locus-tag	class	description
K529_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K529_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K529_RS00040	COG2003	Belongs to the UPF0758 family
K529_RS00045	COG0484	heat shock protein binding
K529_RS00050	COG0443	Heat shock 70 kDa protein
K529_RS00070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K529_RS00080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K529_RS00105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K529_RS00110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K529_RS00115	COG1137	ATPase activity
K529_RS00120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K529_RS00140	COG4774	siderophore transport
K529_RS00145	COG0569	domain protein
K529_RS00150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K529_RS00160	COG1070	Carbohydrate kinase
K529_RS00165	COG2115	Belongs to the xylose isomerase family
K529_RS00175	COG1858	cytochrome C peroxidase
K529_RS00180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K529_RS00195	COG3263	regulation of cellular component size
K529_RS00200	COG4608	Belongs to the ABC transporter superfamily
K529_RS00205	COG0444	Belongs to the ABC transporter superfamily
K529_RS00210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS00215	COG0601	transmembrane transport
K529_RS00220	COG0747	negative chemotaxis
K529_RS00230	COG1522	sequence-specific DNA binding
K529_RS00240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K529_RS00250	COG1953	Uracil, thiamine, allantoin
K529_RS00255	COG1132	(ABC) transporter
K529_RS00260	COG2081	HI0933 family
K529_RS00265	COG0625	glutathione transferase activity
K529_RS00280	COG0495	leucyl-tRNA aminoacylation
K529_RS00295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K529_RS00310	COG0745	RESPONSE REGULATOR receiver
K529_RS00325	COG3118	belongs to the thioredoxin family
K529_RS00330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K529_RS00335	COG2835	tetraacyldisaccharide 4'-kinase activity
K529_RS00340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K529_RS00345	COG0154	amidase activity
K529_RS00355	COG1674	ftsk spoiiie
K529_RS00375	COG0405	Gamma-glutamyltransferase
K529_RS00380	COG2172	sigma factor antagonist activity
K529_RS00390	COG0183	Belongs to the thiolase family
K529_RS00395	COG1956	GAF domain-containing protein
K529_RS00425	COG0564	pseudouridine synthase activity
K529_RS00440	COG0450	alkyl hydroperoxide reductase
K529_RS00450	COG1185	polyribonucleotide nucleotidyltransferase activity
K529_RS00460	COG0523	cobalamin synthesis protein
K529_RS00465	COG1629	transport
K529_RS00470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K529_RS00475	COG0596	Alpha beta hydrolase
K529_RS00490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K529_RS00500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K529_RS00505	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K529_RS00525	COG0138	bifunctional purine biosynthesis protein purh
K529_RS00530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K529_RS00540	COG0612	Peptidase, M16
K529_RS00545	COG0612	Peptidase, M16
K529_RS00550	COG1012	belongs to the aldehyde dehydrogenase family
K529_RS00560	COG0803	Belongs to the bacterial solute-binding protein 9 family
K529_RS00565	COG1121	(ABC) transporter
K529_RS00570	COG1321	iron dependent repressor
K529_RS00570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K529_RS00575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K529_RS00610	COG0625	glutathione transferase activity
K529_RS00625	COG0745	RESPONSE REGULATOR receiver
K529_RS00675	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K529_RS00680	COG1178	ABC-type Fe3 transport system permease component
K529_RS00690	COG1840	ABC-type Fe3 transport system, periplasmic component
K529_RS00695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K529_RS00710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K529_RS00720	COG0284	orotidine-5'-phosphate decarboxylase activity
K529_RS00730	COG0069	glutamate synthase activity
K529_RS00735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K529_RS00740	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K529_RS00775	COG1250	3-hydroxyacyl-CoA dehydrogenase
K529_RS00810	COG0300	oxidoreductase activity
K529_RS00820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K529_RS00830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K529_RS00850	COG0250	Participates in transcription elongation, termination and antitermination
K529_RS00860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K529_RS00865	COG0081	regulation of translation
K529_RS00875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K529_RS00880	COG0222	ribosome binding
K529_RS00885	COG0085	RNA polymerase activity
K529_RS00890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K529_RS00900	COG0697	spore germination
K529_RS00910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K529_RS00915	COG0049	tRNA binding
K529_RS00920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K529_RS00925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K529_RS00930	COG0656	L-ascorbic acid biosynthetic process
K529_RS00950	COG0051	transcription antitermination factor activity, RNA binding
K529_RS00955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K529_RS00960	COG0088	Forms part of the polypeptide exit tunnel
K529_RS00965	COG0089	rRNA binding
K529_RS00980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K529_RS00985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K529_RS00990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K529_RS00995	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K529_RS01000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K529_RS01005	COG0625	glutathione transferase activity
K529_RS01035	COG0255	Belongs to the universal ribosomal protein uL29 family
K529_RS01040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K529_RS01045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K529_RS01050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K529_RS01055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K529_RS01060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K529_RS01065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K529_RS01070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K529_RS01075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K529_RS01080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K529_RS01085	COG1841	ribosomal large subunit assembly
K529_RS01105	COG0200	Binds to the 23S rRNA
K529_RS01110	COG0201	protein transport
K529_RS01115	COG0563	adenylate kinase activity
K529_RS01120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K529_RS01125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K529_RS01130	COG0202	RNA polymerase activity
K529_RS01135	COG0203	ribosomal protein L17
K529_RS01140	COG2824	Alkylphosphonate utilization operon protein PhnA
K529_RS01145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K529_RS01160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K529_RS01170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K529_RS01175	COG2132	Multicopper oxidase
K529_RS01180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K529_RS01185	COG0564	pseudouridine synthase activity
K529_RS01200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K529_RS01205	COG4597	amino acid ABC transporter
K529_RS01210	COG0765	amino acid transport
K529_RS01215	COG1126	abc transporter atp-binding protein
K529_RS01235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K529_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS01255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K529_RS01265	COG0706	membrane insertase activity
K529_RS01275	COG0037	tRNA processing
K529_RS01285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K529_RS01290	COG0594	ribonuclease P activity
K529_RS01295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K529_RS01300	COG0398	Pfam SNARE associated Golgi protein
K529_RS01310	COG3852	Histidine kinase
K529_RS01315	COG1802	Transcriptional regulator
K529_RS01330	COG4650	regulator
K529_RS01360	COG0714	Associated with various cellular activities
K529_RS01375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K529_RS01380	COG2011	ABC-type metal ion transport system permease component
K529_RS01385	COG1464	Belongs to the NlpA lipoprotein family
K529_RS01390	COG1309	transcriptional regulator
K529_RS01405	COG0778	Nitroreductase
K529_RS01405	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
K529_RS01410	COG1920	GTP binding
K529_RS01415	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K529_RS01420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K529_RS01425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K529_RS01435	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K529_RS01450	COG1953	Uracil, thiamine, allantoin
K529_RS01475	COG0784	Response regulator, receiver
K529_RS01475	COG2205	protein histidine kinase activity
K529_RS01480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K529_RS01485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_RS01490	COG4558	Periplasmic binding protein
K529_RS01495	COG3720	iron ion transport
K529_RS01510	COG0811	peptide transport
K529_RS01515	COG0848	biopolymer transport protein
K529_RS01540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_RS01560	COG0840	transmembrane signaling receptor activity
K529_RS01565	COG1024	Enoyl-CoA hydratase
K529_RS01565	COG1250	3-hydroxyacyl-CoA dehydrogenase
K529_RS01570	COG0183	Belongs to the thiolase family
K529_RS01585	COG0837	glucose binding
K529_RS01600	COG0730	response to heat
K529_RS01625	COG1072	(Pantothenic acid kinase))
K529_RS01650	COG0800	Aldolase
K529_RS01655	COG0129	dihydroxy-acid dehydratase activity
K529_RS01660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K529_RS01665	COG0166	Belongs to the GPI family
K529_RS01670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
K529_RS01675	COG0830	nickel cation binding
K529_RS01680	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
K529_RS01690	COG0804	urea catabolic process
K529_RS01695	COG0832	Belongs to the urease beta subunit family
K529_RS01705	COG0831	urea catabolic process
K529_RS01710	COG0829	nickel cation binding
K529_RS01715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_RS01725	COG2936	dipeptidyl-peptidase activity
K529_RS01745	COG0489	protein tyrosine kinase activity
K529_RS01775	COG0243	molybdopterin cofactor binding
K529_RS01775	COG3383	formate dehydrogenase (NAD+) activity
K529_RS01780	COG0437	4 iron, 4 sulfur cluster binding
K529_RS01785	COG2864	formate dehydrogenase
K529_RS01795	COG2204	response regulator
K529_RS01800	COG3852	Histidine kinase
K529_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS01810	COG0300	oxidoreductase activity
K529_RS01830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K529_RS01840	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K529_RS01845	COG1595	DNA-templated transcription, initiation
K529_RS01850	COG3806	Anti-sigma factor
K529_RS01865	COG3811	Belongs to the UPF0386 family
K529_RS01875	COG1215	transferase activity, transferring glycosyl groups
K529_RS01885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K529_RS01890	COG0179	Fumarylacetoacetate (FAA) hydrolase
K529_RS01920	COG1175	transmembrane transport
K529_RS01935	COG0840	transmembrane signaling receptor activity
K529_RS01955	COG2030	dehydratase
K529_RS01955	COG1012	belongs to the aldehyde dehydrogenase family
K529_RS01960	COG1024	Enoyl-CoA hydratase
K529_RS01965	COG2050	protein possibly involved in aromatic compounds catabolism
K529_RS01985	COG2885	chlorophyll binding
K529_RS01990	COG0180	Tryptophanyl-tRNA synthetase
K529_RS02005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K529_RS02015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K529_RS02020	COG0792	nuclease activity
K529_RS02035	COG0606	chelatase, subunit chli
K529_RS02065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K529_RS02085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K529_RS02090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K529_RS02095	COG0765	amino acid transport
K529_RS02105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K529_RS02115	COG0583	DNA-binding transcription factor activity
K529_RS02120	COG0772	Belongs to the SEDS family
K529_RS02125	COG0768	penicillin binding
K529_RS02150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K529_RS02155	COG0840	transmembrane signaling receptor activity
K529_RS02155	COG0840	transmembrane signaling receptor activity
K529_RS02180	COG0405	Gamma-glutamyltransferase
K529_RS02185	COG0277	FAD linked oxidase domain protein
K529_RS02220	COG0667	Aldo Keto reductase
K529_RS02225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K529_RS02235	COG1079	Belongs to the binding-protein-dependent transport system permease family
K529_RS02240	COG4603	Belongs to the binding-protein-dependent transport system permease family
K529_RS02245	COG3845	ABC transporter
K529_RS02255	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K529_RS02265	COG0659	secondary active sulfate transmembrane transporter activity
K529_RS02275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K529_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS02305	COG0698	ribose 5-phosphate isomerase
K529_RS02315	COG0752	glycyl-tRNA synthetase alpha subunit
K529_RS02325	COG0751	glycine-tRNA ligase activity
K529_RS02330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K529_RS02330	COG0574	Belongs to the PEP-utilizing enzyme family
K529_RS02340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K529_RS02345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K529_RS02350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K529_RS02360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K529_RS02365	COG1522	sequence-specific DNA binding
