locus-tag	class	description
E4N75_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N75_RS00050	COG0577	efflux transmembrane transporter activity
E4N75_RS00050	COG1136	(ABC) transporter
E4N75_RS00055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4N75_RS00110	COG1266	CAAX protease self-immunity
E4N75_RS00120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N75_RS00155	COG1012	belongs to the aldehyde dehydrogenase family
E4N75_RS00180	COG1012	belongs to the aldehyde dehydrogenase family
E4N75_RS00210	COG0531	amino acid
E4N75_RS00215	COG0196	riboflavin kinase activity
E4N75_RS00220	COG0196	riboflavin kinase activity
E4N75_RS00225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N75_RS00245	COG0840	transmembrane signaling receptor activity
E4N75_RS00250	COG0826	peptidase U32
E4N75_RS00260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N75_RS00265	COG1509	lysine 2,3-aminomutase activity
E4N75_RS00270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N75_RS00275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N75_RS00290	COG0205	6-phosphofructokinase activity
E4N75_RS00340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N75_RS00360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N75_RS00415	COG1652	LysM domain
E4N75_RS00415	COG2823	Periplasmic or secreted lipoprotein
E4N75_RS00425	COG1592	Rubrerythrin
E4N75_RS00430	COG0514	ATP-dependent DNA helicase (RecQ)
E4N75_RS00435	COG1381	Involved in DNA repair and RecF pathway recombination
E4N75_RS00445	COG0343	queuine tRNA-ribosyltransferase activity
E4N75_RS00500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4N75_RS00515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N75_RS00525	COG4555	ABC transporter
E4N75_RS00545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N75_RS00550	COG2239	Acts as a magnesium transporter
E4N75_RS00560	COG0546	phosphoglycolate phosphatase activity
E4N75_RS00570	COG3118	belongs to the thioredoxin family
E4N75_RS00580	COG1120	ATPase activity
E4N75_RS00585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N75_RS00600	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N75_RS00600	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N75_RS00605	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4N75_RS00640	COG1757	Na H antiporter
E4N75_RS00645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N75_RS00650	COG4443	Transcriptional Coactivator p15 (PC4)
E4N75_RS00655	COG0328	RNA-DNA hybrid ribonuclease activity
E4N75_RS00665	COG0301	tRNA thio-modification
E4N75_RS00695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N75_RS00700	COG1121	(ABC) transporter
E4N75_RS00710	COG4988	ABC transporter
E4N75_RS00715	COG4988	ABC transporter
E4N75_RS00720	COG1132	(ABC) transporter
E4N75_RS00750	COG0335	large ribosomal subunit rRNA binding
E4N75_RS00755	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N75_RS00760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N75_RS00765	COG1837	Belongs to the UPF0109 family
E4N75_RS00770	COG0228	four-way junction DNA binding
E4N75_RS00780	COG1136	(ABC) transporter
E4N75_RS00780	COG0577	efflux transmembrane transporter activity
E4N75_RS00790	COG1136	(ABC) transporter
E4N75_RS00800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N75_RS00805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N75_RS00810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N75_RS00820	COG1902	pentaerythritol trinitrate reductase activity
E4N75_RS00820	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N75_RS00835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N75_RS00855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N75_RS00860	COG1285	pathogenesis
E4N75_RS00880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N75_RS00885	COG0534	Mate efflux family protein
E4N75_RS00890	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N75_RS00895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4N75_RS00900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N75_RS00915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4N75_RS00920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N75_RS00925	COG0116	Belongs to the methyltransferase superfamily
E4N75_RS00930	COG3735	TraB family
E4N75_RS00940	COG0791	NLP P60 protein
E4N75_RS00945	COG0318	PFAM AMP-dependent synthetase and ligase
E4N75_RS00965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N75_RS01010	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N75_RS01035	COG0732	type I restriction modification DNA specificity domain
E4N75_RS01040	COG4974	Belongs to the 'phage' integrase family
E4N75_RS01065	COG1979	alcohol dehydrogenase
E4N75_RS01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N75_RS01125	COG3340	Belongs to the peptidase S51 family
E4N75_RS01130	COG0698	ribose 5-phosphate isomerase
E4N75_RS01135	COG0039	L-malate dehydrogenase activity
E4N75_RS01145	COG0574	Belongs to the PEP-utilizing enzyme family
E4N75_RS01145	COG3848	Pyruvate phosphate dikinase
E4N75_RS01150	COG1309	transcriptional regulator
E4N75_RS01165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N75_RS01185	COG1477	protein flavinylation
E4N75_RS01190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N75_RS01195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N75_RS01210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N75_RS01230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N75_RS01235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N75_RS01240	COG1862	Preprotein translocase
E4N75_RS01245	COG0629	single-stranded DNA binding
E4N75_RS01255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4N75_RS01260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4N75_RS01275	COG0482	sulfurtransferase activity
E4N75_RS01290	COG1131	(ABC) transporter
E4N75_RS01315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4N75_RS01320	COG0406	alpha-ribazole phosphatase activity
E4N75_RS01325	COG0322	excinuclease ABC activity
E4N75_RS01335	COG1921	L-seryl-tRNASec selenium transferase activity
E4N75_RS01355	COG0577	efflux transmembrane transporter activity
E4N75_RS01355	COG1136	(ABC) transporter
E4N75_RS01360	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4N75_RS01395	COG1639	'signal transduction protein
E4N75_RS01400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N75_RS01410	COG0101	tRNA pseudouridine synthase activity
E4N75_RS01425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N75_RS01475	COG1132	(ABC) transporter
E4N75_RS01480	COG1132	(ABC) transporter
E4N75_RS01485	COG0657	acetylesterase activity
E4N75_RS01490	COG0826	peptidase U32
E4N75_RS01495	COG3142	Participates in the control of copper homeostasis
E4N75_RS01515	COG0463	Glycosyl transferase, family 2
E4N75_RS01530	COG3876	Protein conserved in bacteria
E4N75_RS01535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N75_RS01550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N75_RS01555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N75_RS01560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N75_RS01565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4N75_RS01570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N75_RS01575	COG0484	heat shock protein binding
E4N75_RS01580	COG0528	UMP kinase activity
E4N75_RS01585	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N75_RS01605	COG2204	response regulator
E4N75_RS01610	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N75_RS01635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4N75_RS01660	COG0251	oxidation-reduction process
E4N75_RS01685	COG2197	response regulator
E4N75_RS01690	COG1131	(ABC) transporter
E4N75_RS01705	COG4585	Histidine kinase
E4N75_RS01710	COG0542	response to heat
E4N75_RS01730	COG2949	membrane
E4N75_RS01745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N75_RS01760	COG1692	metallophosphoesterase
E4N75_RS01780	COG0484	heat shock protein binding
E4N75_RS01785	COG2089	acid synthase
E4N75_RS01790	COG5341	Protein conserved in bacteria
E4N75_RS01795	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4N75_RS01800	COG0584	glycerophosphoryl diester phosphodiesterase
E4N75_RS01805	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N75_RS01810	COG1704	LemA family
E4N75_RS01815	COG0018	arginyl-trna synthetase
E4N75_RS01820	COG1040	competence protein
E4N75_RS01825	COG2003	Belongs to the UPF0758 family
E4N75_RS01830	COG1686	Belongs to the peptidase S11 family
E4N75_RS01835	COG0017	Asparaginyl-tRNA synthetase
E4N75_RS01845	COG2116	formate transmembrane transporter activity
E4N75_RS01850	COG2084	Dehydrogenase
E4N75_RS01855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4N75_RS01880	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N75_RS01885	COG1690	Belongs to the RtcB family
E4N75_RS01960	COG1132	(ABC) transporter
E4N75_RS01965	COG1132	(ABC) transporter
E4N75_RS01970	COG1132	(ABC) transporter
E4N75_RS01995	COG1132	(ABC) transporter
E4N75_RS02000	COG1129	ABC transporter
E4N75_RS02020	COG5492	domain, Protein
E4N75_RS02030	COG2801	Transposase and inactivated derivatives
E4N75_RS02035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N75_RS02035	COG0551	DNA topoisomerase type I activity
E4N75_RS02060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4N75_RS02085	COG3451	type IV secretory pathway VirB4
E4N75_RS02110	COG2948	multi-organism process
E4N75_RS02190	COG2003	Belongs to the UPF0758 family
E4N75_RS02270	COG2268	Band 7 protein
E4N75_RS02325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N75_RS02340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N75_RS02365	COG2604	Protein of unknown function DUF115
E4N75_RS02395	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N75_RS02405	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N75_RS02430	COG0442	prolyl-tRNA aminoacylation
E4N75_RS02445	COG1879	ABC-type sugar transport system periplasmic component
E4N75_RS02470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N75_RS02475	COG0666	response to abiotic stimulus
E4N75_RS02480	COG2078	PFAM AMMECR1 domain protein
E4N75_RS02480	COG3885	ferrous iron binding
E4N75_RS02495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4N75_RS02500	COG0281	malic enzyme
E4N75_RS02525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_RS02530	COG0444	Belongs to the ABC transporter superfamily
E4N75_RS02535	COG4608	Belongs to the ABC transporter superfamily
E4N75_RS02545	COG0426	domain, Protein
E4N75_RS02545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N75_RS02560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_RS02565	COG0444	Belongs to the ABC transporter superfamily
E4N75_RS02570	COG4608	Belongs to the ABC transporter superfamily
E4N75_RS02595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_RS02600	COG0444	Belongs to the ABC transporter superfamily
E4N75_RS02605	COG4608	Belongs to the ABC transporter superfamily
E4N75_RS02625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N75_RS02630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4N75_RS02645	COG0564	pseudouridine synthase activity
E4N75_RS02650	COG0285	dihydrofolate synthase activity
E4N75_RS02660	COG1561	YicC-like family, N-terminal region
E4N75_RS02665	COG1102	Psort location Cytoplasmic, score
E4N75_RS02670	COG3706	GGDEF domain
E4N75_RS02680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N75_RS02705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N75_RS02710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N75_RS02730	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4N75_RS02740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N75_RS02760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N75_RS02820	COG2376	Dihydroxyacetone kinase
E4N75_RS02825	COG2376	Dihydroxyacetone kinase
E4N75_RS02835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N75_RS02865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4N75_RS02870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N75_RS02885	COG0779	Required for maturation of 30S ribosomal subunits
E4N75_RS02890	COG0019	diaminopimelate decarboxylase activity
E4N75_RS02905	COG0563	adenylate kinase activity
E4N75_RS02910	COG3033	Beta-eliminating lyase
E4N75_RS02930	COG1366	Belongs to the anti-sigma-factor antagonist family
E4N75_RS02970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N75_RS02975	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4N75_RS02995	COG0459	protein refolding
E4N75_RS03015	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N75_RS03020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N75_RS03035	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N75_RS03040	COG3681	Belongs to the UPF0597 family
E4N75_RS03045	COG4953	penicillin-binding protein 1C
E4N75_RS03055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N75_RS03060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4N75_RS03070	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N75_RS03075	COG1671	Belongs to the UPF0178 family
E4N75_RS03085	COG0741	lytic transglycosylase activity
E4N75_RS03085	COG1388	LysM domain
E4N75_RS03165	COG0058	SHG alpha-glucan phosphorylase activity
E4N75_RS03175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N75_RS03200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4N75_RS03235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N75_RS03245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N75_RS03250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4N75_RS03255	COG4750	Nucleotidyl transferase
E4N75_RS03260	COG1115	amino acid carrier protein
E4N75_RS03280	COG1193	negative regulation of DNA recombination
E4N75_RS03335	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N75_RS03345	COG1702	phosphate starvation-inducible protein PhoH
E4N75_RS03360	COG0149	triose-phosphate isomerase activity
E4N75_RS03365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N75_RS03385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N75_RS03405	COG2885	chlorophyll binding
E4N75_RS03415	COG1199	ATP-dependent helicase activity
E4N75_RS03425	COG0823	Involved in the tonB-independent uptake of proteins
E4N75_RS03440	COG4254	PFAM FecR protein
E4N75_RS03485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N75_RS03490	COG1286	toxin biosynthetic process
E4N75_RS03505	COG3852	Histidine kinase
E4N75_RS03510	COG2204	response regulator
E4N75_RS03515	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N75_RS03530	COG0475	glutathione-regulated potassium exporter activity
E4N75_RS03535	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N75_RS03585	COG0456	acetyltransferase
E4N75_RS03595	COG0535	radical SAM domain protein
E4N75_RS03610	COG1234	tRNA 3'-trailer cleavage
E4N75_RS03620	COG0556	nucleotide-excision repair
E4N75_RS03625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N75_RS03625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N75_RS03630	COG0557	exoribonuclease II activity
E4N75_RS03655	COG4115	mRNA cleavage
E4N75_RS03670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N75_RS03685	COG2274	protein secretion by the type I secretion system
E4N75_RS03710	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N75_RS03715	COG0640	Transcriptional regulator
E4N75_RS03720	COG2217	Heavy metal translocating P-type atpase
E4N75_RS03730	COG0564	pseudouridine synthase activity
E4N75_RS03745	COG4656	Part of a membrane complex involved in electron transport
E4N75_RS03795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N75_RS03795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N75_RS03810	COG0488	(ABC) transporter
E4N75_RS03820	COG0047	phosphoribosylformylglycinamidine synthase activity
E4N75_RS03830	COG1078	dGTPase activity
E4N75_RS03855	COG0475	glutathione-regulated potassium exporter activity
E4N75_RS03875	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4N75_RS03875	COG0028	Belongs to the TPP enzyme family
E4N75_RS03910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N75_RS03925	COG1216	Glycosyl transferase, family 2
E4N75_RS03960	COG1215	transferase activity, transferring glycosyl groups
E4N75_RS03975	COG1215	transferase activity, transferring glycosyl groups
E4N75_RS03990	COG1215	transferase activity, transferring glycosyl groups
E4N75_RS04020	COG3306	glycosyltransferase involved in LPS biosynthesis
E4N75_RS04030	COG0463	Glycosyl transferase, family 2
E4N75_RS04040	COG0706	membrane insertase activity
E4N75_RS04045	COG0706	membrane insertase activity
E4N75_RS04055	COG0706	membrane insertase activity
E4N75_RS04065	COG0706	membrane insertase activity
E4N75_RS04070	COG0706	membrane insertase activity
E4N75_RS04085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N75_RS04100	COG0124	histidyl-tRNA synthetase
E4N75_RS04110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N75_RS04120	COG0488	(ABC) transporter
E4N75_RS04130	COG0793	Belongs to the peptidase S41A family
E4N75_RS04205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N75_RS04210	COG0632	four-way junction helicase activity
E4N75_RS04290	COG1136	(ABC) transporter
E4N75_RS04395	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4N75_RS04405	COG2361	Protein of unknown function DUF86
E4N75_RS04440	COG0539	negative regulation of cytoplasmic translation
E4N75_RS04560	COG4115	mRNA cleavage
E4N75_RS04630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N75_RS04635	COG2878	Part of a membrane complex involved in electron transport
E4N75_RS04640	COG0481	GTPase activity
E4N75_RS04670	COG1114	Component of the transport system for branched-chain amino acids
E4N75_RS04685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N75_RS04715	COG2723	6-phospho-beta-galactosidase activity
E4N75_RS04720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N75_RS04730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N75_RS04735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4N75_RS04750	COG0799	negative regulation of ribosome biogenesis
E4N75_RS04755	COG2059	Chromate
E4N75_RS04765	COG0484	heat shock protein binding
E4N75_RS04770	COG0024	Methionine aminopeptidase
E4N75_RS04775	COG0708	Exodeoxyribonuclease III
E4N75_RS04785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N75_RS04795	COG0739	heme binding
E4N75_RS04875	COG0617	tRNA 3'-terminal CCA addition
E4N75_RS04905	COG1846	Transcriptional regulator
E4N75_RS04910	COG0519	Catalyzes the synthesis of GMP from XMP
E4N75_RS04930	COG0126	phosphoglycerate kinase activity
E4N75_RS04935	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N75_RS04955	COG0268	Binds directly to 16S ribosomal RNA
E4N75_RS04965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N75_RS04975	COG1546	Belongs to the CinA family
E4N75_RS04975	COG1058	Belongs to the CinA family
E4N75_RS05025	COG1131	(ABC) transporter
E4N75_RS05035	COG0457	Tetratricopeptide repeat
E4N75_RS05040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N75_RS05045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N75_RS05050	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N75_RS05055	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N75_RS05060	COG1394	ATPase activity, coupled to movement of substances
E4N75_RS05065	COG1269	ATP hydrolysis coupled proton transport
E4N75_RS05075	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N75_RS05080	COG0629	single-stranded DNA binding
E4N75_RS05085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N75_RS05090	COG0359	binds to the 23S rRNA
E4N75_RS05100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N75_RS05105	COG0740	serine-type endopeptidase activity
E4N75_RS05110	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N75_RS05130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N75_RS05140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N75_RS05155	COG2885	chlorophyll binding
E4N75_RS05160	COG0305	Participates in initiation and elongation during chromosome replication
E4N75_RS05170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N75_RS05185	COG2826	transposase and inactivated derivatives, IS30 family
E4N75_RS05230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N75_RS05235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4N75_RS05265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N75_RS05270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N75_RS05275	COG2033	superoxide reductase activity
E4N75_RS05315	COG0497	DNA recombination
E4N75_RS05335	COG0791	NLP P60 protein
E4N75_RS05335	COG1388	LysM domain
E4N75_RS05350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N75_RS05355	COG0312	modulator of DNA gyrase
E4N75_RS05360	COG0312	modulator of DNA gyrase
E4N75_RS05375	COG1692	metallophosphoesterase
E4N75_RS05385	COG0142	geranyltranstransferase activity
E4N75_RS05390	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N75_RS05410	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4N75_RS05425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N75_RS05445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N75_RS05460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4N75_RS05465	COG2721	sulfolactate sulfo-lyase activity
E4N75_RS05470	COG2721	sulfolactate sulfo-lyase activity
E4N75_RS05480	COG1349	DNA-binding transcription factor activity
E4N75_RS05485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N75_RS05525	COG1047	Peptidyl-prolyl cis-trans
E4N75_RS05540	COG0731	radical SAM domain protein
E4N75_RS05555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N75_RS05560	COG1979	alcohol dehydrogenase
E4N75_RS05565	COG2255	four-way junction helicase activity
E4N75_RS05575	COG1725	Transcriptional regulator
E4N75_RS05580	COG0653	protein targeting
E4N75_RS05585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4N75_RS05590	COG0138	bifunctional purine biosynthesis protein purh
E4N75_RS05595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4N75_RS05600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N75_RS05605	COG0205	6-phosphofructokinase activity
E4N75_RS05610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N75_RS05630	COG2982	Protein involved in outer membrane biogenesis
E4N75_RS05640	COG0297	glycogen (starch) synthase activity
E4N75_RS05655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N75_RS05665	COG0835	chemotaxis
E4N75_RS05675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N75_RS05680	COG0488	(ABC) transporter
E4N75_RS05690	COG0493	'glutamate synthase
E4N75_RS05690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N75_RS05695	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4N75_RS05735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N75_RS05755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N75_RS05780	COG1002	Type II restriction enzyme, methylase subunits
E4N75_RS05785	COG1002	Type II restriction enzyme, methylase subunits
E4N75_RS05790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N75_RS05795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4N75_RS05800	COG0509	glycine decarboxylation via glycine cleavage system
E4N75_RS05805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4N75_RS05815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4N75_RS05850	COG3052	prosthetic group binding
E4N75_RS05855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N75_RS05855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N75_RS05855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N75_RS05860	COG0237	dephospho-CoA kinase activity
E4N75_RS05870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N75_RS05875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N75_RS05890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N75_RS05905	COG1122	ATPase activity
E4N75_RS05910	COG1268	BioY protein
E4N75_RS05935	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N75_RS05965	COG1136	(ABC) transporter
E4N75_RS05970	COG0577	efflux transmembrane transporter activity
E4N75_RS05990	COG3470	protein probably involved in high-affinity Fe2 transport
E4N75_RS05995	COG0672	)-iron permease
E4N75_RS06000	COG0672	)-iron permease
E4N75_RS06010	COG1136	(ABC) transporter
E4N75_RS06020	COG1760	l-serine dehydratase
E4N75_RS06025	COG1760	l-serine dehydratase
E4N75_RS06035	COG0254	rRNA binding
E4N75_RS06040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N75_RS06055	COG0574	Belongs to the PEP-utilizing enzyme family
E4N75_RS06055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N75_RS06065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4N75_RS06075	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N75_RS06090	COG1196	nuclear chromosome segregation
E4N75_RS06100	COG2201	protein-glutamate methylesterase activity
E4N75_RS06110	COG0835	chemotaxis
E4N75_RS06115	COG2198	Histidine kinase
E4N75_RS06115	COG0643	Histidine kinase
E4N75_RS06130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N75_RS06135	COG0217	transcriptional regulatory protein
E4N75_RS06170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N75_RS06175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N75_RS06185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N75_RS06185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N75_RS06200	COG0802	atpase or kinase
E4N75_RS06210	COG3437	response regulator, receiver
E4N75_RS06210	COG2770	Histidine kinase
E4N75_RS06215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N75_RS06220	COG0681	Belongs to the peptidase S26 family
E4N75_RS06225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N75_RS06250	COG0330	HflC and HflK could
E4N75_RS06255	COG0330	HflC and HflK could
E4N75_RS06265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N75_RS06295	COG1739	Uncharacterized protein family UPF0029
E4N75_RS06320	COG2604	Protein of unknown function DUF115
E4N75_RS06330	COG0768	penicillin binding
E4N75_RS06335	COG0681	Belongs to the peptidase S26 family
E4N75_RS06355	COG0009	L-threonylcarbamoyladenylate synthase
E4N75_RS06400	COG2211	Major facilitator Superfamily
E4N75_RS06400	COG2190	(PTS) system
E4N75_RS06415	COG1193	negative regulation of DNA recombination
E4N75_RS06420	COG1193	negative regulation of DNA recombination
E4N75_RS06425	COG1162	GTPase activity
E4N75_RS06435	COG1132	(ABC) transporter
E4N75_RS06440	COG1132	(ABC) transporter
E4N75_RS06445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N75_RS06460	COG4166	transmembrane transport
E4N75_RS06480	COG0525	valine-tRNA ligase activity
E4N75_RS06485	COG2252	PERMEase
E4N75_RS06510	COG0772	Belongs to the SEDS family
E4N75_RS06515	COG0768	penicillin binding
E4N75_RS06530	COG1077	Cell shape determining protein MreB Mrl
E4N75_RS06550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N75_RS06555	COG0358	DNA primase activity
E4N75_RS06560	COG0606	chelatase, subunit chli
E4N75_RS06575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N75_RS06580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N75_RS06590	COG1164	Oligoendopeptidase f
E4N75_RS06635	COG2375	cellular response to nickel ion
E4N75_RS06635	COG1132	(ABC) transporter
E4N75_RS06645	COG1132	(ABC) transporter
E4N75_RS06825	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E4N75_RS06875	COG2885	chlorophyll binding
E4N75_RS06880	COG0084	hydrolase, TatD family'
E4N75_RS06890	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N75_RS06900	COG0438	transferase activity, transferring glycosyl groups
E4N75_RS06905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N75_RS06915	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4N75_RS06920	COG3880	PFAM UvrB UvrC protein
E4N75_RS06930	COG1136	(ABC) transporter
E4N75_RS06935	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N75_RS06945	COG0552	protein localization to endoplasmic reticulum
E4N75_RS07000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4N75_RS07005	COG4475	Protein of unknown function (DUF436)
E4N75_RS07025	COG0601	transmembrane transport
E4N75_RS07030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_RS07040	COG0444	Belongs to the ABC transporter superfamily
E4N75_RS07045	COG4608	Belongs to the ABC transporter superfamily
E4N75_RS07065	COG0151	Belongs to the GarS family
E4N75_RS07085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N75_RS07090	COG3118	belongs to the thioredoxin family
E4N75_RS07095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N75_RS07100	COG0457	Tetratricopeptide repeat
E4N75_RS07105	COG0037	tRNA processing
E4N75_RS07110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N75_RS07120	COG2088	sporulation resulting in formation of a cellular spore
E4N75_RS07125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N75_RS07150	COG0295	cytidine deaminase activity
E4N75_RS07245	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N75_RS07250	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N75_RS07255	COG3845	ABC transporter
E4N75_RS07260	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N75_RS07265	COG1363	Peptidase, m42
E4N75_RS07270	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N75_RS07285	COG0740	serine-type endopeptidase activity
E4N75_RS07305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N75_RS07320	COG0706	membrane insertase activity
E4N75_RS07325	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N75_RS07335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4N75_RS07345	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N75_RS07350	COG1121	(ABC) transporter
E4N75_RS07355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N75_RS07360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N75_RS07370	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N75_RS07385	COG1157	protein secretion by the type III secretion system
E4N75_RS07390	COG1317	bacterial-type flagellum organization
E4N75_RS07400	COG1766	The M ring may be actively involved in energy transduction
E4N75_RS07405	COG1677	Flagellar hook-basal body complex protein FliE
E4N75_RS07420	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N75_RS07425	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N75_RS07430	COG4974	Belongs to the 'phage' integrase family
E4N75_RS07435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N75_RS07435	COG0551	DNA topoisomerase type I activity
E4N75_RS07440	COG0758	DNA mediated transformation
E4N75_RS07455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N75_RS07470	COG0772	Belongs to the SEDS family
E4N75_RS07475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N75_RS07485	COG0275	rRNA processing
E4N75_RS07490	COG2001	Belongs to the MraZ family
E4N75_RS07495	COG1505	serine-type exopeptidase activity
E4N75_RS07535	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4N75_RS07550	COG0495	leucyl-tRNA aminoacylation
E4N75_RS07560	COG0750	zinc metalloprotease
E4N75_RS07565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N75_RS07575	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N75_RS07580	COG0233	cytoplasmic translational termination
E4N75_RS07585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N75_RS07590	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N75_RS07595	COG0424	maF-like protein
E4N75_RS07600	COG1413	lyase activity
E4N75_RS07620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N75_RS07625	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4N75_RS07630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4N75_RS07640	COG0739	heme binding
E4N75_RS07640	COG1196	nuclear chromosome segregation
E4N75_RS07640	COG0741	lytic transglycosylase activity
E4N75_RS07665	COG0668	transmembrane transport
E4N75_RS07680	COG0840	transmembrane signaling receptor activity
E4N75_RS07695	COG4166	transmembrane transport
E4N75_RS07700	COG0601	transmembrane transport
E4N75_RS07705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_RS07710	COG0444	Belongs to the ABC transporter superfamily
E4N75_RS07715	COG4172	Belongs to the ABC transporter superfamily
E4N75_RS07720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N75_RS07740	COG0425	Belongs to the sulfur carrier protein TusA family
E4N75_RS07755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N75_RS07760	COG1126	abc transporter atp-binding protein
E4N75_RS07775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N75_RS07795	COG0601	transmembrane transport
E4N75_RS07800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_RS07805	COG0444	Belongs to the ABC transporter superfamily
E4N75_RS07810	COG4608	Belongs to the ABC transporter superfamily
E4N75_RS07875	COG0534	Mate efflux family protein
E4N75_RS07880	COG0840	transmembrane signaling receptor activity
E4N75_RS07885	COG1757	Na H antiporter
E4N75_RS07890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4N75_RS07895	COG3829	transcription factor binding
E4N75_RS07895	COG3290	protein histidine kinase activity
E4N75_RS07920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N75_RS07925	COG0049	tRNA binding
E4N75_RS07930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4N75_RS07950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4N75_RS07955	COG0626	cystathionine gamma-synthase activity
E4N75_RS07965	COG1757	Na H antiporter
E4N75_RS08015	COG1122	ATPase activity
E4N75_RS08050	COG1770	oligopeptidase
E4N75_RS08055	COG1902	pentaerythritol trinitrate reductase activity
E4N75_RS08055	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N75_RS08070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4N75_RS08080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N75_RS08090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N75_RS08115	COG0598	Magnesium transport protein CorA
E4N75_RS08120	COG0617	tRNA 3'-terminal CCA addition
E4N75_RS08135	COG0071	Belongs to the small heat shock protein (HSP20) family
E4N75_RS08140	COG0571	ribonuclease III activity
E4N75_RS08145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N75_RS08150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N75_RS08165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4N75_RS08185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N75_RS08185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4N75_RS08195	COG1570	exodeoxyribonuclease VII activity
E4N75_RS08200	COG1067	ATP-dependent peptidase activity
E4N75_RS08205	COG1067	ATP-dependent peptidase activity
E4N75_RS08215	COG2703	oxygen carrier activity
E4N75_RS08235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N75_RS08240	COG1722	exodeoxyribonuclease VII activity
E4N75_RS08245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N75_RS08285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N75_RS08295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4N75_RS08300	COG0085	RNA polymerase activity
E4N75_RS08305	COG0222	ribosome binding
E4N75_RS08310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N75_RS08315	COG0081	regulation of translation
E4N75_RS08320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N75_RS08325	COG0250	Participates in transcription elongation, termination and antitermination
E4N75_RS08330	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N75_RS08340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N75_RS08370	COG1652	LysM domain
E4N75_RS08390	COG0326	Molecular chaperone. Has ATPase activity
E4N75_RS08400	COG0210	DNA helicase
E4N75_RS08405	COG1132	(ABC) transporter
E4N75_RS08410	COG1132	(ABC) transporter
E4N75_RS08415	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N75_RS08430	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N75_RS08435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N75_RS08445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N75_RS08450	COG0840	transmembrane signaling receptor activity
E4N75_RS08470	COG3956	TIGRFAM MazG family protein
E4N75_RS08475	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N75_RS08500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N75_RS08520	COG1132	(ABC) transporter
E4N75_RS08525	COG1132	(ABC) transporter
E4N75_RS08530	COG1012	belongs to the aldehyde dehydrogenase family
E4N75_RS08535	COG0357	Ribosomal RNA small subunit methyltransferase G
E4N75_RS08605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N75_RS08625	COG1120	ATPase activity
E4N75_RS08630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N75_RS08635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4N75_RS08645	COG4865	methylaspartate mutase activity
E4N75_RS08650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4N75_RS08665	COG0284	orotidine-5'-phosphate decarboxylase activity
E4N75_RS08685	COG1131	(ABC) transporter
E4N75_RS08690	COG2770	Histidine kinase
E4N75_RS08690	COG2208	phosphoserine phosphatase activity
E4N75_RS08710	COG1126	abc transporter atp-binding protein
E4N75_RS08720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N75_RS08745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4N75_RS08760	COG1272	protein, Hemolysin III
E4N75_RS08765	COG3177	Filamentation induced by cAMP protein fic
E4N75_RS08770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N75_RS08790	COG2378	regulation of single-species biofilm formation
E4N75_RS08825	COG4115	mRNA cleavage
E4N75_RS08835	COG2885	chlorophyll binding
E4N75_RS08840	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N75_RS08840	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N75_RS08840	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N75_RS08840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N75_RS08845	COG0737	Belongs to the 5'-nucleotidase family
E4N75_RS08880	COG0148	phosphopyruvate hydratase activity
E4N75_RS08885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4N75_RS08895	COG2738	Putative neutral zinc metallopeptidase
E4N75_RS08955	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N75_RS08960	COG0671	phosphoesterase, PA-phosphatase related
E4N75_RS08990	COG1475	DNA binding
E4N75_RS09000	COG0739	heme binding
E4N75_RS09005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N75_RS09005	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N75_RS09020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N75_RS09025	COG0549	Belongs to the carbamate kinase family
E4N75_RS09040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4N75_RS09055	COG1362	aminopeptidase activity
E4N75_RS09060	COG0445	tRNA wobble uridine modification
E4N75_RS09065	COG0210	DNA helicase
E4N75_RS09085	COG3604	Transcriptional regulator
E4N75_RS09115	COG1573	uracil-dna glycosylase
E4N75_RS09120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N75_RS09125	COG0196	riboflavin kinase activity
E4N75_RS09130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4N75_RS09135	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N75_RS09140	COG0756	dUTP diphosphatase activity
E4N75_RS09155	COG0564	pseudouridine synthase activity
E4N75_RS09160	COG0156	8-amino-7-oxononanoate synthase activity
E4N75_RS09190	COG1132	(ABC) transporter
E4N75_RS09195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N75_RS09200	COG1329	Transcriptional regulator
E4N75_RS09205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N75_RS09205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N75_RS09210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N75_RS09230	COG0668	transmembrane transport
E4N75_RS09245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N75_RS09250	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N75_RS09255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N75_RS09270	COG0792	nuclease activity
E4N75_RS09285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N75_RS09305	COG1111	helicase
E4N75_RS09305	COG1205	dead DEAH box helicase
E4N75_RS09325	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N75_RS09350	COG0504	CTP synthase activity
E4N75_RS09365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N75_RS09365	COG1747	RNA polymerase binding
E4N75_RS09380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N75_RS09395	COG5377	YqaJ viral recombinase family
E4N75_RS09525	COG0629	single-stranded DNA binding
E4N75_RS09920	COG0330	HflC and HflK could
E4N75_RS09940	COG1129	ABC transporter
E4N75_RS09965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4N75_RS09975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N75_RS09985	COG4608	Belongs to the ABC transporter superfamily
E4N75_RS10000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_RS10005	COG0601	transmembrane transport
E4N75_RS10015	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4N75_RS10020	COG4657	Part of a membrane complex involved in electron transport
E4N75_RS10025	COG4660	Part of a membrane complex involved in electron transport
E4N75_RS10035	COG4658	electron transport chain
E4N75_RS10040	COG4656	Part of a membrane complex involved in electron transport
E4N75_RS10050	COG2304	oxidoreductase activity
E4N75_RS10065	COG0574	Belongs to the PEP-utilizing enzyme family
E4N75_RS10065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N75_RS10075	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N75_RS10085	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E4N75_RS10105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N75_RS10120	COG2197	response regulator
E4N75_RS10145	COG1187	pseudouridine synthase activity
E4N75_RS10150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N75_RS10200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4N75_RS10215	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N75_RS10220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N75_RS10230	COG2226	methyltransferase
E4N75_RS10250	COG1254	Belongs to the acylphosphatase family
E4N75_RS10275	COG0203	ribosomal protein L17
E4N75_RS10280	COG0202	RNA polymerase activity
E4N75_RS10285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N75_RS10290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4N75_RS10295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N75_RS10305	COG0200	Binds to the 23S rRNA
E4N75_RS10310	COG1841	ribosomal large subunit assembly
E4N75_RS10315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N75_RS10320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4N75_RS10325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N75_RS10330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N75_RS10335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4N75_RS10340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N75_RS10345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N75_RS10350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N75_RS10355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N75_RS10360	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N75_RS10365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4N75_RS10370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N75_RS10375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N75_RS10380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4N75_RS10385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N75_RS10390	COG0089	rRNA binding
E4N75_RS10395	COG0088	Forms part of the polypeptide exit tunnel
E4N75_RS10400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N75_RS10405	COG0051	transcription antitermination factor activity, RNA binding
E4N75_RS10410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N75_RS10430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N75_RS10440	COG3706	GGDEF domain
E4N75_RS10460	COG0840	transmembrane signaling receptor activity
E4N75_RS10470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N75_RS10475	COG0564	pseudouridine synthase activity
E4N75_RS10485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N75_RS10490	COG0166	Belongs to the GPI family
E4N75_RS10495	COG1362	aminopeptidase activity
E4N75_RS10500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4N75_RS10505	COG0724	RNA recognition motif
E4N75_RS10510	COG2211	Major facilitator Superfamily
E4N75_RS10555	COG1266	CAAX protease self-immunity
E4N75_RS10565	COG0396	ATPase activity
E4N75_RS10570	COG0719	Fe-S assembly protein
E4N75_RS10580	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N75_RS10600	COG2201	protein-glutamate methylesterase activity
E4N75_RS10620	COG1137	ATPase activity
E4N75_RS10625	COG0193	aminoacyl-tRNA hydrolase activity
E4N75_RS10635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N75_RS10645	COG0601	transmembrane transport
E4N75_RS10650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_RS10655	COG0444	Belongs to the ABC transporter superfamily
E4N75_RS10660	COG4608	Belongs to the ABC transporter superfamily
E4N75_RS10665	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4N75_RS10670	COG1876	peptidase activity
E4N75_RS10690	COG0484	heat shock protein binding
E4N75_RS10695	COG0443	Heat shock 70 kDa protein
E4N75_RS10700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N75_RS10735	COG1120	ATPase activity
E4N75_RS10765	COG0534	Mate efflux family protein
E4N75_RS10795	COG1192	Involved in chromosome partitioning
E4N75_RS10800	COG1475	DNA binding
E4N75_RS10820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N75_RS10825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N75_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
E4N75_RS10845	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N75_RS10870	COG0439	Biotin carboxylase
E4N75_RS10880	COG0825	malonyl-CoA metabolic process
E4N75_RS10885	COG2986	histidine ammonia-lyase
E4N75_RS10900	COG0714	Associated with various cellular activities
E4N75_RS10935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N75_RS10940	COG0154	amidase activity
E4N75_RS10945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N75_RS11075	COG1136	(ABC) transporter
E4N75_RS11215	COG1396	sequence-specific DNA binding
E4N75_RS11225	COG3550	peptidyl-serine autophosphorylation
E4N75_RS11260	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4N75_RS11320	COG1132	(ABC) transporter
E4N75_RS11325	COG1132	(ABC) transporter
E4N75_RS11330	COG0280	phosphate acetyltransferase
E4N75_RS11335	COG0457	Tetratricopeptide repeat
E4N75_RS11340	COG0587	DNA-directed DNA polymerase activity
E4N75_RS11375	COG3177	Filamentation induced by cAMP protein fic
E4N75_RS11385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4N75_RS11385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4N75_RS11390	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N75_RS11400	COG4175	Glycine betaine
E4N75_RS11400	COG3448	diguanylate cyclase activity
E4N75_RS11410	COG2205	protein histidine kinase activity
E4N75_RS11415	COG1136	(ABC) transporter
E4N75_RS11430	COG0095	Lipoate-protein ligase
E4N75_RS11440	COG1131	(ABC) transporter
E4N75_RS11445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4N75_RS11450	COG1122	ATPase activity
E4N75_RS11495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4N75_RS11510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N75_RS11515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N75_RS11545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N75_RS11585	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4N75_RS11600	COG1774	PSP1 C-terminal conserved region
E4N75_RS11605	COG1728	Protein conserved in bacteria
E4N75_RS11615	COG0739	heme binding
E4N75_RS11630	COG0366	Alpha amylase catalytic
E4N75_RS11640	COG1609	Transcriptional regulator
E4N75_RS11645	COG1129	ABC transporter
E4N75_RS11675	COG0543	2 iron, 2 sulfur cluster binding
E4N75_RS11680	COG0784	Response regulator, receiver
E4N75_RS11680	COG3437	response regulator, receiver
E4N75_RS11755	COG3177	Filamentation induced by cAMP protein fic
E4N75_RS11775	COG1129	ABC transporter
E4N75_RS11785	COG1132	(ABC) transporter
E4N75_RS11790	COG1309	transcriptional regulator
E4N75_RS11795	COG3189	MarR family transcriptional regulator
E4N75_RS11810	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N75_RS11815	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N75_RS11820	COG1684	flagellar biosynthetic protein fliR
E4N75_RS11825	COG1987	bacterial-type flagellum assembly
E4N75_RS11860	COG1228	amidohydrolase
E4N75_RS11910	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N75_RS11915	COG0583	DNA-binding transcription factor activity
E4N75_RS11925	COG0747	negative chemotaxis
E4N75_RS11930	COG4608	Belongs to the ABC transporter superfamily
E4N75_RS11935	COG0444	Belongs to the ABC transporter superfamily
E4N75_RS11940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N75_RS11965	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N75_RS11980	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N75_RS12000	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N75_RS12010	COG4143	(ABC) transporter
E4N75_RS12025	COG1373	ATPase (AAA superfamily
E4N75_RS12035	COG1473	amidohydrolase
E4N75_RS12040	COG4585	Histidine kinase
E4N75_RS12045	COG2197	response regulator
E4N75_RS12050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N75_RS12125	COG3093	addiction module antidote protein HigA
E4N75_RS12130	COG3549	Plasmid maintenance system killer
E4N75_RS12140	COG0728	peptidoglycan biosynthetic process
E4N75_RS12145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N75_RS12160	COG3588	fructose-bisphosphate aldolase
E4N75_RS12170	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
E4N75_RS12190	COG0012	GTP binding
E4N75_RS12195	COG0616	signal peptide processing
E4N75_RS12205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E4N75_RS12225	COG5012	cobalamin binding
E4N75_RS12230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N75_RS12235	COG1132	(ABC) transporter
E4N75_RS12240	COG1132	(ABC) transporter
E4N75_RS12250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N75_RS12255	COG0363	glucosamine-6-phosphate deaminase activity
E4N75_RS12265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N75_RS12270	COG0534	Mate efflux family protein
E4N75_RS12275	COG1309	transcriptional regulator
E4N75_RS12280	COG0786	glutamate:sodium symporter activity
E4N75_RS12285	COG0840	transmembrane signaling receptor activity
E4N75_RS12290	COG0840	transmembrane signaling receptor activity
E4N75_RS12295	COG0813	purine-nucleoside phosphorylase activity
E4N75_RS12340	COG5002	protein histidine kinase activity
E4N75_RS12340	COG5001	Diguanylate cyclase
E4N75_RS12345	COG0540	Belongs to the ATCase OTCase family
E4N75_RS12345	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4N75_RS12375	COG3842	ATPase activity
E4N75_RS12380	COG3833	ABC-type maltose transport systems, permease component
E4N75_RS12385	COG1175	transmembrane transport
E4N75_RS12395	COG1418	mRNA catabolic process
E4N75_RS12400	COG0419	ATPase involved in DNA repair
E4N75_RS12405	COG0420	3'-5' exonuclease activity
E4N75_RS12410	COG0840	transmembrane signaling receptor activity
E4N75_RS12410	COG3290	protein histidine kinase activity
E4N75_RS12420	COG1131	(ABC) transporter
E4N75_RS12440	COG0716	FMN binding
E4N75_RS12455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4N75_RS12460	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N75_RS12465	COG0592	DNA-directed DNA polymerase activity
E4N75_RS12470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N75_RS12555	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
E4N75_RS12615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4N75_RS12630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4N75_RS12635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N75_RS12670	COG2184	nucleotidyltransferase activity
E4N75_RS12680	COG0730	response to heat
E4N75_RS12705	COG4208	sulfate ABC transporter
E4N75_RS12710	COG3839	Belongs to the ABC transporter superfamily
E4N75_RS12720	COG0840	transmembrane signaling receptor activity
E4N75_RS12735	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N75_RS12740	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N75_RS12745	COG1674	ftsk spoiiie
E4N75_RS12760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N75_RS12780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4N75_RS12785	COG0534	Mate efflux family protein
E4N75_RS12790	COG0569	domain protein
E4N75_RS12815	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4N75_RS12820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N75_RS12835	COG2235	arginine
E4N75_RS12840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N75_RS12850	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N75_RS12855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N75_RS12860	COG0569	domain protein
E4N75_RS12870	COG1487	ribonuclease activity
E4N75_RS12885	COG0714	Associated with various cellular activities
E4N75_RS12890	COG4536	flavin adenine dinucleotide binding
E4N75_RS12895	COG4536	flavin adenine dinucleotide binding
E4N75_RS12910	COG0514	ATP-dependent DNA helicase (RecQ)
E4N75_RS12920	COG1518	maintenance of DNA repeat elements
E4N75_RS12925	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4N75_RS12940	COG1132	(ABC) transporter
E4N75_RS12945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N75_RS12965	COG3271	cysteine-type peptidase activity
E4N75_RS12965	COG2274	protein secretion by the type I secretion system
E4N75_RS12970	COG1132	(ABC) transporter
E4N75_RS12975	COG0438	transferase activity, transferring glycosyl groups
E4N75_RS12980	COG3842	ATPase activity
E4N75_RS13000	COG3706	GGDEF domain
E4N75_RS13015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N75_RS13020	COG0215	cysteine-tRNA ligase activity
E4N75_RS13035	COG1305	Transglutaminase-like
E4N75_RS13045	COG0569	domain protein
E4N75_RS13050	COG2887	Belongs to the helicase family. UvrD subfamily
E4N75_RS13055	COG1074	ATP-dependent DNA helicase activity
E4N75_RS13060	COG1074	ATP-dependent DNA helicase activity
E4N75_RS13070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N75_RS13135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N75_RS13145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N75_RS13160	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N75_RS13170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N75_RS13185	COG1131	(ABC) transporter
E4N75_RS13200	COG0840	transmembrane signaling receptor activity
E4N75_RS13230	COG1151	hydroxylamine reductase activity
E4N75_RS13250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4N75_RS13255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N75_RS13275	COG1401	restriction endodeoxyribonuclease activity
E4N75_RS13285	COG4946	Tricorn protease homolog
E4N75_RS13285	COG1506	peptidase
E4N75_RS13285	COG0823	Involved in the tonB-independent uptake of proteins
E4N75_RS13290	COG4946	Tricorn protease homolog
E4N75_RS13290	COG1506	peptidase
E4N75_RS13290	COG0823	Involved in the tonB-independent uptake of proteins
E4N75_RS13310	COG1104	cysteine desulfurase activity
E4N75_RS13315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4N75_RS13320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N75_RS13340	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N75_RS13355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N75_RS13365	COG1929	Belongs to the glycerate kinase type-1 family
E4N75_RS13380	COG0494	nUDIX hydrolase
E4N75_RS13385	COG0783	Belongs to the Dps family
E4N75_RS13390	COG0450	alkyl hydroperoxide reductase
E4N75_RS13395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N75_RS13415	COG1363	Peptidase, m42
E4N75_RS13425	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N75_RS13430	COG0423	glycine-tRNA ligase activity
E4N75_RS13450	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N75_RS13560	COG1129	ABC transporter
E4N75_RS13575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N75_RS13615	COG1011	Hydrolase
E4N75_RS13635	COG1132	(ABC) transporter
E4N75_RS13640	COG1132	(ABC) transporter
E4N75_RS13640	COG2375	cellular response to nickel ion
E4N75_RS13675	COG0456	acetyltransferase
E4N75_RS13710	COG1129	ABC transporter
E4N75_RS13785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N75_RS13820	COG1191	sigma factor activity
E4N75_RS13835	COG1419	protein localization to endoplasmic reticulum
E4N75_RS13840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4N75_RS13860	COG1132	(ABC) transporter
E4N75_RS13875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N75_RS13890	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N75_RS13895	COG1360	Flagellar Motor Protein
E4N75_RS13900	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N75_RS13905	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N75_RS13910	COG1776	CheC inhibitor of MCP methylation
E4N75_RS13910	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N75_RS13920	COG1338	Plays a role in the flagellum-specific transport system
E4N75_RS13950	COG4555	ABC transporter
E4N75_RS14000	COG0561	phosphatase activity
E4N75_RS14005	COG4166	transmembrane transport
E4N75_RS14010	COG2423	ornithine cyclodeaminase activity
E4N75_RS14015	COG1196	nuclear chromosome segregation
E4N75_RS14015	COG0739	heme binding
E4N75_RS14015	COG0741	lytic transglycosylase activity
E4N75_RS14020	COG4545	Glutaredoxin-related protein
E4N75_RS14035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4N75_RS14050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N75_RS14050	COG3116	cell division
E4N75_RS14055	COG0084	hydrolase, TatD family'
E4N75_RS14065	COG2199	diguanylate cyclase activity
E4N75_RS14065	COG2203	Gaf domain