locus-tag	class	description
AVA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AVA_RS00010	COG0592	DNA-directed DNA polymerase activity
AVA_RS00015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVA_RS00020	COG0601	transmembrane transport
AVA_RS00065	COG2267	carboxylic ester hydrolase activity
AVA_RS00080	COG0371	Dehydrogenase
AVA_RS00085	COG0436	Aminotransferase
AVA_RS00090	COG0640	Transcriptional regulator
AVA_RS00105	COG0351	phosphomethylpyrimidine kinase
AVA_RS00105	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AVA_RS00105	COG0352	thiamine-phosphate diphosphorylase activity
AVA_RS00110	COG0463	Glycosyl transferase, family 2
AVA_RS00115	COG0129	dihydroxy-acid dehydratase activity
AVA_RS00130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVA_RS00135	COG0724	RNA recognition motif
AVA_RS00150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AVA_RS00150	COG1754	DNA topoisomerase type I activity
AVA_RS00160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AVA_RS00170	COG1480	7TM receptor with intracellular HD hydrolase
AVA_RS00180	COG0723	plastoquinol--plastocyanin reductase activity
AVA_RS00195	COG2319	Wd-40 repeat
AVA_RS00195	COG4249	Peptidase C14 caspase catalytic subunit p20
AVA_RS00220	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AVA_RS00225	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AVA_RS00230	COG0573	inorganic phosphate transmembrane transporter activity
AVA_RS00235	COG0581	inorganic phosphate transmembrane transporter activity
AVA_RS00240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVA_RS00280	COG3409	Peptidoglycan-binding domain 1 protein
AVA_RS00280	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVA_RS00285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AVA_RS00290	COG0784	Response regulator, receiver
AVA_RS00305	COG0840	transmembrane signaling receptor activity
AVA_RS00310	COG0643	Histidine kinase
AVA_RS00310	COG2198	Histidine kinase
AVA_RS00310	COG0784	Response regulator, receiver
AVA_RS00320	COG2203	Gaf domain
AVA_RS00320	COG3706	GGDEF domain
AVA_RS00320	COG4251	negative regulation of phosphorylation
AVA_RS00320	COG5001	Diguanylate cyclase
AVA_RS00325	COG0745	RESPONSE REGULATOR receiver
AVA_RS00330	COG5002	protein histidine kinase activity
AVA_RS00340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVA_RS00415	COG3852	Histidine kinase
AVA_RS00420	COG0515	serine threonine protein kinase
AVA_RS00440	COG0501	Belongs to the peptidase M48B family
AVA_RS00450	COG0438	transferase activity, transferring glycosyl groups
AVA_RS00450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AVA_RS00465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AVA_RS00470	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AVA_RS00475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AVA_RS00480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AVA_RS00485	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVA_RS00490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVA_RS00515	COG2072	flavoprotein involved in K transport
AVA_RS00540	COG0667	Aldo Keto reductase
AVA_RS00545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVA_RS00560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVA_RS00565	COG0546	phosphoglycolate phosphatase activity
AVA_RS00580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AVA_RS00585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AVA_RS00595	COG0802	atpase or kinase
AVA_RS00600	COG3621	Patatin-like phospholipase
AVA_RS00605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AVA_RS00635	COG3854	ATPases associated with a variety of cellular activities
AVA_RS00640	COG0010	Belongs to the arginase family
AVA_RS00645	COG0724	RNA recognition motif
AVA_RS00655	COG4783	chaperone-mediated protein folding
AVA_RS00670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AVA_RS00675	COG0667	Aldo Keto reductase
AVA_RS00700	COG0346	lactoylglutathione lyase activity
AVA_RS00705	COG0542	response to heat
AVA_RS00715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AVA_RS00725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS00730	COG0793	Belongs to the peptidase S41A family
AVA_RS00740	COG0174	glutamine synthetase
AVA_RS00750	COG2226	methyltransferase
AVA_RS00770	COG0515	serine threonine protein kinase
AVA_RS00770	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS00775	COG1063	alcohol dehydrogenase
AVA_RS00780	COG0306	phosphate transporter
AVA_RS00790	COG0697	spore germination
AVA_RS00800	COG0436	Aminotransferase
AVA_RS00805	COG3118	belongs to the thioredoxin family
AVA_RS00810	COG1842	Phage shock protein A
AVA_RS00815	COG1842	Phage shock protein A
AVA_RS00850	COG0572	uridine kinase
AVA_RS00865	COG2003	Belongs to the UPF0758 family
AVA_RS00885	COG0686	Belongs to the AlaDH PNT family
AVA_RS00890	COG3639	organic phosphonate transmembrane transporter activity
AVA_RS00895	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AVA_RS00915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVA_RS00925	COG0739	heme binding
AVA_RS00935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AVA_RS00945	COG3118	belongs to the thioredoxin family
AVA_RS00950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AVA_RS00965	COG1131	(ABC) transporter
AVA_RS00980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVA_RS00990	COG1492	cobalamin metabolic process
AVA_RS01010	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AVA_RS01025	COG0316	Belongs to the HesB IscA family
AVA_RS01040	COG1090	epimerase
AVA_RS01045	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AVA_RS01075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AVA_RS01095	COG0515	serine threonine protein kinase
AVA_RS01095	COG3266	domain, Protein
AVA_RS01100	COG0515	serine threonine protein kinase
AVA_RS01130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AVA_RS01190	COG0745	RESPONSE REGULATOR receiver
AVA_RS01205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AVA_RS01210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AVA_RS01230	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AVA_RS01235	COG1598	PFAM Uncharacterised protein family UPF0150
AVA_RS01255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AVA_RS01280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVA_RS01280	COG0189	ligase activity
AVA_RS01290	COG1649	PFAM Uncharacterised BCR, COG1649
AVA_RS01300	COG3385	transposase activity
AVA_RS01305	COG1570	exodeoxyribonuclease VII activity
AVA_RS01310	COG1722	exodeoxyribonuclease VII activity
AVA_RS01335	COG1215	transferase activity, transferring glycosyl groups
AVA_RS01340	COG1215	transferase activity, transferring glycosyl groups
AVA_RS01375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVA_RS01380	COG0552	protein localization to endoplasmic reticulum
AVA_RS01385	COG2208	phosphoserine phosphatase activity
AVA_RS01405	COG0237	dephospho-CoA kinase activity
AVA_RS01410	COG0312	modulator of DNA gyrase
AVA_RS01420	COG0523	cobalamin synthesis protein
AVA_RS01470	COG0443	Heat shock 70 kDa protein
AVA_RS01475	COG0826	peptidase U32
AVA_RS01495	COG0793	Belongs to the peptidase S41A family
AVA_RS01500	COG1215	transferase activity, transferring glycosyl groups
AVA_RS01565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVA_RS01580	COG0671	phosphoesterase, PA-phosphatase related
AVA_RS01585	COG0308	aminopeptidase N
AVA_RS01595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVA_RS01625	COG0438	transferase activity, transferring glycosyl groups
AVA_RS01630	COG1132	(ABC) transporter
AVA_RS01645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVA_RS01650	COG0359	binds to the 23S rRNA
AVA_RS01655	COG1372	Participates in initiation and elongation during chromosome replication
AVA_RS01655	COG0305	Participates in initiation and elongation during chromosome replication
AVA_RS01655	COG1372	Participates in initiation and elongation during chromosome replication
AVA_RS01655	COG0305	Participates in initiation and elongation during chromosome replication
AVA_RS01690	COG4242	Belongs to the peptidase S51 family
AVA_RS01695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVA_RS01725	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AVA_RS01775	COG0515	serine threonine protein kinase
AVA_RS01790	COG1187	pseudouridine synthase activity
AVA_RS01795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AVA_RS01810	COG1181	Belongs to the D-alanine--D-alanine ligase family
AVA_RS01820	COG3437	response regulator, receiver
AVA_RS01820	COG3850	Histidine kinase
AVA_RS01820	COG4999	Histidine kinase
AVA_RS01820	COG2205	protein histidine kinase activity
AVA_RS01850	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AVA_RS01850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVA_RS01855	COG3932	Exopolysaccharide synthesis, ExoD
AVA_RS01865	COG4636	protein conserved in cyanobacteria
AVA_RS01870	COG1748	Saccharopine dehydrogenase
AVA_RS01880	COG1459	type II secretion system
AVA_RS01890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AVA_RS01895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVA_RS01900	COG0443	Heat shock 70 kDa protein
AVA_RS01905	COG0484	heat shock protein binding
AVA_RS01915	COG1162	GTPase activity
AVA_RS01920	COG1543	Belongs to the glycosyl hydrolase 57 family
AVA_RS01930	COG0739	heme binding
AVA_RS01935	COG0723	plastoquinol--plastocyanin reductase activity
AVA_RS01945	COG0805	protein transport
AVA_RS01960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AVA_RS02000	COG0824	Thioesterase
AVA_RS02035	COG0330	HflC and HflK could
AVA_RS02045	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVA_RS02050	COG0047	phosphoribosylformylglycinamidine synthase activity
AVA_RS02060	COG0628	permease
AVA_RS02070	COG1316	TRANSCRIPTIONal
AVA_RS02095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVA_RS02105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVA_RS02105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AVA_RS02110	COG1131	(ABC) transporter
AVA_RS02120	COG0393	Putative heavy-metal-binding
AVA_RS02140	COG0719	Fe-S assembly protein
AVA_RS02145	COG0396	ATPase activity
AVA_RS02150	COG0719	Fe-S assembly protein
AVA_RS02155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVA_RS02165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AVA_RS02170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AVA_RS02180	COG0793	Belongs to the peptidase S41A family
AVA_RS02185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AVA_RS02190	COG0515	serine threonine protein kinase
AVA_RS02190	COG2815	serine threonine protein kinase
AVA_RS02195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVA_RS02205	COG1104	cysteine desulfurase activity
AVA_RS02220	COG0481	GTPase activity
AVA_RS02225	COG0574	Belongs to the PEP-utilizing enzyme family
AVA_RS02225	COG3848	Pyruvate phosphate dikinase
AVA_RS02255	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
AVA_RS02290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVA_RS02315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVA_RS02335	COG1175	transmembrane transport
AVA_RS02340	COG1505	serine-type exopeptidase activity
AVA_RS02345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS02395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AVA_RS02405	COG2082	Precorrin-8x methylmutase
AVA_RS02450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVA_RS02475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AVA_RS02490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVA_RS02500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AVA_RS02505	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AVA_RS02510	COG2045	Belongs to the ComB family
AVA_RS02530	COG2205	protein histidine kinase activity
AVA_RS02560	COG0840	transmembrane signaling receptor activity
AVA_RS02575	COG0784	Response regulator, receiver
AVA_RS02585	COG0037	tRNA processing
AVA_RS02595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AVA_RS02615	COG0439	Biotin carboxylase
AVA_RS02630	COG0515	serine threonine protein kinase
AVA_RS02640	COG5001	Diguanylate cyclase
AVA_RS02640	COG3706	GGDEF domain
AVA_RS02640	COG4251	negative regulation of phosphorylation
AVA_RS02640	COG2203	Gaf domain
AVA_RS02650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AVA_RS02665	COG0109	protoheme IX farnesyltransferase activity
AVA_RS02675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVA_RS02680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVA_RS02685	COG1845	cytochrome c oxidase, subunit III
AVA_RS02725	COG2197	response regulator
AVA_RS02735	COG0746	molybdenum cofactor guanylyltransferase activity
AVA_RS02760	COG1331	Highly conserved protein containing a thioredoxin domain
AVA_RS02770	COG0740	serine-type endopeptidase activity
AVA_RS02780	COG0557	exoribonuclease II activity
AVA_RS02785	COG0163	prenyltransferase activity
AVA_RS02800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AVA_RS02805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AVA_RS02820	COG0259	pyridoxamine-phosphate oxidase activity
AVA_RS02825	COG0628	permease
AVA_RS02855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AVA_RS02865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AVA_RS02875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVA_RS02880	COG1049	propionate catabolic process, 2-methylcitrate cycle
AVA_RS02895	COG0443	Heat shock 70 kDa protein
AVA_RS02900	COG4294	response to UV
AVA_RS02910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVA_RS02940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVA_RS02940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AVA_RS02970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVA_RS02975	COG4095	Psort location CytoplasmicMembrane, score
AVA_RS02985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AVA_RS02990	COG0271	Belongs to the BolA IbaG family
AVA_RS02995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AVA_RS03000	COG0521	Mo-molybdopterin cofactor biosynthetic process
AVA_RS03025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVA_RS03035	COG0577	efflux transmembrane transporter activity
AVA_RS03035	COG1136	(ABC) transporter
AVA_RS03050	COG1309	transcriptional regulator
AVA_RS03090	COG0697	spore germination
AVA_RS03100	COG5002	protein histidine kinase activity
AVA_RS03105	COG5002	protein histidine kinase activity
AVA_RS03115	COG0745	RESPONSE REGULATOR receiver
AVA_RS03125	COG0668	transmembrane transport
AVA_RS03180	COG0528	UMP kinase activity
AVA_RS03185	COG0233	cytoplasmic translational termination
AVA_RS03195	COG1228	amidohydrolase
AVA_RS03205	COG1968	undecaprenyl-diphosphatase activity
AVA_RS03215	COG1555	photosystem II stabilization
AVA_RS03220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AVA_RS03235	COG4243	Vitamin k epoxide reductase
AVA_RS03240	COG0434	BtpA family
AVA_RS03245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVA_RS03250	COG0513	Belongs to the DEAD box helicase family
AVA_RS03265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVA_RS03285	COG2205	protein histidine kinase activity
AVA_RS03335	COG2884	Cell division ATP-binding protein ftsE
AVA_RS03345	COG2197	response regulator
AVA_RS03375	COG2119	membrane
AVA_RS03380	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AVA_RS03395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AVA_RS03400	COG0464	growth
AVA_RS03415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AVA_RS03420	COG3228	Belongs to the MtfA family
AVA_RS03440	COG0667	Aldo Keto reductase
AVA_RS03445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVA_RS03455	COG3021	interspecies interaction between organisms
AVA_RS03460	COG0596	Alpha beta hydrolase
AVA_RS03490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AVA_RS03495	COG0088	Forms part of the polypeptide exit tunnel
AVA_RS03500	COG0089	rRNA binding
AVA_RS03505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AVA_RS03510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AVA_RS03515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AVA_RS03520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AVA_RS03525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AVA_RS03530	COG0255	Belongs to the universal ribosomal protein uL29 family
AVA_RS03535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AVA_RS03540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AVA_RS03545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AVA_RS03550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AVA_RS03555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AVA_RS03560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AVA_RS03565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AVA_RS03570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AVA_RS03575	COG0200	Binds to the 23S rRNA
