locus-tag	class	description
JO40_RS00020	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JO40_RS00030	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JO40_RS00035	COG0495	leucyl-tRNA aminoacylation
JO40_RS00045	COG0750	zinc metalloprotease
JO40_RS00050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JO40_RS00055	COG0575	Belongs to the CDS family
JO40_RS00060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JO40_RS00065	COG0233	cytoplasmic translational termination
JO40_RS00070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JO40_RS00075	COG0052	Belongs to the universal ribosomal protein uS2 family
JO40_RS00080	COG0424	maF-like protein
JO40_RS00085	COG1413	lyase activity
JO40_RS00105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JO40_RS00110	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
JO40_RS00115	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JO40_RS00125	COG1196	nuclear chromosome segregation
JO40_RS00125	COG0741	lytic transglycosylase activity
JO40_RS00125	COG0739	heme binding
JO40_RS00150	COG0668	transmembrane transport
JO40_RS00170	COG0840	transmembrane signaling receptor activity
JO40_RS00190	COG4166	transmembrane transport
JO40_RS00195	COG0601	transmembrane transport
JO40_RS00200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JO40_RS00205	COG0444	Belongs to the ABC transporter superfamily
JO40_RS00210	COG4172	Belongs to the ABC transporter superfamily
JO40_RS00215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JO40_RS00220	COG0709	Synthesizes selenophosphate from selenide and ATP
JO40_RS00235	COG0425	Belongs to the sulfur carrier protein TusA family
JO40_RS00250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JO40_RS00265	COG0601	transmembrane transport
JO40_RS00270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JO40_RS00275	COG0444	Belongs to the ABC transporter superfamily
JO40_RS00280	COG4608	Belongs to the ABC transporter superfamily
JO40_RS00300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JO40_RS00300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JO40_RS00320	COG0534	Mate efflux family protein
JO40_RS00325	COG0840	transmembrane signaling receptor activity
JO40_RS00330	COG1757	Na H antiporter
JO40_RS00340	COG3290	protein histidine kinase activity
JO40_RS00340	COG3829	transcription factor binding
JO40_RS00365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JO40_RS00370	COG0049	tRNA binding
JO40_RS00375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JO40_RS00390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JO40_RS00390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JO40_RS00390	COG1013	pyruvate-flavodoxin oxidoreductase activity
JO40_RS00390	COG0674	pyruvate-flavodoxin oxidoreductase activity
JO40_RS00395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JO40_RS00400	COG0626	cystathionine gamma-synthase activity
JO40_RS00410	COG1757	Na H antiporter
JO40_RS00445	COG1122	ATPase activity
JO40_RS00505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JO40_RS00525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JO40_RS00555	COG0598	Magnesium transport protein CorA
JO40_RS00560	COG0617	tRNA 3'-terminal CCA addition
JO40_RS00575	COG0071	Belongs to the small heat shock protein (HSP20) family
JO40_RS00585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JO40_RS00590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JO40_RS00600	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JO40_RS00620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JO40_RS00620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JO40_RS00630	COG1570	exodeoxyribonuclease VII activity
JO40_RS00635	COG1067	ATP-dependent peptidase activity
JO40_RS00645	COG2703	oxygen carrier activity
JO40_RS00650	COG2183	response to ionizing radiation
JO40_RS00660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JO40_RS00665	COG1722	exodeoxyribonuclease VII activity
JO40_RS00670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JO40_RS00710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JO40_RS00720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JO40_RS00725	COG0085	RNA polymerase activity
JO40_RS00730	COG0222	ribosome binding
JO40_RS00735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JO40_RS00740	COG0081	regulation of translation
JO40_RS00745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JO40_RS00750	COG0250	Participates in transcription elongation, termination and antitermination
JO40_RS00755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JO40_RS00765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JO40_RS00795	COG1652	LysM domain
JO40_RS00815	COG0326	Molecular chaperone. Has ATPase activity
JO40_RS00825	COG0210	DNA helicase
JO40_RS00830	COG1132	(ABC) transporter
JO40_RS00835	COG1132	(ABC) transporter
JO40_RS00840	COG2195	Cleaves the N-terminal amino acid of tripeptides
JO40_RS00860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JO40_RS00870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JO40_RS00875	COG0840	transmembrane signaling receptor activity
JO40_RS00895	COG3956	TIGRFAM MazG family protein
JO40_RS00900	COG0545	Peptidyl-prolyl cis-trans isomerase
JO40_RS00920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JO40_RS00945	COG1132	(ABC) transporter
JO40_RS00950	COG1012	belongs to the aldehyde dehydrogenase family
JO40_RS00955	COG0357	Ribosomal RNA small subunit methyltransferase G
JO40_RS00985	COG4115	mRNA cleavage
JO40_RS00995	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JO40_RS01015	COG1120	ATPase activity
JO40_RS01020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JO40_RS01025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JO40_RS01035	COG4865	methylaspartate mutase activity
JO40_RS01040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JO40_RS01050	COG0513	Belongs to the DEAD box helicase family
JO40_RS01055	COG0284	orotidine-5'-phosphate decarboxylase activity
JO40_RS01075	COG1131	(ABC) transporter
JO40_RS01080	COG2208	phosphoserine phosphatase activity
JO40_RS01080	COG2770	Histidine kinase
JO40_RS01105	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
JO40_RS01125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JO40_RS01140	COG1272	protein, Hemolysin III
JO40_RS01145	COG3177	Filamentation induced by cAMP protein fic
JO40_RS01150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JO40_RS01170	COG2378	regulation of single-species biofilm formation
JO40_RS01200	COG2885	chlorophyll binding
JO40_RS01205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JO40_RS01205	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JO40_RS01205	COG1013	pyruvate-flavodoxin oxidoreductase activity
JO40_RS01205	COG0674	pyruvate-flavodoxin oxidoreductase activity
