locus-tag	class	description
E4O06_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4O06_RS00025	COG0587	DNA-directed DNA polymerase activity
E4O06_RS00050	COG1132	(ABC) transporter
E4O06_RS00065	COG1132	(ABC) transporter
E4O06_RS00120	COG1473	amidohydrolase
E4O06_RS00125	COG0745	RESPONSE REGULATOR receiver
E4O06_RS00130	COG5002	protein histidine kinase activity
E4O06_RS00135	COG1136	(ABC) transporter
E4O06_RS00175	COG2378	regulation of single-species biofilm formation
E4O06_RS00190	COG2885	chlorophyll binding
E4O06_RS00195	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4O06_RS00195	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O06_RS00195	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O06_RS00195	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O06_RS00205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4O06_RS00205	COG1747	RNA polymerase binding
E4O06_RS00220	COG0504	CTP synthase activity
E4O06_RS00230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4O06_RS00235	COG1419	protein localization to endoplasmic reticulum
E4O06_RS00250	COG1191	sigma factor activity
E4O06_RS00280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4O06_RS00310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4O06_RS00315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O06_RS00320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4O06_RS00335	COG0516	GMP reductase activity
E4O06_RS00340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4O06_RS00360	COG0784	Response regulator, receiver
E4O06_RS00360	COG3437	response regulator, receiver
E4O06_RS00365	COG1797	cobyrinic acid a,c-diamide synthase activity
E4O06_RS00420	COG1132	(ABC) transporter
E4O06_RS00425	COG4175	Glycine betaine
E4O06_RS00425	COG0517	IMP dehydrogenase activity
E4O06_RS00435	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O06_RS00440	COG0579	oxidoreductase
E4O06_RS00450	COG3177	Filamentation induced by cAMP protein fic
E4O06_RS00500	COG1086	Polysaccharide biosynthesis protein
E4O06_RS00530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O06_RS00545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4O06_RS00570	COG3409	Peptidoglycan-binding domain 1 protein
E4O06_RS00570	COG0793	Belongs to the peptidase S41A family
E4O06_RS00580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4O06_RS00630	COG3118	belongs to the thioredoxin family
E4O06_RS00640	COG1120	ATPase activity
E4O06_RS00645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O06_RS00660	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4O06_RS00660	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4O06_RS00665	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E4O06_RS00670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4O06_RS00690	COG0732	type I restriction modification DNA specificity domain
E4O06_RS00720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4O06_RS00725	COG0135	phosphoribosylanthranilate isomerase activity
E4O06_RS00730	COG1757	Na H antiporter
E4O06_RS00735	COG1120	ATPase activity
E4O06_RS00740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O06_RS00765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4O06_RS00770	COG0051	transcription antitermination factor activity, RNA binding
E4O06_RS00775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4O06_RS00780	COG0088	Forms part of the polypeptide exit tunnel
E4O06_RS00785	COG0089	rRNA binding
E4O06_RS00790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4O06_RS00795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4O06_RS00800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4O06_RS00805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4O06_RS00810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4O06_RS00815	COG0255	Belongs to the universal ribosomal protein uL29 family
E4O06_RS00820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4O06_RS00825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4O06_RS00830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4O06_RS00835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4O06_RS00840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4O06_RS00845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4O06_RS00850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4O06_RS00855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4O06_RS00860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4O06_RS00865	COG1841	ribosomal large subunit assembly
E4O06_RS00870	COG0200	Binds to the 23S rRNA
E4O06_RS00880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4O06_RS00885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4O06_RS00890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4O06_RS00895	COG0202	RNA polymerase activity
E4O06_RS00900	COG0203	ribosomal protein L17
E4O06_RS00920	COG1254	Belongs to the acylphosphatase family
E4O06_RS00940	COG0584	glycerophosphoryl diester phosphodiesterase
E4O06_RS00965	COG2226	methyltransferase
E4O06_RS00970	COG1959	2 iron, 2 sulfur cluster binding
E4O06_RS00975	COG2910	NAD(P)H-binding
E4O06_RS00995	COG0840	transmembrane signaling receptor activity
E4O06_RS01090	COG1131	(ABC) transporter
E4O06_RS01105	COG0640	Transcriptional regulator
E4O06_RS01115	COG4942	peptidase
E4O06_RS01135	COG3290	protein histidine kinase activity
E4O06_RS01135	COG0840	transmembrane signaling receptor activity
E4O06_RS01150	COG2207	Transcriptional regulator
E4O06_RS01155	COG2274	protein secretion by the type I secretion system
E4O06_RS01160	COG1132	(ABC) transporter
E4O06_RS01170	COG1741	Belongs to the pirin family
E4O06_RS01215	COG1132	(ABC) transporter
E4O06_RS01225	COG1129	ABC transporter
E4O06_RS01245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4O06_RS01250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4O06_RS01255	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4O06_RS01270	COG1132	(ABC) transporter
E4O06_RS01275	COG4988	ABC transporter
E4O06_RS01285	COG1121	(ABC) transporter
E4O06_RS01290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O06_RS01320	COG0301	tRNA thio-modification
E4O06_RS01330	COG0328	RNA-DNA hybrid ribonuclease activity
E4O06_RS01335	COG4443	Transcriptional Coactivator p15 (PC4)
E4O06_RS01340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O06_RS01345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O06_RS01360	COG4657	Part of a membrane complex involved in electron transport
E4O06_RS01365	COG4660	Part of a membrane complex involved in electron transport
E4O06_RS01370	COG4659	FMN binding
E4O06_RS01375	COG4658	electron transport chain
E4O06_RS01380	COG4656	Part of a membrane complex involved in electron transport
E4O06_RS01390	COG2304	oxidoreductase activity
E4O06_RS01410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4O06_RS01425	COG0840	transmembrane signaling receptor activity
E4O06_RS01440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4O06_RS01455	COG0745	RESPONSE REGULATOR receiver
E4O06_RS01480	COG1187	pseudouridine synthase activity
E4O06_RS01485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4O06_RS01495	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4O06_RS01500	COG4988	ABC transporter
E4O06_RS01525	COG1362	aminopeptidase activity
E4O06_RS01530	COG0445	tRNA wobble uridine modification
E4O06_RS01555	COG2604	Protein of unknown function DUF115
E4O06_RS01570	COG1132	(ABC) transporter
E4O06_RS01595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4O06_RS01605	COG4115	mRNA cleavage
E4O06_RS01620	COG0357	Ribosomal RNA small subunit methyltransferase G
E4O06_RS01625	COG1012	belongs to the aldehyde dehydrogenase family
E4O06_RS01645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4O06_RS01660	COG0745	RESPONSE REGULATOR receiver
E4O06_RS01690	COG1573	uracil-dna glycosylase
E4O06_RS01695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4O06_RS01720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4O06_RS01725	COG2890	protein-(glutamine-N5) methyltransferase activity
E4O06_RS01725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4O06_RS01750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4O06_RS01785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O06_RS01795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O06_RS01800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4O06_RS01810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4O06_RS01815	COG0706	membrane insertase activity
E4O06_RS01820	COG1847	R3H domain protein
E4O06_RS01830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4O06_RS01845	COG0740	serine-type endopeptidase activity
E4O06_RS01860	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4O06_RS01870	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4O06_RS01880	COG4585	Histidine kinase
E4O06_RS01895	COG1131	(ABC) transporter
E4O06_RS01900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4O06_RS01920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4O06_RS01935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4O06_RS01945	COG1757	Na H antiporter
E4O06_RS01965	COG2376	Dihydroxyacetone kinase
E4O06_RS01970	COG2376	Dihydroxyacetone kinase
E4O06_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O06_RS02005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4O06_RS02010	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4O06_RS02015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O06_RS02035	COG1413	lyase activity
E4O06_RS02040	COG0424	maF-like protein
E4O06_RS02045	COG0052	Belongs to the universal ribosomal protein uS2 family
E4O06_RS02050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4O06_RS02055	COG0233	cytoplasmic translational termination
E4O06_RS02060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4O06_RS02065	COG0575	Belongs to the CDS family
E4O06_RS02070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4O06_RS02075	COG0750	zinc metalloprotease
E4O06_RS02085	COG0495	leucyl-tRNA aminoacylation
E4O06_RS02100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4O06_RS02110	COG2183	response to ionizing radiation
E4O06_RS02115	COG2703	oxygen carrier activity
E4O06_RS02125	COG1067	ATP-dependent peptidase activity
E4O06_RS02140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4O06_RS02140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4O06_RS02160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4O06_RS02170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4O06_RS02175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4O06_RS02180	COG0571	ribonuclease III activity
E4O06_RS02185	COG0071	Belongs to the small heat shock protein (HSP20) family
E4O06_RS02195	COG0617	tRNA 3'-terminal CCA addition
E4O06_RS02200	COG0598	Magnesium transport protein CorA
E4O06_RS02210	COG0840	transmembrane signaling receptor activity
E4O06_RS02215	COG0196	riboflavin kinase activity
E4O06_RS02220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4O06_RS02225	COG1185	polyribonucleotide nucleotidyltransferase activity
E4O06_RS02230	COG0756	dUTP diphosphatase activity
E4O06_RS02245	COG4865	methylaspartate mutase activity
E4O06_RS02255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4O06_RS02260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O06_RS02265	COG1120	ATPase activity
E4O06_RS02270	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O06_RS02280	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O06_RS02300	COG0442	prolyl-tRNA aminoacylation
E4O06_RS02320	COG1879	ABC-type sugar transport system periplasmic component
E4O06_RS02325	COG1129	ABC transporter
E4O06_RS02330	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4O06_RS02335	COG2226	methyltransferase
E4O06_RS02350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O06_RS02360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4O06_RS02375	COG2056	Na+-H+ antiporter family
E4O06_RS02380	COG1757	Na H antiporter
E4O06_RS02385	COG0697	spore germination
E4O06_RS02395	COG0626	cystathionine gamma-synthase activity
E4O06_RS02400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4O06_RS02405	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O06_RS02405	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O06_RS02405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O06_RS02405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O06_RS02410	COG0564	pseudouridine synthase activity
E4O06_RS02415	COG0156	8-amino-7-oxononanoate synthase activity
E4O06_RS02425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4O06_RS02435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4O06_RS02435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4O06_RS02440	COG0739	heme binding
E4O06_RS02450	COG1475	DNA binding
E4O06_RS02455	COG1022	Amp-dependent synthetase and ligase
E4O06_RS02480	COG0671	phosphoesterase, PA-phosphatase related
E4O06_RS02485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4O06_RS02545	COG2738	Putative neutral zinc metallopeptidase
E4O06_RS02560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4O06_RS02575	COG1129	ABC transporter
E4O06_RS02615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4O06_RS02620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4O06_RS02630	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4O06_RS02635	COG1671	Belongs to the UPF0178 family
E4O06_RS02645	COG0741	lytic transglycosylase activity
E4O06_RS02645	COG1388	LysM domain
E4O06_RS02670	COG3681	Belongs to the UPF0597 family
E4O06_RS02675	COG4953	penicillin-binding protein 1C
E4O06_RS02680	COG1770	oligopeptidase
E4O06_RS02705	COG1114	Component of the transport system for branched-chain amino acids
E4O06_RS02720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O06_RS02745	COG2723	6-phospho-beta-galactosidase activity
E4O06_RS02760	COG0488	(ABC) transporter
E4O06_RS02790	COG1266	CAAX protease self-immunity
E4O06_RS02795	COG1266	CAAX protease self-immunity
E4O06_RS02835	COG3271	cysteine-type peptidase activity
E4O06_RS02835	COG2274	protein secretion by the type I secretion system
E4O06_RS02845	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4O06_RS02850	COG0632	four-way junction helicase activity
E4O06_RS02880	COG2056	Na+-H+ antiporter family
E4O06_RS02900	COG1136	(ABC) transporter
E4O06_RS02935	COG1122	ATPase activity
E4O06_RS02980	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4O06_RS02990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4O06_RS03025	COG1132	(ABC) transporter
E4O06_RS03045	COG2770	Histidine kinase
E4O06_RS03045	COG2208	phosphoserine phosphatase activity
E4O06_RS03050	COG1131	(ABC) transporter
E4O06_RS03070	COG0284	orotidine-5'-phosphate decarboxylase activity
E4O06_RS03090	COG0513	Belongs to the DEAD box helicase family
E4O06_RS03100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4O06_RS03145	COG3876	Protein conserved in bacteria
E4O06_RS03150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4O06_RS03165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4O06_RS03170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4O06_RS03175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4O06_RS03180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4O06_RS03185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4O06_RS03195	COG0528	UMP kinase activity
E4O06_RS03200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4O06_RS03215	COG0539	negative regulation of cytoplasmic translation
E4O06_RS03220	COG2204	response regulator
E4O06_RS03225	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4O06_RS03245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4O06_RS03270	COG0251	oxidation-reduction process
E4O06_RS03275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4O06_RS03280	COG1722	exodeoxyribonuclease VII activity
E4O06_RS03300	COG1918	ferrous iron import across plasma membrane
E4O06_RS03305	COG1918	ferrous iron import across plasma membrane
E4O06_RS03305	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4O06_RS03350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O06_RS03385	COG4166	transmembrane transport
E4O06_RS03415	COG0552	protein localization to endoplasmic reticulum
E4O06_RS03425	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4O06_RS03430	COG1136	(ABC) transporter
E4O06_RS03440	COG3880	PFAM UvrB UvrC protein
E4O06_RS03445	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4O06_RS03455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4O06_RS03460	COG0438	transferase activity, transferring glycosyl groups
E4O06_RS03470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4O06_RS03480	COG0084	hydrolase, TatD family'
E4O06_RS03485	COG2885	chlorophyll binding
E4O06_RS03575	COG3039	Transposase
E4O06_RS03600	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O06_RS03610	COG1288	antiporter activity
E4O06_RS03635	COG1309	transcriptional regulator
E4O06_RS03645	COG1164	Oligoendopeptidase f
E4O06_RS03650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O06_RS03655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4O06_RS03660	COG0606	chelatase, subunit chli
E4O06_RS03670	COG2885	chlorophyll binding
E4O06_RS03675	COG0433	COG0433 Predicted ATPase
E4O06_RS03685	COG0768	penicillin binding
E4O06_RS03690	COG2604	Protein of unknown function DUF115
E4O06_RS03715	COG1739	Uncharacterized protein family UPF0029
E4O06_RS03740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4O06_RS03750	COG0330	HflC and HflK could
E4O06_RS03755	COG0330	HflC and HflK could
E4O06_RS03775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4O06_RS03780	COG2088	sporulation resulting in formation of a cellular spore
E4O06_RS03790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4O06_RS03795	COG0037	tRNA processing
E4O06_RS03800	COG0457	Tetratricopeptide repeat
E4O06_RS03805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O06_RS03820	COG0358	DNA primase activity
E4O06_RS03825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O06_RS03845	COG1077	Cell shape determining protein MreB Mrl
E4O06_RS03860	COG0768	penicillin binding
E4O06_RS03865	COG0772	Belongs to the SEDS family
E4O06_RS03900	COG2252	PERMEase
E4O06_RS03925	COG1794	racemase activity, acting on amino acids and derivatives
E4O06_RS03980	COG1715	Restriction endonuclease
E4O06_RS04120	COG0534	Mate efflux family protein
E4O06_RS04420	COG3039	Transposase
E4O06_RS04455	COG2226	methyltransferase
E4O06_RS04470	COG0406	alpha-ribazole phosphatase activity
E4O06_RS04480	COG3039	Transposase
E4O06_RS04490	COG1418	mRNA catabolic process
E4O06_RS04520	COG2033	superoxide reductase activity
E4O06_RS04525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4O06_RS04535	COG2720	vancomycin resistance protein
E4O06_RS04540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4O06_RS04550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4O06_RS04555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4O06_RS04570	COG0799	negative regulation of ribosome biogenesis
E4O06_RS04575	COG2059	Chromate
E4O06_RS04620	COG0739	heme binding
E4O06_RS04630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O06_RS04640	COG0708	Exodeoxyribonuclease III
E4O06_RS04645	COG0024	Methionine aminopeptidase
E4O06_RS04650	COG0484	heat shock protein binding
E4O06_RS04670	COG1233	COG1233 Phytoene dehydrogenase and related
E4O06_RS04675	COG1017	nitric oxide dioxygenase activity
E4O06_RS04675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4O06_RS04690	COG0617	tRNA 3'-terminal CCA addition
E4O06_RS04705	COG0519	Catalyzes the synthesis of GMP from XMP
E4O06_RS04715	COG0126	phosphoglycerate kinase activity
E4O06_RS04720	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4O06_RS04740	COG0268	Binds directly to 16S ribosomal RNA
E4O06_RS04750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4O06_RS04760	COG1058	Belongs to the CinA family
E4O06_RS04760	COG1546	Belongs to the CinA family
E4O06_RS04810	COG0588	phosphoglycerate mutase activity
E4O06_RS04830	COG1131	(ABC) transporter
E4O06_RS04840	COG0457	Tetratricopeptide repeat
E4O06_RS04845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4O06_RS04850	COG2203	Gaf domain
E4O06_RS04850	COG3706	GGDEF domain
E4O06_RS04850	COG5001	Diguanylate cyclase
E4O06_RS04850	COG4251	negative regulation of phosphorylation
E4O06_RS04855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4O06_RS04860	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4O06_RS04865	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4O06_RS04870	COG1394	ATPase activity, coupled to movement of substances
E4O06_RS04875	COG1269	ATP hydrolysis coupled proton transport
E4O06_RS04885	COG0360	Binds together with S18 to 16S ribosomal RNA
E4O06_RS04890	COG0629	single-stranded DNA binding
E4O06_RS04895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4O06_RS04900	COG0359	binds to the 23S rRNA
E4O06_RS04910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4O06_RS04915	COG0740	serine-type endopeptidase activity
E4O06_RS04920	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4O06_RS04940	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O06_RS04950	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4O06_RS04970	COG0305	Participates in initiation and elongation during chromosome replication
E4O06_RS04980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4O06_RS04985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4O06_RS04990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4O06_RS05010	COG1268	BioY protein
E4O06_RS05015	COG1122	ATPase activity
E4O06_RS05020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E4O06_RS05040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O06_RS05055	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4O06_RS05060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4O06_RS05070	COG0237	dephospho-CoA kinase activity
E4O06_RS05075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O06_RS05075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O06_RS05075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O06_RS05100	COG3052	prosthetic group binding
E4O06_RS05120	COG1737	Transcriptional regulator
E4O06_RS05125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4O06_RS05135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O06_RS05150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4O06_RS05155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4O06_RS05160	COG0509	glycine decarboxylation via glycine cleavage system
E4O06_RS05165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O06_RS05170	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O06_RS05210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4O06_RS05215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O06_RS05215	COG0493	'glutamate synthase
E4O06_RS05240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4O06_RS05280	COG1051	belongs to the nudix hydrolase family
E4O06_RS05295	COG1051	belongs to the nudix hydrolase family
E4O06_RS05330	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4O06_RS05335	COG0488	(ABC) transporter
E4O06_RS05340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4O06_RS05350	COG0835	chemotaxis
E4O06_RS05360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4O06_RS05380	COG0297	glycogen (starch) synthase activity
E4O06_RS05385	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4O06_RS05390	COG2982	Protein involved in outer membrane biogenesis
E4O06_RS05415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O06_RS05420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4O06_RS05425	COG0095	Lipoate-protein ligase
E4O06_RS05430	COG4608	Belongs to the ABC transporter superfamily
E4O06_RS05435	COG0444	Belongs to the ABC transporter superfamily
E4O06_RS05440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_RS05445	COG0601	transmembrane transport
E4O06_RS05450	COG0747	negative chemotaxis
E4O06_RS05455	COG0205	6-phosphofructokinase activity
E4O06_RS05460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4O06_RS05465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4O06_RS05470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4O06_RS05490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4O06_RS05505	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4O06_RS05525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4O06_RS05530	COG0142	geranyltranstransferase activity
E4O06_RS05540	COG1692	metallophosphoesterase
E4O06_RS05570	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4O06_RS05600	COG1136	(ABC) transporter
E4O06_RS05605	COG0577	efflux transmembrane transporter activity
E4O06_RS05620	COG3470	protein probably involved in high-affinity Fe2 transport
E4O06_RS05625	COG0672	)-iron permease
E4O06_RS05630	COG1136	(ABC) transporter
E4O06_RS05640	COG1760	l-serine dehydratase
E4O06_RS05645	COG1760	l-serine dehydratase
E4O06_RS05655	COG0254	rRNA binding
E4O06_RS05660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4O06_RS05675	COG0574	Belongs to the PEP-utilizing enzyme family
E4O06_RS05675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O06_RS05685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4O06_RS05740	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O06_RS05750	COG1196	nuclear chromosome segregation
E4O06_RS05760	COG2201	protein-glutamate methylesterase activity
E4O06_RS05770	COG0835	chemotaxis
E4O06_RS05775	COG2198	Histidine kinase
E4O06_RS05775	COG0643	Histidine kinase
E4O06_RS05790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4O06_RS05795	COG0217	transcriptional regulatory protein
E4O06_RS05830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O06_RS05835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O06_RS05845	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4O06_RS05845	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4O06_RS05860	COG0802	atpase or kinase
E4O06_RS05870	COG2770	Histidine kinase
E4O06_RS05870	COG3437	response regulator, receiver
E4O06_RS05875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4O06_RS05885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4O06_RS05930	COG1136	(ABC) transporter
E4O06_RS05960	COG3292	Two component regulator propeller
E4O06_RS05960	COG0745	RESPONSE REGULATOR receiver
E4O06_RS05960	COG2205	protein histidine kinase activity
E4O06_RS05965	COG0745	RESPONSE REGULATOR receiver
E4O06_RS05975	COG2190	(PTS) system
E4O06_RS05975	COG2211	Major facilitator Superfamily
E4O06_RS05985	COG1193	negative regulation of DNA recombination
E4O06_RS05990	COG1162	GTPase activity
E4O06_RS06000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O06_RS06015	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4O06_RS06025	COG0124	histidyl-tRNA synthetase
E4O06_RS06040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O06_RS06045	COG0297	glycogen (starch) synthase activity
E4O06_RS06055	COG0706	membrane insertase activity
E4O06_RS06070	COG0706	membrane insertase activity
E4O06_RS06080	COG0463	Glycosyl transferase, family 2
E4O06_RS06085	COG3306	glycosyltransferase involved in LPS biosynthesis
E4O06_RS06090	COG1442	glycosyl transferase family 8
E4O06_RS06090	COG1216	Glycosyl transferase, family 2
E4O06_RS06125	COG0463	Glycosyl transferase, family 2
E4O06_RS06125	COG1216	Glycosyl transferase, family 2
E4O06_RS06150	COG2089	acid synthase
E4O06_RS06170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O06_RS06170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O06_RS06180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O06_RS06220	COG4310	Domain of unknown function (DUF2172)
E4O06_RS06230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4O06_RS06235	COG1083	cytidylyl-transferase
E4O06_RS06245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4O06_RS06250	COG1086	Polysaccharide biosynthesis protein
E4O06_RS06280	COG1373	ATPase (AAA superfamily
E4O06_RS06285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4O06_RS06290	COG0028	Belongs to the TPP enzyme family
E4O06_RS06290	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4O06_RS06310	COG0475	glutathione-regulated potassium exporter activity
E4O06_RS06335	COG1078	dGTPase activity
E4O06_RS06345	COG0047	phosphoribosylformylglycinamidine synthase activity
E4O06_RS06355	COG0488	(ABC) transporter
E4O06_RS06370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4O06_RS06370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4O06_RS06375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4O06_RS06385	COG0455	bacterial-type flagellum organization
E4O06_RS06415	COG4656	Part of a membrane complex involved in electron transport
E4O06_RS06430	COG0564	pseudouridine synthase activity
E4O06_RS06435	COG2217	Heavy metal translocating P-type atpase
E4O06_RS06440	COG0640	Transcriptional regulator
E4O06_RS06445	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4O06_RS06465	COG2878	Part of a membrane complex involved in electron transport
E4O06_RS06470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4O06_RS06475	COG0138	bifunctional purine biosynthesis protein purh
E4O06_RS06480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4O06_RS06485	COG0653	protein targeting
E4O06_RS06490	COG1725	Transcriptional regulator
E4O06_RS06510	COG0736	holo-[acyl-carrier-protein] synthase activity
E4O06_RS06520	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4O06_RS06525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4O06_RS06530	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4O06_RS06540	COG2255	four-way junction helicase activity
E4O06_RS06545	COG1979	alcohol dehydrogenase
E4O06_RS06550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O06_RS06565	COG0731	radical SAM domain protein
E4O06_RS06580	COG1047	Peptidyl-prolyl cis-trans
E4O06_RS06615	COG0295	cytidine deaminase activity
E4O06_RS06635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4O06_RS06665	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O06_RS06670	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O06_RS06675	COG3845	ABC transporter
E4O06_RS06680	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O06_RS06685	COG1234	tRNA 3'-trailer cleavage
E4O06_RS06705	COG0525	valine-tRNA ligase activity
E4O06_RS06710	COG0481	GTPase activity
E4O06_RS06715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4O06_RS06725	COG0557	exoribonuclease II activity
E4O06_RS06730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4O06_RS06730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4O06_RS06735	COG0556	nucleotide-excision repair
E4O06_RS06740	COG1136	(ABC) transporter
E4O06_RS06775	COG1132	(ABC) transporter
E4O06_RS06780	COG1132	(ABC) transporter
E4O06_RS06780	COG2375	cellular response to nickel ion
E4O06_RS06785	COG2207	Transcriptional regulator
E4O06_RS06795	COG4555	ABC transporter
E4O06_RS06810	COG1136	(ABC) transporter
E4O06_RS06815	COG3271	cysteine-type peptidase activity
E4O06_RS06815	COG2274	protein secretion by the type I secretion system
E4O06_RS06825	COG0535	radical SAM domain protein
E4O06_RS06885	COG2378	regulation of single-species biofilm formation
E4O06_RS06895	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4O06_RS06900	COG0475	glutathione-regulated potassium exporter activity
E4O06_RS06905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O06_RS06915	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4O06_RS06920	COG2204	response regulator
E4O06_RS06925	COG3852	Histidine kinase
E4O06_RS06930	COG0470	DNA polymerase III
E4O06_RS06935	COG1286	toxin biosynthetic process
E4O06_RS06950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4O06_RS06955	COG1349	DNA-binding transcription factor activity
E4O06_RS06970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4O06_RS06990	COG0823	Involved in the tonB-independent uptake of proteins
E4O06_RS07000	COG1199	ATP-dependent helicase activity
E4O06_RS07005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4O06_RS07020	COG0497	DNA recombination
E4O06_RS07040	COG3942	CHAP domain
E4O06_RS07040	COG1388	LysM domain
E4O06_RS07050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4O06_RS07055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O06_RS07060	COG0312	modulator of DNA gyrase
E4O06_RS07085	COG1122	ATPase activity
E4O06_RS07170	COG4254	PFAM FecR protein
E4O06_RS07210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4O06_RS07215	COG4475	Protein of unknown function (DUF436)
E4O06_RS07230	COG3039	Transposase
E4O06_RS07265	COG0840	transmembrane signaling receptor activity
E4O06_RS07270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4O06_RS07275	COG3118	belongs to the thioredoxin family
E4O06_RS07290	COG4750	Nucleotidyl transferase
E4O06_RS07295	COG1115	amino acid carrier protein
E4O06_RS07320	COG2840	Smr protein MutS2
E4O06_RS07375	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4O06_RS07380	COG1480	7TM receptor with intracellular HD hydrolase
E4O06_RS07385	COG1702	phosphate starvation-inducible protein PhoH
E4O06_RS07400	COG0149	triose-phosphate isomerase activity
E4O06_RS07420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O06_RS07440	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O06_RS07445	COG1121	(ABC) transporter
E4O06_RS07450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O06_RS07455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O06_RS07470	COG0457	Tetratricopeptide repeat
E4O06_RS07480	COG1157	protein secretion by the type III secretion system
E4O06_RS07485	COG1317	bacterial-type flagellum organization
E4O06_RS07495	COG1766	The M ring may be actively involved in energy transduction
E4O06_RS07500	COG1677	Flagellar hook-basal body complex protein FliE
E4O06_RS07515	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4O06_RS07520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4O06_RS07525	COG4974	Belongs to the 'phage' integrase family
E4O06_RS07530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4O06_RS07530	COG0551	DNA topoisomerase type I activity
E4O06_RS07535	COG0758	DNA mediated transformation
E4O06_RS07550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4O06_RS07565	COG0772	Belongs to the SEDS family
E4O06_RS07570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4O06_RS07580	COG0275	rRNA processing
E4O06_RS07585	COG2001	Belongs to the MraZ family
E4O06_RS07590	COG1505	serine-type exopeptidase activity
E4O06_RS07625	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4O06_RS07635	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4O06_RS07675	COG0459	protein refolding
E4O06_RS07690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4O06_RS07695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4O06_RS07735	COG1366	Belongs to the anti-sigma-factor antagonist family
E4O06_RS07755	COG3033	Beta-eliminating lyase
E4O06_RS07760	COG0563	adenylate kinase activity
E4O06_RS07780	COG0779	Required for maturation of 30S ribosomal subunits
E4O06_RS07790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4O06_RS07795	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4O06_RS07800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4O06_RS07820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_RS07830	COG0747	negative chemotaxis
E4O06_RS07860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4O06_RS07865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4O06_RS07875	COG3330	Domain of unknown function (DUF4912)
E4O06_RS07890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O06_RS07900	COG3706	GGDEF domain
E4O06_RS07905	COG1102	Psort location Cytoplasmic, score
E4O06_RS07910	COG1561	YicC-like family, N-terminal region
E4O06_RS07920	COG0285	dihydrofolate synthase activity
E4O06_RS07940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4O06_RS07945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O06_RS07955	COG4608	Belongs to the ABC transporter superfamily
E4O06_RS07960	COG0444	Belongs to the ABC transporter superfamily
E4O06_RS07965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_RS07970	COG0601	transmembrane transport
E4O06_RS07985	COG0601	transmembrane transport
E4O06_RS07990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_RS07995	COG0444	Belongs to the ABC transporter superfamily
E4O06_RS08000	COG4608	Belongs to the ABC transporter superfamily
E4O06_RS08020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O06_RS08020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O06_RS08050	COG0534	Mate efflux family protein
E4O06_RS08055	COG0840	transmembrane signaling receptor activity
E4O06_RS08070	COG2801	Transposase and inactivated derivatives
E4O06_RS08105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O06_RS08110	COG0049	tRNA binding
E4O06_RS08115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4O06_RS08145	COG0629	single-stranded DNA binding
E4O06_RS08160	COG0863	Belongs to the N(4) N(6)-methyltransferase family
E4O06_RS08360	COG3645	SOS response
E4O06_RS08385	COG2832	Protein of unknown function (DUF454)
E4O06_RS08390	COG3142	Participates in the control of copper homeostasis
E4O06_RS08415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4O06_RS08450	COG0737	Belongs to the 5'-nucleotidase family
E4O06_RS08465	COG0826	peptidase U32
E4O06_RS08475	COG1132	(ABC) transporter
E4O06_RS08480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4O06_RS08495	COG0101	tRNA pseudouridine synthase activity
E4O06_RS08505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4O06_RS08510	COG1639	'signal transduction protein
E4O06_RS08525	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4O06_RS08530	COG0577	efflux transmembrane transporter activity
E4O06_RS08530	COG1136	(ABC) transporter
E4O06_RS08535	COG1136	(ABC) transporter
E4O06_RS08550	COG3956	TIGRFAM MazG family protein
E4O06_RS08555	COG0545	Peptidyl-prolyl cis-trans isomerase
E4O06_RS08560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O06_RS08570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O06_RS08570	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4O06_RS08575	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O06_RS08590	COG0668	transmembrane transport
E4O06_RS08605	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O06_RS08610	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4O06_RS08615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O06_RS08630	COG0792	nuclease activity
E4O06_RS08645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4O06_RS08665	COG3604	Transcriptional regulator
E4O06_RS08670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4O06_RS08690	COG1272	protein, Hemolysin III
E4O06_RS08695	COG1196	nuclear chromosome segregation
E4O06_RS08695	COG0741	lytic transglycosylase activity
E4O06_RS08695	COG0739	heme binding
E4O06_RS08720	COG0668	transmembrane transport
E4O06_RS08725	COG2197	response regulator
E4O06_RS08745	COG0542	response to heat
E4O06_RS08750	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4O06_RS08760	COG2855	membrane
E4O06_RS08770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4O06_RS08775	COG1363	Peptidase, m42
E4O06_RS08790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O06_RS08810	COG0058	SHG alpha-glucan phosphorylase activity
E4O06_RS08830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4O06_RS08835	COG0085	RNA polymerase activity
E4O06_RS08840	COG0222	ribosome binding
E4O06_RS08845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4O06_RS08850	COG0081	regulation of translation
E4O06_RS08855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4O06_RS08860	COG0250	Participates in transcription elongation, termination and antitermination
E4O06_RS08865	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4O06_RS08875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4O06_RS08905	COG1652	LysM domain
E4O06_RS08910	COG0726	polysaccharide deacetylase
E4O06_RS08925	COG2274	protein secretion by the type I secretion system
E4O06_RS08955	COG3620	sequence-specific DNA binding
E4O06_RS08965	COG0281	malic enzyme
E4O06_RS08985	COG2078	PFAM AMMECR1 domain protein
E4O06_RS08985	COG3885	ferrous iron binding
E4O06_RS08990	COG0666	response to abiotic stimulus
E4O06_RS08995	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4O06_RS09005	COG1129	ABC transporter
E4O06_RS09015	COG1131	(ABC) transporter
E4O06_RS09070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O06_RS09090	COG0425	Belongs to the sulfur carrier protein TusA family
E4O06_RS09105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4O06_RS09120	COG0326	Molecular chaperone. Has ATPase activity
E4O06_RS09145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4O06_RS09150	COG0534	Mate efflux family protein
E4O06_RS09155	COG0549	Belongs to the carbamate kinase family
E4O06_RS09160	COG1921	L-seryl-tRNASec selenium transferase activity
E4O06_RS09170	COG0322	excinuclease ABC activity
E4O06_RS09195	COG0848	biopolymer transport protein
E4O06_RS09200	COG0811	peptide transport
E4O06_RS09255	COG3209	COG3209 Rhs family protein
E4O06_RS09255	COG4104	PAAR repeat-containing protein
E4O06_RS09290	COG0210	DNA helicase
E4O06_RS09295	COG1132	(ABC) transporter
E4O06_RS09300	COG1132	(ABC) transporter
E4O06_RS09305	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4O06_RS09315	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4O06_RS09325	COG4786	Flagellar basal body rod
E4O06_RS09340	COG2084	Dehydrogenase
E4O06_RS09345	COG2116	formate transmembrane transporter activity
E4O06_RS09370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4O06_RS09380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4O06_RS09390	COG4608	Belongs to the ABC transporter superfamily
E4O06_RS09395	COG0444	Belongs to the ABC transporter superfamily
E4O06_RS09405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_RS09410	COG4174	ABC transporter (Permease)
E4O06_RS09425	COG0017	Asparaginyl-tRNA synthetase
E4O06_RS09430	COG1686	Belongs to the peptidase S11 family
E4O06_RS09435	COG2003	Belongs to the UPF0758 family
E4O06_RS09440	COG1040	competence protein
E4O06_RS09445	COG0018	arginyl-trna synthetase
E4O06_RS09450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4O06_RS09465	COG1692	metallophosphoesterase
E4O06_RS09475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4O06_RS09490	COG2089	acid synthase
E4O06_RS09495	COG5341	Protein conserved in bacteria
E4O06_RS09500	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4O06_RS09505	COG0584	glycerophosphoryl diester phosphodiesterase
E4O06_RS09510	COG1704	LemA family
E4O06_RS09515	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O06_RS09520	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O06_RS09525	COG3845	ABC transporter
E4O06_RS09530	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O06_RS09815	COG0148	phosphopyruvate hydratase activity
E4O06_RS09830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O06_RS09875	COG0318	PFAM AMP-dependent synthetase and ligase
E4O06_RS09880	COG0791	NLP P60 protein
E4O06_RS09890	COG3735	TraB family
E4O06_RS09900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O06_RS09905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4O06_RS09920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O06_RS09925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4O06_RS09935	COG0534	Mate efflux family protein
E4O06_RS09940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O06_RS09970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4O06_RS09975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4O06_RS09990	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O06_RS10020	COG1132	(ABC) transporter
E4O06_RS10025	COG1132	(ABC) transporter
E4O06_RS10025	COG2375	cellular response to nickel ion
E4O06_RS10040	COG1129	ABC transporter
E4O06_RS10050	COG1122	ATPase activity
E4O06_RS10055	COG1129	ABC transporter
E4O06_RS10075	COG3621	Patatin-like phospholipase
E4O06_RS10105	COG0210	DNA helicase
E4O06_RS10130	COG0335	large ribosomal subunit rRNA binding
E4O06_RS10135	COG0336	Belongs to the RNA methyltransferase TrmD family
E4O06_RS10140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4O06_RS10145	COG1837	Belongs to the UPF0109 family
E4O06_RS10150	COG0228	four-way junction DNA binding
E4O06_RS10190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4O06_RS10195	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4O06_RS10200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4O06_RS10230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4O06_RS10235	COG1285	pathogenesis
E4O06_RS10260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4O06_RS10285	COG0166	Belongs to the GPI family
E4O06_RS10290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4O06_RS10305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4O06_RS10310	COG3706	GGDEF domain
E4O06_RS10315	COG3706	GGDEF domain
E4O06_RS10335	COG0840	transmembrane signaling receptor activity
E4O06_RS10335	COG3290	protein histidine kinase activity
E4O06_RS10340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4O06_RS10355	COG1362	aminopeptidase activity
E4O06_RS10360	COG1054	Belongs to the UPF0176 family
E4O06_RS10365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4O06_RS10375	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O06_RS10385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4O06_RS10395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4O06_RS10420	COG0724	RNA recognition motif
E4O06_RS10425	COG2264	protein methyltransferase activity
E4O06_RS10430	COG3314	Sporulation integral membrane protein YlbJ
E4O06_RS10435	COG0393	Putative heavy-metal-binding
E4O06_RS10440	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4O06_RS10445	COG2226	methyltransferase
E4O06_RS10450	COG0840	transmembrane signaling receptor activity
E4O06_RS10465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O06_RS10485	COG1477	protein flavinylation
E4O06_RS10490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4O06_RS10495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O06_RS10505	COG0613	PHP domain protein
E4O06_RS10510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4O06_RS10520	COG0330	HflC and HflK could
E4O06_RS10545	COG1131	(ABC) transporter
E4O06_RS10550	COG0351	phosphomethylpyrimidine kinase
E4O06_RS10555	COG0482	sulfurtransferase activity
E4O06_RS10570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4O06_RS10575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4O06_RS10580	COG1028	Short-chain dehydrogenase reductase Sdr
E4O06_RS10585	COG0629	single-stranded DNA binding
E4O06_RS10590	COG1862	Preprotein translocase
E4O06_RS10595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O06_RS10600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O06_RS10605	COG1104	cysteine desulfurase activity
E4O06_RS10615	COG0425	Belongs to the sulfur carrier protein TusA family
E4O06_RS10650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4O06_RS10680	COG0719	Fe-S assembly protein
E4O06_RS10685	COG0396	ATPase activity
E4O06_RS10725	COG2211	Major facilitator Superfamily
E4O06_RS10760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4O06_RS10765	COG0546	phosphoglycolate phosphatase activity
E4O06_RS10775	COG2239	Acts as a magnesium transporter
E4O06_RS10785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4O06_RS10810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O06_RS10815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4O06_RS10825	COG5001	Diguanylate cyclase
E4O06_RS10830	COG1162	GTPase activity
E4O06_RS10840	COG0084	hydrolase, TatD family'
E4O06_RS10845	COG3116	cell division
E4O06_RS10845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4O06_RS10920	COG4974	Belongs to the 'phage' integrase family
E4O06_RS10930	COG0732	type I restriction modification DNA specificity domain
E4O06_RS10940	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4O06_RS10965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4O06_RS10980	COG4545	Glutaredoxin-related protein
E4O06_RS10985	COG0739	heme binding
E4O06_RS10990	COG2423	ornithine cyclodeaminase activity
E4O06_RS10995	COG1115	amino acid carrier protein
E4O06_RS11000	COG4166	transmembrane transport
E4O06_RS11005	COG1338	Plays a role in the flagellum-specific transport system
E4O06_RS11015	COG1776	CheC inhibitor of MCP methylation
E4O06_RS11015	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O06_RS11020	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O06_RS11025	COG1580	Controls the rotational direction of flagella during chemotaxis
E4O06_RS11030	COG1360	Flagellar Motor Protein
E4O06_RS11035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4O06_RS11050	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4O06_RS11070	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4O06_RS11090	COG2201	protein-glutamate methylesterase activity
E4O06_RS11110	COG1137	ATPase activity
E4O06_RS11115	COG0193	aminoacyl-tRNA hydrolase activity
E4O06_RS11125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4O06_RS11130	COG0601	transmembrane transport
E4O06_RS11135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_RS11140	COG0444	Belongs to the ABC transporter superfamily
E4O06_RS11145	COG4608	Belongs to the ABC transporter superfamily
E4O06_RS11155	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4O06_RS11180	COG0484	heat shock protein binding
E4O06_RS11185	COG0443	Heat shock 70 kDa protein
E4O06_RS11190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4O06_RS11195	COG3177	Filamentation induced by cAMP protein fic
E4O06_RS11205	COG1120	ATPase activity
E4O06_RS11235	COG0534	Mate efflux family protein
E4O06_RS11255	COG1132	(ABC) transporter
E4O06_RS11260	COG0488	(ABC) transporter
E4O06_RS11275	COG1192	Involved in chromosome partitioning
E4O06_RS11280	COG1475	DNA binding
E4O06_RS11315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4O06_RS11320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4O06_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
E4O06_RS11335	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4O06_RS11390	COG0439	Biotin carboxylase
E4O06_RS11395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4O06_RS11400	COG0825	malonyl-CoA metabolic process
E4O06_RS11405	COG2986	histidine ammonia-lyase
E4O06_RS11420	COG0701	Predicted permease
E4O06_RS11430	COG0714	Associated with various cellular activities
E4O06_RS11465	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O06_RS11470	COG0154	amidase activity
E4O06_RS11475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O06_RS11770	COG2887	Belongs to the helicase family. UvrD subfamily
E4O06_RS11775	COG0569	domain protein
E4O06_RS11780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O06_RS11785	COG1305	Transglutaminase-like
E4O06_RS11800	COG0215	cysteine-tRNA ligase activity
E4O06_RS11805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4O06_RS11815	COG1373	ATPase (AAA superfamily
E4O06_RS11845	COG1506	peptidase
E4O06_RS11845	COG4946	Tricorn protease homolog
E4O06_RS11845	COG0823	Involved in the tonB-independent uptake of proteins
E4O06_RS11860	COG1104	cysteine desulfurase activity
E4O06_RS11865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4O06_RS11870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4O06_RS11905	COG0747	negative chemotaxis
E4O06_RS11910	COG4608	Belongs to the ABC transporter superfamily
E4O06_RS11915	COG0444	Belongs to the ABC transporter superfamily
E4O06_RS11920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O06_RS11935	COG1840	ABC-type Fe3 transport system, periplasmic component
E4O06_RS11940	COG4133	protoheme IX ABC transporter activity
E4O06_RS11950	COG3842	ATPase activity
E4O06_RS11955	COG0438	transferase activity, transferring glycosyl groups
E4O06_RS11975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4O06_RS11990	COG4988	ABC transporter
E4O06_RS12015	COG0728	peptidoglycan biosynthetic process
E4O06_RS12020	COG0786	glutamate:sodium symporter activity
E4O06_RS12030	COG0840	transmembrane signaling receptor activity
E4O06_RS12035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O06_RS12040	COG3588	fructose-bisphosphate aldolase
E4O06_RS12050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O06_RS12100	COG0569	domain protein
E4O06_RS12105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4O06_RS12110	COG0363	glucosamine-6-phosphate deaminase activity
E4O06_RS12115	COG0628	permease
E4O06_RS12120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O06_RS12130	COG1902	pentaerythritol trinitrate reductase activity
E4O06_RS12135	COG1595	DNA-templated transcription, initiation
E4O06_RS12155	COG0534	Mate efflux family protein
E4O06_RS12160	COG1309	transcriptional regulator
E4O06_RS12170	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4O06_RS12175	COG1518	maintenance of DNA repeat elements
E4O06_RS12190	COG0514	ATP-dependent DNA helicase (RecQ)
E4O06_RS12205	COG4536	flavin adenine dinucleotide binding
E4O06_RS12210	COG4536	flavin adenine dinucleotide binding
E4O06_RS12215	COG0714	Associated with various cellular activities
E4O06_RS12225	COG0569	domain protein
E4O06_RS12230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O06_RS12235	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4O06_RS12280	COG1136	(ABC) transporter
E4O06_RS12295	COG0616	signal peptide processing
E4O06_RS12300	COG0012	GTP binding
E4O06_RS12360	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4O06_RS12375	COG3839	Belongs to the ABC transporter superfamily
E4O06_RS12380	COG4208	sulfate ABC transporter
E4O06_RS12405	COG0730	response to heat
E4O06_RS12465	COG1132	(ABC) transporter
E4O06_RS12475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4O06_RS12490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4O06_RS12510	COG1929	Belongs to the glycerate kinase type-1 family
E4O06_RS12515	COG3152	Membrane
E4O06_RS12520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4O06_RS12625	COG1487	ribonuclease activity
E4O06_RS12660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4O06_RS12665	COG0592	DNA-directed DNA polymerase activity
E4O06_RS12670	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4O06_RS12675	COG3177	Filamentation induced by cAMP protein fic
E4O06_RS12690	COG1418	mRNA catabolic process
E4O06_RS12710	COG1968	undecaprenyl-diphosphatase activity
E4O06_RS12715	COG1674	ftsk spoiiie
E4O06_RS12720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4O06_RS12725	COG3706	GGDEF domain
E4O06_RS12730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4O06_RS12735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O06_RS12795	COG0813	purine-nucleoside phosphorylase activity
E4O06_RS12825	COG0840	transmembrane signaling receptor activity
E4O06_RS12855	COG4221	oxidoreductase activity
E4O06_RS12860	COG0789	Transcriptional regulator
E4O06_RS12905	COG0789	Transcriptional regulator
E4O06_RS12920	COG3586	endonuclease activity
E4O06_RS12935	COG1132	(ABC) transporter
E4O06_RS12940	COG1132	(ABC) transporter
E4O06_RS12945	COG1129	ABC transporter
E4O06_RS12960	COG0419	ATPase involved in DNA repair
E4O06_RS12965	COG0420	3'-5' exonuclease activity
E4O06_RS12970	COG3290	protein histidine kinase activity
E4O06_RS12970	COG0840	transmembrane signaling receptor activity
E4O06_RS12980	COG1131	(ABC) transporter
E4O06_RS12990	COG1132	(ABC) transporter
E4O06_RS12995	COG2345	Transcriptional regulator
E4O06_RS13020	COG0500	methyltransferase
E4O06_RS13035	COG1132	(ABC) transporter
E4O06_RS13060	COG2186	Transcriptional regulator
E4O06_RS13070	COG1132	(ABC) transporter
E4O06_RS13080	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O06_RS13170	COG1373	ATPase (AAA superfamily
E4O06_RS13175	COG1473	amidohydrolase
E4O06_RS13185	COG4585	Histidine kinase
E4O06_RS13210	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O06_RS13235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4O06_RS13240	COG1487	ribonuclease activity
E4O06_RS13260	COG0716	FMN binding
E4O06_RS13270	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4O06_RS13270	COG0540	Belongs to the ATCase OTCase family
E4O06_RS13275	COG5002	protein histidine kinase activity
E4O06_RS13275	COG5001	Diguanylate cyclase
E4O06_RS13305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4O06_RS13335	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4O06_RS13350	COG1774	PSP1 C-terminal conserved region
E4O06_RS13355	COG1728	Protein conserved in bacteria
E4O06_RS13365	COG0739	heme binding
E4O06_RS13375	COG0366	Alpha amylase catalytic
E4O06_RS13385	COG1609	Transcriptional regulator
E4O06_RS13390	COG1129	ABC transporter
E4O06_RS13415	COG0543	2 iron, 2 sulfur cluster binding
E4O06_RS13425	COG4783	chaperone-mediated protein folding
E4O06_RS13430	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4O06_RS13515	COG1592	Rubrerythrin
E4O06_RS13520	COG0514	ATP-dependent DNA helicase (RecQ)
E4O06_RS13535	COG1381	Involved in DNA repair and RecF pathway recombination
E4O06_RS13545	COG0343	queuine tRNA-ribosyltransferase activity
E4O06_RS13610	COG1695	Transcriptional regulator
E4O06_RS13620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4O06_RS13640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4O06_RS13650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O06_RS13670	COG1228	amidohydrolase
E4O06_RS13680	COG1987	bacterial-type flagellum assembly
E4O06_RS13685	COG1684	flagellar biosynthetic protein fliR
E4O06_RS13690	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O06_RS13695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O06_RS13715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O06_RS13725	COG3328	transposase activity
E4O06_RS13770	COG0205	6-phosphofructokinase activity
E4O06_RS13785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O06_RS13800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O06_RS13805	COG1509	lysine 2,3-aminomutase activity
E4O06_RS13810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O06_RS13815	COG0826	peptidase U32
E4O06_RS13840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O06_RS13865	COG2801	Transposase and inactivated derivatives
E4O06_RS13980	COG4555	ABC transporter
E4O06_RS13995	COG0840	transmembrane signaling receptor activity
E4O06_RS14020	COG1151	hydroxylamine reductase activity
E4O06_RS14040	COG0577	efflux transmembrane transporter activity
E4O06_RS14040	COG1136	(ABC) transporter
E4O06_RS14080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4O06_RS14110	COG0813	purine-nucleoside phosphorylase activity
E4O06_RS14120	COG0840	transmembrane signaling receptor activity
E4O06_RS14135	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4O06_RS14140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O06_RS14145	COG0037	tRNA processing
E4O06_RS14160	COG2235	arginine
E4O06_RS14170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4O06_RS14180	COG2217	Heavy metal translocating P-type atpase
E4O06_RS14190	COG0494	nUDIX hydrolase
E4O06_RS14195	COG0783	Belongs to the Dps family
E4O06_RS14200	COG0450	alkyl hydroperoxide reductase
E4O06_RS14205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4O06_RS14225	COG1363	Peptidase, m42
E4O06_RS14235	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4O06_RS14240	COG0423	glycine-tRNA ligase activity
E4O06_RS14260	COG1472	Belongs to the glycosyl hydrolase 3 family
E4O06_RS14315	COG0537	adenosine 5'-monophosphoramidase activity
E4O06_RS14335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4O06_RS14345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4O06_RS14350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E4O06_RS14350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E4O06_RS14355	COG0280	phosphate acetyltransferase
E4O06_RS14360	COG0457	Tetratricopeptide repeat
E4O06_RS14365	COG1393	Belongs to the ArsC family
E4O06_RS14370	COG0488	(ABC) transporter
E4O06_RS14405	COG0187	DNA topoisomerase II activity
E4O06_RS14445	COG3209	COG3209 Rhs family protein