AVA_RS03580	COG0201	protein transport
AVA_RS03585	COG0563	adenylate kinase activity
AVA_RS03590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AVA_RS03595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AVA_RS03600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AVA_RS03605	COG0202	RNA polymerase activity
AVA_RS03610	COG0203	ribosomal protein L17
AVA_RS03615	COG0101	tRNA pseudouridine synthase activity
AVA_RS03620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AVA_RS03625	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AVA_RS03630	COG0254	rRNA binding
AVA_RS03635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AVA_RS03645	COG0488	(ABC) transporter
AVA_RS03650	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AVA_RS03670	COG0438	transferase activity, transferring glycosyl groups
AVA_RS03680	COG1381	Involved in DNA repair and RecF pathway recombination
AVA_RS03685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AVA_RS03715	COG0799	negative regulation of ribosome biogenesis
AVA_RS03720	COG0297	glycogen (starch) synthase activity
AVA_RS03725	COG1126	abc transporter atp-binding protein
AVA_RS03730	COG0765	amino acid transport
AVA_RS03735	COG4597	amino acid ABC transporter
AVA_RS03740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVA_RS03755	COG0602	queuosine metabolic process
AVA_RS03760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVA_RS03780	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS03785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVA_RS03790	COG4279	zinc finger
AVA_RS03795	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS03805	COG0024	Methionine aminopeptidase
AVA_RS03810	COG0673	inositol 2-dehydrogenase activity
AVA_RS03815	COG0633	Ferredoxin
AVA_RS03820	COG2385	sporulation resulting in formation of a cellular spore
AVA_RS03830	COG0783	Belongs to the Dps family
AVA_RS03850	COG1217	gtp-binding protein TYPA
AVA_RS03890	COG0589	response to stress
AVA_RS03895	COG0126	phosphoglycerate kinase activity
AVA_RS03900	COG1051	belongs to the nudix hydrolase family
AVA_RS03910	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVA_RS03935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AVA_RS03940	COG0572	uridine kinase
AVA_RS03945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVA_RS03950	COG0460	homoserine dehydrogenase
AVA_RS03955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVA_RS03970	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AVA_RS03990	COG0745	RESPONSE REGULATOR receiver
AVA_RS03995	COG5002	protein histidine kinase activity
AVA_RS04000	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AVA_RS04005	COG0751	glycine-tRNA ligase activity
AVA_RS04010	COG0598	Magnesium transport protein CorA
AVA_RS04020	COG0571	ribonuclease III activity
AVA_RS04025	COG0673	inositol 2-dehydrogenase activity
AVA_RS04070	COG0583	DNA-binding transcription factor activity
AVA_RS04085	COG1252	NADH dehydrogenase
AVA_RS04105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVA_RS04115	COG0606	chelatase, subunit chli
AVA_RS04120	COG0537	adenosine 5'-monophosphoramidase activity
AVA_RS04130	COG1515	deoxyribonuclease V activity
AVA_RS04180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVA_RS04185	COG0583	DNA-binding transcription factor activity
AVA_RS04190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AVA_RS04190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AVA_RS04195	COG0456	acetyltransferase
AVA_RS04205	COG2203	Gaf domain
AVA_RS04205	COG3706	GGDEF domain
AVA_RS04205	COG4251	negative regulation of phosphorylation
AVA_RS04205	COG5001	Diguanylate cyclase
AVA_RS04215	COG0242	peptide deformylase activity
AVA_RS04220	COG5634	Uncharacterized conserved protein (DUF2278)
AVA_RS04240	COG0424	maF-like protein
AVA_RS04245	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AVA_RS04250	COG0463	Glycosyl transferase, family 2
AVA_RS04250	COG1216	Glycosyl transferase, family 2
AVA_RS04255	COG2244	polysaccharide biosynthetic process
AVA_RS04260	COG1215	transferase activity, transferring glycosyl groups
AVA_RS04265	COG1215	transferase activity, transferring glycosyl groups
AVA_RS04270	COG0438	transferase activity, transferring glycosyl groups
AVA_RS04280	COG1216	Glycosyl transferase, family 2
AVA_RS04280	COG0463	Glycosyl transferase, family 2
AVA_RS04285	COG5039	Polysaccharide pyruvyl transferase
AVA_RS04290	COG2244	polysaccharide biosynthetic process
AVA_RS04295	COG0438	transferase activity, transferring glycosyl groups
AVA_RS04300	COG0463	Glycosyl transferase, family 2
AVA_RS04300	COG1216	Glycosyl transferase, family 2
AVA_RS04305	COG0463	Glycosyl transferase, family 2
AVA_RS04305	COG1216	Glycosyl transferase, family 2
AVA_RS04310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AVA_RS04325	COG0438	transferase activity, transferring glycosyl groups
AVA_RS04330	COG0438	transferase activity, transferring glycosyl groups
AVA_RS04335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVA_RS04340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AVA_RS04365	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AVA_RS04390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVA_RS04395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVA_RS04400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVA_RS04410	COG1233	COG1233 Phytoene dehydrogenase and related
AVA_RS04420	COG3437	response regulator, receiver
AVA_RS04420	COG4999	Histidine kinase
AVA_RS04420	COG2205	protein histidine kinase activity
AVA_RS04420	COG3850	Histidine kinase
AVA_RS04425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVA_RS04430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS04430	COG1116	anion transmembrane transporter activity
AVA_RS04435	COG1116	anion transmembrane transporter activity
AVA_RS04445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AVA_RS04460	COG0481	GTPase activity
AVA_RS04470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AVA_RS04505	COG0668	transmembrane transport
AVA_RS04515	COG1573	uracil-dna glycosylase
AVA_RS04550	COG0390	transport system, permease component
AVA_RS04600	COG0542	response to heat
AVA_RS04605	COG0456	acetyltransferase
AVA_RS04610	COG0019	diaminopimelate decarboxylase activity
AVA_RS04615	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AVA_RS04620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVA_RS04630	COG0484	heat shock protein binding
AVA_RS04640	COG0484	heat shock protein binding
AVA_RS04645	COG0443	Heat shock 70 kDa protein
AVA_RS04650	COG2234	aminopeptidase activity
AVA_RS04660	COG3781	membrane
AVA_RS04670	COG0284	orotidine-5'-phosphate decarboxylase activity
AVA_RS04675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AVA_RS04705	COG0681	Belongs to the peptidase S26 family
AVA_RS04715	COG0837	glucose binding
AVA_RS04730	COG1053	succinate dehydrogenase
AVA_RS04740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVA_RS04765	COG0300	oxidoreductase activity
AVA_RS04785	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AVA_RS04785	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AVA_RS04795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AVA_RS04800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AVA_RS04805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AVA_RS04830	COG0628	permease
AVA_RS04835	COG0284	orotidine-5'-phosphate decarboxylase activity
AVA_RS04835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AVA_RS04840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVA_RS04855	COG0613	PHP domain protein
AVA_RS04865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AVA_RS04870	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AVA_RS04870	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AVA_RS04875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AVA_RS04880	COG2066	Belongs to the glutaminase family
AVA_RS04885	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AVA_RS04915	COG3338	carbonate dehydratase activity
AVA_RS04920	COG0724	RNA recognition motif
AVA_RS04930	COG1040	competence protein
AVA_RS04950	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS04960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVA_RS04970	COG0483	inositol monophosphate 1-phosphatase activity
AVA_RS04975	COG0484	heat shock protein binding
AVA_RS04980	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AVA_RS04985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS05000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVA_RS05005	COG0288	reversible hydration of carbon dioxide
AVA_RS05015	COG2217	Heavy metal translocating P-type atpase
AVA_RS05070	COG1230	cation diffusion facilitator family transporter
AVA_RS05075	COG4251	negative regulation of phosphorylation
AVA_RS05080	COG0784	Response regulator, receiver
AVA_RS05085	COG2202	Pas domain
AVA_RS05085	COG2205	protein histidine kinase activity
AVA_RS05095	COG0107	imidazoleglycerol-phosphate synthase activity
AVA_RS05100	COG2255	four-way junction helicase activity
AVA_RS05120	COG0300	oxidoreductase activity
AVA_RS05150	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AVA_RS05155	COG4251	negative regulation of phosphorylation
AVA_RS05175	COG2205	protein histidine kinase activity
AVA_RS05190	COG1116	anion transmembrane transporter activity
AVA_RS05195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS05195	COG1116	anion transmembrane transporter activity
AVA_RS05200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVA_RS05205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS05210	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AVA_RS05220	COG5001	Diguanylate cyclase
AVA_RS05220	COG4251	negative regulation of phosphorylation
AVA_RS05220	COG3706	GGDEF domain
AVA_RS05220	COG2203	Gaf domain
AVA_RS05240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AVA_RS05260	COG1215	transferase activity, transferring glycosyl groups
AVA_RS05275	COG0438	transferase activity, transferring glycosyl groups
AVA_RS05295	COG0489	protein tyrosine kinase activity
AVA_RS05300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVA_RS05335	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AVA_RS05340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AVA_RS05340	COG0519	Catalyzes the synthesis of GMP from XMP
AVA_RS05355	COG0730	response to heat
AVA_RS05370	COG1473	amidohydrolase
AVA_RS05380	COG1032	radical SAM domain protein
AVA_RS05390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVA_RS05395	COG1733	regulation of RNA biosynthetic process
AVA_RS05415	COG0569	domain protein
AVA_RS05425	COG0025	NhaP-type Na H and K H
AVA_RS05455	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AVA_RS05470	COG2226	methyltransferase
AVA_RS05480	COG0674	pyruvate-flavodoxin oxidoreductase activity
AVA_RS05480	COG1013	pyruvate-flavodoxin oxidoreductase activity
AVA_RS05480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AVA_RS05480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AVA_RS05520	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AVA_RS05530	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AVA_RS05535	COG3977	Valine--pyruvate aminotransferase
AVA_RS05540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AVA_RS05565	COG2274	protein secretion by the type I secretion system
AVA_RS05595	COG4245	von Willebrand factor, type A
AVA_RS05610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVA_RS05615	COG0579	oxidoreductase
AVA_RS05620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVA_RS05650	COG0460	homoserine dehydrogenase
AVA_RS05660	COG0489	protein tyrosine kinase activity
AVA_RS05670	COG1132	(ABC) transporter
AVA_RS05675	COG1215	transferase activity, transferring glycosyl groups
AVA_RS05690	COG0438	transferase activity, transferring glycosyl groups
AVA_RS05710	COG0640	Transcriptional regulator
AVA_RS05720	COG2274	protein secretion by the type I secretion system
AVA_RS05770	COG0662	Cupin 2, conserved barrel domain protein
AVA_RS05770	COG2207	Transcriptional regulator
AVA_RS05815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVA_RS05825	COG5002	protein histidine kinase activity
AVA_RS05845	COG2815	serine threonine protein kinase
AVA_RS05845	COG0515	serine threonine protein kinase
AVA_RS05860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AVA_RS05895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVA_RS05900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AVA_RS05905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVA_RS05910	COG0735	belongs to the Fur family
AVA_RS05925	COG2205	protein histidine kinase activity
AVA_RS05925	COG2202	Pas domain
AVA_RS05945	COG2239	Acts as a magnesium transporter
AVA_RS05955	COG0540	Belongs to the ATCase OTCase family
AVA_RS05960	COG2205	protein histidine kinase activity
AVA_RS05970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AVA_RS05980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVA_RS06010	COG0297	glycogen (starch) synthase activity
AVA_RS06020	COG2274	protein secretion by the type I secretion system
AVA_RS06025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVA_RS06035	COG2205	protein histidine kinase activity
AVA_RS06040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AVA_RS06050	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AVA_RS06055	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AVA_RS06060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVA_RS06065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AVA_RS06070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVA_RS06080	COG2010	Cytochrome c
AVA_RS06085	COG0673	inositol 2-dehydrogenase activity
AVA_RS06100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AVA_RS06110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AVA_RS06140	COG1285	pathogenesis
AVA_RS06145	COG0431	NADPH-dependent FMN reductase
AVA_RS06165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVA_RS06185	COG0167	dihydroorotate dehydrogenase activity
AVA_RS06200	COG1695	Transcriptional regulator
AVA_RS06205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVA_RS06215	COG0217	transcriptional regulatory protein
AVA_RS06245	COG1136	(ABC) transporter
AVA_RS06245	COG0577	efflux transmembrane transporter activity
AVA_RS06255	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AVA_RS06260	COG2211	Major facilitator Superfamily
AVA_RS06265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVA_RS06270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVA_RS06275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVA_RS06310	COG3409	Peptidoglycan-binding domain 1 protein
AVA_RS06310	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVA_RS06320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVA_RS06355	COG2770	Histidine kinase
AVA_RS06355	COG3437	response regulator, receiver
AVA_RS06395	COG0745	RESPONSE REGULATOR receiver
AVA_RS06410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVA_RS06415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVA_RS06435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AVA_RS06445	COG0039	L-malate dehydrogenase activity
AVA_RS06455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVA_RS06465	COG0436	Aminotransferase
AVA_RS06480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVA_RS06485	COG1530	ribonuclease E activity
AVA_RS06490	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AVA_RS06505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AVA_RS06510	COG0051	transcription antitermination factor activity, RNA binding
AVA_RS06515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AVA_RS06520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVA_RS06525	COG0049	tRNA binding
AVA_RS06530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AVA_RS06535	COG0316	Belongs to the HesB IscA family
AVA_RS06540	COG0662	Cupin 2, conserved barrel domain protein
AVA_RS06540	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AVA_RS06550	COG0070	glutamate synthase
AVA_RS06550	COG0067	glutamate synthase
AVA_RS06550	COG0069	glutamate synthase activity
AVA_RS06565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AVA_RS06580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AVA_RS06605	COG0740	serine-type endopeptidase activity
AVA_RS06610	COG0740	serine-type endopeptidase activity
AVA_RS06615	COG2304	oxidoreductase activity
AVA_RS06620	COG2304	oxidoreductase activity
AVA_RS06625	COG0346	lactoylglutathione lyase activity
AVA_RS06640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AVA_RS06660	COG0443	Heat shock 70 kDa protein
AVA_RS06680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AVA_RS06685	COG0557	exoribonuclease II activity
AVA_RS06755	COG3655	Transcriptional regulator
AVA_RS06830	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AVA_RS06835	COG0484	heat shock protein binding
