locus-tag	class	description
GWP43_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWP43_RS00015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWP43_RS00020	COG0156	8-amino-7-oxononanoate synthase activity
GWP43_RS00060	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GWP43_RS00065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP43_RS00070	COG1120	ATPase activity
GWP43_RS00075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWP43_RS00095	COG0326	Molecular chaperone. Has ATPase activity
GWP43_RS00100	COG1162	GTPase activity
GWP43_RS00110	COG1132	(ABC) transporter
GWP43_RS00125	COG2378	regulation of single-species biofilm formation
GWP43_RS00130	COG1002	Type II restriction enzyme, methylase subunits
GWP43_RS00165	COG4115	mRNA cleavage
GWP43_RS00170	COG1132	(ABC) transporter
GWP43_RS00180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWP43_RS00225	COG2183	response to ionizing radiation
GWP43_RS00240	COG2949	membrane
GWP43_RS00275	COG0425	Belongs to the sulfur carrier protein TusA family
GWP43_RS00285	COG0709	Synthesizes selenophosphate from selenide and ATP
GWP43_RS00300	COG0438	transferase activity, transferring glycosyl groups
GWP43_RS00300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWP43_RS00305	COG0488	(ABC) transporter
GWP43_RS00320	COG0840	transmembrane signaling receptor activity
GWP43_RS00325	COG1054	Belongs to the UPF0176 family
GWP43_RS00330	COG0024	Methionine aminopeptidase
GWP43_RS00335	COG0484	heat shock protein binding
GWP43_RS00355	COG0739	heme binding
GWP43_RS00365	COG0534	Mate efflux family protein
GWP43_RS00375	COG1129	ABC transporter
GWP43_RS00500	COG1757	Na H antiporter
GWP43_RS00505	COG5001	Diguanylate cyclase
GWP43_RS00530	COG1074	ATP-dependent DNA helicase activity
GWP43_RS00580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP43_RS00585	COG1917	Cupin 2, conserved barrel domain protein
GWP43_RS00585	COG4977	sequence-specific DNA binding
GWP43_RS00600	COG1129	ABC transporter
GWP43_RS00605	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWP43_RS00615	COG2211	Major facilitator Superfamily
GWP43_RS00625	COG1132	(ABC) transporter
GWP43_RS00630	COG1132	(ABC) transporter
GWP43_RS00635	COG2217	Heavy metal translocating P-type atpase
GWP43_RS00640	COG0640	Transcriptional regulator
GWP43_RS00655	COG2217	Heavy metal translocating P-type atpase
GWP43_RS00705	COG1191	sigma factor activity
GWP43_RS00725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GWP43_RS00760	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GWP43_RS00765	COG0180	Tryptophanyl-tRNA synthetase
GWP43_RS00770	COG0670	Belongs to the BI1 family
GWP43_RS00785	COG2604	Protein of unknown function DUF115
GWP43_RS00790	COG0768	penicillin binding
GWP43_RS00795	COG0681	Belongs to the peptidase S26 family
GWP43_RS01215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWP43_RS01225	COG0613	PHP domain protein
GWP43_RS01250	COG1193	negative regulation of DNA recombination
GWP43_RS01260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GWP43_RS01305	COG0629	single-stranded DNA binding
GWP43_RS01315	COG0281	malic enzyme
GWP43_RS01320	COG0039	L-malate dehydrogenase activity
GWP43_RS01360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GWP43_RS01370	COG0513	Belongs to the DEAD box helicase family
GWP43_RS01380	COG0395	ABC-type sugar transport system, permease component
GWP43_RS01385	COG1175	transmembrane transport
GWP43_RS01395	COG2011	ABC-type metal ion transport system permease component
GWP43_RS01405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP43_RS01420	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GWP43_RS01420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWP43_RS01430	COG0351	phosphomethylpyrimidine kinase
GWP43_RS01445	COG0037	tRNA processing
GWP43_RS01500	COG0840	transmembrane signaling receptor activity
GWP43_RS01525	COG0825	malonyl-CoA metabolic process
GWP43_RS01545	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWP43_RS01550	COG4656	Part of a membrane complex involved in electron transport
GWP43_RS01555	COG4658	electron transport chain
GWP43_RS01560	COG4659	FMN binding
GWP43_RS01565	COG4660	Part of a membrane complex involved in electron transport
GWP43_RS01570	COG4657	Part of a membrane complex involved in electron transport
GWP43_RS01575	COG2878	Part of a membrane complex involved in electron transport
GWP43_RS01580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWP43_RS01585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP43_RS01590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWP43_RS01595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWP43_RS01620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWP43_RS01635	COG0653	protein targeting
GWP43_RS01640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWP43_RS01645	COG0450	alkyl hydroperoxide reductase
GWP43_RS01655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWP43_RS01670	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GWP43_RS01675	COG1671	Belongs to the UPF0178 family
GWP43_RS01680	COG3437	response regulator, receiver
GWP43_RS01685	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWP43_RS01690	COG1115	amino acid carrier protein
GWP43_RS01695	COG5016	pyruvate
GWP43_RS01695	COG0511	ligase activity, forming carbon-carbon bonds
GWP43_RS01700	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP43_RS01705	COG3041	Addiction module toxin RelE StbE family
GWP43_RS01715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GWP43_RS01730	COG1131	(ABC) transporter
GWP43_RS01750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWP43_RS01785	COG4656	Part of a membrane complex involved in electron transport
GWP43_RS01795	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GWP43_RS01800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWP43_RS01825	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWP43_RS01825	COG3608	succinylglutamate desuccinylase aspartoacylase
GWP43_RS01840	COG1121	(ABC) transporter
GWP43_RS01845	COG1639	'signal transduction protein
GWP43_RS01850	COG0543	2 iron, 2 sulfur cluster binding
GWP43_RS01865	COG0733	neurotransmitter:sodium symporter activity
GWP43_RS01870	COG1744	ABC transporter substrate-binding protein PnrA-like
GWP43_RS01880	COG4603	Belongs to the binding-protein-dependent transport system permease family
GWP43_RS01885	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWP43_RS01910	COG4536	flavin adenine dinucleotide binding
GWP43_RS01925	COG0542	response to heat
GWP43_RS01960	COG1012	belongs to the aldehyde dehydrogenase family
GWP43_RS01965	COG1414	Transcriptional regulator
GWP43_RS01975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWP43_RS01985	COG0513	Belongs to the DEAD box helicase family
GWP43_RS01990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWP43_RS01995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWP43_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
GWP43_RS02005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWP43_RS02015	COG1647	Serine aminopeptidase, S33
GWP43_RS02070	COG1309	transcriptional regulator
GWP43_RS02085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWP43_RS02090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWP43_RS02090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWP43_RS02135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GWP43_RS02140	COG0706	membrane insertase activity
GWP43_RS02145	COG1847	R3H domain protein
GWP43_RS02160	COG1862	Preprotein translocase
GWP43_RS02165	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWP43_RS02170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWP43_RS02175	COG1040	competence protein
GWP43_RS02185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWP43_RS02195	COG0058	SHG alpha-glucan phosphorylase activity
GWP43_RS02210	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GWP43_RS02215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP43_RS02225	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GWP43_RS02230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWP43_RS02235	COG0457	Tetratricopeptide repeat
GWP43_RS02240	COG0733	neurotransmitter:sodium symporter activity
GWP43_RS02270	COG1102	Psort location Cytoplasmic, score
GWP43_RS02290	COG0534	Mate efflux family protein
GWP43_RS02305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWP43_RS02345	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWP43_RS02350	COG0740	serine-type endopeptidase activity
GWP43_RS02355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWP43_RS02365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWP43_RS02385	COG0395	ABC-type sugar transport system, permease component
GWP43_RS02390	COG4209	transmembrane transport
GWP43_RS02425	COG1129	ABC transporter
GWP43_RS02475	COG0481	GTPase activity
GWP43_RS02510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWP43_RS02515	COG0549	Belongs to the carbamate kinase family
GWP43_RS02520	COG1288	antiporter activity
GWP43_RS02525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWP43_RS02530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWP43_RS02560	COG1733	regulation of RNA biosynthetic process
GWP43_RS02620	COG1487	ribonuclease activity
GWP43_RS02660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWP43_RS02680	COG1570	exodeoxyribonuclease VII activity
GWP43_RS02695	COG0747	negative chemotaxis
GWP43_RS02700	COG0601	transmembrane transport
GWP43_RS02710	COG4172	Belongs to the ABC transporter superfamily
GWP43_RS02720	COG1132	(ABC) transporter
GWP43_RS02725	COG1132	(ABC) transporter
GWP43_RS02760	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWP43_RS02765	COG1362	aminopeptidase activity
GWP43_RS02800	COG1373	ATPase (AAA superfamily
GWP43_RS02815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GWP43_RS02850	COG1216	Glycosyl transferase, family 2
GWP43_RS02860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWP43_RS02885	COG1393	Belongs to the ArsC family
GWP43_RS02890	COG3328	transposase activity
GWP43_RS02930	COG2361	Protein of unknown function DUF86
GWP43_RS02960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWP43_RS02965	COG1192	Involved in chromosome partitioning
GWP43_RS02970	COG1475	DNA binding
GWP43_RS02980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWP43_RS02985	COG1418	mRNA catabolic process
GWP43_RS03010	COG2161	toxin-antitoxin pair type II binding
GWP43_RS03050	COG3549	Plasmid maintenance system killer
GWP43_RS03065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWP43_RS03070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWP43_RS03075	COG5001	Diguanylate cyclase
GWP43_RS03075	COG2203	Gaf domain
GWP43_RS03075	COG4251	negative regulation of phosphorylation
GWP43_RS03075	COG3706	GGDEF domain
GWP43_RS03080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP43_RS03085	COG0205	6-phosphofructokinase activity
GWP43_RS03090	COG0124	histidyl-tRNA synthetase
GWP43_RS03100	COG2204	response regulator
GWP43_RS03105	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GWP43_RS03115	COG0840	transmembrane signaling receptor activity
GWP43_RS03165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP43_RS03180	COG4786	Flagellar basal body rod
GWP43_RS03190	COG3951	Flagellar rod assembly protein muramidase FlgJ
GWP43_RS03205	COG1120	ATPase activity
GWP43_RS03210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP43_RS03225	COG2226	methyltransferase
GWP43_RS03235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWP43_RS03265	COG0251	oxidation-reduction process
GWP43_RS03280	COG1047	Peptidyl-prolyl cis-trans
GWP43_RS03285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWP43_RS03295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWP43_RS03310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWP43_RS03310	COG1713	HD superfamily hydrolase involved in NAD metabolism
GWP43_RS03330	COG0779	Required for maturation of 30S ribosomal subunits
GWP43_RS03340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWP43_RS03345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWP43_RS03355	COG0196	riboflavin kinase activity
GWP43_RS03370	COG0756	dUTP diphosphatase activity
GWP43_RS03385	COG0840	transmembrane signaling receptor activity
GWP43_RS03390	COG1253	flavin adenine dinucleotide binding
GWP43_RS03405	COG0840	transmembrane signaling receptor activity
GWP43_RS03415	COG0546	phosphoglycolate phosphatase activity
GWP43_RS03425	COG1609	Transcriptional regulator
GWP43_RS03455	COG0762	integral membrane protein
GWP43_RS03470	COG4211	Belongs to the binding-protein-dependent transport system permease family
GWP43_RS03475	COG1129	ABC transporter
GWP43_RS03490	COG1879	ABC-type sugar transport system periplasmic component
GWP43_RS03500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWP43_RS03510	COG0826	peptidase U32
GWP43_RS03530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWP43_RS03535	COG0444	Belongs to the ABC transporter superfamily
GWP43_RS03540	COG4608	Belongs to the ABC transporter superfamily
GWP43_RS03545	COG0616	signal peptide processing
GWP43_RS03585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWP43_RS03595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWP43_RS03610	COG0322	excinuclease ABC activity
GWP43_RS03630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWP43_RS03660	COG4115	mRNA cleavage
GWP43_RS03675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWP43_RS03685	COG0747	negative chemotaxis
GWP43_RS03695	COG0698	ribose 5-phosphate isomerase
GWP43_RS03705	COG2375	cellular response to nickel ion
GWP43_RS03705	COG1132	(ABC) transporter
GWP43_RS03710	COG1132	(ABC) transporter
GWP43_RS03720	COG4115	mRNA cleavage
GWP43_RS03735	COG1131	(ABC) transporter
GWP43_RS03770	COG0456	acetyltransferase
GWP43_RS03770	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GWP43_RS03820	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GWP43_RS03840	COG1360	Flagellar Motor Protein
GWP43_RS03845	COG1580	Controls the rotational direction of flagella during chemotaxis
GWP43_RS03850	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWP43_RS03855	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWP43_RS03855	COG1776	CheC inhibitor of MCP methylation
GWP43_RS03865	COG1338	Plays a role in the flagellum-specific transport system
GWP43_RS03870	COG1987	bacterial-type flagellum assembly
GWP43_RS03875	COG1684	flagellar biosynthetic protein fliR
GWP43_RS03880	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWP43_RS03885	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GWP43_RS03890	COG1419	protein localization to endoplasmic reticulum
GWP43_RS03900	COG0534	Mate efflux family protein
GWP43_RS03910	COG0557	exoribonuclease II activity
GWP43_RS03915	COG1362	aminopeptidase activity
GWP43_RS03925	COG3608	succinylglutamate desuccinylase aspartoacylase
GWP43_RS03925	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWP43_RS03930	COG0525	valine-tRNA ligase activity
GWP43_RS03950	COG2604	Protein of unknown function DUF115
GWP43_RS03975	COG4974	Belongs to the 'phage' integrase family
GWP43_RS03980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWP43_RS03980	COG0551	DNA topoisomerase type I activity
GWP43_RS03985	COG0758	DNA mediated transformation
GWP43_RS03995	COG0475	glutathione-regulated potassium exporter activity
GWP43_RS04000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWP43_RS04005	COG0672	)-iron permease
GWP43_RS04010	COG3470	protein probably involved in high-affinity Fe2 transport
GWP43_RS04025	COG0577	efflux transmembrane transporter activity
GWP43_RS04025	COG1136	(ABC) transporter
GWP43_RS04030	COG1136	(ABC) transporter
GWP43_RS04040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GWP43_RS04045	COG3639	organic phosphonate transmembrane transporter activity
GWP43_RS04065	COG1187	pseudouridine synthase activity
GWP43_RS04070	COG0217	transcriptional regulatory protein
GWP43_RS04075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWP43_RS04085	COG0813	purine-nucleoside phosphorylase activity
GWP43_RS04195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWP43_RS04215	COG1396	sequence-specific DNA binding
GWP43_RS04215	COG3800	Transcriptional regulator
GWP43_RS04325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWP43_RS04340	COG3588	fructose-bisphosphate aldolase
GWP43_RS04355	COG1477	protein flavinylation
GWP43_RS04370	COG1464	Belongs to the NlpA lipoprotein family
GWP43_RS04380	COG0084	hydrolase, TatD family'
GWP43_RS04385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWP43_RS04385	COG3116	cell division
GWP43_RS04415	COG0488	(ABC) transporter
GWP43_RS04420	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GWP43_RS04430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWP43_RS04435	COG0363	glucosamine-6-phosphate deaminase activity
GWP43_RS04440	COG0628	permease
GWP43_RS04445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWP43_RS04450	COG0328	RNA-DNA hybrid ribonuclease activity
GWP43_RS04455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWP43_RS04470	COG0395	ABC-type sugar transport system, permease component
GWP43_RS04490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWP43_RS04515	COG0840	transmembrane signaling receptor activity
GWP43_RS04745	COG1475	DNA binding
GWP43_RS04750	COG1475	DNA binding
GWP43_RS04955	COG1921	L-seryl-tRNASec selenium transferase activity
GWP43_RS04990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWP43_RS04995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWP43_RS05150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWP43_RS05155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWP43_RS05160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWP43_RS05165	COG0571	ribonuclease III activity
GWP43_RS05170	COG0840	transmembrane signaling receptor activity
GWP43_RS05175	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWP43_RS05200	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GWP43_RS05205	COG1960	acyl-CoA dehydrogenase activity
GWP43_RS05210	COG3290	protein histidine kinase activity
GWP43_RS05210	COG3829	transcription factor binding
GWP43_RS05215	COG1024	Enoyl-CoA hydratase
GWP43_RS05220	COG2610	gluconate transmembrane transporter activity
GWP43_RS05230	COG1960	acyl-CoA dehydrogenase activity
GWP43_RS05235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GWP43_RS05245	COG1157	protein secretion by the type III secretion system
GWP43_RS05250	COG1317	bacterial-type flagellum organization
GWP43_RS05260	COG1766	The M ring may be actively involved in energy transduction
GWP43_RS05275	COG1815	bacterial-type flagellum-dependent cell motility
GWP43_RS05280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GWP43_RS05285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GWP43_RS05290	COG3579	cysteine-type endopeptidase activity
GWP43_RS05295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWP43_RS05300	COG0166	Belongs to the GPI family
GWP43_RS05305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWP43_RS05325	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWP43_RS05335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWP43_RS05340	COG0574	Belongs to the PEP-utilizing enzyme family
GWP43_RS05340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWP43_RS05355	COG2304	oxidoreductase activity
GWP43_RS05365	COG0183	Belongs to the thiolase family
GWP43_RS05375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP43_RS05375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP43_RS05380	COG3842	ATPase activity
GWP43_RS05390	COG0343	queuine tRNA-ribosyltransferase activity
GWP43_RS05410	COG2358	TRAP transporter, solute receptor (TAXI family
GWP43_RS05420	COG0708	Exodeoxyribonuclease III
GWP43_RS05430	COG2832	Protein of unknown function (DUF454)
GWP43_RS05435	COG1137	ATPase activity
GWP43_RS05450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWP43_RS05450	COG0493	'glutamate synthase
GWP43_RS05455	COG0402	S-adenosylhomocysteine deaminase activity
GWP43_RS05470	COG1120	ATPase activity
GWP43_RS05475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWP43_RS05540	COG1509	lysine 2,3-aminomutase activity
GWP43_RS05545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWP43_RS05560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GWP43_RS05565	COG0840	transmembrane signaling receptor activity
GWP43_RS05595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWP43_RS05600	COG0617	tRNA 3'-terminal CCA addition
GWP43_RS05605	COG2703	oxygen carrier activity
GWP43_RS05610	COG1523	belongs to the glycosyl hydrolase 13 family
GWP43_RS05615	COG2182	Extracellular solute-binding protein
GWP43_RS05630	COG1175	transmembrane transport
GWP43_RS05635	COG3833	ABC-type maltose transport systems, permease component
GWP43_RS05660	COG3118	belongs to the thioredoxin family
GWP43_RS05670	COG0643	Histidine kinase
GWP43_RS05670	COG2198	Histidine kinase
GWP43_RS05675	COG0835	chemotaxis
GWP43_RS05685	COG2201	protein-glutamate methylesterase activity
GWP43_RS05700	COG0731	radical SAM domain protein
GWP43_RS05720	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWP43_RS05740	COG0268	Binds directly to 16S ribosomal RNA
GWP43_RS05750	COG0776	regulation of translation
GWP43_RS05755	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWP43_RS05765	COG1058	Belongs to the CinA family
GWP43_RS05765	COG1546	Belongs to the CinA family
GWP43_RS05770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWP43_RS05775	COG0254	rRNA binding
GWP43_RS05780	COG1272	protein, Hemolysin III
GWP43_RS05795	COG1131	(ABC) transporter
GWP43_RS05805	COG4585	Histidine kinase
GWP43_RS05820	COG1136	(ABC) transporter
GWP43_RS05880	COG1129	ABC transporter
GWP43_RS05885	COG0346	lactoylglutathione lyase activity
GWP43_RS05895	COG1881	PFAM PEBP family protein
GWP43_RS05900	COG3340	Belongs to the peptidase S51 family
GWP43_RS05930	COG0656	L-ascorbic acid biosynthetic process
GWP43_RS05990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWP43_RS06030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWP43_RS06035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GWP43_RS06040	COG0577	efflux transmembrane transporter activity
GWP43_RS06040	COG1136	(ABC) transporter
GWP43_RS06045	COG0840	transmembrane signaling receptor activity
GWP43_RS06050	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP43_RS06055	COG3876	Protein conserved in bacteria
GWP43_RS06065	COG2885	chlorophyll binding
GWP43_RS06070	COG0741	lytic transglycosylase activity
GWP43_RS06070	COG1388	LysM domain
GWP43_RS06095	COG3142	Participates in the control of copper homeostasis
GWP43_RS06115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWP43_RS06120	COG0714	Associated with various cellular activities
GWP43_RS06135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWP43_RS06145	COG2890	protein-(glutamine-N5) methyltransferase activity
GWP43_RS06155	COG0666	response to abiotic stimulus
GWP43_RS06165	COG4213	ABC transporter substrate-binding protein
GWP43_RS06175	COG1172	Belongs to the binding-protein-dependent transport system permease family
GWP43_RS06180	COG1070	Carbohydrate kinase
GWP43_RS06185	COG2115	Belongs to the xylose isomerase family
GWP43_RS06195	COG3330	Domain of unknown function (DUF4912)
GWP43_RS06205	COG0588	phosphoglycerate mutase activity
GWP43_RS06210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWP43_RS06235	COG2801	Transposase and inactivated derivatives
GWP43_RS06285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWP43_RS06290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GWP43_RS06300	COG0736	holo-[acyl-carrier-protein] synthase activity
GWP43_RS06310	COG0101	tRNA pseudouridine synthase activity
GWP43_RS06315	COG0523	cobalamin synthesis protein
GWP43_RS06320	COG0534	Mate efflux family protein
GWP43_RS06325	COG1522	sequence-specific DNA binding
GWP43_RS06330	COG0436	Aminotransferase
GWP43_RS06335	COG0561	phosphatase activity
GWP43_RS06345	COG4608	Belongs to the ABC transporter superfamily
GWP43_RS06350	COG0601	transmembrane transport
GWP43_RS06355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWP43_RS06400	COG1122	ATPase activity
GWP43_RS06425	COG0552	protein localization to endoplasmic reticulum
GWP43_RS06440	COG1136	(ABC) transporter
GWP43_RS06450	COG0142	geranyltranstransferase activity
GWP43_RS06460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWP43_RS06555	COG1309	transcriptional regulator
GWP43_RS06560	COG1131	(ABC) transporter
GWP43_RS06740	COG1309	transcriptional regulator
GWP43_RS06745	COG1132	(ABC) transporter
GWP43_RS06750	COG1132	(ABC) transporter
GWP43_RS06755	COG1132	(ABC) transporter
GWP43_RS06760	COG1132	(ABC) transporter
GWP43_RS06775	COG4953	penicillin-binding protein 1C
GWP43_RS06790	COG0724	RNA recognition motif
GWP43_RS06800	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWP43_RS06810	COG1196	nuclear chromosome segregation
GWP43_RS06820	COG0733	neurotransmitter:sodium symporter activity
GWP43_RS06825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWP43_RS06830	COG0457	Tetratricopeptide repeat
GWP43_RS06835	COG1704	LemA family
GWP43_RS06845	COG1132	(ABC) transporter
GWP43_RS06850	COG1132	(ABC) transporter
GWP43_RS06865	COG1802	Transcriptional regulator
GWP43_RS06870	COG0632	four-way junction helicase activity
GWP43_RS06875	COG1739	Uncharacterized protein family UPF0029
GWP43_RS06880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWP43_RS06885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWP43_RS06895	COG0470	DNA polymerase III
GWP43_RS06910	COG0305	Participates in initiation and elongation during chromosome replication
GWP43_RS06915	COG0359	binds to the 23S rRNA
GWP43_RS06920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWP43_RS06925	COG0629	single-stranded DNA binding
GWP43_RS06930	COG0360	Binds together with S18 to 16S ribosomal RNA
GWP43_RS06950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWP43_RS06955	COG1104	cysteine desulfurase activity
GWP43_RS06970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWP43_RS06975	COG2208	phosphoserine phosphatase activity
GWP43_RS07015	COG1230	cation diffusion facilitator family transporter
GWP43_RS07025	COG1321	iron dependent repressor
GWP43_RS07030	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWP43_RS07035	COG1121	(ABC) transporter
GWP43_RS07040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP43_RS07045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWP43_RS07050	COG1683	Conserved Protein
GWP43_RS07060	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GWP43_RS07070	COG3829	transcription factor binding
GWP43_RS07070	COG3290	protein histidine kinase activity
GWP43_RS07095	COG3852	Histidine kinase
GWP43_RS07105	COG0823	Involved in the tonB-independent uptake of proteins
GWP43_RS07125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWP43_RS07155	COG0149	triose-phosphate isomerase activity
GWP43_RS07160	COG1760	l-serine dehydratase
GWP43_RS07165	COG1760	l-serine dehydratase
GWP43_RS07185	COG3956	TIGRFAM MazG family protein
GWP43_RS07190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWP43_RS07195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWP43_RS07200	COG2604	Protein of unknown function DUF115
GWP43_RS07225	COG0405	Gamma-glutamyltransferase
GWP43_RS07245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWP43_RS07260	COG1070	Carbohydrate kinase
GWP43_RS07280	COG2388	GCN5-related N-acetyl-transferase
GWP43_RS07305	COG0482	sulfurtransferase activity
GWP43_RS07330	COG0504	CTP synthase activity
GWP43_RS07360	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GWP43_RS07370	COG1487	ribonuclease activity
GWP43_RS07395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWP43_RS07405	COG0569	domain protein
GWP43_RS07410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWP43_RS07430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWP43_RS07435	COG1067	ATP-dependent peptidase activity
GWP43_RS07455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWP43_RS07475	COG3177	Filamentation induced by cAMP protein fic
GWP43_RS07480	COG1129	ABC transporter
GWP43_RS07505	COG1131	(ABC) transporter
GWP43_RS07540	COG1309	transcriptional regulator
GWP43_RS07605	COG0750	zinc metalloprotease
GWP43_RS07610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWP43_RS07615	COG0575	Belongs to the CDS family
GWP43_RS07620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWP43_RS07625	COG0233	cytoplasmic translational termination
GWP43_RS07630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWP43_RS07635	COG0052	Belongs to the universal ribosomal protein uS2 family
GWP43_RS07640	COG0424	maF-like protein
GWP43_RS07650	COG0442	prolyl-tRNA aminoacylation
GWP43_RS07665	COG5341	Protein conserved in bacteria
GWP43_RS07670	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWP43_RS07675	COG0835	chemotaxis
GWP43_RS07685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWP43_RS07690	COG0497	DNA recombination
GWP43_RS07740	COG0427	acetyl-CoA hydrolase
GWP43_RS07745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWP43_RS07750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWP43_RS07775	COG1454	alcohol dehydrogenase
GWP43_RS07790	COG1234	tRNA 3'-trailer cleavage
GWP43_RS07800	COG4254	PFAM FecR protein
GWP43_RS07810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP43_RS07815	COG0154	amidase activity
GWP43_RS07820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP43_RS07830	COG2211	Major facilitator Superfamily
GWP43_RS07865	COG3681	Belongs to the UPF0597 family
GWP43_RS07870	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GWP43_RS07885	COG3597	protein domain associated with
GWP43_RS07895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWP43_RS07915	COG1136	(ABC) transporter
GWP43_RS07920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWP43_RS07925	COG0193	aminoacyl-tRNA hydrolase activity
GWP43_RS07935	COG0357	Ribosomal RNA small subunit methyltransferase G
GWP43_RS07945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWP43_RS07950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWP43_RS07980	COG2226	methyltransferase
GWP43_RS07985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWP43_RS08000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWP43_RS08005	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWP43_RS08010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWP43_RS08025	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWP43_RS08060	COG0519	Catalyzes the synthesis of GMP from XMP
GWP43_RS08085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWP43_RS08095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWP43_RS08100	COG2885	chlorophyll binding
GWP43_RS08185	COG2373	Large extracellular alpha-helical protein
GWP43_RS08195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWP43_RS08200	COG0785	Cytochrome C biogenesis protein
GWP43_RS08205	COG0583	DNA-binding transcription factor activity
GWP43_RS08215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWP43_RS08220	COG2161	toxin-antitoxin pair type II binding
GWP43_RS08235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWP43_RS08245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWP43_RS08245	COG1747	RNA polymerase binding
GWP43_RS08255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWP43_RS08275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWP43_RS08280	COG0297	glycogen (starch) synthase activity
GWP43_RS08290	COG0791	NLP P60 protein
GWP43_RS08295	COG0318	PFAM AMP-dependent synthetase and ligase
GWP43_RS08300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWP43_RS08325	COG4209	transmembrane transport
GWP43_RS08330	COG0395	ABC-type sugar transport system, permease component
GWP43_RS08360	COG0228	four-way junction DNA binding
GWP43_RS08365	COG1837	Belongs to the UPF0109 family
GWP43_RS08370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWP43_RS08375	COG0336	Belongs to the RNA methyltransferase TrmD family
GWP43_RS08380	COG0335	large ribosomal subunit rRNA binding
GWP43_RS08420	COG1773	rubredoxin
GWP43_RS08440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWP43_RS08460	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWP43_RS08470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWP43_RS08490	COG3657	addiction module killer protein
GWP43_RS08495	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWP43_RS08505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWP43_RS08520	COG1132	(ABC) transporter
GWP43_RS08520	COG2375	cellular response to nickel ion
GWP43_RS08530	COG2801	Transposase and inactivated derivatives
GWP43_RS08565	COG2801	Transposase and inactivated derivatives
GWP43_RS08675	COG4988	ABC transporter
GWP43_RS08680	COG1132	(ABC) transporter
GWP43_RS08685	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GWP43_RS08705	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GWP43_RS08715	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GWP43_RS08720	COG0285	dihydrofolate synthase activity
GWP43_RS08725	COG0564	pseudouridine synthase activity
GWP43_RS08770	COG0330	HflC and HflK could
GWP43_RS08775	COG0330	HflC and HflK could
GWP43_RS08795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWP43_RS08875	COG0848	biopolymer transport protein
GWP43_RS08880	COG0811	peptide transport
GWP43_RS08890	COG0455	bacterial-type flagellum organization
GWP43_RS08900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWP43_RS08910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWP43_RS08940	COG0302	gtp cyclohydrolase
GWP43_RS08940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWP43_RS08945	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GWP43_RS08950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWP43_RS08965	COG0564	pseudouridine synthase activity
GWP43_RS08975	COG3735	TraB family
GWP43_RS08985	COG0275	rRNA processing
GWP43_RS08995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWP43_RS09000	COG0772	Belongs to the SEDS family
GWP43_RS09005	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWP43_RS09015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWP43_RS09025	COG1301	dicarboxylic acid transport
GWP43_RS09035	COG1136	(ABC) transporter
GWP43_RS09040	COG0577	efflux transmembrane transporter activity
GWP43_RS09040	COG1136	(ABC) transporter
GWP43_RS09055	COG0534	Mate efflux family protein
GWP43_RS09060	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GWP43_RS09070	COG1309	transcriptional regulator
GWP43_RS09090	COG0395	ABC-type sugar transport system, permease component
GWP43_RS09095	COG1175	transmembrane transport
GWP43_RS09115	COG2971	BadF BadG BcrA BcrD
GWP43_RS09120	COG4886	Leucine-rich repeat (LRR) protein
GWP43_RS09130	COG2233	PERMEase
GWP43_RS09145	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GWP43_RS09160	COG0732	type I restriction modification DNA specificity domain
GWP43_RS09180	COG4974	Belongs to the 'phage' integrase family
GWP43_RS09200	COG0732	type I restriction modification DNA specificity domain
GWP43_RS09365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GWP43_RS09380	COG1653	transport
GWP43_RS09410	COG0116	Belongs to the methyltransferase superfamily
GWP43_RS09410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GWP43_RS09415	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GWP43_RS09420	COG1413	lyase activity
GWP43_RS09435	COG1482	cell wall glycoprotein biosynthetic process
GWP43_RS09440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWP43_RS09445	COG1573	uracil-dna glycosylase
GWP43_RS09465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWP43_RS09470	COG0563	adenylate kinase activity
GWP43_RS09480	COG0772	Belongs to the SEDS family
GWP43_RS09485	COG0768	penicillin binding
GWP43_RS09500	COG1077	Cell shape determining protein MreB Mrl
GWP43_RS09520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWP43_RS09525	COG0358	DNA primase activity
GWP43_RS09530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWP43_RS09550	COG3189	MarR family transcriptional regulator
GWP43_RS09590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWP43_RS09590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWP43_RS09595	COG3118	belongs to the thioredoxin family
GWP43_RS09600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GWP43_RS09620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWP43_RS09640	COG2801	Transposase and inactivated derivatives
GWP43_RS09645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWP43_RS09655	COG0528	UMP kinase activity
GWP43_RS09660	COG1305	Transglutaminase-like
GWP43_RS09675	COG0215	cysteine-tRNA ligase activity
GWP43_RS09680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWP43_RS09700	COG2201	protein-glutamate methylesterase activity
GWP43_RS09740	COG0126	phosphoglycerate kinase activity
GWP43_RS09785	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWP43_RS09805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWP43_RS09805	COG0574	Belongs to the PEP-utilizing enzyme family
GWP43_RS09810	COG1283	sodium-dependent phosphate transmembrane transporter activity
GWP43_RS09815	COG0318	PFAM AMP-dependent synthetase and ligase
GWP43_RS09825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWP43_RS09830	COG0426	domain, Protein
GWP43_RS09830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWP43_RS09860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWP43_RS09865	COG1480	7TM receptor with intracellular HD hydrolase
GWP43_RS09885	COG0494	nUDIX hydrolase
GWP43_RS09890	COG0840	transmembrane signaling receptor activity
GWP43_RS09905	COG0735	belongs to the Fur family
GWP43_RS09920	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GWP43_RS09925	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GWP43_RS09930	COG1924	4 iron, 4 sulfur cluster binding
GWP43_RS09935	COG0786	glutamate:sodium symporter activity
GWP43_RS09940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWP43_RS09945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWP43_RS09955	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GWP43_RS09970	COG0786	glutamate:sodium symporter activity
GWP43_RS09975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWP43_RS09980	COG0840	transmembrane signaling receptor activity
GWP43_RS09995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP43_RS10000	COG0457	Tetratricopeptide repeat
GWP43_RS10005	COG0037	tRNA processing
GWP43_RS10010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWP43_RS10020	COG2088	sporulation resulting in formation of a cellular spore
GWP43_RS10030	COG0537	adenosine 5'-monophosphoramidase activity
GWP43_RS10035	COG1022	Amp-dependent synthetase and ligase
GWP43_RS10045	COG0737	Belongs to the 5'-nucleotidase family
GWP43_RS10065	COG0514	ATP-dependent DNA helicase (RecQ)
GWP43_RS10075	COG0840	transmembrane signaling receptor activity
GWP43_RS10080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWP43_RS10090	COG0596	Alpha beta hydrolase
GWP43_RS10115	COG1309	transcriptional regulator
GWP43_RS10120	COG2375	cellular response to nickel ion
GWP43_RS10120	COG1132	(ABC) transporter
GWP43_RS10125	COG1132	(ABC) transporter
GWP43_RS10130	COG1129	ABC transporter
GWP43_RS10135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GWP43_RS10145	COG2226	methyltransferase
GWP43_RS10160	COG0534	Mate efflux family protein
GWP43_RS10165	COG1309	transcriptional regulator
GWP43_RS10175	COG0488	(ABC) transporter
GWP43_RS10195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWP43_RS10210	COG0049	tRNA binding
GWP43_RS10225	COG0085	RNA polymerase activity
GWP43_RS10230	COG0222	ribosome binding
GWP43_RS10235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWP43_RS10240	COG0081	regulation of translation
GWP43_RS10245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWP43_RS10250	COG0250	Participates in transcription elongation, termination and antitermination
GWP43_RS10255	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GWP43_RS10265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWP43_RS10280	COG1438	arginine binding
GWP43_RS10285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWP43_RS10310	COG0301	tRNA thio-modification
GWP43_RS10320	COG2502	aspartate--ammonia ligase
GWP43_RS10350	COG0739	heme binding
GWP43_RS10365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWP43_RS10375	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWP43_RS10380	COG2911	Protein conserved in bacteria
GWP43_RS10385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWP43_RS10395	COG0739	heme binding
GWP43_RS10410	COG1774	PSP1 C-terminal conserved region
GWP43_RS10430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWP43_RS10435	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWP43_RS10440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWP43_RS10450	COG0427	acetyl-CoA hydrolase
GWP43_RS10455	COG1024	Enoyl-CoA hydratase
GWP43_RS10460	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWP43_RS10465	COG1309	transcriptional regulator
GWP43_RS10470	COG0574	Belongs to the PEP-utilizing enzyme family
GWP43_RS10470	COG3848	Pyruvate phosphate dikinase
GWP43_RS10480	COG0668	transmembrane transport
GWP43_RS10485	COG1840	ABC-type Fe3 transport system, periplasmic component
GWP43_RS10490	COG3842	ATPase activity
GWP43_RS10500	COG1737	Transcriptional regulator
GWP43_RS10510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWP43_RS10515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWP43_RS10520	COG0284	orotidine-5'-phosphate decarboxylase activity
GWP43_RS10525	COG0167	dihydroorotate dehydrogenase activity
GWP43_RS10530	COG0543	2 iron, 2 sulfur cluster binding
GWP43_RS10535	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWP43_RS10540	COG0540	Belongs to the ATCase OTCase family
GWP43_RS10560	COG2375	cellular response to nickel ion
GWP43_RS10560	COG1132	(ABC) transporter
GWP43_RS10565	COG0500	methyltransferase
GWP43_RS10575	COG1132	(ABC) transporter
GWP43_RS10580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWP43_RS10585	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GWP43_RS10605	COG2361	Protein of unknown function DUF86
GWP43_RS10650	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWP43_RS10655	COG4603	Belongs to the binding-protein-dependent transport system permease family
GWP43_RS10660	COG3845	ABC transporter
GWP43_RS10665	COG1744	ABC transporter substrate-binding protein PnrA-like
GWP43_RS10670	COG0840	transmembrane signaling receptor activity
GWP43_RS10675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWP43_RS10680	COG1104	cysteine desulfurase activity
GWP43_RS10695	COG0709	Synthesizes selenophosphate from selenide and ATP
GWP43_RS10700	COG0556	nucleotide-excision repair
GWP43_RS10705	COG0740	serine-type endopeptidase activity
GWP43_RS10730	COG0681	Belongs to the peptidase S26 family
GWP43_RS10735	COG0840	transmembrane signaling receptor activity
GWP43_RS10770	COG0300	oxidoreductase activity
GWP43_RS10780	COG4978	Transcriptional regulator
GWP43_RS10780	COG0789	Transcriptional regulator
GWP43_RS10785	COG1288	antiporter activity
GWP43_RS10795	COG1288	antiporter activity
GWP43_RS10855	COG1960	acyl-CoA dehydrogenase activity
GWP43_RS10860	COG1012	belongs to the aldehyde dehydrogenase family
GWP43_RS10870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWP43_RS10885	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GWP43_RS10910	COG1061	Type III restriction enzyme res subunit
GWP43_RS10915	COG3437	response regulator, receiver
GWP43_RS10915	COG2770	Histidine kinase
GWP43_RS10920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWP43_RS10925	COG0802	atpase or kinase
GWP43_RS10930	COG0564	pseudouridine synthase activity
GWP43_RS10940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWP43_RS10975	COG1966	Carbon starvation protein
GWP43_RS10980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWP43_RS10985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWP43_RS10995	COG1079	Belongs to the binding-protein-dependent transport system permease family
GWP43_RS11005	COG3845	ABC transporter
GWP43_RS11010	COG1744	ABC transporter substrate-binding protein PnrA-like
GWP43_RS11025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWP43_RS11030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWP43_RS11040	COG1570	exodeoxyribonuclease VII activity
GWP43_RS11085	COG0719	Fe-S assembly protein
GWP43_RS11095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWP43_RS11100	COG1692	metallophosphoesterase
GWP43_RS11105	COG3118	belongs to the thioredoxin family
GWP43_RS11115	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GWP43_RS11130	COG1653	transport
GWP43_RS11135	COG1175	transmembrane transport
GWP43_RS11140	COG0395	ABC-type sugar transport system, permease component
GWP43_RS11150	COG0295	cytidine deaminase activity
GWP43_RS11160	COG0739	heme binding
GWP43_RS11185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWP43_RS11200	COG3876	Protein conserved in bacteria
GWP43_RS11205	COG2239	Acts as a magnesium transporter
GWP43_RS11210	COG0170	dolichyl monophosphate biosynthetic process
GWP43_RS11230	COG1132	(ABC) transporter
GWP43_RS11235	COG2375	cellular response to nickel ion
GWP43_RS11235	COG1132	(ABC) transporter
GWP43_RS11245	COG1487	ribonuclease activity
GWP43_RS11255	COG1309	transcriptional regulator
GWP43_RS11260	COG0617	tRNA 3'-terminal CCA addition
GWP43_RS11260	COG0617	tRNA 3'-terminal CCA addition
GWP43_RS11285	COG1205	dead DEAH box helicase
GWP43_RS11285	COG1111	helicase
GWP43_RS11310	COG0484	heat shock protein binding
GWP43_RS11315	COG0443	Heat shock 70 kDa protein
GWP43_RS11320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWP43_RS11360	COG1609	Transcriptional regulator
GWP43_RS11375	COG0395	ABC-type sugar transport system, permease component
GWP43_RS11385	COG3250	beta-galactosidase activity
GWP43_RS11395	COG0395	ABC-type sugar transport system, permease component
GWP43_RS11400	COG1175	transmembrane transport
GWP43_RS11410	COG0840	transmembrane signaling receptor activity
GWP43_RS11415	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWP43_RS11425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWP43_RS11425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWP43_RS11425	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWP43_RS11425	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWP43_RS11445	COG1846	Transcriptional regulator
GWP43_RS11465	COG3842	ATPase activity
GWP43_RS11470	COG0483	inositol monophosphate 1-phosphatase activity
GWP43_RS11485	COG4585	Histidine kinase
GWP43_RS11565	COG3550	peptidyl-serine autophosphorylation
GWP43_RS11575	COG1309	transcriptional regulator
GWP43_RS11590	COG1129	ABC transporter
GWP43_RS11630	COG1846	Transcriptional regulator
GWP43_RS11655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWP43_RS11680	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
GWP43_RS11695	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
GWP43_RS11700	COG1394	ATPase activity, coupled to movement of substances
GWP43_RS11705	COG1269	ATP hydrolysis coupled proton transport
GWP43_RS11720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWP43_RS11730	COG0840	transmembrane signaling receptor activity
GWP43_RS11750	COG1199	ATP-dependent helicase activity
GWP43_RS11760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWP43_RS11770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWP43_RS11785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWP43_RS11825	COG1733	regulation of RNA biosynthetic process
GWP43_RS11870	COG2207	Transcriptional regulator
GWP43_RS11870	COG3708	Transcriptional regulator
GWP43_RS11880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWP43_RS11885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWP43_RS11890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GWP43_RS11895	COG0402	S-adenosylhomocysteine deaminase activity
GWP43_RS11930	COG0732	type I restriction modification DNA specificity domain
GWP43_RS11970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWP43_RS11975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWP43_RS11985	COG0457	Tetratricopeptide repeat
GWP43_RS11990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWP43_RS12040	COG1254	Belongs to the acylphosphatase family
GWP43_RS12060	COG1193	negative regulation of DNA recombination
GWP43_RS12075	COG0433	COG0433 Predicted ATPase
GWP43_RS12080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWP43_RS12085	COG1722	exodeoxyribonuclease VII activity
GWP43_RS12195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWP43_RS12205	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWP43_RS12230	COG0793	Belongs to the peptidase S41A family
GWP43_RS12255	COG3093	addiction module antidote protein HigA
GWP43_RS12270	COG0203	ribosomal protein L17
GWP43_RS12275	COG0202	RNA polymerase activity
GWP43_RS12280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWP43_RS12290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWP43_RS12300	COG0200	Binds to the 23S rRNA
GWP43_RS12310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWP43_RS12325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWP43_RS12335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWP43_RS12340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWP43_RS12345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWP43_RS12350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWP43_RS12355	COG0255	Belongs to the universal ribosomal protein uL29 family
GWP43_RS12365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWP43_RS12380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWP43_RS12385	COG0089	rRNA binding
GWP43_RS12390	COG0088	Forms part of the polypeptide exit tunnel
GWP43_RS12395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWP43_RS12400	COG0051	transcription antitermination factor activity, RNA binding
GWP43_RS12405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWP43_RS12420	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWP43_RS12425	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWP43_RS12430	COG4149	molybdate abc transporter
GWP43_RS12465	COG0741	lytic transglycosylase activity
GWP43_RS12470	COG1968	undecaprenyl-diphosphatase activity
GWP43_RS12475	COG1674	ftsk spoiiie
GWP43_RS12500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWP43_RS12510	COG0084	hydrolase, TatD family'
GWP43_RS12520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWP43_RS12805	COG1846	Transcriptional regulator
GWP43_RS12810	COG0863	Belongs to the N(4) N(6)-methyltransferase family
GWP43_RS12850	COG0629	single-stranded DNA binding
GWP43_RS12915	COG0714	Associated with various cellular activities
GWP43_RS12925	COG0826	peptidase U32
GWP43_RS12935	COG0822	iron-sulfur transferase activity
GWP43_RS12940	COG0564	pseudouridine synthase activity
GWP43_RS12965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWP43_RS12980	COG1695	Transcriptional regulator
GWP43_RS12990	COG1983	PspC domain protein
GWP43_RS13040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP43_RS13040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWP43_RS13040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWP43_RS13050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWP43_RS13055	COG1640	4-alpha-glucanotransferase
GWP43_RS13060	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GWP43_RS13075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWP43_RS13095	COG4443	Transcriptional Coactivator p15 (PC4)
GWP43_RS13170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWP43_RS13180	COG0419	ATPase involved in DNA repair
GWP43_RS13185	COG0420	3'-5' exonuclease activity
GWP43_RS13190	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWP43_RS13205	COG0728	peptidoglycan biosynthetic process
GWP43_RS13215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWP43_RS13230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWP43_RS13245	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GWP43_RS13245	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWP43_RS13250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP43_RS13255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GWP43_RS13275	COG1151	hydroxylamine reductase activity
GWP43_RS13280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWP43_RS13370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWP43_RS13550	COG0280	phosphate acetyltransferase
GWP43_RS13555	COG0492	ferredoxin-NADP+ reductase activity
GWP43_RS13560	COG1472	Belongs to the glycosyl hydrolase 3 family
GWP43_RS13565	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GWP43_RS13575	COG0237	dephospho-CoA kinase activity
GWP43_RS13585	COG0739	heme binding
GWP43_RS13595	COG1114	Component of the transport system for branched-chain amino acids
GWP43_RS13600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GWP43_RS13605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWP43_RS13630	COG1177	transmembrane transport
GWP43_RS13635	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWP43_RS13640	COG3842	ATPase activity
GWP43_RS13645	COG0116	Belongs to the methyltransferase superfamily
GWP43_RS13650	COG0701	Predicted permease
GWP43_RS13670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GWP43_RS13700	COG0012	GTP binding
GWP43_RS13705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWP43_RS13715	COG0071	Belongs to the small heat shock protein (HSP20) family
GWP43_RS13720	COG0019	diaminopimelate decarboxylase activity
GWP43_RS13725	COG0716	FMN binding
GWP43_RS13735	COG1956	GAF domain-containing protein
GWP43_RS13745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWP43_RS13750	COG1136	(ABC) transporter
GWP43_RS13765	COG0561	phosphatase activity
GWP43_RS13780	COG1136	(ABC) transporter
GWP43_RS13780	COG0577	efflux transmembrane transporter activity
GWP43_RS13785	COG1136	(ABC) transporter
GWP43_RS13785	COG0577	efflux transmembrane transporter activity
GWP43_RS13790	COG0840	transmembrane signaling receptor activity
GWP43_RS13795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWP43_RS13800	COG0423	glycine-tRNA ligase activity
GWP43_RS13810	COG0584	glycerophosphoryl diester phosphodiesterase
GWP43_RS13815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWP43_RS13815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWP43_RS13825	COG0205	6-phosphofructokinase activity
GWP43_RS13830	COG0517	IMP dehydrogenase activity
GWP43_RS13830	COG0516	GMP reductase activity
GWP43_RS13840	COG1028	Short-chain dehydrogenase reductase Sdr
GWP43_RS13845	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GWP43_RS13850	COG2204	response regulator
GWP43_RS13890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWP43_RS13915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWP43_RS13920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWP43_RS13940	COG1686	Belongs to the peptidase S11 family
GWP43_RS13945	COG0739	heme binding
GWP43_RS13950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWP43_RS13955	COG0545	Peptidyl-prolyl cis-trans isomerase
GWP43_RS13965	COG2378	regulation of single-species biofilm formation
GWP43_RS13990	COG0464	growth
GWP43_RS14000	COG1309	transcriptional regulator
GWP43_RS14015	COG1129	ABC transporter
GWP43_RS14025	COG1132	(ABC) transporter
GWP43_RS14065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWP43_RS14095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWP43_RS14100	COG0592	DNA-directed DNA polymerase activity
GWP43_RS14105	COG2089	acid synthase
GWP43_RS14120	COG4750	Nucleotidyl transferase
GWP43_RS14130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GWP43_RS14240	COG1129	ABC transporter
GWP43_RS14320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWP43_RS14325	COG1002	Type II restriction enzyme, methylase subunits
GWP43_RS14430	COG2801	Transposase and inactivated derivatives
GWP43_RS14470	COG2801	Transposase and inactivated derivatives
GWP43_RS14530	COG2801	Transposase and inactivated derivatives
GWP43_RS14565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWP43_RS14570	COG0840	transmembrane signaling receptor activity
GWP43_RS14590	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GWP43_RS14730	COG0493	'glutamate synthase
GWP43_RS14730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWP43_RS14800	COG2801	Transposase and inactivated derivatives
GWP43_RS14910	COG1620	l-lactate permease
GWP43_RS14915	COG1620	l-lactate permease
GWP43_RS14920	COG4166	transmembrane transport
GWP43_RS14925	COG4166	transmembrane transport
GWP43_RS14960	COG1131	(ABC) transporter
GWP43_RS14965	COG1131	(ABC) transporter
GWP43_RS15020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWP43_RS15055	COG0681	Belongs to the peptidase S26 family
GWP43_RS15090	COG0840	transmembrane signaling receptor activity
GWP43_RS15095	COG0419	ATPase involved in DNA repair
GWP43_RS15100	COG1114	Component of the transport system for branched-chain amino acids
GWP43_RS15155	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWP43_RS15210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWP43_RS15220	COG1086	Polysaccharide biosynthesis protein
GWP43_RS15245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWP43_RS15275	COG3328	transposase activity
GWP43_RS15290	COG2887	Belongs to the helicase family. UvrD subfamily
GWP43_RS15315	COG0747	negative chemotaxis
GWP43_RS15325	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity