locus-tag class description GWP43_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GWP43_RS00015 ENOG4105EXW epimerase dehydratase GWP43_RS00020 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GWP43_RS00060 ENOG4108HUF Transporter GWP43_RS00065 ENOG4105EHG Permease protein GWP43_RS00070 ENOG4105E0A ABC, transporter GWP43_RS00075 ENOG4107SCN K03215 23S rRNA (uracil1939-C5)-methyltransferase EC 2.1.1.190 GWP43_RS00095 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GWP43_RS00100 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GWP43_RS00110 ENOG4105BZ1 (ABC) transporter GWP43_RS00125 ENOG4105D29 Helix-turn-helix type 11 domain protein GWP43_RS00130 ENOG4105D85 methylase GWP43_RS00135 ENOG4105D85 methylase GWP43_RS00165 ENOG4105KRQ Addiction module toxin, Txe YoeB family GWP43_RS00170 ENOG4105BZ1 (ABC) transporter GWP43_RS00180 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GWP43_RS00205 ENOG41090Q2 GWP43_RS00240 ENOG4107GZ4 SanA protein GWP43_RS00275 ENOG4105VFE sira family GWP43_RS00300 ENOG4105BZF Glycosyl transferase (Group 1 GWP43_RS00305 ENOG4105C5H ABC transporter GWP43_RS00320 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS00325 ENOG4105C72 UPF0176 protein GWP43_RS00330 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GWP43_RS00335 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GWP43_RS00355 ENOG4105DR5 peptidase GWP43_RS00375 ENOG4108JJB ABC transporter GWP43_RS00500 ENOG4107S6Z Na H antiporter GWP43_RS00505 ENOG4105BZU Histidine kinase GWP43_RS00510 ENOG4105BZU Histidine kinase GWP43_RS00580 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GWP43_RS00585 ENOG4105ID8 Transcriptional regulator, ARAC family GWP43_RS00600 ENOG4108JJB ABC transporter GWP43_RS00605 ENOG41083MR nifu domain-containing protein GWP43_RS00625 ENOG4105BZ1 (ABC) transporter GWP43_RS00630 ENOG4105BZ1 (ABC) transporter GWP43_RS00635 ENOG4105C59 p-type ATPase GWP43_RS00655 ENOG4105C59 p-type ATPase GWP43_RS00675 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GWP43_RS00705 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWP43_RS00725 ENOG4105DAP Nicotinate phosphoribosyltransferase GWP43_RS00760 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for GWP43_RS00765 ENOG4105C31 Tryptophanyl-tRNA synthetase GWP43_RS00770 ENOG4105HFZ Membrane GWP43_RS00785 ENOG4107YZD Protein of unknown function DUF115 GWP43_RS00790 ENOG4105CJN penicillin-binding protein GWP43_RS00795 ENOG4105C3F Signal peptidase i GWP43_RS01210 ENOG4108JA2 transcriptioN-repair coupling factor GWP43_RS01215 ENOG4105IJJ transcriptional regulator, crp fnr family GWP43_RS01225 ENOG4105DB7 PHP domain protein GWP43_RS01235 ENOG4105EZ5 reductase GWP43_RS01250 ENOG4105C98 muts2 protein GWP43_RS01260 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GWP43_RS01305 ENOG41082Y9 Single-strand binding protein GWP43_RS01315 ENOG4105C6K Malic enzyme GWP43_RS01320 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GWP43_RS01360 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GWP43_RS01370 ENOG4105C1J atp-dependent rna helicase GWP43_RS01380 ENOG4105DRS transport system, permease GWP43_RS01385 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GWP43_RS01395 ENOG4108UMI ABC transporter, permease GWP43_RS01405 ENOG4105C0H protease GWP43_RS01410 ENOG4105F8J Adenylate Guanylate cyclase GWP43_RS01420 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GWP43_RS01430 ENOG4105DWF phosphomethylpyrimidine kinase GWP43_RS01445 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GWP43_RS01455 ENOG4107I03 GWP43_RS01490 ENOG4105CGH 5'-nucleotidase GWP43_RS01500 ENOG41069D7 Methyl-accepting chemotaxis GWP43_RS01510 ENOG4105DZW Dipeptidase GWP43_RS01515 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS01525 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GWP43_RS01540 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GWP43_RS01545 ENOG4105RKW reductase (By GWP43_RS01550 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) GWP43_RS01555 ENOG4105D6A Electron transport complex GWP43_RS01560 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit GWP43_RS01565 ENOG4105DZB Electron transport complex GWP43_RS01570 ENOG4105DGN Electron transport complex GWP43_RS01575 ENOG4108R3D Electron transport complex GWP43_RS01580 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GWP43_RS01585 ENOG4105FAV ABC, transporter GWP43_RS01590 ENOG4105IW6 Carbamoyltransferase GWP43_RS01595 ENOG4107S4Y M20 DapE family protein YgeY GWP43_RS01605 ENOG4105HA9 of methanol dehydrogenase type GWP43_RS01620 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GWP43_RS01635 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GWP43_RS01645 ENOG4105D3R alkyl hydroperoxide reductase GWP43_RS01655 ENOG41084MZ 50S ribosomal protein L35 GWP43_RS01665 ENOG4106BH8 GWP43_RS01670 ENOG4106BMT Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GWP43_RS01675 ENOG41082MQ UPF0178 protein GWP43_RS01680 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GWP43_RS01685 ENOG4105CIN aminoacyl-histidine dipeptidase GWP43_RS01690 ENOG4105BZG amino acid carrier protein GWP43_RS01695 ENOG4107QSA Oxaloacetate decarboxylase GWP43_RS01700 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GWP43_RS01705 ENOG4105VXN addiction module toxin, RelE StbE family GWP43_RS01730 ENOG4105DA5 (ABC) transporter GWP43_RS01750 ENOG4105D1H recombination factor protein RarA GWP43_RS01755 ENOG4106VGM (LipO)protein GWP43_RS01760 ENOG4105XBK GWP43_RS01770 ENOG4106VF0 GWP43_RS01785 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) GWP43_RS01825 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GWP43_RS01840 ENOG4105FDK ABC transporter GWP43_RS01845 ENOG4108HU6 Metal dependent phosphohydrolase GWP43_RS01850 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein GWP43_RS01860 ENOG4105C0F tryptophanase EC 4.1.99.1 GWP43_RS01865 ENOG4105C8J )-transporter GWP43_RS01870 ENOG4108SSC basic membrane GWP43_RS01880 ENOG4108TWB ABC transporter (Permease GWP43_RS01910 ENOG4108JU6 CBS domain protein GWP43_RS01920 ENOG4108HM4 ABC transporter GWP43_RS01925 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GWP43_RS01960 ENOG4105C26 Dehydrogenase GWP43_RS01965 ENOG41069M3 Transcriptional regulator GWP43_RS01970 ENOG4105EI2 Pseudouridine synthase GWP43_RS01975 ENOG41089XN GWP43_RS01985 ENOG4105C1J atp-dependent rna helicase GWP43_RS01990 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GWP43_RS01995 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GWP43_RS02000 ENOG4105CHR reductase GWP43_RS02005 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GWP43_RS02070 ENOG41067SE Tetr family transcriptional regulator GWP43_RS02085 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GWP43_RS02090 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GWP43_RS02135 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GWP43_RS02140 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GWP43_RS02145 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein GWP43_RS02165 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GWP43_RS02170 ENOG4107XHD Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GWP43_RS02175 ENOG4105MJ2 Competence protein GWP43_RS02210 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GWP43_RS02215 ENOG4105KZ7 phosphocarrier protein hpr GWP43_RS02225 ENOG4105DK7 lysyl-tRNA synthetase GWP43_RS02230 ENOG4107V28 uracil phosphoribosyltransferase GWP43_RS02235 ENOG4106VIZ GWP43_RS02240 ENOG4105C8J )-transporter GWP43_RS02270 ENOG4108Z4J Cytidine monophosphate kinase GWP43_RS02305 ENOG4105CSM endonuclease III GWP43_RS02345 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GWP43_RS02350 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GWP43_RS02355 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GWP43_RS02360 ENOG41071ZZ GWP43_RS02365 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GWP43_RS02385 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GWP43_RS02400 ENOG4108IG5 Transcriptional regulator GWP43_RS02425 ENOG4108JJB ABC transporter GWP43_RS02475 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GWP43_RS02510 ENOG4105DBV ornithine carbamoyltransferase GWP43_RS02515 ENOG4105C5B carbamate kinase GWP43_RS02520 ENOG4105CSX c4-dicarboxylate anaerobic carrier GWP43_RS02525 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GWP43_RS02530 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GWP43_RS02660 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GWP43_RS02675 ENOG4105G3C Type iv pilus assembly GWP43_RS02695 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GWP43_RS02700 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GWP43_RS02710 ENOG4108JQ6 ABC transporter GWP43_RS02725 ENOG4105BZ1 (ABC) transporter GWP43_RS02760 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GWP43_RS02765 ENOG4105DFM M18 family aminopeptidase GWP43_RS02800 ENOG4105E4P ATPase (AAA GWP43_RS02805 ENOG4105J5G Transferase hexapeptide repeat containing protein GWP43_RS02815 ENOG4107RZX Teichoic acid biosynthesis protein GWP43_RS02830 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GWP43_RS02835 ENOG4107QQG Dehydrogenase GWP43_RS02850 ENOG4107QRS glycosyltransferase group 2 family protein GWP43_RS02860 ENOG4105DMT epimerase dehydratase GWP43_RS02875 ENOG4105Z8J GWP43_RS02885 ENOG41080E8 Transcriptional regulator, Spx MgsR family GWP43_RS02960 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GWP43_RS02965 ENOG4107QJE Chromosome Partitioning Protein GWP43_RS02970 ENOG4105FA0 parb-like partition protein GWP43_RS02980 ENOG4105CK7 Sodium proline symporter GWP43_RS02985 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GWP43_RS03010 ENOG41067D0 Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2 GWP43_RS03050 ENOG41080ET plasmid maintenance system killer protein GWP43_RS03055 ENOG4105VDM plasmid maintenance system antidote protein, xre family GWP43_RS03065 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GWP43_RS03070 ENOG4106447 Preprotein translocase subunit SecG GWP43_RS03080 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GWP43_RS03085 ENOG4105CTQ phosphohexokinase GWP43_RS03090 ENOG4105CUT histidyl-tRNA synthetase GWP43_RS03095 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GWP43_RS03100 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GWP43_RS03105 ENOG4105W0I repeat-containing protein GWP43_RS03115 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS03165 ENOG4105DTJ flagellar hook-associated protein GWP43_RS03180 ENOG4105CGA flagellar basal-body rod protein FlgG GWP43_RS03185 ENOG4105CGA flagellar basal-body rod protein FlgG GWP43_RS03190 ENOG410680E Flagellar protein GWP43_RS03205 ENOG4105E0A ABC, transporter GWP43_RS03210 ENOG4105EHG Permease protein GWP43_RS03225 ENOG4105DVA methyltransferase GWP43_RS03235 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GWP43_RS03265 ENOG4105KME endoribonuclease L-psp GWP43_RS03280 ENOG4108YZY peptidylprolyl cis-trans isomerase GWP43_RS03285 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GWP43_RS03295 ENOG4105K46 50S ribosomal protein l27 GWP43_RS03300 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GWP43_RS03310 ENOG4108H0C adenylyltransferase EC 2.7.7.18 GWP43_RS03330 ENOG410854D Required for maturation of 30S ribosomal subunits (By similarity) GWP43_RS03335 ENOG4105CHV Transcription elongation factor NusA GWP43_RS03340 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GWP43_RS03345 ENOG41080JB Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GWP43_RS03355 ENOG4105DTN riboflavin biosynthesis protein ribF GWP43_RS03370 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GWP43_RS03385 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS03390 ENOG4107RCQ (CBS) domain GWP43_RS03405 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS03415 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GWP43_RS03425 ENOG4105K95 (LipO)protein GWP43_RS03455 ENOG41067XK integral membrane protein GWP43_RS03470 ENOG4107R2W ABC transporter, permease GWP43_RS03475 ENOG4105C2J ABC transporter GWP43_RS03490 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator GWP43_RS03500 ENOG4105CB5 ATP-dependent DNA helicase recG GWP43_RS03510 ENOG4105CFP Peptidase U32 GWP43_RS03530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GWP43_RS03540 ENOG4108JQ7 (ABC) transporter GWP43_RS03545 ENOG4105D07 Signal peptide peptidase, SppA GWP43_RS03565 ENOG4105EMN RNA polymerase sigma factor GWP43_RS03585 ENOG41084P6 50S ribosomal protein l28 GWP43_RS03595 ENOG4105SFS phosphoesterase RecJ domain protein GWP43_RS03610 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GWP43_RS03660 ENOG4105KRQ Addiction module toxin, Txe YoeB family GWP43_RS03675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GWP43_RS03695 ENOG4108YZG isomerase GWP43_RS03710 ENOG4105BZ1 (ABC) transporter GWP43_RS03720 ENOG4105KRQ Addiction module toxin, Txe YoeB family GWP43_RS03735 ENOG4105CIG ABC transporter GWP43_RS03770 ENOG4105RHY Pfam:UPF0157 GWP43_RS03820 ENOG410822I Flagellar hook capping protein GWP43_RS03825 ENOG4105BZE flagellar hook protein, FlgE GWP43_RS03840 ENOG4107XSU flagellar motor protein motb GWP43_RS03845 ENOG41064SM flagellar basal body-associated protein flil GWP43_RS03850 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GWP43_RS03855 ENOG4105DD5 Flagellar motor switch protein GWP43_RS03865 ENOG4105CN7 Flagellar biosynthetic protein FliP GWP43_RS03870 ENOG4105VS8 Flagellar biosynthetic protein fliq GWP43_RS03875 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GWP43_RS03880 ENOG4105D00 flagellar biosynthetic protein flhB GWP43_RS03885 ENOG4105D7B Flagellar biosynthesis protein flha GWP43_RS03890 ENOG4105FZW flagellar biosynthesis regulator FlhF GWP43_RS03900 ENOG4105UQX Mate efflux family protein GWP43_RS03915 ENOG4105DFM M18 family aminopeptidase GWP43_RS03925 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GWP43_RS03930 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GWP43_RS03950 ENOG41090QV Protein of unknown function DUF115 GWP43_RS03960 ENOG410698I GWP43_RS03975 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GWP43_RS03980 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GWP43_RS03985 ENOG4105C79 DNA protecting protein DprA GWP43_RS03995 ENOG4107RWR Sodium hydrogen exchanger GWP43_RS04000 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GWP43_RS04010 ENOG4108SDV Periplasmic Protein GWP43_RS04025 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GWP43_RS04030 ENOG4105C19 ABC transporter GWP43_RS04040 ENOG4105D5T phosphonate abc transporter GWP43_RS04070 ENOG4105CDY transcriptional regulatory protein GWP43_RS04075 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GWP43_RS04080 ENOG4105C9U ATP-dependent DNA helicase RecQ GWP43_RS04085 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GWP43_RS04100 ENOG4106XCQ Inherit from COG: Pfam:DUF82 GWP43_RS04120 ENOG4105JTB GWP43_RS04125 ENOG4106FRC GWP43_RS04195 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GWP43_RS04215 ENOG4105CFF transcriptional regulator GWP43_RS04295 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GWP43_RS04320 ENOG4105D82 Glutamate dehydrogenase GWP43_RS04325 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GWP43_RS04340 ENOG4105WYW fructose-bisphosphate aldolase GWP43_RS04355 ENOG4105CJ2 (LipO)protein GWP43_RS04370 ENOG4105D01 (LipO)protein GWP43_RS04380 ENOG4105F8V Hydrolase, tatD family GWP43_RS04385 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GWP43_RS04395 ENOG4105Y6R GWP43_RS04410 ENOG4105I76 (LipO)protein GWP43_RS04415 ENOG4105C5H ABC transporter GWP43_RS04430 ENOG4105CE4 GlcNAc 6-P deacetylase GWP43_RS04435 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GWP43_RS04440 ENOG4105F4G Membrane GWP43_RS04445 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GWP43_RS04450 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GWP43_RS04455 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GWP43_RS04490 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GWP43_RS04510 ENOG4107GFK fumarate GWP43_RS04745 ENOG4108ES9 ParB domain protein nuclease GWP43_RS04750 ENOG4105FA0 parb-like partition protein GWP43_RS04990 ENOG41085YX 50S ribosomal protein L32 GWP43_RS04995 ENOG41084E5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GWP43_RS05150 ENOG4105DFA alanine racemase domain protein GWP43_RS05155 ENOG41085YX 50S ribosomal protein L32 GWP43_RS05160 ENOG41084E5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GWP43_RS05165 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GWP43_RS05200 ENOG4105C10 Electron transfer flavoprotein GWP43_RS05205 ENOG4105C1G acyl-Coa dehydrogenase GWP43_RS05210 ENOG4108JUB Transcriptional regulator GWP43_RS05215 ENOG4105E39 Enoyl-CoA hydratase GWP43_RS05220 ENOG4105CY2 Citrate transporter GWP43_RS05230 ENOG4105C1G acyl-Coa dehydrogenase GWP43_RS05235 ENOG4105C10 Electron transfer flavoprotein GWP43_RS05245 ENOG4108JIR Flagellum-specific ATP synthase GWP43_RS05250 ENOG4105W2B Flagellar assembly protein GWP43_RS05255 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GWP43_RS05260 ENOG4107U2N Flagellar M-ring protein GWP43_RS05270 ENOG4108ZC9 flagellar basal-body rod protein flgc GWP43_RS05275 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GWP43_RS05280 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GWP43_RS05285 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GWP43_RS05290 ENOG4105CTZ aminopeptidase c GWP43_RS05295 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GWP43_RS05300 ENOG4107QP8 phosphohexose isomerase GWP43_RS05305 ENOG4105ESV Glycosyl transferase, family 4 GWP43_RS05310 ENOG4107RCH Diaminopropionate ammonia-lyase GWP43_RS05325 ENOG4105CY0 Metallo-Beta-Lactamase GWP43_RS05330 ENOG4105C2N RNA methyltransferase TrmH family group 3 GWP43_RS05335 ENOG4105EIB trna rrna methyltransferase GWP43_RS05340 ENOG4107QJD pyruvate phosphate dikinase GWP43_RS05345 ENOG4108SXE GWP43_RS05350 ENOG41073RW Cytoplasmic filament protein A GWP43_RS05355 ENOG4105YQK von Willebrand factor type A domain GWP43_RS05360 ENOG4106BN6 GWP43_RS05365 ENOG4105CHU acetyl-coa acetyltransferase GWP43_RS05375 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GWP43_RS05390 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GWP43_RS05405 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS05410 ENOG4105H1G trap transporter solute receptor taxi family GWP43_RS05420 ENOG4105CGK Exodeoxyribonuclease III GWP43_RS05430 ENOG4105WD1 Membrane GWP43_RS05435 ENOG4108IUZ ABC transporter GWP43_RS05455 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GWP43_RS05470 ENOG4105E0A ABC, transporter GWP43_RS05475 ENOG4105EHG Permease protein GWP43_RS05500 ENOG4105DN3 alpha-2-macroglobulin domain protein GWP43_RS05540 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GWP43_RS05545 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GWP43_RS05550 ENOG4105DNX Dna topoisomerase iv (Subunit b) GWP43_RS05555 ENOG4107QYI peptidase GWP43_RS05560 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GWP43_RS05565 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS05585 ENOG41081IW Inherit from COG: Membrane GWP43_RS05595 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWP43_RS05600 ENOG4105DJ0 Poly(A) Polymerase GWP43_RS05605 ENOG410828M hemerythrin-like, metal-binding protein GWP43_RS05610 ENOG4108IUM Glycogen debranching enzyme GWP43_RS05615 ENOG4107FKK extracellular solute-binding protein family 1 GWP43_RS05635 ENOG4105EG2 ABC transporter, permease GWP43_RS05660 ENOG41080XV Thioredoxin GWP43_RS05670 ENOG4105CBS Chea signal transduction histidine kinase GWP43_RS05675 ENOG4105YFD chemotaxis, protein GWP43_RS05685 ENOG4107Z9R response regulator GWP43_RS05700 ENOG4108ZVA radical SAM domain protein GWP43_RS05720 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GWP43_RS05730 ENOG4107NGC Flagellar filament outer layer protein GWP43_RS05740 ENOG41086BH Binds directly to 16S ribosomal RNA (By similarity) GWP43_RS05750 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GWP43_RS05755 ENOG4107RI4 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GWP43_RS05765 ENOG4105CEV competence damage-inducible protein GWP43_RS05770 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GWP43_RS05775 ENOG41082DI 50s ribosomal protein l31 GWP43_RS05780 ENOG4108UT2 hemolysin iii GWP43_RS05795 ENOG4105CJ1 ABC, transporter GWP43_RS05805 ENOG4105BZU Histidine kinase GWP43_RS05820 ENOG4105C19 ABC transporter GWP43_RS05880 ENOG4108JJB ABC transporter GWP43_RS05885 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GWP43_RS05895 ENOG4108V1U phospholipid-binding protein GWP43_RS05900 ENOG4107UIE peptidase GWP43_RS05990 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GWP43_RS06030 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GWP43_RS06035 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GWP43_RS06040 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GWP43_RS06045 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS06050 ENOG4105D17 glycoside hydrolase, family 3 domain protein GWP43_RS06055 ENOG4105EHZ conserved protein UCP016719 GWP43_RS06060 ENOG4106XHX GWP43_RS06070 ENOG4105E9H Lytic Murein transglycosylase GWP43_RS06095 ENOG4106N3A copper homeostasis protein cutc GWP43_RS06115 ENOG4105CV1 Transketolase (EC 2.2.1.1) GWP43_RS06120 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GWP43_RS06135 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GWP43_RS06145 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GWP43_RS06165 ENOG4105DFW ABC transporter GWP43_RS06175 ENOG4105CNN ABC, transporter GWP43_RS06180 ENOG4105CMG Carbohydrate kinase GWP43_RS06185 ENOG4105C93 Xylose Isomerase GWP43_RS06195 ENOG4106ARS GWP43_RS06205 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GWP43_RS06210 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GWP43_RS06235 ENOG4105DQ6 Transposase GWP43_RS06270 ENOG4105DZW Dipeptidase GWP43_RS06290 ENOG4105C8B TIGR00159 family GWP43_RS06300 ENOG41083V3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GWP43_RS06305 ENOG4108CER Uncharacterized protein conserved in bacteria (DUF2225) GWP43_RS06310 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GWP43_RS06315 ENOG4105CKI cobalamin synthesis protein GWP43_RS06325 ENOG4108ZB6 transcriptional regulator AsnC family GWP43_RS06330 ENOG4105CHM Aminotransferase GWP43_RS06335 ENOG4108KP7 hydrolase GWP43_RS06345 ENOG4108JQ7 (ABC) transporter GWP43_RS06350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GWP43_RS06355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GWP43_RS06390 ENOG4105ZF0 Lipoprotein GWP43_RS06400 ENOG4108JJB ABC transporter GWP43_RS06420 ENOG4106MPK GWP43_RS06425 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GWP43_RS06435 ENOG4105D60 lipoprotein releasing system transmembrane protein GWP43_RS06440 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GWP43_RS06450 ENOG4105EAH synthase GWP43_RS06460 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GWP43_RS06555 ENOG4107XI7 Tetr family transcriptional regulator GWP43_RS06745 ENOG4105BZ1 (ABC) transporter GWP43_RS06750 ENOG4105BZ1 (ABC) transporter GWP43_RS06755 ENOG4105BZ1 (ABC) transporter GWP43_RS06760 ENOG4105BZ1 (ABC) transporter GWP43_RS06775 ENOG4108JQB penicillin-binding protein 1C GWP43_RS06790 ENOG41062BZ domain protein GWP43_RS06800 ENOG4106GEY GWP43_RS06810 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GWP43_RS06820 ENOG4105C8J )-transporter GWP43_RS06830 ENOG4108QUE repeat-containing protein GWP43_RS06835 ENOG4108V0P LemA family GWP43_RS06840 ENOG4108IG5 Transcriptional regulator GWP43_RS06845 ENOG4105BZ1 (ABC) transporter GWP43_RS06850 ENOG4105BZ1 (ABC) transporter GWP43_RS06865 ENOG4105DRR Transcriptional regulator, GntR family GWP43_RS06870 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GWP43_RS06875 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GWP43_RS06880 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GWP43_RS06885 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GWP43_RS06895 ENOG4107QRG dna polymerase iii GWP43_RS06910 ENOG4105CDU Replicative dna helicase GWP43_RS06915 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GWP43_RS06920 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GWP43_RS06925 ENOG4105Z8H single-stranded DNA-binding protein GWP43_RS06930 ENOG41084AY Binds together with S18 to 16S ribosomal RNA (By similarity) GWP43_RS06950 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GWP43_RS06955 ENOG4105C3J Cysteine desulfurase GWP43_RS06960 ENOG4105D49 3-dehydroquinate synthase GWP43_RS06975 ENOG4107SGM protein serine threonine phosphatase GWP43_RS06980 ENOG41082AN stage II sporulation protein GWP43_RS07015 ENOG4105PGM cation diffusion facilitator family transporter GWP43_RS07025 ENOG4105KST dependent repressor GWP43_RS07030 ENOG4105DSE periplasmic solute binding protein GWP43_RS07035 ENOG4105DIK (ABC) transporter GWP43_RS07040 ENOG4105CC5 ABC transporter GWP43_RS07050 ENOG4105EWC Purine nucleoside phosphorylase GWP43_RS07060 ENOG41066A3 ATP guanido phosphotransferase GWP43_RS07070 ENOG4108JUB Transcriptional regulator GWP43_RS07095 ENOG4105BZU Histidine kinase GWP43_RS07105 ENOG4105MB2 GWP43_RS07125 ENOG4105HCZ GWP43_RS07155 ENOG4105CP7 Triose-phosphate isomerase GWP43_RS07165 ENOG4105EJQ L-serine dehydratase GWP43_RS07185 ENOG4108IY2 MazG family GWP43_RS07190 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GWP43_RS07200 ENOG4106SUR Protein of unknown function DUF115 GWP43_RS07245 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GWP43_RS07260 ENOG4105CMG Carbohydrate kinase GWP43_RS07280 ENOG410830R acetyltransferase GWP43_RS07305 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GWP43_RS07330 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GWP43_RS07365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWP43_RS07395 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GWP43_RS07400 ENOG4106S4G GWP43_RS07405 ENOG4107ZYR domain protein GWP43_RS07410 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GWP43_RS07435 ENOG4105DAN ATP-dependent protease GWP43_RS07455 ENOG4108M1M outer membrane lipoprotein-sorting protein GWP43_RS07475 ENOG4107R3N Filamentation induced by cAMP protein fic GWP43_RS07480 ENOG4108JJB ABC transporter GWP43_RS07505 ENOG4105CJ1 ABC, transporter GWP43_RS07540 ENOG4108IG5 Transcriptional regulator GWP43_RS07565 ENOG4108JJB ABC transporter GWP43_RS07595 ENOG4105X1A GWP43_RS07600 ENOG41062Z1 GWP43_RS07605 ENOG4105DZP Membrane-associated zinc metalloprotease GWP43_RS07610 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GWP43_RS07620 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GWP43_RS07625 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GWP43_RS07630 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GWP43_RS07635 ENOG4105CE9 30S ribosomal protein S2 GWP43_RS07640 ENOG4108Z03 MAF-like protein GWP43_RS07650 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GWP43_RS07665 ENOG41085BT Protein of unknown function (DUF1312) GWP43_RS07670 ENOG4105D78 K07001 NTE family protein GWP43_RS07675 ENOG4105YFD chemotaxis, protein GWP43_RS07685 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GWP43_RS07690 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GWP43_RS07740 ENOG4105CYC Transferase GWP43_RS07745 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GWP43_RS07750 ENOG41083MR nifu domain-containing protein GWP43_RS07775 ENOG4107S8T NAD-dependent 4-hydroxybutyrate dehydrogenase GWP43_RS07790 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GWP43_RS07800 ENOG4105J3I GWP43_RS07805 ENOG4105F8J Adenylate Guanylate cyclase GWP43_RS07810 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GWP43_RS07815 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GWP43_RS07820 ENOG4107I15 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GWP43_RS07830 ENOG4105CT4 transporter GWP43_RS07865 ENOG4105CEM UPF0597 protein GWP43_RS07870 ENOG4108IYC Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GWP43_RS07895 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GWP43_RS07915 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GWP43_RS07920 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GWP43_RS07925 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GWP43_RS07935 ENOG41083HS Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GWP43_RS07940 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GWP43_RS07945 ENOG4108JDX DNA polymerase iii, epsilon subunit GWP43_RS07960 ENOG4108JQC penicillin-binding protein 1A GWP43_RS07980 ENOG41089UC methyltransferase, type 11 GWP43_RS07985 ENOG4105C0D helicase GWP43_RS08000 ENOG41080VC Galactokinase (EC 2.7.1.6) GWP43_RS08005 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GWP43_RS08010 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GWP43_RS08055 ENOG4107QMP dna polymerase iii subunits gamma and tau GWP43_RS08060 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GWP43_RS08085 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GWP43_RS08095 ENOG4105CUZ uba thif-type nad fad binding protein GWP43_RS08100 ENOG4107QKZ Ompa motb domain protein GWP43_RS08105 ENOG4105D3R alkyl hydroperoxide reductase GWP43_RS08185 ENOG4107S85 alpha-2-macroglobulin domain protein GWP43_RS08195 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GWP43_RS08200 ENOG4107QIV Cytochrome c biogenesis protein GWP43_RS08210 ENOG4105K4H Nlp p60 protein GWP43_RS08215 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GWP43_RS08230 ENOG41068UM RNA Polymerase GWP43_RS08255 ENOG4105CIH Imidazole acetol-phosphate transaminase GWP43_RS08275 ENOG4108Z66 YbaK ebsC protein GWP43_RS08280 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GWP43_RS08290 ENOG4107TT5 NLP P60 protein GWP43_RS08300 ENOG4105BZ4 penicillin-binding protein GWP43_RS08330 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GWP43_RS08360 ENOG4105K5M 30s ribosomal protein S16 GWP43_RS08365 ENOG4105VB6 UPF0109 protein GWP43_RS08370 ENOG4107GQ3 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GWP43_RS08375 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GWP43_RS08380 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GWP43_RS08395 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GWP43_RS08420 ENOG4105VCQ rubredoxin GWP43_RS08440 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GWP43_RS08460 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) GWP43_RS08470 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GWP43_RS08490 ENOG4105VUH addiction module killer protein GWP43_RS08495 ENOG4105YES addiction module antidote protein GWP43_RS08505 ENOG4105C22 threonyL-tRNA synthetase GWP43_RS08530 ENOG4105DQ6 Transposase GWP43_RS08565 ENOG4105DQ6 Transposase GWP43_RS08590 ENOG4105DQ6 Transposase GWP43_RS08675 ENOG4108JJ9 ABC, transporter GWP43_RS08680 ENOG4105BZ1 (ABC) transporter GWP43_RS08685 ENOG4108T5G Adenylate GWP43_RS08705 ENOG4108UVJ appr-1-p processing domain protein GWP43_RS08715 ENOG4105CVA phosphate GWP43_RS08720 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GWP43_RS08725 ENOG4105C34 Pseudouridine synthase GWP43_RS08770 ENOG4105EPW hflc protein GWP43_RS08775 ENOG4107RIZ hflk protein GWP43_RS08795 ENOG4105C5I Dehydrogenase GWP43_RS08850 ENOG4105VDM plasmid maintenance system antidote protein, xre family GWP43_RS08875 ENOG4109015 Biopolymer transport protein exbD tolR GWP43_RS08900 ENOG4107WGG Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GWP43_RS08910 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GWP43_RS08945 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GWP43_RS08955 ENOG4105FE9 pseudouridine synthase GWP43_RS08965 ENOG4105DR9 pseudouridine synthase GWP43_RS08975 ENOG4105MBR gumn family GWP43_RS08985 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GWP43_RS08995 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GWP43_RS09000 ENOG4105CNI cell division protein FtsW GWP43_RS09005 ENOG4108APS Essential cell division protein (By similarity) GWP43_RS09010 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GWP43_RS09015 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GWP43_RS09035 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GWP43_RS09040 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GWP43_RS09060 ENOG4105CFC Transporter GWP43_RS09070 ENOG41067SE Tetr family transcriptional regulator GWP43_RS09085 ENOG4105G9E GWP43_RS09090 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GWP43_RS09095 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component GWP43_RS09110 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GWP43_RS09115 ENOG4105RD7 BadF BadG BcrA BcrD GWP43_RS09120 ENOG4108NJY Repeat protein GWP43_RS09145 ENOG4107SCJ type I restriction enzyme EcoKI subunit R GWP43_RS09160 ENOG4107QTH restriction modification system DNA specificity domain GWP43_RS09200 ENOG4107QTH restriction modification system DNA specificity domain GWP43_RS09210 ENOG4105C4R Atp-dependent dna helicase GWP43_RS09365 ENOG4105C6Y Udp-glucose 6-dehydrogenase GWP43_RS09380 ENOG4105XN3 extracellular solute-binding protein family 1 GWP43_RS09395 ENOG4105VVB GWP43_RS09405 ENOG41062VP GWP43_RS09410 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GWP43_RS09415 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GWP43_RS09420 ENOG4105SXG GWP43_RS09435 ENOG4105DG6 mannose-6-phosphate isomerase GWP43_RS09440 ENOG4105C25 Primosomal protein n' GWP43_RS09445 ENOG4108UN4 phage SPO1 DNA polymerase-related protein GWP43_RS09465 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GWP43_RS09470 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GWP43_RS09480 ENOG4105CNI cell division protein FtsW GWP43_RS09485 ENOG4105CJN penicillin-binding protein GWP43_RS09500 ENOG4105DFF Rod shape-determining protein mreb GWP43_RS09520 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWP43_RS09525 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GWP43_RS09550 ENOG4105K78 MarR family Transcriptional regulator GWP43_RS09565 ENOG4106S0F GWP43_RS09590 ENOG4107QMG Nad synthetase GWP43_RS09595 ENOG4106B9X GWP43_RS09600 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GWP43_RS09620 ENOG4105DJV ribulose-phosphate 3-epimerase GWP43_RS09625 ENOG4105T73 GWP43_RS09645 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GWP43_RS09650 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GWP43_RS09655 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GWP43_RS09660 ENOG4108KS2 transglutaminase domain protein GWP43_RS09670 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWP43_RS09675 ENOG4105C8N cysteinyl-tRNA synthetase GWP43_RS09680 ENOG4107QWW Cell wall formation (By similarity) GWP43_RS09700 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GWP43_RS09705 ENOG4105BZU Histidine kinase GWP43_RS09710 ENOG41090KZ GWP43_RS09740 ENOG4105BZA Phosphoglycerate kinase GWP43_RS09785 ENOG4105EU2 peptidase U61 LD-carboxypeptidase A GWP43_RS09805 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GWP43_RS09815 ENOG4105CEY Amp-dependent synthetase and ligase GWP43_RS09825 ENOG4108Y51 tRNA-binding protein GWP43_RS09830 ENOG4105CNW domain protein GWP43_RS09855 ENOG4105C37 (CBS) domain GWP43_RS09860 ENOG41082QW Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GWP43_RS09865 ENOG4105CTJ Metal Dependent Phosphohydrolase GWP43_RS09885 ENOG4105M6F mutator MutT protein GWP43_RS09890 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GWP43_RS09900 ENOG4106UV5 membrane protein A GWP43_RS09920 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase GWP43_RS09925 ENOG4105CMH dehydratase GWP43_RS09930 ENOG4105CIZ coA-substrate-specific enzyme activase GWP43_RS09935 ENOG4105D6U Sodium Glutamate Symporter GWP43_RS09940 ENOG4107QX3 carboxylase GWP43_RS09945 ENOG4107UHT Glutaconate CoA-transferase GWP43_RS09955 ENOG4105D9Q decarboxylase (Beta subunit) GWP43_RS09970 ENOG4105D6U Sodium Glutamate Symporter GWP43_RS09975 ENOG4105C5I Dehydrogenase GWP43_RS09980 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GWP43_RS09985 ENOG41061XC GWP43_RS09990 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GWP43_RS10000 ENOG41069X2 GWP43_RS10005 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GWP43_RS10010 ENOG4107TVT This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GWP43_RS10020 ENOG4105K4W Could be involved in septation (By similarity) GWP43_RS10030 ENOG4105K59 histidine triad (HIT) protein GWP43_RS10035 ENOG4108IQE Amp-dependent synthetase and ligase GWP43_RS10045 ENOG4105CGH 5'-nucleotidase GWP43_RS10065 ENOG4105C9U ATP-dependent DNA helicase RecQ GWP43_RS10080 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GWP43_RS10090 ENOG4105CPT Alpha beta hydrolase GWP43_RS10115 ENOG4107XI7 Tetr family transcriptional regulator GWP43_RS10125 ENOG4105BZ1 (ABC) transporter GWP43_RS10130 ENOG4108JJB ABC transporter GWP43_RS10145 ENOG4108I0C methyltransferase GWP43_RS10165 ENOG4105YA8 Transcriptional regulator GWP43_RS10190 ENOG4105E89 ABC transporter GWP43_RS10195 ENOG4105EAB amino acid AbC transporter GWP43_RS10210 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GWP43_RS10225 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GWP43_RS10230 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GWP43_RS10235 ENOG4108VZM 50s ribosomal protein L10 GWP43_RS10240 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GWP43_RS10245 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GWP43_RS10250 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GWP43_RS10265 ENOG41084ED 50S ribosomal protein L33 GWP43_RS10280 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GWP43_RS10285 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GWP43_RS10310 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GWP43_RS10320 ENOG4105CU9 asparagine synthetase A GWP43_RS10350 ENOG4105DR5 peptidase GWP43_RS10365 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GWP43_RS10375 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GWP43_RS10385 ENOG410805Y Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GWP43_RS10395 ENOG4105DR5 peptidase GWP43_RS10410 ENOG4105MA4 psp1 domain protein GWP43_RS10430 ENOG4105E2X shikimate dehydrogenase GWP43_RS10435 ENOG4105E66 phosphoriboisomerase A GWP43_RS10440 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GWP43_RS10455 ENOG4105E39 Enoyl-CoA hydratase GWP43_RS10460 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GWP43_RS10465 ENOG4107Z3H Transcriptional regulator, TetR family GWP43_RS10485 ENOG4105C4Y ABC transporter GWP43_RS10495 ENOG4107RCV ABC transporter, permease GWP43_RS10500 ENOG4106KNT transcriptional regulator GWP43_RS10510 