locus-tag	class	description
HYB91_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HYB91_RS00015	COG0587	DNA-directed DNA polymerase activity
HYB91_RS00040	COG0840	transmembrane signaling receptor activity
HYB91_RS00045	COG1132	(ABC) transporter
HYB91_RS00050	COG1132	(ABC) transporter
HYB91_RS00085	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HYB91_RS00100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HYB91_RS00105	COG1360	Flagellar Motor Protein
HYB91_RS00110	COG1580	Controls the rotational direction of flagella during chemotaxis
HYB91_RS00115	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYB91_RS00120	COG1776	CheC inhibitor of MCP methylation
HYB91_RS00120	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYB91_RS00130	COG1338	Plays a role in the flagellum-specific transport system
HYB91_RS00140	COG2361	Protein of unknown function DUF86
HYB91_RS00150	COG4166	transmembrane transport
HYB91_RS00155	COG2423	ornithine cyclodeaminase activity
HYB91_RS00160	COG0739	heme binding
HYB91_RS00165	COG4545	Glutaredoxin-related protein
HYB91_RS00180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYB91_RS00205	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HYB91_RS00220	COG0732	type I restriction modification DNA specificity domain
HYB91_RS00225	COG4974	Belongs to the 'phage' integrase family
HYB91_RS00245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYB91_RS00245	COG3116	cell division
HYB91_RS00250	COG0084	hydrolase, TatD family'
HYB91_RS00260	COG1373	ATPase (AAA superfamily
HYB91_RS00265	COG2203	Gaf domain
HYB91_RS00265	COG2199	diguanylate cyclase activity
HYB91_RS00275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYB91_RS00300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYB91_RS00310	COG2239	Acts as a magnesium transporter
HYB91_RS00320	COG0546	phosphoglycolate phosphatase activity
HYB91_RS00340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYB91_RS00380	COG2211	Major facilitator Superfamily
HYB91_RS00430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYB91_RS00430	COG1747	RNA polymerase binding
HYB91_RS00445	COG0504	CTP synthase activity
HYB91_RS00460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYB91_RS00465	COG1419	protein localization to endoplasmic reticulum
HYB91_RS00480	COG1191	sigma factor activity
HYB91_RS00515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYB91_RS00545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYB91_RS00550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYB91_RS00555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYB91_RS00565	COG0516	GMP reductase activity
HYB91_RS00570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYB91_RS00590	COG3437	response regulator, receiver
HYB91_RS00590	COG0784	Response regulator, receiver
HYB91_RS00595	COG1797	cobyrinic acid a,c-diamide synthase activity
HYB91_RS00625	COG1122	ATPase activity
HYB91_RS00630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYB91_RS00635	COG1131	(ABC) transporter
HYB91_RS00645	COG0095	Lipoate-protein ligase
HYB91_RS00650	COG0517	IMP dehydrogenase activity
HYB91_RS00650	COG4175	Glycine betaine
HYB91_RS00660	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYB91_RS00665	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HYB91_RS00665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYB91_RS00675	COG3177	Filamentation induced by cAMP protein fic
HYB91_RS00715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_RS00725	COG0747	negative chemotaxis
HYB91_RS00735	COG1132	(ABC) transporter
HYB91_RS00735	COG2375	cellular response to nickel ion
HYB91_RS00740	COG1132	(ABC) transporter
HYB91_RS00755	COG1129	ABC transporter
HYB91_RS00765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYB91_RS00780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYB91_RS00785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYB91_RS00790	COG1477	protein flavinylation
HYB91_RS00810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYB91_RS00825	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYB91_RS00830	COG0406	alpha-ribazole phosphatase activity
HYB91_RS00840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYB91_RS00850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYB91_RS00860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HYB91_RS00870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYB91_RS00895	COG0724	RNA recognition motif
HYB91_RS00900	COG1054	Belongs to the UPF0176 family
HYB91_RS00905	COG1362	aminopeptidase activity
HYB91_RS00920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYB91_RS00925	COG3290	protein histidine kinase activity
HYB91_RS00925	COG0840	transmembrane signaling receptor activity
HYB91_RS00950	COG3706	GGDEF domain
HYB91_RS00955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYB91_RS00970	COG0564	pseudouridine synthase activity
HYB91_RS00980	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYB91_RS00985	COG0166	Belongs to the GPI family
HYB91_RS00990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYB91_RS00995	COG4443	Transcriptional Coactivator p15 (PC4)
HYB91_RS01000	COG0328	RNA-DNA hybrid ribonuclease activity
HYB91_RS01005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HYB91_RS01010	COG0301	tRNA thio-modification
HYB91_RS01040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYB91_RS01045	COG1121	(ABC) transporter
HYB91_RS01050	COG4988	ABC transporter
HYB91_RS01055	COG1132	(ABC) transporter
HYB91_RS01065	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HYB91_RS01070	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HYB91_RS01075	COG1132	(ABC) transporter
HYB91_RS01100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYB91_RS01150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYB91_RS01185	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HYB91_RS01200	COG2604	Protein of unknown function DUF115
HYB91_RS01235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYB91_RS01260	COG0357	Ribosomal RNA small subunit methyltransferase G
HYB91_RS01265	COG1012	belongs to the aldehyde dehydrogenase family
HYB91_RS01270	COG1132	(ABC) transporter
HYB91_RS01275	COG1132	(ABC) transporter
HYB91_RS01300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYB91_RS01335	COG0840	transmembrane signaling receptor activity
HYB91_RS01350	COG1573	uracil-dna glycosylase
HYB91_RS01355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYB91_RS01360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYB91_RS01410	COG0326	Molecular chaperone. Has ATPase activity
HYB91_RS01420	COG0322	excinuclease ABC activity
HYB91_RS01425	COG1921	L-seryl-tRNASec selenium transferase activity
HYB91_RS01430	COG0549	Belongs to the carbamate kinase family
HYB91_RS01435	COG0534	Mate efflux family protein
HYB91_RS01445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HYB91_RS01455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYB91_RS01470	COG0425	Belongs to the sulfur carrier protein TusA family
HYB91_RS01490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYB91_RS01550	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HYB91_RS01555	COG0666	response to abiotic stimulus
HYB91_RS01560	COG3885	ferrous iron binding
HYB91_RS01560	COG2078	PFAM AMMECR1 domain protein
HYB91_RS01575	COG0281	malic enzyme
HYB91_RS01585	COG2274	protein secretion by the type I secretion system
HYB91_RS01590	COG1363	Peptidase, m42
HYB91_RS01595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYB91_RS01655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYB91_RS01665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYB91_RS01670	COG0250	Participates in transcription elongation, termination and antitermination
HYB91_RS01675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYB91_RS01680	COG0081	regulation of translation
HYB91_RS01685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYB91_RS01690	COG0222	ribosome binding
HYB91_RS01695	COG0085	RNA polymerase activity
HYB91_RS01700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYB91_RS01740	COG0058	SHG alpha-glucan phosphorylase activity
HYB91_RS01745	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYB91_RS01760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYB91_RS01780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYB91_RS01790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYB91_RS01795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYB91_RS01805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYB91_RS01810	COG0706	membrane insertase activity
HYB91_RS01815	COG1847	R3H domain protein
HYB91_RS01825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYB91_RS01835	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HYB91_RS01840	COG0740	serine-type endopeptidase activity
HYB91_RS01855	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYB91_RS01865	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYB91_RS01875	COG4585	Histidine kinase
HYB91_RS01890	COG1131	(ABC) transporter
HYB91_RS01895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HYB91_RS01915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYB91_RS01930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYB91_RS01935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYB91_RS01975	COG2376	Dihydroxyacetone kinase
HYB91_RS01980	COG2376	Dihydroxyacetone kinase
HYB91_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYB91_RS02000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HYB91_RS02005	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HYB91_RS02030	COG1413	lyase activity
HYB91_RS02035	COG0424	maF-like protein
HYB91_RS02040	COG0052	Belongs to the universal ribosomal protein uS2 family
HYB91_RS02045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYB91_RS02050	COG0233	cytoplasmic translational termination
HYB91_RS02055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYB91_RS02060	COG0575	Belongs to the CDS family
HYB91_RS02065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HYB91_RS02070	COG0750	zinc metalloprotease
HYB91_RS02080	COG0495	leucyl-tRNA aminoacylation
HYB91_RS02095	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HYB91_RS02100	COG0210	DNA helicase
HYB91_RS02110	COG2949	membrane
HYB91_RS02140	COG0542	response to heat
HYB91_RS02145	COG1492	cobalamin metabolic process
HYB91_RS02155	COG2197	response regulator
HYB91_RS02160	COG0668	transmembrane transport
HYB91_RS02185	COG0741	lytic transglycosylase activity
HYB91_RS02185	COG0739	heme binding
HYB91_RS02185	COG1196	nuclear chromosome segregation
HYB91_RS02190	COG1272	protein, Hemolysin III
HYB91_RS02205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYB91_RS02225	COG3604	Transcriptional regulator
HYB91_RS02245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYB91_RS02260	COG0792	nuclease activity
HYB91_RS02275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYB91_RS02280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HYB91_RS02285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYB91_RS02300	COG0668	transmembrane transport
HYB91_RS02315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYB91_RS02320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYB91_RS02320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HYB91_RS02325	COG1329	Transcriptional regulator
HYB91_RS02330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYB91_RS02340	COG0545	Peptidyl-prolyl cis-trans isomerase
HYB91_RS02345	COG3956	TIGRFAM MazG family protein
HYB91_RS02360	COG0577	efflux transmembrane transporter activity
HYB91_RS02360	COG1136	(ABC) transporter
HYB91_RS02365	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HYB91_RS02380	COG1639	'signal transduction protein
HYB91_RS02390	COG1639	'signal transduction protein
HYB91_RS02395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYB91_RS02405	COG0101	tRNA pseudouridine synthase activity
HYB91_RS02420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HYB91_RS02425	COG0840	transmembrane signaling receptor activity
HYB91_RS02430	COG1132	(ABC) transporter
HYB91_RS02440	COG0826	peptidase U32
HYB91_RS02445	COG0737	Belongs to the 5'-nucleotidase family
HYB91_RS02475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYB91_RS02500	COG3142	Participates in the control of copper homeostasis
HYB91_RS02535	COG4865	methylaspartate mutase activity
HYB91_RS02550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYB91_RS02555	COG1120	ATPase activity
HYB91_RS02575	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYB91_RS02585	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYB91_RS02605	COG0442	prolyl-tRNA aminoacylation
HYB91_RS02620	COG1879	ABC-type sugar transport system periplasmic component
HYB91_RS02625	COG1129	ABC transporter
HYB91_RS02630	COG4211	Belongs to the binding-protein-dependent transport system permease family
HYB91_RS02645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYB91_RS02665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYB91_RS02670	COG2056	Na+-H+ antiporter family
HYB91_RS02675	COG1757	Na H antiporter
HYB91_RS02685	COG0626	cystathionine gamma-synthase activity
HYB91_RS02690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYB91_RS02705	COG0156	8-amino-7-oxononanoate synthase activity
HYB91_RS02715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYB91_RS02725	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYB91_RS02725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYB91_RS02730	COG0739	heme binding
HYB91_RS02740	COG1475	DNA binding
HYB91_RS02745	COG1022	Amp-dependent synthetase and ligase
HYB91_RS02770	COG0671	phosphoesterase, PA-phosphatase related
HYB91_RS02775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYB91_RS02830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HYB91_RS02840	COG2738	Putative neutral zinc metallopeptidase
HYB91_RS02845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYB91_RS02845	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HYB91_RS02850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYB91_RS02860	COG1129	ABC transporter
HYB91_RS02875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HYB91_RS02880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYB91_RS02890	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HYB91_RS02895	COG1671	Belongs to the UPF0178 family
HYB91_RS02905	COG1388	LysM domain
HYB91_RS02905	COG0741	lytic transglycosylase activity
HYB91_RS02930	COG3681	Belongs to the UPF0597 family
HYB91_RS02935	COG4953	penicillin-binding protein 1C
HYB91_RS02940	COG1770	oligopeptidase
HYB91_RS02970	COG1122	ATPase activity
HYB91_RS03010	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HYB91_RS03055	COG1131	(ABC) transporter
HYB91_RS03075	COG0284	orotidine-5'-phosphate decarboxylase activity
HYB91_RS03080	COG0513	Belongs to the DEAD box helicase family
HYB91_RS03090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYB91_RS03120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYB91_RS03130	COG3876	Protein conserved in bacteria
HYB91_RS03135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYB91_RS03155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYB91_RS03160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYB91_RS03165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYB91_RS03170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYB91_RS03175	COG0484	heat shock protein binding
HYB91_RS03180	COG0528	UMP kinase activity
HYB91_RS03185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HYB91_RS03200	COG0539	negative regulation of cytoplasmic translation
HYB91_RS03205	COG2204	response regulator
HYB91_RS03210	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HYB91_RS03230	COG5001	Diguanylate cyclase
HYB91_RS03235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYB91_RS03260	COG0251	oxidation-reduction process
HYB91_RS03270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYB91_RS03275	COG1722	exodeoxyribonuclease VII activity
HYB91_RS03285	COG1918	ferrous iron import across plasma membrane
HYB91_RS03290	COG1918	ferrous iron import across plasma membrane
HYB91_RS03290	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HYB91_RS03335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYB91_RS03355	COG4166	transmembrane transport
HYB91_RS03385	COG0552	protein localization to endoplasmic reticulum
HYB91_RS03395	COG4591	ABC-type transport system involved in lipoprotein release permease component
HYB91_RS03400	COG1136	(ABC) transporter
HYB91_RS03410	COG3880	PFAM UvrB UvrC protein
HYB91_RS03415	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HYB91_RS03425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYB91_RS03430	COG0438	transferase activity, transferring glycosyl groups
HYB91_RS03440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYB91_RS03450	COG0084	hydrolase, TatD family'
HYB91_RS03455	COG2885	chlorophyll binding
HYB91_RS03520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HYB91_RS03525	COG1132	(ABC) transporter
HYB91_RS03530	COG1132	(ABC) transporter
HYB91_RS03530	COG2375	cellular response to nickel ion
HYB91_RS03540	COG1309	transcriptional regulator
HYB91_RS03555	COG1164	Oligoendopeptidase f
HYB91_RS03560	COG1132	(ABC) transporter
HYB91_RS03565	COG1132	(ABC) transporter
HYB91_RS03590	COG1164	Oligoendopeptidase f
HYB91_RS03595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYB91_RS03600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYB91_RS03615	COG0606	chelatase, subunit chli
HYB91_RS03625	COG2885	chlorophyll binding
HYB91_RS03625	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HYB91_RS03635	COG1199	ATP-dependent helicase activity
HYB91_RS03645	COG0823	Involved in the tonB-independent uptake of proteins
HYB91_RS03660	COG4254	PFAM FecR protein
HYB91_RS03710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYB91_RS03715	COG1286	toxin biosynthetic process
HYB91_RS03720	COG0470	DNA polymerase III
HYB91_RS03725	COG3852	Histidine kinase
HYB91_RS03730	COG2204	response regulator
HYB91_RS03735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HYB91_RS03750	COG0475	glutathione-regulated potassium exporter activity
HYB91_RS03755	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYB91_RS03800	COG1234	tRNA 3'-trailer cleavage
HYB91_RS03805	COG1744	ABC transporter substrate-binding protein PnrA-like
HYB91_RS03810	COG3845	ABC transporter
HYB91_RS03815	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYB91_RS03820	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYB91_RS03850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYB91_RS03905	COG0295	cytidine deaminase activity
HYB91_RS03940	COG1047	Peptidyl-prolyl cis-trans
HYB91_RS03960	COG0731	radical SAM domain protein
HYB91_RS03970	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HYB91_RS03975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYB91_RS03980	COG1979	alcohol dehydrogenase
HYB91_RS03985	COG2255	four-way junction helicase activity
HYB91_RS03995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HYB91_RS04000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYB91_RS04015	COG0736	holo-[acyl-carrier-protein] synthase activity
HYB91_RS04030	COG1725	Transcriptional regulator
HYB91_RS04035	COG0653	protein targeting
HYB91_RS04040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYB91_RS04045	COG0138	bifunctional purine biosynthesis protein purh
HYB91_RS04050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYB91_RS04055	COG2878	Part of a membrane complex involved in electron transport
HYB91_RS04060	COG0481	GTPase activity
HYB91_RS04070	COG1114	Component of the transport system for branched-chain amino acids
HYB91_RS04085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYB91_RS04100	COG2723	6-phospho-beta-galactosidase activity
HYB91_RS04115	COG0488	(ABC) transporter
HYB91_RS04125	COG0793	Belongs to the peptidase S41A family
HYB91_RS04200	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HYB91_RS04205	COG0632	four-way junction helicase activity
HYB91_RS04255	COG1136	(ABC) transporter
HYB91_RS04260	COG1136	(ABC) transporter
HYB91_RS04260	COG0577	efflux transmembrane transporter activity
HYB91_RS04550	COG2226	methyltransferase
HYB91_RS04565	COG1418	mRNA catabolic process
HYB91_RS04590	COG2033	superoxide reductase activity
HYB91_RS04595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYB91_RS04600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYB91_RS04610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYB91_RS04615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYB91_RS04630	COG0799	negative regulation of ribosome biogenesis
HYB91_RS04635	COG2059	Chromate
HYB91_RS04675	COG0739	heme binding
HYB91_RS04685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYB91_RS04695	COG0708	Exodeoxyribonuclease III
HYB91_RS04700	COG0024	Methionine aminopeptidase
HYB91_RS04715	COG3250	beta-galactosidase activity
HYB91_RS04730	COG1233	COG1233 Phytoene dehydrogenase and related
HYB91_RS04735	COG1017	nitric oxide dioxygenase activity
HYB91_RS04735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYB91_RS04755	COG0617	tRNA 3'-terminal CCA addition
HYB91_RS04775	COG0519	Catalyzes the synthesis of GMP from XMP
HYB91_RS04790	COG0126	phosphoglycerate kinase activity
HYB91_RS04795	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYB91_RS04815	COG0268	Binds directly to 16S ribosomal RNA
HYB91_RS04820	COG0776	regulation of translation
HYB91_RS04825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HYB91_RS04835	COG1058	Belongs to the CinA family
HYB91_RS04835	COG1546	Belongs to the CinA family
HYB91_RS04880	COG0588	phosphoglycerate mutase activity
HYB91_RS04910	COG1131	(ABC) transporter
HYB91_RS04920	COG0457	Tetratricopeptide repeat
HYB91_RS04925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYB91_RS04930	COG2203	Gaf domain
HYB91_RS04930	COG3706	GGDEF domain
HYB91_RS04930	COG4251	negative regulation of phosphorylation
HYB91_RS04930	COG5001	Diguanylate cyclase
HYB91_RS04935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYB91_RS04940	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HYB91_RS04945	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HYB91_RS04950	COG1394	ATPase activity, coupled to movement of substances
HYB91_RS04955	COG1269	ATP hydrolysis coupled proton transport
HYB91_RS04965	COG0360	Binds together with S18 to 16S ribosomal RNA
HYB91_RS04970	COG0629	single-stranded DNA binding
HYB91_RS04975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYB91_RS04980	COG0359	binds to the 23S rRNA
HYB91_RS04990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYB91_RS04995	COG0740	serine-type endopeptidase activity
HYB91_RS05000	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYB91_RS05020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYB91_RS05030	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HYB91_RS05050	COG0305	Participates in initiation and elongation during chromosome replication
HYB91_RS05065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYB91_RS05070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYB91_RS05075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYB91_RS05095	COG1132	(ABC) transporter
HYB91_RS05100	COG1132	(ABC) transporter
HYB91_RS05105	COG1268	BioY protein
HYB91_RS05110	COG1122	ATPase activity
HYB91_RS05135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYB91_RS05150	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HYB91_RS05155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYB91_RS05165	COG0237	dephospho-CoA kinase activity
HYB91_RS05170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYB91_RS05170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYB91_RS05170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYB91_RS05190	COG3052	prosthetic group binding
HYB91_RS05225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYB91_RS05235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYB91_RS05240	COG0509	glycine decarboxylation via glycine cleavage system
HYB91_RS05245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYB91_RS05250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYB91_RS05255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYB91_RS05275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYB91_RS05325	COG0789	Transcriptional regulator
HYB91_RS05330	COG4221	oxidoreductase activity
HYB91_RS05355	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYB91_RS05380	COG1129	ABC transporter
HYB91_RS05390	COG2375	cellular response to nickel ion
HYB91_RS05390	COG1132	(ABC) transporter
HYB91_RS05395	COG1132	(ABC) transporter
HYB91_RS05400	COG1129	ABC transporter
HYB91_RS05405	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HYB91_RS05415	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HYB91_RS05420	COG0493	'glutamate synthase
HYB91_RS05420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYB91_RS05430	COG0488	(ABC) transporter
HYB91_RS05435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYB91_RS05445	COG0835	chemotaxis
HYB91_RS05455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYB91_RS05475	COG0297	glycogen (starch) synthase activity
HYB91_RS05480	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
HYB91_RS05485	COG2982	Protein involved in outer membrane biogenesis
HYB91_RS05505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYB91_RS05510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYB91_RS05580	COG0095	Lipoate-protein ligase
HYB91_RS05585	COG0205	6-phosphofructokinase activity
HYB91_RS05590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYB91_RS05595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYB91_RS05600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYB91_RS05620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYB91_RS05635	COG0727	PFAM Uncharacterised protein family (UPF0153)
HYB91_RS05655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYB91_RS05660	COG0142	geranyltranstransferase activity
HYB91_RS05670	COG1692	metallophosphoesterase
HYB91_RS05690	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HYB91_RS05720	COG1136	(ABC) transporter
HYB91_RS05725	COG0577	efflux transmembrane transporter activity
HYB91_RS05725	COG1136	(ABC) transporter
HYB91_RS05740	COG3470	protein probably involved in high-affinity Fe2 transport
HYB91_RS05745	COG0672	)-iron permease
HYB91_RS05750	COG1136	(ABC) transporter
HYB91_RS05760	COG1760	l-serine dehydratase
HYB91_RS05765	COG1760	l-serine dehydratase
HYB91_RS05775	COG0254	rRNA binding
HYB91_RS05780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HYB91_RS05795	COG0574	Belongs to the PEP-utilizing enzyme family
HYB91_RS05795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYB91_RS05805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYB91_RS05810	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYB91_RS05820	COG1196	nuclear chromosome segregation
HYB91_RS05830	COG2201	protein-glutamate methylesterase activity
HYB91_RS05840	COG0835	chemotaxis
HYB91_RS05860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYB91_RS05865	COG0217	transcriptional regulatory protein
HYB91_RS05915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYB91_RS05920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYB91_RS05930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HYB91_RS05930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HYB91_RS05945	COG0802	atpase or kinase
HYB91_RS05955	COG3437	response regulator, receiver
HYB91_RS05960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYB91_RS05970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYB91_RS05980	COG0009	L-threonylcarbamoyladenylate synthase
HYB91_RS06015	COG1136	(ABC) transporter
HYB91_RS06025	COG3850	Histidine kinase
HYB91_RS06025	COG5002	protein histidine kinase activity
HYB91_RS06030	COG0745	RESPONSE REGULATOR receiver
HYB91_RS06040	COG2190	(PTS) system
HYB91_RS06040	COG2211	Major facilitator Superfamily
HYB91_RS06055	COG1193	negative regulation of DNA recombination
HYB91_RS06060	COG1162	GTPase activity
HYB91_RS06070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYB91_RS06085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HYB91_RS06095	COG0124	histidyl-tRNA synthetase
HYB91_RS06110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYB91_RS06115	COG0438	transferase activity, transferring glycosyl groups
HYB91_RS06125	COG0706	membrane insertase activity
HYB91_RS06130	COG1215	transferase activity, transferring glycosyl groups
HYB91_RS06130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYB91_RS06135	COG1216	Glycosyl transferase, family 2
HYB91_RS06135	COG1442	glycosyl transferase family 8
HYB91_RS06145	COG0438	transferase activity, transferring glycosyl groups
HYB91_RS06150	COG0463	Glycosyl transferase, family 2
HYB91_RS06155	COG0463	Glycosyl transferase, family 2
HYB91_RS06165	COG0438	transferase activity, transferring glycosyl groups
HYB91_RS06190	COG1215	transferase activity, transferring glycosyl groups
HYB91_RS06190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYB91_RS06195	COG1216	Glycosyl transferase, family 2
HYB91_RS06205	COG2423	ornithine cyclodeaminase activity
HYB91_RS06230	COG0028	Belongs to the TPP enzyme family
HYB91_RS06230	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HYB91_RS06240	COG0475	glutathione-regulated potassium exporter activity
HYB91_RS06265	COG1078	dGTPase activity
HYB91_RS06275	COG0047	phosphoribosylformylglycinamidine synthase activity
HYB91_RS06285	COG0488	(ABC) transporter
HYB91_RS06300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYB91_RS06300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYB91_RS06305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYB91_RS06340	COG4658	electron transport chain
HYB91_RS06345	COG4656	Part of a membrane complex involved in electron transport
HYB91_RS06360	COG0564	pseudouridine synthase activity
HYB91_RS06370	COG2217	Heavy metal translocating P-type atpase
HYB91_RS06375	COG0640	Transcriptional regulator
HYB91_RS06380	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HYB91_RS06415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYB91_RS06435	COG0557	exoribonuclease II activity
HYB91_RS06440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HYB91_RS06440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYB91_RS06445	COG0556	nucleotide-excision repair
HYB91_RS06455	COG0346	lactoylglutathione lyase activity
HYB91_RS06460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYB91_RS06470	COG0525	valine-tRNA ligase activity
HYB91_RS06495	COG2252	PERMEase
HYB91_RS06520	COG0772	Belongs to the SEDS family
HYB91_RS06525	COG0768	penicillin binding
HYB91_RS06540	COG1077	Cell shape determining protein MreB Mrl
HYB91_RS06560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYB91_RS06565	COG0358	DNA primase activity
HYB91_RS06575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYB91_RS06580	COG0457	Tetratricopeptide repeat
HYB91_RS06585	COG0037	tRNA processing
HYB91_RS06590	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYB91_RS06600	COG2088	sporulation resulting in formation of a cellular spore
HYB91_RS06605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYB91_RS06630	COG0330	HflC and HflK could
HYB91_RS06635	COG0330	HflC and HflK could
HYB91_RS06645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYB91_RS06675	COG1739	Uncharacterized protein family UPF0029
HYB91_RS06700	COG2604	Protein of unknown function DUF115
HYB91_RS06705	COG0768	penicillin binding
HYB91_RS06715	COG0433	COG0433 Predicted ATPase
HYB91_RS06725	COG0312	modulator of DNA gyrase
HYB91_RS06730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HYB91_RS06760	COG0497	DNA recombination
HYB91_RS06780	COG0791	NLP P60 protein
HYB91_RS06780	COG1388	LysM domain
HYB91_RS06790	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HYB91_RS06795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYB91_RS06800	COG0312	modulator of DNA gyrase
HYB91_RS06835	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYB91_RS06840	COG0840	transmembrane signaling receptor activity
HYB91_RS06880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYB91_RS06885	COG4475	Protein of unknown function (DUF436)
HYB91_RS06890	COG3421	Type III restriction
HYB91_RS06895	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HYB91_RS06915	COG0601	transmembrane transport
HYB91_RS06920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_RS06930	COG0444	Belongs to the ABC transporter superfamily
HYB91_RS06935	COG4608	Belongs to the ABC transporter superfamily
HYB91_RS06970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYB91_RS06975	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYB91_RS06980	COG3118	belongs to the thioredoxin family
HYB91_RS06990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYB91_RS06995	COG4750	Nucleotidyl transferase
HYB91_RS07000	COG1115	amino acid carrier protein
HYB91_RS07035	COG1193	negative regulation of DNA recombination
HYB91_RS07100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYB91_RS07105	COG1480	7TM receptor with intracellular HD hydrolase
HYB91_RS07110	COG1702	phosphate starvation-inducible protein PhoH
HYB91_RS07125	COG0149	triose-phosphate isomerase activity
HYB91_RS07150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYB91_RS07165	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYB91_RS07170	COG1121	(ABC) transporter
HYB91_RS07175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYB91_RS07180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYB91_RS07205	COG1157	protein secretion by the type III secretion system
HYB91_RS07210	COG1317	bacterial-type flagellum organization
HYB91_RS07220	COG1766	The M ring may be actively involved in energy transduction
HYB91_RS07225	COG1677	Flagellar hook-basal body complex protein FliE
HYB91_RS07240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HYB91_RS07245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HYB91_RS07250	COG4974	Belongs to the 'phage' integrase family
HYB91_RS07255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYB91_RS07255	COG0551	DNA topoisomerase type I activity
HYB91_RS07260	COG0758	DNA mediated transformation
HYB91_RS07270	COG4974	Belongs to the 'phage' integrase family
HYB91_RS07275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYB91_RS07290	COG0772	Belongs to the SEDS family
HYB91_RS07295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYB91_RS07305	COG0275	rRNA processing
HYB91_RS07310	COG2001	Belongs to the MraZ family
HYB91_RS07315	COG1505	serine-type exopeptidase activity
HYB91_RS07355	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HYB91_RS07365	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HYB91_RS07385	COG1120	ATPase activity
HYB91_RS07390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYB91_RS07395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYB91_RS07400	COG1846	Transcriptional regulator
HYB91_RS07405	COG0500	methyltransferase
HYB91_RS07415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYB91_RS07420	COG1120	ATPase activity
HYB91_RS07430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYB91_RS07435	COG0459	protein refolding
HYB91_RS07450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYB91_RS07460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYB91_RS07500	COG1366	Belongs to the anti-sigma-factor antagonist family
HYB91_RS07520	COG3033	Beta-eliminating lyase
HYB91_RS07545	COG0563	adenylate kinase activity
HYB91_RS07565	COG0779	Required for maturation of 30S ribosomal subunits
HYB91_RS07575	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYB91_RS07580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYB91_RS07585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYB91_RS07625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYB91_RS07630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYB91_RS07640	COG3330	Domain of unknown function (DUF4912)
HYB91_RS07655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYB91_RS07665	COG3706	GGDEF domain
HYB91_RS07670	COG1102	Psort location Cytoplasmic, score
HYB91_RS07675	COG1561	YicC-like family, N-terminal region
HYB91_RS07690	COG0564	pseudouridine synthase activity
HYB91_RS07705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYB91_RS07710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYB91_RS07715	COG0426	domain, Protein
HYB91_RS07715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYB91_RS07725	COG4608	Belongs to the ABC transporter superfamily
HYB91_RS07730	COG0444	Belongs to the ABC transporter superfamily
HYB91_RS07735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_RS07755	COG0601	transmembrane transport
HYB91_RS07760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_RS07765	COG0444	Belongs to the ABC transporter superfamily
HYB91_RS07770	COG4608	Belongs to the ABC transporter superfamily
HYB91_RS07780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYB91_RS07780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYB91_RS07820	COG0534	Mate efflux family protein
HYB91_RS07825	COG0840	transmembrane signaling receptor activity
HYB91_RS07850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYB91_RS07855	COG0049	tRNA binding
HYB91_RS07860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYB91_RS07870	COG2832	Protein of unknown function (DUF454)
HYB91_RS07885	COG0756	dUTP diphosphatase activity
HYB91_RS07890	COG1185	polyribonucleotide nucleotidyltransferase activity
HYB91_RS07895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYB91_RS07900	COG0196	riboflavin kinase activity
HYB91_RS07925	COG0598	Magnesium transport protein CorA
HYB91_RS07930	COG0617	tRNA 3'-terminal CCA addition
HYB91_RS07945	COG0071	Belongs to the small heat shock protein (HSP20) family
HYB91_RS07950	COG0571	ribonuclease III activity
HYB91_RS07955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYB91_RS07960	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYB91_RS07970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYB91_RS07990	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HYB91_RS07990	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HYB91_RS08005	COG1067	ATP-dependent peptidase activity
HYB91_RS08015	COG2703	oxygen carrier activity
HYB91_RS08020	COG2183	response to ionizing radiation
HYB91_RS08030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYB91_RS08040	COG3951	Flagellar rod assembly protein muramidase FlgJ
HYB91_RS08050	COG4786	Flagellar basal body rod
HYB91_RS08070	COG2084	Dehydrogenase
HYB91_RS08075	COG2116	formate transmembrane transporter activity
HYB91_RS08085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYB91_RS08105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYB91_RS08115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYB91_RS08120	COG4166	transmembrane transport
HYB91_RS08125	COG4608	Belongs to the ABC transporter superfamily
HYB91_RS08130	COG0444	Belongs to the ABC transporter superfamily
HYB91_RS08135	COG4166	transmembrane transport
HYB91_RS08140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_RS08145	COG4174	ABC transporter (Permease)
HYB91_RS08150	COG4166	transmembrane transport
HYB91_RS08165	COG0017	Asparaginyl-tRNA synthetase
HYB91_RS08170	COG1686	Belongs to the peptidase S11 family
HYB91_RS08175	COG2003	Belongs to the UPF0758 family
HYB91_RS08180	COG1040	competence protein
HYB91_RS08185	COG0018	arginyl-trna synthetase
HYB91_RS08200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYB91_RS08210	COG0084	hydrolase, TatD family'
HYB91_RS08215	COG1692	metallophosphoesterase
HYB91_RS08225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYB91_RS08235	COG0484	heat shock protein binding
HYB91_RS08240	COG2089	acid synthase
HYB91_RS08245	COG5341	Protein conserved in bacteria
HYB91_RS08250	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYB91_RS08255	COG0584	glycerophosphoryl diester phosphodiesterase
HYB91_RS08260	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HYB91_RS08265	COG1704	LemA family
HYB91_RS08270	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYB91_RS08275	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYB91_RS08280	COG3845	ABC transporter
HYB91_RS08285	COG1744	ABC transporter substrate-binding protein PnrA-like
HYB91_RS08295	COG0148	phosphopyruvate hydratase activity
HYB91_RS08310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYB91_RS08325	COG0318	PFAM AMP-dependent synthetase and ligase
HYB91_RS08330	COG0791	NLP P60 protein
HYB91_RS08340	COG3735	TraB family
HYB91_RS08345	COG0116	Belongs to the methyltransferase superfamily
HYB91_RS08350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYB91_RS08355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYB91_RS08360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYB91_RS08370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYB91_RS08375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYB91_RS08380	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HYB91_RS08395	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYB91_RS08400	COG2375	cellular response to nickel ion
HYB91_RS08400	COG1132	(ABC) transporter
HYB91_RS08405	COG1132	(ABC) transporter
HYB91_RS08410	COG1132	(ABC) transporter
HYB91_RS08415	COG1132	(ABC) transporter
HYB91_RS08425	COG0433	COG0433 Predicted ATPase
HYB91_RS08445	COG1132	(ABC) transporter
HYB91_RS08460	COG1132	(ABC) transporter
HYB91_RS08485	COG1129	ABC transporter
HYB91_RS08495	COG0210	DNA helicase
HYB91_RS08510	COG1129	ABC transporter
HYB91_RS08525	COG1132	(ABC) transporter
HYB91_RS08530	COG1132	(ABC) transporter
HYB91_RS08530	COG2375	cellular response to nickel ion
HYB91_RS08535	COG2207	Transcriptional regulator
HYB91_RS08545	COG4555	ABC transporter
HYB91_RS08555	COG2378	regulation of single-species biofilm formation
HYB91_RS08575	COG0335	large ribosomal subunit rRNA binding
HYB91_RS08580	COG0336	Belongs to the RNA methyltransferase TrmD family
HYB91_RS08585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYB91_RS08590	COG1837	Belongs to the UPF0109 family
HYB91_RS08595	COG0228	four-way junction DNA binding
HYB91_RS08620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYB91_RS08625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYB91_RS08630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYB91_RS08635	COG0737	Belongs to the 5'-nucleotidase family
HYB91_RS08665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYB91_RS08670	COG1285	pathogenesis
HYB91_RS08690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYB91_RS08695	COG1187	pseudouridine synthase activity
HYB91_RS08720	COG2197	response regulator
HYB91_RS08725	COG2137	regulation of response to DNA damage stimulus
HYB91_RS08735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYB91_RS08760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYB91_RS08770	COG0574	Belongs to the PEP-utilizing enzyme family
HYB91_RS08770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYB91_RS08785	COG2304	oxidoreductase activity
HYB91_RS08795	COG1054	Belongs to the UPF0176 family
HYB91_RS08800	COG4656	Part of a membrane complex involved in electron transport
HYB91_RS08805	COG4658	electron transport chain
HYB91_RS08810	COG4659	FMN binding
HYB91_RS08815	COG4660	Part of a membrane complex involved in electron transport
HYB91_RS08820	COG4657	Part of a membrane complex involved in electron transport
HYB91_RS08825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYB91_RS08840	COG1362	aminopeptidase activity
HYB91_RS08845	COG0445	tRNA wobble uridine modification
HYB91_RS08850	COG3422	double-strand break repair
HYB91_RS08855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYB91_RS08860	COG2340	Cysteine-rich secretory protein family
HYB91_RS08865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYB91_RS08880	COG1132	(ABC) transporter
HYB91_RS08890	COG2274	protein secretion by the type I secretion system
HYB91_RS08960	COG1690	Belongs to the RtcB family
HYB91_RS08970	COG2910	NAD(P)H-binding
HYB91_RS08975	COG1959	2 iron, 2 sulfur cluster binding
HYB91_RS08985	COG0584	glycerophosphoryl diester phosphodiesterase
HYB91_RS08995	COG1254	Belongs to the acylphosphatase family
HYB91_RS09020	COG0203	ribosomal protein L17
HYB91_RS09025	COG0202	RNA polymerase activity
HYB91_RS09030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYB91_RS09035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYB91_RS09040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYB91_RS09050	COG0200	Binds to the 23S rRNA
HYB91_RS09055	COG1841	ribosomal large subunit assembly
HYB91_RS09060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYB91_RS09065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYB91_RS09070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYB91_RS09075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYB91_RS09080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYB91_RS09085	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYB91_RS09090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYB91_RS09095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYB91_RS09100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYB91_RS09105	COG0255	Belongs to the universal ribosomal protein uL29 family
HYB91_RS09110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYB91_RS09115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYB91_RS09120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYB91_RS09125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYB91_RS09130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYB91_RS09135	COG0089	rRNA binding
HYB91_RS09140	COG0088	Forms part of the polypeptide exit tunnel
HYB91_RS09145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYB91_RS09150	COG0051	transcription antitermination factor activity, RNA binding
HYB91_RS09155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYB91_RS09185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYB91_RS09190	COG1120	ATPase activity
HYB91_RS09195	COG1757	Na H antiporter
HYB91_RS09210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYB91_RS09220	COG3118	belongs to the thioredoxin family
HYB91_RS09270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYB91_RS09290	COG1086	Polysaccharide biosynthesis protein
HYB91_RS09330	COG0330	HflC and HflK could
HYB91_RS09345	COG1131	(ABC) transporter
HYB91_RS09385	COG1131	(ABC) transporter
HYB91_RS09390	COG0351	phosphomethylpyrimidine kinase
HYB91_RS09400	COG0482	sulfurtransferase activity
HYB91_RS09415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYB91_RS09420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYB91_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
HYB91_RS09430	COG0629	single-stranded DNA binding
HYB91_RS09435	COG1862	Preprotein translocase
HYB91_RS09440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYB91_RS09445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYB91_RS09450	COG1104	cysteine desulfurase activity
HYB91_RS09460	COG0425	Belongs to the sulfur carrier protein TusA family
HYB91_RS09505	COG0484	heat shock protein binding
HYB91_RS09520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYB91_RS09535	COG0719	Fe-S assembly protein
HYB91_RS09540	COG0396	ATPase activity
HYB91_RS09545	COG0674	pyruvate-flavodoxin oxidoreductase activity
HYB91_RS09545	COG1013	pyruvate-flavodoxin oxidoreductase activity
HYB91_RS09545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HYB91_RS09545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HYB91_RS09550	COG2885	chlorophyll binding
HYB91_RS09560	COG4115	mRNA cleavage
HYB91_RS09585	COG2378	regulation of single-species biofilm formation
HYB91_RS09600	COG1136	(ABC) transporter
HYB91_RS09605	COG5002	protein histidine kinase activity
HYB91_RS09615	COG1473	amidohydrolase
HYB91_RS09630	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HYB91_RS09650	COG2201	protein-glutamate methylesterase activity
HYB91_RS09670	COG1137	ATPase activity
HYB91_RS09675	COG0193	aminoacyl-tRNA hydrolase activity
HYB91_RS09685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYB91_RS09695	COG0601	transmembrane transport
HYB91_RS09700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_RS09705	COG0444	Belongs to the ABC transporter superfamily
HYB91_RS09710	COG4608	Belongs to the ABC transporter superfamily
HYB91_RS09720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HYB91_RS09745	COG0484	heat shock protein binding
HYB91_RS09750	COG0443	Heat shock 70 kDa protein
HYB91_RS09755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYB91_RS09780	COG1120	ATPase activity
HYB91_RS09805	COG0534	Mate efflux family protein
HYB91_RS09835	COG1192	Involved in chromosome partitioning
HYB91_RS09840	COG1475	DNA binding
HYB91_RS09860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYB91_RS09865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYB91_RS09870	COG1028	Short-chain dehydrogenase reductase Sdr
HYB91_RS09885	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HYB91_RS09915	COG0439	Biotin carboxylase
HYB91_RS09920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYB91_RS09925	COG0825	malonyl-CoA metabolic process
HYB91_RS09930	COG2986	histidine ammonia-lyase
HYB91_RS09945	COG0701	Predicted permease
HYB91_RS09950	COG3689	TIGRFAM TIGR03943 family protein
HYB91_RS09955	COG0714	Associated with various cellular activities
HYB91_RS09990	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYB91_RS09995	COG0154	amidase activity
HYB91_RS10000	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYB91_RS10160	COG1136	(ABC) transporter
HYB91_RS10310	COG3041	Addiction module toxin RelE StbE family
HYB91_RS10355	COG1396	sequence-specific DNA binding
HYB91_RS10365	COG3550	peptidyl-serine autophosphorylation
HYB91_RS10390	COG4555	ABC transporter
HYB91_RS10430	COG1151	hydroxylamine reductase activity
HYB91_RS10445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HYB91_RS10450	COG0577	efflux transmembrane transporter activity
HYB91_RS10450	COG1136	(ABC) transporter
HYB91_RS10505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYB91_RS10540	COG0813	purine-nucleoside phosphorylase activity
HYB91_RS10560	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HYB91_RS10565	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYB91_RS10575	COG2235	arginine
HYB91_RS10580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYB91_RS10590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYB91_RS10610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HYB91_RS10645	COG0343	queuine tRNA-ribosyltransferase activity
HYB91_RS10655	COG1381	Involved in DNA repair and RecF pathway recombination
HYB91_RS10665	COG0514	ATP-dependent DNA helicase (RecQ)
HYB91_RS10670	COG1592	Rubrerythrin
HYB91_RS10735	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HYB91_RS10740	COG0501	Belongs to the peptidase M48B family
HYB91_RS10750	COG0543	2 iron, 2 sulfur cluster binding
HYB91_RS10780	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HYB91_RS10795	COG0747	negative chemotaxis
HYB91_RS10800	COG4608	Belongs to the ABC transporter superfamily
HYB91_RS10805	COG0444	Belongs to the ABC transporter superfamily
HYB91_RS10810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYB91_RS10825	COG1840	ABC-type Fe3 transport system, periplasmic component
HYB91_RS10870	COG3842	ATPase activity
HYB91_RS10875	COG0438	transferase activity, transferring glycosyl groups
HYB91_RS10885	COG2274	protein secretion by the type I secretion system
HYB91_RS10885	COG3271	cysteine-type peptidase activity
HYB91_RS10905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYB91_RS10915	COG0786	glutamate:sodium symporter activity
HYB91_RS10920	COG1132	(ABC) transporter
HYB91_RS10925	COG1132	(ABC) transporter
HYB91_RS10945	COG0583	DNA-binding transcription factor activity
HYB91_RS10950	COG0656	L-ascorbic acid biosynthetic process
HYB91_RS10995	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYB91_RS11010	COG0698	ribose 5-phosphate isomerase
HYB91_RS11015	COG0039	L-malate dehydrogenase activity
HYB91_RS11020	COG0534	Mate efflux family protein
HYB91_RS11025	COG0574	Belongs to the PEP-utilizing enzyme family
HYB91_RS11025	COG3848	Pyruvate phosphate dikinase
HYB91_RS11030	COG1309	transcriptional regulator
HYB91_RS11035	COG0840	transmembrane signaling receptor activity
HYB91_RS11055	COG0728	peptidoglycan biosynthetic process
HYB91_RS11060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYB91_RS11065	COG3588	fructose-bisphosphate aldolase
HYB91_RS11070	COG1309	transcriptional regulator
HYB91_RS11085	COG0363	glucosamine-6-phosphate deaminase activity
HYB91_RS11090	COG0628	permease
HYB91_RS11095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYB91_RS11105	COG0534	Mate efflux family protein
HYB91_RS11110	COG1309	transcriptional regulator
HYB91_RS11120	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HYB91_RS11125	COG1518	maintenance of DNA repeat elements
HYB91_RS11130	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HYB91_RS11135	COG0514	ATP-dependent DNA helicase (RecQ)
HYB91_RS11160	COG4536	flavin adenine dinucleotide binding
HYB91_RS11165	COG4536	flavin adenine dinucleotide binding
HYB91_RS11170	COG0714	Associated with various cellular activities
HYB91_RS11185	COG0569	domain protein
HYB91_RS11190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYB91_RS11195	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HYB91_RS11225	COG0616	signal peptide processing
HYB91_RS11230	COG0012	GTP binding
HYB91_RS11255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYB91_RS11265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYB91_RS11270	COG0569	domain protein
HYB91_RS11280	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HYB91_RS11305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYB91_RS11320	COG1129	ABC transporter
HYB91_RS11335	COG0596	Alpha beta hydrolase
HYB91_RS11365	COG1132	(ABC) transporter
HYB91_RS11365	COG2375	cellular response to nickel ion
HYB91_RS11370	COG1132	(ABC) transporter
HYB91_RS11420	COG1846	Transcriptional regulator
HYB91_RS11425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HYB91_RS11440	COG1129	ABC transporter
HYB91_RS11455	COG0733	neurotransmitter:sodium symporter activity
HYB91_RS11465	COG3189	MarR family transcriptional regulator
HYB91_RS11470	COG1309	transcriptional regulator
HYB91_RS11475	COG1132	(ABC) transporter
HYB91_RS11480	COG1132	(ABC) transporter
HYB91_RS11485	COG1129	ABC transporter
HYB91_RS11505	COG1129	ABC transporter
HYB91_RS11520	COG1132	(ABC) transporter
HYB91_RS11525	COG1132	(ABC) transporter
HYB91_RS11525	COG2375	cellular response to nickel ion
HYB91_RS11560	COG1418	mRNA catabolic process
HYB91_RS11580	COG3177	Filamentation induced by cAMP protein fic
HYB91_RS11585	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HYB91_RS11590	COG0592	DNA-directed DNA polymerase activity
HYB91_RS11595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYB91_RS11645	COG0477	Major facilitator Superfamily
HYB91_RS11650	COG1473	amidohydrolase
HYB91_RS11705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYB91_RS11720	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HYB91_RS11725	COG1929	Belongs to the glycerate kinase type-1 family
HYB91_RS11730	COG2610	gluconate transmembrane transporter activity
HYB91_RS11970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYB91_RS11985	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYB91_RS12040	COG2184	nucleotidyltransferase activity
HYB91_RS12050	COG0730	response to heat
HYB91_RS12070	COG4208	sulfate ABC transporter
HYB91_RS12085	COG0840	transmembrane signaling receptor activity
HYB91_RS12100	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HYB91_RS12110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HYB91_RS12115	COG1674	ftsk spoiiie
HYB91_RS12120	COG1968	undecaprenyl-diphosphatase activity
HYB91_RS12125	COG0419	ATPase involved in DNA repair
HYB91_RS12130	COG0420	3'-5' exonuclease activity
HYB91_RS12135	COG0840	transmembrane signaling receptor activity
HYB91_RS12135	COG3290	protein histidine kinase activity
HYB91_RS12145	COG1131	(ABC) transporter
HYB91_RS12165	COG0716	FMN binding
HYB91_RS12200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYB91_RS12255	COG4585	Histidine kinase
HYB91_RS12260	COG1473	amidohydrolase
HYB91_RS12270	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HYB91_RS12275	COG4143	(ABC) transporter
HYB91_RS12285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYB91_RS12290	COG1070	Carbohydrate kinase
HYB91_RS12300	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYB91_RS12310	COG2186	Transcriptional regulator
HYB91_RS12320	COG1823	symporter activity
HYB91_RS12325	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HYB91_RS12325	COG0540	Belongs to the ATCase OTCase family
HYB91_RS12330	COG5002	protein histidine kinase activity
HYB91_RS12330	COG5001	Diguanylate cyclase
HYB91_RS12390	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HYB91_RS12405	COG1774	PSP1 C-terminal conserved region
HYB91_RS12410	COG1728	Protein conserved in bacteria
HYB91_RS12420	COG0739	heme binding
HYB91_RS12435	COG0366	Alpha amylase catalytic
HYB91_RS12445	COG1609	Transcriptional regulator
HYB91_RS12470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYB91_RS12475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYB91_RS12480	COG1104	cysteine desulfurase activity
HYB91_RS12495	COG0823	Involved in the tonB-independent uptake of proteins
HYB91_RS12495	COG1506	peptidase
HYB91_RS12495	COG4946	Tricorn protease homolog
HYB91_RS12525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYB91_RS12530	COG0215	cysteine-tRNA ligase activity
HYB91_RS12545	COG1305	Transglutaminase-like
HYB91_RS12550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYB91_RS12555	COG0569	domain protein
HYB91_RS12560	COG2887	Belongs to the helicase family. UvrD subfamily
HYB91_RS12565	COG1074	ATP-dependent DNA helicase activity
HYB91_RS12570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYB91_RS12590	COG0840	transmembrane signaling receptor activity
HYB91_RS12595	COG0826	peptidase U32
HYB91_RS12600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYB91_RS12605	COG1509	lysine 2,3-aminomutase activity
HYB91_RS12610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYB91_RS12615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYB91_RS12630	COG0205	6-phosphofructokinase activity
HYB91_RS12660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYB91_RS12670	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYB91_RS12675	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYB91_RS12680	COG1684	flagellar biosynthetic protein fliR
HYB91_RS12685	COG1987	bacterial-type flagellum assembly
HYB91_RS12710	COG1228	amidohydrolase
HYB91_RS12725	COG0457	Tetratricopeptide repeat
HYB91_RS12730	COG0280	phosphate acetyltransferase
HYB91_RS12740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYB91_RS12745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYB91_RS12760	COG0537	adenosine 5'-monophosphoramidase activity
HYB91_RS12795	COG1132	(ABC) transporter
HYB91_RS12825	COG1472	Belongs to the glycosyl hydrolase 3 family
HYB91_RS12845	COG0423	glycine-tRNA ligase activity
HYB91_RS12850	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HYB91_RS12860	COG1363	Peptidase, m42
HYB91_RS12880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYB91_RS12885	COG1966	Carbon starvation protein
HYB91_RS12890	COG0450	alkyl hydroperoxide reductase
HYB91_RS12895	COG0494	nUDIX hydrolase
HYB91_RS12915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYB91_RS12935	COG0187	DNA topoisomerase II activity