locus-tag	class	description
E4N70_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4N70_RS00030	COG1177	transmembrane transport
E4N70_RS00035	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4N70_RS00040	COG3842	ATPase activity
E4N70_RS00050	COG1640	4-alpha-glucanotransferase
E4N70_RS00065	COG0019	diaminopimelate decarboxylase activity
E4N70_RS00070	COG0716	FMN binding
E4N70_RS00085	COG1956	GAF domain-containing protein
E4N70_RS00095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4N70_RS00100	COG1136	(ABC) transporter
E4N70_RS00110	COG0577	efflux transmembrane transporter activity
E4N70_RS00110	COG1136	(ABC) transporter
E4N70_RS00130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N70_RS00145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4N70_RS00145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4N70_RS00155	COG0205	6-phosphofructokinase activity
E4N70_RS00160	COG0516	GMP reductase activity
E4N70_RS00170	COG1028	Short-chain dehydrogenase reductase Sdr
E4N70_RS00175	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E4N70_RS00180	COG2204	response regulator
E4N70_RS00210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N70_RS00215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E4N70_RS00235	COG1686	Belongs to the peptidase S11 family
E4N70_RS00240	COG0739	heme binding
E4N70_RS00250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4N70_RS00255	COG0545	Peptidyl-prolyl cis-trans isomerase
E4N70_RS00285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4N70_RS00305	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4N70_RS00310	COG0592	DNA-directed DNA polymerase activity
E4N70_RS00315	COG2089	acid synthase
E4N70_RS00350	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4N70_RS00390	COG4115	mRNA cleavage
E4N70_RS00420	COG1757	Na H antiporter
E4N70_RS00425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4N70_RS00430	COG2337	Toxic component of a toxin-antitoxin (TA) module
E4N70_RS00460	COG2801	Transposase and inactivated derivatives
E4N70_RS00480	COG3340	Belongs to the peptidase S51 family
E4N70_RS00500	COG2226	methyltransferase
E4N70_RS00510	COG1309	transcriptional regulator
E4N70_RS00540	COG0679	Auxin Efflux Carrier
E4N70_RS00610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4N70_RS00635	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N70_RS00665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E4N70_RS00670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N70_RS00675	COG1028	Short-chain dehydrogenase reductase Sdr
E4N70_RS00685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N70_RS00710	COG2986	histidine ammonia-lyase
E4N70_RS00715	COG3041	Addiction module toxin RelE StbE family
E4N70_RS00740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N70_RS00745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N70_RS00750	COG0204	Acyl-transferase
E4N70_RS00750	COG0318	PFAM AMP-dependent synthetase and ligase
E4N70_RS00790	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
E4N70_RS00800	COG4656	Part of a membrane complex involved in electron transport
E4N70_RS00835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4N70_RS00855	COG1131	(ABC) transporter
E4N70_RS00860	COG0778	Nitroreductase
E4N70_RS00870	COG0822	iron-sulfur transferase activity
E4N70_RS00880	COG0826	peptidase U32
E4N70_RS00910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4N70_RS00915	COG0051	transcription antitermination factor activity, RNA binding
E4N70_RS00920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4N70_RS00925	COG0088	Forms part of the polypeptide exit tunnel
E4N70_RS00930	COG0089	rRNA binding
E4N70_RS00935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4N70_RS00945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4N70_RS00950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4N70_RS00960	COG0255	Belongs to the universal ribosomal protein uL29 family
E4N70_RS00965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4N70_RS00970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4N70_RS00975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4N70_RS00980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4N70_RS00990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4N70_RS00995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4N70_RS01000	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4N70_RS01005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4N70_RS01015	COG0200	Binds to the 23S rRNA
E4N70_RS01025	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4N70_RS01035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4N70_RS01040	COG0202	RNA polymerase activity
E4N70_RS01045	COG0203	ribosomal protein L17
E4N70_RS01060	COG2239	Acts as a magnesium transporter
E4N70_RS01065	COG0170	dolichyl monophosphate biosynthetic process
E4N70_RS01075	COG2252	PERMEase
E4N70_RS01100	COG0511	ligase activity, forming carbon-carbon bonds
E4N70_RS01100	COG5016	pyruvate
E4N70_RS01110	COG0543	2 iron, 2 sulfur cluster binding
E4N70_RS01115	COG1639	'signal transduction protein
E4N70_RS01120	COG1121	(ABC) transporter
E4N70_RS01135	COG1151	hydroxylamine reductase activity
E4N70_RS01145	COG1115	amino acid carrier protein
E4N70_RS01160	COG1609	Transcriptional regulator
E4N70_RS01175	COG0395	ABC-type sugar transport system, permease component
E4N70_RS01185	COG3250	beta-galactosidase activity
E4N70_RS01195	COG0395	ABC-type sugar transport system, permease component
E4N70_RS01200	COG1175	transmembrane transport
E4N70_RS01210	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N70_RS01225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N70_RS01235	COG2011	ABC-type metal ion transport system permease component
E4N70_RS01240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4N70_RS01245	COG0681	Belongs to the peptidase S26 family
E4N70_RS01250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4N70_RS01260	COG1199	ATP-dependent helicase activity
E4N70_RS01290	COG1846	Transcriptional regulator
E4N70_RS01315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4N70_RS01345	COG3842	ATPase activity
E4N70_RS01350	COG0483	inositol monophosphate 1-phosphatase activity
E4N70_RS01360	COG2801	Transposase and inactivated derivatives
E4N70_RS01395	COG4443	Transcriptional Coactivator p15 (PC4)
E4N70_RS01400	COG0840	transmembrane signaling receptor activity
E4N70_RS01420	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4N70_RS01440	COG3437	response regulator, receiver
E4N70_RS01445	COG1671	Belongs to the UPF0178 family
E4N70_RS01450	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4N70_RS01465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4N70_RS01480	COG0513	Belongs to the DEAD box helicase family
E4N70_RS01485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4N70_RS01490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4N70_RS01495	COG1028	Short-chain dehydrogenase reductase Sdr
E4N70_RS01500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4N70_RS01505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N70_RS01510	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N70_RS01525	COG0728	peptidoglycan biosynthetic process
E4N70_RS01555	COG1193	negative regulation of DNA recombination
E4N70_RS01565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4N70_RS01570	COG0733	neurotransmitter:sodium symporter activity
E4N70_RS01585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N70_RS01600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E4N70_RS01615	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4N70_RS01615	COG3608	succinylglutamate desuccinylase aspartoacylase
E4N70_RS01620	COG1640	4-alpha-glucanotransferase
E4N70_RS01625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4N70_RS01685	COG1983	PspC domain protein
E4N70_RS01695	COG1695	Transcriptional regulator
E4N70_RS01710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4N70_RS01720	COG0445	tRNA wobble uridine modification
E4N70_RS01730	COG2255	four-way junction helicase activity
E4N70_RS01735	COG0840	transmembrane signaling receptor activity
E4N70_RS01740	COG1722	exodeoxyribonuclease VII activity
E4N70_RS01745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4N70_RS01750	COG0433	COG0433 Predicted ATPase
E4N70_RS01760	COG1191	sigma factor activity
E4N70_RS01805	COG1414	Transcriptional regulator
E4N70_RS01815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4N70_RS01825	COG0450	alkyl hydroperoxide reductase
E4N70_RS01835	COG0617	tRNA 3'-terminal CCA addition
E4N70_RS01850	COG1027	Aspartate ammonia-lyase
E4N70_RS01855	COG0295	cytidine deaminase activity
E4N70_RS01865	COG0739	heme binding
E4N70_RS01895	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4N70_RS01900	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N70_RS01905	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N70_RS01910	COG1129	ABC transporter
E4N70_RS01915	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N70_RS01920	COG1254	Belongs to the acylphosphatase family
E4N70_RS01930	COG0351	phosphomethylpyrimidine kinase
E4N70_RS01940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4N70_RS01940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4N70_RS01945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N70_RS01960	COG4536	flavin adenine dinucleotide binding
E4N70_RS01970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N70_RS01975	COG0674	pyruvate-flavodoxin oxidoreductase activity
E4N70_RS01975	COG1013	pyruvate-flavodoxin oxidoreductase activity
E4N70_RS01975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4N70_RS01975	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E4N70_RS02045	COG0629	single-stranded DNA binding
E4N70_RS02120	COG0270	DNA (cytosine-5-)-methyltransferase activity
E4N70_RS02295	COG1881	PFAM PEBP family protein
E4N70_RS02310	COG0346	lactoylglutathione lyase activity
E4N70_RS02320	COG0542	response to heat
E4N70_RS02330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N70_RS02335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4N70_RS02340	COG1914	H( )-stimulated, divalent metal cation uptake system
E4N70_RS02345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4N70_RS02350	COG1984	allophanate hydrolase subunit 2
E4N70_RS02360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4N70_RS02365	COG0443	Heat shock 70 kDa protein
E4N70_RS02370	COG0484	heat shock protein binding
E4N70_RS02410	COG0513	Belongs to the DEAD box helicase family
E4N70_RS02420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N70_RS02430	COG0613	PHP domain protein
E4N70_RS02435	COG0670	Belongs to the BI1 family
E4N70_RS02450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4N70_RS02460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N70_RS02495	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
E4N70_RS02495	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4N70_RS02505	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4N70_RS02520	COG3052	prosthetic group binding
E4N70_RS02525	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E4N70_RS02540	COG0793	Belongs to the peptidase S41A family
E4N70_RS02560	COG3876	Protein conserved in bacteria
E4N70_RS02595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4N70_RS02600	COG0706	membrane insertase activity
E4N70_RS02605	COG1847	R3H domain protein
E4N70_RS02615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4N70_RS02620	COG1862	Preprotein translocase
E4N70_RS02625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N70_RS02630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4N70_RS02645	COG1362	aminopeptidase activity
E4N70_RS02650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N70_RS02655	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N70_RS02690	COG4115	mRNA cleavage
E4N70_RS02695	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E4N70_RS02700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4N70_RS02705	COG0457	Tetratricopeptide repeat
E4N70_RS02710	COG0733	neurotransmitter:sodium symporter activity
E4N70_RS02715	COG0180	Tryptophanyl-tRNA synthetase
E4N70_RS02735	COG0406	alpha-ribazole phosphatase activity
E4N70_RS02755	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E4N70_RS02780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4N70_RS02785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4N70_RS02790	COG1570	exodeoxyribonuclease VII activity
E4N70_RS02800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4N70_RS02825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N70_RS02835	COG0534	Mate efflux family protein
E4N70_RS02855	COG1102	Psort location Cytoplasmic, score
E4N70_RS02865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N70_RS02880	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N70_RS02885	COG3845	ABC transporter
E4N70_RS02890	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N70_RS02895	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N70_RS02905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4N70_RS02910	COG1609	Transcriptional regulator
E4N70_RS02915	COG1966	Carbon starvation protein
E4N70_RS02920	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4N70_RS02935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4N70_RS02945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4N70_RS02960	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4N70_RS02965	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4N70_RS02970	COG3845	ABC transporter
E4N70_RS02975	COG1744	ABC transporter substrate-binding protein PnrA-like
E4N70_RS03000	COG0709	Synthesizes selenophosphate from selenide and ATP
E4N70_RS03005	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E4N70_RS03030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4N70_RS03035	COG0419	ATPase involved in DNA repair
E4N70_RS03040	COG0420	3'-5' exonuclease activity
E4N70_RS03045	COG1309	transcriptional regulator
E4N70_RS03050	COG0574	Belongs to the PEP-utilizing enzyme family
E4N70_RS03050	COG3848	Pyruvate phosphate dikinase
E4N70_RS03100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4N70_RS03110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E4N70_RS03115	COG0779	Required for maturation of 30S ribosomal subunits
E4N70_RS03125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E4N70_RS03130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4N70_RS03140	COG0196	riboflavin kinase activity
E4N70_RS03150	COG1185	polyribonucleotide nucleotidyltransferase activity
E4N70_RS03155	COG0756	dUTP diphosphatase activity
E4N70_RS03175	COG0557	exoribonuclease II activity
E4N70_RS03185	COG1362	aminopeptidase activity
E4N70_RS03195	COG3608	succinylglutamate desuccinylase aspartoacylase
E4N70_RS03195	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E4N70_RS03205	COG1247	-acetyltransferase
E4N70_RS03215	COG0698	ribose 5-phosphate isomerase
E4N70_RS03225	COG2375	cellular response to nickel ion
E4N70_RS03225	COG1132	(ABC) transporter
E4N70_RS03230	COG1132	(ABC) transporter
E4N70_RS03285	COG1309	transcriptional regulator
E4N70_RS03295	COG1725	Transcriptional regulator
E4N70_RS03300	COG1131	(ABC) transporter
E4N70_RS03310	COG1373	ATPase (AAA superfamily
E4N70_RS03320	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4N70_RS03335	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E4N70_RS03340	COG1360	Flagellar Motor Protein
E4N70_RS03345	COG1580	Controls the rotational direction of flagella during chemotaxis
E4N70_RS03350	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N70_RS03355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N70_RS03355	COG1776	CheC inhibitor of MCP methylation
E4N70_RS03365	COG1338	Plays a role in the flagellum-specific transport system
E4N70_RS03370	COG1987	bacterial-type flagellum assembly
E4N70_RS03375	COG1684	flagellar biosynthetic protein fliR
E4N70_RS03380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N70_RS03385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4N70_RS03390	COG1419	protein localization to endoplasmic reticulum
E4N70_RS03400	COG1215	transferase activity, transferring glycosyl groups
E4N70_RS03405	COG0534	Mate efflux family protein
E4N70_RS03415	COG0826	peptidase U32
E4N70_RS03425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4N70_RS03435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4N70_RS03450	COG2226	methyltransferase
E4N70_RS03470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N70_RS03475	COG1120	ATPase activity
E4N70_RS03490	COG3951	Flagellar rod assembly protein muramidase FlgJ
E4N70_RS03505	COG1061	Type III restriction enzyme res subunit
E4N70_RS03510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4N70_RS03515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4N70_RS03520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4N70_RS03530	COG1774	PSP1 C-terminal conserved region
E4N70_RS03545	COG0739	heme binding
E4N70_RS03555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4N70_RS03560	COG2911	Protein conserved in bacteria
E4N70_RS03565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N70_RS03575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4N70_RS03585	COG1196	nuclear chromosome segregation
E4N70_RS03585	COG0741	lytic transglycosylase activity
E4N70_RS03585	COG0739	heme binding
E4N70_RS03600	COG2502	aspartate--ammonia ligase
E4N70_RS03610	COG0301	tRNA thio-modification
E4N70_RS03625	COG1879	ABC-type sugar transport system periplasmic component
E4N70_RS03630	COG1129	ABC transporter
E4N70_RS03635	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4N70_RS03645	COG0427	acetyl-CoA hydrolase
E4N70_RS03650	COG1024	Enoyl-CoA hydratase
E4N70_RS03655	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4N70_RS03660	COG1253	flavin adenine dinucleotide binding
E4N70_RS03675	COG3290	protein histidine kinase activity
E4N70_RS03675	COG0840	transmembrane signaling receptor activity
E4N70_RS03690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N70_RS03690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N70_RS03700	COG0481	GTPase activity
E4N70_RS03705	COG0395	ABC-type sugar transport system, permease component
E4N70_RS03710	COG1175	transmembrane transport
E4N70_RS03720	COG0525	valine-tRNA ligase activity
E4N70_RS03740	COG2604	Protein of unknown function DUF115
E4N70_RS03770	COG4974	Belongs to the 'phage' integrase family
E4N70_RS03775	COG0551	DNA topoisomerase type I activity
E4N70_RS03775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4N70_RS03780	COG0758	DNA mediated transformation
E4N70_RS03810	COG0719	Fe-S assembly protein
E4N70_RS03820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4N70_RS03825	COG1692	metallophosphoesterase
E4N70_RS03830	COG3118	belongs to the thioredoxin family
E4N70_RS03840	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4N70_RS03845	COG1288	antiporter activity
E4N70_RS03850	COG0549	Belongs to the carbamate kinase family
E4N70_RS03855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N70_RS03860	COG2235	arginine
E4N70_RS03865	COG0018	arginyl-trna synthetase
E4N70_RS03880	COG2207	Transcriptional regulator
E4N70_RS03880	COG3708	Transcriptional regulator
E4N70_RS03890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4N70_RS03900	COG1175	transmembrane transport
E4N70_RS03905	COG0395	ABC-type sugar transport system, permease component
E4N70_RS03920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4N70_RS03925	COG0672	)-iron permease
E4N70_RS03930	COG3470	protein probably involved in high-affinity Fe2 transport
E4N70_RS03945	COG0577	efflux transmembrane transporter activity
E4N70_RS03945	COG1136	(ABC) transporter
E4N70_RS03950	COG1136	(ABC) transporter
E4N70_RS03955	COG1373	ATPase (AAA superfamily
E4N70_RS04060	COG3842	ATPase activity
E4N70_RS04065	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E4N70_RS04070	COG4988	ABC transporter
E4N70_RS04075	COG1132	(ABC) transporter
E4N70_RS04080	COG0840	transmembrane signaling receptor activity
E4N70_RS04095	COG0546	phosphoglycolate phosphatase activity
E4N70_RS04105	COG1187	pseudouridine synthase activity
E4N70_RS04120	COG3639	organic phosphonate transmembrane transporter activity
E4N70_RS04125	COG3639	organic phosphonate transmembrane transporter activity
E4N70_RS04130	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4N70_RS04145	COG0813	purine-nucleoside phosphorylase activity
E4N70_RS04190	COG0546	phosphoglycolate phosphatase activity
E4N70_RS04195	COG0668	transmembrane transport
E4N70_RS04205	COG0210	DNA helicase
E4N70_RS04215	COG0732	type I restriction modification DNA specificity domain
E4N70_RS04225	COG4974	Belongs to the 'phage' integrase family
E4N70_RS04230	COG3177	Filamentation induced by cAMP protein fic
E4N70_RS04250	COG0732	type I restriction modification DNA specificity domain
E4N70_RS04260	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4N70_RS04300	COG0297	glycogen (starch) synthase activity
E4N70_RS04315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4N70_RS04325	COG0564	pseudouridine synthase activity
E4N70_RS04330	COG0802	atpase or kinase
E4N70_RS04335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N70_RS04340	COG2770	Histidine kinase
E4N70_RS04340	COG3437	response regulator, receiver
E4N70_RS04355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N70_RS04370	COG1760	l-serine dehydratase
E4N70_RS04375	COG1760	l-serine dehydratase
E4N70_RS04380	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4N70_RS04415	COG1647	Serine aminopeptidase, S33
E4N70_RS04420	COG0405	Gamma-glutamyltransferase
E4N70_RS04460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4N70_RS04465	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4N70_RS04480	COG0058	SHG alpha-glucan phosphorylase activity
E4N70_RS04490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4N70_RS04500	COG1040	competence protein
E4N70_RS04510	COG1373	ATPase (AAA superfamily
E4N70_RS04520	COG0028	Belongs to the TPP enzyme family
E4N70_RS04520	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4N70_RS04585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4N70_RS04590	COG1216	Glycosyl transferase, family 2
E4N70_RS04600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N70_RS04625	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4N70_RS04675	COG0577	efflux transmembrane transporter activity
E4N70_RS04675	COG1136	(ABC) transporter
E4N70_RS04680	COG1136	(ABC) transporter
E4N70_RS04695	COG2226	methyltransferase
E4N70_RS04700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4N70_RS04705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4N70_RS04735	COG1413	lyase activity
E4N70_RS04740	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4N70_RS04745	COG0116	Belongs to the methyltransferase superfamily
E4N70_RS04745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4N70_RS04765	COG0343	queuine tRNA-ribosyltransferase activity
E4N70_RS04795	COG2358	TRAP transporter, solute receptor (TAXI family
E4N70_RS04805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N70_RS04830	COG0126	phosphoglycerate kinase activity
E4N70_RS04875	COG2201	protein-glutamate methylesterase activity
E4N70_RS04890	COG0395	ABC-type sugar transport system, permease component
E4N70_RS04895	COG4209	transmembrane transport
E4N70_RS04930	COG0318	PFAM AMP-dependent synthetase and ligase
E4N70_RS04935	COG1283	sodium-dependent phosphate transmembrane transporter activity
E4N70_RS04940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N70_RS04940	COG0574	Belongs to the PEP-utilizing enzyme family
E4N70_RS04965	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4N70_RS04970	COG3041	Addiction module toxin RelE StbE family
E4N70_RS05015	COG1573	uracil-dna glycosylase
E4N70_RS05020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4N70_RS05025	COG1482	cell wall glycoprotein biosynthetic process
E4N70_RS05050	COG1747	RNA polymerase binding
E4N70_RS05050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4N70_RS05070	COG1450	Type ii and iii secretion system protein
E4N70_RS05125	COG3209	COG3209 Rhs family protein
E4N70_RS05150	COG3209	COG3209 Rhs family protein
E4N70_RS05175	COG3209	COG3209 Rhs family protein
E4N70_RS05195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N70_RS05200	COG3956	TIGRFAM MazG family protein
E4N70_RS05210	COG2066	Belongs to the glutaminase family
E4N70_RS05235	COG3142	Participates in the control of copper homeostasis
E4N70_RS05250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4N70_RS05255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4N70_RS05260	COG0427	acetyl-CoA hydrolase
E4N70_RS05295	COG3290	protein histidine kinase activity
E4N70_RS05295	COG3829	transcription factor binding
E4N70_RS05310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N70_RS05315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4N70_RS05330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N70_RS05335	COG2066	Belongs to the glutaminase family
E4N70_RS05340	COG1115	amino acid carrier protein
E4N70_RS05345	COG0840	transmembrane signaling receptor activity
E4N70_RS05350	COG0537	adenosine 5'-monophosphoramidase activity
E4N70_RS05355	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4N70_RS05360	COG2088	sporulation resulting in formation of a cellular spore
E4N70_RS05370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4N70_RS05375	COG0037	tRNA processing
E4N70_RS05380	COG0457	Tetratricopeptide repeat
E4N70_RS05385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N70_RS05390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4N70_RS05400	COG3842	ATPase activity
E4N70_RS05405	COG1840	ABC-type Fe3 transport system, periplasmic component
E4N70_RS05410	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E4N70_RS05415	COG0475	glutathione-regulated potassium exporter activity
E4N70_RS05435	COG1620	l-lactate permease
E4N70_RS05440	COG4166	transmembrane transport
E4N70_RS05450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N70_RS05455	COG2703	oxygen carrier activity
E4N70_RS05485	COG0552	protein localization to endoplasmic reticulum
E4N70_RS05495	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4N70_RS05500	COG1136	(ABC) transporter
E4N70_RS05545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N70_RS05545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4N70_RS05545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N70_RS05560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4N70_RS05565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4N70_RS05570	COG0215	cysteine-tRNA ligase activity
E4N70_RS05585	COG1305	Transglutaminase-like
E4N70_RS05590	COG0528	UMP kinase activity
E4N70_RS05600	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E4N70_RS05620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4N70_RS05640	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E4N70_RS05645	COG3118	belongs to the thioredoxin family
E4N70_RS05650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4N70_RS05650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4N70_RS05675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4N70_RS05680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4N70_RS05685	COG0571	ribonuclease III activity
E4N70_RS05690	COG0840	transmembrane signaling receptor activity
E4N70_RS05695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4N70_RS05710	COG0742	ribosomal rna small subunit methyltransferase
E4N70_RS05725	COG1960	acyl-CoA dehydrogenase activity
E4N70_RS05735	COG1157	protein secretion by the type III secretion system
E4N70_RS05740	COG1317	bacterial-type flagellum organization
E4N70_RS05750	COG1766	The M ring may be actively involved in energy transduction
E4N70_RS05770	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4N70_RS05775	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4N70_RS05780	COG3579	cysteine-type endopeptidase activity
E4N70_RS05795	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4N70_RS05800	COG0166	Belongs to the GPI family
E4N70_RS05805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4N70_RS05815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4N70_RS05820	COG0187	DNA topoisomerase II activity
E4N70_RS05835	COG1067	ATP-dependent peptidase activity
E4N70_RS05845	COG0395	ABC-type sugar transport system, permease component
E4N70_RS05850	COG1175	transmembrane transport
E4N70_RS05865	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E4N70_RS05870	COG2971	BadF BadG BcrA BcrD
E4N70_RS05875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4N70_RS05895	COG2204	response regulator
E4N70_RS05900	COG3852	Histidine kinase
E4N70_RS05910	COG0328	RNA-DNA hybrid ribonuclease activity
E4N70_RS05915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4N70_RS05920	COG0628	permease
E4N70_RS05925	COG0363	glucosamine-6-phosphate deaminase activity
E4N70_RS05930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4N70_RS05950	COG0497	DNA recombination
E4N70_RS05955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4N70_RS05960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N70_RS05965	COG0835	chemotaxis
E4N70_RS05985	COG2211	Major facilitator Superfamily
E4N70_RS05995	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N70_RS06000	COG0154	amidase activity
E4N70_RS06005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4N70_RS06015	COG4254	PFAM FecR protein
E4N70_RS06025	COG1234	tRNA 3'-trailer cleavage
E4N70_RS06050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N70_RS06055	COG1509	lysine 2,3-aminomutase activity
E4N70_RS06065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N70_RS06070	COG1120	ATPase activity
E4N70_RS06085	COG0402	S-adenosylhomocysteine deaminase activity
E4N70_RS06090	COG0493	'glutamate synthase
E4N70_RS06090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4N70_RS06105	COG1137	ATPase activity
E4N70_RS06110	COG2832	Protein of unknown function (DUF454)
E4N70_RS06120	COG0708	Exodeoxyribonuclease III
E4N70_RS06135	COG2208	phosphoserine phosphatase activity
E4N70_RS06140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4N70_RS06145	COG0823	Involved in the tonB-independent uptake of proteins
E4N70_RS06150	COG1490	D-aminoacyl-tRNA deacylase activity
E4N70_RS06155	COG0193	aminoacyl-tRNA hydrolase activity
E4N70_RS06160	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4N70_RS06165	COG1136	(ABC) transporter
E4N70_RS06180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4N70_RS06190	COG2890	protein-(glutamine-N5) methyltransferase activity
E4N70_RS06195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4N70_RS06200	COG0666	response to abiotic stimulus
E4N70_RS06210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4N70_RS06215	COG0785	Cytochrome C biogenesis protein
E4N70_RS06220	COG0583	DNA-binding transcription factor activity
E4N70_RS06235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E4N70_RS06260	COG2801	Transposase and inactivated derivatives
E4N70_RS06270	COG1129	ABC transporter
E4N70_RS06280	COG1132	(ABC) transporter
E4N70_RS06285	COG1132	(ABC) transporter
E4N70_RS06290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4N70_RS06295	COG0426	domain, Protein
E4N70_RS06295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4N70_RS06310	COG2003	Belongs to the UPF0758 family
E4N70_RS06315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4N70_RS06355	COG2801	Transposase and inactivated derivatives
E4N70_RS06370	COG1131	(ABC) transporter
E4N70_RS06390	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N70_RS06395	COG3876	Protein conserved in bacteria
E4N70_RS06405	COG2885	chlorophyll binding
E4N70_RS06410	COG1388	LysM domain
E4N70_RS06410	COG0741	lytic transglycosylase activity
E4N70_RS06440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4N70_RS06460	COG2604	Protein of unknown function DUF115
E4N70_RS06465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N70_RS06475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4N70_RS06495	COG0724	RNA recognition motif
E4N70_RS06500	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4N70_RS06510	COG1196	nuclear chromosome segregation
E4N70_RS06515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N70_RS06520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4N70_RS06535	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4N70_RS06540	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4N70_RS06590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4N70_RS06600	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4N70_RS06610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N70_RS06620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N70_RS06635	COG0504	CTP synthase activity
E4N70_RS06660	COG0482	sulfurtransferase activity
E4N70_RS06685	COG2388	GCN5-related N-acetyl-transferase
E4N70_RS06710	COG1104	cysteine desulfurase activity
E4N70_RS06715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4N70_RS06735	COG0360	Binds together with S18 to 16S ribosomal RNA
E4N70_RS06740	COG0629	single-stranded DNA binding
E4N70_RS06745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4N70_RS06750	COG0359	binds to the 23S rRNA
E4N70_RS06755	COG0305	Participates in initiation and elongation during chromosome replication
E4N70_RS06760	COG1301	dicarboxylic acid transport
E4N70_RS06775	COG0470	DNA polymerase III
E4N70_RS06785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N70_RS06805	COG1122	ATPase activity
E4N70_RS06810	COG1268	BioY protein
E4N70_RS06820	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4N70_RS06855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N70_RS06860	COG0601	transmembrane transport
E4N70_RS06865	COG4608	Belongs to the ABC transporter superfamily
E4N70_RS06875	COG0561	phosphatase activity
E4N70_RS06880	COG0436	Aminotransferase
E4N70_RS06885	COG1522	sequence-specific DNA binding
E4N70_RS06890	COG0534	Mate efflux family protein
E4N70_RS06895	COG0523	cobalamin synthesis protein
E4N70_RS06900	COG0101	tRNA pseudouridine synthase activity
E4N70_RS06910	COG0736	holo-[acyl-carrier-protein] synthase activity
E4N70_RS06920	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4N70_RS06925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4N70_RS06930	COG0519	Catalyzes the synthesis of GMP from XMP
E4N70_RS06980	COG0142	geranyltranstransferase activity
E4N70_RS06985	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E4N70_RS06990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N70_RS06995	COG0840	transmembrane signaling receptor activity
E4N70_RS07015	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4N70_RS07025	COG0569	domain protein
E4N70_RS07030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4N70_RS07040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4N70_RS07070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4N70_RS07075	COG1272	protein, Hemolysin III
E4N70_RS07080	COG0254	rRNA binding
E4N70_RS07085	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4N70_RS07090	COG1546	Belongs to the CinA family
E4N70_RS07090	COG1058	Belongs to the CinA family
E4N70_RS07100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4N70_RS07110	COG0268	Binds directly to 16S ribosomal RNA
E4N70_RS07130	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4N70_RS07135	COG0151	Belongs to the GarS family
E4N70_RS07140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E4N70_RS07150	COG0731	radical SAM domain protein
E4N70_RS07165	COG2201	protein-glutamate methylesterase activity
E4N70_RS07175	COG0835	chemotaxis
E4N70_RS07180	COG0643	Histidine kinase
E4N70_RS07180	COG2198	Histidine kinase
E4N70_RS07190	COG3118	belongs to the thioredoxin family
E4N70_RS07200	COG3833	ABC-type maltose transport systems, permease component
E4N70_RS07205	COG1175	transmembrane transport
E4N70_RS07220	COG2182	Extracellular solute-binding protein
E4N70_RS07225	COG1523	belongs to the glycosyl hydrolase 13 family
E4N70_RS07230	COG0617	tRNA 3'-terminal CCA addition
E4N70_RS07235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E4N70_RS07255	COG1301	dicarboxylic acid transport
E4N70_RS07270	COG1132	(ABC) transporter
E4N70_RS07270	COG2375	cellular response to nickel ion
E4N70_RS07295	COG2357	RelA SpoT domain protein
E4N70_RS07310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4N70_RS07315	COG0563	adenylate kinase activity
E4N70_RS07325	COG0772	Belongs to the SEDS family
E4N70_RS07330	COG0768	penicillin binding
E4N70_RS07345	COG1077	Cell shape determining protein MreB Mrl
E4N70_RS07365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4N70_RS07370	COG0358	DNA primase activity
E4N70_RS07375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4N70_RS07395	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4N70_RS07405	COG1121	(ABC) transporter
E4N70_RS07410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N70_RS07415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N70_RS07420	COG1683	Conserved Protein
E4N70_RS07425	COG0542	response to heat
E4N70_RS07445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4N70_RS07450	COG2885	chlorophyll binding
E4N70_RS07455	COG0149	triose-phosphate isomerase activity
E4N70_RS07470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4N70_RS07505	COG2233	PERMEase
E4N70_RS07510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4N70_RS07525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4N70_RS07535	COG1438	arginine binding
E4N70_RS07540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4N70_RS07550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4N70_RS07560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4N70_RS07585	COG1487	ribonuclease activity
E4N70_RS07590	COG1418	mRNA catabolic process
E4N70_RS07615	COG1475	DNA binding
E4N70_RS07620	COG1192	Involved in chromosome partitioning
E4N70_RS07625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4N70_RS07630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4N70_RS07645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4N70_RS07650	COG3620	sequence-specific DNA binding
E4N70_RS07655	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E4N70_RS07660	COG3421	Type III restriction
E4N70_RS07665	COG0714	Associated with various cellular activities
E4N70_RS07670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4N70_RS07700	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N70_RS07710	COG1309	transcriptional regulator
E4N70_RS07725	COG0750	zinc metalloprotease
E4N70_RS07730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E4N70_RS07735	COG0575	Belongs to the CDS family
E4N70_RS07740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4N70_RS07745	COG0233	cytoplasmic translational termination
E4N70_RS07750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4N70_RS07755	COG0052	Belongs to the universal ribosomal protein uS2 family
E4N70_RS07760	COG0424	maF-like protein
E4N70_RS07765	COG1704	LemA family
E4N70_RS07780	COG3681	Belongs to the UPF0597 family
E4N70_RS07785	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E4N70_RS07790	COG1222	aaa ATPase
E4N70_RS07825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4N70_RS07840	COG4953	penicillin-binding protein 1C
E4N70_RS07880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4N70_RS07885	COG0588	phosphoglycerate mutase activity
E4N70_RS07895	COG3330	Domain of unknown function (DUF4912)
E4N70_RS07920	COG2373	Large extracellular alpha-helical protein
E4N70_RS07935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4N70_RS07945	COG1321	iron dependent repressor
E4N70_RS07950	COG0228	four-way junction DNA binding
E4N70_RS07955	COG1837	Belongs to the UPF0109 family
E4N70_RS07960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4N70_RS07965	COG0336	Belongs to the RNA methyltransferase TrmD family
E4N70_RS07970	COG0335	large ribosomal subunit rRNA binding
E4N70_RS08005	COG0495	leucyl-tRNA aminoacylation
E4N70_RS08020	COG0534	Mate efflux family protein
E4N70_RS08045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4N70_RS08050	COG1480	7TM receptor with intracellular HD hydrolase
E4N70_RS08065	COG0494	nUDIX hydrolase
E4N70_RS08080	COG0735	belongs to the Fur family
E4N70_RS08090	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N70_RS08095	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E4N70_RS08100	COG1924	4 iron, 4 sulfur cluster binding
E4N70_RS08105	COG0786	glutamate:sodium symporter activity
E4N70_RS08110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4N70_RS08115	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4N70_RS08120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4N70_RS08125	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E4N70_RS08130	COG0511	ligase activity, forming carbon-carbon bonds
E4N70_RS08140	COG0786	glutamate:sodium symporter activity
E4N70_RS08145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N70_RS08150	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E4N70_RS08170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4N70_RS08175	COG0205	6-phosphofructokinase activity
E4N70_RS08180	COG0285	dihydrofolate synthase activity
E4N70_RS08185	COG0564	pseudouridine synthase activity
E4N70_RS08225	COG0330	HflC and HflK could
E4N70_RS08230	COG0330	HflC and HflK could
E4N70_RS08240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4N70_RS08285	COG0848	biopolymer transport protein
E4N70_RS08290	COG0811	peptide transport
E4N70_RS08300	COG0455	bacterial-type flagellum organization
E4N70_RS08310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4N70_RS08320	COG0737	Belongs to the 5'-nucleotidase family
E4N70_RS08330	COG3041	Addiction module toxin RelE StbE family
E4N70_RS08340	COG0514	ATP-dependent DNA helicase (RecQ)
E4N70_RS08350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N70_RS08360	COG0322	excinuclease ABC activity
E4N70_RS08375	COG2001	Belongs to the MraZ family
E4N70_RS08380	COG0275	rRNA processing
E4N70_RS08390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4N70_RS08395	COG0772	Belongs to the SEDS family
E4N70_RS08400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4N70_RS08410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4N70_RS08440	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4N70_RS08450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4N70_RS08455	COG0574	Belongs to the PEP-utilizing enzyme family
E4N70_RS08455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4N70_RS08470	COG2304	oxidoreductase activity
E4N70_RS08480	COG0183	Belongs to the thiolase family
E4N70_RS08485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4N70_RS08490	COG0297	glycogen (starch) synthase activity
E4N70_RS08495	COG1022	Amp-dependent synthetase and ligase
E4N70_RS08500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4N70_RS08520	COG3189	MarR family transcriptional regulator
E4N70_RS08530	COG0442	prolyl-tRNA aminoacylation
E4N70_RS08535	COG5341	Protein conserved in bacteria
E4N70_RS08545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4N70_RS08570	COG3116	cell division
E4N70_RS08570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4N70_RS08575	COG0084	hydrolase, TatD family'
E4N70_RS08595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4N70_RS08610	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4N70_RS08615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4N70_RS08620	COG1739	Uncharacterized protein family UPF0029
E4N70_RS08625	COG0632	four-way junction helicase activity
E4N70_RS08685	COG4166	transmembrane transport
E4N70_RS08690	COG0601	transmembrane transport
E4N70_RS08695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4N70_RS08700	COG0444	Belongs to the ABC transporter superfamily
E4N70_RS08705	COG4608	Belongs to the ABC transporter superfamily
E4N70_RS08720	COG0616	signal peptide processing
E4N70_RS08750	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E4N70_RS08760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4N70_RS08780	COG1129	ABC transporter
E4N70_RS08785	COG1609	Transcriptional regulator
E4N70_RS08800	COG0791	NLP P60 protein
E4N70_RS08805	COG0318	PFAM AMP-dependent synthetase and ligase
E4N70_RS08815	COG0577	efflux transmembrane transporter activity
E4N70_RS08815	COG1136	(ABC) transporter
E4N70_RS08825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4N70_RS08835	COG1464	Belongs to the NlpA lipoprotein family
E4N70_RS08850	COG1477	protein flavinylation
E4N70_RS08860	COG3588	fructose-bisphosphate aldolase
E4N70_RS08875	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4N70_RS08890	COG4115	mRNA cleavage
E4N70_RS08895	COG0488	(ABC) transporter
E4N70_RS08910	COG0488	(ABC) transporter
E4N70_RS08940	COG0457	Tetratricopeptide repeat
E4N70_RS08945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4N70_RS08950	COG0733	neurotransmitter:sodium symporter activity
E4N70_RS08955	COG0217	transcriptional regulatory protein
E4N70_RS08965	COG1979	alcohol dehydrogenase
E4N70_RS08970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4N70_RS08975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N70_RS08980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4N70_RS08995	COG0049	tRNA binding
E4N70_RS09010	COG0085	RNA polymerase activity
E4N70_RS09015	COG0222	ribosome binding
E4N70_RS09020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4N70_RS09025	COG0081	regulation of translation
E4N70_RS09030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4N70_RS09035	COG0250	Participates in transcription elongation, termination and antitermination
E4N70_RS09040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N70_RS09050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4N70_RS09070	COG0762	integral membrane protein
E4N70_RS09075	COG0010	Belongs to the arginase family
E4N70_RS09080	COG1914	H( )-stimulated, divalent metal cation uptake system
E4N70_RS09095	COG0587	DNA-directed DNA polymerase activity
E4N70_RS09100	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4N70_RS09110	COG0740	serine-type endopeptidase activity
E4N70_RS09120	COG0681	Belongs to the peptidase S26 family
E4N70_RS09125	COG0840	transmembrane signaling receptor activity
E4N70_RS09160	COG0300	oxidoreductase activity
E4N70_RS09175	COG1288	antiporter activity
E4N70_RS09180	COG2887	Belongs to the helicase family. UvrD subfamily
E4N70_RS09220	COG1960	acyl-CoA dehydrogenase activity
E4N70_RS09225	COG1012	belongs to the aldehyde dehydrogenase family
E4N70_RS09245	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4N70_RS09255	COG0556	nucleotide-excision repair
E4N70_RS09270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4N70_RS09270	COG1713	HD superfamily hydrolase involved in NAD metabolism
E4N70_RS09285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4N70_RS09295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4N70_RS09310	COG0037	tRNA processing
E4N70_RS09325	COG3263	regulation of cellular component size
E4N70_RS09330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4N70_RS09360	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4N70_RS09370	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4N70_RS09375	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4N70_RS09380	COG1394	ATPase activity, coupled to movement of substances
E4N70_RS09385	COG1269	ATP hydrolysis coupled proton transport
E4N70_RS09415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4N70_RS09445	COG0251	oxidation-reduction process
E4N70_RS09460	COG1047	Peptidyl-prolyl cis-trans
E4N70_RS09470	COG4149	molybdate abc transporter
E4N70_RS09475	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4N70_RS09480	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4N70_RS09510	COG1924	4 iron, 4 sulfur cluster binding
E4N70_RS09525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4N70_RS09535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4N70_RS09565	COG2361	Protein of unknown function DUF86
E4N70_RS09580	COG0017	Asparaginyl-tRNA synthetase
E4N70_RS09585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4N70_RS09590	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4N70_RS09605	COG1129	ABC transporter
E4N70_RS09620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4N70_RS09625	COG3706	GGDEF domain
E4N70_RS09625	COG2203	Gaf domain
E4N70_RS09625	COG4251	negative regulation of phosphorylation
E4N70_RS09625	COG5001	Diguanylate cyclase
E4N70_RS09630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N70_RS09635	COG0205	6-phosphofructokinase activity
E4N70_RS09650	COG0124	histidyl-tRNA synthetase
E4N70_RS09660	COG2204	response regulator
E4N70_RS09665	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E4N70_RS09675	COG0840	transmembrane signaling receptor activity
E4N70_RS09680	COG0840	transmembrane signaling receptor activity
E4N70_RS09700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4N70_RS09715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4N70_RS09725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4N70_RS09730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4N70_RS09735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4N70_RS09745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4N70_RS09750	COG2878	Part of a membrane complex involved in electron transport
E4N70_RS09755	COG4657	Part of a membrane complex involved in electron transport
E4N70_RS09760	COG4660	Part of a membrane complex involved in electron transport
E4N70_RS09765	COG4659	FMN binding
E4N70_RS09770	COG4658	electron transport chain
E4N70_RS09775	COG4656	Part of a membrane complex involved in electron transport
E4N70_RS09780	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4N70_RS09795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4N70_RS09800	COG0825	malonyl-CoA metabolic process
E4N70_RS09810	COG0395	ABC-type sugar transport system, permease component
E4N70_RS09815	COG1175	transmembrane transport
E4N70_RS09840	COG0402	S-adenosylhomocysteine deaminase activity
E4N70_RS09845	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E4N70_RS09850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4N70_RS09855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E4N70_RS09865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E4N70_RS09880	COG0039	L-malate dehydrogenase activity
E4N70_RS09885	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4N70_RS09930	COG2910	NAD(P)H-binding
E4N70_RS09935	COG1733	regulation of RNA biosynthetic process
E4N70_RS09955	COG2375	cellular response to nickel ion
E4N70_RS09955	COG1132	(ABC) transporter
E4N70_RS09960	COG1132	(ABC) transporter
E4N70_RS09990	COG1204	response to ionizing radiation
E4N70_RS10020	COG2801	Transposase and inactivated derivatives
E4N70_RS10030	COG1917	Cupin 2, conserved barrel domain protein
E4N70_RS10030	COG4977	sequence-specific DNA binding
E4N70_RS10040	COG2375	cellular response to nickel ion
E4N70_RS10040	COG1132	(ABC) transporter
E4N70_RS10080	COG1132	(ABC) transporter
E4N70_RS10095	COG0714	Associated with various cellular activities
E4N70_RS10105	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E4N70_RS10110	COG1132	(ABC) transporter
E4N70_RS10125	COG1129	ABC transporter
E4N70_RS10130	COG1132	(ABC) transporter
E4N70_RS10140	COG1309	transcriptional regulator
E4N70_RS10155	COG0346	lactoylglutathione lyase activity
E4N70_RS10165	COG0783	Belongs to the Dps family
E4N70_RS10170	COG1881	PFAM PEBP family protein
E4N70_RS10175	COG1715	Restriction endonuclease
E4N70_RS10180	COG1393	Belongs to the ArsC family
E4N70_RS10185	COG1373	ATPase (AAA superfamily
E4N70_RS10215	COG1222	aaa ATPase
E4N70_RS10240	COG1393	Belongs to the ArsC family
E4N70_RS10250	COG1122	ATPase activity
E4N70_RS10265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E4N70_RS10270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4N70_RS10275	COG0840	transmembrane signaling receptor activity
E4N70_RS10290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4N70_RS10300	COG0840	transmembrane signaling receptor activity
E4N70_RS10320	COG0457	Tetratricopeptide repeat
E4N70_RS10325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4N70_RS10350	COG0494	nUDIX hydrolase
E4N70_RS10370	COG0768	penicillin binding
E4N70_RS10375	COG2604	Protein of unknown function DUF115
E4N70_RS10390	COG1193	negative regulation of DNA recombination
E4N70_RS10395	COG1472	Belongs to the glycosyl hydrolase 3 family
E4N70_RS10400	COG0492	ferredoxin-NADP+ reductase activity
E4N70_RS10415	COG0714	Associated with various cellular activities
E4N70_RS10450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E4N70_RS10530	COG0629	single-stranded DNA binding
E4N70_RS10535	COG0281	malic enzyme
E4N70_RS10570	COG0741	lytic transglycosylase activity
E4N70_RS10575	COG1968	undecaprenyl-diphosphatase activity
E4N70_RS10580	COG1674	ftsk spoiiie
E4N70_RS10585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4N70_RS10605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4N70_RS10610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4N70_RS10615	COG0084	hydrolase, TatD family'
E4N70_RS10625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4N70_RS10640	COG0840	transmembrane signaling receptor activity
E4N70_RS10660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N70_RS10685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4N70_RS10695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4N70_RS10700	COG0740	serine-type endopeptidase activity
E4N70_RS10705	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4N70_RS10775	COG2199	diguanylate cyclase activity
E4N70_RS10775	COG2203	Gaf domain
E4N70_RS10780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4N70_RS10795	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E4N70_RS10795	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E4N70_RS10800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N70_RS10805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4N70_RS10830	COG0280	phosphate acetyltransferase
E4N70_RS10835	COG0653	protein targeting
E4N70_RS10850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N70_RS10855	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E4N70_RS10855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E4N70_RS10865	COG1132	(ABC) transporter
E4N70_RS10870	COG1132	(ABC) transporter
E4N70_RS10875	COG1162	GTPase activity
E4N70_RS10915	COG1002	Type II restriction enzyme, methylase subunits
E4N70_RS10960	COG0840	transmembrane signaling receptor activity
E4N70_RS10980	COG2211	Major facilitator Superfamily
E4N70_RS11000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4N70_RS11005	COG1120	ATPase activity
E4N70_RS11020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4N70_RS11025	COG4452	Inner membrane protein CreD
E4N70_RS11040	COG0488	(ABC) transporter
E4N70_RS11075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E4N70_RS11080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4N70_RS11105	COG4555	ABC transporter
E4N70_RS11155	COG1205	dead DEAH box helicase
E4N70_RS11155	COG1111	helicase
E4N70_RS11160	COG2183	response to ionizing radiation
E4N70_RS11170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4N70_RS11175	COG0423	glycine-tRNA ligase activity
E4N70_RS11185	COG0584	glycerophosphoryl diester phosphodiesterase
E4N70_RS11190	COG0840	transmembrane signaling receptor activity
E4N70_RS11225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4N70_RS11250	COG0640	Transcriptional regulator
E4N70_RS11255	COG2217	Heavy metal translocating P-type atpase
E4N70_RS11260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4N70_RS11275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4N70_RS11295	COG0156	8-amino-7-oxononanoate synthase activity
E4N70_RS11300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4N70_RS11370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4N70_RS11375	COG0024	Methionine aminopeptidase
E4N70_RS11380	COG0484	heat shock protein binding
E4N70_RS11415	COG0425	Belongs to the sulfur carrier protein TusA family
E4N70_RS11430	COG3842	ATPase activity
E4N70_RS11435	COG1175	transmembrane transport
E4N70_RS11440	COG0395	ABC-type sugar transport system, permease component
E4N70_RS11445	COG1653	transport
E4N70_RS11470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4N70_RS11470	COG0438	transferase activity, transferring glycosyl groups
E4N70_RS11475	COG0739	heme binding
E4N70_RS11480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4N70_RS11495	COG0701	Predicted permease
E4N70_RS11500	COG0116	Belongs to the methyltransferase superfamily
E4N70_RS11515	COG5001	Diguanylate cyclase
E4N70_RS11520	COG0012	GTP binding
E4N70_RS11540	COG1132	(ABC) transporter
E4N70_RS11545	COG0326	Molecular chaperone. Has ATPase activity
E4N70_RS11550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4N70_RS11560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4N70_RS11590	COG4115	mRNA cleavage
E4N70_RS11595	COG1074	ATP-dependent DNA helicase activity
E4N70_RS11600	COG1132	(ABC) transporter
E4N70_RS11610	COG0237	dephospho-CoA kinase activity
E4N70_RS11620	COG0739	heme binding
E4N70_RS11635	COG1114	Component of the transport system for branched-chain amino acids
E4N70_RS11640	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E4N70_RS11645	COG4750	Nucleotidyl transferase
E4N70_RS11655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities