locus-tag	class	description
GWP40_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWP40_RS00030	COG1177	transmembrane transport
GWP40_RS00035	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWP40_RS00040	COG3842	ATPase activity
GWP40_RS00055	COG1744	ABC transporter substrate-binding protein PnrA-like
GWP40_RS00060	COG1129	ABC transporter
GWP40_RS00065	COG4603	Belongs to the binding-protein-dependent transport system permease family
GWP40_RS00070	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWP40_RS00075	COG4942	peptidase
GWP40_RS00090	COG3177	Filamentation induced by cAMP protein fic
GWP40_RS00110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWP40_RS00115	COG1253	flavin adenine dinucleotide binding
GWP40_RS00120	COG4536	flavin adenine dinucleotide binding
GWP40_RS00130	COG3118	belongs to the thioredoxin family
GWP40_RS00135	COG1692	metallophosphoesterase
GWP40_RS00140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWP40_RS00160	COG0719	Fe-S assembly protein
GWP40_RS00200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWP40_RS00210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWP40_RS00220	COG0039	L-malate dehydrogenase activity
GWP40_RS00235	COG0500	methyltransferase
GWP40_RS00240	COG1132	(ABC) transporter
GWP40_RS00240	COG2375	cellular response to nickel ion
GWP40_RS00255	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GWP40_RS00275	COG0534	Mate efflux family protein
GWP40_RS00285	COG1309	transcriptional regulator
GWP40_RS00310	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWP40_RS00315	COG1024	Enoyl-CoA hydratase
GWP40_RS00320	COG0427	acetyl-CoA hydrolase
GWP40_RS00360	COG0203	ribosomal protein L17
GWP40_RS00365	COG0202	RNA polymerase activity
GWP40_RS00370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWP40_RS00380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWP40_RS00400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWP40_RS00410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWP40_RS00415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWP40_RS00425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWP40_RS00430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWP40_RS00435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWP40_RS00440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWP40_RS00445	COG0255	Belongs to the universal ribosomal protein uL29 family
GWP40_RS00455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWP40_RS00460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWP40_RS00470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWP40_RS00475	COG0089	rRNA binding
GWP40_RS00480	COG0088	Forms part of the polypeptide exit tunnel
GWP40_RS00485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWP40_RS00490	COG0051	transcription antitermination factor activity, RNA binding
GWP40_RS00495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWP40_RS00510	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWP40_RS00515	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWP40_RS00520	COG4149	molybdate abc transporter
GWP40_RS00585	COG0741	lytic transglycosylase activity
GWP40_RS00590	COG1968	undecaprenyl-diphosphatase activity
GWP40_RS00595	COG1674	ftsk spoiiie
GWP40_RS00615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWP40_RS00625	COG0084	hydrolase, TatD family'
GWP40_RS00635	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWP40_RS00690	COG0714	Associated with various cellular activities
GWP40_RS00715	COG3621	Patatin-like phospholipase
GWP40_RS00745	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GWP40_RS00750	COG0826	peptidase U32
GWP40_RS00775	COG0822	iron-sulfur transferase activity
GWP40_RS00780	COG2255	four-way junction helicase activity
GWP40_RS00790	COG0445	tRNA wobble uridine modification
GWP40_RS00800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWP40_RS00820	COG1757	Na H antiporter
GWP40_RS00825	COG2199	diguanylate cyclase activity
GWP40_RS00825	COG2203	Gaf domain
GWP40_RS00830	COG3706	GGDEF domain
GWP40_RS00850	COG0488	(ABC) transporter
GWP40_RS00855	COG0438	transferase activity, transferring glycosyl groups
GWP40_RS00855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWP40_RS00870	COG0673	inositol 2-dehydrogenase activity
GWP40_RS00875	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWP40_RS00880	COG1129	ABC transporter
GWP40_RS00885	COG1879	ABC-type sugar transport system periplasmic component
GWP40_RS00905	COG0191	fructose-bisphosphate aldolase activity
GWP40_RS00910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWP40_RS00920	COG1349	DNA-binding transcription factor activity
GWP40_RS00925	COG1012	belongs to the aldehyde dehydrogenase family
GWP40_RS00940	COG0425	Belongs to the sulfur carrier protein TusA family
GWP40_RS00965	COG0733	neurotransmitter:sodium symporter activity
GWP40_RS00980	COG0543	2 iron, 2 sulfur cluster binding
GWP40_RS00985	COG1639	'signal transduction protein
GWP40_RS00990	COG1121	(ABC) transporter
GWP40_RS00995	COG1695	Transcriptional regulator
GWP40_RS01005	COG1983	PspC domain protein
GWP40_RS01055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWP40_RS01055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP40_RS01055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP40_RS01065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWP40_RS01085	COG4452	Inner membrane protein CreD
GWP40_RS01090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWP40_RS01115	COG2885	chlorophyll binding
GWP40_RS01120	COG0739	heme binding
GWP40_RS01130	COG1114	Component of the transport system for branched-chain amino acids
GWP40_RS01135	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GWP40_RS01140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWP40_RS01145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWP40_RS01150	COG0423	glycine-tRNA ligase activity
GWP40_RS01160	COG0584	glycerophosphoryl diester phosphodiesterase
GWP40_RS01170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWP40_RS01170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWP40_RS01180	COG0205	6-phosphofructokinase activity
GWP40_RS01195	COG1028	Short-chain dehydrogenase reductase Sdr
GWP40_RS01200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWP40_RS01205	COG2204	response regulator
GWP40_RS01245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWP40_RS01280	COG0640	Transcriptional regulator
