locus-tag	class	description
E4O04_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4O04_RS00010	COG0187	DNA topoisomerase II activity
E4O04_RS00030	COG1132	(ABC) transporter
E4O04_RS00035	COG1132	(ABC) transporter
E4O04_RS00045	COG0423	glycine-tRNA ligase activity
E4O04_RS00065	COG1472	Belongs to the glycosyl hydrolase 3 family
E4O04_RS00105	COG0537	adenosine 5'-monophosphoramidase activity
E4O04_RS00115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4O04_RS00120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4O04_RS00130	COG0280	phosphate acetyltransferase
E4O04_RS00135	COG0457	Tetratricopeptide repeat
E4O04_RS00140	COG1393	Belongs to the ArsC family
E4O04_RS00145	COG0488	(ABC) transporter
E4O04_RS00155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4O04_RS00165	COG1363	Peptidase, m42
E4O04_RS00185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4O04_RS00190	COG0450	alkyl hydroperoxide reductase
E4O04_RS00195	COG0783	Belongs to the Dps family
E4O04_RS00200	COG0494	nUDIX hydrolase
E4O04_RS00210	COG2217	Heavy metal translocating P-type atpase
E4O04_RS00215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4O04_RS00235	COG1228	amidohydrolase
E4O04_RS00275	COG1987	bacterial-type flagellum assembly
E4O04_RS00280	COG1684	flagellar biosynthetic protein fliR
E4O04_RS00285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O04_RS00290	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O04_RS00300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O04_RS00335	COG0346	lactoylglutathione lyase activity
E4O04_RS00355	COG1373	ATPase (AAA superfamily
E4O04_RS00380	COG0205	6-phosphofructokinase activity
E4O04_RS00395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O04_RS00400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O04_RS00405	COG1509	lysine 2,3-aminomutase activity
E4O04_RS00410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O04_RS00415	COG0826	peptidase U32
E4O04_RS00420	COG0840	transmembrane signaling receptor activity
E4O04_RS00425	COG0196	riboflavin kinase activity
E4O04_RS00430	COG1113	amino acid transport
E4O04_RS00435	COG1063	alcohol dehydrogenase
E4O04_RS00440	COG1830	Aldolase
E4O04_RS00460	COG1012	belongs to the aldehyde dehydrogenase family
E4O04_RS00480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O04_RS00485	COG1074	ATP-dependent DNA helicase activity
E4O04_RS00490	COG2887	Belongs to the helicase family. UvrD subfamily
E4O04_RS00495	COG0569	domain protein
E4O04_RS00500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O04_RS00505	COG1305	Transglutaminase-like
E4O04_RS00520	COG0215	cysteine-tRNA ligase activity
E4O04_RS00525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4O04_RS00535	COG1373	ATPase (AAA superfamily
E4O04_RS00555	COG3177	Filamentation induced by cAMP protein fic
E4O04_RS00565	COG0823	Involved in the tonB-independent uptake of proteins
E4O04_RS00565	COG1506	peptidase
E4O04_RS00565	COG4946	Tricorn protease homolog
E4O04_RS00605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E4O04_RS00610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4O04_RS00635	COG1129	ABC transporter
E4O04_RS00640	COG1609	Transcriptional regulator
E4O04_RS00650	COG0366	Alpha amylase catalytic
E4O04_RS00660	COG0739	heme binding
E4O04_RS00670	COG1728	Protein conserved in bacteria
E4O04_RS00675	COG1774	PSP1 C-terminal conserved region
E4O04_RS00690	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4O04_RS00750	COG5002	protein histidine kinase activity
E4O04_RS00750	COG5001	Diguanylate cyclase
E4O04_RS00755	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
E4O04_RS00755	COG0540	Belongs to the ATCase OTCase family
E4O04_RS00760	COG1132	(ABC) transporter
E4O04_RS00765	COG1132	(ABC) transporter
E4O04_RS00765	COG2375	cellular response to nickel ion
E4O04_RS00785	COG2186	Transcriptional regulator
E4O04_RS00805	COG1070	Carbohydrate kinase
E4O04_RS00835	COG4143	(ABC) transporter
E4O04_RS00840	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4O04_RS00845	COG3842	ATPase activity
E4O04_RS00860	COG1473	amidohydrolase
E4O04_RS00865	COG4585	Histidine kinase
E4O04_RS00940	COG0716	FMN binding
E4O04_RS00960	COG1131	(ABC) transporter
E4O04_RS00970	COG3290	protein histidine kinase activity
E4O04_RS00970	COG0840	transmembrane signaling receptor activity
E4O04_RS00980	COG0419	ATPase involved in DNA repair
E4O04_RS00985	COG1968	undecaprenyl-diphosphatase activity
E4O04_RS00990	COG1674	ftsk spoiiie
E4O04_RS00995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4O04_RS01035	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4O04_RS01055	COG3839	Belongs to the ABC transporter superfamily
E4O04_RS01060	COG4208	sulfate ABC transporter
E4O04_RS01070	COG0840	transmembrane signaling receptor activity
E4O04_RS01085	COG0730	response to heat
E4O04_RS01095	COG2184	nucleotidyltransferase activity
E4O04_RS01135	COG1132	(ABC) transporter
E4O04_RS01145	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4O04_RS01160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4O04_RS01175	COG2610	gluconate transmembrane transporter activity
E4O04_RS01180	COG1929	Belongs to the glycerate kinase type-1 family
E4O04_RS01185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4O04_RS01210	COG4166	transmembrane transport
E4O04_RS01220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O04_RS01225	COG0444	Belongs to the ABC transporter superfamily
E4O04_RS01230	COG4608	Belongs to the ABC transporter superfamily
E4O04_RS01295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O04_RS01325	COG1487	ribonuclease activity
E4O04_RS01360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4O04_RS01365	COG0592	DNA-directed DNA polymerase activity
E4O04_RS01370	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4O04_RS01375	COG3177	Filamentation induced by cAMP protein fic
E4O04_RS01390	COG1418	mRNA catabolic process
E4O04_RS01400	COG1175	transmembrane transport
E4O04_RS01405	COG3833	ABC-type maltose transport systems, permease component
E4O04_RS01410	COG3842	ATPase activity
E4O04_RS01475	COG1132	(ABC) transporter
E4O04_RS01480	COG1132	(ABC) transporter
E4O04_RS01495	COG3586	endonuclease activity
E4O04_RS01505	COG0789	Transcriptional regulator
E4O04_RS01510	COG4221	oxidoreductase activity
E4O04_RS01525	COG0733	neurotransmitter:sodium symporter activity
E4O04_RS01535	COG0840	transmembrane signaling receptor activity
E4O04_RS01540	COG2855	membrane
E4O04_RS01545	COG0363	glucosamine-6-phosphate deaminase activity
E4O04_RS01550	COG0628	permease
E4O04_RS01555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O04_RS01560	COG1595	DNA-templated transcription, initiation
E4O04_RS01580	COG0534	Mate efflux family protein
E4O04_RS01585	COG1309	transcriptional regulator
E4O04_RS01595	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E4O04_RS01600	COG1518	maintenance of DNA repeat elements
E4O04_RS01610	COG0514	ATP-dependent DNA helicase (RecQ)
E4O04_RS01635	COG4536	flavin adenine dinucleotide binding
E4O04_RS01640	COG4536	flavin adenine dinucleotide binding
E4O04_RS01645	COG0714	Associated with various cellular activities
E4O04_RS01655	COG0569	domain protein
E4O04_RS01660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4O04_RS01665	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4O04_RS01725	COG0616	signal peptide processing
E4O04_RS01730	COG0012	GTP binding
E4O04_RS01765	COG3706	GGDEF domain
E4O04_RS01780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E4O04_RS01805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4O04_RS01810	COG0569	domain protein
E4O04_RS01820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4O04_RS01845	COG1136	(ABC) transporter
E4O04_RS01870	COG1132	(ABC) transporter
E4O04_RS01875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O04_RS01890	COG1487	ribonuclease activity
E4O04_RS01895	COG3588	fructose-bisphosphate aldolase
E4O04_RS01900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4O04_RS01905	COG0840	transmembrane signaling receptor activity
E4O04_RS01915	COG0786	glutamate:sodium symporter activity
E4O04_RS01920	COG0728	peptidoglycan biosynthetic process
E4O04_RS01935	COG1132	(ABC) transporter
E4O04_RS01945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4O04_RS01960	COG2274	protein secretion by the type I secretion system
E4O04_RS01960	COG3271	cysteine-type peptidase activity
E4O04_RS01965	COG1132	(ABC) transporter
E4O04_RS01980	COG4133	protoheme IX ABC transporter activity
E4O04_RS02000	COG0523	cobalamin synthesis protein
E4O04_RS02010	COG3842	ATPase activity
E4O04_RS02020	COG0395	ABC-type sugar transport system, permease component
E4O04_RS02025	COG1653	transport
E4O04_RS02035	COG1924	4 iron, 4 sulfur cluster binding
E4O04_RS02045	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4O04_RS02065	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4O04_RS02075	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4O04_RS02115	COG0543	2 iron, 2 sulfur cluster binding
E4O04_RS02125	COG0501	Belongs to the peptidase M48B family
E4O04_RS02130	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4O04_RS02200	COG1592	Rubrerythrin
E4O04_RS02205	COG0514	ATP-dependent DNA helicase (RecQ)
E4O04_RS02210	COG1381	Involved in DNA repair and RecF pathway recombination
E4O04_RS02220	COG0343	queuine tRNA-ribosyltransferase activity
E4O04_RS02235	COG0515	serine threonine protein kinase
E4O04_RS02280	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4O04_RS02300	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4O04_RS02310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4O04_RS02315	COG2235	arginine
E4O04_RS02335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O04_RS02340	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E4O04_RS02355	COG0840	transmembrane signaling receptor activity
E4O04_RS02360	COG4536	flavin adenine dinucleotide binding
E4O04_RS02365	COG0813	purine-nucleoside phosphorylase activity
E4O04_RS02390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4O04_RS02440	COG0577	efflux transmembrane transporter activity
E4O04_RS02440	COG1136	(ABC) transporter
E4O04_RS02445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E4O04_RS02470	COG0840	transmembrane signaling receptor activity
E4O04_RS02485	COG4555	ABC transporter
E4O04_RS02590	COG3039	Transposase
E4O04_RS02610	COG1132	(ABC) transporter
E4O04_RS02615	COG1129	ABC transporter
E4O04_RS02630	COG1309	transcriptional regulator
E4O04_RS02780	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O04_RS02785	COG0154	amidase activity
E4O04_RS02790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4O04_RS02825	COG0714	Associated with various cellular activities
E4O04_RS02830	COG3689	TIGRFAM TIGR03943 family protein
E4O04_RS02835	COG0701	Predicted permease
E4O04_RS02850	COG2986	histidine ammonia-lyase
E4O04_RS02855	COG0825	malonyl-CoA metabolic process
E4O04_RS02860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4O04_RS02885	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4O04_RS02900	COG1028	Short-chain dehydrogenase reductase Sdr
E4O04_RS02905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4O04_RS02910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4O04_RS02930	COG1475	DNA binding
E4O04_RS02935	COG1192	Involved in chromosome partitioning
E4O04_RS02945	COG0488	(ABC) transporter
E4O04_RS02950	COG1132	(ABC) transporter
E4O04_RS02980	COG0534	Mate efflux family protein
E4O04_RS03005	COG1120	ATPase activity
E4O04_RS03015	COG3177	Filamentation induced by cAMP protein fic
E4O04_RS03020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4O04_RS03025	COG0443	Heat shock 70 kDa protein
E4O04_RS03030	COG0484	heat shock protein binding
E4O04_RS03050	COG1876	peptidase activity
E4O04_RS03055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4O04_RS03060	COG4608	Belongs to the ABC transporter superfamily
E4O04_RS03065	COG0444	Belongs to the ABC transporter superfamily
E4O04_RS03070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O04_RS03075	COG0601	transmembrane transport
E4O04_RS03085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4O04_RS03095	COG0193	aminoacyl-tRNA hydrolase activity
E4O04_RS03100	COG1137	ATPase activity
E4O04_RS03120	COG2201	protein-glutamate methylesterase activity
E4O04_RS03140	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4O04_RS03145	COG0745	RESPONSE REGULATOR receiver
E4O04_RS03150	COG0642	Histidine kinase
E4O04_RS03155	COG1136	(ABC) transporter
E4O04_RS03170	COG2378	regulation of single-species biofilm formation
E4O04_RS03185	COG2885	chlorophyll binding
E4O04_RS03215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4O04_RS03240	COG3451	type IV secretory pathway VirB4
E4O04_RS03265	COG2948	multi-organism process
E4O04_RS03315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4O04_RS03330	COG2003	Belongs to the UPF0758 family
E4O04_RS03375	COG0629	single-stranded DNA binding
E4O04_RS03430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4O04_RS03430	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O04_RS03430	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O04_RS03430	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O04_RS03440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4O04_RS03440	COG1747	RNA polymerase binding
E4O04_RS03455	COG0504	CTP synthase activity
E4O04_RS03460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4O04_RS03465	COG1419	protein localization to endoplasmic reticulum
E4O04_RS03480	COG1191	sigma factor activity
E4O04_RS03510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4O04_RS03540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4O04_RS03545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O04_RS03550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4O04_RS03565	COG0516	GMP reductase activity
E4O04_RS03565	COG0517	IMP dehydrogenase activity
E4O04_RS03570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4O04_RS03590	COG0784	Response regulator, receiver
E4O04_RS03590	COG3437	response regulator, receiver
E4O04_RS03595	COG1797	cobyrinic acid a,c-diamide synthase activity
E4O04_RS03630	COG0517	IMP dehydrogenase activity
E4O04_RS03630	COG4175	Glycine betaine
E4O04_RS03640	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4O04_RS03645	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E4O04_RS03645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4O04_RS03655	COG3177	Filamentation induced by cAMP protein fic
E4O04_RS03665	COG1164	Oligoendopeptidase f
E4O04_RS03685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4O04_RS03690	COG0613	PHP domain protein
E4O04_RS03700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4O04_RS03705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4O04_RS03710	COG1477	protein flavinylation
E4O04_RS03730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O04_RS03745	COG0840	transmembrane signaling receptor activity
E4O04_RS03750	COG0840	transmembrane signaling receptor activity
E4O04_RS03760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4O04_RS03765	COG0393	Putative heavy-metal-binding
E4O04_RS03770	COG3314	Sporulation integral membrane protein YlbJ
E4O04_RS03775	COG2264	protein methyltransferase activity
E4O04_RS03780	COG1373	ATPase (AAA superfamily
E4O04_RS03795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4O04_RS03805	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O04_RS03815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4O04_RS03825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4O04_RS03850	COG0724	RNA recognition motif
E4O04_RS03860	COG1362	aminopeptidase activity
E4O04_RS03875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4O04_RS03910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4O04_RS03930	COG0564	pseudouridine synthase activity
E4O04_RS03940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4O04_RS03945	COG0166	Belongs to the GPI family
E4O04_RS03955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4O04_RS03960	COG4443	Transcriptional Coactivator p15 (PC4)
E4O04_RS03965	COG0328	RNA-DNA hybrid ribonuclease activity
E4O04_RS03970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4O04_RS03975	COG0301	tRNA thio-modification
E4O04_RS03995	COG4115	mRNA cleavage
E4O04_RS04005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O04_RS04010	COG1121	(ABC) transporter
E4O04_RS04025	COG4988	ABC transporter
E4O04_RS04030	COG1132	(ABC) transporter
E4O04_RS04045	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4O04_RS04050	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4O04_RS04065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O04_RS04110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4O04_RS04165	COG2604	Protein of unknown function DUF115
E4O04_RS04175	COG1132	(ABC) transporter
E4O04_RS04200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4O04_RS04235	COG0357	Ribosomal RNA small subunit methyltransferase G
E4O04_RS04240	COG1012	belongs to the aldehyde dehydrogenase family
E4O04_RS04260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4O04_RS04280	COG0745	RESPONSE REGULATOR receiver
E4O04_RS04300	COG0840	transmembrane signaling receptor activity
E4O04_RS04310	COG1573	uracil-dna glycosylase
E4O04_RS04315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4O04_RS04350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4O04_RS04355	COG2890	protein-(glutamine-N5) methyltransferase activity
E4O04_RS04395	COG1363	Peptidase, m42
E4O04_RS04400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4O04_RS04430	COG1652	LysM domain
E4O04_RS04440	COG0549	Belongs to the carbamate kinase family
E4O04_RS04450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4O04_RS04460	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4O04_RS04480	COG0425	Belongs to the sulfur carrier protein TusA family
E4O04_RS04500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O04_RS04505	COG1132	(ABC) transporter
E4O04_RS04510	COG2375	cellular response to nickel ion
E4O04_RS04510	COG1132	(ABC) transporter
E4O04_RS04515	COG1309	transcriptional regulator
E4O04_RS04530	COG1131	(ABC) transporter
E4O04_RS04560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4O04_RS04565	COG0666	response to abiotic stimulus
E4O04_RS04570	COG2078	PFAM AMMECR1 domain protein
E4O04_RS04570	COG3885	ferrous iron binding
E4O04_RS04590	COG0281	malic enzyme
E4O04_RS04595	COG0326	Molecular chaperone. Has ATPase activity
E4O04_RS04645	COG0322	excinuclease ABC activity
E4O04_RS04655	COG1921	L-seryl-tRNASec selenium transferase activity
E4O04_RS04680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4O04_RS04690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4O04_RS04695	COG0250	Participates in transcription elongation, termination and antitermination
E4O04_RS04700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4O04_RS04705	COG0081	regulation of translation
E4O04_RS04710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4O04_RS04715	COG0222	ribosome binding
E4O04_RS04720	COG0085	RNA polymerase activity
E4O04_RS04725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4O04_RS04755	COG0058	SHG alpha-glucan phosphorylase activity
E4O04_RS04775	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O04_RS04800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4O04_RS04830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O04_RS04840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O04_RS04850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4O04_RS04860	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4O04_RS04865	COG0706	membrane insertase activity
E4O04_RS04870	COG1847	R3H domain protein
E4O04_RS04880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4O04_RS04890	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4O04_RS04895	COG0740	serine-type endopeptidase activity
E4O04_RS04900	COG5433	transposase activity
E4O04_RS04910	COG0148	phosphopyruvate hydratase activity
E4O04_RS04975	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O04_RS04980	COG3845	ABC transporter
E4O04_RS04985	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O04_RS04990	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O04_RS05000	COG1704	LemA family
E4O04_RS05005	COG0584	glycerophosphoryl diester phosphodiesterase
E4O04_RS05015	COG5341	Protein conserved in bacteria
E4O04_RS05020	COG2200	EAL domain
E4O04_RS05025	COG2089	acid synthase
E4O04_RS05040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4O04_RS05050	COG1692	metallophosphoesterase
E4O04_RS05065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4O04_RS05070	COG0018	arginyl-trna synthetase
E4O04_RS05075	COG1040	competence protein
E4O04_RS05080	COG2003	Belongs to the UPF0758 family
E4O04_RS05085	COG1686	Belongs to the peptidase S11 family
E4O04_RS05090	COG0017	Asparaginyl-tRNA synthetase
E4O04_RS05110	COG4239	(ABC) transporter, permease
E4O04_RS05115	COG4166	transmembrane transport
E4O04_RS05120	COG0444	Belongs to the ABC transporter superfamily
E4O04_RS05125	COG4608	Belongs to the ABC transporter superfamily
E4O04_RS05130	COG0747	negative chemotaxis
E4O04_RS05145	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4O04_RS05155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4O04_RS05180	COG2116	formate transmembrane transporter activity
E4O04_RS05185	COG2084	Dehydrogenase
E4O04_RS05190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4O04_RS05205	COG4786	Flagellar basal body rod
E4O04_RS05215	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4O04_RS05225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4O04_RS05235	COG2183	response to ionizing radiation
E4O04_RS05260	COG1067	ATP-dependent peptidase activity
E4O04_RS05275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4O04_RS05275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E4O04_RS05300	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4O04_RS05305	COG1794	racemase activity, acting on amino acids and derivatives
E4O04_RS05315	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E4O04_RS05325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4O04_RS05330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4O04_RS05335	COG0571	ribonuclease III activity
E4O04_RS05340	COG0071	Belongs to the small heat shock protein (HSP20) family
E4O04_RS05355	COG0617	tRNA 3'-terminal CCA addition
E4O04_RS05360	COG0598	Magnesium transport protein CorA
E4O04_RS05370	COG0196	riboflavin kinase activity
E4O04_RS05375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4O04_RS05380	COG1185	polyribonucleotide nucleotidyltransferase activity
E4O04_RS05385	COG0756	dUTP diphosphatase activity
E4O04_RS05400	COG2832	Protein of unknown function (DUF454)
E4O04_RS05405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4O04_RS05410	COG0049	tRNA binding
E4O04_RS05415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O04_RS05445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O04_RS05450	COG1757	Na H antiporter
E4O04_RS05455	COG0840	transmembrane signaling receptor activity
E4O04_RS05460	COG1132	(ABC) transporter
E4O04_RS05465	COG1132	(ABC) transporter
E4O04_RS05470	COG0534	Mate efflux family protein
E4O04_RS05505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O04_RS05505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4O04_RS05515	COG4608	Belongs to the ABC transporter superfamily
E4O04_RS05520	COG0444	Belongs to the ABC transporter superfamily
E4O04_RS05525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O04_RS05530	COG0601	transmembrane transport
E4O04_RS05545	COG0601	transmembrane transport
E4O04_RS05550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O04_RS05555	COG0444	Belongs to the ABC transporter superfamily
E4O04_RS05560	COG4608	Belongs to the ABC transporter superfamily
E4O04_RS05565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4O04_RS05565	COG0426	domain, Protein
E4O04_RS05570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O04_RS05575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4O04_RS05595	COG0285	dihydrofolate synthase activity
E4O04_RS05605	COG1561	YicC-like family, N-terminal region
E4O04_RS05610	COG1102	Psort location Cytoplasmic, score
E4O04_RS05615	COG3706	GGDEF domain
E4O04_RS05625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O04_RS05640	COG3330	Domain of unknown function (DUF4912)
E4O04_RS05650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4O04_RS05655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4O04_RS05685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4O04_RS05690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4O04_RS05695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4O04_RS05705	COG0779	Required for maturation of 30S ribosomal subunits
E4O04_RS05725	COG0563	adenylate kinase activity
E4O04_RS05735	COG2801	Transposase and inactivated derivatives
E4O04_RS05755	COG1136	(ABC) transporter
E4O04_RS05760	COG1136	(ABC) transporter
E4O04_RS05760	COG0577	efflux transmembrane transporter activity
E4O04_RS05765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4O04_RS05780	COG1639	'signal transduction protein
E4O04_RS05785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4O04_RS05795	COG0101	tRNA pseudouridine synthase activity
E4O04_RS05810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4O04_RS05815	COG1132	(ABC) transporter
E4O04_RS05825	COG0826	peptidase U32
E4O04_RS05850	COG3033	Beta-eliminating lyase
E4O04_RS05870	COG1366	Belongs to the anti-sigma-factor antagonist family
E4O04_RS05910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4O04_RS05915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4O04_RS06055	COG1475	DNA binding
E4O04_RS06105	COG4974	Belongs to the 'phage' integrase family
E4O04_RS06120	COG0459	protein refolding
E4O04_RS06145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4O04_RS06155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4O04_RS06185	COG2801	Transposase and inactivated derivatives
E4O04_RS06195	COG1505	serine-type exopeptidase activity
E4O04_RS06200	COG2001	Belongs to the MraZ family
E4O04_RS06205	COG0275	rRNA processing
E4O04_RS06215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4O04_RS06220	COG0772	Belongs to the SEDS family
E4O04_RS06235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4O04_RS06240	COG4974	Belongs to the 'phage' integrase family
E4O04_RS06250	COG0758	DNA mediated transformation
E4O04_RS06255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4O04_RS06255	COG0551	DNA topoisomerase type I activity
E4O04_RS06260	COG4974	Belongs to the 'phage' integrase family
E4O04_RS06265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4O04_RS06270	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4O04_RS06285	COG1677	Flagellar hook-basal body complex protein FliE
E4O04_RS06290	COG1766	The M ring may be actively involved in energy transduction
E4O04_RS06300	COG1317	bacterial-type flagellum organization
E4O04_RS06305	COG1157	protein secretion by the type III secretion system
E4O04_RS06330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O04_RS06335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4O04_RS06340	COG1121	(ABC) transporter
E4O04_RS06345	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O04_RS06365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4O04_RS06390	COG0149	triose-phosphate isomerase activity
E4O04_RS06405	COG1702	phosphate starvation-inducible protein PhoH
E4O04_RS06410	COG1480	7TM receptor with intracellular HD hydrolase
E4O04_RS06415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4O04_RS06465	COG1193	negative regulation of DNA recombination
E4O04_RS06485	COG1115	amino acid carrier protein
E4O04_RS06490	COG4750	Nucleotidyl transferase
E4O04_RS06505	COG3118	belongs to the thioredoxin family
E4O04_RS06510	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4O04_RS06565	COG4475	Protein of unknown function (DUF436)
E4O04_RS06585	COG3621	Patatin-like phospholipase
E4O04_RS06605	COG0714	Associated with various cellular activities
E4O04_RS06615	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4O04_RS06635	COG0840	transmembrane signaling receptor activity
E4O04_RS06655	COG1122	ATPase activity
E4O04_RS06675	COG0312	modulator of DNA gyrase
E4O04_RS06680	COG0312	modulator of DNA gyrase
E4O04_RS06685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4O04_RS06690	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4O04_RS06695	COG5433	transposase activity
E4O04_RS06705	COG1388	LysM domain
E4O04_RS06705	COG0791	NLP P60 protein
E4O04_RS06725	COG0497	DNA recombination
E4O04_RS06740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4O04_RS06745	COG0312	modulator of DNA gyrase
E4O04_RS06760	COG0433	COG0433 Predicted ATPase
E4O04_RS06770	COG0768	penicillin binding
E4O04_RS06775	COG2604	Protein of unknown function DUF115
E4O04_RS06800	COG1739	Uncharacterized protein family UPF0029
E4O04_RS06825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4O04_RS06835	COG0330	HflC and HflK could
E4O04_RS06840	COG0330	HflC and HflK could
E4O04_RS06860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4O04_RS06865	COG2088	sporulation resulting in formation of a cellular spore
E4O04_RS06875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4O04_RS06880	COG0037	tRNA processing
E4O04_RS06885	COG0457	Tetratricopeptide repeat
E4O04_RS06890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O04_RS06910	COG0358	DNA primase activity
E4O04_RS06915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O04_RS06935	COG1077	Cell shape determining protein MreB Mrl
E4O04_RS06950	COG0768	penicillin binding
E4O04_RS06955	COG0772	Belongs to the SEDS family
E4O04_RS06970	COG2017	converts alpha-aldose to the beta-anomer
E4O04_RS06980	COG2252	PERMEase
E4O04_RS06985	COG0525	valine-tRNA ligase activity
E4O04_RS07020	COG2378	regulation of single-species biofilm formation
E4O04_RS07065	COG0535	radical SAM domain protein
E4O04_RS07070	COG1132	(ABC) transporter
E4O04_RS07080	COG4555	ABC transporter
E4O04_RS07090	COG2207	Transcriptional regulator
E4O04_RS07125	COG1136	(ABC) transporter
E4O04_RS07130	COG0556	nucleotide-excision repair
E4O04_RS07135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4O04_RS07135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4O04_RS07140	COG0557	exoribonuclease II activity
E4O04_RS07160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4O04_RS07175	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4O04_RS07180	COG0640	Transcriptional regulator
E4O04_RS07185	COG2217	Heavy metal translocating P-type atpase
E4O04_RS07200	COG0564	pseudouridine synthase activity
E4O04_RS07215	COG4656	Part of a membrane complex involved in electron transport
E4O04_RS07220	COG4658	electron transport chain
E4O04_RS07255	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4O04_RS07260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4O04_RS07260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4O04_RS07270	COG0488	(ABC) transporter
E4O04_RS07280	COG0047	phosphoribosylformylglycinamidine synthase activity
E4O04_RS07290	COG1078	dGTPase activity
E4O04_RS07315	COG0475	glutathione-regulated potassium exporter activity
E4O04_RS07335	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4O04_RS07335	COG0028	Belongs to the TPP enzyme family
E4O04_RS07345	COG1373	ATPase (AAA superfamily
E4O04_RS07370	COG2423	ornithine cyclodeaminase activity
E4O04_RS07380	COG1216	Glycosyl transferase, family 2
E4O04_RS07420	COG1216	Glycosyl transferase, family 2
E4O04_RS07420	COG1442	glycosyl transferase family 8
E4O04_RS07425	COG3306	glycosyltransferase involved in LPS biosynthesis
E4O04_RS07435	COG0463	Glycosyl transferase, family 2
E4O04_RS07455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4O04_RS07460	COG0706	membrane insertase activity
E4O04_RS07470	COG0297	glycogen (starch) synthase activity
E4O04_RS07475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4O04_RS07490	COG0124	histidyl-tRNA synthetase
E4O04_RS07500	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4O04_RS07515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4O04_RS07520	COG1132	(ABC) transporter
E4O04_RS07525	COG1132	(ABC) transporter
E4O04_RS07535	COG1162	GTPase activity
E4O04_RS07540	COG1193	negative regulation of DNA recombination
E4O04_RS07550	COG2190	(PTS) system
E4O04_RS07550	COG2211	Major facilitator Superfamily
E4O04_RS07560	COG0745	RESPONSE REGULATOR receiver
E4O04_RS07565	COG3292	Two component regulator propeller
E4O04_RS07565	COG2205	protein histidine kinase activity
E4O04_RS07565	COG0745	RESPONSE REGULATOR receiver
E4O04_RS07575	COG1136	(ABC) transporter
E4O04_RS07595	COG2604	Protein of unknown function DUF115
E4O04_RS07620	COG0009	L-threonylcarbamoyladenylate synthase
E4O04_RS07630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4O04_RS07640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4O04_RS07645	COG3437	response regulator, receiver
E4O04_RS07645	COG2770	Histidine kinase
E4O04_RS07655	COG0802	atpase or kinase
E4O04_RS07670	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4O04_RS07670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4O04_RS07680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O04_RS07685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O04_RS07720	COG0217	transcriptional regulatory protein
E4O04_RS07725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4O04_RS07740	COG0643	Histidine kinase
E4O04_RS07740	COG2198	Histidine kinase
E4O04_RS07745	COG0835	chemotaxis
E4O04_RS07755	COG2201	protein-glutamate methylesterase activity
E4O04_RS07765	COG1196	nuclear chromosome segregation
E4O04_RS07775	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4O04_RS07820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4O04_RS07830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O04_RS07830	COG0574	Belongs to the PEP-utilizing enzyme family
E4O04_RS07845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4O04_RS07850	COG0254	rRNA binding
E4O04_RS07860	COG1760	l-serine dehydratase
E4O04_RS07865	COG1760	l-serine dehydratase
E4O04_RS07875	COG1136	(ABC) transporter
E4O04_RS07880	COG0672	)-iron permease
E4O04_RS07885	COG3470	protein probably involved in high-affinity Fe2 transport
E4O04_RS07900	COG0577	efflux transmembrane transporter activity
E4O04_RS07905	COG1136	(ABC) transporter
E4O04_RS07935	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4O04_RS07965	COG1692	metallophosphoesterase
E4O04_RS07975	COG0142	geranyltranstransferase activity
E4O04_RS07985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4O04_RS08005	COG0727	PFAM Uncharacterised protein family (UPF0153)
E4O04_RS08020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4O04_RS08040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4O04_RS08045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4O04_RS08050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4O04_RS08055	COG0205	6-phosphofructokinase activity
E4O04_RS08060	COG0747	negative chemotaxis
E4O04_RS08065	COG0601	transmembrane transport
E4O04_RS08070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4O04_RS08075	COG0444	Belongs to the ABC transporter superfamily
E4O04_RS08080	COG4608	Belongs to the ABC transporter superfamily
E4O04_RS08085	COG0095	Lipoate-protein ligase
E4O04_RS08090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4O04_RS08095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O04_RS08120	COG2982	Protein involved in outer membrane biogenesis
E4O04_RS08125	COG3216	Uncharacterized protein conserved in bacteria (DUF2062)
E4O04_RS08130	COG0297	glycogen (starch) synthase activity
E4O04_RS08145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4O04_RS08155	COG0835	chemotaxis
E4O04_RS08165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4O04_RS08170	COG0488	(ABC) transporter
E4O04_RS08180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O04_RS08180	COG0493	'glutamate synthase
E4O04_RS08185	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4O04_RS08190	COG1129	ABC transporter
E4O04_RS08245	COG1051	belongs to the nudix hydrolase family
E4O04_RS08275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4O04_RS08295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4O04_RS08320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O04_RS08325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E4O04_RS08330	COG0509	glycine decarboxylation via glycine cleavage system
E4O04_RS08335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4O04_RS08340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4O04_RS08355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O04_RS08365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4O04_RS08370	COG1737	Transcriptional regulator
E4O04_RS08390	COG3052	prosthetic group binding
E4O04_RS08395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O04_RS08395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O04_RS08395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4O04_RS08400	COG0237	dephospho-CoA kinase activity
E4O04_RS08410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4O04_RS08415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4O04_RS08430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4O04_RS08455	COG1122	ATPase activity
E4O04_RS08460	COG1268	BioY protein
E4O04_RS08465	COG1132	(ABC) transporter
E4O04_RS08470	COG1132	(ABC) transporter
E4O04_RS08500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4O04_RS08505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4O04_RS08510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4O04_RS08515	COG0305	Participates in initiation and elongation during chromosome replication
E4O04_RS08535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4O04_RS08540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4O04_RS08550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E4O04_RS08570	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4O04_RS08575	COG0740	serine-type endopeptidase activity
E4O04_RS08580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4O04_RS08590	COG0359	binds to the 23S rRNA
E4O04_RS08595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4O04_RS08600	COG0629	single-stranded DNA binding
E4O04_RS08605	COG0360	Binds together with S18 to 16S ribosomal RNA
E4O04_RS08615	COG1269	ATP hydrolysis coupled proton transport
E4O04_RS08620	COG1394	ATPase activity, coupled to movement of substances
E4O04_RS08625	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4O04_RS08630	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4O04_RS08635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4O04_RS08640	COG2203	Gaf domain
E4O04_RS08640	COG4251	negative regulation of phosphorylation
E4O04_RS08640	COG5001	Diguanylate cyclase
E4O04_RS08640	COG3706	GGDEF domain
E4O04_RS08645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4O04_RS08650	COG0457	Tetratricopeptide repeat
E4O04_RS08660	COG1131	(ABC) transporter
E4O04_RS08680	COG0588	phosphoglycerate mutase activity
E4O04_RS08715	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4O04_RS08720	COG0776	regulation of translation
E4O04_RS08725	COG0268	Binds directly to 16S ribosomal RNA
E4O04_RS08745	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4O04_RS08750	COG0126	phosphoglycerate kinase activity
E4O04_RS08775	COG0519	Catalyzes the synthesis of GMP from XMP
E4O04_RS08790	COG0617	tRNA 3'-terminal CCA addition
E4O04_RS08815	COG3250	beta-galactosidase activity
E4O04_RS08820	COG0484	heat shock protein binding
E4O04_RS08825	COG0024	Methionine aminopeptidase
E4O04_RS08830	COG0708	Exodeoxyribonuclease III
E4O04_RS08840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O04_RS08850	COG0739	heme binding
E4O04_RS09100	COG2059	Chromate
E4O04_RS09105	COG0799	negative regulation of ribosome biogenesis
E4O04_RS09120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4O04_RS09125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4O04_RS09135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4O04_RS09140	COG2720	vancomycin resistance protein
E4O04_RS09150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4O04_RS09155	COG2033	superoxide reductase activity
E4O04_RS09190	COG0406	alpha-ribazole phosphatase activity
E4O04_RS09210	COG2226	methyltransferase
E4O04_RS09430	COG1136	(ABC) transporter
E4O04_RS09440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4O04_RS09480	COG0632	four-way junction helicase activity
E4O04_RS09485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4O04_RS09495	COG3271	cysteine-type peptidase activity
E4O04_RS09495	COG2274	protein secretion by the type I secretion system
E4O04_RS09540	COG0793	Belongs to the peptidase S41A family
E4O04_RS09550	COG0488	(ABC) transporter
E4O04_RS09585	COG2723	6-phospho-beta-galactosidase activity
E4O04_RS09600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4O04_RS09615	COG1114	Component of the transport system for branched-chain amino acids
E4O04_RS09645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4O04_RS09670	COG3451	type IV secretory pathway VirB4
E4O04_RS09695	COG2948	multi-organism process
E4O04_RS09745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4O04_RS09760	COG2003	Belongs to the UPF0758 family
E4O04_RS09805	COG0629	single-stranded DNA binding
E4O04_RS09860	COG0481	GTPase activity
E4O04_RS09870	COG2878	Part of a membrane complex involved in electron transport
E4O04_RS09870	COG1245	4Fe-4S binding domain
E4O04_RS09875	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4O04_RS09880	COG0138	bifunctional purine biosynthesis protein purh
E4O04_RS09885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4O04_RS09890	COG0653	protein targeting
E4O04_RS09895	COG1725	Transcriptional regulator
E4O04_RS09910	COG0736	holo-[acyl-carrier-protein] synthase activity
E4O04_RS09925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4O04_RS09940	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4O04_RS09950	COG2255	four-way junction helicase activity
E4O04_RS09955	COG1979	alcohol dehydrogenase
E4O04_RS09960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O04_RS09975	COG0731	radical SAM domain protein
E4O04_RS09990	COG1047	Peptidyl-prolyl cis-trans
E4O04_RS10030	COG0295	cytidine deaminase activity
E4O04_RS10050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4O04_RS10080	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4O04_RS10085	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4O04_RS10095	COG1744	ABC transporter substrate-binding protein PnrA-like
E4O04_RS10100	COG1234	tRNA 3'-trailer cleavage
E4O04_RS10120	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4O04_RS10135	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4O04_RS10140	COG2204	response regulator
E4O04_RS10145	COG3852	Histidine kinase
E4O04_RS10150	COG0470	DNA polymerase III
E4O04_RS10155	COG1286	toxin biosynthetic process
E4O04_RS10160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4O04_RS10210	COG4254	PFAM FecR protein
E4O04_RS10225	COG0823	Involved in the tonB-independent uptake of proteins
E4O04_RS10235	COG1199	ATP-dependent helicase activity
E4O04_RS10255	COG0606	chelatase, subunit chli
E4O04_RS10265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4O04_RS10270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4O04_RS10275	COG1164	Oligoendopeptidase f
E4O04_RS10280	COG0170	dolichyl monophosphate biosynthetic process
E4O04_RS10290	COG1233	COG1233 Phytoene dehydrogenase and related
E4O04_RS10295	COG1309	transcriptional regulator
E4O04_RS10320	COG1288	antiporter activity
E4O04_RS10330	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O04_RS10475	COG2885	chlorophyll binding
E4O04_RS10480	COG0084	hydrolase, TatD family'
E4O04_RS10490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4O04_RS10490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4O04_RS10500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4O04_RS10510	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E4O04_RS10515	COG3880	PFAM UvrB UvrC protein
E4O04_RS10525	COG1136	(ABC) transporter
E4O04_RS10530	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4O04_RS10540	COG0552	protein localization to endoplasmic reticulum
E4O04_RS10570	COG4166	transmembrane transport
E4O04_RS10610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4O04_RS10655	COG1918	ferrous iron import across plasma membrane
E4O04_RS10655	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E4O04_RS10660	COG1918	ferrous iron import across plasma membrane
E4O04_RS10685	COG1722	exodeoxyribonuclease VII activity
E4O04_RS10690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4O04_RS10700	COG0251	oxidation-reduction process
E4O04_RS10725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4O04_RS10745	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4O04_RS10750	COG2204	response regulator
E4O04_RS10770	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4O04_RS10775	COG0528	UMP kinase activity
E4O04_RS10780	COG0484	heat shock protein binding
E4O04_RS10785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4O04_RS10790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4O04_RS10795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4O04_RS10800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4O04_RS10805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4O04_RS10820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4O04_RS10825	COG3876	Protein conserved in bacteria
E4O04_RS10875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4O04_RS10885	COG0513	Belongs to the DEAD box helicase family
E4O04_RS10905	COG0284	orotidine-5'-phosphate decarboxylase activity
E4O04_RS10925	COG1131	(ABC) transporter
E4O04_RS10930	COG2770	Histidine kinase
E4O04_RS10930	COG2208	phosphoserine phosphatase activity
E4O04_RS10975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4O04_RS10985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4O04_RS11015	COG1122	ATPase activity
E4O04_RS11050	COG1770	oligopeptidase
E4O04_RS11060	COG4953	penicillin-binding protein 1C
E4O04_RS11065	COG3681	Belongs to the UPF0597 family
E4O04_RS11090	COG1388	LysM domain
E4O04_RS11090	COG0741	lytic transglycosylase activity
E4O04_RS11100	COG1671	Belongs to the UPF0178 family
E4O04_RS11105	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4O04_RS11115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4O04_RS11120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4O04_RS11165	COG1129	ABC transporter
E4O04_RS11180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4O04_RS11190	COG2738	Putative neutral zinc metallopeptidase
E4O04_RS11210	COG2226	methyltransferase
E4O04_RS11220	COG0798	PFAM Bile acid sodium symporter
E4O04_RS11235	COG0701	Predicted permease
E4O04_RS11240	COG0640	Transcriptional regulator
E4O04_RS11270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4O04_RS11275	COG0671	phosphoesterase, PA-phosphatase related
E4O04_RS11300	COG1022	Amp-dependent synthetase and ligase
E4O04_RS11305	COG1475	DNA binding
E4O04_RS11315	COG0739	heme binding
E4O04_RS11320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4O04_RS11320	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4O04_RS11340	COG0156	8-amino-7-oxononanoate synthase activity
E4O04_RS11345	COG0564	pseudouridine synthase activity
E4O04_RS11355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4O04_RS11355	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4O04_RS11355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4O04_RS11355	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4O04_RS11360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4O04_RS11365	COG0626	cystathionine gamma-synthase activity
E4O04_RS11380	COG1757	Na H antiporter
E4O04_RS11385	COG2056	Na+-H+ antiporter family
E4O04_RS11405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4O04_RS11410	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4O04_RS11415	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O04_RS11435	COG2226	methyltransferase
E4O04_RS11440	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4O04_RS11445	COG1129	ABC transporter
E4O04_RS11450	COG1879	ABC-type sugar transport system periplasmic component
E4O04_RS11470	COG0442	prolyl-tRNA aminoacylation
E4O04_RS11490	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4O04_RS11500	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O04_RS11515	COG1120	ATPase activity
E4O04_RS11520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O04_RS11535	COG4865	methylaspartate mutase activity
E4O04_RS11545	COG3142	Participates in the control of copper homeostasis
E4O04_RS11560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4O04_RS11595	COG2801	Transposase and inactivated derivatives
E4O04_RS11610	COG3956	TIGRFAM MazG family protein
E4O04_RS11615	COG0545	Peptidyl-prolyl cis-trans isomerase
E4O04_RS11620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4O04_RS11630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4O04_RS11630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O04_RS11635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4O04_RS11645	COG0546	phosphoglycolate phosphatase activity
E4O04_RS11655	COG0668	transmembrane transport
E4O04_RS11670	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4O04_RS11680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O04_RS11685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4O04_RS11695	COG0792	nuclease activity
E4O04_RS11710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4O04_RS11730	COG3604	Transcriptional regulator
E4O04_RS11735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4O04_RS11760	COG1272	protein, Hemolysin III
E4O04_RS11765	COG1196	nuclear chromosome segregation
E4O04_RS11765	COG0741	lytic transglycosylase activity
E4O04_RS11765	COG0739	heme binding
E4O04_RS11775	COG1595	DNA-templated transcription, initiation
E4O04_RS11790	COG0668	transmembrane transport
E4O04_RS11795	COG2197	response regulator
E4O04_RS11840	COG0542	response to heat
E4O04_RS11845	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4O04_RS11870	COG0210	DNA helicase
E4O04_RS11875	COG1132	(ABC) transporter
E4O04_RS11880	COG1132	(ABC) transporter
E4O04_RS11885	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4O04_RS11895	COG0495	leucyl-tRNA aminoacylation
E4O04_RS11905	COG0750	zinc metalloprotease
E4O04_RS11910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4O04_RS11915	COG0575	Belongs to the CDS family
E4O04_RS11920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4O04_RS11925	COG0233	cytoplasmic translational termination
E4O04_RS11930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4O04_RS11935	COG0052	Belongs to the universal ribosomal protein uS2 family
E4O04_RS11940	COG0424	maF-like protein
E4O04_RS11945	COG1413	lyase activity
E4O04_RS11965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4O04_RS11970	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E4O04_RS11975	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E4O04_RS11985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O04_RS11995	COG2376	Dihydroxyacetone kinase
E4O04_RS12000	COG2376	Dihydroxyacetone kinase
E4O04_RS12020	COG1757	Na H antiporter
E4O04_RS12030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4O04_RS12045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4O04_RS12065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4O04_RS12070	COG1131	(ABC) transporter
E4O04_RS12085	COG4585	Histidine kinase
E4O04_RS12095	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4O04_RS12105	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4O04_RS12145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4O04_RS12155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4O04_RS12155	COG0515	serine threonine protein kinase
E4O04_RS12180	COG0318	PFAM AMP-dependent synthetase and ligase
E4O04_RS12185	COG0791	NLP P60 protein
E4O04_RS12195	COG3735	TraB family
E4O04_RS12205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4O04_RS12210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4O04_RS12225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4O04_RS12230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4O04_RS12240	COG0534	Mate efflux family protein
E4O04_RS12245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4O04_RS12250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4O04_RS12255	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4O04_RS12270	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4O04_RS12280	COG0210	DNA helicase
E4O04_RS12340	COG0335	large ribosomal subunit rRNA binding
E4O04_RS12345	COG0336	Belongs to the RNA methyltransferase TrmD family
E4O04_RS12350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4O04_RS12355	COG1837	Belongs to the UPF0109 family
E4O04_RS12360	COG0228	four-way junction DNA binding
E4O04_RS12370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4O04_RS12375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4O04_RS12395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4O04_RS12400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4O04_RS12405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4O04_RS12410	COG0737	Belongs to the 5'-nucleotidase family
E4O04_RS12445	COG1285	pathogenesis
E4O04_RS12465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4O04_RS12470	COG1187	pseudouridine synthase activity
E4O04_RS12495	COG2197	response regulator
E4O04_RS12510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4O04_RS12545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4O04_RS12555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4O04_RS12555	COG0574	Belongs to the PEP-utilizing enzyme family
E4O04_RS12570	COG2304	oxidoreductase activity
E4O04_RS12580	COG1054	Belongs to the UPF0176 family
E4O04_RS12585	COG4656	Part of a membrane complex involved in electron transport
E4O04_RS12590	COG4658	electron transport chain
E4O04_RS12595	COG4659	FMN binding
E4O04_RS12600	COG4660	Part of a membrane complex involved in electron transport
E4O04_RS12605	COG4657	Part of a membrane complex involved in electron transport
E4O04_RS12615	COG1362	aminopeptidase activity
E4O04_RS12620	COG0445	tRNA wobble uridine modification
E4O04_RS12630	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4O04_RS12645	COG0626	cystathionine gamma-synthase activity
E4O04_RS12650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4O04_RS12655	COG1070	Carbohydrate kinase
E4O04_RS12660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4O04_RS12670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4O04_RS12690	COG1129	ABC transporter
E4O04_RS12695	COG1132	(ABC) transporter
E4O04_RS12700	COG1132	(ABC) transporter
E4O04_RS12710	COG1473	amidohydrolase
E4O04_RS12715	COG1288	antiporter activity
E4O04_RS12735	COG1741	Belongs to the pirin family
E4O04_RS12755	COG1132	(ABC) transporter
E4O04_RS12775	COG0840	transmembrane signaling receptor activity
E4O04_RS12795	COG4942	peptidase
E4O04_RS12800	COG0640	Transcriptional regulator
E4O04_RS12815	COG1131	(ABC) transporter
E4O04_RS12855	COG3339	Conserved Protein
E4O04_RS12870	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4O04_RS12890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4O04_RS12925	COG1690	Belongs to the RtcB family
E4O04_RS12930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4O04_RS12950	COG2910	NAD(P)H-binding
E4O04_RS12955	COG1959	2 iron, 2 sulfur cluster binding
E4O04_RS12980	COG1254	Belongs to the acylphosphatase family
E4O04_RS13000	COG0203	ribosomal protein L17
E4O04_RS13005	COG0202	RNA polymerase activity
E4O04_RS13010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4O04_RS13015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4O04_RS13020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4O04_RS13030	COG0200	Binds to the 23S rRNA
E4O04_RS13035	COG1841	ribosomal large subunit assembly
E4O04_RS13040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4O04_RS13045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4O04_RS13050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4O04_RS13055	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4O04_RS13060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4O04_RS13065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4O04_RS13070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4O04_RS13075	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4O04_RS13080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4O04_RS13085	COG0255	Belongs to the universal ribosomal protein uL29 family
E4O04_RS13090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4O04_RS13095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4O04_RS13100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4O04_RS13105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E4O04_RS13110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4O04_RS13115	COG0089	rRNA binding
E4O04_RS13120	COG0088	Forms part of the polypeptide exit tunnel
E4O04_RS13125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4O04_RS13130	COG0051	transcription antitermination factor activity, RNA binding
E4O04_RS13135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4O04_RS13165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O04_RS13170	COG1120	ATPase activity
E4O04_RS13175	COG1757	Na H antiporter
E4O04_RS13180	COG0135	phosphoribosylanthranilate isomerase activity
E4O04_RS13185	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4O04_RS13230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4O04_RS13240	COG3118	belongs to the thioredoxin family
E4O04_RS13290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4O04_RS13340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4O04_RS13385	COG1086	Polysaccharide biosynthesis protein
E4O04_RS13425	COG0330	HflC and HflK could
E4O04_RS13450	COG1131	(ABC) transporter
E4O04_RS13455	COG0351	phosphomethylpyrimidine kinase
E4O04_RS13465	COG0482	sulfurtransferase activity
E4O04_RS13480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4O04_RS13485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4O04_RS13490	COG0300	oxidoreductase activity
E4O04_RS13495	COG0629	single-stranded DNA binding
E4O04_RS13500	COG1862	Preprotein translocase
E4O04_RS13505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O04_RS13510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4O04_RS13515	COG1104	cysteine desulfurase activity
E4O04_RS13525	COG0425	Belongs to the sulfur carrier protein TusA family
E4O04_RS13560	COG3549	Plasmid maintenance system killer
E4O04_RS13580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4O04_RS13590	COG0719	Fe-S assembly protein
E4O04_RS13595	COG0396	ATPase activity
E4O04_RS13635	COG2211	Major facilitator Superfamily
E4O04_RS13665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4O04_RS13670	COG0546	phosphoglycolate phosphatase activity
E4O04_RS13680	COG2239	Acts as a magnesium transporter
E4O04_RS13690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4O04_RS13710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4O04_RS13715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4O04_RS13725	COG5001	Diguanylate cyclase
E4O04_RS13740	COG0084	hydrolase, TatD family'
E4O04_RS13745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4O04_RS13745	COG3116	cell division
E4O04_RS13785	COG0732	type I restriction modification DNA specificity domain
E4O04_RS13790	COG4974	Belongs to the 'phage' integrase family
E4O04_RS13795	COG0732	type I restriction modification DNA specificity domain
E4O04_RS13810	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E4O04_RS13830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4O04_RS13845	COG4545	Glutaredoxin-related protein
E4O04_RS13850	COG0739	heme binding
E4O04_RS13855	COG2423	ornithine cyclodeaminase activity
E4O04_RS13860	COG4166	transmembrane transport
E4O04_RS13865	COG1338	Plays a role in the flagellum-specific transport system
E4O04_RS13875	COG1776	CheC inhibitor of MCP methylation
E4O04_RS13875	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O04_RS13880	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4O04_RS13885	COG1580	Controls the rotational direction of flagella during chemotaxis
E4O04_RS13890	COG1360	Flagellar Motor Protein
E4O04_RS13895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4O04_RS13910	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4O04_RS13940	COG2986	histidine ammonia-lyase
E4O04_RS13945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4O04_RS13950	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4O04_RS13970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4O04_RS13975	COG1120	ATPase activity
E4O04_RS13980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4O04_RS14030	COG1132	(ABC) transporter
E4O04_RS14035	COG1132	(ABC) transporter
E4O04_RS14060	COG0587	DNA-directed DNA polymerase activity