AVA_RS06860	COG3903	Transcriptional regulator
AVA_RS06860	COG2319	Wd-40 repeat
AVA_RS06870	COG0450	alkyl hydroperoxide reductase
AVA_RS06875	COG2304	oxidoreductase activity
AVA_RS06890	COG0438	transferase activity, transferring glycosyl groups
AVA_RS06905	COG0438	transferase activity, transferring glycosyl groups
AVA_RS06925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVA_RS06925	COG0426	domain, Protein
AVA_RS06940	COG0426	domain, Protein
AVA_RS06940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVA_RS06955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVA_RS06960	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AVA_RS06980	COG0438	transferase activity, transferring glycosyl groups
AVA_RS07005	COG1216	Glycosyl transferase, family 2
AVA_RS07010	COG3206	protein involved in exopolysaccharide biosynthesis
AVA_RS07010	COG0489	protein tyrosine kinase activity
AVA_RS07065	COG2268	Band 7 protein
AVA_RS07080	COG2223	nitrite transmembrane transporter activity
AVA_RS07090	COG0456	acetyltransferase
AVA_RS07100	COG0662	Cupin 2, conserved barrel domain protein
AVA_RS07100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AVA_RS07120	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AVA_RS07125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVA_RS07130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVA_RS07165	COG4942	peptidase
AVA_RS07170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AVA_RS07170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AVA_RS07175	COG1496	oxidoreductase activity
AVA_RS07180	COG0385	Bile acid
AVA_RS07185	COG4399	Belongs to the UPF0754 family
AVA_RS07190	COG2226	methyltransferase
AVA_RS07195	COG2204	response regulator
AVA_RS07205	COG1074	ATP-dependent DNA helicase activity
AVA_RS07260	COG1136	(ABC) transporter
AVA_RS07265	COG0501	Belongs to the peptidase M48B family
AVA_RS07270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AVA_RS07280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVA_RS07290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVA_RS07290	COG0426	domain, Protein
AVA_RS07295	COG0426	domain, Protein
AVA_RS07295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVA_RS07305	COG4636	protein conserved in cyanobacteria
AVA_RS07330	COG0745	RESPONSE REGULATOR receiver
AVA_RS07355	COG1131	(ABC) transporter
AVA_RS07380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVA_RS07380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AVA_RS07400	COG1077	Cell shape determining protein MreB Mrl
AVA_RS07405	COG0629	single-stranded DNA binding
AVA_RS07415	COG0475	glutathione-regulated potassium exporter activity
AVA_RS07420	COG2247	cell wall binding repeat
AVA_RS07420	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVA_RS07430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AVA_RS07440	COG0142	geranyltranstransferase activity
AVA_RS07460	COG1305	Transglutaminase-like
AVA_RS07465	COG2052	Domain of unknown function (DUF370)
AVA_RS07470	COG0194	GDP metabolic process
AVA_RS07490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AVA_RS07505	COG0454	-acetyltransferase
AVA_RS07520	COG2890	protein-(glutamine-N5) methyltransferase activity
AVA_RS07535	COG0454	-acetyltransferase
AVA_RS07545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVA_RS07550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AVA_RS07555	COG0022	dehydrogenase e1 component
AVA_RS07555	COG0508	dehydrogenase complex catalyzes the overall conversion of
AVA_RS07575	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AVA_RS07585	COG0644	oxidoreductase
AVA_RS07590	COG0745	RESPONSE REGULATOR receiver
AVA_RS07595	COG0429	hydrolase of the alpha beta-hydrolase fold
AVA_RS07625	COG0539	negative regulation of cytoplasmic translation
AVA_RS07645	COG0747	negative chemotaxis
AVA_RS07650	COG0601	transmembrane transport
AVA_RS07655	COG0328	RNA-DNA hybrid ribonuclease activity
AVA_RS07675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AVA_RS07680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AVA_RS07695	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AVA_RS07700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AVA_RS07705	COG0772	Belongs to the SEDS family
AVA_RS07735	COG0438	transferase activity, transferring glycosyl groups
AVA_RS07745	COG2010	Cytochrome c
AVA_RS07760	COG1950	PFAM Membrane protein of
AVA_RS07770	COG2183	response to ionizing radiation
AVA_RS07780	COG1192	Involved in chromosome partitioning
AVA_RS07820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVA_RS07845	COG2217	Heavy metal translocating P-type atpase
AVA_RS07865	COG0515	serine threonine protein kinase
AVA_RS07865	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS07885	COG4249	Peptidase C14 caspase catalytic subunit p20
AVA_RS07885	COG2319	Wd-40 repeat
AVA_RS07895	COG2197	response regulator
AVA_RS07900	COG5001	Diguanylate cyclase
AVA_RS07905	COG0784	Response regulator, receiver
AVA_RS07905	COG2198	Histidine kinase
AVA_RS07905	COG5002	protein histidine kinase activity
AVA_RS07910	COG0784	Response regulator, receiver
AVA_RS07910	COG5002	protein histidine kinase activity
AVA_RS07925	COG2205	protein histidine kinase activity
AVA_RS07925	COG0784	Response regulator, receiver
AVA_RS07925	COG5002	protein histidine kinase activity
AVA_RS07935	COG0745	RESPONSE REGULATOR receiver
AVA_RS07945	COG1215	transferase activity, transferring glycosyl groups
AVA_RS07970	COG0300	oxidoreductase activity
AVA_RS07980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVA_RS07985	COG2226	methyltransferase
AVA_RS07995	COG0402	S-adenosylhomocysteine deaminase activity
AVA_RS08040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AVA_RS08050	COG4636	protein conserved in cyanobacteria
AVA_RS08060	COG1830	Aldolase
AVA_RS08070	COG0515	serine threonine protein kinase
AVA_RS08070	COG3266	domain, Protein
AVA_RS08075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVA_RS08080	COG2226	methyltransferase
AVA_RS08100	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AVA_RS08105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AVA_RS08110	COG1121	(ABC) transporter
AVA_RS08125	COG0587	DNA-directed DNA polymerase activity
AVA_RS08155	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS08155	COG0318	PFAM AMP-dependent synthetase and ligase
AVA_RS08155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVA_RS08155	COG3321	synthase
AVA_RS08155	COG0300	oxidoreductase activity
AVA_RS08190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AVA_RS08195	COG4178	(ABC) transporter
AVA_RS08210	COG3621	Patatin-like phospholipase
AVA_RS08220	COG4178	(ABC) transporter
AVA_RS08230	COG2319	Wd-40 repeat
AVA_RS08230	COG1672	PFAM Archaeal ATPase
AVA_RS08245	COG3437	response regulator, receiver
AVA_RS08265	COG0668	transmembrane transport
AVA_RS08270	COG0475	glutathione-regulated potassium exporter activity
AVA_RS08320	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
AVA_RS08330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AVA_RS08345	COG1696	Membrane protein involved in D-alanine export
AVA_RS08350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVA_RS08350	COG4221	oxidoreductase activity
AVA_RS08350	COG3321	synthase
AVA_RS08350	COG0300	oxidoreductase activity
AVA_RS08355	COG1960	acyl-CoA dehydrogenase activity
AVA_RS08360	COG0318	PFAM AMP-dependent synthetase and ligase
AVA_RS08370	COG0354	folic acid binding
AVA_RS08380	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AVA_RS08390	COG3959	Transketolase, thiamine diphosphate binding domain
AVA_RS08410	COG0435	Glutathione S-transferase
AVA_RS08420	COG1420	regulation of RNA biosynthetic process
AVA_RS08450	COG1045	serine acetyltransferase
AVA_RS08455	COG0259	pyridoxamine-phosphate oxidase activity
AVA_RS08470	COG4771	TonB-dependent receptor
AVA_RS08480	COG1271	oxidase subunit
AVA_RS08505	COG0724	RNA recognition motif
AVA_RS08510	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AVA_RS08515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AVA_RS08520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AVA_RS08525	COG3429	Glucose-6-phosphate dehydrogenase subunit
AVA_RS08525	COG3409	Peptidoglycan-binding domain 1 protein
AVA_RS08545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AVA_RS08555	COG0616	signal peptide processing
AVA_RS08565	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AVA_RS08580	COG0469	pyruvate kinase activity
AVA_RS08610	COG3266	domain, Protein
AVA_RS08610	COG0515	serine threonine protein kinase
AVA_RS08620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AVA_RS08635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AVA_RS08655	COG3609	addiction module antidote protein, CC2985 family
AVA_RS08660	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AVA_RS08660	COG0617	tRNA 3'-terminal CCA addition
AVA_RS08660	COG0517	IMP dehydrogenase activity
AVA_RS08665	COG0419	ATPase involved in DNA repair
AVA_RS08700	COG2205	protein histidine kinase activity
AVA_RS08700	COG0784	Response regulator, receiver
AVA_RS08710	COG1361	Conserved repeat domain
AVA_RS08715	COG5002	protein histidine kinase activity
AVA_RS08745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AVA_RS08775	COG0750	zinc metalloprotease
AVA_RS08780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AVA_RS08785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AVA_RS08795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AVA_RS08810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVA_RS08850	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS08855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVA_RS08860	COG3118	belongs to the thioredoxin family
AVA_RS08870	COG0583	DNA-binding transcription factor activity
AVA_RS08875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS08880	COG0018	arginyl-trna synthetase
AVA_RS08885	COG0561	phosphatase activity
AVA_RS08890	COG1122	ATPase activity
AVA_RS08900	COG0310	cobalt ion transport
AVA_RS08905	COG1122	ATPase activity
AVA_RS08915	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
AVA_RS08920	COG0310	cobalt ion transport
AVA_RS08925	COG2132	Multicopper oxidase
AVA_RS08940	COG0672	)-iron permease
AVA_RS08945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVA_RS08955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVA_RS08960	COG0776	regulation of translation
AVA_RS08965	COG1797	cobyrinic acid a,c-diamide synthase activity
AVA_RS08970	COG1649	PFAM Uncharacterised BCR, COG1649
AVA_RS08995	COG1446	asparaginase
AVA_RS09000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVA_RS09005	COG3437	response regulator, receiver
AVA_RS09010	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AVA_RS09010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVA_RS09035	COG0045	succinate-CoA ligase (ADP-forming) activity
AVA_RS09045	COG2988	succinylglutamate desuccinylase activity
AVA_RS09050	COG1770	oligopeptidase
AVA_RS09060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AVA_RS09065	COG3320	Male sterility
AVA_RS09065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVA_RS09080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AVA_RS09085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AVA_RS09095	COG1032	radical SAM domain protein
AVA_RS09105	COG1994	Peptidase M50
AVA_RS09105	COG0517	IMP dehydrogenase activity
AVA_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS09125	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AVA_RS09130	COG0426	domain, Protein
AVA_RS09130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVA_RS09135	COG0426	domain, Protein
AVA_RS09135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AVA_RS09150	COG0165	Argininosuccinate lyase
AVA_RS09160	COG1691	(AIR) carboxylase
AVA_RS09165	COG0747	negative chemotaxis
AVA_RS09170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AVA_RS09175	COG0336	Belongs to the RNA methyltransferase TrmD family
AVA_RS09180	COG4242	Belongs to the peptidase S51 family
AVA_RS09185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AVA_RS09185	COG0189	ligase activity
AVA_RS09190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVA_RS09195	COG3266	domain, Protein
AVA_RS09195	COG0515	serine threonine protein kinase
AVA_RS09205	COG0575	Belongs to the CDS family
AVA_RS09215	COG1187	pseudouridine synthase activity
AVA_RS09220	COG1426	Protein conserved in bacteria
AVA_RS09225	COG1640	4-alpha-glucanotransferase
AVA_RS09235	COG0251	oxidation-reduction process
AVA_RS09245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVA_RS09265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AVA_RS09285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AVA_RS09290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVA_RS09295	COG0189	ligase activity
AVA_RS09300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AVA_RS09320	COG4249	Peptidase C14 caspase catalytic subunit p20
AVA_RS09320	COG2319	Wd-40 repeat
AVA_RS09335	COG1191	sigma factor activity
AVA_RS09380	COG4447	cellulose binding
AVA_RS09385	COG1773	rubredoxin
AVA_RS09390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS09395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS09400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS09435	COG3266	domain, Protein
AVA_RS09435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AVA_RS09445	COG0195	Participates in both transcription termination and antitermination
AVA_RS09450	COG0779	Required for maturation of 30S ribosomal subunits
AVA_RS09475	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AVA_RS09480	COG0745	RESPONSE REGULATOR receiver
AVA_RS09535	COG0516	GMP reductase activity
AVA_RS09535	COG0517	IMP dehydrogenase activity
AVA_RS09540	COG0494	nUDIX hydrolase
AVA_RS09550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVA_RS09555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AVA_RS09560	COG0783	Belongs to the Dps family
AVA_RS09570	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AVA_RS09595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AVA_RS09600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVA_RS09610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AVA_RS09615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVA_RS09630	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AVA_RS09635	COG0401	homolog of Blt101
AVA_RS09640	COG0023	Translation Initiation Factor
AVA_RS09645	COG0133	tryptophan synthase activity
AVA_RS09660	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AVA_RS09675	COG0745	RESPONSE REGULATOR receiver
AVA_RS09680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AVA_RS09690	COG0702	epimerase
AVA_RS09695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVA_RS09700	COG0745	RESPONSE REGULATOR receiver
AVA_RS09720	COG0134	indole-3-glycerol-phosphate synthase activity
AVA_RS09725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVA_RS09790	COG1429	ligase activity, forming nitrogen-metal bonds
AVA_RS09795	COG1132	(ABC) transporter
AVA_RS09800	COG1132	(ABC) transporter
AVA_RS09810	COG0745	RESPONSE REGULATOR receiver
AVA_RS09815	COG5000	phosphorelay sensor kinase activity
AVA_RS09815	COG5002	protein histidine kinase activity
AVA_RS09820	COG0113	porphobilinogen synthase activity
AVA_RS09825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVA_RS09830	COG0523	cobalamin synthesis protein
AVA_RS09835	COG0302	gtp cyclohydrolase
AVA_RS09845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVA_RS09850	COG0513	Belongs to the DEAD box helicase family
AVA_RS09865	COG1132	(ABC) transporter
AVA_RS09875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AVA_RS09890	COG2234	aminopeptidase activity
AVA_RS09900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AVA_RS09925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AVA_RS09930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AVA_RS09955	COG2954	triphosphatase activity
AVA_RS09970	COG1846	Transcriptional regulator
AVA_RS09980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVA_RS10000	COG2124	cytochrome p450
AVA_RS10005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS10015	COG0724	RNA recognition motif
AVA_RS10020	COG1218	3'(2'),5'-bisphosphate nucleotidase
AVA_RS10030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AVA_RS10040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVA_RS10055	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AVA_RS10070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVA_RS10075	COG3266	domain, Protein
AVA_RS10075	COG0515	serine threonine protein kinase
AVA_RS10080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AVA_RS10090	COG0857	belongs to the CobB CobQ family
AVA_RS10105	COG1666	GTP binding
AVA_RS10110	COG0625	glutathione transferase activity
AVA_RS10130	COG1070	Carbohydrate kinase
AVA_RS10135	COG2971	BadF BadG BcrA BcrD
AVA_RS10150	COG3237	CsbD-like
AVA_RS10185	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AVA_RS10195	COG1404	Belongs to the peptidase S8 family
AVA_RS10205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AVA_RS10215	COG0484	heat shock protein binding
AVA_RS10225	COG0450	alkyl hydroperoxide reductase
AVA_RS10245	COG4585	Histidine kinase
AVA_RS10250	COG2197	response regulator
AVA_RS10260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS10285	COG0440	acetolactate synthase activity
AVA_RS10300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AVA_RS10335	COG4172	Belongs to the ABC transporter superfamily
AVA_RS10340	COG0629	single-stranded DNA binding
AVA_RS10360	COG3842	ATPase activity
AVA_RS10370	COG3631	Ketosteroid isomerase-related protein
AVA_RS10375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AVA_RS10380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AVA_RS10385	COG0412	Dienelactone hydrolase
AVA_RS10400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AVA_RS10410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AVA_RS10415	COG0052	Belongs to the universal ribosomal protein uS2 family
AVA_RS10430	COG1216	Glycosyl transferase, family 2
AVA_RS10450	COG0137	argininosuccinate synthase activity
AVA_RS10455	COG0586	Pfam SNARE associated Golgi protein
AVA_RS10470	COG0360	Binds together with S18 to 16S ribosomal RNA
AVA_RS10475	COG0179	Fumarylacetoacetate (FAA) hydrolase
AVA_RS10490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AVA_RS10500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVA_RS10505	COG1058	Belongs to the CinA family
AVA_RS10505	COG1546	Belongs to the CinA family
AVA_RS10510	COG4636	protein conserved in cyanobacteria
AVA_RS10525	COG0159	tryptophan synthase activity
AVA_RS10535	COG0515	serine threonine protein kinase
AVA_RS10535	COG3266	domain, Protein
AVA_RS10555	COG4115	mRNA cleavage
AVA_RS10565	COG0038	chloride channel
AVA_RS10585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVA_RS10590	COG0395	ABC-type sugar transport system, permease component
AVA_RS10595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AVA_RS10600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVA_RS10605	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AVA_RS10615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVA_RS10620	COG0438	transferase activity, transferring glycosyl groups
AVA_RS10640	COG2124	cytochrome p450
AVA_RS10645	COG2319	Wd-40 repeat
AVA_RS10645	COG4249	Peptidase C14 caspase catalytic subunit p20
AVA_RS10670	COG0515	serine threonine protein kinase
AVA_RS10670	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS10680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVA_RS10685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AVA_RS10690	COG0514	ATP-dependent DNA helicase (RecQ)
AVA_RS10695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AVA_RS10700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AVA_RS10705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AVA_RS10710	COG1234	tRNA 3'-trailer cleavage
AVA_RS10715	COG0196	riboflavin kinase activity
AVA_RS10720	COG0714	Associated with various cellular activities
AVA_RS10740	COG0653	protein targeting
AVA_RS10745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AVA_RS10755	COG0436	Aminotransferase
AVA_RS10770	COG4680	protein conserved in bacteria
AVA_RS10775	COG0457	Tetratricopeptide repeat
AVA_RS10775	COG0463	Glycosyl transferase, family 2
AVA_RS10790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AVA_RS10805	COG1696	Membrane protein involved in D-alanine export
AVA_RS10820	COG1404	Belongs to the peptidase S8 family
AVA_RS10820	COG4935	Belongs to the peptidase S8 family
AVA_RS10830	COG0590	tRNA wobble adenosine to inosine editing
AVA_RS10835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVA_RS10840	COG0702	epimerase
AVA_RS10890	COG1007	ATP synthesis coupled electron transport
AVA_RS10910	COG1982	Orn Lys Arg decarboxylase major
AVA_RS10930	COG0038	chloride channel
AVA_RS10945	COG0288	reversible hydration of carbon dioxide
AVA_RS10955	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AVA_RS10965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AVA_RS10970	COG1609	Transcriptional regulator
AVA_RS10975	COG1879	ABC-type sugar transport system periplasmic component
AVA_RS10980	COG1129	ABC transporter
AVA_RS10985	COG1172	Belongs to the binding-protein-dependent transport system permease family
AVA_RS10995	COG3659	wide pore channel activity
AVA_RS11005	COG3852	Histidine kinase
AVA_RS11010	COG0406	alpha-ribazole phosphatase activity
AVA_RS11040	COG5635	Nacht domain
AVA_RS11040	COG2319	Wd-40 repeat
AVA_RS11070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVA_RS11115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AVA_RS11120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AVA_RS11135	COG4636	protein conserved in cyanobacteria
AVA_RS11170	COG0419	ATPase involved in DNA repair
AVA_RS11195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVA_RS11200	COG1742	UPF0060 membrane protein
AVA_RS11205	COG1215	transferase activity, transferring glycosyl groups
AVA_RS11210	COG1473	amidohydrolase
AVA_RS11225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVA_RS11225	COG0072	phenylalanine-tRNA ligase activity
AVA_RS11230	COG4956	integral membrane protein (PIN domain superfamily)
AVA_RS11235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVA_RS11250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AVA_RS11260	COG0546	phosphoglycolate phosphatase activity
AVA_RS11265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AVA_RS11270	COG3631	Ketosteroid isomerase-related protein
AVA_RS11285	COG0628	permease
AVA_RS11295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVA_RS11300	COG0497	DNA recombination
AVA_RS11330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVA_RS11335	COG3150	esterase
AVA_RS11340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVA_RS11360	COG1695	Transcriptional regulator
AVA_RS11375	COG1136	(ABC) transporter
AVA_RS11375	COG0577	efflux transmembrane transporter activity
AVA_RS11380	COG3540	Alkaline phosphatase
AVA_RS11385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AVA_RS11405	COG2909	trisaccharide binding
AVA_RS11430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AVA_RS11435	COG0124	histidyl-tRNA synthetase
AVA_RS11450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVA_RS11460	COG1940	carbohydrate kinase activity
AVA_RS11470	COG0504	CTP synthase activity
AVA_RS11475	COG0860	N-Acetylmuramoyl-L-alanine amidase
AVA_RS11500	COG1834	amidinotransferase
AVA_RS11525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AVA_RS11545	COG0583	DNA-binding transcription factor activity
AVA_RS11550	COG0438	transferase activity, transferring glycosyl groups
AVA_RS11570	COG0748	coenzyme F420 binding
AVA_RS11580	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AVA_RS11600	COG0714	Associated with various cellular activities
AVA_RS11620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AVA_RS11625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AVA_RS11645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AVA_RS11650	COG3842	ATPase activity
AVA_RS11655	COG0768	penicillin binding
AVA_RS11660	COG0848	biopolymer transport protein
AVA_RS11665	COG0811	peptide transport
AVA_RS11675	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS11690	COG0442	prolyl-tRNA aminoacylation
AVA_RS11700	COG0640	Transcriptional regulator
AVA_RS11705	COG0511	ligase activity, forming carbon-carbon bonds
AVA_RS11710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AVA_RS11715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AVA_RS11720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AVA_RS11725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AVA_RS11730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AVA_RS11735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AVA_RS11740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AVA_RS11745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AVA_RS11750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVA_RS11755	COG0745	RESPONSE REGULATOR receiver
AVA_RS11760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AVA_RS11775	COG2205	protein histidine kinase activity
AVA_RS11775	COG2198	Histidine kinase
AVA_RS11775	COG0784	Response regulator, receiver
AVA_RS11785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS11795	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AVA_RS11810	COG0542	response to heat
AVA_RS11835	COG3001	Fructosamine kinase
AVA_RS11840	COG0612	Peptidase, M16
AVA_RS11865	COG0463	Glycosyl transferase, family 2
AVA_RS11870	COG1063	alcohol dehydrogenase
AVA_RS11875	COG2831	hemolysin activation secretion protein
AVA_RS11895	COG3210	domain, Protein
AVA_RS11905	COG0436	Aminotransferase
AVA_RS11915	COG4953	penicillin-binding protein 1C
AVA_RS11920	COG2373	Large extracellular alpha-helical protein
AVA_RS11925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AVA_RS11945	COG1253	flavin adenine dinucleotide binding
AVA_RS11950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AVA_RS11955	COG0673	inositol 2-dehydrogenase activity
AVA_RS11960	COG0586	Pfam SNARE associated Golgi protein
AVA_RS11975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVA_RS11980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AVA_RS12005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AVA_RS12005	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AVA_RS12040	COG2119	membrane
AVA_RS12050	COG0303	'Molybdopterin
AVA_RS12060	COG2046	Belongs to the sulfate adenylyltransferase family
AVA_RS12090	COG0463	Glycosyl transferase, family 2
AVA_RS12105	COG2226	methyltransferase
AVA_RS12145	COG2274	protein secretion by the type I secretion system
AVA_RS12160	COG2204	response regulator
AVA_RS12170	COG1234	tRNA 3'-trailer cleavage
AVA_RS12180	COG2885	chlorophyll binding
AVA_RS12185	COG2885	chlorophyll binding
AVA_RS12215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVA_RS12230	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AVA_RS12255	COG0745	RESPONSE REGULATOR receiver
AVA_RS12260	COG5002	protein histidine kinase activity
AVA_RS12280	COG0725	ABC transporter, periplasmic molybdate-binding protein
AVA_RS12300	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS12310	COG2239	Acts as a magnesium transporter
AVA_RS12315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVA_RS12330	COG0438	transferase activity, transferring glycosyl groups
AVA_RS12335	COG1132	(ABC) transporter
AVA_RS12345	COG3659	wide pore channel activity
AVA_RS12355	COG5002	protein histidine kinase activity
AVA_RS12360	COG0745	RESPONSE REGULATOR receiver
AVA_RS12375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVA_RS12385	COG2066	Belongs to the glutaminase family
AVA_RS12395	COG0800	Aldolase
AVA_RS12465	COG1304	FMN binding
AVA_RS12470	COG0616	signal peptide processing
AVA_RS12485	COG0811	peptide transport
AVA_RS12495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AVA_RS12505	COG0601	transmembrane transport
AVA_RS12510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AVA_RS12535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AVA_RS12550	COG0573	inorganic phosphate transmembrane transporter activity
AVA_RS12555	COG0581	inorganic phosphate transmembrane transporter activity
AVA_RS12560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVA_RS12565	COG2175	clavaminate synthase activity
AVA_RS12570	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AVA_RS12585	COG1942	4-Oxalocrotonate Tautomerase
AVA_RS12595	COG1309	transcriptional regulator
AVA_RS12600	COG1979	alcohol dehydrogenase
AVA_RS12610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS12615	COG0191	fructose-bisphosphate aldolase activity
AVA_RS12645	COG2442	InterPro IPR007367
AVA_RS12665	COG2081	HI0933 family
AVA_RS12690	COG0484	heat shock protein binding
AVA_RS12695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVA_RS12700	COG1959	2 iron, 2 sulfur cluster binding
AVA_RS12705	COG3659	wide pore channel activity
AVA_RS12710	COG2154	pterin-4-alpha-carbinolamine dehydratase
AVA_RS12725	COG1122	ATPase activity
AVA_RS12730	COG3688	RNA-binding protein containing a PIN domain
AVA_RS12745	COG0187	DNA topoisomerase II activity
AVA_RS12745	COG1372	Participates in initiation and elongation during chromosome replication
AVA_RS12750	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AVA_RS12760	COG0277	FAD linked oxidase domain protein
AVA_RS12770	COG1649	PFAM Uncharacterised BCR, COG1649
AVA_RS12780	COG2203	Gaf domain
AVA_RS12780	COG3706	GGDEF domain
AVA_RS12780	COG4251	negative regulation of phosphorylation
AVA_RS12780	COG5001	Diguanylate cyclase
AVA_RS12800	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AVA_RS12805	COG0515	serine threonine protein kinase
AVA_RS12805	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS12825	COG0395	ABC-type sugar transport system, permease component
AVA_RS12830	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AVA_RS12835	COG5322	oxidoreductase activity
AVA_RS12840	COG0825	malonyl-CoA metabolic process
AVA_RS12845	COG0300	oxidoreductase activity
AVA_RS12850	COG0302	gtp cyclohydrolase
AVA_RS12855	COG0135	phosphoribosylanthranilate isomerase activity
AVA_RS12890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVA_RS12905	COG1309	transcriptional regulator
AVA_RS12910	COG0335	large ribosomal subunit rRNA binding
AVA_RS12920	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AVA_RS12925	COG0250	Participates in transcription elongation, termination and antitermination
AVA_RS12930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AVA_RS12935	COG0081	regulation of translation
AVA_RS12940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AVA_RS12945	COG0222	ribosome binding
AVA_RS12955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVA_RS12975	COG0438	transferase activity, transferring glycosyl groups
AVA_RS12985	COG2205	protein histidine kinase activity
AVA_RS12985	COG0784	Response regulator, receiver
AVA_RS13005	COG2885	chlorophyll binding
AVA_RS13060	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AVA_RS13110	COG1475	DNA binding
AVA_RS13120	COG3321	synthase
AVA_RS13120	COG0604	alcohol dehydrogenase
AVA_RS13125	COG4221	oxidoreductase activity
AVA_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS13125	COG3321	synthase
AVA_RS13125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AVA_RS13135	COG0300	oxidoreductase activity
AVA_RS13135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVA_RS13135	COG3321	synthase
AVA_RS13135	COG4221	oxidoreductase activity
AVA_RS13140	COG2070	2-Nitropropane dioxygenase
AVA_RS13140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVA_RS13145	COG3320	Male sterility
AVA_RS13145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVA_RS13150	COG0300	oxidoreductase activity
AVA_RS13155	COG2091	lysine biosynthetic process via aminoadipic acid
AVA_RS13165	COG3845	ABC transporter
AVA_RS13180	COG4603	Belongs to the binding-protein-dependent transport system permease family
AVA_RS13185	COG1079	Belongs to the binding-protein-dependent transport system permease family
AVA_RS13195	COG2226	methyltransferase
AVA_RS13220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AVA_RS13225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AVA_RS13230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVA_RS13235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVA_RS13240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AVA_RS13245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AVA_RS13250	COG0356	it plays a direct role in the translocation of protons across the membrane
AVA_RS13260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVA_RS13265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AVA_RS13265	COG0237	dephospho-CoA kinase activity
AVA_RS13285	COG2912	Transglutaminase-like superfamily
AVA_RS13310	COG3903	Transcriptional regulator
AVA_RS13310	COG2319	Wd-40 repeat
AVA_RS13320	COG0297	glycogen (starch) synthase activity
AVA_RS13325	COG1169	isochorismate synthase
AVA_RS13330	COG1575	Belongs to the MenA family. Type 1 subfamily
AVA_RS13340	COG4948	Mandelate Racemase Muconate Lactonizing
AVA_RS13350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AVA_RS13430	COG1193	negative regulation of DNA recombination
AVA_RS13440	COG0516	GMP reductase activity
AVA_RS13445	COG3118	belongs to the thioredoxin family
AVA_RS13470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVA_RS13475	COG0489	protein tyrosine kinase activity
AVA_RS13495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AVA_RS13510	COG0717	Belongs to the dCTP deaminase family
AVA_RS13520	COG0563	adenylate kinase activity
AVA_RS13525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AVA_RS13535	COG1127	ABC transporter
AVA_RS13545	COG0784	Response regulator, receiver
AVA_RS13545	COG5002	protein histidine kinase activity
AVA_RS13555	COG0728	peptidoglycan biosynthetic process
AVA_RS13560	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS13565	COG1316	TRANSCRIPTIONal
AVA_RS13575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVA_RS13580	COG1131	(ABC) transporter
AVA_RS13590	COG2815	serine threonine protein kinase
AVA_RS13590	COG0515	serine threonine protein kinase
AVA_RS13630	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AVA_RS13635	COG0009	L-threonylcarbamoyladenylate synthase
AVA_RS13650	COG0514	ATP-dependent DNA helicase (RecQ)
AVA_RS13670	COG0628	permease
AVA_RS13675	COG1051	belongs to the nudix hydrolase family
AVA_RS13685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AVA_RS13695	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AVA_RS13715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AVA_RS13720	COG5001	Diguanylate cyclase
AVA_RS13730	COG2062	phosphohistidine phosphatase, SixA
AVA_RS13735	COG0372	Belongs to the citrate synthase family
AVA_RS13740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AVA_RS13745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS13750	COG0839	Belongs to the complex I subunit 6 family
AVA_RS13755	COG0713	ATP synthesis coupled electron transport
AVA_RS13760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AVA_RS13785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AVA_RS13805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AVA_RS13810	COG0416	fatty acid biosynthetic process
AVA_RS13815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AVA_RS13820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVA_RS13825	COG0204	Acyl-transferase
AVA_RS13825	COG0318	PFAM AMP-dependent synthetase and ligase
AVA_RS13830	COG0628	permease
AVA_RS13855	COG0484	heat shock protein binding
AVA_RS13865	COG1408	metallophosphoesterase
AVA_RS13870	COG1408	metallophosphoesterase
AVA_RS13875	COG0025	NhaP-type Na H and K H
AVA_RS13900	COG3794	PFAM blue (type 1) copper domain protein
AVA_RS13905	COG2010	Cytochrome c
AVA_RS13910	COG0395	ABC-type sugar transport system, permease component
AVA_RS13925	COG0784	Response regulator, receiver
AVA_RS13930	COG0398	Pfam SNARE associated Golgi protein
AVA_RS13940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVA_RS13965	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS13970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AVA_RS13975	COG0509	glycine decarboxylation via glycine cleavage system
AVA_RS13980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVA_RS13980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AVA_RS13985	COG0312	modulator of DNA gyrase
AVA_RS13990	COG0312	modulator of DNA gyrase
AVA_RS13995	COG1981	membrane
AVA_RS14000	COG1253	flavin adenine dinucleotide binding
AVA_RS14005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AVA_RS14025	COG0784	Response regulator, receiver
AVA_RS14025	COG5002	protein histidine kinase activity
AVA_RS14045	COG0398	Pfam SNARE associated Golgi protein
AVA_RS14055	COG0006	proline dipeptidase activity
AVA_RS14070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVA_RS14070	COG0512	Glutamine amidotransferase of anthranilate synthase
AVA_RS14075	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AVA_RS14080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AVA_RS14085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AVA_RS14100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVA_RS14105	COG3903	Transcriptional regulator
AVA_RS14105	COG2319	Wd-40 repeat
AVA_RS14115	COG1301	dicarboxylic acid transport
AVA_RS14135	COG0083	homoserine kinase activity
AVA_RS14145	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS14170	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS14180	COG2815	serine threonine protein kinase
AVA_RS14180	COG0515	serine threonine protein kinase
AVA_RS14185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AVA_RS14190	COG0784	Response regulator, receiver
AVA_RS14190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AVA_RS14230	COG1846	Transcriptional regulator
AVA_RS14255	COG3903	Transcriptional regulator
AVA_RS14255	COG2319	Wd-40 repeat
AVA_RS14265	COG0156	8-amino-7-oxononanoate synthase activity
AVA_RS14270	COG0632	four-way junction helicase activity
AVA_RS14275	COG0561	phosphatase activity
AVA_RS14285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AVA_RS14290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AVA_RS14295	COG1054	Belongs to the UPF0176 family
AVA_RS14325	COG1120	ATPase activity
AVA_RS14365	COG0076	glutamate decarboxylase activity
AVA_RS14390	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AVA_RS14400	COG0515	serine threonine protein kinase
AVA_RS14400	COG2815	serine threonine protein kinase
AVA_RS14430	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS14430	COG0515	serine threonine protein kinase
AVA_RS14435	COG1136	(ABC) transporter
AVA_RS14445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AVA_RS14475	COG1136	(ABC) transporter
AVA_RS14475	COG0577	efflux transmembrane transporter activity
AVA_RS14480	COG1136	(ABC) transporter
AVA_RS14485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AVA_RS14490	COG1136	(ABC) transporter
AVA_RS14490	COG0577	efflux transmembrane transporter activity
AVA_RS14520	COG4572	Cation transport regulator
AVA_RS14525	COG0783	Belongs to the Dps family
AVA_RS14535	COG2133	pyrroloquinoline quinone binding
AVA_RS14545	COG1017	nitric oxide dioxygenase activity
AVA_RS14545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVA_RS14615	COG4221	oxidoreductase activity
AVA_RS14625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AVA_RS14655	COG1160	GTP binding
AVA_RS14660	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AVA_RS14670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AVA_RS14675	COG1799	cell septum assembly
AVA_RS14680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AVA_RS14685	COG4581	dead DEAH box helicase
AVA_RS14695	COG0463	Glycosyl transferase, family 2
AVA_RS14695	COG1216	Glycosyl transferase, family 2
AVA_RS14710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AVA_RS14715	COG0489	protein tyrosine kinase activity
AVA_RS14715	COG3206	protein involved in exopolysaccharide biosynthesis
AVA_RS14755	COG3956	TIGRFAM MazG family protein
AVA_RS14765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVA_RS14770	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AVA_RS14800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVA_RS14805	COG0784	Response regulator, receiver
AVA_RS14810	COG0564	pseudouridine synthase activity
AVA_RS14825	COG0237	dephospho-CoA kinase activity
AVA_RS14830	COG1413	lyase activity
AVA_RS14835	COG1413	lyase activity
AVA_RS14850	COG0237	dephospho-CoA kinase activity
AVA_RS14855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVA_RS14860	COG1413	lyase activity
AVA_RS14865	COG1413	lyase activity
AVA_RS14870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AVA_RS14875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AVA_RS14880	COG0237	dephospho-CoA kinase activity
AVA_RS14885	COG0237	dephospho-CoA kinase activity
AVA_RS14890	COG2226	methyltransferase
AVA_RS14900	COG1012	belongs to the aldehyde dehydrogenase family
AVA_RS14910	COG2205	protein histidine kinase activity
AVA_RS14915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVA_RS14935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AVA_RS14950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AVA_RS14955	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AVA_RS14960	COG0004	ammonium transporteR
AVA_RS14965	COG0004	ammonium transporteR
AVA_RS14970	COG0004	ammonium transporteR
AVA_RS14995	COG1125	glycine betaine transport
AVA_RS14995	COG0517	IMP dehydrogenase activity
AVA_RS15005	COG1131	(ABC) transporter
AVA_RS15015	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS15055	COG4249	Peptidase C14 caspase catalytic subunit p20
AVA_RS15075	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AVA_RS15080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AVA_RS15085	COG0525	valine-tRNA ligase activity
AVA_RS15100	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AVA_RS15110	COG0473	3-isopropylmalate dehydrogenase activity
AVA_RS15145	COG0180	Tryptophanyl-tRNA synthetase
AVA_RS15175	COG0110	maltose O-acetyltransferase activity
AVA_RS15190	COG5002	protein histidine kinase activity
AVA_RS15195	COG2203	Gaf domain
AVA_RS15195	COG5001	Diguanylate cyclase
AVA_RS15195	COG3706	GGDEF domain
AVA_RS15195	COG4251	negative regulation of phosphorylation
AVA_RS15200	COG0784	Response regulator, receiver
AVA_RS15205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AVA_RS15220	COG0784	Response regulator, receiver
AVA_RS15220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVA_RS15220	COG2198	Histidine kinase
AVA_RS15220	COG2205	protein histidine kinase activity
AVA_RS15225	COG1606	tRNA processing
AVA_RS15250	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AVA_RS15260	COG1132	(ABC) transporter
AVA_RS15275	COG0488	(ABC) transporter
AVA_RS15285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AVA_RS15300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVA_RS15310	COG0347	Belongs to the P(II) protein family
AVA_RS15315	COG0475	glutathione-regulated potassium exporter activity
AVA_RS15335	COG4999	Histidine kinase
AVA_RS15335	COG2205	protein histidine kinase activity
AVA_RS15335	COG3437	response regulator, receiver
AVA_RS15335	COG3850	Histidine kinase
AVA_RS15340	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AVA_RS15350	COG0515	serine threonine protein kinase
AVA_RS15350	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS15355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AVA_RS15390	COG0205	6-phosphofructokinase activity
AVA_RS15395	COG0167	dihydroorotate dehydrogenase activity
AVA_RS15400	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AVA_RS15400	COG1013	pyruvate-flavodoxin oxidoreductase activity
AVA_RS15400	COG0674	pyruvate-flavodoxin oxidoreductase activity
AVA_RS15400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AVA_RS15425	COG0741	lytic transglycosylase activity
AVA_RS15430	COG1410	methionine synthase
AVA_RS15430	COG0646	methionine synthase
AVA_RS15485	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AVA_RS15495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS15520	COG1957	nucleoside hydrolase
AVA_RS15525	COG2197	response regulator
AVA_RS15530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVA_RS15535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AVA_RS15545	COG0071	Belongs to the small heat shock protein (HSP20) family
AVA_RS15550	COG2076	Multidrug Resistance protein
AVA_RS15555	COG4249	Peptidase C14 caspase catalytic subunit p20
AVA_RS15555	COG2319	Wd-40 repeat
AVA_RS15560	COG4249	Peptidase C14 caspase catalytic subunit p20
AVA_RS15560	COG2319	Wd-40 repeat
AVA_RS15570	COG0571	ribonuclease III activity
AVA_RS15585	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AVA_RS15585	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AVA_RS15590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AVA_RS15595	COG4651	solute:proton antiporter activity
AVA_RS15595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AVA_RS15605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AVA_RS15620	COG0405	Gamma-glutamyltransferase
AVA_RS15670	COG0667	Aldo Keto reductase
AVA_RS15705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AVA_RS15730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AVA_RS15750	COG1295	ribonuclease BN
AVA_RS15760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AVA_RS15765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AVA_RS15770	COG0346	lactoylglutathione lyase activity
AVA_RS15805	COG1959	2 iron, 2 sulfur cluster binding
AVA_RS15810	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AVA_RS15815	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AVA_RS15825	COG2226	methyltransferase
AVA_RS15835	COG0724	RNA recognition motif
AVA_RS15840	COG2326	polyphosphate kinase activity
AVA_RS15850	COG1361	Conserved repeat domain
AVA_RS15855	COG0157	Belongs to the NadC ModD family
AVA_RS15890	COG0564	pseudouridine synthase activity
AVA_RS15895	COG0824	Thioesterase
AVA_RS15930	COG0501	Belongs to the peptidase M48B family
AVA_RS15950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AVA_RS15965	COG3385	transposase activity
AVA_RS15995	COG5002	protein histidine kinase activity
AVA_RS16025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AVA_RS16030	COG2201	protein-glutamate methylesterase activity
AVA_RS16050	COG4251	negative regulation of phosphorylation
AVA_RS16050	COG5001	Diguanylate cyclase
AVA_RS16050	COG2203	Gaf domain
AVA_RS16050	COG3706	GGDEF domain
AVA_RS16055	COG2205	protein histidine kinase activity
AVA_RS16065	COG1022	Amp-dependent synthetase and ligase
AVA_RS16090	COG1361	Conserved repeat domain
AVA_RS16110	COG0863	Belongs to the N(4) N(6)-methyltransferase family
AVA_RS16120	COG3240	lipase activity
AVA_RS16135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AVA_RS16140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS16145	COG1151	hydroxylamine reductase activity
AVA_RS16155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVA_RS16165	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVA_RS16170	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AVA_RS16175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AVA_RS16180	COG4942	peptidase
AVA_RS16180	COG1388	LysM domain
AVA_RS16185	COG0275	rRNA processing
AVA_RS16190	COG0501	Belongs to the peptidase M48B family
AVA_RS16195	COG0649	NAD binding
AVA_RS16200	COG0392	lysyltransferase activity
AVA_RS16200	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AVA_RS16220	COG0392	lysyltransferase activity
AVA_RS16225	COG2203	Gaf domain
AVA_RS16235	COG2084	Dehydrogenase
AVA_RS16240	COG3852	Histidine kinase
AVA_RS16245	COG0701	Predicted permease
AVA_RS16270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AVA_RS16285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVA_RS16300	COG2022	thiamine diphosphate biosynthetic process
AVA_RS16300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVA_RS16330	COG2166	iron-sulfur cluster assembly
AVA_RS16335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AVA_RS16340	COG5002	protein histidine kinase activity
AVA_RS16345	COG0151	Belongs to the GarS family
AVA_RS16350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVA_RS16355	COG2076	Multidrug Resistance protein
AVA_RS16360	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AVA_RS16365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AVA_RS16380	COG3706	GGDEF domain
AVA_RS16445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVA_RS16445	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AVA_RS16555	COG1487	ribonuclease activity
AVA_RS16585	COG5635	Nacht domain
AVA_RS16585	COG2319	Wd-40 repeat
AVA_RS16585	COG2319	Wd-40 repeat
AVA_RS16585	COG5635	Nacht domain
AVA_RS16595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVA_RS16605	COG1185	polyribonucleotide nucleotidyltransferase activity
AVA_RS16620	COG4372	Transposase
AVA_RS16625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS16630	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AVA_RS16635	COG0131	Imidazoleglycerol-phosphate dehydratase
AVA_RS16640	COG1131	(ABC) transporter
AVA_RS16650	COG0330	HflC and HflK could
AVA_RS16655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AVA_RS16660	COG0149	triose-phosphate isomerase activity
AVA_RS16665	COG1160	GTP binding
AVA_RS16680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AVA_RS16695	COG0113	porphobilinogen synthase activity
AVA_RS16700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AVA_RS16715	COG0438	transferase activity, transferring glycosyl groups
AVA_RS16740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVA_RS16750	COG3266	domain, Protein
AVA_RS16750	COG0515	serine threonine protein kinase
AVA_RS16760	COG0515	serine threonine protein kinase
AVA_RS16760	COG3266	domain, Protein
AVA_RS16765	COG1429	ligase activity, forming nitrogen-metal bonds
AVA_RS16815	COG1598	PFAM Uncharacterised protein family UPF0150
AVA_RS16840	COG1247	-acetyltransferase
AVA_RS16855	COG0175	sulfate reduction
AVA_RS16870	COG0483	inositol monophosphate 1-phosphatase activity
AVA_RS16905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS16910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AVA_RS16915	COG0003	Pfam Anion-transporting ATPase
AVA_RS16960	COG0463	Glycosyl transferase, family 2
AVA_RS16965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVA_RS16980	COG1091	dTDP-4-dehydrorhamnose reductase activity
AVA_RS17000	COG4106	trans-aconitate 2-methyltransferase activity
AVA_RS17005	COG0438	transferase activity, transferring glycosyl groups
AVA_RS17015	COG0784	Response regulator, receiver
AVA_RS17015	COG2205	protein histidine kinase activity
AVA_RS17030	COG3659	wide pore channel activity
AVA_RS17035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AVA_RS17040	COG0704	Plays a role in the regulation of phosphate uptake
AVA_RS17045	COG5002	protein histidine kinase activity
AVA_RS17050	COG0745	RESPONSE REGULATOR receiver
AVA_RS17065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AVA_RS17090	COG0723	plastoquinol--plastocyanin reductase activity
AVA_RS17095	COG0446	pyridine nucleotide-disulphide oxidoreductase
AVA_RS17100	COG3937	granule-associated protein
AVA_RS17105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AVA_RS17110	COG0631	protein serine/threonine phosphatase activity
AVA_RS17120	COG0515	serine threonine protein kinase
AVA_RS17130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AVA_RS17140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVA_RS17140	COG0574	Belongs to the PEP-utilizing enzyme family
AVA_RS17145	COG1285	pathogenesis
AVA_RS17155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVA_RS17160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AVA_RS17165	COG1305	Transglutaminase-like
AVA_RS17185	COG0463	Glycosyl transferase, family 2
AVA_RS17190	COG2814	Major facilitator Superfamily
AVA_RS17200	COG0315	cyclic pyranopterin monophosphate synthase activity
AVA_RS17215	COG2204	response regulator
AVA_RS17255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AVA_RS17260	COG0438	transferase activity, transferring glycosyl groups
AVA_RS17300	COG1690	Belongs to the RtcB family
AVA_RS17305	COG2226	methyltransferase
AVA_RS17325	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AVA_RS17330	COG1166	arginine decarboxylase activity
AVA_RS17335	COG0105	UTP biosynthetic process
AVA_RS17340	COG0861	Integral membrane protein TerC family
AVA_RS17375	COG0594	ribonuclease P activity
AVA_RS17385	COG0706	membrane insertase activity
AVA_RS17415	COG0793	Belongs to the peptidase S41A family
AVA_RS17420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVA_RS17425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AVA_RS17440	COG0438	transferase activity, transferring glycosyl groups
AVA_RS17450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AVA_RS17455	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AVA_RS17460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVA_RS17480	COG0745	RESPONSE REGULATOR receiver
AVA_RS17490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AVA_RS17510	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS17515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AVA_RS17540	COG0322	excinuclease ABC activity
AVA_RS17550	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS17555	COG0784	Response regulator, receiver
AVA_RS17555	COG5002	protein histidine kinase activity
AVA_RS17560	COG0512	Glutamine amidotransferase of anthranilate synthase
AVA_RS17560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVA_RS17580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AVA_RS17590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AVA_RS17605	COG0850	regulation of cytokinetic process
AVA_RS17610	COG2894	cell division
AVA_RS17615	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AVA_RS17630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AVA_RS17645	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS17685	COG1857	crispr-associated protein
AVA_RS17715	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AVA_RS17715	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AVA_RS17735	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AVA_RS17740	COG0464	growth
AVA_RS17745	COG1404	Belongs to the peptidase S8 family
AVA_RS17775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AVA_RS17785	COG4948	Mandelate Racemase Muconate Lactonizing
AVA_RS17790	COG0494	nUDIX hydrolase
AVA_RS17800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVA_RS17800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AVA_RS17805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AVA_RS17810	COG0148	phosphopyruvate hydratase activity
AVA_RS17820	COG0351	phosphomethylpyrimidine kinase
AVA_RS17870	COG0697	spore germination
AVA_RS17880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AVA_RS17895	COG1012	belongs to the aldehyde dehydrogenase family
AVA_RS17900	COG0515	serine threonine protein kinase
AVA_RS17900	COG2815	serine threonine protein kinase
AVA_RS17920	COG0445	tRNA wobble uridine modification
AVA_RS17935	COG4251	negative regulation of phosphorylation
AVA_RS17950	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AVA_RS17955	COG0475	glutathione-regulated potassium exporter activity
AVA_RS17955	COG0589	response to stress
AVA_RS17960	COG1234	tRNA 3'-trailer cleavage
AVA_RS17965	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AVA_RS17970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AVA_RS18005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AVA_RS18010	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
AVA_RS18015	COG1027	Aspartate ammonia-lyase
AVA_RS18020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AVA_RS18040	COG0018	arginyl-trna synthetase
AVA_RS18060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AVA_RS18080	COG0438	transferase activity, transferring glycosyl groups
AVA_RS18100	COG0438	transferase activity, transferring glycosyl groups
AVA_RS18110	COG1845	cytochrome c oxidase, subunit III
AVA_RS18115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AVA_RS18120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVA_RS18145	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AVA_RS18150	COG2211	Major facilitator Superfamily
AVA_RS18155	COG0515	serine threonine protein kinase
AVA_RS18155	COG2815	serine threonine protein kinase
AVA_RS18175	COG1136	(ABC) transporter
AVA_RS18195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AVA_RS18225	COG0668	transmembrane transport
AVA_RS18270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AVA_RS18275	COG0740	serine-type endopeptidase activity
AVA_RS18280	COG0544	peptidyl-prolyl cis-trans isomerase activity
AVA_RS18285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AVA_RS18290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AVA_RS18295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AVA_RS18300	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVA_RS18320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AVA_RS18325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AVA_RS18330	COG1012	belongs to the aldehyde dehydrogenase family
AVA_RS18345	COG0804	urea catabolic process
AVA_RS18355	COG0832	Belongs to the urease beta subunit family
AVA_RS18360	COG0831	urea catabolic process
AVA_RS18365	COG0829	nickel cation binding
AVA_RS18370	COG1192	Involved in chromosome partitioning
AVA_RS18385	COG0459	protein refolding
AVA_RS18390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AVA_RS18395	COG0745	RESPONSE REGULATOR receiver
AVA_RS18405	COG0017	Asparaginyl-tRNA synthetase
AVA_RS18425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AVA_RS18435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AVA_RS18440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AVA_RS18445	COG1136	(ABC) transporter
AVA_RS18445	COG0577	efflux transmembrane transporter activity
AVA_RS18480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AVA_RS18485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AVA_RS18490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVA_RS18495	COG2048	Heterodisulfide reductase, subunit B
AVA_RS18500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AVA_RS18505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AVA_RS18510	COG0406	alpha-ribazole phosphatase activity
AVA_RS18520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVA_RS18530	COG1116	anion transmembrane transporter activity
AVA_RS18530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS18535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS18545	COG1201	RNA secondary structure unwinding
AVA_RS18580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AVA_RS18580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVA_RS18640	COG0024	Methionine aminopeptidase
AVA_RS18650	COG0612	Peptidase, M16
AVA_RS18675	COG0285	dihydrofolate synthase activity
AVA_RS18725	COG1615	UPF0182 protein
AVA_RS18735	COG0436	Aminotransferase
AVA_RS18740	COG0432	Pfam Uncharacterised protein family UPF0047
AVA_RS18745	COG1494	fructose-1,6-bisphosphatase
AVA_RS18750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AVA_RS18765	COG0640	Transcriptional regulator
AVA_RS18795	COG0166	Belongs to the GPI family
AVA_RS18800	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AVA_RS18805	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AVA_RS18815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AVA_RS18820	COG0798	PFAM Bile acid sodium symporter
AVA_RS18830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AVA_RS18835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AVA_RS18840	COG0523	cobalamin synthesis protein
AVA_RS18845	COG0215	cysteine-tRNA ligase activity
AVA_RS18855	COG0312	modulator of DNA gyrase
AVA_RS18860	COG3852	Histidine kinase
AVA_RS18865	COG1366	Belongs to the anti-sigma-factor antagonist family
AVA_RS18870	COG0745	RESPONSE REGULATOR receiver
AVA_RS18905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVA_RS18915	COG0539	negative regulation of cytoplasmic translation
AVA_RS18920	COG0412	Dienelactone hydrolase
AVA_RS18925	COG2188	Transcriptional regulator
AVA_RS18960	COG3540	Alkaline phosphatase
AVA_RS18965	COG3000	fatty acid hydroxylase
AVA_RS18965	COG0300	oxidoreductase activity
AVA_RS18980	COG0584	glycerophosphoryl diester phosphodiesterase
AVA_RS18990	COG0154	amidase activity
AVA_RS19000	COG0587	DNA-directed DNA polymerase activity
AVA_RS19020	COG1554	hydrolase, family 65, central catalytic
AVA_RS19025	COG0438	transferase activity, transferring glycosyl groups
AVA_RS19035	COG0343	queuine tRNA-ribosyltransferase activity
AVA_RS19050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AVA_RS19055	COG2264	protein methyltransferase activity
AVA_RS19070	COG3118	belongs to the thioredoxin family
AVA_RS19075	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS19080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AVA_RS19085	COG0459	protein refolding
AVA_RS19090	COG5398	heme oxygenase
AVA_RS19095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AVA_RS19105	COG0430	RNA-3'-phosphate cyclase activity
AVA_RS19120	COG1192	Involved in chromosome partitioning
AVA_RS19130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AVA_RS19135	COG2201	protein-glutamate methylesterase activity
AVA_RS19150	COG0840	transmembrane signaling receptor activity
AVA_RS19150	COG2203	Gaf domain
AVA_RS19155	COG2198	Histidine kinase
AVA_RS19155	COG0643	Histidine kinase
AVA_RS19155	COG0784	Response regulator, receiver
AVA_RS19165	COG1741	Belongs to the pirin family
AVA_RS19170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AVA_RS19185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AVA_RS19215	COG0358	DNA primase activity
AVA_RS19225	COG0758	DNA mediated transformation
AVA_RS19225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AVA_RS19245	COG2226	methyltransferase
AVA_RS19250	COG0306	phosphate transporter
AVA_RS19280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AVA_RS19290	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AVA_RS19295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AVA_RS19320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AVA_RS19325	COG3536	Protein conserved in bacteria
AVA_RS19340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AVA_RS19345	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AVA_RS19355	COG0138	bifunctional purine biosynthesis protein purh
AVA_RS19370	COG3546	catalase activity
AVA_RS19375	COG2261	transglycosylase associated protein
AVA_RS19380	COG4232	protein-disulfide reductase activity
AVA_RS19385	COG1333	cytochrome c biogenesis protein
AVA_RS19400	COG5398	heme oxygenase
AVA_RS19405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVA_RS19425	COG2327	Polysaccharide pyruvyl transferase
AVA_RS19430	COG0617	tRNA 3'-terminal CCA addition
AVA_RS19440	COG1214	PFAM Peptidase M22, glycoprotease
AVA_RS19445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AVA_RS19475	COG0574	Belongs to the PEP-utilizing enzyme family
AVA_RS19475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVA_RS19495	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AVA_RS19505	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AVA_RS19510	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AVA_RS19515	COG5002	protein histidine kinase activity
AVA_RS19525	COG4251	negative regulation of phosphorylation
AVA_RS19530	COG0784	Response regulator, receiver
AVA_RS19535	COG2205	protein histidine kinase activity
AVA_RS19555	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVA_RS19560	COG2217	Heavy metal translocating P-type atpase
AVA_RS19565	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AVA_RS19580	COG0628	permease
AVA_RS19595	COG5002	protein histidine kinase activity
AVA_RS19605	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS19605	COG0515	serine threonine protein kinase
AVA_RS19640	COG0463	Glycosyl transferase, family 2
AVA_RS19640	COG1216	Glycosyl transferase, family 2
AVA_RS19650	COG0110	maltose O-acetyltransferase activity
AVA_RS19670	COG0357	Ribosomal RNA small subunit methyltransferase G
AVA_RS19675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AVA_RS19680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AVA_RS19685	COG0321	lipoyl(octanoyl) transferase activity
AVA_RS19700	COG0765	amino acid transport
AVA_RS19725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVA_RS19730	COG0457	Tetratricopeptide repeat
AVA_RS19735	COG2135	peptidase activity
AVA_RS19740	COG0625	glutathione transferase activity
AVA_RS19745	COG1872	DUF167
AVA_RS19760	COG5592	hemerythrin HHE cation binding domain
AVA_RS19765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AVA_RS19780	COG2363	Small membrane protein
AVA_RS19785	COG4451	ribulose bisphosphate carboxylase, small
AVA_RS19785	COG0464	growth
AVA_RS19795	COG4451	ribulose bisphosphate carboxylase, small
AVA_RS19805	COG1850	ribulose-bisphosphate carboxylase activity
AVA_RS19815	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AVA_RS19825	COG0531	amino acid
AVA_RS19840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AVA_RS19855	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AVA_RS19860	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS19885	COG2124	cytochrome p450
AVA_RS19895	COG4782	Protein conserved in bacteria
AVA_RS19905	COG4636	protein conserved in cyanobacteria
AVA_RS19920	COG0582	viral genome integration into host DNA
AVA_RS19925	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS19930	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS19935	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS19950	COG5420	small protein containing a coiled-coil domain
AVA_RS19960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVA_RS19965	COG0316	Belongs to the HesB IscA family
AVA_RS19970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AVA_RS20035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AVA_RS20040	COG1045	serine acetyltransferase
AVA_RS20055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVA_RS20060	COG5554	nitrogen fixation
AVA_RS20065	COG5554	nitrogen fixation
AVA_RS20090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AVA_RS20105	COG0066	3-isopropylmalate dehydratase activity
AVA_RS20110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AVA_RS20115	COG0300	oxidoreductase activity
AVA_RS20120	COG2264	protein methyltransferase activity
AVA_RS20150	COG5002	protein histidine kinase activity
AVA_RS20150	COG0784	Response regulator, receiver
AVA_RS20150	COG2198	Histidine kinase
AVA_RS20175	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AVA_RS20210	COG0318	PFAM AMP-dependent synthetase and ligase
AVA_RS20215	COG2986	histidine ammonia-lyase
AVA_RS20250	COG2815	serine threonine protein kinase
AVA_RS20250	COG0515	serine threonine protein kinase
AVA_RS20255	COG0737	Belongs to the 5'-nucleotidase family
AVA_RS20320	COG1404	Belongs to the peptidase S8 family
AVA_RS20320	COG4935	Belongs to the peptidase S8 family
AVA_RS20345	COG1940	carbohydrate kinase activity
AVA_RS20360	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AVA_RS20365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AVA_RS20370	COG0742	ribosomal rna small subunit methyltransferase
AVA_RS20375	COG2010	Cytochrome c
AVA_RS20390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVA_RS20395	COG0412	Dienelactone hydrolase
AVA_RS20420	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS20425	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS20460	COG0778	Nitroreductase
AVA_RS20475	COG1309	transcriptional regulator
AVA_RS20480	COG1122	ATPase activity
AVA_RS20495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AVA_RS20500	COG1910	domain protein
AVA_RS20525	COG1294	oxidase, subunit
AVA_RS20530	COG1271	oxidase subunit
AVA_RS20545	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS20580	COG3659	wide pore channel activity
AVA_RS20605	COG2124	cytochrome p450
AVA_RS20605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AVA_RS20615	COG0482	sulfurtransferase activity
AVA_RS20620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS20660	COG0489	protein tyrosine kinase activity
AVA_RS20670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AVA_RS20675	COG2873	o-acetylhomoserine
AVA_RS20680	COG2391	methyltransferase activity
AVA_RS20685	COG2897	thiosulfate sulfurtransferase activity
AVA_RS20705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AVA_RS20720	COG5002	protein histidine kinase activity
AVA_RS20755	COG1473	amidohydrolase
AVA_RS20760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AVA_RS20810	COG1136	(ABC) transporter
AVA_RS20815	COG0515	serine threonine protein kinase
AVA_RS20815	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS20825	COG0604	alcohol dehydrogenase
AVA_RS20825	COG3321	synthase
AVA_RS20835	COG2319	Wd-40 repeat
AVA_RS20835	COG4249	Peptidase C14 caspase catalytic subunit p20
AVA_RS20840	COG1881	PFAM PEBP family protein
AVA_RS20850	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AVA_RS20865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AVA_RS20905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AVA_RS20935	COG3540	Alkaline phosphatase
AVA_RS20960	COG0784	Response regulator, receiver
AVA_RS20960	COG2205	protein histidine kinase activity
AVA_RS20975	COG1116	anion transmembrane transporter activity
AVA_RS20980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVA_RS20985	COG3659	wide pore channel activity
AVA_RS20990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AVA_RS20995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVA_RS21010	COG0667	Aldo Keto reductase
AVA_RS21015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS21030	COG3706	GGDEF domain
AVA_RS21030	COG4251	negative regulation of phosphorylation
AVA_RS21030	COG2203	Gaf domain
AVA_RS21030	COG5001	Diguanylate cyclase
AVA_RS21045	COG0412	Dienelactone hydrolase
AVA_RS21050	COG0778	Nitroreductase
AVA_RS21055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS21060	COG0626	cystathionine gamma-synthase activity
AVA_RS21105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVA_RS21125	COG2442	InterPro IPR007367
AVA_RS21135	COG4804	nuclease activity
AVA_RS21195	COG2831	hemolysin activation secretion protein
AVA_RS21285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AVA_RS21300	COG0589	response to stress
AVA_RS21305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AVA_RS21310	COG0268	Binds directly to 16S ribosomal RNA
AVA_RS21315	COG0084	hydrolase, TatD family'
AVA_RS21325	COG0085	RNA polymerase activity
AVA_RS21330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVA_RS21335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AVA_RS21340	COG3239	Fatty acid desaturase
AVA_RS21345	COG3239	Fatty acid desaturase
AVA_RS21355	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AVA_RS21360	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
AVA_RS21370	COG0363	glucosamine-6-phosphate deaminase activity
AVA_RS21375	COG1716	ATPase activity
AVA_RS21385	COG2385	sporulation resulting in formation of a cellular spore
AVA_RS21405	COG0170	dolichyl monophosphate biosynthetic process
AVA_RS21410	COG1836	PFAM Integral membrane protein DUF92
AVA_RS21425	COG1404	Belongs to the peptidase S8 family
AVA_RS21435	COG2911	Protein conserved in bacteria
AVA_RS21435	COG1361	Conserved repeat domain
AVA_RS21435	COG3266	domain, Protein
AVA_RS21440	COG4636	protein conserved in cyanobacteria
AVA_RS21445	COG1131	(ABC) transporter
AVA_RS21465	COG0788	formyltetrahydrofolate deformylase activity
AVA_RS21470	COG2217	Heavy metal translocating P-type atpase
AVA_RS21480	COG0789	Transcriptional regulator
AVA_RS21485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AVA_RS21490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVA_RS21495	COG3119	arylsulfatase activity
AVA_RS21510	COG5554	nitrogen fixation
AVA_RS21515	COG0535	radical SAM domain protein
AVA_RS21515	COG1433	Dinitrogenase iron-molybdenum cofactor
AVA_RS21520	COG1104	cysteine desulfurase activity
AVA_RS21535	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AVA_RS21545	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS21550	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AVA_RS21565	COG5420	small protein containing a coiled-coil domain
AVA_RS21575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AVA_RS21580	COG0316	Belongs to the HesB IscA family
AVA_RS21585	COG0633	Ferredoxin
AVA_RS21590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AVA_RS21620	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AVA_RS21635	COG3706	GGDEF domain
AVA_RS21635	COG5001	Diguanylate cyclase
AVA_RS21635	COG2203	Gaf domain
AVA_RS21635	COG4251	negative regulation of phosphorylation
AVA_RS21640	COG0003	Pfam Anion-transporting ATPase
AVA_RS21680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AVA_RS21700	COG0121	glutamine amidotransferase
AVA_RS21705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVA_RS21710	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AVA_RS21725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AVA_RS21755	COG1619	proteins homologs of microcin C7 resistance protein MccF
AVA_RS21760	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AVA_RS21765	COG0415	Belongs to the DNA photolyase family
AVA_RS21780	COG0322	excinuclease ABC activity
AVA_RS21805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVA_RS21815	COG1845	cytochrome c oxidase, subunit III
AVA_RS21830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AVA_RS21850	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS21855	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AVA_RS21860	COG0612	Peptidase, M16
AVA_RS21865	COG0612	Peptidase, M16
AVA_RS21875	COG1950	PFAM Membrane protein of
AVA_RS21900	COG0702	epimerase
AVA_RS21910	COG0596	Alpha beta hydrolase
AVA_RS21920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AVA_RS21925	COG1937	Protein conserved in bacteria
AVA_RS21930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVA_RS21940	COG4191	Histidine kinase
AVA_RS21945	COG5002	protein histidine kinase activity
AVA_RS21970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVA_RS21975	COG0697	spore germination
AVA_RS21990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AVA_RS21995	COG4106	trans-aconitate 2-methyltransferase activity
AVA_RS22025	COG0752	glycyl-tRNA synthetase alpha subunit
AVA_RS22055	COG1132	(ABC) transporter
AVA_RS22065	COG0784	Response regulator, receiver
AVA_RS22070	COG4251	negative regulation of phosphorylation
AVA_RS22070	COG4251	negative regulation of phosphorylation
AVA_RS22075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AVA_RS22085	COG0542	response to heat
AVA_RS22095	COG0095	Lipoate-protein ligase
AVA_RS22115	COG1702	phosphate starvation-inducible protein PhoH
AVA_RS22120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AVA_RS22130	COG0228	four-way junction DNA binding
AVA_RS22135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AVA_RS22170	COG0006	proline dipeptidase activity
AVA_RS22175	COG0384	phenazine biosynthesis protein PhzF
AVA_RS22190	COG0612	Peptidase, M16
AVA_RS22195	COG0612	Peptidase, M16
AVA_RS22270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AVA_RS22275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AVA_RS22290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AVA_RS22310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AVA_RS22350	COG3852	Histidine kinase
AVA_RS22385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVA_RS22395	COG0505	Belongs to the CarA family
AVA_RS22410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AVA_RS22420	COG2267	carboxylic ester hydrolase activity
AVA_RS22425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AVA_RS22455	COG1741	Belongs to the pirin family
AVA_RS22460	COG0783	Belongs to the Dps family
AVA_RS22465	COG1773	rubredoxin
AVA_RS22475	COG2831	hemolysin activation secretion protein
AVA_RS22480	COG2130	NADP-dependent
AVA_RS22485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AVA_RS22485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AVA_RS22500	COG0745	RESPONSE REGULATOR receiver
AVA_RS22505	COG5002	protein histidine kinase activity
AVA_RS22510	COG3852	Histidine kinase
AVA_RS22515	COG1902	pentaerythritol trinitrate reductase activity
AVA_RS22535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AVA_RS22540	COG0640	Transcriptional regulator
AVA_RS22545	COG1121	(ABC) transporter
AVA_RS22550	COG0803	Belongs to the bacterial solute-binding protein 9 family
AVA_RS22555	COG3659	wide pore channel activity
AVA_RS22570	COG0123	including yeast histone deacetylase and acetoin utilization protein
AVA_RS22590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AVA_RS22595	COG0193	aminoacyl-tRNA hydrolase activity
AVA_RS22600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AVA_RS22630	COG2267	carboxylic ester hydrolase activity
AVA_RS22645	COG2202	Pas domain
AVA_RS22645	COG2205	protein histidine kinase activity
AVA_RS22675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AVA_RS22680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AVA_RS22690	COG0583	DNA-binding transcription factor activity
AVA_RS22695	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AVA_RS22700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AVA_RS22705	COG4451	ribulose bisphosphate carboxylase, small
AVA_RS22705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AVA_RS22710	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
AVA_RS22715	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AVA_RS22720	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AVA_RS22725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AVA_RS22730	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS22745	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AVA_RS22760	COG1254	Belongs to the acylphosphatase family
AVA_RS22775	COG0339	signal peptide processing
AVA_RS22785	COG0589	response to stress
AVA_RS22800	COG2815	serine threonine protein kinase
AVA_RS22800	COG0515	serine threonine protein kinase
AVA_RS22810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AVA_RS22835	COG0693	protein deglycase activity
AVA_RS22875	COG0515	serine threonine protein kinase
AVA_RS22875	COG2815	serine threonine protein kinase
AVA_RS22885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVA_RS22885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVA_RS22890	COG2897	thiosulfate sulfurtransferase activity
AVA_RS22895	COG4804	nuclease activity
AVA_RS22900	COG1160	GTP binding
AVA_RS22910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AVA_RS22915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVA_RS22920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AVA_RS22925	COG0581	inorganic phosphate transmembrane transporter activity
AVA_RS22930	COG0573	inorganic phosphate transmembrane transporter activity
AVA_RS22935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AVA_RS22940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AVA_RS22945	COG2197	response regulator
AVA_RS22975	COG0154	amidase activity
AVA_RS23010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AVA_RS23025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AVA_RS23030	COG0583	DNA-binding transcription factor activity
AVA_RS23035	COG3659	wide pore channel activity
AVA_RS23055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS23060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AVA_RS23065	COG1116	anion transmembrane transporter activity
AVA_RS23065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS23070	COG1116	anion transmembrane transporter activity
AVA_RS23075	COG0243	molybdopterin cofactor binding
AVA_RS23125	COG4106	trans-aconitate 2-methyltransferase activity
AVA_RS23135	COG0247	lactate metabolic process
AVA_RS23140	COG0277	FAD linked oxidase domain protein
AVA_RS23200	COG0589	response to stress
AVA_RS23205	COG0574	Belongs to the PEP-utilizing enzyme family
AVA_RS23205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AVA_RS23220	COG1132	(ABC) transporter
AVA_RS23230	COG0811	peptide transport
AVA_RS23235	COG0848	biopolymer transport protein
AVA_RS23265	COG0408	coproporphyrinogen oxidase activity
AVA_RS23275	COG0489	protein tyrosine kinase activity
AVA_RS23280	COG0772	Belongs to the SEDS family
AVA_RS23295	COG0589	response to stress
AVA_RS23295	COG0475	glutathione-regulated potassium exporter activity
AVA_RS23300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AVA_RS23305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AVA_RS23310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AVA_RS23375	COG0409	Hydrogenase expression formation protein
AVA_RS23390	COG0375	protein maturation
AVA_RS23395	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AVA_RS23405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVA_RS23410	COG0730	response to heat
AVA_RS23435	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AVA_RS23455	COG0768	penicillin binding
AVA_RS23480	COG0012	GTP binding
AVA_RS23500	COG0363	glucosamine-6-phosphate deaminase activity
AVA_RS23505	COG0546	phosphoglycolate phosphatase activity
AVA_RS23510	COG0784	Response regulator, receiver
AVA_RS23510	COG5002	protein histidine kinase activity
AVA_RS23515	COG0731	radical SAM domain protein
AVA_RS23525	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AVA_RS23530	COG0830	nickel cation binding
AVA_RS23535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AVA_RS23540	COG0492	ferredoxin-NADP+ reductase activity
AVA_RS23545	COG1175	transmembrane transport
AVA_RS23555	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AVA_RS23565	COG0330	HflC and HflK could
AVA_RS23570	COG0724	RNA recognition motif
AVA_RS23575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AVA_RS23580	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AVA_RS23605	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AVA_RS23615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AVA_RS23620	COG0589	response to stress
AVA_RS23645	COG1034	ATP synthesis coupled electron transport
AVA_RS23655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AVA_RS23665	COG3259	Nickel-dependent hydrogenase
AVA_RS23680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AVA_RS23680	COG0045	succinate-CoA ligase (ADP-forming) activity
AVA_RS23680	COG1042	CoA-binding domain protein
AVA_RS23690	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AVA_RS23695	COG4221	oxidoreductase activity
AVA_RS23700	COG2226	methyltransferase
AVA_RS23710	COG0745	RESPONSE REGULATOR receiver
AVA_RS23715	COG1657	PFAM Prenyltransferase squalene oxidase
AVA_RS23735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AVA_RS23750	COG3237	CsbD-like
AVA_RS23760	COG0556	nucleotide-excision repair
AVA_RS23800	COG1196	nuclear chromosome segregation
AVA_RS23805	COG1252	NADH dehydrogenase
AVA_RS23810	COG1252	NADH dehydrogenase
AVA_RS23820	COG0625	glutathione transferase activity
AVA_RS23825	COG3631	Ketosteroid isomerase-related protein
AVA_RS23830	COG0589	response to stress
AVA_RS23835	COG2205	protein histidine kinase activity
AVA_RS23835	COG0784	Response regulator, receiver
AVA_RS23850	COG0438	transferase activity, transferring glycosyl groups
AVA_RS23860	COG0784	Response regulator, receiver
AVA_RS23860	COG5002	protein histidine kinase activity
AVA_RS23885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AVA_RS23895	COG2267	carboxylic ester hydrolase activity
AVA_RS23900	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AVA_RS23905	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AVA_RS23915	COG4208	sulfate ABC transporter
AVA_RS23920	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AVA_RS23925	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AVA_RS23930	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AVA_RS23955	COG0121	glutamine amidotransferase
AVA_RS23960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVA_RS23970	COG5002	protein histidine kinase activity
AVA_RS23990	COG0584	glycerophosphoryl diester phosphodiesterase
AVA_RS24025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AVA_RS24050	COG2207	Transcriptional regulator
AVA_RS24055	COG4221	oxidoreductase activity
AVA_RS24055	COG3321	synthase
AVA_RS24055	COG0300	oxidoreductase activity
AVA_RS24055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVA_RS24075	COG3321	synthase
AVA_RS24075	COG0604	alcohol dehydrogenase
AVA_RS24090	COG0604	alcohol dehydrogenase
AVA_RS24090	COG3321	synthase
AVA_RS24110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AVA_RS24110	COG2070	2-Nitropropane dioxygenase
AVA_RS24125	COG0314	molybdopterin synthase activity
AVA_RS24150	COG0778	Nitroreductase
AVA_RS24155	COG1902	pentaerythritol trinitrate reductase activity
AVA_RS24160	COG3118	belongs to the thioredoxin family
AVA_RS24165	COG0640	Transcriptional regulator
AVA_RS24175	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS24175	COG0515	serine threonine protein kinase
AVA_RS24215	COG1803	Methylglyoxal synthase
AVA_RS24215	COG1597	lipid kinase activity
AVA_RS24225	COG0181	hydroxymethylbilane synthase activity
AVA_RS24230	COG0297	glycogen (starch) synthase activity
AVA_RS24235	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AVA_RS24250	COG3850	Histidine kinase
AVA_RS24250	COG3437	response regulator, receiver
AVA_RS24250	COG2205	protein histidine kinase activity
AVA_RS24250	COG4999	Histidine kinase
AVA_RS24255	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS24260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AVA_RS24270	COG5002	protein histidine kinase activity
AVA_RS24270	COG0784	Response regulator, receiver
AVA_RS24275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AVA_RS24280	COG1994	Peptidase M50
AVA_RS24280	COG0517	IMP dehydrogenase activity
AVA_RS24285	COG1006	Multisubunit Na H antiporter MnhC subunit
AVA_RS24290	COG0651	ATP synthesis coupled electron transport
AVA_RS24335	COG1562	ergosterol biosynthetic process
AVA_RS24340	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AVA_RS24340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AVA_RS24365	COG0792	nuclease activity
AVA_RS24375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AVA_RS24385	COG0569	domain protein
AVA_RS24390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AVA_RS24395	COG2226	methyltransferase
AVA_RS24400	COG2205	protein histidine kinase activity
AVA_RS24400	COG0784	Response regulator, receiver
AVA_RS24430	COG1672	PFAM Archaeal ATPase
AVA_RS24430	COG2319	Wd-40 repeat
AVA_RS24445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AVA_RS24475	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AVA_RS24485	COG4636	protein conserved in cyanobacteria
AVA_RS24500	COG3842	ATPase activity
AVA_RS24505	COG0515	serine threonine protein kinase
AVA_RS24510	COG0538	isocitrate dehydrogenase activity
AVA_RS24520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AVA_RS24560	COG1442	glycosyl transferase family 8
AVA_RS24560	COG1216	Glycosyl transferase, family 2
AVA_RS24565	COG0438	transferase activity, transferring glycosyl groups
AVA_RS24570	COG3307	-O-antigen
AVA_RS24575	COG0438	transferase activity, transferring glycosyl groups
AVA_RS24580	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AVA_RS24595	COG1472	Belongs to the glycosyl hydrolase 3 family
AVA_RS24635	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS24635	COG0515	serine threonine protein kinase
AVA_RS24640	COG1104	cysteine desulfurase activity
AVA_RS24645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AVA_RS24650	COG3265	gluconokinase activity
AVA_RS24655	COG1489	DNA binding
AVA_RS24665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AVA_RS24675	COG0515	serine threonine protein kinase
AVA_RS24680	COG0515	serine threonine protein kinase
AVA_RS24695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AVA_RS24710	COG2337	Toxic component of a toxin-antitoxin (TA) module
AVA_RS24735	COG0432	Pfam Uncharacterised protein family UPF0047
AVA_RS24745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AVA_RS24760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AVA_RS24790	COG0582	viral genome integration into host DNA
AVA_RS24800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AVA_RS24805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AVA_RS24820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AVA_RS24820	COG0512	Glutamine amidotransferase of anthranilate synthase
AVA_RS24830	COG0134	indole-3-glycerol-phosphate synthase activity
AVA_RS24845	COG0784	Response regulator, receiver
AVA_RS24850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVA_RS24860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AVA_RS24865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AVA_RS24895	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS24900	COG2501	S4 domain
AVA_RS24920	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AVA_RS24935	COG0745	RESPONSE REGULATOR receiver
AVA_RS24950	COG0140	phosphoribosyl-ATP diphosphatase activity
AVA_RS24950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AVA_RS24960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AVA_RS24975	COG0515	serine threonine protein kinase
AVA_RS24975	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS24985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AVA_RS24990	COG1619	proteins homologs of microcin C7 resistance protein MccF
AVA_RS24995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AVA_RS25005	COG1196	nuclear chromosome segregation
AVA_RS25005	COG0741	lytic transglycosylase activity
AVA_RS25005	COG0739	heme binding
AVA_RS25015	COG1376	ErfK ybiS ycfS ynhG family protein
AVA_RS25020	COG1595	DNA-templated transcription, initiation
AVA_RS25035	COG0495	leucyl-tRNA aminoacylation
AVA_RS25040	COG0590	tRNA wobble adenosine to inosine editing
AVA_RS25115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AVA_RS25120	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AVA_RS25145	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AVA_RS25195	COG4771	TonB-dependent receptor
AVA_RS25250	COG0697	spore germination
AVA_RS25265	COG0678	peroxiredoxin activity
AVA_RS25265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AVA_RS25275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AVA_RS25295	COG1122	ATPase activity
AVA_RS25305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AVA_RS25325	COG4172	Belongs to the ABC transporter superfamily
AVA_RS25330	COG1252	NADH dehydrogenase
AVA_RS25335	COG1132	(ABC) transporter
AVA_RS25350	COG0408	coproporphyrinogen oxidase activity
AVA_RS25360	COG0625	glutathione transferase activity
AVA_RS25370	COG0644	oxidoreductase
AVA_RS25385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS25390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS25420	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
AVA_RS25425	COG0667	Aldo Keto reductase
AVA_RS25430	COG0625	glutathione transferase activity
AVA_RS25440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AVA_RS25460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AVA_RS25465	COG1045	serine acetyltransferase
AVA_RS25470	COG1959	2 iron, 2 sulfur cluster binding
AVA_RS25475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AVA_RS25500	COG0583	DNA-binding transcription factor activity
AVA_RS25510	COG0730	response to heat
AVA_RS25515	COG0671	phosphoesterase, PA-phosphatase related
AVA_RS25525	COG0330	HflC and HflK could
AVA_RS25540	COG2319	Wd-40 repeat
AVA_RS25540	COG3903	Transcriptional regulator
AVA_RS25545	COG1335	isochorismatase
AVA_RS25550	COG3224	Antibiotic biosynthesis monooxygenase
AVA_RS25565	COG2022	thiamine diphosphate biosynthetic process
AVA_RS25565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AVA_RS25595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AVA_RS25600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AVA_RS25620	COG0352	thiamine-phosphate diphosphorylase activity
AVA_RS25660	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS25660	COG0515	serine threonine protein kinase
AVA_RS25665	COG1177	transmembrane transport
AVA_RS25675	COG0438	transferase activity, transferring glycosyl groups
AVA_RS25680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AVA_RS25690	COG2095	MarC family integral membrane protein
AVA_RS25710	COG2217	Heavy metal translocating P-type atpase
AVA_RS25725	COG0242	peptide deformylase activity
AVA_RS25730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AVA_RS25820	COG0776	regulation of translation
AVA_RS25860	COG1191	sigma factor activity
AVA_RS25880	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AVA_RS26005	COG0582	viral genome integration into host DNA
AVA_RS26050	COG0515	serine threonine protein kinase
AVA_RS26050	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS26055	COG2319	Wd-40 repeat
AVA_RS26055	COG3903	Transcriptional regulator
AVA_RS26150	COG2205	protein histidine kinase activity
AVA_RS26155	COG2197	response regulator
AVA_RS26190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVA_RS26310	COG0129	dihydroxy-acid dehydratase activity
AVA_RS26340	COG0583	DNA-binding transcription factor activity
AVA_RS26345	COG1061	Type III restriction enzyme res subunit
AVA_RS26455	COG1715	Restriction endonuclease
AVA_RS26520	COG0659	secondary active sulfate transmembrane transporter activity
AVA_RS26530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AVA_RS26560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AVA_RS26665	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
AVA_RS26675	COG4245	von Willebrand factor, type A
AVA_RS26715	COG4974	Belongs to the 'phage' integrase family
AVA_RS26725	COG1858	cytochrome C peroxidase
AVA_RS26755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AVA_RS26760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVA_RS26765	COG1120	ATPase activity
AVA_RS26815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AVA_RS26820	COG1120	ATPase activity
AVA_RS26830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AVA_RS26835	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AVA_RS26850	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AVA_RS26865	COG1271	oxidase subunit
AVA_RS26870	COG1294	oxidase, subunit
AVA_RS26880	COG1271	oxidase subunit
AVA_RS26890	COG1845	cytochrome c oxidase, subunit III
AVA_RS26900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AVA_RS26930	COG4771	TonB-dependent receptor
AVA_RS26950	COG4974	Belongs to the 'phage' integrase family
AVA_RS26955	COG2205	protein histidine kinase activity
AVA_RS26960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AVA_RS26960	COG2205	protein histidine kinase activity
AVA_RS26990	COG2205	protein histidine kinase activity
AVA_RS27005	COG3659	wide pore channel activity
AVA_RS27015	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS27015	COG0515	serine threonine protein kinase
AVA_RS27025	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AVA_RS27035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AVA_RS27040	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AVA_RS27045	COG5002	protein histidine kinase activity
AVA_RS27050	COG2197	response regulator
AVA_RS27080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVA_RS27125	COG1121	(ABC) transporter
AVA_RS27130	COG0803	Belongs to the bacterial solute-binding protein 9 family
AVA_RS27130	COG3443	Belongs to the bacterial solute-binding protein 9 family
AVA_RS27135	COG0113	porphobilinogen synthase activity
AVA_RS27140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AVA_RS27150	COG0523	cobalamin synthesis protein
AVA_RS27155	COG2226	methyltransferase
AVA_RS27215	COG3659	wide pore channel activity
AVA_RS27235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AVA_RS27415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVA_RS27415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVA_RS27475	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AVA_RS27540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AVA_RS27545	COG1061	Type III restriction enzyme res subunit
AVA_RS27660	COG1372	Participates in initiation and elongation during chromosome replication
AVA_RS27660	COG0305	Participates in initiation and elongation during chromosome replication
AVA_RS27770	COG0631	protein serine/threonine phosphatase activity
AVA_RS27805	COG3266	domain, Protein
AVA_RS27805	COG0515	serine threonine protein kinase
AVA_RS27865	COG1475	DNA binding
AVA_RS27870	COG1192	Involved in chromosome partitioning
AVA_RS27905	COG0305	Participates in initiation and elongation during chromosome replication
AVA_RS27905	COG0305	Participates in initiation and elongation during chromosome replication
AVA_RS27905	COG1372	Participates in initiation and elongation during chromosome replication
AVA_RS27905	COG1372	Participates in initiation and elongation during chromosome replication
AVA_RS27935	COG5285	phytanoyl-CoA dioxygenase
AVA_RS27980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AVA_RS28035	COG3659	wide pore channel activity
AVA_RS28040	COG2814	Major facilitator Superfamily
AVA_RS28045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AVA_RS28055	COG2207	Transcriptional regulator
AVA_RS28070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AVA_RS28220	COG1205	dead DEAH box helicase
AVA_RS28220	COG1111	helicase
AVA_RS28300	COG0592	DNA-directed DNA polymerase activity
AVA_RS28305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AVA_RS28345	COG0470	DNA polymerase III
AVA_RS28360	COG3335	DDE superfamily endonuclease
AVA_RS28375	COG0776	regulation of translation
AVA_RS28420	COG1266	CAAX protease self-immunity
AVA_RS28455	COG1335	isochorismatase
AVA_RS28460	COG2267	carboxylic ester hydrolase activity
AVA_RS28465	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS28465	COG3321	synthase
AVA_RS28465	COG0604	alcohol dehydrogenase
AVA_RS28475	COG1028	Short-chain dehydrogenase reductase Sdr
AVA_RS28490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVA_RS28490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVA_RS28495	COG4221	oxidoreductase activity
AVA_RS28510	COG2207	Transcriptional regulator
AVA_RS28515	COG2197	response regulator
AVA_RS28520	COG2815	serine threonine protein kinase
AVA_RS28520	COG0515	serine threonine protein kinase
AVA_RS28540	COG1192	Involved in chromosome partitioning
AVA_RS28550	COG1475	DNA binding
AVA_RS28555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AVA_RS28560	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AVA_RS28565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AVA_RS28570	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AVA_RS28575	COG2080	2 iron, 2 sulfur cluster binding
AVA_RS28595	COG0542	response to heat
AVA_RS28605	COG0484	heat shock protein binding
AVA_RS28625	COG0656	L-ascorbic acid biosynthetic process
AVA_RS28635	COG4572	Cation transport regulator
AVA_RS28640	COG0443	Heat shock 70 kDa protein
AVA_RS28645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AVA_RS28645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AVA_RS28660	COG0459	protein refolding
AVA_RS28665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AVA_RS28675	COG1902	pentaerythritol trinitrate reductase activity
AVA_RS28690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AVA_RS28710	COG2205	protein histidine kinase activity
AVA_RS28735	COG0745	RESPONSE REGULATOR receiver
AVA_RS28745	COG0716	FMN binding
AVA_RS28895	COG2197	response regulator
AVA_RS28975	COG0739	heme binding
AVA_RS29090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AVA_RS29190	COG2198	Histidine kinase
AVA_RS29190	COG0784	Response regulator, receiver
AVA_RS29190	COG0643	Histidine kinase
AVA_RS29215	COG3920	Histidine kinase
AVA_RS29215	COG2202	Pas domain
AVA_RS29220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AVA_RS29285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AVA_RS29355	COG2205	protein histidine kinase activity
AVA_RS29355	COG2202	Pas domain
AVA_RS29440	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AVA_RS29445	COG4249	Peptidase C14 caspase catalytic subunit p20
AVA_RS29445	COG2319	Wd-40 repeat
AVA_RS29485	COG3266	domain, Protein
AVA_RS29485	COG0515	serine threonine protein kinase
AVA_RS29535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AVA_RS29550	COG1357	PFAM Pentapeptide repeats (8 copies)
AVA_RS29550	COG0515	serine threonine protein kinase
AVA_RS29625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AVA_RS29625	COG0515	serine threonine protein kinase
AVA_RS29675	COG0732	type I restriction modification DNA specificity domain
AVA_RS29720	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AVA_RS29855	COG1615	UPF0182 protein
AVA_RS29865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane