locus-tag	class	description
TW_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TW_RS00010	COG0592	DNA-directed DNA polymerase activity
TW_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TW_RS00025	COG0187	DNA topoisomerase II activity
TW_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TW_RS00050	COG1564	THIamine pyrophosphokinase
TW_RS00070	COG1704	LemA family
TW_RS00095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TW_RS00110	COG4770	biotin carboxylase activity
TW_RS00130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TW_RS00170	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TW_RS00205	COG1216	Glycosyl transferase, family 2
TW_RS00255	COG0745	RESPONSE REGULATOR receiver
TW_RS00260	COG1278	Cold shock
TW_RS00275	COG0287	Prephenate dehydrogenase
TW_RS00280	COG1160	GTP binding
TW_RS00285	COG1169	isochorismate synthase
TW_RS00290	COG2226	methyltransferase
TW_RS00295	COG0142	geranyltranstransferase activity
TW_RS00315	COG1120	ATPase activity
TW_RS00320	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TW_RS00325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TW_RS00340	COG0640	Transcriptional regulator
TW_RS00350	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TW_RS00355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TW_RS00365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TW_RS00385	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TW_RS00420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TW_RS00430	COG0516	GMP reductase activity
TW_RS00465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TW_RS00470	COG0138	bifunctional purine biosynthesis protein purh
TW_RS00490	COG0750	zinc metalloprotease
TW_RS00500	COG0631	protein serine/threonine phosphatase activity
TW_RS00525	COG1131	(ABC) transporter
TW_RS00550	COG4974	Belongs to the 'phage' integrase family
TW_RS00615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TW_RS00635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TW_RS00655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TW_RS00660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TW_RS00665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TW_RS00670	COG0776	regulation of translation
TW_RS00680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TW_RS00690	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
TW_RS00695	COG1482	cell wall glycoprotein biosynthetic process
TW_RS00720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TW_RS00730	COG0653	protein targeting
TW_RS00775	COG1122	ATPase activity
TW_RS00780	COG0601	transmembrane transport
TW_RS00785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TW_RS00825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TW_RS00830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TW_RS00835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TW_RS00925	COG1132	(ABC) transporter
TW_RS00930	COG1132	(ABC) transporter
TW_RS00950	COG1217	gtp-binding protein TYPA
TW_RS00955	COG0802	atpase or kinase
TW_RS00960	COG1214	PFAM Peptidase M22, glycoprotease
TW_RS00960	COG0456	acetyltransferase
TW_RS00965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TW_RS00975	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TW_RS00980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TW_RS00985	COG0302	gtp cyclohydrolase
TW_RS00990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TW_RS01000	COG1137	ATPase activity
TW_RS01010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TW_RS01015	COG0196	riboflavin kinase activity
TW_RS01055	COG4122	O-methyltransferase activity
TW_RS01085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TW_RS01095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TW_RS01100	COG0571	ribonuclease III activity
TW_RS01135	COG0051	transcription antitermination factor activity, RNA binding
TW_RS01140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TW_RS01150	COG0089	rRNA binding
TW_RS01155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TW_RS01160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TW_RS01165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TW_RS01170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TW_RS01175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TW_RS01185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TW_RS01190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TW_RS01195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TW_RS01200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TW_RS01205	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TW_RS01210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TW_RS01215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TW_RS01220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TW_RS01225	COG1841	ribosomal large subunit assembly
TW_RS01240	COG0563	adenylate kinase activity
TW_RS01250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TW_RS01255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TW_RS01260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TW_RS01265	COG0202	RNA polymerase activity
TW_RS01270	COG0203	ribosomal protein L17
TW_RS01290	COG2239	Acts as a magnesium transporter
TW_RS01295	COG0006	proline dipeptidase activity
TW_RS01315	COG0210	DNA helicase
TW_RS01335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TW_RS01340	COG1799	cell septum assembly
TW_RS01345	COG3599	regulation of cell shape
TW_RS01370	COG0861	Integral membrane protein TerC family
TW_RS01375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TW_RS01380	COG0204	Acyl-transferase
TW_RS01385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TW_RS01400	COG0508	dehydrogenase complex catalyzes the overall conversion of
TW_RS01405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TW_RS01410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TW_RS01415	COG0752	glycyl-tRNA synthetase alpha subunit
TW_RS01415	COG0751	glycine-tRNA ligase activity
TW_RS01420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TW_RS01435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TW_RS01440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TW_RS01445	COG0187	DNA topoisomerase II activity
TW_RS01460	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TW_RS01465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TW_RS01485	COG0756	dUTP diphosphatase activity
TW_RS01500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TW_RS01515	COG0544	peptidyl-prolyl cis-trans isomerase activity
TW_RS01525	COG0740	serine-type endopeptidase activity
TW_RS01530	COG0740	serine-type endopeptidase activity
TW_RS01545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TW_RS01550	COG0285	dihydrofolate synthase activity
TW_RS01560	COG0105	UTP biosynthetic process
TW_RS01565	COG1530	ribonuclease E activity
TW_RS01620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TW_RS01625	COG0321	lipoyl(octanoyl) transferase activity
TW_RS01630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TW_RS01640	COG1837	Belongs to the UPF0109 family
TW_RS01645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TW_RS01655	COG0335	large ribosomal subunit rRNA binding
TW_RS01680	COG0758	DNA mediated transformation
TW_RS01685	COG4974	Belongs to the 'phage' integrase family
TW_RS01700	COG0052	Belongs to the universal ribosomal protein uS2 family
TW_RS01710	COG0528	UMP kinase activity
TW_RS01715	COG0233	cytoplasmic translational termination
TW_RS01720	COG0575	Belongs to the CDS family
TW_RS01755	COG0460	homoserine dehydrogenase
TW_RS01760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TW_RS01765	COG0083	homoserine kinase activity
TW_RS01775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TW_RS01780	COG2890	protein-(glutamine-N5) methyltransferase activity
TW_RS01790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TW_RS01800	COG0356	it plays a direct role in the translocation of protons across the membrane
TW_RS01805	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TW_RS01810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TW_RS01815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TW_RS01820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TW_RS01825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TW_RS01830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TW_RS01835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TW_RS01840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TW_RS01845	COG1185	polyribonucleotide nucleotidyltransferase activity
TW_RS01870	COG1104	cysteine desulfurase activity
TW_RS01885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TW_RS01910	COG3845	ABC transporter
TW_RS01940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TW_RS01950	COG0629	single-stranded DNA binding
TW_RS01975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TW_RS01995	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TW_RS02055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TW_RS02065	COG1596	polysaccharide export
TW_RS02065	COG1555	photosystem II stabilization
TW_RS02095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TW_RS02105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TW_RS02110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TW_RS02120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TW_RS02125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TW_RS02130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TW_RS02140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TW_RS02145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TW_RS02150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TW_RS02155	COG0505	Belongs to the CarA family
TW_RS02160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TW_RS02165	COG0284	orotidine-5'-phosphate decarboxylase activity
TW_RS02175	COG1758	RNA polymerase activity
TW_RS02195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TW_RS02210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TW_RS02215	COG0573	inorganic phosphate transmembrane transporter activity
TW_RS02235	COG0018	arginyl-trna synthetase
TW_RS02245	COG1329	Transcriptional regulator
TW_RS02250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TW_RS02250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TW_RS02255	COG0215	cysteine-tRNA ligase activity
TW_RS02260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TW_RS02290	COG0166	Belongs to the GPI family
TW_RS02295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TW_RS02305	COG0109	protoheme IX farnesyltransferase activity
TW_RS02310	COG1612	heme a metabolic process
TW_RS02315	COG0719	Fe-S assembly protein
TW_RS02330	COG0396	ATPase activity
TW_RS02335	COG2151	metal-sulfur cluster biosynthetic enzyme
TW_RS02360	COG4214	carbohydrate transport
TW_RS02365	COG4213	ABC transporter substrate-binding protein
TW_RS02375	COG1063	alcohol dehydrogenase
TW_RS02380	COG0084	hydrolase, TatD family'
TW_RS02400	COG0805	protein transport
TW_RS02425	COG0215	cysteine-tRNA ligase activity
TW_RS02440	COG0254	rRNA binding
TW_RS02445	COG1028	Short-chain dehydrogenase reductase Sdr
TW_RS02450	COG0438	transferase activity, transferring glycosyl groups
TW_RS02470	COG0363	glucosamine-6-phosphate deaminase activity
TW_RS02475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TW_RS02505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TW_RS02535	COG0237	dephospho-CoA kinase activity
TW_RS02545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TW_RS02545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TW_RS02560	COG0469	pyruvate kinase activity
TW_RS02570	COG0791	NLP P60 protein
TW_RS02585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TW_RS02590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TW_RS02595	COG1381	Involved in DNA repair and RecF pathway recombination
TW_RS02600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TW_RS02605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TW_RS02610	COG0537	adenosine 5'-monophosphoramidase activity
TW_RS02615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TW_RS02635	COG0268	Binds directly to 16S ribosomal RNA
TW_RS02640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TW_RS02650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TW_RS02655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TW_RS02670	COG0632	four-way junction helicase activity
TW_RS02675	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TW_RS02680	COG0217	transcriptional regulatory protein
TW_RS02725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TW_RS02740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TW_RS02750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TW_RS02755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TW_RS02760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TW_RS02770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TW_RS02775	COG0723	plastoquinol--plastocyanin reductase activity
TW_RS02780	COG2010	Cytochrome c
TW_RS02785	COG1845	cytochrome c oxidase, subunit III
TW_RS02795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TW_RS02800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TW_RS02820	COG0328	RNA-DNA hybrid ribonuclease activity
TW_RS02825	COG0167	dihydroorotate dehydrogenase activity
TW_RS02830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TW_RS02870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TW_RS02875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TW_RS02880	COG0772	Belongs to the SEDS family