K529_RS02370	COG1522	sequence-specific DNA binding
K529_RS02395	COG1802	Transcriptional regulator
K529_RS02400	COG1215	transferase activity, transferring glycosyl groups
K529_RS02405	COG0505	Belongs to the CarA family
K529_RS02410	COG1610	YqeY-like protein
K529_RS02425	COG0537	adenosine 5'-monophosphoramidase activity
K529_RS02430	COG0346	lactoylglutathione lyase activity
K529_RS02435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K529_RS02440	COG3046	protein related to deoxyribodipyrimidine photolyase
K529_RS02460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_RS02470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K529_RS02485	COG1959	2 iron, 2 sulfur cluster binding
K529_RS02495	COG4181	ATPase activity
K529_RS02550	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K529_RS02565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K529_RS02595	COG4136	ATPase activity
K529_RS02600	COG4135	transport system, permease component
K529_RS02605	COG4134	Bacterial extracellular solute-binding protein
K529_RS02610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K529_RS02615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K529_RS02625	COG0583	DNA-binding transcription factor activity
K529_RS02635	COG0625	glutathione transferase activity
K529_RS02660	COG1024	Enoyl-CoA hydratase
K529_RS02665	COG1960	acyl-CoA dehydrogenase activity
K529_RS02690	COG0411	ABC transporter
K529_RS02730	COG3483	tryptophan 2,3-dioxygenase activity
K529_RS02760	COG1648	precorrin-2 dehydrogenase activity
K529_RS02760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K529_RS02765	COG1797	cobyrinic acid a,c-diamide synthase activity
K529_RS02770	COG2875	Belongs to the precorrin methyltransferase family
K529_RS02785	COG2099	Precorrin-6x reductase
K529_RS02890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K529_RS02900	COG2268	Band 7 protein
K529_RS02920	COG0667	Aldo Keto reductase
K529_RS02930	COG3246	L-lysine catabolic process to acetate
K529_RS02935	COG3040	lipid binding
K529_RS02940	COG0824	Thioesterase
K529_RS02940	COG1250	3-hydroxyacyl-CoA dehydrogenase
K529_RS02980	COG1595	DNA-templated transcription, initiation
K529_RS02995	COG3706	GGDEF domain
K529_RS03020	COG5002	protein histidine kinase activity
K529_RS03020	COG5001	Diguanylate cyclase
K529_RS03020	COG3447	MASE1 domain protein
K529_RS03030	COG0243	molybdopterin cofactor binding
K529_RS03050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K529_RS03055	COG1494	fructose-1,6-bisphosphatase
K529_RS03080	COG1741	Belongs to the pirin family
K529_RS03085	COG2223	nitrite transmembrane transporter activity
K529_RS03095	COG1757	Na H antiporter
K529_RS03100	COG2423	ornithine cyclodeaminase activity
K529_RS03110	COG1396	sequence-specific DNA binding
K529_RS03150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K529_RS03165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_RS03175	COG0446	pyridine nucleotide-disulphide oxidoreductase
K529_RS03175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K529_RS03190	COG0358	DNA primase activity
K529_RS03195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K529_RS03215	COG0432	Pfam Uncharacterised protein family UPF0047
K529_RS03220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K529_RS03225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K529_RS03225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K529_RS03260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K529_RS03265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K529_RS03275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K529_RS03310	COG0564	pseudouridine synthase activity
K529_RS03325	COG1414	Transcriptional regulator
K529_RS03330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_RS03350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K529_RS03365	COG1522	sequence-specific DNA binding
K529_RS03375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K529_RS03380	COG0287	Prephenate dehydrogenase
K529_RS03395	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
K529_RS03425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K529_RS03435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K529_RS03440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K529_RS03445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K529_RS03450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K529_RS03455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K529_RS03480	COG0697	spore germination
K529_RS03505	COG2983	Belongs to the UPF0260 family
K529_RS03510	COG0196	riboflavin kinase activity
K529_RS03530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_RS03530	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K529_RS03540	COG0251	oxidation-reduction process
K529_RS03545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_RS03555	COG4717	serine-type aminopeptidase activity
K529_RS03560	COG0420	3'-5' exonuclease activity
K529_RS03575	COG0583	DNA-binding transcription factor activity
K529_RS03590	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K529_RS03595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K529_RS03600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K529_RS03605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K529_RS03605	COG1618	nucleotide phosphatase activity, acting on free nucleotides
K529_RS03610	COG1832	CoA-binding protein
K529_RS03625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K529_RS03630	COG0140	phosphoribosyl-ATP diphosphatase activity
K529_RS03635	COG0107	imidazoleglycerol-phosphate synthase activity
K529_RS03650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K529_RS03675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K529_RS03690	COG0131	Imidazoleglycerol-phosphate dehydratase
K529_RS03700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K529_RS03730	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K529_RS03750	COG0210	DNA helicase
K529_RS03770	COG0489	protein tyrosine kinase activity
K529_RS03780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K529_RS03785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K529_RS03790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K529_RS03805	COG0275	rRNA processing
K529_RS03810	COG2001	Belongs to the MraZ family
K529_RS03895	COG4397	Mu-like prophage major head subunit gpT
K529_RS03905	COG4388	Caudovirus prohead serine protease
K529_RS03920	COG2369	cell adhesion
K529_RS03935	COG4373	Mu-like prophage FluMu protein gp28
K529_RS04010	COG2801	Transposase and inactivated derivatives
K529_RS04110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K529_RS04125	COG1492	cobalamin metabolic process
K529_RS04135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K529_RS04145	COG0354	folic acid binding
K529_RS04150	COG1132	(ABC) transporter
K529_RS04155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K529_RS04165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K529_RS04170	COG1024	Enoyl-CoA hydratase
K529_RS04180	COG0840	transmembrane signaling receptor activity
K529_RS04185	COG3588	fructose-bisphosphate aldolase
K529_RS04200	COG0504	CTP synthase activity
K529_RS04225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K529_RS04255	COG1309	transcriptional regulator
K529_RS04260	COG1760	l-serine dehydratase
K529_RS04265	COG0625	glutathione transferase activity
K529_RS04270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K529_RS04300	COG0330	HflC and HflK could
K529_RS04305	COG3239	Fatty acid desaturase
K529_RS04350	COG1570	exodeoxyribonuclease VII activity
K529_RS04365	COG0552	protein localization to endoplasmic reticulum
K529_RS04370	COG1285	pathogenesis
K529_RS04400	COG1469	GTP cyclohydrolase I activity
K529_RS04410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K529_RS04415	COG0527	aspartate kinase activity
K529_RS04435	COG0028	Belongs to the TPP enzyme family
K529_RS04440	COG0625	glutathione transferase activity
K529_RS04450	COG3853	Toxic anion resistance protein (TelA)
K529_RS04460	COG1187	pseudouridine synthase activity
K529_RS04465	COG0590	tRNA wobble adenosine to inosine editing
K529_RS04475	COG1309	transcriptional regulator
K529_RS04485	COG2818	Glycosylase
K529_RS04490	COG0006	proline dipeptidase activity
K529_RS04495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K529_RS04505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K529_RS04510	COG0154	amidase activity
K529_RS04520	COG3023	N-Acetylmuramoyl-L-alanine amidase
K529_RS04530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K529_RS04540	COG0670	Belongs to the BI1 family
K529_RS04550	COG0583	DNA-binding transcription factor activity
K529_RS04555	COG0604	alcohol dehydrogenase
K529_RS04555	COG3321	synthase
K529_RS04560	COG1396	sequence-specific DNA binding
K529_RS04565	COG0483	inositol monophosphate 1-phosphatase activity
K529_RS04575	COG0402	S-adenosylhomocysteine deaminase activity
K529_RS04580	COG2239	Acts as a magnesium transporter
K529_RS04585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K529_RS04600	COG1692	metallophosphoesterase
K529_RS04605	COG0471	metal ion transport
K529_RS04605	COG3273	potassium ion transport
K529_RS04625	COG0471	metal ion transport
K529_RS04625	COG3273	potassium ion transport
K529_RS04635	COG0217	transcriptional regulatory protein
K529_RS04660	COG1741	Belongs to the pirin family
K529_RS04665	COG0488	(ABC) transporter
K529_RS04675	COG0697	spore germination
K529_RS04685	COG1309	transcriptional regulator
K529_RS04715	COG1396	sequence-specific DNA binding
K529_RS04715	COG3800	Transcriptional regulator
K529_RS04720	COG2814	Major facilitator Superfamily
K529_RS04725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K529_RS04760	COG4770	biotin carboxylase activity
K529_RS04780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K529_RS04780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K529_RS04800	COG1247	-acetyltransferase
K529_RS04835	COG0248	Ppx GppA phosphatase
K529_RS04850	COG0628	permease
K529_RS04860	COG0442	prolyl-tRNA aminoacylation
K529_RS04890	COG1136	(ABC) transporter
K529_RS04905	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K529_RS04915	COG2079	MmgE PrpD family protein
K529_RS04925	COG1396	sequence-specific DNA binding
K529_RS04925	COG3800	Transcriptional regulator
K529_RS04930	COG0517	IMP dehydrogenase activity
K529_RS04930	COG0617	tRNA 3'-terminal CCA addition
K529_RS04930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K529_RS04960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K529_RS04965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_RS04970	COG0174	glutamine synthetase
K529_RS04975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K529_RS04975	COG0519	Catalyzes the synthesis of GMP from XMP
K529_RS04980	COG0174	glutamine synthetase
K529_RS05005	COG1278	Cold shock
K529_RS05025	COG1132	(ABC) transporter
K529_RS05035	COG0318	PFAM AMP-dependent synthetase and ligase
K529_RS05040	COG0657	acetylesterase activity
K529_RS05065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS05070	COG0601	transmembrane transport
K529_RS05080	COG1490	D-aminoacyl-tRNA deacylase activity
K529_RS05095	COG2124	cytochrome p450
K529_RS05105	COG2204	response regulator
K529_RS05110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_RS05115	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K529_RS05120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_RS05125	COG0513	Belongs to the DEAD box helicase family
K529_RS05135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K529_RS05155	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS05160	COG4335	DNA alkylation repair
K529_RS05165	COG3842	ATPase activity
K529_RS05185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K529_RS05190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K529_RS05195	COG0805	protein transport
K529_RS05210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K529_RS05215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K529_RS05220	COG4221	oxidoreductase activity
K529_RS05265	COG1127	ABC transporter
K529_RS05270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K529_RS05275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K529_RS05295	COG0305	Participates in initiation and elongation during chromosome replication
K529_RS05300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K529_RS05305	COG0418	dihydroorotase activity
K529_RS05345	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K529_RS05370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K529_RS05390	COG0175	sulfate reduction
K529_RS05395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K529_RS05405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K529_RS05405	COG1648	precorrin-2 dehydrogenase activity
K529_RS05410	COG1522	sequence-specific DNA binding
K529_RS05475	COG3609	addiction module antidote protein, CC2985 family
K529_RS05570	COG0004	ammonium transporteR
K529_RS05585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K529_RS05590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K529_RS05615	COG2267	carboxylic ester hydrolase activity
K529_RS05630	COG3739	integral membrane protein
K529_RS05650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K529_RS05660	COG0154	amidase activity
K529_RS05665	COG3237	CsbD-like
K529_RS05675	COG0280	phosphate acetyltransferase
K529_RS05675	COG0281	malic enzyme
K529_RS05685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K529_RS05690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K529_RS05695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K529_RS05720	COG1902	pentaerythritol trinitrate reductase activity
K529_RS05725	COG2814	Major facilitator Superfamily
K529_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS05740	COG0583	DNA-binding transcription factor activity
K529_RS05745	COG0318	PFAM AMP-dependent synthetase and ligase
K529_RS05765	COG1250	3-hydroxyacyl-CoA dehydrogenase
K529_RS05765	COG1024	Enoyl-CoA hydratase
K529_RS05770	COG0183	Belongs to the thiolase family
K529_RS05775	COG0625	glutathione transferase activity
K529_RS05780	COG1960	acyl-CoA dehydrogenase activity
K529_RS05790	COG1960	acyl-CoA dehydrogenase activity
K529_RS05795	COG0789	Transcriptional regulator
K529_RS05820	COG0534	Mate efflux family protein
K529_RS05835	COG0737	Belongs to the 5'-nucleotidase family
K529_RS05855	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K529_RS05865	COG1320	monovalent cation:proton antiporter activity
K529_RS05870	COG2212	antiporter activity
K529_RS05875	COG1863	multisubunit Na H antiporter MnhE subunit
K529_RS05880	COG0651	ATP synthesis coupled electron transport
K529_RS05885	COG1006	Multisubunit Na H antiporter MnhC subunit
K529_RS05890	COG2111	Na H antiporter
K529_RS05890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K529_RS05905	COG2943	transferase activity, transferring hexosyl groups
K529_RS05910	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K529_RS05925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_RS05945	COG0740	serine-type endopeptidase activity
K529_RS05950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K529_RS05985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K529_RS05990	COG0439	Biotin carboxylase
K529_RS05995	COG0511	ligase activity, forming carbon-carbon bonds
K529_RS06005	COG0410	ABC transporter
K529_RS06030	COG1396	sequence-specific DNA binding
K529_RS06030	COG3800	Transcriptional regulator
K529_RS06070	COG3750	Belongs to the UPF0335 family
K529_RS06075	COG0493	'glutamate synthase
K529_RS06085	COG1309	transcriptional regulator
K529_RS06100	COG1116	anion transmembrane transporter activity
K529_RS06105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K529_RS06110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K529_RS06135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K529_RS06150	COG0840	transmembrane signaling receptor activity
K529_RS06160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K529_RS06175	COG0583	DNA-binding transcription factor activity
K529_RS06180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K529_RS06185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K529_RS06190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K529_RS06195	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K529_RS06205	COG2166	iron-sulfur cluster assembly
K529_RS06215	COG5012	cobalamin binding
K529_RS06225	COG0646	methionine synthase
K529_RS06225	COG1410	methionine synthase
K529_RS06240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K529_RS06245	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K529_RS06250	COG0047	phosphoribosylformylglycinamidine synthase activity
K529_RS06265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K529_RS06270	COG1530	ribonuclease E activity
K529_RS06275	COG0425	Belongs to the sulfur carrier protein TusA family
K529_RS06280	COG0785	Cytochrome C biogenesis protein
K529_RS06310	COG0114	fumarate hydratase activity
K529_RS06345	COG2188	Transcriptional regulator
K529_RS06360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K529_RS06365	COG0604	alcohol dehydrogenase
K529_RS06370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K529_RS06375	COG0415	Belongs to the DNA photolyase family
K529_RS06390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K529_RS06390	COG3264	Mechanosensitive ion channel
K529_RS06400	COG0483	inositol monophosphate 1-phosphatase activity
K529_RS06415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K529_RS06420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K529_RS06425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K529_RS06435	COG4974	Belongs to the 'phage' integrase family
K529_RS06440	COG4536	flavin adenine dinucleotide binding
K529_RS06450	COG0629	single-stranded DNA binding
K529_RS06455	COG0739	heme binding
K529_RS06455	COG0741	lytic transglycosylase activity
K529_RS06455	COG1196	nuclear chromosome segregation
K529_RS06465	COG1858	cytochrome C peroxidase
K529_RS06480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS06485	COG0601	transmembrane transport
K529_RS06500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K529_RS06505	COG0528	UMP kinase activity
K529_RS06510	COG0233	cytoplasmic translational termination
K529_RS06515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K529_RS06525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K529_RS06530	COG0750	zinc metalloprotease
K529_RS06535	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K529_RS06545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K529_RS06550	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K529_RS06560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K529_RS06565	COG0482	sulfurtransferase activity
K529_RS06575	COG0745	RESPONSE REGULATOR receiver
K529_RS06580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K529_RS06585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K529_RS06595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K529_RS06600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K529_RS06605	COG2264	protein methyltransferase activity
K529_RS06610	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K529_RS06620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K529_RS06625	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K529_RS06635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K529_RS06640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K529_RS06645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K529_RS06650	COG0840	transmembrane signaling receptor activity
K529_RS06655	COG1309	transcriptional regulator
K529_RS06660	COG2326	polyphosphate kinase activity
K529_RS06670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K529_RS06695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K529_RS06695	COG0519	Catalyzes the synthesis of GMP from XMP
K529_RS06715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K529_RS06720	COG1473	amidohydrolase
K529_RS06730	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K529_RS06735	COG2867	negative regulation of translational initiation
K529_RS06740	COG1546	Belongs to the CinA family
K529_RS06745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K529_RS06750	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K529_RS06750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K529_RS06755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K529_RS06760	COG3852	Histidine kinase
K529_RS06765	COG2204	response regulator
K529_RS06770	COG5000	phosphorelay sensor kinase activity
K529_RS06775	COG2204	response regulator
K529_RS06780	COG0569	domain protein
K529_RS06785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K529_RS06790	COG1923	regulation of RNA biosynthetic process
K529_RS06795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K529_RS06805	COG2084	Dehydrogenase
K529_RS06825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K529_RS06830	COG2814	Major facilitator Superfamily
K529_RS06855	COG4166	transmembrane transport
K529_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS06875	COG2313	pseudouridylate synthase activity
K529_RS06895	COG1612	heme a metabolic process
K529_RS06900	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K529_RS06910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K529_RS06915	COG5425	PFAM Usg family protein
K529_RS06920	COG0363	glucosamine-6-phosphate deaminase activity
K529_RS06985	COG2133	pyrroloquinoline quinone binding
K529_RS06995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K529_RS07005	COG1561	YicC-like family, N-terminal region
K529_RS07010	COG0194	GDP metabolic process
K529_RS07020	COG0626	cystathionine gamma-synthase activity
K529_RS07025	COG5002	protein histidine kinase activity
K529_RS07035	COG0573	inorganic phosphate transmembrane transporter activity
K529_RS07045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K529_RS07050	COG0704	Plays a role in the regulation of phosphate uptake
K529_RS07055	COG0745	RESPONSE REGULATOR receiver
K529_RS07060	COG0583	DNA-binding transcription factor activity
K529_RS07065	COG1960	acyl-CoA dehydrogenase activity
K529_RS07070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K529_RS07080	COG2358	TRAP transporter, solute receptor (TAXI family
K529_RS07125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K529_RS07140	COG0719	Fe-S assembly protein
K529_RS07145	COG0396	ATPase activity
K529_RS07155	COG0393	Putative heavy-metal-binding
K529_RS07160	COG0719	Fe-S assembly protein
K529_RS07170	COG1959	2 iron, 2 sulfur cluster binding
K529_RS07175	COG2945	thiolester hydrolase activity
K529_RS07190	COG2076	Multidrug Resistance protein
K529_RS07195	COG1217	gtp-binding protein TYPA
K529_RS07200	COG0121	glutamine amidotransferase
K529_RS07210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K529_RS07220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K529_RS07235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K529_RS07235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K529_RS07245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_RS07250	COG0517	IMP dehydrogenase activity
K529_RS07250	COG0516	GMP reductase activity
K529_RS07255	COG0433	COG0433 Predicted ATPase
K529_RS07275	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K529_RS07280	COG0793	Belongs to the peptidase S41A family
K529_RS07285	COG3108	Peptidase M15
K529_RS07305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K529_RS07310	COG2197	response regulator
K529_RS07315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K529_RS07320	COG0052	Belongs to the universal ribosomal protein uS2 family
K529_RS07345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K529_RS07350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K529_RS07355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K529_RS07365	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K529_RS07370	COG3743	rRNA binding
K529_RS07370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K529_RS07395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K529_RS07405	COG0248	Ppx GppA phosphatase
K529_RS07410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K529_RS07435	COG0577	efflux transmembrane transporter activity
K529_RS07450	COG1653	transport
K529_RS07460	COG0395	ABC-type sugar transport system, permease component
K529_RS07465	COG3842	ATPase activity
K529_RS07470	COG0840	transmembrane signaling receptor activity
K529_RS07535	COG1238	metal cluster binding
K529_RS07550	COG0010	Belongs to the arginase family
K529_RS07595	COG2814	Major facilitator Superfamily
K529_RS07605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K529_RS07610	COG0215	cysteine-tRNA ligase activity
K529_RS07620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K529_RS07640	COG0259	pyridoxamine-phosphate oxidase activity
K529_RS07645	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K529_RS07650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K529_RS07665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K529_RS07680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K529_RS07685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K529_RS07705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K529_RS07710	COG2333	competence protein COMEC
K529_RS07710	COG0658	competence protein
K529_RS07715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K529_RS07720	COG0372	Belongs to the citrate synthase family
K529_RS07730	COG1024	Enoyl-CoA hydratase
K529_RS07740	COG3088	subunit of a heme lyase
K529_RS07745	COG1138	Cytochrome C-type biogenesis protein
K529_RS07760	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K529_RS07765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K529_RS07770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K529_RS07790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K529_RS07810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K529_RS07825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K529_RS07830	COG2354	Protein conserved in bacteria
K529_RS07840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K529_RS07900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K529_RS07910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K529_RS07930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K529_RS07940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K529_RS07945	COG2833	Protein of unknown function (DUF455)
K529_RS07950	COG0739	heme binding
K529_RS07975	COG0126	phosphoglycerate kinase activity
K529_RS07990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K529_RS07995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K529_RS08000	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_RS08000	COG0022	dehydrogenase e1 component
K529_RS08005	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_RS08015	COG1278	Cold shock
K529_RS08095	COG4695	Portal protein
K529_RS08110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K529_RS08115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K529_RS08120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K529_RS08125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K529_RS08135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K529_RS08140	COG3038	cytochrome b561
K529_RS08155	COG2353	YceI-like domain
K529_RS08165	COG0360	Binds together with S18 to 16S ribosomal RNA
K529_RS08170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K529_RS08175	COG0359	binds to the 23S rRNA
K529_RS08180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_RS08185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_RS08190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_RS08205	COG0737	Belongs to the 5'-nucleotidase family
K529_RS08210	COG3706	GGDEF domain
K529_RS08215	COG0544	peptidyl-prolyl cis-trans isomerase activity
K529_RS08225	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K529_RS08230	COG4251	negative regulation of phosphorylation
K529_RS08245	COG0840	transmembrane signaling receptor activity
K529_RS08250	COG1049	propionate catabolic process, 2-methylcitrate cycle
K529_RS08260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K529_RS08275	COG0443	Heat shock 70 kDa protein
K529_RS08295	COG0006	proline dipeptidase activity
K529_RS08320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K529_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS08365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K529_RS08375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K529_RS08380	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K529_RS08385	COG4133	protoheme IX ABC transporter activity
K529_RS08390	COG3737	Protein of unknown function (DUF498/DUF598)
K529_RS08405	COG1862	Preprotein translocase
K529_RS08410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K529_RS08420	COG3239	Fatty acid desaturase
K529_RS08425	COG2095	MarC family integral membrane protein
K529_RS08430	COG1160	GTP binding
K529_RS08435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K529_RS08450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K529_RS08465	COG0840	transmembrane signaling receptor activity
K529_RS08490	COG5265	(ABC) transporter
K529_RS08540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K529_RS08540	COG0446	pyridine nucleotide-disulphide oxidoreductase
K529_RS08555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_RS08560	COG4235	cytochrome complex assembly
K529_RS08565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K529_RS08580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K529_RS08585	COG2198	Histidine kinase
K529_RS08585	COG5002	protein histidine kinase activity
K529_RS08585	COG0784	Response regulator, receiver
K529_RS08610	COG0105	UTP biosynthetic process
K529_RS08615	COG2814	Major facilitator Superfamily
K529_RS08625	COG0488	(ABC) transporter
K529_RS08630	COG2095	MarC family integral membrane protein
K529_RS08645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K529_RS08665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K529_RS08670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K529_RS08675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K529_RS08685	COG2890	protein-(glutamine-N5) methyltransferase activity
K529_RS08690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K529_RS08705	COG0010	Belongs to the arginase family
K529_RS08710	COG1473	amidohydrolase
K529_RS08715	COG3956	TIGRFAM MazG family protein
K529_RS08720	COG1957	nucleoside hydrolase
K529_RS08725	COG0456	acetyltransferase
K529_RS08735	COG0148	phosphopyruvate hydratase activity
K529_RS08745	COG0697	spore germination
K529_RS08760	COG0513	Belongs to the DEAD box helicase family
K529_RS08765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K529_RS08775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K529_RS08780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K529_RS08795	COG0488	(ABC) transporter
K529_RS08815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K529_RS08820	COG0416	fatty acid biosynthetic process
K529_RS08825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K529_RS08830	COG0776	regulation of translation
K529_RS08845	COG0717	Belongs to the dCTP deaminase family
K529_RS08855	COG2814	Major facilitator Superfamily
K529_RS08865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K529_RS08870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K529_RS08875	COG1472	Belongs to the glycosyl hydrolase 3 family
K529_RS08885	COG0018	arginyl-trna synthetase
K529_RS08890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K529_RS08895	COG0316	Belongs to the HesB IscA family
K529_RS08920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K529_RS08960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K529_RS08970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K529_RS08980	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K529_RS08995	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K529_RS09000	COG0346	lactoylglutathione lyase activity
K529_RS09005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_RS09030	COG0028	Belongs to the TPP enzyme family
K529_RS09035	COG0440	acetolactate synthase activity
K529_RS09060	COG1280	lysine exporter protein (LysE YggA)
K529_RS09070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K529_RS09075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K529_RS09085	COG0860	N-Acetylmuramoyl-L-alanine amidase
K529_RS09090	COG0436	Aminotransferase
K529_RS09100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K529_RS09100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K529_RS09105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K529_RS09110	COG1426	Protein conserved in bacteria
K529_RS09115	COG0156	8-amino-7-oxononanoate synthase activity
K529_RS09125	COG1607	acyl-coa hydrolase
K529_RS09150	COG5507	3-demethylubiquinone-9 3-methyltransferase
K529_RS09155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K529_RS09160	COG0602	queuosine metabolic process
K529_RS09165	COG0720	synthase
K529_RS09170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K529_RS09185	COG0406	alpha-ribazole phosphatase activity
K529_RS09190	COG1283	sodium-dependent phosphate transmembrane transporter activity
K529_RS09200	COG0584	glycerophosphoryl diester phosphodiesterase
K529_RS09205	COG3842	ATPase activity
K529_RS09210	COG0395	ABC-type sugar transport system, permease component
K529_RS09220	COG1653	transport
K529_RS09225	COG0583	DNA-binding transcription factor activity
K529_RS09230	COG3842	ATPase activity
K529_RS09235	COG1177	transmembrane transport
K529_RS09250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K529_RS09255	COG2267	carboxylic ester hydrolase activity
K529_RS09265	COG2197	response regulator
K529_RS09275	COG0583	DNA-binding transcription factor activity
K529_RS09290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K529_RS09335	COG4948	Mandelate Racemase Muconate Lactonizing
K529_RS09345	COG0583	DNA-binding transcription factor activity
K529_RS09375	COG2188	Transcriptional regulator
K529_RS09390	COG2267	carboxylic ester hydrolase activity
K529_RS09395	COG0840	transmembrane signaling receptor activity
K529_RS09400	COG3842	ATPase activity
K529_RS09410	COG1177	transmembrane transport
K529_RS09420	COG1574	metal-dependent hydrolase with the TIM-barrel fold
K529_RS09435	COG0840	transmembrane signaling receptor activity
K529_RS09445	COG0776	regulation of translation
K529_RS09455	COG1902	pentaerythritol trinitrate reductase activity
K529_RS09470	COG0343	queuine tRNA-ribosyltransferase activity
K529_RS09475	COG0189	ligase activity
K529_RS09475	COG4067	protein conserved in archaea
K529_RS09495	COG2151	metal-sulfur cluster biosynthetic enzyme
K529_RS09500	COG0316	Belongs to the HesB IscA family
K529_RS09505	COG0149	triose-phosphate isomerase activity
K529_RS09520	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K529_RS09530	COG1007	ATP synthesis coupled electron transport
K529_RS09545	COG0713	ATP synthesis coupled electron transport
K529_RS09560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K529_RS09565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K529_RS09615	COG0649	NAD binding
K529_RS09620	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K529_RS09625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K529_RS09635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K529_RS09645	COG4770	biotin carboxylase activity
K529_RS09650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K529_RS09660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K529_RS09665	COG3047	cAMP biosynthetic process
K529_RS09675	COG1960	acyl-CoA dehydrogenase activity
K529_RS09695	COG0546	phosphoglycolate phosphatase activity
K529_RS09700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K529_RS09720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K529_RS09725	COG1519	Transferase
K529_RS09730	COG0438	transferase activity, transferring glycosyl groups
K529_RS09750	COG1473	amidohydrolase
K529_RS09755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K529_RS09760	COG4172	Belongs to the ABC transporter superfamily
K529_RS09770	COG0601	transmembrane transport
K529_RS09775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS09785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K529_RS09790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K529_RS09800	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K529_RS09810	COG0308	aminopeptidase N
K529_RS09825	COG2183	response to ionizing radiation
K529_RS09830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K529_RS09840	COG1739	Uncharacterized protein family UPF0029
K529_RS09855	COG1872	DUF167
K529_RS09860	COG0778	Nitroreductase
K529_RS09880	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K529_RS09890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K529_RS09895	COG0849	cell division
K529_RS09900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K529_RS09905	COG1181	Belongs to the D-alanine--D-alanine ligase family
K529_RS09910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K529_RS09930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K529_RS09935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K529_RS09945	COG2081	HI0933 family
K529_RS09950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K529_RS09955	COG0481	GTPase activity
K529_RS09965	COG0583	DNA-binding transcription factor activity
K529_RS09970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K529_RS09975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K529_RS09990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K529_RS09995	COG1703	isobutyryl-CoA mutase activity
K529_RS10005	COG1643	Atp-dependent helicase
K529_RS10015	COG0306	phosphate transporter
K529_RS10025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K529_RS10030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K529_RS10040	COG0842	Transport permease protein
K529_RS10065	COG1280	lysine exporter protein (LysE YggA)
K529_RS10085	COG0625	glutathione transferase activity
K529_RS10095	COG1573	uracil-dna glycosylase
K529_RS10110	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K529_RS10125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K529_RS10130	COG2195	Cleaves the N-terminal amino acid of tripeptides
K529_RS10165	COG0006	proline dipeptidase activity
K529_RS10175	COG0583	DNA-binding transcription factor activity
K529_RS10200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K529_RS10210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K529_RS10210	COG0512	Glutamine amidotransferase of anthranilate synthase
K529_RS10215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K529_RS10250	COG1435	thymidine kinase activity
K529_RS10260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K529_RS10280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K529_RS10290	COG1496	oxidoreductase activity
K529_RS10300	COG1522	sequence-specific DNA binding
K529_RS10305	COG0492	ferredoxin-NADP+ reductase activity
K529_RS10315	COG0529	Catalyzes the synthesis of activated sulfate
K529_RS10315	COG2046	Belongs to the sulfate adenylyltransferase family
K529_RS10325	COG0071	Belongs to the small heat shock protein (HSP20) family
K529_RS10335	COG0306	phosphate transporter
K529_RS10350	COG0384	phenazine biosynthesis protein PhzF
K529_RS10355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K529_RS10360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K529_RS10365	COG3454	Phosphonate metabolism
K529_RS10385	COG0459	protein refolding
K529_RS10390	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K529_RS10415	COG1227	inorganic diphosphatase activity
K529_RS10435	COG1846	Transcriptional regulator
K529_RS10450	COG2030	dehydratase
K529_RS10465	COG2873	o-acetylhomoserine
K529_RS10495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K529_RS10495	COG0475	glutathione-regulated potassium exporter activity
K529_RS10500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K529_RS10505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K529_RS10510	COG1329	Transcriptional regulator
K529_RS10515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K529_RS10555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K529_RS10580	COG0583	DNA-binding transcription factor activity
K529_RS10590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K529_RS10595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K529_RS10600	COG3485	protocatechuate 3,4-dioxygenase
K529_RS10605	COG3485	protocatechuate 3,4-dioxygenase
K529_RS10610	COG3246	L-lysine catabolic process to acetate
K529_RS10625	COG1595	DNA-templated transcription, initiation
K529_RS10635	COG0527	aspartate kinase activity
K529_RS10640	COG1917	Cupin 2, conserved barrel domain protein
K529_RS10645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K529_RS10685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K529_RS10690	COG1176	ABC-type spermidine putrescine transport system, permease component I
K529_RS10700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K529_RS10705	COG0588	phosphoglycerate mutase activity
K529_RS10725	COG0631	protein serine/threonine phosphatase activity
K529_RS10815	COG0739	heme binding
K529_RS10840	COG0811	peptide transport
K529_RS10880	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K529_RS10885	COG2719	SpoVR family
K529_RS10890	COG2718	Belongs to the UPF0229 family
K529_RS10895	COG2766	serine protein kinase
K529_RS10910	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
K529_RS10915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K529_RS10920	COG3591	Belongs to the peptidase S1B family
K529_RS10930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K529_RS10940	COG0798	PFAM Bile acid sodium symporter
K529_RS10955	COG1780	Probably involved in ribonucleotide reductase function
K529_RS10960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K529_RS10965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K529_RS10985	COG1012	belongs to the aldehyde dehydrogenase family
K529_RS10995	COG0583	DNA-binding transcription factor activity
K529_RS11000	COG1473	amidohydrolase
K529_RS11035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K529_RS11040	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K529_RS11045	COG0124	histidyl-tRNA synthetase
K529_RS11065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K529_RS11070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K529_RS11075	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K529_RS11095	COG0612	Peptidase, M16
K529_RS11105	COG3346	SURF1 family
K529_RS11115	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K529_RS11125	COG0109	protoheme IX farnesyltransferase activity
K529_RS11135	COG0312	modulator of DNA gyrase
K529_RS11140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K529_RS11140	COG0758	DNA mediated transformation
K529_RS11145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K529_RS11145	COG1754	DNA topoisomerase type I activity
K529_RS11150	COG1309	transcriptional regulator
K529_RS11190	COG4964	Belongs to the GSP D family
K529_RS11195	COG2885	chlorophyll binding
K529_RS11245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K529_RS11255	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K529_RS11270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K529_RS11275	COG0037	tRNA processing
K529_RS11285	COG2885	chlorophyll binding
K529_RS11290	COG0823	Involved in the tonB-independent uptake of proteins
K529_RS11310	COG0824	Thioesterase
K529_RS11325	COG2255	four-way junction helicase activity
K529_RS11330	COG0632	four-way junction helicase activity
K529_RS11335	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K529_RS11350	COG2264	protein methyltransferase activity
K529_RS11365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K529_RS11380	COG1183	phosphatidylcholine synthase activity
K529_RS11390	COG0101	tRNA pseudouridine synthase activity
K529_RS11395	COG3106	COG3106 Predicted ATPase
K529_RS11405	COG3768	UPF0283 membrane protein
K529_RS11420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K529_RS11435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K529_RS11435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K529_RS11440	COG0509	glycine decarboxylation via glycine cleavage system
K529_RS11445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K529_RS11555	COG0116	Belongs to the methyltransferase superfamily
K529_RS11555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K529_RS11565	COG3842	ATPase activity
K529_RS11570	COG3842	ATPase activity
K529_RS11575	COG1175	transmembrane transport
K529_RS11580	COG0395	ABC-type sugar transport system, permease component
K529_RS11635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K529_RS11645	COG1660	Displays ATPase and GTPase activities
K529_RS11655	COG2205	protein histidine kinase activity
K529_RS11660	COG0745	RESPONSE REGULATOR receiver
K529_RS11665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K529_RS11685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K529_RS11705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K529_RS11710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K529_RS11715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K529_RS11720	COG0840	transmembrane signaling receptor activity
K529_RS11725	COG1846	Transcriptional regulator
K529_RS11730	COG0697	spore germination
K529_RS11740	COG1051	belongs to the nudix hydrolase family
K529_RS11745	COG0446	pyridine nucleotide-disulphide oxidoreductase
K529_RS11745	COG1902	pentaerythritol trinitrate reductase activity
K529_RS11750	COG2070	2-Nitropropane dioxygenase
K529_RS11755	COG0583	DNA-binding transcription factor activity
K529_RS11775	COG1280	lysine exporter protein (LysE YggA)
K529_RS11795	COG1058	Belongs to the CinA family
K529_RS11795	COG1546	Belongs to the CinA family
K529_RS11800	COG1489	DNA binding
K529_RS11805	COG0668	transmembrane transport
K529_RS11810	COG0024	Methionine aminopeptidase
K529_RS11815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K529_RS11820	COG0742	ribosomal rna small subunit methyltransferase
K529_RS11830	COG0678	peroxiredoxin activity
K529_RS11840	COG2154	pterin-4-alpha-carbinolamine dehydratase
K529_RS11880	COG1476	TRANSCRIPTIONal
K529_RS11890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K529_RS11895	COG0697	spore germination
K529_RS11900	COG1396	sequence-specific DNA binding
K529_RS11905	COG3135	benzoate transporter
K529_RS11910	COG0129	dihydroxy-acid dehydratase activity
K529_RS11955	COG0697	spore germination
K529_RS11965	COG0071	Belongs to the small heat shock protein (HSP20) family
K529_RS11970	COG3591	Belongs to the peptidase S1B family
K529_RS11975	COG0247	lactate metabolic process
K529_RS11985	COG0277	FAD linked oxidase domain protein
K529_RS11990	COG0277	FAD linked oxidase domain protein
K529_RS12005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K529_RS12010	COG0799	negative regulation of ribosome biogenesis
K529_RS12015	COG3264	Mechanosensitive ion channel
K529_RS12015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K529_RS12020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K529_RS12025	COG0066	3-isopropylmalate dehydratase activity
K529_RS12030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K529_RS12040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K529_RS12045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K529_RS12055	COG0469	pyruvate kinase activity
K529_RS12075	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K529_RS12080	COG0322	excinuclease ABC activity
K529_RS12085	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS12100	COG0842	Transport permease protein
K529_RS12105	COG1131	(ABC) transporter
K529_RS12115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_RS12120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K529_RS12125	COG0181	hydroxymethylbilane synthase activity
K529_RS12140	COG0408	coproporphyrinogen oxidase activity
K529_RS12145	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS12155	COG2813	Specifically methylates the guanine in position
K529_RS12160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K529_RS12170	COG1686	Belongs to the peptidase S11 family
K529_RS12190	COG0348	domain, Protein
K529_RS12195	COG0583	DNA-binding transcription factor activity
K529_RS12205	COG2010	Cytochrome c
K529_RS12240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K529_RS12245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K529_RS12250	COG4172	Belongs to the ABC transporter superfamily
K529_RS12255	COG4239	(ABC) transporter, permease
K529_RS12260	COG4174	ABC transporter (Permease)
K529_RS12275	COG0077	Prephenate dehydratase
K529_RS12275	COG1605	Chorismate mutase
K529_RS12285	COG1381	Involved in DNA repair and RecF pathway recombination
K529_RS12295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K529_RS12300	COG0571	ribonuclease III activity
K529_RS12305	COG0681	Belongs to the peptidase S26 family
K529_RS12310	COG0736	holo-[acyl-carrier-protein] synthase activity
K529_RS12320	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K529_RS12330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K529_RS12335	COG1758	RNA polymerase activity
K529_RS12340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K529_RS12350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K529_RS12370	COG0328	RNA-DNA hybrid ribonuclease activity
K529_RS12375	COG2860	membrane
K529_RS12390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K529_RS12395	COG0242	peptide deformylase activity
K529_RS12400	COG0242	peptide deformylase activity
K529_RS12410	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K529_RS12420	COG0435	Glutathione S-transferase
K529_RS12430	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K529_RS12435	COG3773	Cell wall hydrolase
K529_RS12435	COG3409	Peptidoglycan-binding domain 1 protein
K529_RS12445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K529_RS12455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K529_RS12460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K529_RS12465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K529_RS12470	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K529_RS12475	COG0356	it plays a direct role in the translocation of protons across the membrane
K529_RS12505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K529_RS12520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K529_RS12540	COG0228	four-way junction DNA binding
K529_RS12545	COG0778	Nitroreductase
K529_RS12550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K529_RS12560	COG0336	Belongs to the RNA methyltransferase TrmD family
K529_RS12580	COG2814	Major facilitator Superfamily
K529_RS12585	COG0335	large ribosomal subunit rRNA binding
K529_RS12590	COG0254	rRNA binding
K529_RS12595	COG0489	protein tyrosine kinase activity
K529_RS12595	COG2151	metal-sulfur cluster biosynthetic enzyme
K529_RS12610	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K529_RS12615	COG0179	Fumarylacetoacetate (FAA) hydrolase
K529_RS12635	COG0625	glutathione transferase activity
K529_RS12640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K529_RS12645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K529_RS12650	COG0347	Belongs to the P(II) protein family
K529_RS12655	COG0004	ammonium transporteR
K529_RS12675	COG2897	thiosulfate sulfurtransferase activity
K529_RS12685	COG3622	Belongs to the hyi family
K529_RS12690	COG0673	inositol 2-dehydrogenase activity
K529_RS12705	COG1879	ABC-type sugar transport system periplasmic component
K529_RS12720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K529_RS12725	COG3962	Belongs to the TPP enzyme family
K529_RS12735	COG3718	enzyme involved in inositol metabolism
K529_RS12745	COG1177	transmembrane transport
K529_RS12755	COG3842	ATPase activity
K529_RS12785	COG0312	modulator of DNA gyrase
K529_RS12790	COG0483	inositol monophosphate 1-phosphatase activity
K529_RS12800	COG1663	tetraacyldisaccharide 4'-kinase activity
K529_RS12815	COG1194	a g-specific adenine glycosylase
K529_RS12825	COG0840	transmembrane signaling receptor activity
K529_RS12840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K529_RS12865	COG1012	belongs to the aldehyde dehydrogenase family
K529_RS12875	COG1522	sequence-specific DNA binding
K529_RS12880	COG3022	response to hydroperoxide
K529_RS12885	COG0514	ATP-dependent DNA helicase (RecQ)
K529_RS12905	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K529_RS12925	COG3191	aminopeptidase activity
K529_RS12930	COG0697	spore germination
K529_RS12940	COG2423	ornithine cyclodeaminase activity
K529_RS12945	COG2267	carboxylic ester hydrolase activity
K529_RS12955	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K529_RS12970	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K529_RS12980	COG1132	(ABC) transporter
K529_RS13000	COG2169	Transcriptional regulator
K529_RS13000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K529_RS13050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K529_RS13060	COG3119	arylsulfatase activity
K529_RS13105	COG4608	Belongs to the ABC transporter superfamily
K529_RS13110	COG0444	Belongs to the ABC transporter superfamily
K529_RS13120	COG0747	negative chemotaxis
K529_RS13145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K529_RS13150	COG1012	belongs to the aldehyde dehydrogenase family
K529_RS13155	COG1522	sequence-specific DNA binding
K529_RS13160	COG3608	succinylglutamate desuccinylase aspartoacylase
K529_RS13165	COG4977	sequence-specific DNA binding
K529_RS13175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_RS13180	COG1120	ATPase activity
K529_RS13200	COG1414	Transcriptional regulator
K529_RS13205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K529_RS13210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K529_RS13215	COG3616	Alanine racemase, N-terminal domain
K529_RS13220	COG2423	ornithine cyclodeaminase activity
K529_RS13235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K529_RS13250	COG1522	sequence-specific DNA binding
K529_RS13255	COG0133	tryptophan synthase activity
K529_RS13260	COG0006	proline dipeptidase activity
K529_RS13270	COG0006	proline dipeptidase activity
K529_RS13275	COG0747	negative chemotaxis
K529_RS13285	COG0601	transmembrane transport
K529_RS13290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS13295	COG0444	Belongs to the ABC transporter superfamily
K529_RS13315	COG0784	Response regulator, receiver
K529_RS13365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_RS13390	COG5002	protein histidine kinase activity
K529_RS13400	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K529_RS13410	COG1522	sequence-specific DNA binding
K529_RS13420	COG0456	acetyltransferase
K529_RS13430	COG0444	Belongs to the ABC transporter superfamily
K529_RS13435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS13440	COG0601	transmembrane transport
K529_RS13470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_RS13485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K529_RS13490	COG0251	oxidation-reduction process
K529_RS13495	COG0793	Belongs to the peptidase S41A family
K529_RS13505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K529_RS13520	COG1280	lysine exporter protein (LysE YggA)
K529_RS13530	COG1131	(ABC) transporter
K529_RS13540	COG0655	NAD(P)H dehydrogenase (quinone) activity
K529_RS13550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K529_RS13550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K529_RS13560	COG3622	Belongs to the hyi family
K529_RS13570	COG0714	Associated with various cellular activities
K529_RS13595	COG4953	penicillin-binding protein 1C
K529_RS13600	COG2373	Large extracellular alpha-helical protein
K529_RS13605	COG0784	Response regulator, receiver
K529_RS13605	COG5002	protein histidine kinase activity
K529_RS13605	COG2205	protein histidine kinase activity
K529_RS13610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K529_RS13620	COG0022	dehydrogenase e1 component
K529_RS13635	COG1522	sequence-specific DNA binding
K529_RS13650	COG0174	glutamine synthetase
K529_RS13685	COG0318	PFAM AMP-dependent synthetase and ligase
K529_RS13690	COG0183	Belongs to the thiolase family
K529_RS13695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K529_RS13720	COG1960	acyl-CoA dehydrogenase activity
K529_RS13740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K529_RS13745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K529_RS13750	COG0776	regulation of translation
K529_RS13760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K529_RS13765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K529_RS13775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K529_RS13785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K529_RS13800	COG1968	undecaprenyl-diphosphatase activity
K529_RS13820	COG1733	regulation of RNA biosynthetic process
K529_RS13830	COG0840	transmembrane signaling receptor activity
K529_RS13835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K529_RS13840	COG4143	(ABC) transporter
K529_RS13850	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K529_RS13875	COG3896	Chloramphenicol phosphotransferase-like protein
K529_RS13880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K529_RS13885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K529_RS13955	COG0840	transmembrane signaling receptor activity
K529_RS14030	COG0717	Belongs to the dCTP deaminase family
K529_RS14095	COG0653	protein targeting
K529_RS14115	COG0582	viral genome integration into host DNA
K529_RS14145	COG3727	T/G mismatch-specific endonuclease activity
K529_RS14220	COG1278	Cold shock
K529_RS14335	COG3772	lysozyme
K529_RS14355	COG1012	belongs to the aldehyde dehydrogenase family
K529_RS14380	COG4948	Mandelate Racemase Muconate Lactonizing
K529_RS14385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_RS14395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K529_RS14395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_RS14415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K529_RS14420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K529_RS14445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K529_RS14455	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K529_RS14465	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K529_RS14470	COG1999	signal sequence binding
K529_RS14480	COG2205	protein histidine kinase activity
K529_RS14485	COG0802	atpase or kinase
K529_RS14490	COG3178	'Phosphotransferase
K529_RS14495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K529_RS14505	COG1074	ATP-dependent DNA helicase activity
K529_RS14520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K529_RS14530	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K529_RS14555	COG3030	protein affecting phage T7 exclusion by the F plasmid
K529_RS14560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K529_RS14570	COG0237	dephospho-CoA kinase activity
K529_RS14575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K529_RS14580	COG0424	maF-like protein
K529_RS14585	COG1981	membrane
K529_RS14590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K529_RS14595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K529_RS14600	COG0445	tRNA wobble uridine modification
K529_RS14605	COG0357	Ribosomal RNA small subunit methyltransferase G
K529_RS14620	COG2832	Protein of unknown function (DUF454)
K529_RS14625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K529_RS14630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K529_RS14635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K529_RS14645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K529_RS14650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K529_RS14655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_RS14660	COG0281	malic enzyme
K529_RS14660	COG0280	phosphate acetyltransferase
K529_RS14670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K529_RS14690	COG0137	argininosuccinate synthase activity
K529_RS14700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K529_RS14710	COG0745	RESPONSE REGULATOR receiver
K529_RS14715	COG0494	nUDIX hydrolase
K529_RS14730	COG0617	tRNA 3'-terminal CCA addition
K529_RS14735	COG1132	(ABC) transporter
K529_RS14740	COG1132	(ABC) transporter
K529_RS14745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K529_RS14755	COG3034	peptidoglycan biosynthetic process
K529_RS14785	COG1040	competence protein
K529_RS14795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K529_RS14805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K529_RS14820	COG0779	Required for maturation of 30S ribosomal subunits
K529_RS14835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K529_RS14840	COG0494	nUDIX hydrolase
K529_RS14845	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K529_RS14850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K529_RS14855	COG0653	protein targeting
K529_RS14880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K529_RS14885	COG0142	geranyltranstransferase activity
K529_RS14890	COG1722	exodeoxyribonuclease VII activity
K529_RS14895	COG0123	including yeast histone deacetylase and acetoin utilization protein
K529_RS14905	COG0745	RESPONSE REGULATOR receiver
K529_RS14910	COG1846	Transcriptional regulator
K529_RS14915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K529_RS14920	COG1764	response to oxidative stress
K529_RS14925	COG1846	Transcriptional regulator
K529_RS14940	COG0789	Transcriptional regulator
K529_RS14955	COG4607	ABC-type enterochelin transport system periplasmic component
K529_RS14960	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_RS14965	COG4605	iron ion homeostasis
K529_RS14970	COG4604	ABC transporter, ATP-binding protein
K529_RS14985	COG4139	cobalamin transport
K529_RS14990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K529_RS14995	COG0840	transmembrane signaling receptor activity
K529_RS15000	COG1360	Flagellar Motor Protein
K529_RS15020	COG1706	bacterial-type flagellum-dependent cell motility
K529_RS15025	COG1338	Plays a role in the flagellum-specific transport system
K529_RS15030	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K529_RS15040	COG1766	The M ring may be actively involved in energy transduction
K529_RS15060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K529_RS15070	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K529_RS15075	COG1684	flagellar biosynthetic protein fliR
K529_RS15080	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K529_RS15095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K529_RS15105	COG4786	Flagellar basal body rod
K529_RS15110	COG4786	Flagellar basal body rod
K529_RS15115	COG1987	bacterial-type flagellum assembly
K529_RS15120	COG1677	Flagellar hook-basal body complex protein FliE
K529_RS15125	COG1558	bacterial-type flagellum-dependent cell motility
K529_RS15130	COG1815	bacterial-type flagellum-dependent cell motility
K529_RS15145	COG5443	negative regulation of bacterial-type flagellum assembly
K529_RS15155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_RS15175	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K529_RS15185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_RS15190	COG1177	transmembrane transport
K529_RS15195	COG1176	ABC-type spermidine putrescine transport system, permease component I
K529_RS15200	COG3842	ATPase activity
K529_RS15210	COG1802	Transcriptional regulator
K529_RS15220	COG3842	ATPase activity
K529_RS15230	COG1176	ABC-type spermidine putrescine transport system, permease component I
K529_RS15240	COG2951	lytic endotransglycosylase activity
K529_RS15245	COG2378	regulation of single-species biofilm formation
K529_RS15255	COG0557	exoribonuclease II activity
K529_RS15265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K529_RS15275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K529_RS15305	COG1228	amidohydrolase
K529_RS15310	COG2986	histidine ammonia-lyase
K529_RS15320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K529_RS15330	COG2171	N-acyltransferase activity
K529_RS15340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K529_RS15355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K529_RS15375	COG0560	Phosphoserine phosphatase
K529_RS15375	COG3830	Belongs to the UPF0237 family
K529_RS15380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K529_RS15385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K529_RS15390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K529_RS15395	COG1063	alcohol dehydrogenase
K529_RS15400	COG0156	8-amino-7-oxononanoate synthase activity
K529_RS15405	COG1396	sequence-specific DNA binding
K529_RS15410	COG0183	Belongs to the thiolase family
K529_RS15420	COG2226	methyltransferase
K529_RS15425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K529_RS15430	COG1024	Enoyl-CoA hydratase
K529_RS15435	COG0268	Binds directly to 16S ribosomal RNA
K529_RS15575	COG0583	DNA-binding transcription factor activity
K529_RS15580	COG0483	inositol monophosphate 1-phosphatase activity
K529_RS15595	COG1522	sequence-specific DNA binding
K529_RS15605	COG0628	permease
K529_RS15620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K529_RS15625	COG0028	Belongs to the TPP enzyme family
K529_RS15635	COG1802	Transcriptional regulator
K529_RS15640	COG0747	negative chemotaxis
K529_RS15645	COG0601	transmembrane transport
K529_RS15650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS15660	COG1609	Transcriptional regulator
K529_RS15670	COG1129	ABC transporter
K529_RS15675	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_RS15680	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_RS15690	COG1072	(Pantothenic acid kinase))
K529_RS15700	COG1294	oxidase, subunit
K529_RS15705	COG1271	oxidase subunit
K529_RS15785	COG0582	viral genome integration into host DNA
K529_RS15810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_RS15820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_RS15825	COG1917	Cupin 2, conserved barrel domain protein
K529_RS15835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K529_RS15840	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
K529_RS15855	COG0351	phosphomethylpyrimidine kinase
K529_RS15870	COG2022	thiamine diphosphate biosynthetic process
K529_RS15880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K529_RS15885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K529_RS15890	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K529_RS15895	COG1116	anion transmembrane transporter activity
K529_RS15900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K529_RS15910	COG1473	amidohydrolase
K529_RS15915	COG4172	Belongs to the ABC transporter superfamily
K529_RS15920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS15925	COG0601	transmembrane transport
K529_RS15930	COG0747	negative chemotaxis
K529_RS15945	COG1268	BioY protein
K529_RS15955	COG1122	ATPase activity
K529_RS15960	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K529_RS15965	COG4149	molybdate abc transporter
K529_RS15970	COG0725	ABC transporter, periplasmic molybdate-binding protein
K529_RS15975	COG1177	transmembrane transport
K529_RS15980	COG1176	ABC-type spermidine putrescine transport system, permease component I
K529_RS15985	COG3842	ATPase activity
K529_RS15990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K529_RS16035	COG3932	Exopolysaccharide synthesis, ExoD
K529_RS16065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS16070	COG0601	transmembrane transport
K529_RS16075	COG4166	transmembrane transport
K529_RS16080	COG3386	PFAM SMP-30 Gluconolaconase
K529_RS16085	COG0800	Aldolase
K529_RS16090	COG3734	2-keto-3-deoxy-galactonokinase
K529_RS16110	COG0129	dihydroxy-acid dehydratase activity
K529_RS16115	COG4214	carbohydrate transport
K529_RS16200	COG0697	spore germination
K529_RS16205	COG0473	3-isopropylmalate dehydrogenase activity
K529_RS16225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K529_RS16240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K529_RS16260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K529_RS16265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_RS16270	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_RS16275	COG1120	ATPase activity
K529_RS16285	COG0811	peptide transport
K529_RS16290	COG0848	biopolymer transport protein
K529_RS16315	COG1126	abc transporter atp-binding protein
K529_RS16325	COG1595	DNA-templated transcription, initiation
K529_RS16345	COG0626	cystathionine gamma-synthase activity
K529_RS16365	COG0583	DNA-binding transcription factor activity
K529_RS16370	COG4774	siderophore transport
K529_RS16380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_RS16385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_RS16495	COG2188	Transcriptional regulator
K529_RS16500	COG0583	DNA-binding transcription factor activity
K529_RS16510	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS16515	COG2814	Major facilitator Superfamily
K529_RS16520	COG1902	pentaerythritol trinitrate reductase activity
K529_RS16540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K529_RS16550	COG0583	DNA-binding transcription factor activity
K529_RS16555	COG1881	PFAM PEBP family protein
K529_RS16570	COG2207	Transcriptional regulator
K529_RS16575	COG1129	ABC transporter
K529_RS16580	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_RS16595	COG0579	oxidoreductase
K529_RS16625	COG3842	ATPase activity
K529_RS16635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K529_RS16640	COG3958	Transketolase
K529_RS16645	COG1802	Transcriptional regulator
K529_RS16650	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS16665	COG1176	ABC-type spermidine putrescine transport system, permease component I
K529_RS16700	COG1942	4-Oxalocrotonate Tautomerase
K529_RS16710	COG0625	glutathione transferase activity
K529_RS16715	COG0583	DNA-binding transcription factor activity
K529_RS16725	COG0604	alcohol dehydrogenase
K529_RS16740	COG0583	DNA-binding transcription factor activity
K529_RS16795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K529_RS16810	COG0330	HflC and HflK could
K529_RS16855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K529_RS16900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K529_RS16905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K529_RS16940	COG2951	lytic endotransglycosylase activity
K529_RS16945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K529_RS16950	COG1047	Peptidyl-prolyl cis-trans
K529_RS16970	COG0596	Alpha beta hydrolase
K529_RS16975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_RS16985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K529_RS16995	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K529_RS17000	COG4948	Mandelate Racemase Muconate Lactonizing
K529_RS17005	COG0640	Transcriptional regulator
K529_RS17010	COG0179	Fumarylacetoacetate (FAA) hydrolase
K529_RS17015	COG1132	(ABC) transporter
K529_RS17030	COG1522	sequence-specific DNA binding
K529_RS17050	COG0747	negative chemotaxis
K529_RS17055	COG0601	transmembrane transport
K529_RS17060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS17065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_RS17070	COG0668	transmembrane transport
K529_RS17090	COG0588	phosphoglycerate mutase activity
K529_RS17110	COG3454	Phosphonate metabolism
K529_RS17125	COG4778	phosphonate C-P lyase system protein PhnL
K529_RS17135	COG4107	phosphonate C-P lyase system protein PhnK
K529_RS17140	COG3627	carbon phosphorus lyase activity
K529_RS17145	COG3626	phosphonate metabolism
K529_RS17150	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
K529_RS17155	COG3624	Phosphonate C-P lyase system protein PhnG
K529_RS17160	COG2188	Transcriptional regulator
K529_RS17170	COG3639	organic phosphonate transmembrane transporter activity
K529_RS17175	COG3639	organic phosphonate transmembrane transporter activity
K529_RS17180	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
K529_RS17190	COG0583	DNA-binding transcription factor activity
K529_RS17195	COG0300	oxidoreductase activity
K529_RS17210	COG5441	Belongs to the UPF0261 family
K529_RS17240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K529_RS17250	COG0174	glutamine synthetase
K529_RS17260	COG0519	Catalyzes the synthesis of GMP from XMP
K529_RS17260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K529_RS17270	COG3396	Phenylacetate-CoA oxygenase
K529_RS17275	COG3460	Phenylacetate-CoA oxygenase
K529_RS17280	COG3396	Phenylacetate-CoA oxygenase
K529_RS17285	COG2151	metal-sulfur cluster biosynthetic enzyme
K529_RS17290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K529_RS17310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K529_RS17320	COG0456	acetyltransferase
K529_RS17325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K529_RS17350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K529_RS17350	COG3153	acetyltransferase
K529_RS17365	COG1530	ribonuclease E activity
K529_RS17370	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K529_RS17385	COG2132	Multicopper oxidase
K529_RS17395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K529_RS17410	COG2010	Cytochrome c
K529_RS17420	COG0714	Associated with various cellular activities
K529_RS17505	COG0494	nUDIX hydrolase
K529_RS17590	COG1280	lysine exporter protein (LysE YggA)
K529_RS17615	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K529_RS17620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K529_RS17660	COG0583	DNA-binding transcription factor activity
K529_RS17675	COG1960	acyl-CoA dehydrogenase activity
K529_RS17680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_RS17685	COG0583	DNA-binding transcription factor activity
K529_RS17705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K529_RS17765	COG0402	S-adenosylhomocysteine deaminase activity
K529_RS17775	COG0583	DNA-binding transcription factor activity
K529_RS17780	COG2351	hydroxyisourate hydrolase activity
K529_RS17790	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K529_RS17800	COG3257	ureidoglycine aminohydrolase activity
K529_RS17805	COG2379	hydroxypyruvate reductase
K529_RS17820	COG1012	belongs to the aldehyde dehydrogenase family
K529_RS17835	COG0179	Fumarylacetoacetate (FAA) hydrolase
K529_RS17840	COG3971	2-oxopent-4-enoate hydratase activity
K529_RS17865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K529_RS17875	COG0288	reversible hydration of carbon dioxide
K529_RS17885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K529_RS17890	COG0791	NLP P60 protein
K529_RS17905	COG1309	transcriptional regulator
K529_RS17910	COG0679	Auxin Efflux Carrier
K529_RS17915	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K529_RS17925	COG1671	Belongs to the UPF0178 family
K529_RS17940	COG3474	cytochrome
K529_RS17945	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K529_RS17955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K529_RS17980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS17995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K529_RS18000	COG0784	Response regulator, receiver
K529_RS18000	COG2198	Histidine kinase
K529_RS18000	COG5002	protein histidine kinase activity
K529_RS18005	COG1335	isochorismatase
K529_RS18010	COG1054	Belongs to the UPF0176 family
K529_RS18025	COG0012	GTP binding
K529_RS18035	COG0159	tryptophan synthase activity
K529_RS18040	COG2205	protein histidine kinase activity
K529_RS18040	COG0784	Response regulator, receiver
K529_RS18050	COG0738	Major facilitator superfamily
K529_RS18060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K529_RS18070	COG0193	aminoacyl-tRNA hydrolase activity
K529_RS18080	COG0004	ammonium transporteR
K529_RS18085	COG0133	tryptophan synthase activity
K529_RS18090	COG0583	DNA-binding transcription factor activity
K529_RS18095	COG0135	phosphoribosylanthranilate isomerase activity
K529_RS18105	COG0776	regulation of translation
K529_RS18110	COG3443	Belongs to the bacterial solute-binding protein 9 family
K529_RS18115	COG0539	negative regulation of cytoplasmic translation
K529_RS18125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K529_RS18145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K529_RS18155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K529_RS18160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K529_RS18165	COG1253	flavin adenine dinucleotide binding
K529_RS18170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K529_RS18180	COG1702	phosphate starvation-inducible protein PhoH
K529_RS18195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K529_RS18210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K529_RS18215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K529_RS18220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K529_RS18245	COG0587	DNA-directed DNA polymerase activity
K529_RS18250	COG3300	MHYT domain
K529_RS18250	COG5001	Diguanylate cyclase
K529_RS18265	COG0737	Belongs to the 5'-nucleotidase family
K529_RS18290	COG1335	isochorismatase
K529_RS18300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K529_RS18305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K529_RS18320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K529_RS18330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K529_RS18350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K529_RS18355	COG0028	Belongs to the TPP enzyme family
K529_RS18365	COG2855	membrane
K529_RS18370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K529_RS18375	COG1595	DNA-templated transcription, initiation
K529_RS18380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K529_RS18395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_RS18395	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K529_RS18410	COG0556	nucleotide-excision repair
K529_RS18510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K529_RS18540	COG4774	siderophore transport
K529_RS18545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K529_RS18550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_RS18580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K529_RS18595	COG1475	DNA binding
K529_RS18600	COG1192	Involved in chromosome partitioning
K529_RS18610	COG0318	PFAM AMP-dependent synthetase and ligase
K529_RS18625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_RS18625	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K529_RS18630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_RS18660	COG1805	sodium ion transport
K529_RS18670	COG1477	protein flavinylation
K529_RS18680	COG1063	alcohol dehydrogenase
K529_RS18685	COG3708	Transcriptional regulator
K529_RS18685	COG2207	Transcriptional regulator
K529_RS18690	COG1879	ABC-type sugar transport system periplasmic component
K529_RS18700	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_RS18715	COG0095	Lipoate-protein ligase
K529_RS18725	COG2011	ABC-type metal ion transport system permease component
K529_RS18730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K529_RS18760	COG1653	transport
K529_RS18765	COG0395	ABC-type sugar transport system, permease component
K529_RS18770	COG1175	transmembrane transport
K529_RS18785	COG3119	arylsulfatase activity
K529_RS18835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K529_RS18850	COG2176	DNA-directed DNA polymerase activity
K529_RS18850	COG5002	protein histidine kinase activity
K529_RS18855	COG0583	DNA-binding transcription factor activity
K529_RS18860	COG1960	acyl-CoA dehydrogenase activity
K529_RS18865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K529_RS18875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_RS18880	COG0183	Belongs to the thiolase family
K529_RS18885	COG1129	ABC transporter
K529_RS18890	COG4214	carbohydrate transport
K529_RS18895	COG4213	ABC transporter substrate-binding protein
K529_RS18930	COG1595	DNA-templated transcription, initiation
K529_RS18950	COG3384	dioxygenase
K529_RS18960	COG4948	Mandelate Racemase Muconate Lactonizing
K529_RS18970	COG2301	Belongs to the HpcH HpaI aldolase family
K529_RS18995	COG0825	malonyl-CoA metabolic process
K529_RS19010	COG1309	transcriptional regulator
K529_RS19020	COG0673	inositol 2-dehydrogenase activity
K529_RS19025	COG0395	ABC-type sugar transport system, permease component
K529_RS19030	COG1175	transmembrane transport
K529_RS19040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K529_RS19050	COG2188	Transcriptional regulator
K529_RS19055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K529_RS19060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K529_RS19065	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K529_RS19075	COG0243	molybdopterin cofactor binding
K529_RS19085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K529_RS19100	COG0747	negative chemotaxis
K529_RS19105	COG0747	negative chemotaxis
K529_RS19120	COG0444	Belongs to the ABC transporter superfamily
K529_RS19125	COG4608	Belongs to the ABC transporter superfamily
K529_RS19130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K529_RS19140	COG1902	pentaerythritol trinitrate reductase activity
K529_RS19140	COG0446	pyridine nucleotide-disulphide oxidoreductase
K529_RS19145	COG5001	Diguanylate cyclase
K529_RS19150	COG1858	cytochrome C peroxidase
K529_RS19155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K529_RS19170	COG2390	Transcriptional regulator
K529_RS19180	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_RS19190	COG1879	ABC-type sugar transport system periplasmic component
K529_RS19195	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS19195	COG3347	Dehydrogenase
K529_RS19200	COG3119	arylsulfatase activity
K529_RS19210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_RS19225	COG1609	Transcriptional regulator
K529_RS19245	COG3772	lysozyme
K529_RS19320	COG0740	serine-type endopeptidase activity
K529_RS19385	COG0629	single-stranded DNA binding
K529_RS19410	COG4974	Belongs to the 'phage' integrase family
K529_RS19465	COG3772	lysozyme
K529_RS19540	COG0667	Aldo Keto reductase
K529_RS19545	COG0583	DNA-binding transcription factor activity
K529_RS19550	COG0625	glutathione transferase activity
K529_RS19580	COG1686	Belongs to the peptidase S11 family
K529_RS19585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K529_RS19595	COG0084	hydrolase, TatD family'
K529_RS19600	COG1234	tRNA 3'-trailer cleavage
K529_RS19625	COG4608	Belongs to the ABC transporter superfamily
K529_RS19630	COG0444	Belongs to the ABC transporter superfamily
K529_RS19635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS19640	COG0601	transmembrane transport
K529_RS19645	COG0747	negative chemotaxis
K529_RS19655	COG3852	Histidine kinase
K529_RS19675	COG3639	organic phosphonate transmembrane transporter activity
K529_RS19690	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K529_RS19695	COG0252	asparaginase activity
K529_RS19700	COG1115	amino acid carrier protein
K529_RS19710	COG3848	Pyruvate phosphate dikinase
K529_RS19710	COG0574	Belongs to the PEP-utilizing enzyme family
K529_RS19725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K529_RS19745	COG3938	Belongs to the proline racemase family
K529_RS19750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K529_RS19755	COG3938	Belongs to the proline racemase family
K529_RS19760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K529_RS19775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_RS19780	COG0840	transmembrane signaling receptor activity