JO40_RS01210	COG0737	Belongs to the 5'-nucleotidase family
JO40_RS01250	COG0148	phosphopyruvate hydratase activity
JO40_RS01255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JO40_RS01265	COG2738	Putative neutral zinc metallopeptidase
JO40_RS01280	COG2226	methyltransferase
JO40_RS01315	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JO40_RS01320	COG0671	phosphoesterase, PA-phosphatase related
JO40_RS01345	COG1022	Amp-dependent synthetase and ligase
JO40_RS01350	COG1475	DNA binding
JO40_RS01360	COG0739	heme binding
JO40_RS01365	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JO40_RS01365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JO40_RS01380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JO40_RS01385	COG0549	Belongs to the carbamate kinase family
JO40_RS01390	COG0534	Mate efflux family protein
JO40_RS01400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JO40_RS01410	COG1362	aminopeptidase activity
JO40_RS01415	COG0445	tRNA wobble uridine modification
JO40_RS01420	COG0210	DNA helicase
JO40_RS01440	COG3604	Transcriptional regulator
JO40_RS01490	COG1573	uracil-dna glycosylase
JO40_RS01495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JO40_RS01500	COG0196	riboflavin kinase activity
JO40_RS01505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JO40_RS01510	COG1185	polyribonucleotide nucleotidyltransferase activity
JO40_RS01515	COG0756	dUTP diphosphatase activity
JO40_RS01530	COG0564	pseudouridine synthase activity
JO40_RS01535	COG0156	8-amino-7-oxononanoate synthase activity
JO40_RS01565	COG1132	(ABC) transporter
JO40_RS01575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JO40_RS01580	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JO40_RS01585	COG1329	Transcriptional regulator
JO40_RS01590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JO40_RS01590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JO40_RS01595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JO40_RS01620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JO40_RS01625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JO40_RS01630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JO40_RS01660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JO40_RS01675	COG1111	helicase
JO40_RS01675	COG1205	dead DEAH box helicase
JO40_RS01690	COG0504	CTP synthase activity
JO40_RS01705	COG1747	RNA polymerase binding
JO40_RS01705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JO40_RS01720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JO40_RS01765	COG0330	HflC and HflK could
JO40_RS01785	COG1129	ABC transporter
JO40_RS01810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JO40_RS01820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JO40_RS01830	COG4608	Belongs to the ABC transporter superfamily
JO40_RS01835	COG0444	Belongs to the ABC transporter superfamily
JO40_RS01850	COG0601	transmembrane transport
JO40_RS01860	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JO40_RS01865	COG4657	Part of a membrane complex involved in electron transport
JO40_RS01870	COG4660	Part of a membrane complex involved in electron transport
JO40_RS01880	COG4658	electron transport chain
JO40_RS01885	COG4656	Part of a membrane complex involved in electron transport
JO40_RS01895	COG2304	oxidoreductase activity
JO40_RS01910	COG0574	Belongs to the PEP-utilizing enzyme family
JO40_RS01910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JO40_RS01920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JO40_RS01945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JO40_RS01960	COG2197	response regulator
JO40_RS01985	COG1187	pseudouridine synthase activity
JO40_RS01990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JO40_RS02040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JO40_RS02055	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
JO40_RS02060	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JO40_RS02070	COG2226	methyltransferase
JO40_RS02090	COG1254	Belongs to the acylphosphatase family
JO40_RS02115	COG0203	ribosomal protein L17
JO40_RS02120	COG0202	RNA polymerase activity
JO40_RS02125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JO40_RS02130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JO40_RS02140	COG0200	Binds to the 23S rRNA
JO40_RS02145	COG1841	ribosomal large subunit assembly
JO40_RS02150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JO40_RS02155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JO40_RS02160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JO40_RS02165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JO40_RS02170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JO40_RS02175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JO40_RS02180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JO40_RS02185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JO40_RS02190	COG0255	Belongs to the universal ribosomal protein uL29 family
JO40_RS02195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JO40_RS02200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JO40_RS02205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JO40_RS02210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JO40_RS02215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JO40_RS02220	COG0089	rRNA binding
JO40_RS02225	COG0088	Forms part of the polypeptide exit tunnel
JO40_RS02230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JO40_RS02235	COG0051	transcription antitermination factor activity, RNA binding
JO40_RS02240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JO40_RS02255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JO40_RS02285	COG0840	transmembrane signaling receptor activity
JO40_RS02290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JO40_RS02295	COG0564	pseudouridine synthase activity
JO40_RS02305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JO40_RS02310	COG0166	Belongs to the GPI family
JO40_RS02315	COG1362	aminopeptidase activity
JO40_RS02320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JO40_RS02325	COG0724	RNA recognition motif
JO40_RS02330	COG2211	Major facilitator Superfamily
JO40_RS02380	COG0396	ATPase activity
JO40_RS02385	COG0719	Fe-S assembly protein
JO40_RS02395	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
JO40_RS02415	COG2201	protein-glutamate methylesterase activity
JO40_RS02435	COG1137	ATPase activity
JO40_RS02440	COG0193	aminoacyl-tRNA hydrolase activity
JO40_RS02450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JO40_RS02460	COG0601	transmembrane transport
JO40_RS02465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JO40_RS02470	COG0444	Belongs to the ABC transporter superfamily
JO40_RS02475	COG4608	Belongs to the ABC transporter superfamily
JO40_RS02480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JO40_RS02485	COG1876	peptidase activity
JO40_RS02505	COG0484	heat shock protein binding
JO40_RS02510	COG0443	Heat shock 70 kDa protein
JO40_RS02515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JO40_RS02545	COG1120	ATPase activity
JO40_RS02575	COG0534	Mate efflux family protein
JO40_RS02600	COG1192	Involved in chromosome partitioning
JO40_RS02625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JO40_RS02630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JO40_RS02645	COG1028	Short-chain dehydrogenase reductase Sdr
JO40_RS02660	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JO40_RS02685	COG0439	Biotin carboxylase
JO40_RS02690	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JO40_RS02695	COG0825	malonyl-CoA metabolic process
JO40_RS02700	COG2986	histidine ammonia-lyase
JO40_RS02715	COG0714	Associated with various cellular activities
JO40_RS02750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JO40_RS02755	COG0154	amidase activity
JO40_RS02760	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JO40_RS02900	COG1136	(ABC) transporter
JO40_RS03020	COG1396	sequence-specific DNA binding
JO40_RS03030	COG3550	peptidyl-serine autophosphorylation
JO40_RS03060	COG2249	NAD(P)H dehydrogenase (quinone) activity
JO40_RS03075	COG1132	(ABC) transporter
JO40_RS03080	COG1132	(ABC) transporter
JO40_RS03080	COG2375	cellular response to nickel ion
JO40_RS03130	COG1132	(ABC) transporter
JO40_RS03135	COG1132	(ABC) transporter
JO40_RS03140	COG0280	phosphate acetyltransferase
JO40_RS03145	COG0457	Tetratricopeptide repeat
JO40_RS03150	COG0587	DNA-directed DNA polymerase activity
JO40_RS03185	COG3177	Filamentation induced by cAMP protein fic
JO40_RS03195	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JO40_RS03195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JO40_RS03200	COG0446	pyridine nucleotide-disulphide oxidoreductase
JO40_RS03225	COG1136	(ABC) transporter
JO40_RS03235	COG0095	Lipoate-protein ligase
JO40_RS03245	COG1131	(ABC) transporter
JO40_RS03250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JO40_RS03255	COG1122	ATPase activity
JO40_RS03300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JO40_RS03310	COG0516	GMP reductase activity
JO40_RS03315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JO40_RS03320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JO40_RS03350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JO40_RS03390	COG1774	PSP1 C-terminal conserved region
JO40_RS03395	COG1728	Protein conserved in bacteria
JO40_RS03405	COG0739	heme binding
JO40_RS03420	COG0366	Alpha amylase catalytic
JO40_RS03430	COG1609	Transcriptional regulator
JO40_RS03465	COG0543	2 iron, 2 sulfur cluster binding
JO40_RS03470	COG0784	Response regulator, receiver
JO40_RS03470	COG3437	response regulator, receiver
JO40_RS03490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JO40_RS03515	COG1222	aaa ATPase
JO40_RS03535	COG3177	Filamentation induced by cAMP protein fic
JO40_RS03550	COG1129	ABC transporter
JO40_RS03555	COG1132	(ABC) transporter
JO40_RS03590	COG1132	(ABC) transporter
JO40_RS03595	COG1309	transcriptional regulator
JO40_RS03600	COG3189	MarR family transcriptional regulator
JO40_RS03615	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JO40_RS03625	COG1684	flagellar biosynthetic protein fliR
JO40_RS03630	COG1987	bacterial-type flagellum assembly
JO40_RS03655	COG1228	amidohydrolase
JO40_RS03685	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
JO40_RS03690	COG0583	DNA-binding transcription factor activity
JO40_RS03700	COG0747	negative chemotaxis
JO40_RS03705	COG4608	Belongs to the ABC transporter superfamily
JO40_RS03710	COG0444	Belongs to the ABC transporter superfamily
JO40_RS03715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JO40_RS03735	COG0523	cobalamin synthesis protein
JO40_RS03740	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
JO40_RS03755	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
JO40_RS03770	COG1840	ABC-type Fe3 transport system, periplasmic component
JO40_RS03780	COG4143	(ABC) transporter
JO40_RS03800	COG1473	amidohydrolase
JO40_RS03805	COG4585	Histidine kinase
JO40_RS03810	COG2197	response regulator
JO40_RS03815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JO40_RS03890	COG3093	addiction module antidote protein HigA
JO40_RS03895	COG3549	Plasmid maintenance system killer
JO40_RS03905	COG0728	peptidoglycan biosynthetic process
JO40_RS03910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JO40_RS03915	COG3588	fructose-bisphosphate aldolase
JO40_RS03940	COG0012	GTP binding
JO40_RS03945	COG0616	signal peptide processing
JO40_RS03950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JO40_RS03970	COG5012	cobalamin binding
JO40_RS03975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JO40_RS03980	COG1132	(ABC) transporter
JO40_RS03985	COG1132	(ABC) transporter
JO40_RS03995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JO40_RS04000	COG0363	glucosamine-6-phosphate deaminase activity
JO40_RS04005	COG0628	permease
JO40_RS04010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JO40_RS04015	COG0534	Mate efflux family protein
JO40_RS04025	COG0786	glutamate:sodium symporter activity
JO40_RS04030	COG0840	transmembrane signaling receptor activity
JO40_RS04035	COG0840	transmembrane signaling receptor activity
JO40_RS04040	COG0813	purine-nucleoside phosphorylase activity
JO40_RS04085	COG5001	Diguanylate cyclase
JO40_RS04085	COG5002	protein histidine kinase activity
JO40_RS04090	COG0540	Belongs to the ATCase OTCase family
JO40_RS04090	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JO40_RS04120	COG3842	ATPase activity
JO40_RS04125	COG3833	ABC-type maltose transport systems, permease component
JO40_RS04130	COG1175	transmembrane transport
JO40_RS04140	COG1418	mRNA catabolic process
JO40_RS04150	COG0420	3'-5' exonuclease activity
JO40_RS04155	COG3290	protein histidine kinase activity
JO40_RS04155	COG0840	transmembrane signaling receptor activity
JO40_RS04165	COG1131	(ABC) transporter
JO40_RS04185	COG0716	FMN binding
JO40_RS04200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JO40_RS04205	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JO40_RS04210	COG0592	DNA-directed DNA polymerase activity
JO40_RS04215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JO40_RS04285	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
JO40_RS04330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JO40_RS04340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JO40_RS04345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JO40_RS04375	COG2184	nucleotidyltransferase activity
JO40_RS04385	COG0730	response to heat
JO40_RS04405	COG4208	sulfate ABC transporter
JO40_RS04410	COG3839	Belongs to the ABC transporter superfamily
JO40_RS04430	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JO40_RS04440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JO40_RS04460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JO40_RS04465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JO40_RS04475	COG0569	domain protein
JO40_RS04480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JO40_RS04500	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JO40_RS04520	COG2235	arginine
JO40_RS04525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JO40_RS04540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JO40_RS04545	COG0569	domain protein
JO40_RS04555	COG1487	ribonuclease activity
JO40_RS04570	COG0714	Associated with various cellular activities
JO40_RS04575	COG4536	flavin adenine dinucleotide binding
JO40_RS04580	COG4536	flavin adenine dinucleotide binding
JO40_RS04595	COG0514	ATP-dependent DNA helicase (RecQ)
JO40_RS04605	COG1518	maintenance of DNA repeat elements
JO40_RS04610	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
JO40_RS04625	COG1132	(ABC) transporter
JO40_RS04640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JO40_RS04660	COG2274	protein secretion by the type I secretion system
JO40_RS04660	COG3271	cysteine-type peptidase activity
JO40_RS04670	COG0438	transferase activity, transferring glycosyl groups
JO40_RS04675	COG3842	ATPase activity
JO40_RS04685	COG3706	GGDEF domain
JO40_RS04695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JO40_RS04700	COG0215	cysteine-tRNA ligase activity
JO40_RS04715	COG1305	Transglutaminase-like
JO40_RS04720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JO40_RS04725	COG0569	domain protein
JO40_RS04730	COG2887	Belongs to the helicase family. UvrD subfamily
JO40_RS04780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JO40_RS04830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JO40_RS04840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JO40_RS04850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JO40_RS04860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JO40_RS04870	COG4555	ABC transporter
JO40_RS04930	COG1151	hydroxylamine reductase activity
JO40_RS04950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JO40_RS04955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JO40_RS04985	COG0823	Involved in the tonB-independent uptake of proteins
JO40_RS04985	COG1506	peptidase
JO40_RS04985	COG4946	Tricorn protease homolog
JO40_RS05000	COG1104	cysteine desulfurase activity
JO40_RS05005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JO40_RS05010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JO40_RS05030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JO40_RS05045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JO40_RS05055	COG1929	Belongs to the glycerate kinase type-1 family
JO40_RS05060	COG2217	Heavy metal translocating P-type atpase
JO40_RS05070	COG0494	nUDIX hydrolase
JO40_RS05075	COG0783	Belongs to the Dps family
JO40_RS05080	COG0450	alkyl hydroperoxide reductase
JO40_RS05085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JO40_RS05100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JO40_RS05105	COG1363	Peptidase, m42
JO40_RS05120	COG0423	glycine-tRNA ligase activity
JO40_RS05140	COG1472	Belongs to the glycosyl hydrolase 3 family
JO40_RS05250	COG1129	ABC transporter
JO40_RS05265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JO40_RS05300	COG1011	Hydrolase
JO40_RS05320	COG1132	(ABC) transporter
JO40_RS05320	COG2375	cellular response to nickel ion
JO40_RS05350	COG0456	acetyltransferase
JO40_RS05385	COG1129	ABC transporter
JO40_RS05455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JO40_RS05490	COG1191	sigma factor activity
JO40_RS05505	COG1419	protein localization to endoplasmic reticulum
JO40_RS05510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JO40_RS05540	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JO40_RS05555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JO40_RS05560	COG1360	Flagellar Motor Protein
JO40_RS05565	COG1580	Controls the rotational direction of flagella during chemotaxis
JO40_RS05570	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JO40_RS05575	COG1776	CheC inhibitor of MCP methylation
JO40_RS05575	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JO40_RS05585	COG1338	Plays a role in the flagellum-specific transport system
JO40_RS05625	COG2423	ornithine cyclodeaminase activity
JO40_RS05630	COG1196	nuclear chromosome segregation
JO40_RS05630	COG0741	lytic transglycosylase activity
JO40_RS05630	COG0739	heme binding
JO40_RS05635	COG4545	Glutaredoxin-related protein
JO40_RS05650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JO40_RS05665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JO40_RS05665	COG3116	cell division
JO40_RS05670	COG0084	hydrolase, TatD family'
JO40_RS05680	COG2199	diguanylate cyclase activity
JO40_RS05680	COG2203	Gaf domain
JO40_RS05705	COG0187	DNA topoisomerase II activity
JO40_RS05710	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JO40_RS05715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JO40_RS05760	COG1136	(ABC) transporter
JO40_RS05760	COG0577	efflux transmembrane transporter activity
JO40_RS05765	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JO40_RS05820	COG1266	CAAX protease self-immunity
JO40_RS05830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JO40_RS05890	COG1012	belongs to the aldehyde dehydrogenase family
JO40_RS05900	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
JO40_RS05925	COG1113	amino acid transport
JO40_RS05930	COG0196	riboflavin kinase activity
JO40_RS05935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JO40_RS05955	COG0840	transmembrane signaling receptor activity
JO40_RS05960	COG0826	peptidase U32
JO40_RS05970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JO40_RS05975	COG1509	lysine 2,3-aminomutase activity
JO40_RS05980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JO40_RS05985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JO40_RS06000	COG0205	6-phosphofructokinase activity
JO40_RS06030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JO40_RS06050	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
JO40_RS06145	COG1592	Rubrerythrin
JO40_RS06150	COG0514	ATP-dependent DNA helicase (RecQ)
JO40_RS06155	COG1381	Involved in DNA repair and RecF pathway recombination
JO40_RS06165	COG0343	queuine tRNA-ribosyltransferase activity
JO40_RS06210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JO40_RS06220	COG4555	ABC transporter
JO40_RS06235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JO40_RS06240	COG2239	Acts as a magnesium transporter
JO40_RS06250	COG0546	phosphoglycolate phosphatase activity
JO40_RS06260	COG3118	belongs to the thioredoxin family
JO40_RS06275	COG1120	ATPase activity
JO40_RS06280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JO40_RS06295	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
JO40_RS06295	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
JO40_RS06300	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
JO40_RS06325	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JO40_RS06330	COG1757	Na H antiporter
JO40_RS06335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JO40_RS06340	COG4443	Transcriptional Coactivator p15 (PC4)
JO40_RS06350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JO40_RS06355	COG0301	tRNA thio-modification
JO40_RS06380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JO40_RS06385	COG1121	(ABC) transporter
JO40_RS06395	COG4988	ABC transporter
JO40_RS06400	COG1132	(ABC) transporter
JO40_RS06430	COG0335	large ribosomal subunit rRNA binding
JO40_RS06435	COG0336	Belongs to the RNA methyltransferase TrmD family
JO40_RS06440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JO40_RS06445	COG1837	Belongs to the UPF0109 family
JO40_RS06450	COG0228	four-way junction DNA binding
JO40_RS06470	COG0577	efflux transmembrane transporter activity
JO40_RS06470	COG1136	(ABC) transporter
JO40_RS06475	COG1136	(ABC) transporter
JO40_RS06490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JO40_RS06495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JO40_RS06540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JO40_RS06545	COG1285	pathogenesis
JO40_RS06565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JO40_RS06570	COG0534	Mate efflux family protein
JO40_RS06575	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
JO40_RS06580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JO40_RS06585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JO40_RS06600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JO40_RS06605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JO40_RS06610	COG0116	Belongs to the methyltransferase superfamily
JO40_RS06615	COG3735	TraB family
JO40_RS06625	COG0791	NLP P60 protein
JO40_RS06630	COG0318	PFAM AMP-dependent synthetase and ligase
JO40_RS06640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JO40_RS06685	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JO40_RS06700	COG4974	Belongs to the 'phage' integrase family
JO40_RS06705	COG0732	type I restriction modification DNA specificity domain
JO40_RS06720	COG1979	alcohol dehydrogenase
JO40_RS06765	COG0583	DNA-binding transcription factor activity
JO40_RS06770	COG0656	L-ascorbic acid biosynthetic process
JO40_RS06815	COG3620	sequence-specific DNA binding
JO40_RS06820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JO40_RS06825	COG3421	Type III restriction
JO40_RS06830	COG2249	NAD(P)H dehydrogenase (quinone) activity
JO40_RS06845	COG0698	ribose 5-phosphate isomerase
JO40_RS06850	COG0039	L-malate dehydrogenase activity
JO40_RS06855	COG0534	Mate efflux family protein
JO40_RS06860	COG3848	Pyruvate phosphate dikinase
JO40_RS06860	COG0574	Belongs to the PEP-utilizing enzyme family
JO40_RS06865	COG1309	transcriptional regulator
JO40_RS06880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JO40_RS06900	COG1477	protein flavinylation
JO40_RS06905	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JO40_RS06910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JO40_RS06925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JO40_RS06945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JO40_RS06950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JO40_RS06955	COG1862	Preprotein translocase
JO40_RS06960	COG0629	single-stranded DNA binding
JO40_RS06970	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JO40_RS06975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JO40_RS06990	COG0482	sulfurtransferase activity
JO40_RS07000	COG0351	phosphomethylpyrimidine kinase
JO40_RS07010	COG1131	(ABC) transporter
JO40_RS07030	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JO40_RS07045	COG0406	alpha-ribazole phosphatase activity
JO40_RS07050	COG0322	excinuclease ABC activity
JO40_RS07060	COG1921	L-seryl-tRNASec selenium transferase activity
JO40_RS07080	COG1136	(ABC) transporter
JO40_RS07080	COG0577	efflux transmembrane transporter activity
JO40_RS07085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JO40_RS07105	COG1639	'signal transduction protein
JO40_RS07110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JO40_RS07120	COG0101	tRNA pseudouridine synthase activity
JO40_RS07135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JO40_RS07140	COG0840	transmembrane signaling receptor activity
JO40_RS07190	COG1132	(ABC) transporter
JO40_RS07200	COG0826	peptidase U32
JO40_RS07205	COG3142	Participates in the control of copper homeostasis
JO40_RS07255	COG3876	Protein conserved in bacteria
JO40_RS07275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JO40_RS07280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JO40_RS07285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JO40_RS07290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JO40_RS07295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JO40_RS07300	COG0484	heat shock protein binding
JO40_RS07305	COG0528	UMP kinase activity
JO40_RS07310	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JO40_RS07325	COG0539	negative regulation of cytoplasmic translation
JO40_RS07330	COG2204	response regulator
JO40_RS07335	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JO40_RS07355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JO40_RS07380	COG0251	oxidation-reduction process
JO40_RS07410	COG1131	(ABC) transporter
JO40_RS07425	COG4585	Histidine kinase
JO40_RS07430	COG0542	response to heat
JO40_RS07450	COG2949	membrane
JO40_RS07460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JO40_RS07475	COG1692	metallophosphoesterase
JO40_RS07485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JO40_RS07495	COG0484	heat shock protein binding
JO40_RS07505	COG5341	Protein conserved in bacteria
JO40_RS07510	COG1752	Esterase of the alpha-beta hydrolase superfamily
JO40_RS07515	COG0584	glycerophosphoryl diester phosphodiesterase
JO40_RS07520	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JO40_RS07525	COG1704	LemA family
JO40_RS07530	COG0018	arginyl-trna synthetase
JO40_RS07535	COG1040	competence protein
JO40_RS07540	COG2003	Belongs to the UPF0758 family
JO40_RS07545	COG1686	Belongs to the peptidase S11 family
JO40_RS07560	COG2116	formate transmembrane transporter activity
JO40_RS07565	COG2084	Dehydrogenase
JO40_RS07570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JO40_RS07585	COG4786	Flagellar basal body rod
JO40_RS07595	COG3951	Flagellar rod assembly protein muramidase FlgJ
JO40_RS07600	COG1690	Belongs to the RtcB family
JO40_RS07665	COG1132	(ABC) transporter
JO40_RS07695	COG1132	(ABC) transporter
JO40_RS07700	COG1129	ABC transporter
JO40_RS07735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JO40_RS07750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JO40_RS07775	COG2604	Protein of unknown function DUF115
JO40_RS07795	COG2195	Cleaves the N-terminal amino acid of tripeptides
JO40_RS07805	COG0803	Belongs to the bacterial solute-binding protein 9 family
JO40_RS07825	COG0442	prolyl-tRNA aminoacylation
JO40_RS07840	COG1879	ABC-type sugar transport system periplasmic component
JO40_RS07865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JO40_RS07870	COG0666	response to abiotic stimulus
JO40_RS07875	COG2078	PFAM AMMECR1 domain protein
JO40_RS07875	COG3885	ferrous iron binding
JO40_RS07890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JO40_RS07895	COG0281	malic enzyme
JO40_RS07915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JO40_RS07920	COG0444	Belongs to the ABC transporter superfamily
JO40_RS07925	COG4608	Belongs to the ABC transporter superfamily
JO40_RS07930	COG0426	domain, Protein
JO40_RS07930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JO40_RS07940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JO40_RS07945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JO40_RS07960	COG0564	pseudouridine synthase activity
JO40_RS07975	COG1561	YicC-like family, N-terminal region
JO40_RS07980	COG1102	Psort location Cytoplasmic, score
JO40_RS07985	COG3706	GGDEF domain
JO40_RS07995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JO40_RS08025	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JO40_RS08045	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JO40_RS08055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JO40_RS08075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JO40_RS08130	COG2376	Dihydroxyacetone kinase
JO40_RS08135	COG2376	Dihydroxyacetone kinase
JO40_RS08145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JO40_RS08170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JO40_RS08175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JO40_RS08180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JO40_RS08190	COG0779	Required for maturation of 30S ribosomal subunits
JO40_RS08210	COG0563	adenylate kinase activity
JO40_RS08215	COG3033	Beta-eliminating lyase
JO40_RS08235	COG1366	Belongs to the anti-sigma-factor antagonist family
JO40_RS08275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JO40_RS08280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JO40_RS08300	COG0459	protein refolding
JO40_RS08320	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JO40_RS08325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JO40_RS08340	COG0736	holo-[acyl-carrier-protein] synthase activity
JO40_RS08345	COG3681	Belongs to the UPF0597 family
JO40_RS08350	COG4953	penicillin-binding protein 1C
JO40_RS08360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JO40_RS08365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JO40_RS08375	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JO40_RS08380	COG1671	Belongs to the UPF0178 family
JO40_RS08390	COG0741	lytic transglycosylase activity
JO40_RS08390	COG1388	LysM domain
JO40_RS08465	COG0058	SHG alpha-glucan phosphorylase activity
JO40_RS08475	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JO40_RS08495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JO40_RS08530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JO40_RS08540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JO40_RS08545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JO40_RS08550	COG4750	Nucleotidyl transferase
JO40_RS08555	COG1115	amino acid carrier protein
JO40_RS08575	COG1193	negative regulation of DNA recombination
JO40_RS08625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JO40_RS08635	COG1702	phosphate starvation-inducible protein PhoH
JO40_RS08650	COG0149	triose-phosphate isomerase activity
JO40_RS08655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JO40_RS08675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JO40_RS08695	COG2885	chlorophyll binding
JO40_RS08705	COG1199	ATP-dependent helicase activity
JO40_RS08725	COG0823	Involved in the tonB-independent uptake of proteins
JO40_RS08740	COG4254	PFAM FecR protein
JO40_RS08775	COG1286	toxin biosynthetic process
JO40_RS08780	COG0470	DNA polymerase III
JO40_RS08790	COG2204	response regulator
JO40_RS08795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JO40_RS08810	COG0475	glutathione-regulated potassium exporter activity
JO40_RS08815	COG1283	sodium-dependent phosphate transmembrane transporter activity
JO40_RS08860	COG0456	acetyltransferase
JO40_RS08870	COG0535	radical SAM domain protein
JO40_RS08880	COG1733	regulation of RNA biosynthetic process
JO40_RS08895	COG1234	tRNA 3'-trailer cleavage
JO40_RS08900	COG2378	regulation of single-species biofilm formation
JO40_RS08915	COG4555	ABC transporter
JO40_RS08925	COG2207	Transcriptional regulator
JO40_RS08930	COG1132	(ABC) transporter
JO40_RS08930	COG2375	cellular response to nickel ion
JO40_RS08955	COG1129	ABC transporter
JO40_RS09000	COG0556	nucleotide-excision repair
JO40_RS09005	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JO40_RS09005	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JO40_RS09010	COG0557	exoribonuclease II activity
JO40_RS09035	COG4115	mRNA cleavage
JO40_RS09040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JO40_RS09075	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
JO40_RS09080	COG0640	Transcriptional regulator
JO40_RS09085	COG2217	Heavy metal translocating P-type atpase
JO40_RS09095	COG0564	pseudouridine synthase activity
JO40_RS09110	COG4656	Part of a membrane complex involved in electron transport
JO40_RS09155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JO40_RS09160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JO40_RS09160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JO40_RS09175	COG0488	(ABC) transporter
JO40_RS09185	COG0047	phosphoribosylformylglycinamidine synthase activity
JO40_RS09195	COG1078	dGTPase activity
JO40_RS09220	COG0475	glutathione-regulated potassium exporter activity
JO40_RS09245	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
JO40_RS09245	COG0028	Belongs to the TPP enzyme family
JO40_RS09250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JO40_RS09290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JO40_RS09305	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JO40_RS09310	COG1216	Glycosyl transferase, family 2
JO40_RS09330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JO40_RS09350	COG1215	transferase activity, transferring glycosyl groups
JO40_RS09355	COG1215	transferase activity, transferring glycosyl groups
JO40_RS09370	COG0463	Glycosyl transferase, family 2
JO40_RS09370	COG1216	Glycosyl transferase, family 2
JO40_RS09410	COG3306	glycosyltransferase involved in LPS biosynthesis
JO40_RS09435	COG0706	membrane insertase activity
JO40_RS09465	COG0706	membrane insertase activity
JO40_RS09475	COG0297	glycogen (starch) synthase activity
JO40_RS09480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JO40_RS09495	COG0124	histidyl-tRNA synthetase
JO40_RS09505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JO40_RS09515	COG0488	(ABC) transporter
JO40_RS09525	COG0793	Belongs to the peptidase S41A family
JO40_RS09585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JO40_RS09590	COG0632	four-way junction helicase activity
JO40_RS09660	COG1136	(ABC) transporter
JO40_RS09665	COG0577	efflux transmembrane transporter activity
JO40_RS09665	COG1136	(ABC) transporter
JO40_RS09695	COG2361	Protein of unknown function DUF86
JO40_RS09770	COG0561	phosphatase activity
JO40_RS09800	COG2361	Protein of unknown function DUF86
JO40_RS09810	COG2337	Toxic component of a toxin-antitoxin (TA) module
JO40_RS09830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JO40_RS09835	COG2878	Part of a membrane complex involved in electron transport
JO40_RS09840	COG0481	GTPase activity
JO40_RS09880	COG1114	Component of the transport system for branched-chain amino acids
JO40_RS09895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JO40_RS09925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JO40_RS09935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JO40_RS09940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JO40_RS09955	COG0799	negative regulation of ribosome biogenesis
JO40_RS09960	COG2059	Chromate
JO40_RS09970	COG0484	heat shock protein binding
JO40_RS09980	COG0708	Exodeoxyribonuclease III
JO40_RS09990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JO40_RS10000	COG0739	heme binding
JO40_RS10065	COG0617	tRNA 3'-terminal CCA addition
JO40_RS10095	COG1846	Transcriptional regulator
JO40_RS10100	COG0519	Catalyzes the synthesis of GMP from XMP
JO40_RS10115	COG0126	phosphoglycerate kinase activity
JO40_RS10120	COG0860	N-Acetylmuramoyl-L-alanine amidase
JO40_RS10140	COG0268	Binds directly to 16S ribosomal RNA
JO40_RS10160	COG1058	Belongs to the CinA family
JO40_RS10160	COG1546	Belongs to the CinA family
JO40_RS10190	COG0588	phosphoglycerate mutase activity
JO40_RS10220	COG1131	(ABC) transporter
JO40_RS10230	COG0457	Tetratricopeptide repeat
JO40_RS10235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JO40_RS10240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JO40_RS10245	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
JO40_RS10250	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
JO40_RS10255	COG1394	ATPase activity, coupled to movement of substances
JO40_RS10260	COG1269	ATP hydrolysis coupled proton transport
JO40_RS10270	COG0360	Binds together with S18 to 16S ribosomal RNA
JO40_RS10275	COG0629	single-stranded DNA binding
JO40_RS10280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JO40_RS10285	COG0359	binds to the 23S rRNA
JO40_RS10295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JO40_RS10300	COG0740	serine-type endopeptidase activity
JO40_RS10305	COG0544	peptidyl-prolyl cis-trans isomerase activity
JO40_RS10325	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JO40_RS10335	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JO40_RS10350	COG2885	chlorophyll binding
JO40_RS10355	COG0305	Participates in initiation and elongation during chromosome replication
JO40_RS10365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JO40_RS10370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JO40_RS10375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JO40_RS10405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JO40_RS10410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JO40_RS10415	COG2033	superoxide reductase activity
JO40_RS10455	COG0497	DNA recombination
JO40_RS10475	COG0791	NLP P60 protein
JO40_RS10475	COG1388	LysM domain
JO40_RS10485	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JO40_RS10490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JO40_RS10500	COG0312	modulator of DNA gyrase
JO40_RS10515	COG1692	metallophosphoesterase
JO40_RS10525	COG0142	geranyltranstransferase activity
JO40_RS10550	COG0727	PFAM Uncharacterised protein family (UPF0153)
JO40_RS10565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JO40_RS10585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JO40_RS10600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JO40_RS10605	COG2721	sulfolactate sulfo-lyase activity
JO40_RS10615	COG1349	DNA-binding transcription factor activity
JO40_RS10620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JO40_RS10645	COG1047	Peptidyl-prolyl cis-trans
JO40_RS10660	COG0731	radical SAM domain protein
JO40_RS10675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JO40_RS10680	COG1979	alcohol dehydrogenase
JO40_RS10685	COG2255	four-way junction helicase activity
JO40_RS10690	COG1725	Transcriptional regulator
JO40_RS10695	COG0653	protein targeting
JO40_RS10700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JO40_RS10705	COG0138	bifunctional purine biosynthesis protein purh
JO40_RS10710	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JO40_RS10715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JO40_RS10720	COG0205	6-phosphofructokinase activity
JO40_RS10725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JO40_RS10760	COG0297	glycogen (starch) synthase activity
JO40_RS10785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JO40_RS10795	COG0835	chemotaxis
JO40_RS10805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JO40_RS10810	COG0488	(ABC) transporter
JO40_RS10820	COG0493	'glutamate synthase
JO40_RS10820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JO40_RS10825	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
JO40_RS10865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JO40_RS10885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JO40_RS10895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JO40_RS10900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JO40_RS10905	COG0509	glycine decarboxylation via glycine cleavage system
JO40_RS10910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JO40_RS10920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JO40_RS10950	COG3052	prosthetic group binding
JO40_RS10955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JO40_RS10955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JO40_RS10955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JO40_RS10960	COG0237	dephospho-CoA kinase activity
JO40_RS10970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JO40_RS10975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JO40_RS10990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JO40_RS11005	COG1122	ATPase activity
JO40_RS11010	COG1268	BioY protein
JO40_RS11105	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
JO40_RS11135	COG1136	(ABC) transporter
JO40_RS11140	COG0577	efflux transmembrane transporter activity
JO40_RS11160	COG3470	protein probably involved in high-affinity Fe2 transport
JO40_RS11165	COG0672	)-iron permease
JO40_RS11170	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JO40_RS11175	COG1136	(ABC) transporter
JO40_RS11185	COG1760	l-serine dehydratase
JO40_RS11190	COG1760	l-serine dehydratase
JO40_RS11200	COG0254	rRNA binding
JO40_RS11205	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JO40_RS11220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JO40_RS11220	COG0574	Belongs to the PEP-utilizing enzyme family
JO40_RS11230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JO40_RS11250	COG1196	nuclear chromosome segregation
JO40_RS11260	COG2201	protein-glutamate methylesterase activity
JO40_RS11270	COG0835	chemotaxis
JO40_RS11275	COG0643	Histidine kinase
JO40_RS11275	COG2198	Histidine kinase
JO40_RS11290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JO40_RS11295	COG0217	transcriptional regulatory protein
JO40_RS11345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JO40_RS11350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JO40_RS11360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JO40_RS11360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JO40_RS11375	COG0802	atpase or kinase
JO40_RS11385	COG2770	Histidine kinase
JO40_RS11385	COG3437	response regulator, receiver
JO40_RS11390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JO40_RS11430	COG0330	HflC and HflK could
JO40_RS11440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JO40_RS11470	COG1739	Uncharacterized protein family UPF0029
JO40_RS11500	COG0768	penicillin binding
JO40_RS11510	COG0433	COG0433 Predicted ATPase
JO40_RS11525	COG0009	L-threonylcarbamoyladenylate synthase
JO40_RS11570	COG2190	(PTS) system
JO40_RS11570	COG2211	Major facilitator Superfamily
JO40_RS11590	COG1162	GTPase activity
JO40_RS11600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JO40_RS11615	COG4166	transmembrane transport
JO40_RS11630	COG0525	valine-tRNA ligase activity
JO40_RS11635	COG2252	PERMEase
JO40_RS11660	COG0772	Belongs to the SEDS family
JO40_RS11665	COG0768	penicillin binding
JO40_RS11680	COG1077	Cell shape determining protein MreB Mrl
JO40_RS11695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JO40_RS11700	COG0358	DNA primase activity
JO40_RS11705	COG0606	chelatase, subunit chli
JO40_RS11720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JO40_RS11725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JO40_RS11735	COG1164	Oligoendopeptidase f
JO40_RS11780	COG1132	(ABC) transporter
JO40_RS11780	COG2375	cellular response to nickel ion
JO40_RS11790	COG1132	(ABC) transporter
JO40_RS12130	COG2885	chlorophyll binding
JO40_RS12135	COG0084	hydrolase, TatD family'
JO40_RS12145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JO40_RS12155	COG0438	transferase activity, transferring glycosyl groups
JO40_RS12160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JO40_RS12170	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JO40_RS12175	COG3880	PFAM UvrB UvrC protein
JO40_RS12185	COG1136	(ABC) transporter
JO40_RS12190	COG4591	ABC-type transport system involved in lipoprotein release permease component
JO40_RS12200	COG0552	protein localization to endoplasmic reticulum
JO40_RS12215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JO40_RS12250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JO40_RS12255	COG4475	Protein of unknown function (DUF436)
JO40_RS12290	COG0444	Belongs to the ABC transporter superfamily
JO40_RS12295	COG4608	Belongs to the ABC transporter superfamily
JO40_RS12320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JO40_RS12330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JO40_RS12335	COG3118	belongs to the thioredoxin family
JO40_RS12340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JO40_RS12345	COG0457	Tetratricopeptide repeat
JO40_RS12350	COG0037	tRNA processing
JO40_RS12355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JO40_RS12365	COG2088	sporulation resulting in formation of a cellular spore
JO40_RS12370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JO40_RS12460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JO40_RS12490	COG1079	Belongs to the binding-protein-dependent transport system permease family
JO40_RS12495	COG4603	Belongs to the binding-protein-dependent transport system permease family
JO40_RS12500	COG3845	ABC transporter
JO40_RS12505	COG1744	ABC transporter substrate-binding protein PnrA-like
JO40_RS12510	COG1363	Peptidase, m42
JO40_RS12515	COG1181	Belongs to the D-alanine--D-alanine ligase family
JO40_RS12530	COG0740	serine-type endopeptidase activity
JO40_RS12545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JO40_RS12555	COG1847	R3H domain protein
JO40_RS12560	COG0706	membrane insertase activity
JO40_RS12565	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JO40_RS12570	COG0594	ribonuclease P activity
JO40_RS12575	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JO40_RS12585	COG0803	Belongs to the bacterial solute-binding protein 9 family
JO40_RS12590	COG1121	(ABC) transporter
JO40_RS12595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JO40_RS12610	COG1472	Belongs to the glycosyl hydrolase 3 family
JO40_RS12625	COG1157	protein secretion by the type III secretion system
JO40_RS12630	COG1317	bacterial-type flagellum organization
JO40_RS12640	COG1766	The M ring may be actively involved in energy transduction
JO40_RS12645	COG1677	Flagellar hook-basal body complex protein FliE
JO40_RS12660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JO40_RS12665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JO40_RS12670	COG4974	Belongs to the 'phage' integrase family
JO40_RS12675	COG0551	DNA topoisomerase type I activity
JO40_RS12675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JO40_RS12680	COG0758	DNA mediated transformation
JO40_RS12695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JO40_RS12710	COG0772	Belongs to the SEDS family
JO40_RS12715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JO40_RS12725	COG0275	rRNA processing
JO40_RS12730	COG2001	Belongs to the MraZ family
JO40_RS12735	COG1505	serine-type exopeptidase activity
JO40_RS12770	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JO40_RS12805	COG1132	(ABC) transporter
JO40_RS12820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JO40_RS12855	COG1401	restriction endodeoxyribonuclease activity
JO40_RS12880	COG5492	domain, Protein