locus-tag	class	description
TRAD_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TRAD_RS00015	COG0148	phosphopyruvate hydratase activity
TRAD_RS00025	COG0359	binds to the 23S rRNA
TRAD_RS00030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TRAD_RS00035	COG0629	single-stranded DNA binding
TRAD_RS00040	COG0360	Binds together with S18 to 16S ribosomal RNA
TRAD_RS00055	COG0443	Heat shock 70 kDa protein
TRAD_RS00060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TRAD_RS00065	COG0484	heat shock protein binding
TRAD_RS00085	COG1331	Highly conserved protein containing a thioredoxin domain
TRAD_RS00105	COG0335	large ribosomal subunit rRNA binding
TRAD_RS00115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TRAD_RS00120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TRAD_RS00125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TRAD_RS00130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TRAD_RS00150	COG0792	nuclease activity
TRAD_RS00155	COG0135	phosphoribosylanthranilate isomerase activity
TRAD_RS00160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TRAD_RS00175	COG2151	metal-sulfur cluster biosynthetic enzyme
TRAD_RS00180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TRAD_RS00185	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TRAD_RS00210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TRAD_RS00215	COG0640	Transcriptional regulator
TRAD_RS00230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TRAD_RS00235	COG2894	cell division
TRAD_RS00240	COG0210	DNA helicase
TRAD_RS00250	COG2389	metal-binding protein
TRAD_RS00260	COG3842	ATPase activity
TRAD_RS00275	COG2358	TRAP transporter, solute receptor (TAXI family
TRAD_RS00290	COG1960	acyl-CoA dehydrogenase activity
TRAD_RS00300	COG3153	acetyltransferase
TRAD_RS00300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TRAD_RS00305	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TRAD_RS00305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TRAD_RS00310	COG2423	ornithine cyclodeaminase activity
TRAD_RS00315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TRAD_RS00320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TRAD_RS00325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TRAD_RS00340	COG0336	Belongs to the RNA methyltransferase TrmD family
TRAD_RS00345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TRAD_RS00355	COG0228	four-way junction DNA binding
TRAD_RS00385	COG0138	bifunctional purine biosynthesis protein purh
TRAD_RS00420	COG1166	arginine decarboxylase activity
TRAD_RS00430	COG0598	Magnesium transport protein CorA
TRAD_RS00435	COG0542	response to heat
TRAD_RS00440	COG0107	imidazoleglycerol-phosphate synthase activity
TRAD_RS00455	COG0626	cystathionine gamma-synthase activity
TRAD_RS00535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TRAD_RS00550	COG0523	cobalamin synthesis protein
TRAD_RS00585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TRAD_RS00590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TRAD_RS00640	COG1176	ABC-type spermidine putrescine transport system, permease component I
TRAD_RS00645	COG1177	transmembrane transport
TRAD_RS00670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TRAD_RS00685	COG1874	Beta-galactosidase
TRAD_RS00685	COG0366	Alpha amylase catalytic
TRAD_RS00690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TRAD_RS00695	COG0019	diaminopimelate decarboxylase activity
TRAD_RS00700	COG0446	pyridine nucleotide-disulphide oxidoreductase
TRAD_RS00710	COG1012	belongs to the aldehyde dehydrogenase family
TRAD_RS00720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TRAD_RS00725	COG0546	phosphoglycolate phosphatase activity
TRAD_RS00730	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TRAD_RS00750	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS00760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TRAD_RS00775	COG3118	belongs to the thioredoxin family
TRAD_RS00780	COG0402	S-adenosylhomocysteine deaminase activity
TRAD_RS00795	COG4636	protein conserved in cyanobacteria
TRAD_RS00800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TRAD_RS00810	COG0601	transmembrane transport
TRAD_RS00815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS00825	COG4608	Belongs to the ABC transporter superfamily
TRAD_RS00835	COG1069	ribulokinase activity
TRAD_RS00840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TRAD_RS00845	COG0456	acetyltransferase
TRAD_RS00850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TRAD_RS00865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TRAD_RS00890	COG0736	holo-[acyl-carrier-protein] synthase activity
TRAD_RS00895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TRAD_RS00910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TRAD_RS00915	COG2086	electron transfer activity
TRAD_RS00920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TRAD_RS00925	COG2181	nitrate reductase activity
TRAD_RS00925	COG0247	lactate metabolic process
TRAD_RS00930	COG1472	Belongs to the glycosyl hydrolase 3 family