TW_RS02895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TW_RS02900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TW_RS02915	COG0275	rRNA processing
TW_RS02935	COG0142	geranyltranstransferase activity
TW_RS02940	COG0515	serine threonine protein kinase
TW_RS02940	COG2815	serine threonine protein kinase
TW_RS02945	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TW_RS02955	COG1940	carbohydrate kinase activity
TW_RS02965	COG1268	BioY protein
TW_RS02980	COG0492	ferredoxin-NADP+ reductase activity
TW_RS02985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TW_RS02990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TW_RS03000	COG0440	acetolactate synthase activity
TW_RS03050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TW_RS03065	COG2177	Part of the ABC transporter FtsEX involved in
TW_RS03070	COG2884	Cell division ATP-binding protein ftsE
TW_RS03075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TW_RS03105	COG0540	Belongs to the ATCase OTCase family
TW_RS03200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TW_RS03205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TW_RS03225	COG0534	Mate efflux family protein
TW_RS03235	COG1131	(ABC) transporter
TW_RS03295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TW_RS03315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TW_RS03320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TW_RS03325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TW_RS03360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TW_RS03370	COG0343	queuine tRNA-ribosyltransferase activity
TW_RS03410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TW_RS03420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TW_RS03440	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TW_RS03480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TW_RS03515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TW_RS03540	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TW_RS03545	COG1192	Involved in chromosome partitioning
TW_RS03570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TW_RS03575	COG0742	ribosomal rna small subunit methyltransferase
TW_RS03580	COG0509	glycine decarboxylation via glycine cleavage system
TW_RS03585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TW_RS03590	COG0012	GTP binding
TW_RS03605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TW_RS03610	COG1570	exodeoxyribonuclease VII activity
TW_RS03615	COG1722	exodeoxyribonuclease VII activity
TW_RS03620	COG2271	Major facilitator Superfamily
TW_RS03670	COG0588	phosphoglycerate mutase activity
TW_RS03700	COG1970	mechanosensitive ion channel activity
TW_RS03705	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
TW_RS03710	COG1121	(ABC) transporter
TW_RS03715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TW_RS03760	COG0049	tRNA binding
TW_RS03765	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TW_RS03780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TW_RS03785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TW_RS03790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TW_RS03795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TW_RS03795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TW_RS03820	COG0307	riboflavin synthase, alpha
TW_RS03825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TW_RS03825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TW_RS03835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TW_RS03840	COG1335	isochorismatase
TW_RS03855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TW_RS03860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TW_RS03865	COG1754	DNA topoisomerase type I activity
TW_RS03865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TW_RS03895	COG0251	oxidation-reduction process
TW_RS03900	COG4499	WXG100 protein secretion system (Wss), protein YukC
TW_RS03900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TW_RS03920	COG0527	aspartate kinase activity
TW_RS03940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TW_RS03945	COG0081	regulation of translation
TW_RS03950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TW_RS03960	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TW_RS03970	COG0436	Aminotransferase
TW_RS03985	COG2030	dehydratase
TW_RS03995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TW_RS04005	COG0151	Belongs to the GarS family
TW_RS04050	COG0181	hydroxymethylbilane synthase activity
TW_RS04055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TW_RS04060	COG3253	May function as heme-dependent peroxidase
TW_RS04065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TW_RS04070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TW_RS04075	COG4948	Mandelate Racemase Muconate Lactonizing
TW_RS04080	COG0305	Participates in initiation and elongation during chromosome replication
TW_RS04105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TW_RS04110	COG0708	Exodeoxyribonuclease III
TW_RS04120	COG0542	response to heat
TW_RS04125	COG0789	Transcriptional regulator
TW_RS04140	COG0443	Heat shock 70 kDa protein
TW_RS04145	COG0590	tRNA wobble adenosine to inosine editing
TW_RS04160	COG0017	Asparaginyl-tRNA synthetase
TW_RS04165	COG0406	alpha-ribazole phosphatase activity
TW_RS04170	COG3118	belongs to the thioredoxin family
TW_RS04175	COG0785	Cytochrome C biogenesis protein
TW_RS04180	COG1333	cytochrome c biogenesis protein
TW_RS04185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TW_RS04195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TW_RS04200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TW_RS04210	COG0463	Glycosyl transferase, family 2
TW_RS04230	COG3590	peptidase
TW_RS04235	COG0546	phosphoglycolate phosphatase activity
TW_RS04270	COG0768	penicillin binding
TW_RS04275	COG0515	serine threonine protein kinase
TW_RS04280	COG2815	serine threonine protein kinase
TW_RS04280	COG0515	serine threonine protein kinase
TW_RS04305	COG0148	phosphopyruvate hydratase activity
TW_RS04315	COG0124	histidyl-tRNA synthetase
TW_RS04325	COG0717	Belongs to the dCTP deaminase family
TW_RS04335	COG0508	dehydrogenase complex catalyzes the overall conversion of
TW_RS04340	COG0022	dehydrogenase e1 component
TW_RS04355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TW_RS04365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TW_RS04370	COG0047	phosphoribosylformylglycinamidine synthase activity
TW_RS04405	COG1192	Involved in chromosome partitioning
TW_RS04410	COG2217	Heavy metal translocating P-type atpase
TW_RS04425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TW_RS04430	COG0594	ribonuclease P activity
TW_RS04460	COG0194	GDP metabolic process
TW_RS04465	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA