locus-tag	class	description
E4N74_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N74_RS00010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N74_RS00050	COG0577	efflux transmembrane transporter activity
E4N74_RS00050	COG1136	(ABC) transporter
E4N74_RS00055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N74_RS00080	COG1132	(ABC) transporter
E4N74_RS00140	COG1266	CAAX protease self-immunity
E4N74_RS00150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N74_RS00205	COG1012	belongs to the aldehyde dehydrogenase family
E4N74_RS00235	COG0531	amino acid
E4N74_RS00240	COG0196	riboflavin kinase activity
E4N74_RS00245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N74_RS00265	COG0840	transmembrane signaling receptor activity
E4N74_RS00270	COG0826	peptidase U32
E4N74_RS00280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N74_RS00285	COG1509	lysine 2,3-aminomutase activity
E4N74_RS00290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N74_RS00295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N74_RS00310	COG0205	6-phosphofructokinase activity
E4N74_RS00335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4N74_RS00340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N74_RS00360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N74_RS00410	COG2823	Periplasmic or secreted lipoprotein
E4N74_RS00410	COG1652	LysM domain
E4N74_RS00420	COG1592	Rubrerythrin
E4N74_RS00425	COG0514	ATP-dependent DNA helicase (RecQ)
E4N74_RS00430	COG1381	Involved in DNA repair and RecF pathway recombination
E4N74_RS00440	COG0343	queuine tRNA-ribosyltransferase activity
E4N74_RS00495	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4N74_RS00510	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N74_RS00520	COG4555	ABC transporter
E4N74_RS00535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N74_RS00540	COG2239	Acts as a magnesium transporter
E4N74_RS00550	COG0546	phosphoglycolate phosphatase activity
E4N74_RS00560	COG3118	belongs to the thioredoxin family
E4N74_RS00570	COG1120	ATPase activity
E4N74_RS00575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N74_RS00590	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N74_RS00590	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N74_RS00595	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N74_RS00630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4N74_RS00640	COG1757	Na H antiporter
E4N74_RS00645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N74_RS00650	COG4443	Transcriptional Coactivator p15 (PC4)
E4N74_RS00655	COG0328	RNA-DNA hybrid ribonuclease activity
E4N74_RS00665	COG0301	tRNA thio-modification
E4N74_RS00695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N74_RS00700	COG1121	(ABC) transporter
E4N74_RS00710	COG4988	ABC transporter
E4N74_RS00715	COG1132	(ABC) transporter
E4N74_RS00745	COG0335	large ribosomal subunit rRNA binding
E4N74_RS00750	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N74_RS00755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N74_RS00760	COG1837	Belongs to the UPF0109 family
E4N74_RS00765	COG0228	four-way junction DNA binding
E4N74_RS00795	COG3842	ATPase activity
E4N74_RS00805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N74_RS00810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N74_RS00815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N74_RS00840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N74_RS00860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N74_RS00865	COG1285	pathogenesis
E4N74_RS00885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N74_RS00890	COG0534	Mate efflux family protein
E4N74_RS00895	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N74_RS00900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4N74_RS00905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N74_RS00920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4N74_RS00925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N74_RS00930	COG0116	Belongs to the methyltransferase superfamily
E4N74_RS00935	COG3735	TraB family
E4N74_RS00945	COG0791	NLP P60 protein
E4N74_RS00950	COG0318	PFAM AMP-dependent synthetase and ligase
E4N74_RS00970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N74_RS01015	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N74_RS01025	COG0732	type I restriction modification DNA specificity domain
E4N74_RS01040	COG4974	Belongs to the 'phage' integrase family
E4N74_RS01050	COG0732	type I restriction modification DNA specificity domain
E4N74_RS01070	COG1979	alcohol dehydrogenase
E4N74_RS01120	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N74_RS01130	COG3340	Belongs to the peptidase S51 family
E4N74_RS01135	COG0698	ribose 5-phosphate isomerase
E4N74_RS01140	COG0039	L-malate dehydrogenase activity
E4N74_RS01145	COG0534	Mate efflux family protein
E4N74_RS01150	COG0574	Belongs to the PEP-utilizing enzyme family
E4N74_RS01150	COG3848	Pyruvate phosphate dikinase
E4N74_RS01155	COG1309	transcriptional regulator
E4N74_RS01170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N74_RS01190	COG1477	protein flavinylation
E4N74_RS01195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N74_RS01200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N74_RS01215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N74_RS01235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N74_RS01240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N74_RS01245	COG1862	Preprotein translocase
E4N74_RS01250	COG0629	single-stranded DNA binding
E4N74_RS01260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4N74_RS01265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4N74_RS01280	COG0482	sulfurtransferase activity
E4N74_RS01290	COG0351	phosphomethylpyrimidine kinase
E4N74_RS01300	COG1131	(ABC) transporter
E4N74_RS01325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4N74_RS01330	COG0406	alpha-ribazole phosphatase activity
E4N74_RS01335	COG0322	excinuclease ABC activity
E4N74_RS01345	COG1921	L-seryl-tRNASec selenium transferase activity
E4N74_RS01365	COG0577	efflux transmembrane transporter activity
E4N74_RS01365	COG1136	(ABC) transporter
E4N74_RS01370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N74_RS01390	COG1639	'signal transduction protein
E4N74_RS01395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N74_RS01405	COG0101	tRNA pseudouridine synthase activity
E4N74_RS01420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N74_RS01465	COG1132	(ABC) transporter
E4N74_RS01475	COG0826	peptidase U32
E4N74_RS01480	COG3142	Participates in the control of copper homeostasis
E4N74_RS01540	COG3876	Protein conserved in bacteria
E4N74_RS01545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N74_RS01560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N74_RS01565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N74_RS01570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N74_RS01575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4N74_RS01580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N74_RS01585	COG0484	heat shock protein binding
E4N74_RS01590	COG0528	UMP kinase activity
E4N74_RS01595	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N74_RS01610	COG0539	negative regulation of cytoplasmic translation
E4N74_RS01615	COG2204	response regulator
E4N74_RS01620	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N74_RS01640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4N74_RS01665	COG0251	oxidation-reduction process
E4N74_RS01690	COG2197	response regulator
E4N74_RS01695	COG1131	(ABC) transporter
E4N74_RS01710	COG4585	Histidine kinase
E4N74_RS01715	COG0542	response to heat
E4N74_RS01735	COG2949	membrane
E4N74_RS01745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N74_RS01760	COG1692	metallophosphoesterase
E4N74_RS01770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N74_RS01780	COG0484	heat shock protein binding
E4N74_RS01785	COG2089	acid synthase
E4N74_RS01790	COG5341	Protein conserved in bacteria
E4N74_RS01795	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4N74_RS01800	COG0584	glycerophosphoryl diester phosphodiesterase
E4N74_RS01805	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N74_RS01810	COG1704	LemA family
E4N74_RS01815	COG0018	arginyl-trna synthetase
E4N74_RS01820	COG1040	competence protein
E4N74_RS01825	COG2003	Belongs to the UPF0758 family
E4N74_RS01830	COG1686	Belongs to the peptidase S11 family
E4N74_RS01835	COG0017	Asparaginyl-tRNA synthetase
E4N74_RS01845	COG2116	formate transmembrane transporter activity
E4N74_RS01850	COG2084	Dehydrogenase
E4N74_RS01855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4N74_RS01870	COG4786	Flagellar basal body rod
E4N74_RS01880	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N74_RS01885	COG1690	Belongs to the RtcB family
E4N74_RS01945	COG0840	transmembrane signaling receptor activity
E4N74_RS01955	COG1132	(ABC) transporter
E4N74_RS01960	COG1132	(ABC) transporter
E4N74_RS01965	COG1132	(ABC) transporter
E4N74_RS01990	COG1132	(ABC) transporter
E4N74_RS01995	COG1129	ABC transporter
E4N74_RS02015	COG5492	domain, Protein
E4N74_RS02035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N74_RS02050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N74_RS02075	COG2604	Protein of unknown function DUF115
E4N74_RS02100	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N74_RS02110	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N74_RS02130	COG0442	prolyl-tRNA aminoacylation
E4N74_RS02145	COG1879	ABC-type sugar transport system periplasmic component
E4N74_RS02170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N74_RS02175	COG0666	response to abiotic stimulus
E4N74_RS02180	COG3885	ferrous iron binding
E4N74_RS02180	COG2078	PFAM AMMECR1 domain protein
E4N74_RS02195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4N74_RS02200	COG0281	malic enzyme
E4N74_RS02220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N74_RS02225	COG0444	Belongs to the ABC transporter superfamily
E4N74_RS02230	COG4608	Belongs to the ABC transporter superfamily
E4N74_RS02235	COG0426	domain, Protein
E4N74_RS02235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N74_RS02245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N74_RS02250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4N74_RS02265	COG0564	pseudouridine synthase activity
E4N74_RS02270	COG0285	dihydrofolate synthase activity
E4N74_RS02280	COG1561	YicC-like family, N-terminal region
E4N74_RS02285	COG1102	Psort location Cytoplasmic, score
E4N74_RS02290	COG3706	GGDEF domain
E4N74_RS02300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N74_RS02325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N74_RS02330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N74_RS02350	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4N74_RS02360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N74_RS02380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N74_RS02440	COG2376	Dihydroxyacetone kinase
E4N74_RS02445	COG2376	Dihydroxyacetone kinase
E4N74_RS02455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N74_RS02480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4N74_RS02485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N74_RS02490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N74_RS02500	COG0779	Required for maturation of 30S ribosomal subunits
E4N74_RS02520	COG0563	adenylate kinase activity
E4N74_RS02525	COG3033	Beta-eliminating lyase
E4N74_RS02545	COG1366	Belongs to the anti-sigma-factor antagonist family
E4N74_RS02585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N74_RS02590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4N74_RS02610	COG0459	protein refolding
E4N74_RS02630	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N74_RS02635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N74_RS02650	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N74_RS02655	COG3681	Belongs to the UPF0597 family
E4N74_RS02660	COG4953	penicillin-binding protein 1C
E4N74_RS02670	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N74_RS02675	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4N74_RS02685	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N74_RS02690	COG1671	Belongs to the UPF0178 family
E4N74_RS02700	COG0741	lytic transglycosylase activity
E4N74_RS02700	COG1388	LysM domain
E4N74_RS02780	COG0058	SHG alpha-glucan phosphorylase activity
E4N74_RS02790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N74_RS02815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4N74_RS02850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N74_RS02860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N74_RS02865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4N74_RS02870	COG4750	Nucleotidyl transferase
E4N74_RS02875	COG1115	amino acid carrier protein
E4N74_RS02895	COG1193	negative regulation of DNA recombination
E4N74_RS02950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N74_RS02960	COG1702	phosphate starvation-inducible protein PhoH
E4N74_RS02975	COG0149	triose-phosphate isomerase activity
E4N74_RS02980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N74_RS03000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N74_RS03020	COG2885	chlorophyll binding
E4N74_RS03035	COG1199	ATP-dependent helicase activity
E4N74_RS03045	COG0823	Involved in the tonB-independent uptake of proteins
E4N74_RS03060	COG4254	PFAM FecR protein
E4N74_RS03105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N74_RS03110	COG1286	toxin biosynthetic process
E4N74_RS03115	COG0470	DNA polymerase III
E4N74_RS03120	COG3852	Histidine kinase
E4N74_RS03125	COG2204	response regulator
E4N74_RS03130	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N74_RS03145	COG0475	glutathione-regulated potassium exporter activity
E4N74_RS03150	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N74_RS03210	COG0456	acetyltransferase
E4N74_RS03220	COG0535	radical SAM domain protein
E4N74_RS03230	COG1733	regulation of RNA biosynthetic process
E4N74_RS03245	COG1234	tRNA 3'-trailer cleavage
E4N74_RS03255	COG0556	nucleotide-excision repair
E4N74_RS03260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N74_RS03260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N74_RS03265	COG0557	exoribonuclease II activity
E4N74_RS03290	COG4115	mRNA cleavage
E4N74_RS03305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N74_RS03335	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N74_RS03340	COG0640	Transcriptional regulator
E4N74_RS03345	COG2217	Heavy metal translocating P-type atpase
E4N74_RS03355	COG0564	pseudouridine synthase activity
E4N74_RS03370	COG4656	Part of a membrane complex involved in electron transport
E4N74_RS03415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N74_RS03420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N74_RS03420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N74_RS03435	COG0488	(ABC) transporter
E4N74_RS03445	COG0047	phosphoribosylformylglycinamidine synthase activity
E4N74_RS03455	COG1078	dGTPase activity
E4N74_RS03480	COG0475	glutathione-regulated potassium exporter activity
E4N74_RS03500	COG0028	Belongs to the TPP enzyme family
E4N74_RS03500	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4N74_RS03510	COG1373	ATPase (AAA superfamily
E4N74_RS03575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N74_RS03585	COG1215	transferase activity, transferring glycosyl groups
E4N74_RS03590	COG1215	transferase activity, transferring glycosyl groups
E4N74_RS03605	COG1215	transferase activity, transferring glycosyl groups
E4N74_RS03610	COG1215	transferase activity, transferring glycosyl groups
E4N74_RS03610	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4N74_RS03640	COG0463	Glycosyl transferase, family 2
E4N74_RS03645	COG3306	glycosyltransferase involved in LPS biosynthesis
E4N74_RS03655	COG1215	transferase activity, transferring glycosyl groups
E4N74_RS03665	COG0706	membrane insertase activity
E4N74_RS03670	COG0706	membrane insertase activity
E4N74_RS03680	COG0706	membrane insertase activity
E4N74_RS03690	COG0706	membrane insertase activity
E4N74_RS03695	COG0706	membrane insertase activity
E4N74_RS03705	COG0297	glycogen (starch) synthase activity
E4N74_RS03710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N74_RS03725	COG0124	histidyl-tRNA synthetase
E4N74_RS03735	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N74_RS03745	COG0488	(ABC) transporter
E4N74_RS03755	COG0793	Belongs to the peptidase S41A family
E4N74_RS03815	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N74_RS03820	COG0632	four-way junction helicase activity
E4N74_RS03895	COG1136	(ABC) transporter
E4N74_RS03975	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4N74_RS03990	COG2207	Transcriptional regulator
E4N74_RS03990	COG3708	Transcriptional regulator
E4N74_RS04020	COG4115	mRNA cleavage
E4N74_RS04035	COG2361	Protein of unknown function DUF86
E4N74_RS04100	COG1733	regulation of RNA biosynthetic process
E4N74_RS04120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N74_RS04125	COG2878	Part of a membrane complex involved in electron transport
E4N74_RS04130	COG0481	GTPase activity
E4N74_RS04165	COG1114	Component of the transport system for branched-chain amino acids
E4N74_RS04180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N74_RS04205	COG2723	6-phospho-beta-galactosidase activity
E4N74_RS04210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N74_RS04220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N74_RS04225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N74_RS04240	COG0799	negative regulation of ribosome biogenesis
E4N74_RS04245	COG2059	Chromate
E4N74_RS04255	COG0484	heat shock protein binding
E4N74_RS04260	COG0024	Methionine aminopeptidase
E4N74_RS04265	COG0708	Exodeoxyribonuclease III
E4N74_RS04275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N74_RS04285	COG0739	heme binding
E4N74_RS04345	COG0617	tRNA 3'-terminal CCA addition
E4N74_RS04375	COG1846	Transcriptional regulator
E4N74_RS04380	COG0519	Catalyzes the synthesis of GMP from XMP
E4N74_RS04395	COG0126	phosphoglycerate kinase activity
E4N74_RS04400	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N74_RS04420	COG0268	Binds directly to 16S ribosomal RNA
E4N74_RS04430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N74_RS04440	COG1546	Belongs to the CinA family
E4N74_RS04440	COG1058	Belongs to the CinA family
E4N74_RS04470	COG0588	phosphoglycerate mutase activity
E4N74_RS04495	COG1131	(ABC) transporter
E4N74_RS04505	COG0457	Tetratricopeptide repeat
E4N74_RS04510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N74_RS04515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N74_RS04520	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N74_RS04525	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N74_RS04530	COG1394	ATPase activity, coupled to movement of substances
E4N74_RS04535	COG1269	ATP hydrolysis coupled proton transport
E4N74_RS04545	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N74_RS04550	COG0629	single-stranded DNA binding
E4N74_RS04555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N74_RS04560	COG0359	binds to the 23S rRNA
E4N74_RS04570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N74_RS04575	COG0740	serine-type endopeptidase activity
E4N74_RS04580	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N74_RS04600	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N74_RS04610	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N74_RS04625	COG2885	chlorophyll binding
E4N74_RS04630	COG0305	Participates in initiation and elongation during chromosome replication
E4N74_RS04670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N74_RS04675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N74_RS04680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4N74_RS04710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N74_RS04715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N74_RS04720	COG2033	superoxide reductase activity
E4N74_RS04760	COG0497	DNA recombination
E4N74_RS04780	COG1388	LysM domain
E4N74_RS04780	COG0791	NLP P60 protein
E4N74_RS04790	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N74_RS04795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N74_RS04800	COG0312	modulator of DNA gyrase
E4N74_RS04805	COG0312	modulator of DNA gyrase
E4N74_RS04820	COG1692	metallophosphoesterase
E4N74_RS04830	COG0142	geranyltranstransferase activity
E4N74_RS04835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N74_RS04855	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4N74_RS04870	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N74_RS04890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N74_RS04905	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4N74_RS04910	COG2721	sulfolactate sulfo-lyase activity
E4N74_RS04920	COG1349	DNA-binding transcription factor activity
E4N74_RS04925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N74_RS04960	COG1047	Peptidyl-prolyl cis-trans
E4N74_RS04975	COG0731	radical SAM domain protein
E4N74_RS04990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N74_RS04995	COG1979	alcohol dehydrogenase
E4N74_RS05000	COG2255	four-way junction helicase activity
E4N74_RS05005	COG1725	Transcriptional regulator
E4N74_RS05010	COG0653	protein targeting
E4N74_RS05015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4N74_RS05020	COG0138	bifunctional purine biosynthesis protein purh
E4N74_RS05025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4N74_RS05030	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N74_RS05035	COG0205	6-phosphofructokinase activity
E4N74_RS05040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N74_RS05065	COG2982	Protein involved in outer membrane biogenesis
E4N74_RS05070	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4N74_RS05075	COG0297	glycogen (starch) synthase activity
E4N74_RS05095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N74_RS05110	COG0835	chemotaxis
E4N74_RS05120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N74_RS05125	COG0488	(ABC) transporter
E4N74_RS05135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N74_RS05135	COG0493	'glutamate synthase
E4N74_RS05140	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4N74_RS05145	COG1129	ABC transporter
E4N74_RS05175	COG4581	dead DEAH box helicase
E4N74_RS05210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N74_RS05230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N74_RS05240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N74_RS05245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N74_RS05250	COG0509	glycine decarboxylation via glycine cleavage system
E4N74_RS05255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N74_RS05265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4N74_RS05295	COG3052	prosthetic group binding
E4N74_RS05300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N74_RS05300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N74_RS05300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N74_RS05305	COG0237	dephospho-CoA kinase activity
E4N74_RS05315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N74_RS05320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N74_RS05335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N74_RS05350	COG1122	ATPase activity
E4N74_RS05355	COG1268	BioY protein
E4N74_RS05415	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N74_RS05445	COG1136	(ABC) transporter
E4N74_RS05450	COG0577	efflux transmembrane transporter activity
E4N74_RS05465	COG3470	protein probably involved in high-affinity Fe2 transport
E4N74_RS05470	COG0672	)-iron permease
E4N74_RS05480	COG1136	(ABC) transporter
E4N74_RS05490	COG1760	l-serine dehydratase
E4N74_RS05495	COG1760	l-serine dehydratase
E4N74_RS05505	COG0254	rRNA binding
E4N74_RS05510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N74_RS05525	COG0574	Belongs to the PEP-utilizing enzyme family
E4N74_RS05525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N74_RS05535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4N74_RS05545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N74_RS05555	COG1196	nuclear chromosome segregation
E4N74_RS05565	COG2201	protein-glutamate methylesterase activity
E4N74_RS05575	COG0835	chemotaxis
E4N74_RS05580	COG0643	Histidine kinase
E4N74_RS05580	COG2198	Histidine kinase
E4N74_RS05595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N74_RS05600	COG0217	transcriptional regulatory protein
E4N74_RS05635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N74_RS05640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N74_RS05650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N74_RS05650	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N74_RS05665	COG0802	atpase or kinase
E4N74_RS05675	COG2770	Histidine kinase
E4N74_RS05675	COG3437	response regulator, receiver
E4N74_RS05680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N74_RS05685	COG0681	Belongs to the peptidase S26 family
E4N74_RS05690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N74_RS05715	COG0330	HflC and HflK could
E4N74_RS05720	COG0330	HflC and HflK could
E4N74_RS05730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N74_RS05760	COG1739	Uncharacterized protein family UPF0029
E4N74_RS05785	COG2604	Protein of unknown function DUF115
E4N74_RS05790	COG0768	penicillin binding
E4N74_RS05800	COG0433	COG0433 Predicted ATPase
E4N74_RS05815	COG0009	L-threonylcarbamoyladenylate synthase
E4N74_RS05860	COG2190	(PTS) system
E4N74_RS05860	COG2211	Major facilitator Superfamily
E4N74_RS05875	COG1193	negative regulation of DNA recombination
E4N74_RS05880	COG1162	GTPase activity
E4N74_RS05890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N74_RS05905	COG4166	transmembrane transport
E4N74_RS05925	COG0525	valine-tRNA ligase activity
E4N74_RS05930	COG2252	PERMEase
E4N74_RS05955	COG0772	Belongs to the SEDS family
E4N74_RS05960	COG0768	penicillin binding
E4N74_RS05975	COG1077	Cell shape determining protein MreB Mrl
E4N74_RS05995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N74_RS06000	COG0358	DNA primase activity
E4N74_RS06005	COG0606	chelatase, subunit chli
E4N74_RS06020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N74_RS06025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N74_RS06035	COG1164	Oligoendopeptidase f
E4N74_RS06080	COG2375	cellular response to nickel ion
E4N74_RS06080	COG1132	(ABC) transporter
E4N74_RS06090	COG1132	(ABC) transporter
E4N74_RS06265	COG2885	chlorophyll binding
E4N74_RS06270	COG0084	hydrolase, TatD family'
E4N74_RS06280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N74_RS06290	COG0438	transferase activity, transferring glycosyl groups
E4N74_RS06295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N74_RS06305	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N74_RS06310	COG3880	PFAM UvrB UvrC protein
E4N74_RS06320	COG1136	(ABC) transporter
E4N74_RS06325	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N74_RS06335	COG0552	protein localization to endoplasmic reticulum
E4N74_RS06385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4N74_RS06390	COG4475	Protein of unknown function (DUF436)
E4N74_RS06410	COG0601	transmembrane transport
E4N74_RS06415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N74_RS06425	COG0444	Belongs to the ABC transporter superfamily
E4N74_RS06430	COG4608	Belongs to the ABC transporter superfamily
E4N74_RS06455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E4N74_RS06465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N74_RS06470	COG3118	belongs to the thioredoxin family
E4N74_RS06475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N74_RS06480	COG0457	Tetratricopeptide repeat
E4N74_RS06485	COG0037	tRNA processing
E4N74_RS06490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N74_RS06500	COG2088	sporulation resulting in formation of a cellular spore
E4N74_RS06505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N74_RS06530	COG0295	cytidine deaminase activity
E4N74_RS06600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N74_RS06630	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N74_RS06635	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N74_RS06640	COG3845	ABC transporter
E4N74_RS06645	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N74_RS06650	COG1363	Peptidase, m42
E4N74_RS06655	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N74_RS06670	COG0740	serine-type endopeptidase activity
E4N74_RS06685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N74_RS06695	COG1847	R3H domain protein
E4N74_RS06700	COG0706	membrane insertase activity
E4N74_RS06705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N74_RS06715	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4N74_RS06725	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N74_RS06730	COG1121	(ABC) transporter
E4N74_RS06735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N74_RS06740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N74_RS06750	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N74_RS06765	COG1157	protein secretion by the type III secretion system
E4N74_RS06770	COG1317	bacterial-type flagellum organization
E4N74_RS06780	COG1766	The M ring may be actively involved in energy transduction
E4N74_RS06785	COG1677	Flagellar hook-basal body complex protein FliE
E4N74_RS06800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N74_RS06805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N74_RS06810	COG4974	Belongs to the 'phage' integrase family
E4N74_RS06815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N74_RS06815	COG0551	DNA topoisomerase type I activity
E4N74_RS06820	COG0758	DNA mediated transformation
E4N74_RS06835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N74_RS06850	COG0772	Belongs to the SEDS family
E4N74_RS06855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N74_RS06865	COG0275	rRNA processing
E4N74_RS06870	COG2001	Belongs to the MraZ family
E4N74_RS06875	COG1505	serine-type exopeptidase activity
E4N74_RS06915	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4N74_RS06925	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4N74_RS06930	COG0495	leucyl-tRNA aminoacylation
E4N74_RS06940	COG0750	zinc metalloprotease
E4N74_RS06945	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N74_RS06950	COG0575	Belongs to the CDS family
E4N74_RS06955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N74_RS06960	COG0233	cytoplasmic translational termination
E4N74_RS06965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N74_RS06970	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N74_RS06975	COG0424	maF-like protein
E4N74_RS06980	COG1413	lyase activity
E4N74_RS07000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N74_RS07005	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4N74_RS07010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4N74_RS07020	COG0739	heme binding
E4N74_RS07020	COG0741	lytic transglycosylase activity
E4N74_RS07020	COG1196	nuclear chromosome segregation
E4N74_RS07045	COG0668	transmembrane transport
E4N74_RS07060	COG0840	transmembrane signaling receptor activity
E4N74_RS07075	COG4166	transmembrane transport
E4N74_RS07080	COG0601	transmembrane transport
E4N74_RS07085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N74_RS07090	COG0444	Belongs to the ABC transporter superfamily
E4N74_RS07095	COG4172	Belongs to the ABC transporter superfamily
E4N74_RS07100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N74_RS07120	COG0425	Belongs to the sulfur carrier protein TusA family
E4N74_RS07135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N74_RS07140	COG1126	abc transporter atp-binding protein
E4N74_RS07150	COG0765	amino acid transport
E4N74_RS07155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N74_RS07170	COG0601	transmembrane transport
E4N74_RS07175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N74_RS07180	COG0444	Belongs to the ABC transporter superfamily
E4N74_RS07185	COG4608	Belongs to the ABC transporter superfamily
E4N74_RS07205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N74_RS07205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N74_RS07245	COG0534	Mate efflux family protein
E4N74_RS07250	COG0840	transmembrane signaling receptor activity
E4N74_RS07255	COG1757	Na H antiporter
E4N74_RS07260	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N74_RS07265	COG3290	protein histidine kinase activity
E4N74_RS07265	COG3829	transcription factor binding
E4N74_RS07290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N74_RS07295	COG0049	tRNA binding
E4N74_RS07300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4N74_RS07315	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N74_RS07315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N74_RS07315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N74_RS07315	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N74_RS07320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4N74_RS07325	COG0626	cystathionine gamma-synthase activity
E4N74_RS07335	COG1757	Na H antiporter
E4N74_RS07370	COG1122	ATPase activity
E4N74_RS07410	COG1770	oligopeptidase
E4N74_RS07430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4N74_RS07450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N74_RS07475	COG0598	Magnesium transport protein CorA
E4N74_RS07480	COG0617	tRNA 3'-terminal CCA addition
E4N74_RS07495	COG0071	Belongs to the small heat shock protein (HSP20) family
E4N74_RS07500	COG0571	ribonuclease III activity
E4N74_RS07505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N74_RS07510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N74_RS07520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4N74_RS07540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N74_RS07540	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4N74_RS07555	COG1067	ATP-dependent peptidase activity
E4N74_RS07565	COG2703	oxygen carrier activity
E4N74_RS07570	COG2183	response to ionizing radiation
E4N74_RS07580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N74_RS07585	COG1722	exodeoxyribonuclease VII activity
E4N74_RS07590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N74_RS07630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N74_RS07640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4N74_RS07645	COG0085	RNA polymerase activity
E4N74_RS07650	COG0222	ribosome binding
E4N74_RS07655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N74_RS07660	COG0081	regulation of translation
E4N74_RS07665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N74_RS07670	COG0250	Participates in transcription elongation, termination and antitermination
E4N74_RS07675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N74_RS07685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N74_RS07715	COG1652	LysM domain
E4N74_RS07735	COG0326	Molecular chaperone. Has ATPase activity
E4N74_RS07745	COG0210	DNA helicase
E4N74_RS07750	COG1132	(ABC) transporter
E4N74_RS07755	COG1132	(ABC) transporter
E4N74_RS07760	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N74_RS07775	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N74_RS07780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N74_RS07790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N74_RS07795	COG0840	transmembrane signaling receptor activity
E4N74_RS07815	COG3956	TIGRFAM MazG family protein
E4N74_RS07820	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N74_RS07840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N74_RS07860	COG1132	(ABC) transporter
E4N74_RS07865	COG1132	(ABC) transporter
E4N74_RS07870	COG1012	belongs to the aldehyde dehydrogenase family
E4N74_RS07875	COG0357	Ribosomal RNA small subunit methyltransferase G
E4N74_RS07915	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N74_RS07935	COG1120	ATPase activity
E4N74_RS07940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N74_RS07945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4N74_RS07955	COG4865	methylaspartate mutase activity
E4N74_RS07960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N74_RS07970	COG0513	Belongs to the DEAD box helicase family
E4N74_RS07975	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N74_RS07995	COG1131	(ABC) transporter
E4N74_RS08000	COG2208	phosphoserine phosphatase activity
E4N74_RS08000	COG2770	Histidine kinase
E4N74_RS08040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4N74_RS08055	COG1272	protein, Hemolysin III
E4N74_RS08060	COG3177	Filamentation induced by cAMP protein fic
E4N74_RS08065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N74_RS08080	COG2378	regulation of single-species biofilm formation
E4N74_RS08100	COG4115	mRNA cleavage
E4N74_RS08110	COG2885	chlorophyll binding
E4N74_RS08115	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N74_RS08115	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N74_RS08115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N74_RS08115	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N74_RS08120	COG0737	Belongs to the 5'-nucleotidase family
E4N74_RS08155	COG0148	phosphopyruvate hydratase activity
E4N74_RS08160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4N74_RS08170	COG2738	Putative neutral zinc metallopeptidase
E4N74_RS08185	COG2226	methyltransferase
E4N74_RS08230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N74_RS08235	COG0671	phosphoesterase, PA-phosphatase related
E4N74_RS08260	COG1022	Amp-dependent synthetase and ligase
E4N74_RS08265	COG1475	DNA binding
E4N74_RS08275	COG0739	heme binding
E4N74_RS08280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N74_RS08280	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N74_RS08295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N74_RS08300	COG0549	Belongs to the carbamate kinase family
E4N74_RS08305	COG0534	Mate efflux family protein
E4N74_RS08310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4N74_RS08315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4N74_RS08330	COG1362	aminopeptidase activity
E4N74_RS08335	COG0445	tRNA wobble uridine modification
E4N74_RS08340	COG0210	DNA helicase
E4N74_RS08360	COG3604	Transcriptional regulator
E4N74_RS08390	COG1573	uracil-dna glycosylase
E4N74_RS08395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N74_RS08400	COG0196	riboflavin kinase activity
E4N74_RS08405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4N74_RS08410	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N74_RS08415	COG0756	dUTP diphosphatase activity
E4N74_RS08430	COG0564	pseudouridine synthase activity
E4N74_RS08435	COG0156	8-amino-7-oxononanoate synthase activity
E4N74_RS08455	COG1132	(ABC) transporter
E4N74_RS08460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N74_RS08465	COG1329	Transcriptional regulator
E4N74_RS08470	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N74_RS08470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N74_RS08475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N74_RS08490	COG0668	transmembrane transport
E4N74_RS08505	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N74_RS08510	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N74_RS08515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N74_RS08530	COG0792	nuclease activity
E4N74_RS08545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N74_RS08560	COG1111	helicase
E4N74_RS08560	COG1205	dead DEAH box helicase
E4N74_RS08580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N74_RS08605	COG0504	CTP synthase activity
E4N74_RS08620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N74_RS08620	COG1747	RNA polymerase binding
E4N74_RS08635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N74_RS08680	COG0330	HflC and HflK could
E4N74_RS08700	COG1129	ABC transporter
E4N74_RS08725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4N74_RS08735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N74_RS08745	COG4608	Belongs to the ABC transporter superfamily
E4N74_RS08760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N74_RS08765	COG0601	transmembrane transport
E4N74_RS08775	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4N74_RS08780	COG4657	Part of a membrane complex involved in electron transport
E4N74_RS08785	COG4660	Part of a membrane complex involved in electron transport
E4N74_RS08795	COG4658	electron transport chain
E4N74_RS08800	COG4656	Part of a membrane complex involved in electron transport
E4N74_RS08810	COG2304	oxidoreductase activity
E4N74_RS08825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N74_RS08825	COG0574	Belongs to the PEP-utilizing enzyme family
E4N74_RS08835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N74_RS08845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4N74_RS08865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N74_RS08880	COG2197	response regulator
E4N74_RS08905	COG1187	pseudouridine synthase activity
E4N74_RS08910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N74_RS08960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N74_RS08975	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N74_RS08980	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N74_RS08990	COG2226	methyltransferase
E4N74_RS09010	COG1254	Belongs to the acylphosphatase family
E4N74_RS09035	COG0203	ribosomal protein L17
E4N74_RS09040	COG0202	RNA polymerase activity
E4N74_RS09045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N74_RS09050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4N74_RS09055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N74_RS09065	COG0200	Binds to the 23S rRNA
E4N74_RS09070	COG1841	ribosomal large subunit assembly
E4N74_RS09075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N74_RS09080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4N74_RS09085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N74_RS09090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N74_RS09095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4N74_RS09100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N74_RS09105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N74_RS09110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N74_RS09115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N74_RS09120	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N74_RS09125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4N74_RS09130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N74_RS09135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N74_RS09140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4N74_RS09145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N74_RS09150	COG0089	rRNA binding
E4N74_RS09155	COG0088	Forms part of the polypeptide exit tunnel
E4N74_RS09160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N74_RS09165	COG0051	transcription antitermination factor activity, RNA binding
E4N74_RS09170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N74_RS09185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N74_RS09195	COG3706	GGDEF domain
E4N74_RS09215	COG3290	protein histidine kinase activity
E4N74_RS09215	COG0840	transmembrane signaling receptor activity
E4N74_RS09220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N74_RS09225	COG0564	pseudouridine synthase activity
E4N74_RS09235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N74_RS09240	COG0166	Belongs to the GPI family
E4N74_RS09245	COG1362	aminopeptidase activity
E4N74_RS09250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4N74_RS09255	COG0724	RNA recognition motif
E4N74_RS09260	COG2211	Major facilitator Superfamily
E4N74_RS09305	COG1266	CAAX protease self-immunity
E4N74_RS09315	COG0396	ATPase activity
E4N74_RS09320	COG0719	Fe-S assembly protein
E4N74_RS09330	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N74_RS09350	COG2201	protein-glutamate methylesterase activity
E4N74_RS09370	COG1137	ATPase activity
E4N74_RS09375	COG0193	aminoacyl-tRNA hydrolase activity
E4N74_RS09385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N74_RS09395	COG0601	transmembrane transport
E4N74_RS09400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N74_RS09405	COG0444	Belongs to the ABC transporter superfamily
E4N74_RS09410	COG4608	Belongs to the ABC transporter superfamily
E4N74_RS09415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4N74_RS09420	COG1876	peptidase activity
E4N74_RS09440	COG0484	heat shock protein binding
E4N74_RS09445	COG0443	Heat shock 70 kDa protein
E4N74_RS09450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N74_RS09475	COG1120	ATPase activity
E4N74_RS09505	COG0534	Mate efflux family protein
E4N74_RS09515	COG0840	transmembrane signaling receptor activity
E4N74_RS09535	COG1192	Involved in chromosome partitioning
E4N74_RS09540	COG1475	DNA binding
E4N74_RS09560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N74_RS09565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N74_RS09570	COG1028	Short-chain dehydrogenase reductase Sdr
E4N74_RS09585	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N74_RS09615	COG0439	Biotin carboxylase
E4N74_RS09620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N74_RS09625	COG0825	malonyl-CoA metabolic process
E4N74_RS09630	COG2986	histidine ammonia-lyase
E4N74_RS09645	COG0714	Associated with various cellular activities
E4N74_RS09680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N74_RS09685	COG0154	amidase activity
E4N74_RS09690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N74_RS09810	COG1136	(ABC) transporter
E4N74_RS09995	COG1396	sequence-specific DNA binding
E4N74_RS10005	COG3550	peptidyl-serine autophosphorylation
E4N74_RS10040	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N74_RS10100	COG1132	(ABC) transporter
E4N74_RS10105	COG1132	(ABC) transporter
E4N74_RS10110	COG0280	phosphate acetyltransferase
E4N74_RS10115	COG0457	Tetratricopeptide repeat
E4N74_RS10120	COG0587	DNA-directed DNA polymerase activity
E4N74_RS10155	COG3177	Filamentation induced by cAMP protein fic
E4N74_RS10170	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N74_RS10180	COG0517	IMP dehydrogenase activity
E4N74_RS10180	COG4175	Glycine betaine
E4N74_RS10200	COG2205	protein histidine kinase activity
E4N74_RS10205	COG1136	(ABC) transporter
E4N74_RS10215	COG0095	Lipoate-protein ligase
E4N74_RS10225	COG1131	(ABC) transporter
E4N74_RS10230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4N74_RS10235	COG1122	ATPase activity
E4N74_RS10280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4N74_RS10290	COG0516	GMP reductase activity
E4N74_RS10295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N74_RS10300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N74_RS10330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N74_RS10360	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4N74_RS10375	COG1774	PSP1 C-terminal conserved region
E4N74_RS10380	COG1728	Protein conserved in bacteria
E4N74_RS10390	COG0739	heme binding
E4N74_RS10405	COG0366	Alpha amylase catalytic
E4N74_RS10415	COG1609	Transcriptional regulator
E4N74_RS10450	COG0543	2 iron, 2 sulfur cluster binding
E4N74_RS10455	COG0784	Response regulator, receiver
E4N74_RS10455	COG3437	response regulator, receiver
E4N74_RS10475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N74_RS10525	COG3177	Filamentation induced by cAMP protein fic
E4N74_RS10540	COG1129	ABC transporter
E4N74_RS10545	COG1132	(ABC) transporter
E4N74_RS10565	COG1132	(ABC) transporter
E4N74_RS10570	COG1309	transcriptional regulator
E4N74_RS10575	COG3189	MarR family transcriptional regulator
E4N74_RS10590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N74_RS10595	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N74_RS10600	COG1684	flagellar biosynthetic protein fliR
E4N74_RS10605	COG1987	bacterial-type flagellum assembly
E4N74_RS10640	COG1228	amidohydrolase
E4N74_RS10680	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N74_RS10685	COG0583	DNA-binding transcription factor activity
E4N74_RS10695	COG0747	negative chemotaxis
E4N74_RS10700	COG4608	Belongs to the ABC transporter superfamily
E4N74_RS10705	COG0444	Belongs to the ABC transporter superfamily
E4N74_RS10710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N74_RS10735	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N74_RS10750	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N74_RS10780	COG1473	amidohydrolase
E4N74_RS10785	COG4585	Histidine kinase
E4N74_RS10790	COG2197	response regulator
E4N74_RS10795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N74_RS10840	COG1401	restriction endodeoxyribonuclease activity
E4N74_RS10875	COG3093	addiction module antidote protein HigA
E4N74_RS10880	COG3549	Plasmid maintenance system killer
E4N74_RS10890	COG0728	peptidoglycan biosynthetic process
E4N74_RS10895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N74_RS10910	COG3588	fructose-bisphosphate aldolase
E4N74_RS10930	COG0012	GTP binding
E4N74_RS10935	COG0616	signal peptide processing
E4N74_RS10940	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4N74_RS10960	COG5012	cobalamin binding
E4N74_RS10965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N74_RS10970	COG1132	(ABC) transporter
E4N74_RS10975	COG1132	(ABC) transporter
E4N74_RS10985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N74_RS10990	COG0363	glucosamine-6-phosphate deaminase activity
E4N74_RS10995	COG0628	permease
E4N74_RS11000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N74_RS11010	COG0534	Mate efflux family protein
E4N74_RS11015	COG1309	transcriptional regulator
E4N74_RS11020	COG0786	glutamate:sodium symporter activity
E4N74_RS11025	COG0840	transmembrane signaling receptor activity
E4N74_RS11030	COG0840	transmembrane signaling receptor activity
E4N74_RS11035	COG0813	purine-nucleoside phosphorylase activity
E4N74_RS11080	COG5002	protein histidine kinase activity
E4N74_RS11080	COG5001	Diguanylate cyclase
E4N74_RS11085	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N74_RS11085	COG0540	Belongs to the ATCase OTCase family
E4N74_RS11115	COG3842	ATPase activity
E4N74_RS11120	COG3833	ABC-type maltose transport systems, permease component
E4N74_RS11125	COG1175	transmembrane transport
E4N74_RS11135	COG1418	mRNA catabolic process
E4N74_RS11140	COG0419	ATPase involved in DNA repair
E4N74_RS11145	COG0420	3'-5' exonuclease activity
E4N74_RS11150	COG3290	protein histidine kinase activity
E4N74_RS11150	COG0840	transmembrane signaling receptor activity
E4N74_RS11160	COG1131	(ABC) transporter
E4N74_RS11180	COG0716	FMN binding
E4N74_RS11195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4N74_RS11200	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N74_RS11205	COG0592	DNA-directed DNA polymerase activity
E4N74_RS11210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N74_RS11295	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
E4N74_RS11360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4N74_RS11375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4N74_RS11380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N74_RS11415	COG2184	nucleotidyltransferase activity
E4N74_RS11425	COG0730	response to heat
E4N74_RS11445	COG4208	sulfate ABC transporter
E4N74_RS11450	COG3839	Belongs to the ABC transporter superfamily
E4N74_RS11470	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N74_RS11475	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N74_RS11480	COG1674	ftsk spoiiie
E4N74_RS11485	COG1968	undecaprenyl-diphosphatase activity
E4N74_RS11495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N74_RS11515	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4N74_RS11520	COG0534	Mate efflux family protein
E4N74_RS11525	COG0569	domain protein
E4N74_RS11530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N74_RS11550	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4N74_RS11555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N74_RS11570	COG2235	arginine
E4N74_RS11575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N74_RS11585	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N74_RS11590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N74_RS11595	COG0569	domain protein
E4N74_RS11605	COG1487	ribonuclease activity
E4N74_RS11620	COG0714	Associated with various cellular activities
E4N74_RS11625	COG4536	flavin adenine dinucleotide binding
E4N74_RS11630	COG4536	flavin adenine dinucleotide binding
E4N74_RS11645	COG0514	ATP-dependent DNA helicase (RecQ)
E4N74_RS11655	COG1518	maintenance of DNA repeat elements
E4N74_RS11660	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4N74_RS11675	COG4988	ABC transporter
E4N74_RS11700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N74_RS11710	COG2274	protein secretion by the type I secretion system
E4N74_RS11710	COG3271	cysteine-type peptidase activity
E4N74_RS11715	COG1132	(ABC) transporter
E4N74_RS11720	COG0438	transferase activity, transferring glycosyl groups
E4N74_RS11725	COG3842	ATPase activity
E4N74_RS11745	COG3706	GGDEF domain
E4N74_RS11760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N74_RS11765	COG0215	cysteine-tRNA ligase activity
E4N74_RS11780	COG1305	Transglutaminase-like
E4N74_RS11785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N74_RS11790	COG0569	domain protein
E4N74_RS11795	COG2887	Belongs to the helicase family. UvrD subfamily
E4N74_RS11800	COG1074	ATP-dependent DNA helicase activity
E4N74_RS11805	COG0210	DNA helicase
E4N74_RS11840	COG1074	ATP-dependent DNA helicase activity
E4N74_RS11850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N74_RS11900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N74_RS11910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N74_RS11920	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N74_RS11930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N74_RS11940	COG4555	ABC transporter
E4N74_RS11955	COG0840	transmembrane signaling receptor activity
E4N74_RS11985	COG1151	hydroxylamine reductase activity
E4N74_RS12005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4N74_RS12010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N74_RS12030	COG1401	restriction endodeoxyribonuclease activity
E4N74_RS12040	COG4946	Tricorn protease homolog
E4N74_RS12040	COG1506	peptidase
E4N74_RS12040	COG0823	Involved in the tonB-independent uptake of proteins
E4N74_RS12055	COG1104	cysteine desulfurase activity
E4N74_RS12060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4N74_RS12065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N74_RS12085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N74_RS12100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N74_RS12110	COG1929	Belongs to the glycerate kinase type-1 family
E4N74_RS12115	COG2217	Heavy metal translocating P-type atpase
E4N74_RS12125	COG0494	nUDIX hydrolase
E4N74_RS12130	COG0783	Belongs to the Dps family
E4N74_RS12135	COG0450	alkyl hydroperoxide reductase
E4N74_RS12140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N74_RS12160	COG1363	Peptidase, m42
E4N74_RS12170	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N74_RS12175	COG0423	glycine-tRNA ligase activity
E4N74_RS12195	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N74_RS12305	COG1129	ABC transporter
E4N74_RS12320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4N74_RS12335	COG0561	phosphatase activity
E4N74_RS12360	COG1011	Hydrolase
E4N74_RS12375	COG1132	(ABC) transporter
E4N74_RS12380	COG2375	cellular response to nickel ion
E4N74_RS12380	COG1132	(ABC) transporter
E4N74_RS12415	COG0456	acetyltransferase
E4N74_RS12450	COG1129	ABC transporter
E4N74_RS12465	COG1309	transcriptional regulator
E4N74_RS12520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N74_RS12555	COG1191	sigma factor activity
E4N74_RS12570	COG1419	protein localization to endoplasmic reticulum
E4N74_RS12575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N74_RS12595	COG1132	(ABC) transporter
E4N74_RS12610	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N74_RS12625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N74_RS12635	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N74_RS12640	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N74_RS12645	COG1776	CheC inhibitor of MCP methylation
E4N74_RS12645	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N74_RS12655	COG1338	Plays a role in the flagellum-specific transport system
E4N74_RS12685	COG4166	transmembrane transport
E4N74_RS12690	COG2423	ornithine cyclodeaminase activity
E4N74_RS12695	COG0741	lytic transglycosylase activity
E4N74_RS12695	COG0739	heme binding
E4N74_RS12695	COG1196	nuclear chromosome segregation
E4N74_RS12700	COG4545	Glutaredoxin-related protein
E4N74_RS12715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4N74_RS12730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N74_RS12730	COG3116	cell division
E4N74_RS12735	COG0084	hydrolase, TatD family'
E4N74_RS12745	COG2203	Gaf domain
E4N74_RS12745	COG2199	diguanylate cyclase activity
E4N74_RS12775	COG0187	DNA topoisomerase II activity