K529_RS19795	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K529_RS19800	COG3383	formate dehydrogenase (NAD+) activity
K529_RS19860	COG4774	siderophore transport
K529_RS19870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_RS19875	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K529_RS19880	COG1120	ATPase activity
K529_RS19885	COG0642	Histidine kinase
K529_RS19890	COG0745	RESPONSE REGULATOR receiver
K529_RS19910	COG4208	sulfate ABC transporter
K529_RS19915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K529_RS19925	COG3008	intermembrane lipid transfer
K529_RS19925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K529_RS19930	COG2995	paraquat-inducible protein a
K529_RS19935	COG2995	paraquat-inducible protein a
K529_RS19945	COG1115	amino acid carrier protein
K529_RS19955	COG1802	Transcriptional regulator
K529_RS19960	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K529_RS19970	COG1012	belongs to the aldehyde dehydrogenase family
K529_RS19980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K529_RS19995	COG2031	fatty acid transporter
K529_RS20000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K529_RS20005	COG3842	ATPase activity
K529_RS20020	COG1840	ABC-type Fe3 transport system, periplasmic component
K529_RS20025	COG1609	Transcriptional regulator
K529_RS20030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K529_RS20035	COG2723	6-phospho-beta-galactosidase activity
K529_RS20040	COG1609	Transcriptional regulator
K529_RS20045	COG1653	transport
K529_RS20050	COG1175	transmembrane transport
K529_RS20055	COG0395	ABC-type sugar transport system, permease component
K529_RS20060	COG0366	Alpha amylase catalytic
K529_RS20065	COG3842	ATPase activity
K529_RS20095	COG0745	RESPONSE REGULATOR receiver
K529_RS20100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K529_RS20115	COG0745	RESPONSE REGULATOR receiver
K529_RS20125	COG0840	transmembrane signaling receptor activity
K529_RS20130	COG2201	protein-glutamate methylesterase activity
K529_RS20140	COG1309	transcriptional regulator
K529_RS20150	COG0395	ABC-type sugar transport system, permease component
K529_RS20160	COG1653	transport
K529_RS20165	COG3842	ATPase activity
K529_RS20175	COG4638	Rieske (2fe-2S)
K529_RS20195	COG2204	response regulator
K529_RS20200	COG4251	negative regulation of phosphorylation
K529_RS20210	COG5002	protein histidine kinase activity
K529_RS20210	COG3850	Histidine kinase
K529_RS20220	COG1183	phosphatidylcholine synthase activity
K529_RS20240	COG0646	methionine synthase
K529_RS20240	COG1410	methionine synthase
K529_RS20260	COG1012	belongs to the aldehyde dehydrogenase family
K529_RS20275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K529_RS20275	COG0072	phenylalanine-tRNA ligase activity
K529_RS20285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K529_RS20310	COG0668	transmembrane transport
K529_RS20315	COG0686	Belongs to the AlaDH PNT family
K529_RS20320	COG1522	sequence-specific DNA binding
K529_RS20325	COG2326	polyphosphate kinase activity
K529_RS20330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K529_RS20340	COG0314	molybdopterin synthase activity
K529_RS20355	COG2885	chlorophyll binding
K529_RS20360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K529_RS20365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K529_RS20400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K529_RS20410	COG0540	Belongs to the ATCase OTCase family
K529_RS20415	COG1678	Uncharacterized ACR, COG1678
K529_RS20430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K529_RS20440	COG0521	Mo-molybdopterin cofactor biosynthetic process
K529_RS20445	COG1280	lysine exporter protein (LysE YggA)
K529_RS20455	COG1573	uracil-dna glycosylase
K529_RS20460	COG0009	L-threonylcarbamoyladenylate synthase
K529_RS20465	COG1960	acyl-CoA dehydrogenase activity
K529_RS20480	COG1914	H( )-stimulated, divalent metal cation uptake system
K529_RS20485	COG1321	iron dependent repressor
K529_RS20520	COG0746	molybdenum cofactor guanylyltransferase activity
K529_RS20540	COG0456	acetyltransferase
K529_RS20550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K529_RS20560	COG0789	Transcriptional regulator
K529_RS20575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K529_RS20580	COG0142	geranyltranstransferase activity
K529_RS20605	COG0583	DNA-binding transcription factor activity
K529_RS20610	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS20625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K529_RS20630	COG0165	Argininosuccinate lyase
K529_RS20635	COG0019	diaminopimelate decarboxylase activity
K529_RS20650	COG2884	Cell division ATP-binding protein ftsE
K529_RS20705	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_RS20715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K529_RS20730	COG0045	succinate-CoA ligase (ADP-forming) activity
K529_RS20745	COG0039	L-malate dehydrogenase activity
K529_RS20770	COG2030	dehydratase
K529_RS20840	COG0813	purine-nucleoside phosphorylase activity
K529_RS20850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K529_RS20850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K529_RS20855	COG2937	Belongs to the GPAT DAPAT family
K529_RS20860	COG0604	alcohol dehydrogenase
K529_RS20875	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS20885	COG0730	response to heat
K529_RS20890	COG1079	Belongs to the binding-protein-dependent transport system permease family
K529_RS20895	COG4603	Belongs to the binding-protein-dependent transport system permease family
K529_RS20900	COG3845	ABC transporter
K529_RS20905	COG1744	ABC transporter substrate-binding protein PnrA-like
K529_RS20915	COG1214	PFAM Peptidase M22, glycoprotease
K529_RS20925	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K529_RS21020	COG0321	lipoyl(octanoyl) transferase activity
K529_RS21025	COG3842	ATPase activity
K529_RS21035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K529_RS21050	COG2182	Extracellular solute-binding protein
K529_RS21075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K529_RS21090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K529_RS21105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K529_RS21115	COG0439	Biotin carboxylase
K529_RS21125	COG1984	allophanate hydrolase subunit 2
K529_RS21130	COG1879	ABC-type sugar transport system periplasmic component
K529_RS21135	COG1129	ABC transporter
K529_RS21140	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_RS21150	COG3181	Tripartite tricarboxylate transporter family receptor
K529_RS21165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K529_RS21200	COG0517	IMP dehydrogenase activity
K529_RS21205	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K529_RS21235	COG0187	DNA topoisomerase II activity
K529_RS21260	COG0534	Mate efflux family protein
K529_RS21285	COG1846	Transcriptional regulator
K529_RS21295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K529_RS21305	COG1278	Cold shock
K529_RS21310	COG1393	Belongs to the ArsC family
K529_RS21325	COG3220	belongs to the UPF0276 family
K529_RS21335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K529_RS21365	COG3243	poly(R)-hydroxyalkanoic acid synthase
K529_RS21410	COG0525	valine-tRNA ligase activity
K529_RS21440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K529_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS21490	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_RS21495	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_RS21500	COG1129	ABC transporter
K529_RS21510	COG0559	Belongs to the binding-protein-dependent transport system permease family
K529_RS21515	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_RS21530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K529_RS21530	COG1017	nitric oxide dioxygenase activity
K529_RS21545	COG4608	Belongs to the ABC transporter superfamily
K529_RS21550	COG0747	negative chemotaxis
K529_RS21555	COG0601	transmembrane transport
K529_RS21560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS21565	COG0405	Gamma-glutamyltransferase
K529_RS21575	COG2186	Transcriptional regulator
K529_RS21585	COG0444	Belongs to the ABC transporter superfamily
K529_RS21590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K529_RS21595	COG0601	transmembrane transport
K529_RS21605	COG1233	COG1233 Phytoene dehydrogenase and related
K529_RS21610	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K529_RS21640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K529_RS21650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K529_RS21660	COG1215	transferase activity, transferring glycosyl groups
K529_RS21665	COG1215	transferase activity, transferring glycosyl groups
K529_RS21670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K529_RS21690	COG1414	Transcriptional regulator
K529_RS21695	COG1475	DNA binding
K529_RS21700	COG1192	Involved in chromosome partitioning
K529_RS21705	COG0583	DNA-binding transcription factor activity
K529_RS21775	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS21780	COG1028	Short-chain dehydrogenase reductase Sdr
K529_RS21785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K529_RS21790	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K529_RS21795	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_RS21800	COG0022	dehydrogenase e1 component
K529_RS21800	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_RS21805	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K529_RS21810	COG1172	Belongs to the binding-protein-dependent transport system permease family
K529_RS21815	COG1129	ABC transporter
K529_RS21830	COG0402	S-adenosylhomocysteine deaminase activity
K529_RS21845	COG3845	ABC transporter
K529_RS21850	COG4603	Belongs to the binding-protein-dependent transport system permease family
K529_RS21855	COG1079	Belongs to the binding-protein-dependent transport system permease family
K529_RS21860	COG2358	TRAP transporter, solute receptor (TAXI family
K529_RS21865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_RS21870	COG0415	Belongs to the DNA photolyase family
K529_RS21895	COG4172	Belongs to the ABC transporter superfamily
K529_RS21915	COG1720	tRNA m6t6A37 methyltransferase activity
K529_RS21980	COG0596	Alpha beta hydrolase
K529_RS22010	COG0318	PFAM AMP-dependent synthetase and ligase
K529_RS22020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K529_RS22030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K529_RS22040	COG1136	(ABC) transporter
K529_RS22055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K529_RS22075	COG3708	Transcriptional regulator
K529_RS22075	COG2207	Transcriptional regulator
K529_RS22085	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_RS22095	COG0508	dehydrogenase complex catalyzes the overall conversion of
K529_RS22100	COG0022	dehydrogenase e1 component
K529_RS22105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K529_RS22140	COG4232	protein-disulfide reductase activity
K529_RS22160	COG2217	Heavy metal translocating P-type atpase
K529_RS22170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K529_RS22170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K529_RS22180	COG2132	Multicopper oxidase
K529_RS22205	COG1376	ErfK ybiS ycfS ynhG family protein
K529_RS22235	COG4235	cytochrome complex assembly
K529_RS22240	COG3088	subunit of a heme lyase
K529_RS22245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K529_RS22250	COG1138	Cytochrome C-type biogenesis protein
K529_RS22265	COG2132	Multicopper oxidase
K529_RS22295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K529_RS22320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K529_RS22350	COG0798	PFAM Bile acid sodium symporter
K529_RS22360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K529_RS22365	COG1192	Involved in chromosome partitioning
K529_RS22490	COG0789	Transcriptional regulator
K529_RS22495	COG1999	signal sequence binding
K529_RS22505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K529_RS22515	COG1999	signal sequence binding
K529_RS22540	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K529_RS22545	COG2366	antibiotic biosynthetic process
K529_RS22555	COG1321	iron dependent repressor
K529_RS22570	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K529_RS22580	COG3034	peptidoglycan biosynthetic process
K529_RS22625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K529_RS22630	COG2124	cytochrome p450
K529_RS22645	COG0785	Cytochrome C biogenesis protein
K529_RS22665	COG1999	signal sequence binding
K529_RS22670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K529_RS22670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K529_RS22685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K529_RS22690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K529_RS22710	COG2132	Multicopper oxidase
K529_RS22725	COG4941	Belongs to the sigma-70 factor family
K529_RS22730	COG3795	YCII-related domain
K529_RS22740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K529_RS22740	COG0517	IMP dehydrogenase activity
K529_RS22770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K529_RS22830	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K529_RS22845	COG1192	Involved in chromosome partitioning
K529_RS22940	COG1088	dTDP-glucose 4,6-dehydratase activity
K529_RS22950	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K529_RS22960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K529_RS23040	COG0346	lactoylglutathione lyase activity
K529_RS23080	COG5487	UPF0391 membrane protein
K529_RS23185	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K529_RS23205	COG1012	belongs to the aldehyde dehydrogenase family
K529_RS23295	COG0735	belongs to the Fur family
K529_RS23785	COG4650	regulator
K529_RS23810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K529_RS23815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K529_RS23820	COG2197	response regulator
K529_RS23935	COG0582	viral genome integration into host DNA