locus-tag	class	description
E4O07_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4O07_RS00020	COG0587	DNA-directed DNA polymerase activity
E4O07_RS00045	COG1132	(ABC) transporter
E4O07_RS00050	COG1132	(ABC) transporter
E4O07_RS00095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O07_RS00100	COG1120	ATPase activity
E4O07_RS00105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4O07_RS00125	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4O07_RS00130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4O07_RS00135	COG2986	histidine ammonia-lyase
E4O07_RS00170	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4O07_RS00185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4O07_RS00190	COG1360	Flagellar Motor Protein
E4O07_RS00195	COG1580	Controls the rotational direction of flagella during chemotaxis
E4O07_RS00200	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O07_RS00205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O07_RS00205	COG1776	CheC inhibitor of MCP methylation
E4O07_RS00215	COG1338	Plays a role in the flagellum-specific transport system
E4O07_RS00220	COG4166	transmembrane transport
E4O07_RS00225	COG2423	ornithine cyclodeaminase activity
E4O07_RS00230	COG0739	heme binding
E4O07_RS00235	COG4545	Glutaredoxin-related protein
E4O07_RS00265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4O07_RS00290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4O07_RS00290	COG3116	cell division
E4O07_RS00295	COG0084	hydrolase, TatD family'
E4O07_RS00305	COG1373	ATPase (AAA superfamily
E4O07_RS00310	COG2203	Gaf domain
E4O07_RS00310	COG2199	diguanylate cyclase activity
E4O07_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4O07_RS00325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O07_RS00360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4O07_RS00370	COG2239	Acts as a magnesium transporter
E4O07_RS00380	COG0546	phosphoglycolate phosphatase activity
E4O07_RS00385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4O07_RS00415	COG2211	Major facilitator Superfamily
E4O07_RS00455	COG0396	ATPase activity
E4O07_RS00460	COG0719	Fe-S assembly protein
E4O07_RS00470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4O07_RS00480	COG2361	Protein of unknown function DUF86
E4O07_RS00530	COG0425	Belongs to the sulfur carrier protein TusA family
E4O07_RS00540	COG1104	cysteine desulfurase activity
E4O07_RS00545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O07_RS00550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O07_RS00555	COG1862	Preprotein translocase
E4O07_RS00560	COG0629	single-stranded DNA binding
E4O07_RS00565	COG0300	oxidoreductase activity
E4O07_RS00570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4O07_RS00575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4O07_RS00590	COG0482	sulfurtransferase activity
E4O07_RS00600	COG0351	phosphomethylpyrimidine kinase
E4O07_RS00605	COG1131	(ABC) transporter
E4O07_RS00635	COG0330	HflC and HflK could
E4O07_RS00675	COG1086	Polysaccharide biosynthesis protein
E4O07_RS00735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4O07_RS00785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4O07_RS00835	COG3118	belongs to the thioredoxin family
E4O07_RS00845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4O07_RS00890	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4O07_RS00895	COG0135	phosphoribosylanthranilate isomerase activity
E4O07_RS00900	COG1757	Na H antiporter
E4O07_RS00905	COG1120	ATPase activity
E4O07_RS00910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O07_RS00935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4O07_RS00940	COG0051	transcription antitermination factor activity, RNA binding
E4O07_RS00945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4O07_RS00950	COG0088	Forms part of the polypeptide exit tunnel
E4O07_RS00955	COG0089	rRNA binding
E4O07_RS00960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4O07_RS00965	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4O07_RS00970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4O07_RS00975	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4O07_RS00980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4O07_RS00985	COG0255	Belongs to the universal ribosomal protein uL29 family
E4O07_RS00990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4O07_RS00995	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4O07_RS01000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4O07_RS01005	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4O07_RS01010	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4O07_RS01015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4O07_RS01020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4O07_RS01025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4O07_RS01030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4O07_RS01035	COG1841	ribosomal large subunit assembly
E4O07_RS01040	COG0200	Binds to the 23S rRNA
E4O07_RS01050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4O07_RS01055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4O07_RS01060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4O07_RS01065	COG0202	RNA polymerase activity
E4O07_RS01070	COG0203	ribosomal protein L17
E4O07_RS01090	COG1254	Belongs to the acylphosphatase family
E4O07_RS01115	COG1959	2 iron, 2 sulfur cluster binding
E4O07_RS01120	COG2910	NAD(P)H-binding
E4O07_RS01140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4O07_RS01145	COG1690	Belongs to the RtcB family
E4O07_RS01260	COG3039	Transposase
E4O07_RS01265	COG1131	(ABC) transporter
E4O07_RS01280	COG0640	Transcriptional regulator
E4O07_RS01285	COG4942	peptidase
E4O07_RS01325	COG2274	protein secretion by the type I secretion system
E4O07_RS01330	COG1132	(ABC) transporter
E4O07_RS01340	COG1741	Belongs to the pirin family
E4O07_RS01360	COG1288	antiporter activity
E4O07_RS01365	COG1473	amidohydrolase
E4O07_RS01375	COG1132	(ABC) transporter
E4O07_RS01380	COG1132	(ABC) transporter
E4O07_RS01395	COG1132	(ABC) transporter
E4O07_RS01400	COG1129	ABC transporter
E4O07_RS01420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4O07_RS01430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4O07_RS01435	COG1070	Carbohydrate kinase
E4O07_RS01440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4O07_RS01445	COG0626	cystathionine gamma-synthase activity
E4O07_RS01460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4O07_RS01470	COG0445	tRNA wobble uridine modification
E4O07_RS01475	COG1362	aminopeptidase activity
E4O07_RS01485	COG4657	Part of a membrane complex involved in electron transport
E4O07_RS01490	COG4660	Part of a membrane complex involved in electron transport
E4O07_RS01495	COG4659	FMN binding
E4O07_RS01500	COG4658	electron transport chain
E4O07_RS01505	COG4656	Part of a membrane complex involved in electron transport
E4O07_RS01510	COG1054	Belongs to the UPF0176 family
E4O07_RS01520	COG2304	oxidoreductase activity
E4O07_RS01535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O07_RS01535	COG0574	Belongs to the PEP-utilizing enzyme family
E4O07_RS01545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4O07_RS01580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4O07_RS01595	COG2197	response regulator
E4O07_RS01620	COG1187	pseudouridine synthase activity
E4O07_RS01625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4O07_RS01640	COG1285	pathogenesis
E4O07_RS01670	COG5433	transposase activity
E4O07_RS01680	COG0737	Belongs to the 5'-nucleotidase family
E4O07_RS01685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4O07_RS01690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4O07_RS01695	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4O07_RS01715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4O07_RS01730	COG0228	four-way junction DNA binding
E4O07_RS01735	COG1837	Belongs to the UPF0109 family
E4O07_RS01740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4O07_RS01745	COG0336	Belongs to the RNA methyltransferase TrmD family
E4O07_RS01750	COG0335	large ribosomal subunit rRNA binding
E4O07_RS01765	COG0210	DNA helicase
E4O07_RS01775	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O07_RS01790	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4O07_RS01795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4O07_RS01800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O07_RS01805	COG0534	Mate efflux family protein
E4O07_RS01815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4O07_RS01820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O07_RS01835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4O07_RS01840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O07_RS01850	COG3735	TraB family
E4O07_RS01860	COG0791	NLP P60 protein
E4O07_RS01865	COG0318	PFAM AMP-dependent synthetase and ligase
E4O07_RS01885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O07_RS01895	COG0148	phosphopyruvate hydratase activity
E4O07_RS01920	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4O07_RS01930	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4O07_RS01940	COG4585	Histidine kinase
E4O07_RS01955	COG1131	(ABC) transporter
E4O07_RS01960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4O07_RS01980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4O07_RS01995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4O07_RS02015	COG0411	ABC transporter
E4O07_RS02035	COG2376	Dihydroxyacetone kinase
E4O07_RS02040	COG2376	Dihydroxyacetone kinase
E4O07_RS02050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O07_RS02060	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4O07_RS02065	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4O07_RS02070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O07_RS02090	COG1413	lyase activity
E4O07_RS02095	COG0424	maF-like protein
E4O07_RS02100	COG0052	Belongs to the universal ribosomal protein uS2 family
E4O07_RS02105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4O07_RS02110	COG0233	cytoplasmic translational termination
E4O07_RS02115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4O07_RS02120	COG0575	Belongs to the CDS family
E4O07_RS02125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4O07_RS02130	COG0750	zinc metalloprotease
E4O07_RS02140	COG0495	leucyl-tRNA aminoacylation
E4O07_RS02150	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4O07_RS02155	COG1132	(ABC) transporter
E4O07_RS02160	COG1132	(ABC) transporter
E4O07_RS02165	COG0210	DNA helicase
E4O07_RS02185	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4O07_RS02190	COG0542	response to heat
E4O07_RS02225	COG2197	response regulator
E4O07_RS02230	COG0668	transmembrane transport
E4O07_RS02245	COG1595	DNA-templated transcription, initiation
E4O07_RS02255	COG0739	heme binding
E4O07_RS02255	COG0741	lytic transglycosylase activity
E4O07_RS02255	COG1196	nuclear chromosome segregation
E4O07_RS02260	COG1272	protein, Hemolysin III
E4O07_RS02285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4O07_RS02290	COG3604	Transcriptional regulator
E4O07_RS02310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4O07_RS02325	COG0792	nuclease activity
E4O07_RS02335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O07_RS02340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O07_RS02350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O07_RS02365	COG0668	transmembrane transport
E4O07_RS02375	COG0546	phosphoglycolate phosphatase activity
E4O07_RS02385	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O07_RS02390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4O07_RS02390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O07_RS02400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O07_RS02405	COG0545	Peptidyl-prolyl cis-trans isomerase
E4O07_RS02410	COG3956	TIGRFAM MazG family protein
E4O07_RS02425	COG2801	Transposase and inactivated derivatives
E4O07_RS02460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4O07_RS02475	COG3142	Participates in the control of copper homeostasis
E4O07_RS02485	COG4865	methylaspartate mutase activity
E4O07_RS02500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O07_RS02505	COG1120	ATPase activity
E4O07_RS02520	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O07_RS02530	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O07_RS02550	COG0442	prolyl-tRNA aminoacylation
E4O07_RS02570	COG1879	ABC-type sugar transport system periplasmic component
E4O07_RS02575	COG1129	ABC transporter
E4O07_RS02580	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4O07_RS02585	COG2226	methyltransferase
E4O07_RS02600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O07_RS02610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4O07_RS02630	COG2056	Na+-H+ antiporter family
E4O07_RS02635	COG1757	Na H antiporter
E4O07_RS02650	COG0626	cystathionine gamma-synthase activity
E4O07_RS02655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4O07_RS02660	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O07_RS02660	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O07_RS02660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O07_RS02660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O07_RS02670	COG0564	pseudouridine synthase activity
E4O07_RS02675	COG0156	8-amino-7-oxononanoate synthase activity
E4O07_RS02695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4O07_RS02695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4O07_RS02700	COG0739	heme binding
E4O07_RS02710	COG1475	DNA binding
E4O07_RS02715	COG1022	Amp-dependent synthetase and ligase
E4O07_RS02745	COG0671	phosphoesterase, PA-phosphatase related
E4O07_RS02750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4O07_RS02785	COG2226	methyltransferase
E4O07_RS02815	COG2738	Putative neutral zinc metallopeptidase
E4O07_RS02825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4O07_RS02840	COG1129	ABC transporter
E4O07_RS02890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4O07_RS02895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4O07_RS02905	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4O07_RS02910	COG1671	Belongs to the UPF0178 family
E4O07_RS02920	COG0741	lytic transglycosylase activity
E4O07_RS02920	COG1388	LysM domain
E4O07_RS02945	COG3681	Belongs to the UPF0597 family
E4O07_RS02950	COG4953	penicillin-binding protein 1C
E4O07_RS02955	COG5433	transposase activity
E4O07_RS02960	COG1770	oligopeptidase
E4O07_RS02995	COG1122	ATPase activity
E4O07_RS03015	COG1487	ribonuclease activity
E4O07_RS03035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4O07_RS03075	COG2770	Histidine kinase
E4O07_RS03075	COG2208	phosphoserine phosphatase activity
E4O07_RS03080	COG1131	(ABC) transporter
E4O07_RS03100	COG0284	orotidine-5'-phosphate decarboxylase activity
E4O07_RS03120	COG0513	Belongs to the DEAD box helicase family
E4O07_RS03130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4O07_RS03175	COG3876	Protein conserved in bacteria
E4O07_RS03180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4O07_RS03195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4O07_RS03200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4O07_RS03205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4O07_RS03210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4O07_RS03215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4O07_RS03220	COG0484	heat shock protein binding
E4O07_RS03225	COG0528	UMP kinase activity
E4O07_RS03230	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4O07_RS03250	COG2204	response regulator
E4O07_RS03255	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4O07_RS03275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4O07_RS03300	COG0251	oxidation-reduction process
E4O07_RS03305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4O07_RS03310	COG1722	exodeoxyribonuclease VII activity
E4O07_RS03330	COG1918	ferrous iron import across plasma membrane
E4O07_RS03335	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4O07_RS03335	COG1918	ferrous iron import across plasma membrane
E4O07_RS03380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O07_RS03420	COG4166	transmembrane transport
E4O07_RS03450	COG0552	protein localization to endoplasmic reticulum
E4O07_RS03460	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4O07_RS03465	COG1136	(ABC) transporter
E4O07_RS03475	COG3880	PFAM UvrB UvrC protein
E4O07_RS03480	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4O07_RS03490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4O07_RS03500	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4O07_RS03500	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4O07_RS03510	COG0084	hydrolase, TatD family'
E4O07_RS03515	COG2885	chlorophyll binding
E4O07_RS03600	COG3039	Transposase
E4O07_RS03695	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O07_RS03705	COG1288	antiporter activity
E4O07_RS03730	COG1233	COG1233 Phytoene dehydrogenase and related
E4O07_RS03740	COG0170	dolichyl monophosphate biosynthetic process
E4O07_RS03745	COG1164	Oligoendopeptidase f
E4O07_RS03750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O07_RS03755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4O07_RS03760	COG0606	chelatase, subunit chli
E4O07_RS03780	COG1199	ATP-dependent helicase activity
E4O07_RS03790	COG0823	Involved in the tonB-independent uptake of proteins
E4O07_RS03805	COG4254	PFAM FecR protein
E4O07_RS03850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4O07_RS03855	COG1286	toxin biosynthetic process
E4O07_RS03860	COG0470	DNA polymerase III
E4O07_RS03865	COG3852	Histidine kinase
E4O07_RS03870	COG2204	response regulator
E4O07_RS03875	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4O07_RS03890	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4O07_RS03910	COG1234	tRNA 3'-trailer cleavage
E4O07_RS03915	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O07_RS03920	COG3845	ABC transporter
E4O07_RS03925	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O07_RS03930	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O07_RS03960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4O07_RS03990	COG0295	cytidine deaminase activity
E4O07_RS04030	COG1047	Peptidyl-prolyl cis-trans
E4O07_RS04045	COG0731	radical SAM domain protein
E4O07_RS04060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O07_RS04065	COG1979	alcohol dehydrogenase
E4O07_RS04070	COG2255	four-way junction helicase activity
E4O07_RS04080	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4O07_RS04095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4O07_RS04110	COG0736	holo-[acyl-carrier-protein] synthase activity
E4O07_RS04125	COG1725	Transcriptional regulator
E4O07_RS04130	COG0653	protein targeting
E4O07_RS04135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4O07_RS04140	COG0138	bifunctional purine biosynthesis protein purh
E4O07_RS04145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4O07_RS04150	COG2878	Part of a membrane complex involved in electron transport
E4O07_RS04160	COG0481	GTPase activity
E4O07_RS04165	COG1114	Component of the transport system for branched-chain amino acids
E4O07_RS04180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O07_RS04195	COG2723	6-phospho-beta-galactosidase activity
E4O07_RS04215	COG0488	(ABC) transporter
E4O07_RS04225	COG0793	Belongs to the peptidase S41A family
E4O07_RS04260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4O07_RS04265	COG0632	four-way junction helicase activity
E4O07_RS04305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4O07_RS04315	COG1136	(ABC) transporter
E4O07_RS04320	COG0577	efflux transmembrane transporter activity
E4O07_RS04320	COG1136	(ABC) transporter
E4O07_RS04430	COG0596	Alpha beta hydrolase
E4O07_RS04635	COG5433	transposase activity
E4O07_RS04710	COG2226	methyltransferase
E4O07_RS04725	COG0406	alpha-ribazole phosphatase activity
E4O07_RS04735	COG1418	mRNA catabolic process
E4O07_RS04760	COG2033	superoxide reductase activity
E4O07_RS04765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4O07_RS04775	COG2720	vancomycin resistance protein
E4O07_RS04780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4O07_RS04790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4O07_RS04795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4O07_RS04810	COG0799	negative regulation of ribosome biogenesis
E4O07_RS04815	COG2059	Chromate
E4O07_RS04860	COG0739	heme binding
E4O07_RS04870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O07_RS04880	COG0708	Exodeoxyribonuclease III
E4O07_RS04885	COG0024	Methionine aminopeptidase
E4O07_RS04890	COG0484	heat shock protein binding
E4O07_RS04895	COG3250	beta-galactosidase activity
E4O07_RS04920	COG0617	tRNA 3'-terminal CCA addition
E4O07_RS04935	COG0519	Catalyzes the synthesis of GMP from XMP
E4O07_RS04945	COG0126	phosphoglycerate kinase activity
E4O07_RS04950	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4O07_RS04970	COG0268	Binds directly to 16S ribosomal RNA
E4O07_RS04975	COG0776	regulation of translation
E4O07_RS04980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4O07_RS04990	COG1546	Belongs to the CinA family
E4O07_RS04990	COG1058	Belongs to the CinA family
E4O07_RS05015	COG0588	phosphoglycerate mutase activity
E4O07_RS05035	COG1131	(ABC) transporter
E4O07_RS05045	COG0457	Tetratricopeptide repeat
E4O07_RS05050	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4O07_RS05055	COG2203	Gaf domain
E4O07_RS05055	COG5001	Diguanylate cyclase
E4O07_RS05055	COG3706	GGDEF domain
E4O07_RS05055	COG4251	negative regulation of phosphorylation
E4O07_RS05060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4O07_RS05065	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4O07_RS05070	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4O07_RS05075	COG1394	ATPase activity, coupled to movement of substances
E4O07_RS05080	COG1269	ATP hydrolysis coupled proton transport
E4O07_RS05090	COG0360	Binds together with S18 to 16S ribosomal RNA
E4O07_RS05095	COG0629	single-stranded DNA binding
E4O07_RS05100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4O07_RS05105	COG0359	binds to the 23S rRNA
E4O07_RS05115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4O07_RS05120	COG0740	serine-type endopeptidase activity
E4O07_RS05125	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4O07_RS05145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O07_RS05155	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4O07_RS05175	COG0305	Participates in initiation and elongation during chromosome replication
E4O07_RS05190	COG2801	Transposase and inactivated derivatives
E4O07_RS05205	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4O07_RS05210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4O07_RS05215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4O07_RS05240	COG1132	(ABC) transporter
E4O07_RS05245	COG1132	(ABC) transporter
E4O07_RS05250	COG1268	BioY protein
E4O07_RS05255	COG1122	ATPase activity
E4O07_RS05260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E4O07_RS05280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O07_RS05295	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4O07_RS05300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4O07_RS05310	COG0237	dephospho-CoA kinase activity
E4O07_RS05315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O07_RS05315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O07_RS05315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O07_RS05320	COG3052	prosthetic group binding
E4O07_RS05345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4O07_RS05350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4O07_RS05355	COG0509	glycine decarboxylation via glycine cleavage system
E4O07_RS05360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O07_RS05365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O07_RS05395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4O07_RS05415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4O07_RS05445	COG1061	Type III restriction enzyme res subunit
E4O07_RS05470	COG1715	Restriction endonuclease
E4O07_RS05480	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4O07_RS05485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O07_RS05485	COG0493	'glutamate synthase
E4O07_RS05495	COG0488	(ABC) transporter
E4O07_RS05500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4O07_RS05510	COG0835	chemotaxis
E4O07_RS05520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4O07_RS05535	COG0297	glycogen (starch) synthase activity
E4O07_RS05540	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4O07_RS05545	COG2982	Protein involved in outer membrane biogenesis
E4O07_RS05570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O07_RS05575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4O07_RS05580	COG0095	Lipoate-protein ligase
E4O07_RS05585	COG4608	Belongs to the ABC transporter superfamily
E4O07_RS05590	COG0444	Belongs to the ABC transporter superfamily
E4O07_RS05595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O07_RS05600	COG0601	transmembrane transport
E4O07_RS05605	COG0747	negative chemotaxis
E4O07_RS05610	COG0205	6-phosphofructokinase activity
E4O07_RS05615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4O07_RS05620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4O07_RS05625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4O07_RS05645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4O07_RS05660	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4O07_RS05680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4O07_RS05690	COG0142	geranyltranstransferase activity
E4O07_RS05700	COG1692	metallophosphoesterase
E4O07_RS05725	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4O07_RS05755	COG1136	(ABC) transporter
E4O07_RS05760	COG0577	efflux transmembrane transporter activity
E4O07_RS05775	COG3470	protein probably involved in high-affinity Fe2 transport
E4O07_RS05780	COG0672	)-iron permease
E4O07_RS05785	COG1136	(ABC) transporter
E4O07_RS05795	COG1760	l-serine dehydratase
E4O07_RS05800	COG1760	l-serine dehydratase
E4O07_RS05810	COG0254	rRNA binding
E4O07_RS05815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4O07_RS05830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O07_RS05830	COG0574	Belongs to the PEP-utilizing enzyme family
E4O07_RS05840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4O07_RS05885	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O07_RS05895	COG1196	nuclear chromosome segregation
E4O07_RS05905	COG2201	protein-glutamate methylesterase activity
E4O07_RS05915	COG0835	chemotaxis
E4O07_RS05920	COG0643	Histidine kinase
E4O07_RS05920	COG2198	Histidine kinase
E4O07_RS05935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4O07_RS05940	COG0217	transcriptional regulatory protein
E4O07_RS05975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O07_RS05980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O07_RS05990	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4O07_RS05990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4O07_RS06005	COG0802	atpase or kinase
E4O07_RS06015	COG2770	Histidine kinase
E4O07_RS06015	COG3437	response regulator, receiver
E4O07_RS06020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4O07_RS06030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4O07_RS06040	COG0009	L-threonylcarbamoyladenylate synthase
E4O07_RS06085	COG1136	(ABC) transporter
E4O07_RS06095	COG3292	Two component regulator propeller
E4O07_RS06095	COG0745	RESPONSE REGULATOR receiver
E4O07_RS06095	COG2205	protein histidine kinase activity
E4O07_RS06100	COG0745	RESPONSE REGULATOR receiver
E4O07_RS06110	COG2190	(PTS) system
E4O07_RS06110	COG2211	Major facilitator Superfamily
E4O07_RS06120	COG1193	negative regulation of DNA recombination
E4O07_RS06125	COG1162	GTPase activity
E4O07_RS06135	COG1132	(ABC) transporter
E4O07_RS06145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O07_RS06160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4O07_RS06170	COG0124	histidyl-tRNA synthetase
E4O07_RS06185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O07_RS06190	COG0297	glycogen (starch) synthase activity
E4O07_RS06200	COG0706	membrane insertase activity
E4O07_RS06205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4O07_RS06225	COG0463	Glycosyl transferase, family 2
E4O07_RS06230	COG3306	glycosyltransferase involved in LPS biosynthesis
E4O07_RS06255	COG1215	transferase activity, transferring glycosyl groups
E4O07_RS06290	COG1215	transferase activity, transferring glycosyl groups
E4O07_RS06325	COG1373	ATPase (AAA superfamily
E4O07_RS06330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4O07_RS06335	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4O07_RS06335	COG0028	Belongs to the TPP enzyme family
E4O07_RS06355	COG0475	glutathione-regulated potassium exporter activity
E4O07_RS06380	COG1078	dGTPase activity
E4O07_RS06390	COG0047	phosphoribosylformylglycinamidine synthase activity
E4O07_RS06400	COG0488	(ABC) transporter
E4O07_RS06410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4O07_RS06410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4O07_RS06415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4O07_RS06450	COG4658	electron transport chain
E4O07_RS06455	COG4656	Part of a membrane complex involved in electron transport
E4O07_RS06490	COG2217	Heavy metal translocating P-type atpase
E4O07_RS06495	COG0640	Transcriptional regulator
E4O07_RS06500	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4O07_RS06515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4O07_RS06535	COG0557	exoribonuclease II activity
E4O07_RS06540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4O07_RS06540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4O07_RS06545	COG0556	nucleotide-excision repair
E4O07_RS06550	COG1136	(ABC) transporter
E4O07_RS06610	COG4555	ABC transporter
E4O07_RS06620	COG1132	(ABC) transporter
E4O07_RS06625	COG0535	radical SAM domain protein
E4O07_RS06660	COG2378	regulation of single-species biofilm formation
E4O07_RS06665	COG0525	valine-tRNA ligase activity
E4O07_RS06670	COG2252	PERMEase
E4O07_RS06680	COG2017	converts alpha-aldose to the beta-anomer
E4O07_RS06695	COG0772	Belongs to the SEDS family
E4O07_RS06700	COG0768	penicillin binding
E4O07_RS06715	COG1077	Cell shape determining protein MreB Mrl
E4O07_RS06735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O07_RS06740	COG0358	DNA primase activity
E4O07_RS06760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O07_RS06765	COG0457	Tetratricopeptide repeat
E4O07_RS06770	COG0037	tRNA processing
E4O07_RS06775	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4O07_RS06785	COG2088	sporulation resulting in formation of a cellular spore
E4O07_RS06790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4O07_RS06810	COG0330	HflC and HflK could
E4O07_RS06815	COG0330	HflC and HflK could
E4O07_RS06825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4O07_RS06850	COG1739	Uncharacterized protein family UPF0029
E4O07_RS06875	COG2604	Protein of unknown function DUF115
E4O07_RS06880	COG0768	penicillin binding
E4O07_RS06890	COG0433	COG0433 Predicted ATPase
E4O07_RS06905	COG0312	modulator of DNA gyrase
E4O07_RS06910	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4O07_RS06930	COG0497	DNA recombination
E4O07_RS06950	COG0791	NLP P60 protein
E4O07_RS06950	COG1388	LysM domain
E4O07_RS06960	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4O07_RS06965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O07_RS06970	COG0312	modulator of DNA gyrase
E4O07_RS06975	COG0312	modulator of DNA gyrase
E4O07_RS06995	COG1122	ATPase activity
E4O07_RS07015	COG0840	transmembrane signaling receptor activity
E4O07_RS07125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4O07_RS07130	COG4475	Protein of unknown function (DUF436)
E4O07_RS07160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4O07_RS07165	COG3118	belongs to the thioredoxin family
E4O07_RS07180	COG4750	Nucleotidyl transferase
E4O07_RS07185	COG1115	amino acid carrier protein
E4O07_RS07205	COG1193	negative regulation of DNA recombination
E4O07_RS07255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4O07_RS07260	COG1480	7TM receptor with intracellular HD hydrolase
E4O07_RS07265	COG1702	phosphate starvation-inducible protein PhoH
E4O07_RS07280	COG0149	triose-phosphate isomerase activity
E4O07_RS07305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O07_RS07325	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O07_RS07330	COG1121	(ABC) transporter
E4O07_RS07335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O07_RS07340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O07_RS07365	COG1157	protein secretion by the type III secretion system
E4O07_RS07370	COG1317	bacterial-type flagellum organization
E4O07_RS07380	COG1766	The M ring may be actively involved in energy transduction
E4O07_RS07385	COG1677	Flagellar hook-basal body complex protein FliE
E4O07_RS07400	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4O07_RS07405	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4O07_RS07410	COG4974	Belongs to the 'phage' integrase family
E4O07_RS07415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4O07_RS07415	COG0551	DNA topoisomerase type I activity
E4O07_RS07420	COG0758	DNA mediated transformation
E4O07_RS07430	COG4974	Belongs to the 'phage' integrase family
E4O07_RS07435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4O07_RS07450	COG0772	Belongs to the SEDS family
E4O07_RS07455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4O07_RS07465	COG0275	rRNA processing
E4O07_RS07470	COG2001	Belongs to the MraZ family
E4O07_RS07475	COG1505	serine-type exopeptidase activity
E4O07_RS07510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4O07_RS07520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4O07_RS07535	COG0459	protein refolding
E4O07_RS07550	COG4974	Belongs to the 'phage' integrase family
E4O07_RS07605	COG1475	DNA binding
E4O07_RS07740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4O07_RS07745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4O07_RS07785	COG1366	Belongs to the anti-sigma-factor antagonist family
E4O07_RS07805	COG3033	Beta-eliminating lyase
E4O07_RS07825	COG0826	peptidase U32
E4O07_RS07835	COG1132	(ABC) transporter
E4O07_RS07840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4O07_RS07855	COG0101	tRNA pseudouridine synthase activity
E4O07_RS07865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4O07_RS07870	COG1639	'signal transduction protein
E4O07_RS07885	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4O07_RS07890	COG0577	efflux transmembrane transporter activity
E4O07_RS07890	COG1136	(ABC) transporter
E4O07_RS07895	COG1136	(ABC) transporter
E4O07_RS07915	COG2801	Transposase and inactivated derivatives
E4O07_RS07925	COG0563	adenylate kinase activity
E4O07_RS07945	COG0779	Required for maturation of 30S ribosomal subunits
E4O07_RS07955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4O07_RS07960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4O07_RS07965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4O07_RS07995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4O07_RS08000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4O07_RS08010	COG3330	Domain of unknown function (DUF4912)
E4O07_RS08025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O07_RS08035	COG3706	GGDEF domain
E4O07_RS08040	COG1102	Psort location Cytoplasmic, score
E4O07_RS08045	COG1561	YicC-like family, N-terminal region
E4O07_RS08055	COG0285	dihydrofolate synthase activity
E4O07_RS08075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4O07_RS08080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O07_RS08085	COG0426	domain, Protein
E4O07_RS08085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4O07_RS08090	COG4608	Belongs to the ABC transporter superfamily
E4O07_RS08095	COG0444	Belongs to the ABC transporter superfamily
E4O07_RS08100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O07_RS08105	COG0601	transmembrane transport
E4O07_RS08120	COG0601	transmembrane transport
E4O07_RS08125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O07_RS08130	COG0444	Belongs to the ABC transporter superfamily
E4O07_RS08135	COG4608	Belongs to the ABC transporter superfamily
E4O07_RS08145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O07_RS08145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O07_RS08185	COG0534	Mate efflux family protein
E4O07_RS08190	COG1132	(ABC) transporter
E4O07_RS08195	COG1132	(ABC) transporter
E4O07_RS08200	COG0840	transmembrane signaling receptor activity
E4O07_RS08205	COG1757	Na H antiporter
E4O07_RS08210	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O07_RS08240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O07_RS08245	COG0049	tRNA binding
E4O07_RS08250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4O07_RS08260	COG2832	Protein of unknown function (DUF454)
E4O07_RS08275	COG0756	dUTP diphosphatase activity
E4O07_RS08280	COG1185	polyribonucleotide nucleotidyltransferase activity
E4O07_RS08285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4O07_RS08290	COG0196	riboflavin kinase activity
E4O07_RS08300	COG0598	Magnesium transport protein CorA
E4O07_RS08305	COG0617	tRNA 3'-terminal CCA addition
E4O07_RS08320	COG0071	Belongs to the small heat shock protein (HSP20) family
E4O07_RS08325	COG0571	ribonuclease III activity
E4O07_RS08330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4O07_RS08335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4O07_RS08345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4O07_RS08355	COG1794	racemase activity, acting on amino acids and derivatives
E4O07_RS08360	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4O07_RS08385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4O07_RS08385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4O07_RS08400	COG1067	ATP-dependent peptidase activity
E4O07_RS08425	COG2183	response to ionizing radiation
E4O07_RS08435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4O07_RS08445	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4O07_RS08455	COG4786	Flagellar basal body rod
E4O07_RS08470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4O07_RS08475	COG2084	Dehydrogenase
E4O07_RS08480	COG2116	formate transmembrane transporter activity
E4O07_RS08505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4O07_RS08515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4O07_RS08520	COG0747	negative chemotaxis
E4O07_RS08525	COG4608	Belongs to the ABC transporter superfamily
E4O07_RS08530	COG0444	Belongs to the ABC transporter superfamily
E4O07_RS08535	COG4166	transmembrane transport
E4O07_RS08540	COG4239	(ABC) transporter, permease
E4O07_RS08545	COG0601	transmembrane transport
E4O07_RS08560	COG0017	Asparaginyl-tRNA synthetase
E4O07_RS08565	COG1686	Belongs to the peptidase S11 family
E4O07_RS08570	COG2003	Belongs to the UPF0758 family
E4O07_RS08575	COG1040	competence protein
E4O07_RS08580	COG0018	arginyl-trna synthetase
E4O07_RS08585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4O07_RS08600	COG1692	metallophosphoesterase
E4O07_RS08610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4O07_RS08625	COG2089	acid synthase
E4O07_RS08630	COG2200	EAL domain
E4O07_RS08635	COG5341	Protein conserved in bacteria
E4O07_RS08645	COG0584	glycerophosphoryl diester phosphodiesterase
E4O07_RS08650	COG1704	LemA family
E4O07_RS08660	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O07_RS08665	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O07_RS08670	COG3845	ABC transporter
E4O07_RS08675	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O07_RS08760	COG3039	Transposase
E4O07_RS08790	COG3039	Transposase
E4O07_RS08835	COG5433	transposase activity
E4O07_RS08840	COG0740	serine-type endopeptidase activity
E4O07_RS08845	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4O07_RS08855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4O07_RS08865	COG1847	R3H domain protein
E4O07_RS08870	COG0706	membrane insertase activity
E4O07_RS08875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4O07_RS08885	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4O07_RS08895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O07_RS08905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O07_RS08935	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4O07_RS08960	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O07_RS08980	COG0058	SHG alpha-glucan phosphorylase activity
E4O07_RS09010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4O07_RS09015	COG0085	RNA polymerase activity
E4O07_RS09020	COG0222	ribosome binding
E4O07_RS09025	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4O07_RS09030	COG0081	regulation of translation
E4O07_RS09035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4O07_RS09040	COG0250	Participates in transcription elongation, termination and antitermination
E4O07_RS09045	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4O07_RS09055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4O07_RS09080	COG1921	L-seryl-tRNASec selenium transferase activity
E4O07_RS09090	COG0322	excinuclease ABC activity
E4O07_RS09135	COG0326	Molecular chaperone. Has ATPase activity
E4O07_RS09140	COG0281	malic enzyme
E4O07_RS09160	COG3885	ferrous iron binding
E4O07_RS09160	COG2078	PFAM AMMECR1 domain protein
E4O07_RS09165	COG0666	response to abiotic stimulus
E4O07_RS09170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4O07_RS09205	COG1131	(ABC) transporter
E4O07_RS09220	COG1309	transcriptional regulator
E4O07_RS09225	COG1132	(ABC) transporter
E4O07_RS09225	COG2375	cellular response to nickel ion
E4O07_RS09240	COG1132	(ABC) transporter
E4O07_RS09245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O07_RS09265	COG0425	Belongs to the sulfur carrier protein TusA family
E4O07_RS09280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4O07_RS09290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4O07_RS09300	COG0549	Belongs to the carbamate kinase family
E4O07_RS09310	COG1652	LysM domain
E4O07_RS09340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4O07_RS09345	COG1363	Peptidase, m42
E4O07_RS09385	COG2890	protein-(glutamine-N5) methyltransferase activity
E4O07_RS09390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4O07_RS09420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4O07_RS09425	COG1573	uracil-dna glycosylase
E4O07_RS09435	COG0840	transmembrane signaling receptor activity
E4O07_RS09455	COG0745	RESPONSE REGULATOR receiver
E4O07_RS09475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4O07_RS09495	COG1012	belongs to the aldehyde dehydrogenase family
E4O07_RS09500	COG0357	Ribosomal RNA small subunit methyltransferase G
E4O07_RS09510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4O07_RS09535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4O07_RS09565	COG1132	(ABC) transporter
E4O07_RS09575	COG2604	Protein of unknown function DUF115
E4O07_RS09610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4O07_RS09645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4O07_RS09690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O07_RS09705	COG1132	(ABC) transporter
E4O07_RS09710	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4O07_RS09715	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4O07_RS09730	COG1132	(ABC) transporter
E4O07_RS09735	COG4988	ABC transporter
E4O07_RS09750	COG1121	(ABC) transporter
E4O07_RS09755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O07_RS09765	COG4115	mRNA cleavage
E4O07_RS09785	COG0301	tRNA thio-modification
E4O07_RS09795	COG0328	RNA-DNA hybrid ribonuclease activity
E4O07_RS09800	COG4443	Transcriptional Coactivator p15 (PC4)
E4O07_RS09805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O07_RS09810	COG0166	Belongs to the GPI family
E4O07_RS09815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4O07_RS09825	COG0564	pseudouridine synthase activity
E4O07_RS09845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4O07_RS09880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4O07_RS09895	COG1362	aminopeptidase activity
E4O07_RS09905	COG0724	RNA recognition motif
E4O07_RS09930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4O07_RS09940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4O07_RS09950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O07_RS09960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4O07_RS09975	COG1373	ATPase (AAA superfamily
E4O07_RS09985	COG3314	Sporulation integral membrane protein YlbJ
E4O07_RS09990	COG0393	Putative heavy-metal-binding
E4O07_RS09995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4O07_RS10000	COG2226	methyltransferase
E4O07_RS10005	COG0840	transmembrane signaling receptor activity
E4O07_RS10025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O07_RS10045	COG1477	protein flavinylation
E4O07_RS10050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4O07_RS10055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O07_RS10065	COG0613	PHP domain protein
E4O07_RS10070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4O07_RS10100	COG3177	Filamentation induced by cAMP protein fic
E4O07_RS10110	COG0579	oxidoreductase
E4O07_RS10115	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O07_RS10125	COG4175	Glycine betaine
E4O07_RS10125	COG0517	IMP dehydrogenase activity
E4O07_RS10140	COG3039	Transposase
E4O07_RS10170	COG1797	cobyrinic acid a,c-diamide synthase activity
E4O07_RS10175	COG0784	Response regulator, receiver
E4O07_RS10175	COG3437	response regulator, receiver
E4O07_RS10195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4O07_RS10200	COG0517	IMP dehydrogenase activity
E4O07_RS10200	COG0516	GMP reductase activity
E4O07_RS10215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4O07_RS10220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O07_RS10225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4O07_RS10255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4O07_RS10290	COG1191	sigma factor activity
E4O07_RS10305	COG1419	protein localization to endoplasmic reticulum
E4O07_RS10310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4O07_RS10315	COG0504	CTP synthase activity
E4O07_RS10330	COG1747	RNA polymerase binding
E4O07_RS10330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4O07_RS10340	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O07_RS10340	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O07_RS10340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O07_RS10340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4O07_RS10345	COG2885	chlorophyll binding
E4O07_RS10360	COG2378	regulation of single-species biofilm formation
E4O07_RS10375	COG1136	(ABC) transporter
E4O07_RS10380	COG5002	protein histidine kinase activity
E4O07_RS10385	COG0745	RESPONSE REGULATOR receiver
E4O07_RS10390	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4O07_RS10410	COG2201	protein-glutamate methylesterase activity
E4O07_RS10430	COG1137	ATPase activity
E4O07_RS10435	COG0193	aminoacyl-tRNA hydrolase activity
E4O07_RS10445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4O07_RS10455	COG0601	transmembrane transport
E4O07_RS10460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O07_RS10465	COG0444	Belongs to the ABC transporter superfamily
E4O07_RS10470	COG4608	Belongs to the ABC transporter superfamily
E4O07_RS10475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4O07_RS10480	COG1876	peptidase activity
E4O07_RS10500	COG0484	heat shock protein binding
E4O07_RS10505	COG0443	Heat shock 70 kDa protein
E4O07_RS10510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4O07_RS10515	COG3177	Filamentation induced by cAMP protein fic
E4O07_RS10525	COG1120	ATPase activity
E4O07_RS10550	COG0534	Mate efflux family protein
E4O07_RS10580	COG1132	(ABC) transporter
E4O07_RS10585	COG0488	(ABC) transporter
E4O07_RS10595	COG1192	Involved in chromosome partitioning
E4O07_RS10600	COG1475	DNA binding
E4O07_RS10620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4O07_RS10625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4O07_RS10630	COG1028	Short-chain dehydrogenase reductase Sdr
E4O07_RS10645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4O07_RS10665	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4O07_RS10670	COG0825	malonyl-CoA metabolic process
E4O07_RS10675	COG2986	histidine ammonia-lyase
E4O07_RS10690	COG0701	Predicted permease
E4O07_RS10695	COG3689	TIGRFAM TIGR03943 family protein
E4O07_RS10700	COG0714	Associated with various cellular activities
E4O07_RS10735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O07_RS10740	COG0154	amidase activity
E4O07_RS10745	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O07_RS10985	COG4555	ABC transporter
E4O07_RS11025	COG1151	hydroxylamine reductase activity
E4O07_RS11040	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4O07_RS11045	COG0577	efflux transmembrane transporter activity
E4O07_RS11045	COG1136	(ABC) transporter
E4O07_RS11090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4O07_RS11125	COG0813	purine-nucleoside phosphorylase activity
E4O07_RS11130	COG4536	flavin adenine dinucleotide binding
E4O07_RS11135	COG0840	transmembrane signaling receptor activity
E4O07_RS11150	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4O07_RS11155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O07_RS11175	COG2235	arginine
E4O07_RS11180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O07_RS11190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4O07_RS11205	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4O07_RS11250	COG0515	serine threonine protein kinase
E4O07_RS11265	COG0343	queuine tRNA-ribosyltransferase activity
E4O07_RS11275	COG1381	Involved in DNA repair and RecF pathway recombination
E4O07_RS11280	COG0514	ATP-dependent DNA helicase (RecQ)
E4O07_RS11285	COG1592	Rubrerythrin
E4O07_RS11290	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4O07_RS11295	COG0501	Belongs to the peptidase M48B family
E4O07_RS11305	COG0543	2 iron, 2 sulfur cluster binding
E4O07_RS11340	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4O07_RS11360	COG1924	4 iron, 4 sulfur cluster binding
E4O07_RS11370	COG1653	transport
E4O07_RS11375	COG0395	ABC-type sugar transport system, permease component
E4O07_RS11385	COG3842	ATPase activity
E4O07_RS11395	COG0523	cobalamin synthesis protein
E4O07_RS11400	COG1840	ABC-type Fe3 transport system, periplasmic component
E4O07_RS11405	COG4133	protoheme IX ABC transporter activity
E4O07_RS11415	COG3842	ATPase activity
E4O07_RS11435	COG1132	(ABC) transporter
E4O07_RS11440	COG3271	cysteine-type peptidase activity
E4O07_RS11440	COG2274	protein secretion by the type I secretion system
E4O07_RS11455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4O07_RS11465	COG0728	peptidoglycan biosynthetic process
E4O07_RS11470	COG0786	glutamate:sodium symporter activity
E4O07_RS11485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O07_RS11490	COG3588	fructose-bisphosphate aldolase
E4O07_RS11495	COG1487	ribonuclease activity
E4O07_RS11505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O07_RS11510	COG1132	(ABC) transporter
E4O07_RS11525	COG5433	transposase activity
E4O07_RS11540	COG1136	(ABC) transporter
E4O07_RS11570	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4O07_RS11580	COG0569	domain protein
E4O07_RS11585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4O07_RS11610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4O07_RS11620	COG3706	GGDEF domain
E4O07_RS11640	COG0012	GTP binding
E4O07_RS11645	COG0616	signal peptide processing
E4O07_RS11705	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4O07_RS11710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O07_RS11715	COG0569	domain protein
E4O07_RS11725	COG0714	Associated with various cellular activities
E4O07_RS11730	COG4536	flavin adenine dinucleotide binding
E4O07_RS11735	COG4536	flavin adenine dinucleotide binding
E4O07_RS11760	COG0514	ATP-dependent DNA helicase (RecQ)
E4O07_RS11770	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
E4O07_RS11780	COG1518	maintenance of DNA repeat elements
E4O07_RS11785	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4O07_RS11795	COG1309	transcriptional regulator
E4O07_RS11800	COG0534	Mate efflux family protein
E4O07_RS11820	COG1595	DNA-templated transcription, initiation
E4O07_RS11825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O07_RS11830	COG0628	permease
E4O07_RS11835	COG0363	glucosamine-6-phosphate deaminase activity
E4O07_RS11840	COG2855	membrane
E4O07_RS11845	COG0840	transmembrane signaling receptor activity
E4O07_RS11855	COG0733	neurotransmitter:sodium symporter activity
E4O07_RS11870	COG4221	oxidoreductase activity
E4O07_RS11875	COG0789	Transcriptional regulator
E4O07_RS11905	COG1132	(ABC) transporter
E4O07_RS11910	COG1132	(ABC) transporter
E4O07_RS11970	COG3842	ATPase activity
E4O07_RS11975	COG3833	ABC-type maltose transport systems, permease component
E4O07_RS11980	COG1175	transmembrane transport
E4O07_RS11995	COG1418	mRNA catabolic process
E4O07_RS12010	COG3177	Filamentation induced by cAMP protein fic
E4O07_RS12015	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4O07_RS12020	COG0592	DNA-directed DNA polymerase activity
E4O07_RS12025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4O07_RS12075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O07_RS12140	COG4608	Belongs to the ABC transporter superfamily
E4O07_RS12145	COG0444	Belongs to the ABC transporter superfamily
E4O07_RS12150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O07_RS12160	COG4166	transmembrane transport
E4O07_RS12185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4O07_RS12190	COG1929	Belongs to the glycerate kinase type-1 family
E4O07_RS12195	COG2610	gluconate transmembrane transporter activity
E4O07_RS12210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4O07_RS12225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4O07_RS12235	COG1132	(ABC) transporter
E4O07_RS12275	COG2184	nucleotidyltransferase activity
E4O07_RS12285	COG0730	response to heat
E4O07_RS12300	COG0840	transmembrane signaling receptor activity
E4O07_RS12310	COG4208	sulfate ABC transporter
E4O07_RS12315	COG3839	Belongs to the ABC transporter superfamily
E4O07_RS12335	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4O07_RS12370	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4O07_RS12375	COG1674	ftsk spoiiie
E4O07_RS12380	COG1968	undecaprenyl-diphosphatase activity
E4O07_RS12385	COG0419	ATPase involved in DNA repair
E4O07_RS12390	COG0420	3'-5' exonuclease activity
E4O07_RS12395	COG3290	protein histidine kinase activity
E4O07_RS12395	COG0840	transmembrane signaling receptor activity
E4O07_RS12405	COG1131	(ABC) transporter
E4O07_RS12425	COG0716	FMN binding
E4O07_RS12440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4O07_RS12490	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O07_RS12515	COG4585	Histidine kinase
E4O07_RS12520	COG1473	amidohydrolase
E4O07_RS12620	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O07_RS12650	COG2375	cellular response to nickel ion
E4O07_RS12650	COG1132	(ABC) transporter
E4O07_RS12655	COG1132	(ABC) transporter
E4O07_RS12660	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4O07_RS12660	COG0540	Belongs to the ATCase OTCase family
E4O07_RS12665	COG5002	protein histidine kinase activity
E4O07_RS12665	COG5001	Diguanylate cyclase
E4O07_RS12695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4O07_RS12725	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4O07_RS12740	COG1774	PSP1 C-terminal conserved region
E4O07_RS12745	COG1728	Protein conserved in bacteria
E4O07_RS12755	COG0739	heme binding
E4O07_RS12765	COG0366	Alpha amylase catalytic
E4O07_RS12775	COG1609	Transcriptional regulator
E4O07_RS12780	COG1129	ABC transporter
E4O07_RS12805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4O07_RS12810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4O07_RS12830	COG1506	peptidase
E4O07_RS12830	COG4946	Tricorn protease homolog
E4O07_RS12830	COG0823	Involved in the tonB-independent uptake of proteins
E4O07_RS12840	COG3177	Filamentation induced by cAMP protein fic
E4O07_RS12860	COG1373	ATPase (AAA superfamily
E4O07_RS12870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4O07_RS12875	COG0215	cysteine-tRNA ligase activity
E4O07_RS12890	COG1305	Transglutaminase-like
E4O07_RS12895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O07_RS12900	COG0569	domain protein
E4O07_RS12905	COG2887	Belongs to the helicase family. UvrD subfamily
E4O07_RS12910	COG1074	ATP-dependent DNA helicase activity
E4O07_RS12915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O07_RS12935	COG0840	transmembrane signaling receptor activity
E4O07_RS12940	COG0826	peptidase U32
E4O07_RS12955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O07_RS12960	COG1509	lysine 2,3-aminomutase activity
E4O07_RS12965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O07_RS12970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O07_RS12985	COG0205	6-phosphofructokinase activity
E4O07_RS13010	COG1373	ATPase (AAA superfamily
E4O07_RS13025	COG0346	lactoylglutathione lyase activity
E4O07_RS13060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O07_RS13070	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O07_RS13075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O07_RS13080	COG1684	flagellar biosynthetic protein fliR
E4O07_RS13085	COG1987	bacterial-type flagellum assembly
E4O07_RS13130	COG1228	amidohydrolase
E4O07_RS13150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4O07_RS13155	COG2217	Heavy metal translocating P-type atpase
E4O07_RS13165	COG0494	nUDIX hydrolase
E4O07_RS13170	COG0783	Belongs to the Dps family
E4O07_RS13175	COG0450	alkyl hydroperoxide reductase
E4O07_RS13180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4O07_RS13200	COG1363	Peptidase, m42
E4O07_RS13210	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4O07_RS13215	COG0423	glycine-tRNA ligase activity
E4O07_RS13235	COG1472	Belongs to the glycosyl hydrolase 3 family
E4O07_RS13275	COG0537	adenosine 5'-monophosphoramidase activity
E4O07_RS13330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4O07_RS13340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4O07_RS13350	COG0280	phosphate acetyltransferase
E4O07_RS13355	COG0457	Tetratricopeptide repeat
E4O07_RS13360	COG1393	Belongs to the ArsC family
E4O07_RS13365	COG0488	(ABC) transporter
E4O07_RS13370	COG1132	(ABC) transporter
E4O07_RS13375	COG1132	(ABC) transporter
E4O07_RS13395	COG0187	DNA topoisomerase II activity