GWP40_RS01295	COG0110	maltose O-acetyltransferase activity
GWP40_RS01375	COG0484	heat shock protein binding
GWP40_RS01380	COG0024	Methionine aminopeptidase
GWP40_RS01415	COG2089	acid synthase
GWP40_RS01420	COG0592	DNA-directed DNA polymerase activity
GWP40_RS01425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWP40_RS01480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWP40_RS01555	COG2378	regulation of single-species biofilm formation
GWP40_RS01560	COG1002	Type II restriction enzyme, methylase subunits
GWP40_RS01570	COG2815	serine threonine protein kinase
GWP40_RS01570	COG0515	serine threonine protein kinase
GWP40_RS01580	COG1132	(ABC) transporter
GWP40_RS01590	COG0545	Peptidyl-prolyl cis-trans isomerase
GWP40_RS01595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWP40_RS01600	COG1881	PFAM PEBP family protein
GWP40_RS01630	COG0739	heme binding
GWP40_RS01635	COG1686	Belongs to the peptidase S11 family
GWP40_RS01655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWP40_RS01660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWP40_RS01715	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWP40_RS01715	COG3608	succinylglutamate desuccinylase aspartoacylase
GWP40_RS01725	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWP40_RS01740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWP40_RS01745	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GWP40_RS01810	COG1131	(ABC) transporter
GWP40_RS01830	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP40_RS01835	COG0511	ligase activity, forming carbon-carbon bonds
GWP40_RS01835	COG5016	pyruvate
GWP40_RS01840	COG1115	amino acid carrier protein
GWP40_RS01845	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWP40_RS01850	COG3437	response regulator, receiver
GWP40_RS01855	COG1671	Belongs to the UPF0178 family
GWP40_RS01860	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GWP40_RS01875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWP40_RS01895	COG0351	phosphomethylpyrimidine kinase
GWP40_RS01910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP40_RS01915	COG1120	ATPase activity
GWP40_RS01920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWP40_RS01925	COG3585	molybdate ion transport
GWP40_RS01950	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GWP40_RS01955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP40_RS01965	COG2011	ABC-type metal ion transport system permease component
GWP40_RS01975	COG1879	ABC-type sugar transport system periplasmic component
GWP40_RS01985	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWP40_RS01990	COG1129	ABC transporter
GWP40_RS02000	COG1070	Carbohydrate kinase
GWP40_RS02020	COG1175	transmembrane transport
GWP40_RS02025	COG0395	ABC-type sugar transport system, permease component
GWP40_RS02045	COG0840	transmembrane signaling receptor activity
GWP40_RS02110	COG0037	tRNA processing
GWP40_RS02155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP40_RS02160	COG4977	sequence-specific DNA binding
GWP40_RS02160	COG1917	Cupin 2, conserved barrel domain protein
GWP40_RS02175	COG1129	ABC transporter
GWP40_RS02180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWP40_RS02200	COG0739	heme binding
GWP40_RS02225	COG1129	ABC transporter
GWP40_RS02280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWP40_RS02295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWP40_RS02300	COG0156	8-amino-7-oxononanoate synthase activity
GWP40_RS02335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GWP40_RS02340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP40_RS02345	COG1120	ATPase activity
GWP40_RS02350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWP40_RS02375	COG1193	negative regulation of DNA recombination
GWP40_RS02385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GWP40_RS02430	COG0629	single-stranded DNA binding
GWP40_RS02435	COG0281	malic enzyme
GWP40_RS02440	COG0513	Belongs to the DEAD box helicase family
GWP40_RS02445	COG0438	transferase activity, transferring glycosyl groups
GWP40_RS02480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWP40_RS02485	COG0706	membrane insertase activity
GWP40_RS02490	COG1847	R3H domain protein
GWP40_RS02500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWP40_RS02505	COG1862	Preprotein translocase
GWP40_RS02510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWP40_RS02515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWP40_RS02520	COG1040	competence protein
GWP40_RS02530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWP40_RS02540	COG0058	SHG alpha-glucan phosphorylase activity
GWP40_RS02555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GWP40_RS02560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP40_RS02570	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GWP40_RS02575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWP40_RS02580	COG0457	Tetratricopeptide repeat
GWP40_RS02585	COG0733	neurotransmitter:sodium symporter activity
GWP40_RS02590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWP40_RS02605	COG0519	Catalyzes the synthesis of GMP from XMP
GWP40_RS02640	COG0481	GTPase activity
GWP40_RS02655	COG0018	arginyl-trna synthetase
GWP40_RS02660	COG2235	arginine
GWP40_RS02665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWP40_RS02675	COG1288	antiporter activity
GWP40_RS02685	COG0653	protein targeting
GWP40_RS02700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWP40_RS02715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWP40_RS02765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWP40_RS02770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWP40_RS02775	COG0783	Belongs to the Dps family
GWP40_RS02780	COG0326	Molecular chaperone. Has ATPase activity
GWP40_RS02790	COG0681	Belongs to the peptidase S26 family
GWP40_RS02800	COG0740	serine-type endopeptidase activity
GWP40_RS02805	COG1744	ABC transporter substrate-binding protein PnrA-like
GWP40_RS02815	COG4603	Belongs to the binding-protein-dependent transport system permease family
GWP40_RS02820	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWP40_RS02920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWP40_RS02925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWP40_RS02930	COG2203	Gaf domain
GWP40_RS02930	COG4251	negative regulation of phosphorylation
GWP40_RS02930	COG5001	Diguanylate cyclase
GWP40_RS02930	COG3706	GGDEF domain
GWP40_RS02935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP40_RS02940	COG0205	6-phosphofructokinase activity
GWP40_RS02945	COG4211	Belongs to the binding-protein-dependent transport system permease family
GWP40_RS02950	COG1129	ABC transporter
GWP40_RS02955	COG1879	ABC-type sugar transport system periplasmic component
GWP40_RS02970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWP40_RS02975	COG0012	GTP binding
GWP40_RS03010	COG1028	Short-chain dehydrogenase reductase Sdr
GWP40_RS03020	COG0789	Transcriptional regulator
GWP40_RS03020	COG4978	Transcriptional regulator
GWP40_RS03025	COG1288	antiporter activity
GWP40_RS03035	COG1288	antiporter activity
GWP40_RS03040	COG2887	Belongs to the helicase family. UvrD subfamily
GWP40_RS03050	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GWP40_RS03065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWP40_RS03095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP40_RS03160	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GWP40_RS03200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWP40_RS03225	COG1136	(ABC) transporter
GWP40_RS03225	COG0577	efflux transmembrane transporter activity
GWP40_RS03265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWP40_RS03290	COG2183	response to ionizing radiation
GWP40_RS03325	COG0395	ABC-type sugar transport system, permease component
GWP40_RS03330	COG4209	transmembrane transport
GWP40_RS03350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWP40_RS03355	COG1570	exodeoxyribonuclease VII activity
GWP40_RS03375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWP40_RS03385	COG0450	alkyl hydroperoxide reductase
GWP40_RS03395	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GWP40_RS03400	COG0071	Belongs to the small heat shock protein (HSP20) family
GWP40_RS03405	COG0019	diaminopimelate decarboxylase activity
GWP40_RS03410	COG0716	FMN binding
GWP40_RS03420	COG1956	GAF domain-containing protein
GWP40_RS03430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP40_RS03440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWP40_RS03445	COG2878	Part of a membrane complex involved in electron transport
GWP40_RS03445	COG1245	4Fe-4S binding domain
GWP40_RS03450	COG4657	Part of a membrane complex involved in electron transport
GWP40_RS03465	COG4659	FMN binding
GWP40_RS03470	COG4658	electron transport chain
GWP40_RS03480	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWP40_RS03495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWP40_RS03500	COG0825	malonyl-CoA metabolic process
GWP40_RS03510	COG0540	Belongs to the ATCase OTCase family
GWP40_RS03515	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWP40_RS03520	COG0543	2 iron, 2 sulfur cluster binding
GWP40_RS03525	COG0167	dihydroorotate dehydrogenase activity
GWP40_RS03530	COG0284	orotidine-5'-phosphate decarboxylase activity
GWP40_RS03535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWP40_RS03540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWP40_RS03550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWP40_RS03560	COG0613	PHP domain protein
GWP40_RS03650	COG0564	pseudouridine synthase activity
GWP40_RS03655	COG0588	phosphoglycerate mutase activity
GWP40_RS03680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWP40_RS03705	COG0419	ATPase involved in DNA repair
GWP40_RS03715	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWP40_RS03720	COG1757	Na H antiporter
GWP40_RS03730	COG0728	peptidoglycan biosynthetic process
GWP40_RS03740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWP40_RS03770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWP40_RS03770	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GWP40_RS03775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP40_RS03780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP40_RS03795	COG0459	protein refolding
GWP40_RS03820	COG0280	phosphate acetyltransferase
GWP40_RS03825	COG0492	ferredoxin-NADP+ reductase activity
GWP40_RS03830	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP40_RS03835	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GWP40_RS03840	COG1966	Carbon starvation protein
GWP40_RS03890	COG1102	Psort location Cytoplasmic, score
GWP40_RS03900	COG0840	transmembrane signaling receptor activity
GWP40_RS03905	COG0793	Belongs to the peptidase S41A family
GWP40_RS03945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWP40_RS03965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GWP40_RS04025	COG0762	integral membrane protein
GWP40_RS04030	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GWP40_RS04035	COG0180	Tryptophanyl-tRNA synthetase
GWP40_RS04040	COG0670	Belongs to the BI1 family
GWP40_RS04055	COG0322	excinuclease ABC activity
GWP40_RS04085	COG1774	PSP1 C-terminal conserved region
GWP40_RS04100	COG0739	heme binding
GWP40_RS04110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWP40_RS04115	COG2911	Protein conserved in bacteria
GWP40_RS04120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWP40_RS04155	COG0739	heme binding
GWP40_RS04190	COG2502	aspartate--ammonia ligase
GWP40_RS04200	COG0301	tRNA thio-modification
GWP40_RS04215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWP40_RS04235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP40_RS04265	COG1193	negative regulation of DNA recombination
GWP40_RS04330	COG2604	Protein of unknown function DUF115
GWP40_RS04335	COG0768	penicillin binding
GWP40_RS04355	COG0494	nUDIX hydrolase
GWP40_RS04380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWP40_RS04385	COG0457	Tetratricopeptide repeat
GWP40_RS04390	COG1418	mRNA catabolic process
GWP40_RS04450	COG1132	(ABC) transporter
GWP40_RS04460	COG1132	(ABC) transporter
GWP40_RS04470	COG1132	(ABC) transporter
GWP40_RS04470	COG2375	cellular response to nickel ion
GWP40_RS04475	COG4977	sequence-specific DNA binding
GWP40_RS04475	COG1917	Cupin 2, conserved barrel domain protein
GWP40_RS04485	COG0747	negative chemotaxis
GWP40_RS04490	COG0601	transmembrane transport
GWP40_RS04495	COG0601	transmembrane transport
GWP40_RS04505	COG4172	Belongs to the ABC transporter superfamily
GWP40_RS04555	COG1120	ATPase activity
GWP40_RS04560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP40_RS04630	COG0402	S-adenosylhomocysteine deaminase activity
GWP40_RS04640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWP40_RS04645	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWP40_RS04665	COG2207	Transcriptional regulator
GWP40_RS04665	COG3708	Transcriptional regulator
GWP40_RS04705	COG1124	(ABC) transporter
GWP40_RS04710	COG0747	negative chemotaxis
GWP40_RS04715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWP40_RS04740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWP40_RS04750	COG1199	ATP-dependent helicase activity
GWP40_RS04770	COG0840	transmembrane signaling receptor activity
GWP40_RS04780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWP40_RS04790	COG0840	transmembrane signaling receptor activity
GWP40_RS04800	COG1269	ATP hydrolysis coupled proton transport
GWP40_RS04805	COG1394	ATPase activity, coupled to movement of substances
GWP40_RS04810	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
GWP40_RS04815	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GWP40_RS04825	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
GWP40_RS04835	COG4115	mRNA cleavage
GWP40_RS04845	COG0456	acetyltransferase
GWP40_RS04845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GWP40_RS04885	COG1129	ABC transporter
GWP40_RS04900	COG1132	(ABC) transporter
GWP40_RS04905	COG1132	(ABC) transporter
GWP40_RS04905	COG2375	cellular response to nickel ion
GWP40_RS04955	COG0656	L-ascorbic acid biosynthetic process
GWP40_RS05005	COG2358	TRAP transporter, solute receptor (TAXI family
GWP40_RS05015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWP40_RS05040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWP40_RS05050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWP40_RS05055	COG0772	Belongs to the SEDS family
GWP40_RS05060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWP40_RS05070	COG0275	rRNA processing
GWP40_RS05075	COG2001	Belongs to the MraZ family
GWP40_RS05080	COG3735	TraB family
GWP40_RS05090	COG0564	pseudouridine synthase activity
GWP40_RS05105	COG4166	transmembrane transport
GWP40_RS05140	COG0235	Class ii aldolase
GWP40_RS05145	COG1070	Carbohydrate kinase
GWP40_RS05160	COG3189	MarR family transcriptional regulator
GWP40_RS05170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWP40_RS05180	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GWP40_RS05190	COG0840	transmembrane signaling receptor activity
GWP40_RS05195	COG0318	PFAM AMP-dependent synthetase and ligase
GWP40_RS05200	COG0791	NLP P60 protein
GWP40_RS05215	COG0617	tRNA 3'-terminal CCA addition
GWP40_RS05225	COG2252	PERMEase
GWP40_RS05240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWP40_RS05245	COG0443	Heat shock 70 kDa protein
GWP40_RS05250	COG0484	heat shock protein binding
GWP40_RS05265	COG0170	dolichyl monophosphate biosynthetic process
GWP40_RS05270	COG2239	Acts as a magnesium transporter
GWP40_RS05280	COG3876	Protein conserved in bacteria
GWP40_RS05295	COG0746	molybdenum cofactor guanylyltransferase activity
GWP40_RS05320	COG0739	heme binding
GWP40_RS05330	COG0295	cytidine deaminase activity
GWP40_RS05335	COG1027	Aspartate ammonia-lyase
GWP40_RS05385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWP40_RS05385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWP40_RS05390	COG0564	pseudouridine synthase activity
GWP40_RS05425	COG1129	ABC transporter
GWP40_RS05455	COG3177	Filamentation induced by cAMP protein fic
GWP40_RS05485	COG0427	acetyl-CoA hydrolase
GWP40_RS05490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWP40_RS05495	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWP40_RS05520	COG1454	alcohol dehydrogenase
GWP40_RS05525	COG0802	atpase or kinase
GWP40_RS05535	COG3437	response regulator, receiver
GWP40_RS05535	COG2770	Histidine kinase
GWP40_RS05545	COG1175	transmembrane transport
GWP40_RS05575	COG0488	(ABC) transporter
GWP40_RS05590	COG2703	oxygen carrier activity
GWP40_RS05595	COG1523	belongs to the glycosyl hydrolase 13 family
GWP40_RS05600	COG2182	Extracellular solute-binding protein
GWP40_RS05610	COG1175	transmembrane transport
GWP40_RS05615	COG3833	ABC-type maltose transport systems, permease component
GWP40_RS05620	COG0840	transmembrane signaling receptor activity
GWP40_RS05640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWP40_RS05640	COG0426	domain, Protein
GWP40_RS05645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP40_RS05650	COG0318	PFAM AMP-dependent synthetase and ligase
GWP40_RS05700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWP40_RS05710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWP40_RS05730	COG2304	oxidoreductase activity
GWP40_RS05740	COG0183	Belongs to the thiolase family
GWP40_RS05750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP40_RS05750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP40_RS05755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWP40_RS05765	COG1157	protein secretion by the type III secretion system
GWP40_RS05770	COG1317	bacterial-type flagellum organization
GWP40_RS05780	COG1766	The M ring may be actively involved in energy transduction
GWP40_RS05800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWP40_RS05805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWP40_RS05810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWP40_RS05815	COG0672	)-iron permease
GWP40_RS05820	COG3470	protein probably involved in high-affinity Fe2 transport
GWP40_RS05840	COG1136	(ABC) transporter
GWP40_RS05860	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWP40_RS05875	COG1309	transcriptional regulator
GWP40_RS05880	COG0534	Mate efflux family protein
GWP40_RS05890	COG2226	methyltransferase
GWP40_RS05920	COG0596	Alpha beta hydrolase
GWP40_RS05930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWP40_RS05935	COG0840	transmembrane signaling receptor activity
GWP40_RS05945	COG0514	ATP-dependent DNA helicase (RecQ)
GWP40_RS05970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWP40_RS05975	COG0737	Belongs to the 5'-nucleotidase family
GWP40_RS05985	COG0537	adenosine 5'-monophosphoramidase activity
GWP40_RS05990	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWP40_RS05995	COG2088	sporulation resulting in formation of a cellular spore
GWP40_RS06005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWP40_RS06010	COG0037	tRNA processing
GWP40_RS06020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP40_RS06110	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWP40_RS06115	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWP40_RS06165	COG2971	BadF BadG BcrA BcrD
GWP40_RS06185	COG1573	uracil-dna glycosylase
GWP40_RS06195	COG1482	cell wall glycoprotein biosynthetic process
GWP40_RS06220	COG0495	leucyl-tRNA aminoacylation
GWP40_RS06255	COG0402	S-adenosylhomocysteine deaminase activity
GWP40_RS06260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWP40_RS06260	COG0493	'glutamate synthase
GWP40_RS06280	COG1137	ATPase activity
GWP40_RS06295	COG0708	Exodeoxyribonuclease III
GWP40_RS06315	COG1747	RNA polymerase binding
GWP40_RS06315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWP40_RS06325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWP40_RS06330	COG3956	TIGRFAM MazG family protein
GWP40_RS06340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWP40_RS06345	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GWP40_RS06355	COG0736	holo-[acyl-carrier-protein] synthase activity
GWP40_RS06365	COG0101	tRNA pseudouridine synthase activity
GWP40_RS06370	COG0523	cobalamin synthesis protein
GWP40_RS06375	COG0534	Mate efflux family protein
GWP40_RS06380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWP40_RS06390	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP40_RS06395	COG3876	Protein conserved in bacteria
GWP40_RS06405	COG2885	chlorophyll binding
GWP40_RS06410	COG0741	lytic transglycosylase activity
GWP40_RS06410	COG1388	LysM domain
GWP40_RS06420	COG4115	mRNA cleavage
GWP40_RS06430	COG0166	Belongs to the GPI family
GWP40_RS06440	COG1413	lyase activity
GWP40_RS06455	COG0205	6-phosphofructokinase activity
GWP40_RS06460	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GWP40_RS06480	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GWP40_RS06485	COG1132	(ABC) transporter
GWP40_RS06490	COG4988	ABC transporter
GWP40_RS06495	COG3842	ATPase activity
GWP40_RS06530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWP40_RS06545	COG2885	chlorophyll binding
GWP40_RS06550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWP40_RS06590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWP40_RS06595	COG0358	DNA primase activity
GWP40_RS06600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWP40_RS06620	COG1077	Cell shape determining protein MreB Mrl
GWP40_RS06640	COG0772	Belongs to the SEDS family
GWP40_RS06645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWP40_RS06650	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWP40_RS06655	COG3681	Belongs to the UPF0597 family
GWP40_RS06670	COG1704	LemA family
GWP40_RS06680	COG1132	(ABC) transporter
GWP40_RS06685	COG1132	(ABC) transporter
GWP40_RS06700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWP40_RS06725	COG0497	DNA recombination
GWP40_RS06730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWP40_RS06735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWP40_RS06740	COG0835	chemotaxis
GWP40_RS06750	COG5341	Protein conserved in bacteria
GWP40_RS06755	COG0442	prolyl-tRNA aminoacylation
GWP40_RS06760	COG0424	maF-like protein
GWP40_RS06765	COG0052	Belongs to the universal ribosomal protein uS2 family
GWP40_RS06770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWP40_RS06775	COG0233	cytoplasmic translational termination
GWP40_RS06780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWP40_RS06785	COG0575	Belongs to the CDS family
GWP40_RS06790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWP40_RS06805	COG0750	zinc metalloprotease
GWP40_RS06820	COG1309	transcriptional regulator
GWP40_RS06830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWP40_RS06870	COG0714	Associated with various cellular activities
GWP40_RS06895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWP40_RS06935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWP40_RS06950	COG4213	ABC transporter substrate-binding protein
GWP40_RS06960	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWP40_RS06965	COG1070	Carbohydrate kinase
GWP40_RS06970	COG2115	Belongs to the xylose isomerase family
GWP40_RS06980	COG3330	Domain of unknown function (DUF4912)
GWP40_RS06990	COG0588	phosphoglycerate mutase activity
GWP40_RS06995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWP40_RS07005	COG1131	(ABC) transporter
GWP40_RS07040	COG1131	(ABC) transporter
GWP40_RS07050	COG1086	Polysaccharide biosynthesis protein
GWP40_RS07070	COG1760	l-serine dehydratase
GWP40_RS07075	COG1760	l-serine dehydratase
GWP40_RS07080	COG0149	triose-phosphate isomerase activity
GWP40_RS07115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWP40_RS07135	COG0823	Involved in the tonB-independent uptake of proteins
GWP40_RS07140	COG2204	response regulator
GWP40_RS07145	COG3852	Histidine kinase
GWP40_RS07155	COG3290	protein histidine kinase activity
GWP40_RS07155	COG3829	transcription factor binding
GWP40_RS07165	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GWP40_RS07175	COG1683	Conserved Protein
GWP40_RS07180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP40_RS07185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP40_RS07190	COG1121	(ABC) transporter
GWP40_RS07195	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWP40_RS07200	COG1321	iron dependent repressor
GWP40_RS07205	COG0632	four-way junction helicase activity
GWP40_RS07210	COG1739	Uncharacterized protein family UPF0029
GWP40_RS07215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWP40_RS07220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWP40_RS07230	COG0470	DNA polymerase III
GWP40_RS07250	COG0359	binds to the 23S rRNA
GWP40_RS07255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWP40_RS07260	COG0629	single-stranded DNA binding
GWP40_RS07265	COG0360	Binds together with S18 to 16S ribosomal RNA
GWP40_RS07290	COG2211	Major facilitator Superfamily
GWP40_RS07300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP40_RS07310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP40_RS07320	COG4254	PFAM FecR protein
GWP40_RS07330	COG1234	tRNA 3'-trailer cleavage
GWP40_RS07340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWP40_RS07350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWP40_RS07360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWP40_RS07365	COG2208	phosphoserine phosphatase activity
GWP40_RS07385	COG1914	H( )-stimulated, divalent metal cation uptake system
GWP40_RS07390	COG1414	Transcriptional regulator
GWP40_RS07410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWP40_RS07415	COG0571	ribonuclease III activity
GWP40_RS07420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWP40_RS07425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWP40_RS07440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWP40_RS07470	COG1921	L-seryl-tRNASec selenium transferase activity
GWP40_RS07495	COG0574	Belongs to the PEP-utilizing enzyme family
GWP40_RS07495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWP40_RS07510	COG1230	cation diffusion facilitator family transporter
GWP40_RS07515	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GWP40_RS07535	COG1725	Transcriptional regulator
GWP40_RS07540	COG1131	(ABC) transporter
GWP40_RS07555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWP40_RS07575	COG0455	bacterial-type flagellum organization
GWP40_RS07585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWP40_RS07590	COG0187	DNA topoisomerase II activity
GWP40_RS07615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWP40_RS07620	COG0330	HflC and HflK could
GWP40_RS07625	COG0330	HflC and HflK could
GWP40_RS07680	COG1136	(ABC) transporter
GWP40_RS07685	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWP40_RS07695	COG0552	protein localization to endoplasmic reticulum
GWP40_RS07720	COG1122	ATPase activity
GWP40_RS07725	COG1268	BioY protein
GWP40_RS07735	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWP40_RS07740	COG1876	peptidase activity
GWP40_RS07770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWP40_RS07775	COG0601	transmembrane transport
GWP40_RS07780	COG4608	Belongs to the ABC transporter superfamily
GWP40_RS07790	COG0561	phosphatase activity
GWP40_RS07795	COG0436	Aminotransferase
GWP40_RS07800	COG1522	sequence-specific DNA binding
GWP40_RS07815	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWP40_RS07820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWP40_RS07840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWP40_RS07855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWP40_RS07870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWP40_RS07875	COG2161	toxin-antitoxin pair type II binding
GWP40_RS07890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWP40_RS07895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWP40_RS07900	COG2604	Protein of unknown function DUF115
GWP40_RS07915	COG2186	Transcriptional regulator
GWP40_RS07920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWP40_RS07935	COG1070	Carbohydrate kinase
GWP40_RS07955	COG2388	GCN5-related N-acetyl-transferase
GWP40_RS07965	COG1309	transcriptional regulator
GWP40_RS07970	COG1620	l-lactate permease
GWP40_RS07975	COG4166	transmembrane transport
GWP40_RS07985	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWP40_RS07995	COG0569	domain protein
GWP40_RS08000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWP40_RS08005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWP40_RS08040	COG0456	acetyltransferase
GWP40_RS08060	COG1373	ATPase (AAA superfamily
GWP40_RS08070	COG3142	Participates in the control of copper homeostasis
GWP40_RS08075	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWP40_RS08120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWP40_RS08125	COG0785	Cytochrome C biogenesis protein
GWP40_RS08130	COG0583	DNA-binding transcription factor activity
GWP40_RS08155	COG1222	aaa ATPase
GWP40_RS08195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWP40_RS08215	COG1136	(ABC) transporter
GWP40_RS08220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWP40_RS08235	COG0357	Ribosomal RNA small subunit methyltransferase G
GWP40_RS08240	COG1301	dicarboxylic acid transport
GWP40_RS08255	COG0395	ABC-type sugar transport system, permease component
GWP40_RS08285	COG0228	four-way junction DNA binding
GWP40_RS08290	COG1837	Belongs to the UPF0109 family
GWP40_RS08295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWP40_RS08300	COG0336	Belongs to the RNA methyltransferase TrmD family
GWP40_RS08305	COG0335	large ribosomal subunit rRNA binding
GWP40_RS08315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWP40_RS08445	COG1846	Transcriptional regulator
GWP40_RS08760	COG1115	amino acid carrier protein
GWP40_RS08795	COG0457	Tetratricopeptide repeat
GWP40_RS08800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWP40_RS08805	COG0733	neurotransmitter:sodium symporter activity
GWP40_RS08855	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GWP40_RS08880	COG1509	lysine 2,3-aminomutase activity
GWP40_RS08885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWP40_RS08910	COG1136	(ABC) transporter
GWP40_RS08950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWP40_RS08980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWP40_RS08985	COG1272	protein, Hemolysin III
GWP40_RS08990	COG0254	rRNA binding
GWP40_RS08995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWP40_RS09000	COG1546	Belongs to the CinA family
GWP40_RS09000	COG1058	Belongs to the CinA family
GWP40_RS09010	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWP40_RS09015	COG0776	regulation of translation
GWP40_RS09020	COG0268	Binds directly to 16S ribosomal RNA
GWP40_RS09040	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWP40_RS09050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWP40_RS09060	COG0731	radical SAM domain protein
GWP40_RS09075	COG2201	protein-glutamate methylesterase activity
GWP40_RS09085	COG0835	chemotaxis
GWP40_RS09090	COG0643	Histidine kinase
GWP40_RS09090	COG2198	Histidine kinase
GWP40_RS09100	COG3118	belongs to the thioredoxin family
GWP40_RS09110	COG0617	tRNA 3'-terminal CCA addition
GWP40_RS09115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWP40_RS09140	COG0563	adenylate kinase activity
GWP40_RS09165	COG2357	RelA SpoT domain protein
GWP40_RS09180	COG2375	cellular response to nickel ion
GWP40_RS09180	COG1132	(ABC) transporter
GWP40_RS09185	COG1309	transcriptional regulator
GWP40_RS09195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWP40_RS09220	COG0463	Glycosyl transferase, family 2
GWP40_RS09225	COG0534	Mate efflux family protein
GWP40_RS09230	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GWP40_RS09235	COG0482	sulfurtransferase activity
GWP40_RS09265	COG1196	nuclear chromosome segregation
GWP40_RS09275	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWP40_RS09280	COG0724	RNA recognition motif
GWP40_RS09460	COG1131	(ABC) transporter
GWP40_RS09465	COG1309	transcriptional regulator
GWP40_RS09540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP40_RS09555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWP40_RS09560	COG0142	geranyltranstransferase activity
GWP40_RS09565	COG3579	cysteine-type endopeptidase activity
GWP40_RS09570	COG0475	glutathione-regulated potassium exporter activity
GWP40_RS09580	COG0758	DNA mediated transformation
GWP40_RS09590	COG4974	Belongs to the 'phage' integrase family
GWP40_RS09615	COG2604	Protein of unknown function DUF115
GWP40_RS09635	COG0525	valine-tRNA ligase activity
GWP40_RS09640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWP40_RS09640	COG3608	succinylglutamate desuccinylase aspartoacylase
GWP40_RS09650	COG1362	aminopeptidase activity
GWP40_RS09655	COG0557	exoribonuclease II activity
GWP40_RS09665	COG0534	Mate efflux family protein
GWP40_RS09675	COG1419	protein localization to endoplasmic reticulum
GWP40_RS09685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWP40_RS09690	COG1684	flagellar biosynthetic protein fliR
GWP40_RS09695	COG1987	bacterial-type flagellum assembly
GWP40_RS09700	COG1338	Plays a role in the flagellum-specific transport system
GWP40_RS09710	COG1776	CheC inhibitor of MCP methylation
GWP40_RS09710	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWP40_RS09715	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWP40_RS09720	COG1580	Controls the rotational direction of flagella during chemotaxis
GWP40_RS09730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GWP40_RS09745	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GWP40_RS09755	COG1960	acyl-CoA dehydrogenase activity
GWP40_RS09775	COG0395	ABC-type sugar transport system, permease component
GWP40_RS09780	COG1175	transmembrane transport
GWP40_RS09790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWP40_RS09800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWP40_RS09805	COG0628	permease
GWP40_RS09810	COG0363	glucosamine-6-phosphate deaminase activity
GWP40_RS09815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWP40_RS09825	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GWP40_RS09840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWP40_RS09845	COG1480	7TM receptor with intracellular HD hydrolase
GWP40_RS09860	COG0494	nUDIX hydrolase
GWP40_RS09865	COG1652	LysM domain
GWP40_RS09875	COG0735	belongs to the Fur family
GWP40_RS09885	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GWP40_RS09890	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GWP40_RS09895	COG1924	4 iron, 4 sulfur cluster binding
GWP40_RS09900	COG0786	glutamate:sodium symporter activity
GWP40_RS09905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWP40_RS09910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWP40_RS09915	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWP40_RS09920	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GWP40_RS09925	COG4770	biotin carboxylase activity
GWP40_RS09935	COG0786	glutamate:sodium symporter activity
GWP40_RS09940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWP40_RS09945	COG0840	transmembrane signaling receptor activity
GWP40_RS09975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWP40_RS09980	COG0297	glycogen (starch) synthase activity
GWP40_RS09990	COG1598	PFAM Uncharacterised protein family UPF0150
GWP40_RS09995	COG1205	dead DEAH box helicase
GWP40_RS09995	COG1111	helicase
GWP40_RS10000	COG4115	mRNA cleavage
GWP40_RS10025	COG2337	Toxic component of a toxin-antitoxin (TA) module
GWP40_RS10060	COG0405	Gamma-glutamyltransferase
GWP40_RS10075	COG3608	succinylglutamate desuccinylase aspartoacylase
GWP40_RS10080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWP40_RS10110	COG1846	Transcriptional regulator
GWP40_RS10135	COG1715	Restriction endonuclease
GWP40_RS10160	COG4585	Histidine kinase
GWP40_RS10170	COG0483	inositol monophosphate 1-phosphatase activity
GWP40_RS10185	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWP40_RS10185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWP40_RS10185	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWP40_RS10185	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWP40_RS10195	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWP40_RS10240	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GWP40_RS10255	COG0124	histidyl-tRNA synthetase
GWP40_RS10265	COG0116	Belongs to the methyltransferase superfamily
GWP40_RS10265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWP40_RS10270	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GWP40_RS10290	COG0084	hydrolase, TatD family'
GWP40_RS10325	COG3588	fructose-bisphosphate aldolase
GWP40_RS10340	COG1979	alcohol dehydrogenase
GWP40_RS10355	COG1175	transmembrane transport
GWP40_RS10360	COG0395	ABC-type sugar transport system, permease component
GWP40_RS10395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWP40_RS10395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWP40_RS10400	COG3118	belongs to the thioredoxin family
GWP40_RS10405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GWP40_RS10425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWP40_RS10445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWP40_RS10450	COG0484	heat shock protein binding
GWP40_RS10455	COG0528	UMP kinase activity
GWP40_RS10460	COG1305	Transglutaminase-like
GWP40_RS10475	COG0215	cysteine-tRNA ligase activity
GWP40_RS10480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWP40_RS10485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWP40_RS10500	COG2201	protein-glutamate methylesterase activity
GWP40_RS10535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWP40_RS10560	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWP40_RS10565	COG3041	Addiction module toxin RelE StbE family
GWP40_RS10590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWP40_RS10600	COG0126	phosphoglycerate kinase activity
GWP40_RS10610	COG0813	purine-nucleoside phosphorylase activity
GWP40_RS10625	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWP40_RS10630	COG3639	organic phosphonate transmembrane transporter activity
GWP40_RS10650	COG1187	pseudouridine synthase activity
GWP40_RS10675	COG1129	ABC transporter
GWP40_RS10680	COG1609	Transcriptional regulator
GWP40_RS10690	COG0546	phosphoglycolate phosphatase activity
GWP40_RS10760	COG0756	dUTP diphosphatase activity
GWP40_RS10785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWP40_RS10885	COG1253	flavin adenine dinucleotide binding
GWP40_RS10890	COG0840	transmembrane signaling receptor activity
GWP40_RS10905	COG0756	dUTP diphosphatase activity
GWP40_RS10910	COG1185	polyribonucleotide nucleotidyltransferase activity
GWP40_RS10930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWP40_RS10935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWP40_RS10950	COG0779	Required for maturation of 30S ribosomal subunits
GWP40_RS10970	COG1713	HD superfamily hydrolase involved in NAD metabolism
GWP40_RS10970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWP40_RS10980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWP40_RS10985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWP40_RS10995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWP40_RS11000	COG1047	Peptidyl-prolyl cis-trans
GWP40_RS11015	COG0251	oxidation-reduction process
GWP40_RS11045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWP40_RS11055	COG0556	nucleotide-excision repair
GWP40_RS11065	COG0556	nucleotide-excision repair
GWP40_RS11100	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWP40_RS11120	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GWP40_RS11185	COG1083	cytidylyl-transferase
GWP40_RS11190	COG2089	acid synthase
GWP40_RS11205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GWP40_RS11225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWP40_RS11230	COG1086	Polysaccharide biosynthesis protein
GWP40_RS11235	COG1086	Polysaccharide biosynthesis protein
GWP40_RS11255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWP40_RS11265	COG2076	Multidrug Resistance protein
GWP40_RS11310	COG1373	ATPase (AAA superfamily
GWP40_RS11320	COG0028	Belongs to the TPP enzyme family
GWP40_RS11320	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
GWP40_RS11350	COG1362	aminopeptidase activity
GWP40_RS11355	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWP40_RS11375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWP40_RS11380	COG0017	Asparaginyl-tRNA synthetase
GWP40_RS11400	COG0701	Predicted permease
GWP40_RS11405	COG0116	Belongs to the methyltransferase superfamily
GWP40_RS11410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWP40_RS11415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWP40_RS11420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWP40_RS11430	COG0049	tRNA binding
GWP40_RS11445	COG0085	RNA polymerase activity
GWP40_RS11450	COG0222	ribosome binding
GWP40_RS11455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWP40_RS11465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWP40_RS11470	COG0250	Participates in transcription elongation, termination and antitermination
GWP40_RS11475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWP40_RS11485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWP40_RS11500	COG1438	arginine binding
GWP40_RS11505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWP40_RS11520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWP40_RS11540	COG1254	Belongs to the acylphosphatase family
GWP40_RS11555	COG2217	Heavy metal translocating P-type atpase
GWP40_RS11580	COG1401	restriction endodeoxyribonuclease activity
GWP40_RS11620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWP40_RS11685	COG0616	signal peptide processing
GWP40_RS11690	COG4608	Belongs to the ABC transporter superfamily
GWP40_RS11695	COG0444	Belongs to the ABC transporter superfamily
GWP40_RS11700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWP40_RS11705	COG0601	transmembrane transport
GWP40_RS11715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWP40_RS11720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWP40_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
GWP40_RS11730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWP40_RS11740	COG1647	Serine aminopeptidase, S33
GWP40_RS11795	COG1309	transcriptional regulator
GWP40_RS11810	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWP40_RS11815	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWP40_RS11815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWP40_RS11825	COG0840	transmembrane signaling receptor activity
GWP40_RS11830	COG4443	Transcriptional Coactivator p15 (PC4)
GWP40_RS11835	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWP40_RS11840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP40_RS11860	COG1475	DNA binding
GWP40_RS11865	COG1192	Involved in chromosome partitioning
GWP40_RS11870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWP40_RS11930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWP40_RS11950	COG1132	(ABC) transporter
GWP40_RS11950	COG2375	cellular response to nickel ion
GWP40_RS11955	COG1132	(ABC) transporter
GWP40_RS11975	COG3842	ATPase activity
GWP40_RS11980	COG1840	ABC-type Fe3 transport system, periplasmic component
GWP40_RS11985	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GWP40_RS11995	COG2211	Major facilitator Superfamily
GWP40_RS12005	COG1132	(ABC) transporter
GWP40_RS12020	COG1132	(ABC) transporter
GWP40_RS12030	COG1132	(ABC) transporter
GWP40_RS12035	COG1132	(ABC) transporter
GWP40_RS12055	COG3550	peptidyl-serine autophosphorylation
GWP40_RS12065	COG1162	GTPase activity
GWP40_RS12085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWP40_RS12095	COG0826	peptidase U32
GWP40_RS12110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWP40_RS12120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWP40_RS12125	COG0740	serine-type endopeptidase activity
GWP40_RS12130	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWP40_RS12170	COG0709	Synthesizes selenophosphate from selenide and ATP
GWP40_RS12175	COG3951	Flagellar rod assembly protein muramidase FlgJ
GWP40_RS12185	COG4786	Flagellar basal body rod
GWP40_RS12235	COG1012	belongs to the aldehyde dehydrogenase family
GWP40_RS12240	COG1960	acyl-CoA dehydrogenase activity
GWP40_RS12300	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GWP40_RS12320	COG1191	sigma factor activity
GWP40_RS12335	COG0433	COG0433 Predicted ATPase
GWP40_RS12340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWP40_RS12350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWP40_RS12355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWP40_RS12365	COG0587	DNA-directed DNA polymerase activity
GWP40_RS12380	COG0217	transcriptional regulatory protein
GWP40_RS12395	COG0542	response to heat