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GWP43_RS10515 ENOG4105CD3 dihydroorotase GWP43_RS10520 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GWP43_RS10525 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GWP43_RS10530 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GWP43_RS10535 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GWP43_RS10540 ENOG4105CXT aspartate transcarbamylase GWP43_RS10550 ENOG4105VXR cytoplasmic protein GWP43_RS10565 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GWP43_RS10575 ENOG4105BZ1 (ABC) transporter GWP43_RS10580 ENOG4105C9M aspartyl-trna synthetase GWP43_RS10585 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) GWP43_RS10605 ENOG4105VXP Protein of unknown function DUF86 GWP43_RS10655 ENOG4105UIB (ABC) transporter GWP43_RS10660 ENOG4108JQ9 ABC transporter GWP43_RS10665 ENOG4107TFB basic membrane GWP43_RS10670 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS10695 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GWP43_RS10700 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GWP43_RS10705 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GWP43_RS10730 ENOG4105C3F Signal peptidase i GWP43_RS10735 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS10745 ENOG4105ZFX GWP43_RS10770 ENOG4108ETT Dehydrogenase GWP43_RS10775 ENOG4108TGK Low-potential electron donor to a number of redox enzymes (By similarity) GWP43_RS10780 ENOG41090E6 transcriptional regulator MERR family GWP43_RS10855 ENOG4105C1G acyl-Coa dehydrogenase GWP43_RS10860 ENOG4105C26 Dehydrogenase GWP43_RS10870 ENOG4108TSD Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GWP43_RS10885 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GWP43_RS10910 ENOG4105CFI type iii restriction protein res subunit GWP43_RS10915 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GWP43_RS10925 ENOG4105K8N protein family UPF0079, ATPase GWP43_RS10930 ENOG4105EMS pseudouridine synthase GWP43_RS10940 ENOG4107W7Y Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GWP43_RS10980 ENOG4108RVA ribokinase GWP43_RS10985 ENOG4108RVA ribokinase GWP43_RS10990 ENOG4105DU0 nucleoside hydrolase GWP43_RS11005 ENOG4108JQ9 ABC transporter GWP43_RS11010 ENOG4105DIH basic membrane GWP43_RS11025 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GWP43_RS11040 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GWP43_RS11085 ENOG4105DIW FeS assembly protein SUFB GWP43_RS11095 ENOG4105C9B Cysteine desulfurase GWP43_RS11100 ENOG4105D48 metallophosphoesterase GWP43_RS11130 ENOG4108IJG ABC transporter substrate-binding protein GWP43_RS11150 ENOG4105KG3 cytidine deaminase GWP43_RS11155 ENOG410684W GWP43_RS11165 ENOG4108UHU Aldolase GWP43_RS11185 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GWP43_RS11200 ENOG4105EHZ conserved protein UCP016719 GWP43_RS11205 ENOG4105CJW magnesium transporter GWP43_RS11215 ENOG4106SWD GWP43_RS11230 ENOG4105BZ1 (ABC) transporter GWP43_RS11245 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A GWP43_RS11250 ENOG4105XMH SpoVT AbrB domain protein GWP43_RS11255 ENOG41067SE Tetr family transcriptional regulator GWP43_RS11260 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GWP43_RS11260 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GWP43_RS11285 ENOG4108I5C dEAD DEAH box helicase GWP43_RS11310 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GWP43_RS11315 ENOG4105CFG Acts as a chaperone (By similarity) GWP43_RS11320 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GWP43_RS11355 ENOG4105DF5 DNA topoisomerase IV, subunit A GWP43_RS11360 ENOG4105CQ4 Transcriptional regulator GWP43_RS11385 ENOG4105CNT hydrolase family 2 GWP43_RS11395 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GWP43_RS11400 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GWP43_RS11410 ENOG4105ES5 Histidine kinase GWP43_RS11415 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GWP43_RS11425 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) GWP43_RS11445 ENOG4105K56 Transcriptional regulator GWP43_RS11465 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWP43_RS11470 ENOG4105ECY inositol monophosphatase GWP43_RS11485 ENOG4105ENE Histidine kinase GWP43_RS11565 ENOG4108KSB HipA-like N-terminal domain GWP43_RS11575 ENOG4108RZE Tetr family transcriptional regulator GWP43_RS11590 ENOG4108JJB ABC transporter GWP43_RS11655 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GWP43_RS11675 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GWP43_RS11680 ENOG4108RY1 ATP synthase, subunit E GWP43_RS11695 ENOG4107RQX Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit GWP43_RS11700 ENOG4108WBK V-type ATP synthase subunit D GWP43_RS11705 ENOG4107U1W v-type ATP synthase subunit I GWP43_RS11720 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GWP43_RS11730 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GWP43_RS11750 ENOG4105DVT helicase GWP43_RS11755 ENOG4106QD2 GWP43_RS11770 ENOG4105CSA Coproporphyrinogen iii oxidase GWP43_RS11785 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GWP43_RS11795 ENOG4108JQ7 (ABC) transporter GWP43_RS11805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GWP43_RS11820 ENOG4105VDM plasmid maintenance system antidote protein, xre family GWP43_RS11825 ENOG4105KVH Transcriptional regulator GWP43_RS11870 ENOG41086D8 Transcriptional regulator GWP43_RS11880 ENOG4108HR6 Dehydrogenase GWP43_RS11885 ENOG4105C7W Xanthine dehydrogenase GWP43_RS11890 ENOG4105CPN adenine deaminase GWP43_RS11895 ENOG4107QUY Guanine deaminase GWP43_RS11930 ENOG4107QTH restriction modification system DNA specificity domain GWP43_RS11940 ENOG4105MZU cell filamentation protein GWP43_RS11970 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GWP43_RS11975 ENOG4105C0H protease GWP43_RS11985 ENOG4106AHS GWP43_RS11990 ENOG410835P This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GWP43_RS12020 ENOG4106XJW GWP43_RS12040 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GWP43_RS12050 ENOG4106N2C GWP43_RS12055 ENOG4105I03 Flagellin GWP43_RS12060 ENOG4105C98 muts2 protein GWP43_RS12065 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GWP43_RS12075 ENOG4105D7A ATP-binding protein GWP43_RS12080 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GWP43_RS12085 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GWP43_RS12105 ENOG4107QHI -hydrogenase GWP43_RS12120 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit GWP43_RS12195 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GWP43_RS12200 ENOG4107MD5 glycoside hydrolase, family GWP43_RS12205 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GWP43_RS12230 ENOG4105CN1 protease GWP43_RS12255 ENOG4105VDM plasmid maintenance system antidote protein, xre family GWP43_RS12265 ENOG4106DC9 GWP43_RS12270 ENOG4108ZT0 50S ribosomal protein l17 GWP43_RS12275 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GWP43_RS12280 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GWP43_RS12290 ENOG41067V7 50S ribosomal protein L36 GWP43_RS12295 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GWP43_RS12300 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GWP43_RS12310 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GWP43_RS12325 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GWP43_RS12335 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GWP43_RS12340 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GWP43_RS12345 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GWP43_RS12350 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GWP43_RS12355 ENOG41086S0 50s ribosomal protein l29 GWP43_RS12365 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GWP43_RS12380 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GWP43_RS12385 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GWP43_RS12390 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GWP43_RS12395 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GWP43_RS12400 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GWP43_RS12405 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GWP43_RS12420 ENOG4108RIR Molybdenum cofactor biosynthesis protein GWP43_RS12425 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GWP43_RS12430 ENOG4105E0C molybdate abc transporter GWP43_RS12465 ENOG4105E4C Lytic transglycosylase catalytic GWP43_RS12470 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GWP43_RS12475 ENOG4105CNU cell division protein FtsK GWP43_RS12480 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS12500 ENOG4107Z25 Basic membrane protein GWP43_RS12510 ENOG4105F8V Hydrolase, tatD family GWP43_RS12520 ENOG4105K6T rare lipoprotein A GWP43_RS12810 ENOG4107YVC modification (methylase) GWP43_RS12850 ENOG4105Z8H single-stranded DNA-binding protein GWP43_RS12915 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GWP43_RS12925 ENOG4105CFP Peptidase U32 GWP43_RS12935 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GWP43_RS12940 ENOG4105C34 Pseudouridine synthase GWP43_RS12965 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GWP43_RS12980 ENOG4105VUN Transcriptional regulator GWP43_RS12990 ENOG41067S9 phage shock protein C, PspC GWP43_RS13040 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GWP43_RS13045 ENOG41077G2 GWP43_RS13050 ENOG4105CMR udp-glucose 4-epimerase GWP43_RS13055 ENOG4107S1W 4-alpha-glucanotransferase GWP43_RS13075 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GWP43_RS13095 ENOG4105VEM Conserved domain protein GWP43_RS13140 ENOG4105EI2 Pseudouridine synthase GWP43_RS13170 ENOG4108M1M outer membrane lipoprotein-sorting protein GWP43_RS13185 ENOG4107RFY SbcCD D subunit GWP43_RS13190 ENOG4105DSE periplasmic solute binding protein GWP43_RS13205 ENOG4105CJR Integral membrane protein (MviN GWP43_RS13215 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GWP43_RS13225 ENOG4105CQ7 ATP-dependent helicase GWP43_RS13230 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GWP43_RS13240 ENOG4106SAP GWP43_RS13245 ENOG4107VE5 flagellar hook-associated protein GWP43_RS13250 ENOG4105I03 Flagellin GWP43_RS13255 ENOG4105I03 Flagellin GWP43_RS13280 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GWP43_RS13370 ENOG4105CVR type I restriction-modification system GWP43_RS13545 ENOG4106RHC GWP43_RS13555 ENOG4105C3M thioredoxin reductase GWP43_RS13560 ENOG4105D17 glycoside hydrolase, family 3 domain protein GWP43_RS13565 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) GWP43_RS13575 ENOG41083NY Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GWP43_RS13585 ENOG4105DR5 peptidase GWP43_RS13600 ENOG4105CKU formyltetrahydrofolate synthetase GWP43_RS13605 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GWP43_RS13625 ENOG4106W1H GWP43_RS13630 ENOG4105D38 putrescine abc transporter GWP43_RS13635 ENOG4105F38 ABC transporter, permease GWP43_RS13640 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GWP43_RS13645 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GWP43_RS13650 ENOG4108PJD permease GWP43_RS13670 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GWP43_RS13695 ENOG4105TQV GWP43_RS13700 ENOG4105C3G gtp-binding protein GWP43_RS13705 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GWP43_RS13715 ENOG4105VN1 Heat shock protein GWP43_RS13720 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GWP43_RS13725 ENOG4108Z29 Flavodoxin GWP43_RS13735 ENOG4108ZGC gaf domain protein GWP43_RS13745 ENOG410624X efflux transporter, rnd family, mfp subunit GWP43_RS13750 ENOG4105C19 ABC transporter GWP43_RS13765 ENOG410667J hydrolase GWP43_RS13780 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GWP43_RS13790 ENOG4105C8Q Methyl-accepting chemotaxis GWP43_RS13795 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GWP43_RS13800 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GWP43_RS13810 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GWP43_RS13815 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GWP43_RS13825 ENOG4105CTQ phosphohexokinase GWP43_RS13830 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GWP43_RS13845 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GWP43_RS13850 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GWP43_RS13865 ENOG4105DPN Oligoendopeptidase f GWP43_RS13890 ENOG4105D98 threonine synthase GWP43_RS13895 ENOG4106KG8 GWP43_RS13915 ENOG4105C5X domain protein GWP43_RS13925 ENOG41073FS GWP43_RS13945 ENOG4105DR5 peptidase GWP43_RS13955 ENOG4108V1T peptidylprolyl cis-trans isomerase GWP43_RS13965 ENOG4105D29 Helix-turn-helix type 11 domain protein GWP43_RS14000 ENOG4105EJ2 Transcriptional regulator GWP43_RS14015 ENOG4108JJB ABC transporter GWP43_RS14025 ENOG4105BZ1 (ABC) transporter GWP43_RS14065 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GWP43_RS14095 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GWP43_RS14100 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GWP43_RS14105 ENOG4105D2T synthase GWP43_RS14130 ENOG4105C87 Aminotransferase class I and II