O78_RS03170	COG4536	flavin adenine dinucleotide binding
C5O78_RS03175	COG1253	flavin adenine dinucleotide binding
C5O78_RS03180	COG0800	Aldolase
C5O78_RS03200	COG3706	GGDEF domain
C5O78_RS03205	COG3706	GGDEF domain
C5O78_RS03220	COG1653	transport
C5O78_RS03230	COG0395	ABC-type sugar transport system, permease component
C5O78_RS03260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5O78_RS03280	COG2885	chlorophyll binding
C5O78_RS03315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5O78_RS03345	COG2056	Na+-H+ antiporter family
C5O78_RS03350	COG2986	histidine ammonia-lyase
C5O78_RS03365	COG3404	Formiminotransferase-cyclodeaminase
C5O78_RS03385	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5O78_RS03390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5O78_RS03400	COG0493	'glutamate synthase
C5O78_RS03400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5O78_RS03405	COG0402	S-adenosylhomocysteine deaminase activity
C5O78_RS03415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5O78_RS03420	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5O78_RS03420	COG3608	succinylglutamate desuccinylase aspartoacylase
C5O78_RS03425	COG1546	Belongs to the CinA family
C5O78_RS03425	COG1058	Belongs to the CinA family
C5O78_RS03430	COG0315	cyclic pyranopterin monophosphate synthase activity
C5O78_RS03445	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5O78_RS03455	COG0725	ABC transporter, periplasmic molybdate-binding protein
C5O78_RS03460	COG4149	molybdate abc transporter
C5O78_RS03465	COG3842	ATPase activity
C5O78_RS03470	COG0746	molybdenum cofactor guanylyltransferase activity
C5O78_RS03475	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5O78_RS03475	COG3608	succinylglutamate desuccinylase aspartoacylase
C5O78_RS03480	COG0709	Synthesizes selenophosphate from selenide and ATP
C5O78_RS03495	COG1104	cysteine desulfurase activity
C5O78_RS03505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5O78_RS03510	COG0772	Belongs to the SEDS family
C5O78_RS03515	COG0768	penicillin binding
C5O78_RS03530	COG1077	Cell shape determining protein MreB Mrl
C5O78_RS03550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5O78_RS03555	COG0358	DNA primase activity
C5O78_RS03560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5O78_RS03570	COG1234	tRNA 3'-trailer cleavage
C5O78_RS03590	COG4656	Part of a membrane complex involved in electron transport
C5O78_RS03595	COG4658	electron transport chain
C5O78_RS03605	COG4660	Part of a membrane complex involved in electron transport
C5O78_RS03610	COG4657	Part of a membrane complex involved in electron transport
C5O78_RS03615	COG1245	4Fe-4S binding domain
C5O78_RS03615	COG2878	Part of a membrane complex involved in electron transport
C5O78_RS03620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5O78_RS03630	COG1598	PFAM Uncharacterised protein family UPF0150
C5O78_RS03635	COG2211	Major facilitator Superfamily
C5O78_RS03640	COG3064	Membrane
C5O78_RS03685	COG1254	Belongs to the acylphosphatase family
C5O78_RS03695	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5O78_RS03700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C5O78_RS03725	COG1136	(ABC) transporter
C5O78_RS03745	COG4585	Histidine kinase
C5O78_RS03765	COG1131	(ABC) transporter
C5O78_RS03770	COG0513	Belongs to the DEAD box helicase family
C5O78_RS03775	COG0577	efflux transmembrane transporter activity
C5O78_RS03780	COG0577	efflux transmembrane transporter activity
C5O78_RS03785	COG1136	(ABC) transporter
C5O78_RS03800	COG0052	Belongs to the universal ribosomal protein uS2 family
C5O78_RS03805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5O78_RS03810	COG0233	cytoplasmic translational termination
C5O78_RS03815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5O78_RS03820	COG4589	Belongs to the CDS family
C5O78_RS03825	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5O78_RS03830	COG0750	zinc metalloprotease
C5O78_RS03850	COG0681	Belongs to the peptidase S26 family
C5O78_RS03855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5O78_RS03860	COG0616	signal peptide processing
C5O78_RS03875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5O78_RS03885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C5O78_RS03895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5O78_RS03895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5O78_RS03900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5O78_RS03905	COG0617	tRNA 3'-terminal CCA addition
C5O78_RS03915	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C5O78_RS03930	COG0629	single-stranded DNA binding
C5O78_RS03935	COG0205	6-phosphofructokinase activity
C5O78_RS03940	COG0494	nUDIX hydrolase
C5O78_RS03960	COG0488	(ABC) transporter
C5O78_RS03975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5O78_RS03980	COG0786	glutamate:sodium symporter activity
C5O78_RS03990	COG4770	biotin carboxylase activity
C5O78_RS03995	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C5O78_RS04000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5O78_RS04005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5O78_RS04010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5O78_RS04015	COG0786	glutamate:sodium symporter activity
C5O78_RS04025	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C5O78_RS04030	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C5O78_RS04040	COG4209	transmembrane transport
C5O78_RS04050	COG0395	ABC-type sugar transport system, permease component
C5O78_RS04075	COG4475	Protein of unknown function (DUF436)
C5O78_RS04120	COG1983	PspC domain protein
C5O78_RS04140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C5O78_RS04145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5O78_RS04150	COG0280	phosphate acetyltransferase
C5O78_RS04155	COG0457	Tetratricopeptide repeat
C5O78_RS04160	COG0784	Response regulator, receiver
C5O78_RS04160	COG2205	protein histidine kinase activity
C5O78_RS04160	COG5002	protein histidine kinase activity
C5O78_RS04165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5O78_RS04170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5O78_RS04180	COG0528	UMP kinase activity
C5O78_RS04185	COG1305	Transglutaminase-like
C5O78_RS04200	COG0215	cysteine-tRNA ligase activity
C5O78_RS04205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5O78_RS04210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5O78_RS04230	COG2201	protein-glutamate methylesterase activity
C5O78_RS04255	COG2887	Belongs to the helicase family. UvrD subfamily
C5O78_RS04260	COG1074	ATP-dependent DNA helicase activity
C5O78_RS04265	COG0840	transmembrane signaling receptor activity
C5O78_RS04270	COG5433	transposase activity
C5O78_RS04295	COG0217	transcriptional regulatory protein
C5O78_RS04305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5O78_RS04310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5O78_RS04315	COG0840	transmembrane signaling receptor activity
C5O78_RS04330	COG3842	ATPase activity
C5O78_RS04335	COG1178	ABC-type Fe3 transport system permease component
C5O78_RS04340	COG3842	ATPase activity
C5O78_RS04390	COG1253	flavin adenine dinucleotide binding
C5O78_RS04405	COG1882	Formate acetyltransferase
C5O78_RS04410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5O78_RS04435	COG2198	Histidine kinase
C5O78_RS04435	COG0643	Histidine kinase
C5O78_RS04440	COG0835	chemotaxis
C5O78_RS04450	COG2201	protein-glutamate methylesterase activity
C5O78_RS04460	COG1196	nuclear chromosome segregation
C5O78_RS04470	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5O78_RS04475	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C5O78_RS04500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5O78_RS04515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5O78_RS04520	COG2088	sporulation resulting in formation of a cellular spore
C5O78_RS04530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5O78_RS04535	COG0037	tRNA processing
C5O78_RS04540	COG0457	Tetratricopeptide repeat
C5O78_RS04545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5O78_RS04550	COG0481	GTPase activity
C5O78_RS04570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_RS04575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_RS04575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5O78_RS04575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_RS04580	COG1105	Belongs to the carbohydrate kinase PfkB family
C5O78_RS04585	COG1349	DNA-binding transcription factor activity
C5O78_RS04590	COG0450	alkyl hydroperoxide reductase
C5O78_RS04605	COG1472	Belongs to the glycosyl hydrolase 3 family
C5O78_RS04610	COG0492	ferredoxin-NADP+ reductase activity
C5O78_RS04640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5O78_RS04645	COG0444	Belongs to the ABC transporter superfamily
C5O78_RS04650	COG4608	Belongs to the ABC transporter superfamily
C5O78_RS04655	COG1132	(ABC) transporter
C5O78_RS04660	COG1132	(ABC) transporter
C5O78_RS04665	COG1132	(ABC) transporter
C5O78_RS04670	COG1132	(ABC) transporter
C5O78_RS04680	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5O78_RS04710	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C5O78_RS04750	COG0584	glycerophosphoryl diester phosphodiesterase
C5O78_RS04755	COG3958	Transketolase
C5O78_RS04760	COG3959	Transketolase, thiamine diphosphate binding domain
C5O78_RS04780	COG1122	ATPase activity
C5O78_RS04785	COG1268	BioY protein
C5O78_RS04790	COG0012	GTP binding
C5O78_RS04795	COG0205	6-phosphofructokinase activity
C5O78_RS04825	COG1477	protein flavinylation
C5O78_RS04865	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C5O78_RS04870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5O78_RS04875	COG0592	DNA-directed DNA polymerase activity
C5O78_RS04885	COG1687	branched-chain amino acid
C5O78_RS04890	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5O78_RS04895	COG0116	Belongs to the methyltransferase superfamily
C5O78_RS04920	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5O78_RS04930	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C5O78_RS04935	COG1129	ABC transporter
C5O78_RS04945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5O78_RS05015	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5O78_RS05020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5O78_RS05025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C5O78_RS05025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5O78_RS05030	COG0739	heme binding
C5O78_RS05040	COG1132	(ABC) transporter
C5O78_RS05045	COG1132	(ABC) transporter
C5O78_RS05050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5O78_RS05060	COG1187	pseudouridine synthase activity
C5O78_RS05085	COG1132	(ABC) transporter
C5O78_RS05090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5O78_RS05105	COG3706	GGDEF domain
C5O78_RS05120	COG1413	lyase activity
C5O78_RS05130	COG1012	belongs to the aldehyde dehydrogenase family
C5O78_RS05135	COG0673	inositol 2-dehydrogenase activity
C5O78_RS05140	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5O78_RS05150	COG1879	ABC-type sugar transport system periplasmic component
C5O78_RS05195	COG2610	gluconate transmembrane transporter activity
C5O78_RS05200	COG1929	Belongs to the glycerate kinase type-1 family
C5O78_RS05210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C5O78_RS05215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5O78_RS05230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5O78_RS05285	COG0110	maltose O-acetyltransferase activity
C5O78_RS05295	COG3579	cysteine-type endopeptidase activity
C5O78_RS05310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5O78_RS05325	COG3437	response regulator, receiver
C5O78_RS05325	COG2770	Histidine kinase
C5O78_RS05330	COG1214	PFAM Peptidase M22, glycoprotease
C5O78_RS05335	COG0802	atpase or kinase
C5O78_RS05340	COG0322	excinuclease ABC activity
C5O78_RS05365	COG2885	chlorophyll binding
C5O78_RS05375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5O78_RS05380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5O78_RS05390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5O78_RS05390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C5O78_RS05415	COG0564	pseudouridine synthase activity
C5O78_RS05425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5O78_RS05435	COG0488	(ABC) transporter
C5O78_RS05435	COG0488	(ABC) transporter
C5O78_RS05440	COG1573	uracil-dna glycosylase
C5O78_RS05445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5O78_RS05450	COG1086	Polysaccharide biosynthesis protein
C5O78_RS05455	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C5O78_RS05470	COG1136	(ABC) transporter
C5O78_RS05485	COG0552	protein localization to endoplasmic reticulum
C5O78_RS05515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C5O78_RS05520	COG3457	Alanine racemase
C5O78_RS05525	COG0626	cystathionine gamma-synthase activity
C5O78_RS05560	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5O78_RS05585	COG1473	amidohydrolase
C5O78_RS05595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5O78_RS05600	COG1121	(ABC) transporter
C5O78_RS05605	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5O78_RS05615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5O78_RS05620	COG2604	Protein of unknown function DUF115
C5O78_RS05630	COG1592	Rubrerythrin
C5O78_RS05655	COG1473	amidohydrolase
C5O78_RS05670	COG1760	l-serine dehydratase
C5O78_RS05675	COG1760	l-serine dehydratase
C5O78_RS05680	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C5O78_RS05955	COG1335	isochorismatase
C5O78_RS05960	COG3142	Participates in the control of copper homeostasis
C5O78_RS05970	COG4988	ABC transporter
C5O78_RS05975	COG1132	(ABC) transporter
C5O78_RS05980	COG1137	ATPase activity
C5O78_RS06015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5O78_RS06025	COG0701	Predicted permease
C5O78_RS06045	COG1131	(ABC) transporter
C5O78_RS06050	COG1028	Short-chain dehydrogenase reductase Sdr
C5O78_RS06060	COG0154	amidase activity
C5O78_RS06065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5O78_RS06070	COG0124	histidyl-tRNA synthetase
C5O78_RS06075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5O78_RS06080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5O78_RS06085	COG0579	oxidoreductase
C5O78_RS06100	COG0728	peptidoglycan biosynthetic process
C5O78_RS06105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5O78_RS06230	COG5001	Diguanylate cyclase
C5O78_RS06230	COG5002	protein histidine kinase activity
C5O78_RS06235	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C5O78_RS06235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5O78_RS06245	COG3118	belongs to the thioredoxin family
C5O78_RS06250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5O78_RS06260	COG1516	flagellar protein fliS
C5O78_RS06265	COG0840	transmembrane signaling receptor activity
C5O78_RS06285	COG1879	ABC-type sugar transport system periplasmic component
C5O78_RS06290	COG1129	ABC transporter
C5O78_RS06295	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5O78_RS06300	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5O78_RS06330	COG0719	Fe-S assembly protein
C5O78_RS06335	COG0719	Fe-S assembly protein
C5O78_RS06340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5O78_RS06345	COG0822	iron-sulfur transferase activity
C5O78_RS06365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5O78_RS06370	COG0670	Belongs to the BI1 family
C5O78_RS06380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5O78_RS06405	COG1366	Belongs to the anti-sigma-factor antagonist family
C5O78_RS06420	COG0714	Associated with various cellular activities
C5O78_RS06435	COG0569	domain protein
C5O78_RS06440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5O78_RS06445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5O78_RS06450	COG3876	Protein conserved in bacteria
C5O78_RS06490	COG3039	Transposase
C5O78_RS06495	COG0840	transmembrane signaling receptor activity
C5O78_RS06505	COG5433	transposase activity
C5O78_RS06515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5O78_RS06530	COG1252	NADH dehydrogenase
C5O78_RS06535	COG1960	acyl-CoA dehydrogenase activity
C5O78_RS06540	COG2086	electron transfer activity
C5O78_RS06545	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5O78_RS06570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5O78_RS06575	COG1480	7TM receptor with intracellular HD hydrolase
C5O78_RS06580	COG1702	phosphate starvation-inducible protein PhoH
C5O78_RS06585	COG0018	arginyl-trna synthetase
C5O78_RS06595	COG0419	ATPase involved in DNA repair
C5O78_RS06600	COG0420	3'-5' exonuclease activity
C5O78_RS06605	COG0840	transmembrane signaling receptor activity
C5O78_RS06660	COG0571	ribonuclease III activity
C5O78_RS06665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5O78_RS06670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5O78_RS06680	COG0563	adenylate kinase activity
C5O78_RS06720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5O78_RS06755	COG0531	amino acid
C5O78_RS06770	COG0740	serine-type endopeptidase activity
C5O78_RS06775	COG0543	2 iron, 2 sulfur cluster binding
C5O78_RS06780	COG0493	'glutamate synthase
C5O78_RS06795	COG2197	response regulator
C5O78_RS06815	COG0733	neurotransmitter:sodium symporter activity
C5O78_RS06820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5O78_RS06825	COG0765	amino acid transport
C5O78_RS06840	COG1924	4 iron, 4 sulfur cluster binding
C5O78_RS06850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5O78_RS06855	COG0564	pseudouridine synthase activity
C5O78_RS06860	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5O78_RS06865	COG4555	ABC transporter
C5O78_RS06885	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C5O78_RS06895	COG0731	radical SAM domain protein
C5O78_RS06905	COG0423	glycine-tRNA ligase activity
C5O78_RS06910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5O78_RS06940	COG1271	oxidase subunit
C5O78_RS06945	COG1294	oxidase, subunit
C5O78_RS06950	COG4988	ABC transporter
C5O78_RS06955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C5O78_RS06960	COG0328	RNA-DNA hybrid ribonuclease activity
C5O78_RS06965	COG4443	Transcriptional Coactivator p15 (PC4)
C5O78_RS06975	COG0708	Exodeoxyribonuclease III
C5O78_RS06980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C5O78_RS06995	COG0183	Belongs to the thiolase family
C5O78_RS07000	COG1960	acyl-CoA dehydrogenase activity
C5O78_RS07010	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5O78_RS07015	COG1024	Enoyl-CoA hydratase
C5O78_RS07020	COG0427	acetyl-CoA hydrolase
C5O78_RS07030	COG0297	glycogen (starch) synthase activity
C5O78_RS07035	COG0101	tRNA pseudouridine synthase activity
C5O78_RS07055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C5O78_RS07060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5O78_RS07065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5O78_RS07080	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C5O78_RS07085	COG1214	PFAM Peptidase M22, glycoprotease
C5O78_RS07085	COG0456	acetyltransferase
C5O78_RS07090	COG1811	Na channel or pump
C5O78_RS07100	COG2059	Chromate
C5O78_RS07120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5O78_RS07130	COG1012	belongs to the aldehyde dehydrogenase family
C5O78_RS07140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5O78_RS07165	COG1609	Transcriptional regulator
C5O78_RS07175	COG0632	four-way junction helicase activity
C5O78_RS07185	COG0457	Tetratricopeptide repeat
C5O78_RS07205	COG0789	Transcriptional regulator
C5O78_RS07225	COG0588	phosphoglycerate mutase activity
C5O78_RS07230	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C5O78_RS07240	COG0149	triose-phosphate isomerase activity
C5O78_RS07245	COG0126	phosphoglycerate kinase activity
C5O78_RS07270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5O78_RS07275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5O78_RS07280	COG0826	peptidase U32
C5O78_RS07305	COG0433	COG0433 Predicted ATPase
C5O78_RS07320	COG0655	NAD(P)H dehydrogenase (quinone) activity
C5O78_RS07335	COG1696	Membrane protein involved in D-alanine export
C5O78_RS07345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5O78_RS07350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5O78_RS07355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5O78_RS07370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5O78_RS07375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C5O78_RS07380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C5O78_RS07385	COG1114	Component of the transport system for branched-chain amino acids
C5O78_RS07390	COG0436	Aminotransferase
C5O78_RS07395	COG1522	sequence-specific DNA binding
C5O78_RS07400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5O78_RS07425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C5O78_RS07445	COG1506	peptidase
C5O78_RS07445	COG0823	Involved in the tonB-independent uptake of proteins
C5O78_RS07445	COG4946	Tricorn protease homolog
C5O78_RS07450	COG0840	transmembrane signaling receptor activity
C5O78_RS07465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5O78_RS07480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5O78_RS07485	COG1469	GTP cyclohydrolase I activity
C5O78_RS07495	COG0863	Belongs to the N(4) N(6)-methyltransferase family
C5O78_RS07505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5O78_RS07520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5O78_RS07525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5O78_RS07545	COG3956	TIGRFAM MazG family protein
C5O78_RS07575	COG0716	FMN binding
C5O78_RS07585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5O78_RS07595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5O78_RS07600	COG0250	Participates in transcription elongation, termination and antitermination
C5O78_RS07605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5O78_RS07610	COG0081	regulation of translation
C5O78_RS07625	COG0085	RNA polymerase activity
C5O78_RS07635	COG1394	ATPase activity, coupled to movement of substances
C5O78_RS07645	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
C5O78_RS07650	COG0426	domain, Protein
C5O78_RS07650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5O78_RS07655	COG2304	oxidoreductase activity
C5O78_RS07670	COG0574	Belongs to the PEP-utilizing enzyme family
C5O78_RS07670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5O78_RS07680	COG1131	(ABC) transporter
C5O78_RS07690	COG0180	Tryptophanyl-tRNA synthetase
C5O78_RS07695	COG3735	TraB family
C5O78_RS07700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5O78_RS07715	COG3700	Belongs to the class B bacterial acid phosphatase family
C5O78_RS07735	COG2339	peptidase activity
C5O78_RS07740	COG0151	Belongs to the GarS family
C5O78_RS07745	COG0138	bifunctional purine biosynthesis protein purh
C5O78_RS07765	COG1509	lysine 2,3-aminomutase activity
C5O78_RS07770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5O78_RS07780	COG1177	transmembrane transport
C5O78_RS07785	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5O78_RS07790	COG3842	ATPase activity
C5O78_RS07795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5O78_RS07805	COG0724	RNA recognition motif
C5O78_RS07815	COG1979	alcohol dehydrogenase
C5O78_RS07825	COG1388	LysM domain
C5O78_RS07825	COG0791	NLP P60 protein
C5O78_RS07830	COG0318	PFAM AMP-dependent synthetase and ligase
C5O78_RS07840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5O78_RS07840	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5O78_RS07845	COG0739	heme binding
C5O78_RS07855	COG0295	cytidine deaminase activity
C5O78_RS07865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5O78_RS07885	COG1272	protein, Hemolysin III
C5O78_RS08075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5O78_RS08235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5O78_RS08235	COG0564	pseudouridine synthase activity
C5O78_RS08255	COG0823	Involved in the tonB-independent uptake of proteins
C5O78_RS08275	COG5341	Protein conserved in bacteria
C5O78_RS08280	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5O78_RS08285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C5O78_RS08305	COG1968	undecaprenyl-diphosphatase activity
C5O78_RS08310	COG1674	ftsk spoiiie
C5O78_RS08320	COG0482	sulfurtransferase activity
C5O78_RS08365	COG2814	Major facilitator Superfamily
C5O78_RS08370	COG0166	Belongs to the GPI family
C5O78_RS08380	COG4585	Histidine kinase
C5O78_RS08385	COG2197	response regulator
C5O78_RS08395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5O78_RS08415	COG0330	HflC and HflK could
C5O78_RS08425	COG2084	Dehydrogenase
C5O78_RS08435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5O78_RS08440	COG1653	transport
C5O78_RS08450	COG0395	ABC-type sugar transport system, permease component
C5O78_RS08475	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C5O78_RS08480	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5O78_RS08485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5O78_RS08490	COG1722	exodeoxyribonuclease VII activity
C5O78_RS08495	COG1966	Carbon starvation protein
C5O78_RS08500	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C5O78_RS08525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5O78_RS08530	COG0534	Mate efflux family protein
C5O78_RS08535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5O78_RS08545	COG0549	Belongs to the carbamate kinase family
C5O78_RS08550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5O78_RS08555	COG2235	arginine
C5O78_RS08575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5O78_RS08590	COG1747	RNA polymerase binding
C5O78_RS08590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5O78_RS08600	COG2183	response to ionizing radiation
C5O78_RS08620	COG0488	(ABC) transporter
C5O78_RS08625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5O78_RS08630	COG0793	Belongs to the peptidase S41A family
C5O78_RS08635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5O78_RS08650	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C5O78_RS08665	COG0673	inositol 2-dehydrogenase activity
C5O78_RS08680	COG1191	sigma factor activity
C5O78_RS08685	COG1847	R3H domain protein
C5O78_RS08710	COG0840	transmembrane signaling receptor activity
C5O78_RS08730	COG0840	transmembrane signaling receptor activity
C5O78_RS08835	COG0840	transmembrane signaling receptor activity
C5O78_RS08845	COG0778	Nitroreductase
C5O78_RS08905	COG1132	(ABC) transporter
C5O78_RS08910	COG1132	(ABC) transporter
C5O78_RS08915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5O78_RS08920	COG1120	ATPase activity
C5O78_RS08955	COG0785	Cytochrome C biogenesis protein
C5O78_RS08960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5O78_RS09010	COG1979	alcohol dehydrogenase
C5O78_RS09020	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5O78_RS09025	COG0786	glutamate:sodium symporter activity
C5O78_RS09035	COG2378	regulation of single-species biofilm formation
C5O78_RS09085	COG0519	Catalyzes the synthesis of GMP from XMP
C5O78_RS09095	COG0519	Catalyzes the synthesis of GMP from XMP
C5O78_RS09165	COG0210	DNA helicase
C5O78_RS09200	COG2226	methyltransferase
C5O78_RS09240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5O78_RS09260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5O78_RS09275	COG1744	ABC transporter substrate-binding protein PnrA-like
C5O78_RS09280	COG3845	ABC transporter
C5O78_RS09285	COG4603	Belongs to the binding-protein-dependent transport system permease family
C5O78_RS09290	COG1079	Belongs to the binding-protein-dependent transport system permease family
C5O78_RS09315	COG1346	cytolysis
C5O78_RS09330	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
C5O78_RS09350	COG0191	fructose-bisphosphate aldolase activity
C5O78_RS09375	COG4166	transmembrane transport
C5O78_RS09390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5O78_RS09410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5O78_RS09415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5O78_RS09420	COG1862	Preprotein translocase
C5O78_RS09425	COG1639	'signal transduction protein
C5O78_RS09435	COG4115	mRNA cleavage
C5O78_RS09460	COG3885	ferrous iron binding
C5O78_RS09460	COG2078	PFAM AMMECR1 domain protein
C5O78_RS09465	COG1022	Amp-dependent synthetase and ligase
C5O78_RS09470	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C5O78_RS09475	COG1486	melibiose metabolic process
C5O78_RS09485	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
C5O78_RS09490	COG2982	Protein involved in outer membrane biogenesis
C5O78_RS09495	COG0697	spore germination
C5O78_RS09505	COG2723	6-phospho-beta-galactosidase activity
C5O78_RS09510	COG0561	phosphatase activity
C5O78_RS09515	COG1263	PTS System
C5O78_RS09515	COG2190	(PTS) system
C5O78_RS09515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5O78_RS09520	COG2188	Transcriptional regulator
C5O78_RS09525	COG4786	Flagellar basal body rod
C5O78_RS09540	COG0301	tRNA thio-modification
C5O78_RS09545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5O78_RS09570	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C5O78_RS09580	COG1704	LemA family
C5O78_RS09585	COG2502	aspartate--ammonia ligase
C5O78_RS09620	COG0666	response to abiotic stimulus
C5O78_RS09635	COG0739	heme binding
C5O78_RS09650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5O78_RS09655	COG2070	2-Nitropropane dioxygenase
C5O78_RS09660	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C5O78_RS09660	COG3976	FMN-binding domain protein
C5O78_RS09680	COG1136	(ABC) transporter
C5O78_RS09695	COG0577	efflux transmembrane transporter activity
C5O78_RS09695	COG1136	(ABC) transporter
C5O78_RS09710	COG3470	protein probably involved in high-affinity Fe2 transport
C5O78_RS09715	COG0672	)-iron permease
C5O78_RS09720	COG1136	(ABC) transporter
C5O78_RS09735	COG1640	4-alpha-glucanotransferase
C5O78_RS09765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5O78_RS09770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5O78_RS09780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5O78_RS09790	COG1366	Belongs to the anti-sigma-factor antagonist family
C5O78_RS09835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5O78_RS09855	COG0826	peptidase U32
C5O78_RS09865	COG2985	domain, Protein
C5O78_RS09865	COG0569	domain protein
C5O78_RS09875	COG0542	response to heat
C5O78_RS09895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5O78_RS09910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5O78_RS09925	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C5O78_RS09985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5O78_RS09995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5O78_RS10000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5O78_RS10010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5O78_RS10015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5O78_RS10030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5O78_RS10040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5O78_RS10050	COG5016	pyruvate
C5O78_RS10050	COG0511	ligase activity, forming carbon-carbon bonds
C5O78_RS10055	COG3630	sodium ion export across plasma membrane
C5O78_RS10060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5O78_RS10065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5O78_RS10070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C5O78_RS10075	COG0300	oxidoreductase activity
C5O78_RS10090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5O78_RS10120	COG2003	Belongs to the UPF0758 family
C5O78_RS10135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5O78_RS10160	COG2801	Transposase and inactivated derivatives
C5O78_RS10290	COG0228	four-way junction DNA binding
C5O78_RS10295	COG1837	Belongs to the UPF0109 family
C5O78_RS10300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5O78_RS10305	COG0336	Belongs to the RNA methyltransferase TrmD family
C5O78_RS10310	COG0335	large ribosomal subunit rRNA binding
C5O78_RS10320	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5O78_RS10360	COG0210	DNA helicase
C5O78_RS10365	COG0733	neurotransmitter:sodium symporter activity
C5O78_RS10375	COG0561	phosphatase activity
C5O78_RS10385	COG3681	Belongs to the UPF0597 family
C5O78_RS10395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5O78_RS10405	COG0142	geranyltranstransferase activity
C5O78_RS10410	COG1609	Transcriptional regulator
C5O78_RS10415	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C5O78_RS10425	COG0395	ABC-type sugar transport system, permease component
C5O78_RS10430	COG4209	transmembrane transport
C5O78_RS10435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5O78_RS10440	COG2986	histidine ammonia-lyase
C5O78_RS10445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5O78_RS10445	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5O78_RS10445	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5O78_RS10445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5O78_RS10450	COG0626	cystathionine gamma-synthase activity
C5O78_RS10455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5O78_RS10460	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C5O78_RS10465	COG1132	(ABC) transporter
C5O78_RS10470	COG0653	protein targeting
C5O78_RS10475	COG2801	Transposase and inactivated derivatives
C5O78_RS10485	COG0556	nucleotide-excision repair
C5O78_RS10500	COG1102	Psort location Cytoplasmic, score
C5O78_RS10510	COG0840	transmembrane signaling receptor activity
C5O78_RS10520	COG2801	Transposase and inactivated derivatives
C5O78_RS10530	COG0778	Nitroreductase
C5O78_RS10535	COG1104	cysteine desulfurase activity
C5O78_RS10540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5O78_RS10540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5O78_RS10565	COG1067	ATP-dependent peptidase activity
C5O78_RS10585	COG0737	Belongs to the 5'-nucleotidase family
C5O78_RS10590	COG3842	ATPase activity
C5O78_RS10600	COG0656	L-ascorbic acid biosynthetic process
C5O78_RS10610	COG1802	Transcriptional regulator
C5O78_RS10630	COG1368	sulfuric ester hydrolase activity
C5O78_RS10635	COG1368	sulfuric ester hydrolase activity
C5O78_RS10665	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C5O78_RS10675	COG0343	queuine tRNA-ribosyltransferase activity
C5O78_RS10680	COG0779	Required for maturation of 30S ribosomal subunits
C5O78_RS10690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5O78_RS10695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5O78_RS10705	COG0196	riboflavin kinase activity
C5O78_RS10715	COG1185	polyribonucleotide nucleotidyltransferase activity
C5O78_RS10720	COG0756	dUTP diphosphatase activity
C5O78_RS10735	COG1739	Uncharacterized protein family UPF0029
C5O78_RS10740	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C5O78_RS10750	COG1070	Carbohydrate kinase
C5O78_RS10765	COG2801	Transposase and inactivated derivatives
C5O78_RS10770	COG2801	Transposase and inactivated derivatives
C5O78_RS10775	COG2095	MarC family integral membrane protein
C5O78_RS10785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5O78_RS10790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5O78_RS10795	COG0737	Belongs to the 5'-nucleotidase family
C5O78_RS10805	COG0525	valine-tRNA ligase activity
C5O78_RS10820	COG1132	(ABC) transporter
C5O78_RS10825	COG1132	(ABC) transporter
C5O78_RS10845	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5O78_RS10850	COG1132	(ABC) transporter
C5O78_RS10855	COG2375	cellular response to nickel ion
C5O78_RS10855	COG1132	(ABC) transporter
C5O78_RS10860	COG1309	transcriptional regulator
C5O78_RS10865	COG0517	IMP dehydrogenase activity
C5O78_RS10865	COG0516	GMP reductase activity
C5O78_RS10880	COG0840	transmembrane signaling receptor activity
C5O78_RS10900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5O78_RS10930	COG0517	IMP dehydrogenase activity
C5O78_RS10935	COG0326	Molecular chaperone. Has ATPase activity
C5O78_RS10950	COG0840	transmembrane signaling receptor activity
C5O78_RS10955	COG0017	Asparaginyl-tRNA synthetase
C5O78_RS10970	COG1744	ABC transporter substrate-binding protein PnrA-like
C5O78_RS10975	COG3845	ABC transporter
C5O78_RS10980	COG4603	Belongs to the binding-protein-dependent transport system permease family
C5O78_RS10985	COG1079	Belongs to the binding-protein-dependent transport system permease family
C5O78_RS10990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5O78_RS11020	COG0656	L-ascorbic acid biosynthetic process
C5O78_RS11055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5O78_RS11065	COG2801	Transposase and inactivated derivatives
C5O78_RS11090	COG3385	transposase activity
C5O78_RS11100	COG3177	Filamentation induced by cAMP protein fic
C5O78_RS11110	COG2217	Heavy metal translocating P-type atpase
C5O78_RS11120	COG0640	Transcriptional regulator
C5O78_RS11170	COG0395	ABC-type sugar transport system, permease component
C5O78_RS11175	COG4209	transmembrane transport
C5O78_RS11180	COG1040	competence protein
C5O78_RS11195	COG0741	lytic transglycosylase activity
C5O78_RS11195	COG1388	LysM domain
C5O78_RS11205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5O78_RS11215	COG1475	DNA binding
C5O78_RS11220	COG1192	Involved in chromosome partitioning
C5O78_RS11225	COG4953	penicillin-binding protein 1C
C5O78_RS11230	COG2373	Large extracellular alpha-helical protein
C5O78_RS11235	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5O78_RS11250	COG2089	acid synthase
C5O78_RS11260	COG0495	leucyl-tRNA aminoacylation
C5O78_RS11265	COG0351	phosphomethylpyrimidine kinase
C5O78_RS11275	COG0739	heme binding
C5O78_RS11280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C5O78_RS11285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5O78_RS11290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C5O78_RS11315	COG0739	heme binding
C5O78_RS11330	COG0517	IMP dehydrogenase activity
C5O78_RS11330	COG1227	inorganic diphosphatase activity
C5O78_RS11340	COG0768	penicillin binding
C5O78_RS11345	COG2604	Protein of unknown function DUF115
C5O78_RS11370	COG5377	YqaJ viral recombinase family
C5O78_RS11390	COG3723	Recombinational DNA repair protein, rece pathway
C5O78_RS11410	COG2376	Dihydroxyacetone kinase
C5O78_RS11425	COG0557	exoribonuclease II activity
C5O78_RS11445	COG1129	ABC transporter
C5O78_RS11465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5O78_RS11485	COG1234	tRNA 3'-trailer cleavage
C5O78_RS11490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5O78_RS11515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5O78_RS11525	COG0504	CTP synthase activity
C5O78_RS11530	COG1757	Na H antiporter
C5O78_RS11550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5O78_RS11560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5O78_RS11565	COG0765	amino acid transport
C5O78_RS11570	COG1126	abc transporter atp-binding protein
C5O78_RS11585	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C5O78_RS11595	COG1175	transmembrane transport
C5O78_RS11605	COG0330	HflC and HflK could
C5O78_RS11610	COG0330	HflC and HflK could
C5O78_RS11625	COG1785	Belongs to the alkaline phosphatase family
C5O78_RS11650	COG1136	(ABC) transporter
C5O78_RS11670	COG0037	tRNA processing
C5O78_RS11675	COG1309	transcriptional regulator
C5O78_RS11685	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C5O78_RS11695	COG1047	Peptidyl-prolyl cis-trans
C5O78_RS11705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5O78_RS11710	COG3951	Flagellar rod assembly protein muramidase FlgJ
C5O78_RS11720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5O78_RS11735	COG1193	negative regulation of DNA recombination
C5O78_RS11740	COG1162	GTPase activity
C5O78_RS11755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5O78_RS11780	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5O78_RS11780	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5O78_RS11780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5O78_RS11780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C5O78_RS11795	COG1918	ferrous iron import across plasma membrane
C5O78_RS11795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C5O78_RS11845	COG2204	response regulator
C5O78_RS11850	COG3852	Histidine kinase
C5O78_RS11855	COG0470	DNA polymerase III
C5O78_RS11860	COG1286	toxin biosynthetic process
C5O78_RS11865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5O78_RS11885	COG1692	metallophosphoesterase
C5O78_RS11895	COG0142	geranyltranstransferase activity
C5O78_RS11910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5O78_RS11915	COG0205	6-phosphofructokinase activity
C5O78_RS11920	COG2801	Transposase and inactivated derivatives
C5O78_RS11940	COG2239	Acts as a magnesium transporter
C5O78_RS11945	COG0460	homoserine dehydrogenase
C5O78_RS11950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5O78_RS11955	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C5O78_RS11970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C5O78_RS11980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5O78_RS11985	COG4608	Belongs to the ABC transporter superfamily
C5O78_RS11990	COG0444	Belongs to the ABC transporter superfamily
C5O78_RS12000	COG0601	transmembrane transport
C5O78_RS12010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5O78_RS12015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5O78_RS12015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5O78_RS12030	COG0523	cobalamin synthesis protein
C5O78_RS12040	COG1349	DNA-binding transcription factor activity
C5O78_RS12050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5O78_RS12055	COG0191	fructose-bisphosphate aldolase activity
C5O78_RS12060	COG0673	inositol 2-dehydrogenase activity
C5O78_RS12065	COG1228	amidohydrolase
C5O78_RS12095	COG0432	Pfam Uncharacterised protein family UPF0047
C5O78_RS12105	COG0513	Belongs to the DEAD box helicase family
C5O78_RS12125	COG1131	(ABC) transporter
C5O78_RS12140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5O78_RS12155	COG1129	ABC transporter
C5O78_RS12160	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5O78_RS12170	COG0617	tRNA 3'-terminal CCA addition
C5O78_RS12175	COG0668	transmembrane transport
C5O78_RS12215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5O78_RS12225	COG0084	hydrolase, TatD family'
C5O78_RS12230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5O78_RS12235	COG3118	belongs to the thioredoxin family
C5O78_RS12240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5O78_RS12260	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5O78_RS12275	COG2357	RelA SpoT domain protein
C5O78_RS12280	COG0268	Binds directly to 16S ribosomal RNA
C5O78_RS12285	COG0776	regulation of translation
C5O78_RS12290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C5O78_RS12300	COG1546	Belongs to the CinA family
C5O78_RS12300	COG1058	Belongs to the CinA family
C5O78_RS12305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5O78_RS12310	COG0254	rRNA binding
C5O78_RS12340	COG0395	ABC-type sugar transport system, permease component
C5O78_RS12345	COG1175	transmembrane transport
C5O78_RS12360	COG0395	ABC-type sugar transport system, permease component
C5O78_RS12375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5O78_RS12380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5O78_RS12380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5O78_RS12410	COG0515	serine threonine protein kinase
C5O78_RS12410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5O78_RS12415	COG0811	peptide transport
C5O78_RS12420	COG0848	biopolymer transport protein
C5O78_RS12445	COG0203	ribosomal protein L17
C5O78_RS12450	COG0202	RNA polymerase activity
C5O78_RS12455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5O78_RS12465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5O78_RS12475	COG0200	Binds to the 23S rRNA
C5O78_RS12480	COG1841	ribosomal large subunit assembly
C5O78_RS12490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5O78_RS12495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5O78_RS12500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5O78_RS12510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5O78_RS12525	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5O78_RS12530	COG0255	Belongs to the universal ribosomal protein uL29 family
C5O78_RS12540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5O78_RS12545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5O78_RS12555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5O78_RS12560	COG0089	rRNA binding
C5O78_RS12565	COG0088	Forms part of the polypeptide exit tunnel
C5O78_RS12570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5O78_RS12575	COG0051	transcription antitermination factor activity, RNA binding
C5O78_RS12580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5O78_RS12590	COG1652	LysM domain
C5O78_RS12590	COG2823	Periplasmic or secreted lipoprotein
C5O78_RS12595	COG2033	superoxide reductase activity
C5O78_RS12600	COG1078	dGTPase activity
C5O78_RS12630	COG1774	PSP1 C-terminal conserved region
C5O78_RS12645	COG0739	heme binding
C5O78_RS12650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5O78_RS12660	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C5O78_RS12675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5O78_RS12675	COG0710	3-dehydroquinate dehydratase activity
C5O78_RS12680	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C5O78_RS12685	COG0237	dephospho-CoA kinase activity
C5O78_RS12700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5O78_RS12705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5O78_RS12720	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5O78_RS12730	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C5O78_RS12740	COG1671	Belongs to the UPF0178 family
C5O78_RS12745	COG3437	response regulator, receiver
C5O78_RS12755	COG1419	protein localization to endoplasmic reticulum
C5O78_RS12760	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5O78_RS12765	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5O78_RS12770	COG1684	flagellar biosynthetic protein fliR
C5O78_RS12775	COG1987	bacterial-type flagellum assembly
C5O78_RS12780	COG1338	Plays a role in the flagellum-specific transport system
C5O78_RS12790	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5O78_RS12790	COG1776	CheC inhibitor of MCP methylation
C5O78_RS12795	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5O78_RS12800	COG1580	Controls the rotational direction of flagella during chemotaxis
C5O78_RS12805	COG1360	Flagellar Motor Protein
C5O78_RS12825	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C5O78_RS12845	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C5O78_RS12855	COG0840	transmembrane signaling receptor activity
C5O78_RS12855	COG5278	phosphoserine phosphatase activity
C5O78_RS12870	COG1164	Oligoendopeptidase f
C5O78_RS12875	COG1690	Belongs to the RtcB family
C5O78_RS12880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5O78_RS12880	COG2213	PTS system mannitol-specific
C5O78_RS12885	COG1349	DNA-binding transcription factor activity
C5O78_RS12890	COG1063	alcohol dehydrogenase
C5O78_RS12895	COG0235	Class ii aldolase
C5O78_RS12900	COG0058	SHG alpha-glucan phosphorylase activity
C5O78_RS12905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C5O78_RS12915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5O78_RS12915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5O78_RS12915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5O78_RS12940	COG1151	hydroxylamine reductase activity
C5O78_RS12985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5O78_RS12990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5O78_RS13035	COG3052	prosthetic group binding
C5O78_RS13065	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C5O78_RS13070	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C5O78_RS13085	COG1129	ABC transporter
C5O78_RS13105	COG2226	methyltransferase
C5O78_RS13140	COG3177	Filamentation induced by cAMP protein fic
C5O78_RS13295	COG1454	alcohol dehydrogenase
C5O78_RS13295	COG1012	belongs to the aldehyde dehydrogenase family
C5O78_RS13305	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C5O78_RS13310	COG0442	prolyl-tRNA aminoacylation
C5O78_RS13325	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C5O78_RS13340	COG0628	permease
C5O78_RS13345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5O78_RS13355	COG1312	Catalyzes the dehydration of D-mannonate
C5O78_RS13360	COG0246	Mannitol dehydrogenase
C5O78_RS13380	COG1904	glucuronate isomerase
C5O78_RS13385	COG3250	beta-galactosidase activity
C5O78_RS13390	COG2211	Major facilitator Superfamily
C5O78_RS13405	COG1349	DNA-binding transcription factor activity