TRAD_RS00940	COG1482	cell wall glycoprotein biosynthetic process
TRAD_RS00945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TRAD_RS00955	COG1132	(ABC) transporter
TRAD_RS00975	COG3273	potassium ion transport
TRAD_RS00975	COG0471	metal ion transport
TRAD_RS00985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TRAD_RS00995	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TRAD_RS01020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TRAD_RS01025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TRAD_RS01030	COG2738	Putative neutral zinc metallopeptidase
TRAD_RS01035	COG2359	stage V sporulation protein S
TRAD_RS01040	COG0028	Belongs to the TPP enzyme family
TRAD_RS01045	COG0440	acetolactate synthase activity
TRAD_RS01050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TRAD_RS01055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TRAD_RS01060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TRAD_RS01065	COG0067	glutamate synthase
TRAD_RS01065	COG0069	glutamate synthase activity
TRAD_RS01065	COG0070	glutamate synthase
TRAD_RS01080	COG1063	alcohol dehydrogenase
TRAD_RS01095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TRAD_RS01100	COG2197	response regulator
TRAD_RS01110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TRAD_RS01115	COG3546	catalase activity
TRAD_RS01125	COG0408	coproporphyrinogen oxidase activity
TRAD_RS01130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TRAD_RS01135	COG0745	RESPONSE REGULATOR receiver
TRAD_RS01145	COG0113	porphobilinogen synthase activity
TRAD_RS01160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TRAD_RS01175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TRAD_RS01180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TRAD_RS01195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TRAD_RS01205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TRAD_RS01215	COG1803	Methylglyoxal synthase
TRAD_RS01235	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TRAD_RS01240	COG0569	domain protein
TRAD_RS01245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TRAD_RS01260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TRAD_RS01265	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
TRAD_RS01265	COG2066	Belongs to the glutaminase family
TRAD_RS01275	COG1404	Belongs to the peptidase S8 family
TRAD_RS01285	COG2258	MOSC domain
TRAD_RS01295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TRAD_RS01300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TRAD_RS01310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TRAD_RS01320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TRAD_RS01340	COG0719	Fe-S assembly protein
TRAD_RS01360	COG0396	ATPase activity
TRAD_RS01365	COG2815	serine threonine protein kinase
TRAD_RS01365	COG0515	serine threonine protein kinase
TRAD_RS01370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TRAD_RS01375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TRAD_RS01375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TRAD_RS01400	COG0514	ATP-dependent DNA helicase (RecQ)
TRAD_RS01405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TRAD_RS01405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TRAD_RS01415	COG1115	amino acid carrier protein
TRAD_RS01420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TRAD_RS01465	COG1999	signal sequence binding
TRAD_RS01470	COG1090	epimerase
TRAD_RS01480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TRAD_RS01490	COG1983	PspC domain protein
TRAD_RS01495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TRAD_RS01500	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TRAD_RS01520	COG1175	transmembrane transport
TRAD_RS01535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TRAD_RS01545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TRAD_RS01585	COG1132	(ABC) transporter
TRAD_RS01595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TRAD_RS01600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TRAD_RS01610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TRAD_RS01635	COG0802	atpase or kinase
TRAD_RS01650	COG0194	GDP metabolic process
TRAD_RS01655	COG1758	RNA polymerase activity
TRAD_RS01660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TRAD_RS01665	COG1438	arginine binding
TRAD_RS01690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TRAD_RS01700	COG4712	double-strand break repair protein
TRAD_RS01710	COG0181	hydroxymethylbilane synthase activity
TRAD_RS01715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TRAD_RS01735	COG1733	regulation of RNA biosynthetic process
TRAD_RS01740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TRAD_RS01750	COG0705	Rhomboid family
TRAD_RS01750	COG0457	Tetratricopeptide repeat
TRAD_RS01760	COG1120	ATPase activity
TRAD_RS01785	COG0302	gtp cyclohydrolase
TRAD_RS01795	COG0783	Belongs to the Dps family
TRAD_RS01805	COG0561	phosphatase activity
TRAD_RS01810	COG2009	succinate dehydrogenase
TRAD_RS01820	COG1053	succinate dehydrogenase
TRAD_RS01825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TRAD_RS01830	COG2239	Acts as a magnesium transporter
TRAD_RS01845	COG1968	undecaprenyl-diphosphatase activity
TRAD_RS01850	COG0251	oxidation-reduction process
TRAD_RS01860	COG0154	amidase activity
TRAD_RS01865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TRAD_RS01875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TRAD_RS01895	COG0590	tRNA wobble adenosine to inosine editing
TRAD_RS01905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TRAD_RS01915	COG0406	alpha-ribazole phosphatase activity
TRAD_RS01920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TRAD_RS01925	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TRAD_RS01940	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TRAD_RS01945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TRAD_RS01950	COG2890	protein-(glutamine-N5) methyltransferase activity
TRAD_RS01955	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TRAD_RS01960	COG2902	Dehydrogenase
TRAD_RS01965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TRAD_RS01975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TRAD_RS01980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TRAD_RS01990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TRAD_RS02025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TRAD_RS02025	COG0617	tRNA 3'-terminal CCA addition
TRAD_RS02025	COG3620	sequence-specific DNA binding
TRAD_RS02030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TRAD_RS02035	COG1994	Peptidase M50
TRAD_RS02035	COG0517	IMP dehydrogenase activity
TRAD_RS02040	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TRAD_RS02045	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TRAD_RS02050	COG0750	zinc metalloprotease
TRAD_RS02055	COG0463	Glycosyl transferase, family 2
TRAD_RS02060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TRAD_RS02090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TRAD_RS02100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TRAD_RS02115	COG4133	protoheme IX ABC transporter activity
TRAD_RS02120	COG0785	Cytochrome C biogenesis protein
TRAD_RS02165	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TRAD_RS02200	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TRAD_RS02205	COG1660	Displays ATPase and GTPase activities
TRAD_RS02215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TRAD_RS02220	COG0131	Imidazoleglycerol-phosphate dehydratase
TRAD_RS02225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TRAD_RS02235	COG0295	cytidine deaminase activity
TRAD_RS02240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TRAD_RS02245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TRAD_RS02250	COG1480	7TM receptor with intracellular HD hydrolase
TRAD_RS02255	COG1702	phosphate starvation-inducible protein PhoH
TRAD_RS02265	COG4864	UPF0365 protein
TRAD_RS02270	COG1030	water channel activity
TRAD_RS02285	COG1070	Carbohydrate kinase
TRAD_RS02295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TRAD_RS02300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TRAD_RS02310	COG0006	proline dipeptidase activity
TRAD_RS02315	COG0149	triose-phosphate isomerase activity
TRAD_RS02325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TRAD_RS02330	COG0018	arginyl-trna synthetase
TRAD_RS02345	COG0277	FAD linked oxidase domain protein
TRAD_RS02345	COG0247	lactate metabolic process
TRAD_RS02360	COG1175	transmembrane transport
TRAD_RS02365	COG0395	ABC-type sugar transport system, permease component
TRAD_RS02380	COG0673	inositol 2-dehydrogenase activity
TRAD_RS02400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TRAD_RS02425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TRAD_RS02430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TRAD_RS02435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TRAD_RS02445	COG0557	exoribonuclease II activity
TRAD_RS02455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TRAD_RS02485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TRAD_RS02500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TRAD_RS02525	COG1105	Belongs to the carbohydrate kinase PfkB family
TRAD_RS02540	COG0850	regulation of cytokinetic process
TRAD_RS02545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TRAD_RS02550	COG1132	(ABC) transporter
TRAD_RS02570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TRAD_RS02580	COG1408	metallophosphoesterase
TRAD_RS02590	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TRAD_RS02590	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TRAD_RS02620	COG1215	transferase activity, transferring glycosyl groups
TRAD_RS02665	COG1183	phosphatidylcholine synthase activity
TRAD_RS02670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TRAD_RS02675	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TRAD_RS02685	COG2217	Heavy metal translocating P-type atpase
TRAD_RS02705	COG0604	alcohol dehydrogenase
TRAD_RS02715	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TRAD_RS02760	COG1596	polysaccharide export
TRAD_RS02760	COG1555	photosystem II stabilization
TRAD_RS02765	COG2333	competence protein COMEC
TRAD_RS02765	COG0658	competence protein
TRAD_RS02785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TRAD_RS02790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TRAD_RS02805	COG0697	spore germination
TRAD_RS02810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TRAD_RS02815	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TRAD_RS02825	COG1272	protein, Hemolysin III
TRAD_RS02830	COG3361	conserved protein (COG2071)
TRAD_RS02840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TRAD_RS02855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TRAD_RS02860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TRAD_RS02885	COG0559	Belongs to the binding-protein-dependent transport system permease family
TRAD_RS02890	COG1022	Amp-dependent synthetase and ligase
TRAD_RS02905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TRAD_RS02910	COG1131	(ABC) transporter
TRAD_RS02920	COG2814	Major facilitator Superfamily
TRAD_RS02925	COG0746	molybdenum cofactor guanylyltransferase activity
TRAD_RS02930	COG0412	Dienelactone hydrolase
TRAD_RS02940	COG0513	Belongs to the DEAD box helicase family
TRAD_RS02950	COG0395	ABC-type sugar transport system, permease component
TRAD_RS02965	COG0515	serine threonine protein kinase
TRAD_RS02965	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TRAD_RS02975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TRAD_RS02980	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TRAD_RS02985	COG0740	serine-type endopeptidase activity
TRAD_RS03030	COG0714	Associated with various cellular activities
TRAD_RS03040	COG4603	Belongs to the binding-protein-dependent transport system permease family
TRAD_RS03045	COG1079	Belongs to the binding-protein-dependent transport system permease family
TRAD_RS03095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TRAD_RS03100	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS03115	COG1653	transport
TRAD_RS03120	COG2255	four-way junction helicase activity
TRAD_RS03125	COG0534	Mate efflux family protein
TRAD_RS03130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TRAD_RS03135	COG0788	formyltetrahydrofolate deformylase activity
TRAD_RS03140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TRAD_RS03145	COG0358	DNA primase activity
TRAD_RS03155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TRAD_RS03175	COG0297	glycogen (starch) synthase activity
TRAD_RS03200	COG1132	(ABC) transporter
TRAD_RS03210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TRAD_RS03215	COG0540	Belongs to the ATCase OTCase family
TRAD_RS03220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TRAD_RS03230	COG2816	NAD+ diphosphatase activity
TRAD_RS03235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TRAD_RS03245	COG3870	Protein conserved in bacteria
TRAD_RS03265	COG0616	signal peptide processing
TRAD_RS03280	COG0183	Belongs to the thiolase family
TRAD_RS03295	COG1904	glucuronate isomerase
TRAD_RS03300	COG3265	gluconokinase activity
TRAD_RS03315	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS03335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TRAD_RS03345	COG0673	inositol 2-dehydrogenase activity
TRAD_RS03355	COG0318	PFAM AMP-dependent synthetase and ligase
TRAD_RS03365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TRAD_RS03385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TRAD_RS03400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TRAD_RS03405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TRAD_RS03410	COG0006	proline dipeptidase activity
TRAD_RS03420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TRAD_RS03425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TRAD_RS03430	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TRAD_RS03445	COG5002	protein histidine kinase activity
TRAD_RS03460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TRAD_RS03465	COG2197	response regulator
TRAD_RS03470	COG0673	inositol 2-dehydrogenase activity
TRAD_RS03485	COG1172	Belongs to the binding-protein-dependent transport system permease family
TRAD_RS03505	COG0673	inositol 2-dehydrogenase activity
TRAD_RS03525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TRAD_RS03535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TRAD_RS03540	COG1983	PspC domain protein
TRAD_RS03560	COG2165	general secretion pathway protein
TRAD_RS03585	COG3250	beta-galactosidase activity
TRAD_RS03595	COG1175	transmembrane transport
TRAD_RS03600	COG0395	ABC-type sugar transport system, permease component
TRAD_RS03615	COG3685	Protein conserved in bacteria
TRAD_RS03625	COG3546	catalase activity
TRAD_RS03650	COG0529	Catalyzes the synthesis of activated sulfate
TRAD_RS03655	COG2046	Belongs to the sulfate adenylyltransferase family
TRAD_RS03660	COG1218	3'(2'),5'-bisphosphate nucleotidase
TRAD_RS03665	COG0438	transferase activity, transferring glycosyl groups
TRAD_RS03670	COG0438	transferase activity, transferring glycosyl groups
TRAD_RS03690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TRAD_RS03695	COG4978	Transcriptional regulator
TRAD_RS03695	COG0789	Transcriptional regulator
TRAD_RS03700	COG0372	Belongs to the citrate synthase family
TRAD_RS03705	COG3174	membrane
TRAD_RS03710	COG0514	ATP-dependent DNA helicase (RecQ)
TRAD_RS03720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TRAD_RS03725	COG0022	dehydrogenase e1 component
TRAD_RS03730	COG0508	dehydrogenase complex catalyzes the overall conversion of
TRAD_RS03755	COG1136	(ABC) transporter
TRAD_RS03755	COG0577	efflux transmembrane transporter activity
TRAD_RS03760	COG1994	Peptidase M50
TRAD_RS03770	COG3620	sequence-specific DNA binding
TRAD_RS03770	COG0617	tRNA 3'-terminal CCA addition
TRAD_RS03770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TRAD_RS03775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TRAD_RS03780	COG1363	Peptidase, m42
TRAD_RS03785	COG1247	-acetyltransferase
TRAD_RS03790	COG0492	ferredoxin-NADP+ reductase activity
TRAD_RS03795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TRAD_RS03805	COG1459	type II secretion system
TRAD_RS03830	COG1121	(ABC) transporter
TRAD_RS03835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TRAD_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS03845	COG1132	(ABC) transporter
TRAD_RS03850	COG1132	(ABC) transporter
TRAD_RS03875	COG0254	rRNA binding
TRAD_RS03880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TRAD_RS03885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TRAD_RS03895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TRAD_RS03900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TRAD_RS03905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TRAD_RS03940	COG0745	RESPONSE REGULATOR receiver
TRAD_RS03945	COG1957	nucleoside hydrolase
TRAD_RS03975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TRAD_RS03985	COG1937	Protein conserved in bacteria
TRAD_RS04025	COG0577	efflux transmembrane transporter activity
TRAD_RS04025	COG1136	(ABC) transporter
TRAD_RS04030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TRAD_RS04035	COG0742	ribosomal rna small subunit methyltransferase
TRAD_RS04040	COG0477	Major facilitator Superfamily
TRAD_RS04045	COG0653	protein targeting
TRAD_RS04050	COG0284	orotidine-5'-phosphate decarboxylase activity
TRAD_RS04065	COG1461	Dihydroxyacetone kinase
TRAD_RS04090	COG0101	tRNA pseudouridine synthase activity
TRAD_RS04120	COG0471	metal ion transport
TRAD_RS04130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TRAD_RS04135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TRAD_RS04170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TRAD_RS04180	COG1012	belongs to the aldehyde dehydrogenase family
TRAD_RS04205	COG1175	transmembrane transport
TRAD_RS04210	COG1653	transport
TRAD_RS04215	COG1231	oxidoreductase activity
TRAD_RS04220	COG1960	acyl-CoA dehydrogenase activity
TRAD_RS04235	COG1285	pathogenesis
TRAD_RS04240	COG2239	Acts as a magnesium transporter
TRAD_RS04245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TRAD_RS04260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TRAD_RS04270	COG1121	(ABC) transporter
TRAD_RS04295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TRAD_RS04300	COG0424	maF-like protein
TRAD_RS04305	COG0268	Binds directly to 16S ribosomal RNA
TRAD_RS04315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TRAD_RS04320	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TRAD_RS04340	COG1876	peptidase activity
TRAD_RS04350	COG1858	cytochrome C peroxidase
TRAD_RS04405	COG0704	Plays a role in the regulation of phosphate uptake
TRAD_RS04415	COG0745	RESPONSE REGULATOR receiver
TRAD_RS04440	COG2860	membrane
TRAD_RS04475	COG0673	inositol 2-dehydrogenase activity
TRAD_RS04495	COG0567	Dehydrogenase, E1 component
TRAD_RS04500	COG0508	dehydrogenase complex catalyzes the overall conversion of
TRAD_RS04505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TRAD_RS04510	COG0671	phosphoesterase, PA-phosphatase related
TRAD_RS04520	COG1648	precorrin-2 dehydrogenase activity
TRAD_RS04520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TRAD_RS04525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TRAD_RS04530	COG0175	sulfate reduction
TRAD_RS04535	COG2133	pyrroloquinoline quinone binding
TRAD_RS04540	COG4284	Utp--glucose-1-phosphate uridylyltransferase
TRAD_RS04545	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TRAD_RS04550	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TRAD_RS04560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TRAD_RS04565	COG2986	histidine ammonia-lyase
TRAD_RS04570	COG3314	Sporulation integral membrane protein YlbJ
TRAD_RS04575	COG1228	amidohydrolase
TRAD_RS04580	COG0010	Belongs to the arginase family
TRAD_RS04585	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TRAD_RS04595	COG0493	'glutamate synthase
TRAD_RS04620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TRAD_RS04625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TRAD_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS04635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TRAD_RS04705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS04710	COG0601	transmembrane transport
TRAD_RS04720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TRAD_RS04725	COG1473	amidohydrolase
TRAD_RS04730	COG1609	Transcriptional regulator
TRAD_RS04735	COG1653	transport
TRAD_RS04740	COG1175	transmembrane transport
TRAD_RS04745	COG0395	ABC-type sugar transport system, permease component
TRAD_RS04750	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
TRAD_RS04755	COG0438	transferase activity, transferring glycosyl groups
TRAD_RS04765	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TRAD_RS04805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TRAD_RS04830	COG1917	Cupin 2, conserved barrel domain protein
TRAD_RS04830	COG2207	Transcriptional regulator
TRAD_RS04840	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TRAD_RS04845	COG0174	glutamine synthetase
TRAD_RS04875	COG0300	oxidoreductase activity
TRAD_RS04880	COG0527	aspartate kinase activity
TRAD_RS04885	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TRAD_RS04905	COG0163	prenyltransferase activity
TRAD_RS04910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TRAD_RS04915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TRAD_RS04930	COG0129	dihydroxy-acid dehydratase activity
TRAD_RS04935	COG1085	galactose-1-phosphate uridylyltransferase
TRAD_RS04945	COG1349	DNA-binding transcription factor activity
TRAD_RS04955	COG1129	ABC transporter
TRAD_RS04960	COG1172	Belongs to the binding-protein-dependent transport system permease family
TRAD_RS04965	COG1070	Carbohydrate kinase
TRAD_RS04975	COG1070	Carbohydrate kinase
TRAD_RS04985	COG2337	Toxic component of a toxin-antitoxin (TA) module
TRAD_RS04995	COG1254	Belongs to the acylphosphatase family
TRAD_RS05000	COG0134	indole-3-glycerol-phosphate synthase activity
TRAD_RS05005	COG4221	oxidoreductase activity
TRAD_RS05010	COG0612	Peptidase, M16
TRAD_RS05015	COG0612	Peptidase, M16
TRAD_RS05045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TRAD_RS05050	COG1136	(ABC) transporter
TRAD_RS05050	COG0577	efflux transmembrane transporter activity
TRAD_RS05055	COG1131	(ABC) transporter
TRAD_RS05070	COG0003	Pfam Anion-transporting ATPase
TRAD_RS05080	COG1966	Carbon starvation protein
TRAD_RS05120	COG0437	4 iron, 4 sulfur cluster binding
TRAD_RS05130	COG0009	L-threonylcarbamoyladenylate synthase
TRAD_RS05140	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TRAD_RS05155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TRAD_RS05160	COG0049	tRNA binding
TRAD_RS05170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TRAD_RS05175	COG0051	transcription antitermination factor activity, RNA binding
TRAD_RS05180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TRAD_RS05185	COG0088	Forms part of the polypeptide exit tunnel
TRAD_RS05190	COG0089	rRNA binding
TRAD_RS05195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TRAD_RS05200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TRAD_RS05210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TRAD_RS05215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TRAD_RS05220	COG0255	Belongs to the universal ribosomal protein uL29 family
TRAD_RS05225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TRAD_RS05230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TRAD_RS05245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TRAD_RS05255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TRAD_RS05265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TRAD_RS05270	COG1841	ribosomal large subunit assembly
TRAD_RS05275	COG0200	Binds to the 23S rRNA
TRAD_RS05280	COG0201	protein transport
TRAD_RS05285	COG0563	adenylate kinase activity
TRAD_RS05290	COG0024	Methionine aminopeptidase
TRAD_RS05295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TRAD_RS05300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TRAD_RS05305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TRAD_RS05310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TRAD_RS05315	COG0202	RNA polymerase activity
TRAD_RS05320	COG0203	ribosomal protein L17
TRAD_RS05330	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TRAD_RS05335	COG1136	(ABC) transporter
TRAD_RS05340	COG0577	efflux transmembrane transporter activity
TRAD_RS05340	COG1136	(ABC) transporter
TRAD_RS05360	COG2197	response regulator
TRAD_RS05370	COG0316	Belongs to the HesB IscA family
TRAD_RS05375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TRAD_RS05380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TRAD_RS05385	COG0509	glycine decarboxylation via glycine cleavage system
TRAD_RS05390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TRAD_RS05395	COG1100	Small GTP-binding protein
TRAD_RS05405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TRAD_RS05415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TRAD_RS05420	COG0825	malonyl-CoA metabolic process
TRAD_RS05425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TRAD_RS05435	COG2897	thiosulfate sulfurtransferase activity
TRAD_RS05445	COG1959	2 iron, 2 sulfur cluster binding
TRAD_RS05450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TRAD_RS05460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TRAD_RS05465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TRAD_RS05490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TRAD_RS05490	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TRAD_RS05495	COG0420	3'-5' exonuclease activity
TRAD_RS05500	COG0419	ATPase involved in DNA repair
TRAD_RS05515	COG0492	ferredoxin-NADP+ reductase activity
TRAD_RS05540	COG0142	geranyltranstransferase activity
TRAD_RS05550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TRAD_RS05555	COG0511	ligase activity, forming carbon-carbon bonds
TRAD_RS05560	COG0439	Biotin carboxylase
TRAD_RS05565	COG1302	Protein conserved in bacteria
TRAD_RS05570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TRAD_RS05575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TRAD_RS05585	COG2309	aminopeptidase activity
TRAD_RS05600	COG0667	Aldo Keto reductase
TRAD_RS05610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS05615	COG0601	transmembrane transport
TRAD_RS05635	COG1846	Transcriptional regulator
TRAD_RS05640	COG2259	Doxx family
TRAD_RS05645	COG2514	catechol 2,3-dioxygenase activity
TRAD_RS05650	COG0123	including yeast histone deacetylase and acetoin utilization protein
TRAD_RS05675	COG1172	Belongs to the binding-protein-dependent transport system permease family
TRAD_RS05680	COG1172	Belongs to the binding-protein-dependent transport system permease family
TRAD_RS05685	COG1129	ABC transporter
TRAD_RS05695	COG3396	Phenylacetate-CoA oxygenase
TRAD_RS05710	COG2151	metal-sulfur cluster biosynthetic enzyme
TRAD_RS05720	COG0628	permease
TRAD_RS05725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TRAD_RS05730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TRAD_RS05735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TRAD_RS05750	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TRAD_RS05755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TRAD_RS05760	COG4558	Periplasmic binding protein
TRAD_RS05775	COG0778	Nitroreductase
TRAD_RS05780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TRAD_RS05790	COG0154	amidase activity
TRAD_RS05805	COG1136	(ABC) transporter
TRAD_RS05880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TRAD_RS05910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TRAD_RS05915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TRAD_RS05955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TRAD_RS05970	COG0395	ABC-type sugar transport system, permease component
TRAD_RS05975	COG1175	transmembrane transport
TRAD_RS05980	COG2182	Extracellular solute-binding protein
TRAD_RS05995	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TRAD_RS06005	COG2226	methyltransferase
TRAD_RS06015	COG0445	tRNA wobble uridine modification
TRAD_RS06040	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TRAD_RS06045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TRAD_RS06055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TRAD_RS06070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TRAD_RS06080	COG0371	Dehydrogenase
TRAD_RS06090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TRAD_RS06095	COG1234	tRNA 3'-trailer cleavage
TRAD_RS06100	COG1012	belongs to the aldehyde dehydrogenase family
TRAD_RS06105	COG3718	enzyme involved in inositol metabolism
TRAD_RS06110	COG1082	Xylose isomerase domain protein TIM barrel
TRAD_RS06115	COG0673	inositol 2-dehydrogenase activity
TRAD_RS06120	COG3962	Belongs to the TPP enzyme family
TRAD_RS06125	COG0673	inositol 2-dehydrogenase activity
TRAD_RS06135	COG4214	carbohydrate transport
TRAD_RS06145	COG1349	DNA-binding transcription factor activity
TRAD_RS06170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TRAD_RS06175	COG0446	pyridine nucleotide-disulphide oxidoreductase
TRAD_RS06200	COG4214	carbohydrate transport
TRAD_RS06205	COG4213	ABC transporter substrate-binding protein
TRAD_RS06255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TRAD_RS06260	COG0045	succinate-CoA ligase (ADP-forming) activity
TRAD_RS06265	COG3119	arylsulfatase activity
TRAD_RS06275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TRAD_RS06280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TRAD_RS06285	COG3119	arylsulfatase activity
TRAD_RS06290	COG0505	Belongs to the CarA family
TRAD_RS06295	COG0628	permease
TRAD_RS06310	COG0628	permease
TRAD_RS06315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TRAD_RS06330	COG1490	D-aminoacyl-tRNA deacylase activity
TRAD_RS06340	COG1573	uracil-dna glycosylase
TRAD_RS06375	COG0552	protein localization to endoplasmic reticulum
TRAD_RS06380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TRAD_RS06385	COG1968	undecaprenyl-diphosphatase activity
TRAD_RS06390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TRAD_RS06395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TRAD_RS06410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TRAD_RS06415	COG1136	(ABC) transporter
TRAD_RS06420	COG0747	negative chemotaxis
TRAD_RS06425	COG0601	transmembrane transport
TRAD_RS06430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS06435	COG0277	FAD linked oxidase domain protein
TRAD_RS06440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TRAD_RS06455	COG0488	(ABC) transporter
TRAD_RS06500	COG0481	GTPase activity
TRAD_RS06525	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TRAD_RS06535	COG1396	sequence-specific DNA binding
TRAD_RS06540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS06545	COG0601	transmembrane transport
TRAD_RS06550	COG0747	negative chemotaxis
TRAD_RS06555	COG0006	proline dipeptidase activity
TRAD_RS06570	COG0667	Aldo Keto reductase
TRAD_RS06575	COG1131	(ABC) transporter
TRAD_RS06590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TRAD_RS06595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TRAD_RS06600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TRAD_RS06605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TRAD_RS06610	COG1450	Type ii and iii secretion system protein
TRAD_RS06645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TRAD_RS06650	COG0305	Participates in initiation and elongation during chromosome replication
TRAD_RS06660	COG2264	protein methyltransferase activity
TRAD_RS06675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TRAD_RS06675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TRAD_RS06685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TRAD_RS06695	COG0195	Participates in both transcription termination and antitermination
TRAD_RS06700	COG0779	Required for maturation of 30S ribosomal subunits
TRAD_RS06705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TRAD_RS06720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TRAD_RS06730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TRAD_RS06735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TRAD_RS06755	COG0793	Belongs to the peptidase S41A family
TRAD_RS06760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TRAD_RS06775	COG1940	carbohydrate kinase activity
TRAD_RS06800	COG1024	Enoyl-CoA hydratase
TRAD_RS06810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TRAD_RS06820	COG0187	DNA topoisomerase II activity
TRAD_RS06825	COG1515	deoxyribonuclease V activity
TRAD_RS06835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TRAD_RS06840	COG0217	transcriptional regulatory protein
TRAD_RS06855	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TRAD_RS06860	COG0517	IMP dehydrogenase activity
TRAD_RS06860	COG0516	GMP reductase activity
TRAD_RS06870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TRAD_RS06895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TRAD_RS06900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TRAD_RS06905	COG0066	3-isopropylmalate dehydratase activity
TRAD_RS06910	COG0189	ligase activity
TRAD_RS06925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TRAD_RS06930	COG0402	S-adenosylhomocysteine deaminase activity
TRAD_RS06945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TRAD_RS06950	COG0494	nUDIX hydrolase
TRAD_RS06955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TRAD_RS06960	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
TRAD_RS06970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TRAD_RS06975	COG1597	lipid kinase activity
TRAD_RS06980	COG1024	Enoyl-CoA hydratase
TRAD_RS06980	COG1250	3-hydroxyacyl-CoA dehydrogenase
TRAD_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS06990	COG0484	heat shock protein binding
TRAD_RS06995	COG0789	Transcriptional regulator
TRAD_RS07020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TRAD_RS07030	COG3842	ATPase activity
TRAD_RS07050	COG0366	Alpha amylase catalytic
TRAD_RS07110	COG1187	pseudouridine synthase activity
TRAD_RS07115	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TRAD_RS07140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TRAD_RS07140	COG5297	Belongs to the glycosyl hydrolase family 6
TRAD_RS07145	COG0366	Alpha amylase catalytic
TRAD_RS07155	COG1175	transmembrane transport
TRAD_RS07160	COG0395	ABC-type sugar transport system, permease component
TRAD_RS07200	COG0180	Tryptophanyl-tRNA synthetase
TRAD_RS07215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TRAD_RS07225	COG4943	cyclic-guanylate-specific phosphodiesterase activity
TRAD_RS07230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TRAD_RS07245	COG0285	dihydrofolate synthase activity
TRAD_RS07250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TRAD_RS07260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TRAD_RS07275	COG3206	protein involved in exopolysaccharide biosynthesis
TRAD_RS07285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TRAD_RS07290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TRAD_RS07305	COG1940	carbohydrate kinase activity
TRAD_RS07320	COG0154	amidase activity
TRAD_RS07345	COG0647	UMP catabolic process
TRAD_RS07360	COG4214	carbohydrate transport
TRAD_RS07365	COG1609	Transcriptional regulator
TRAD_RS07375	COG2160	L-arabinose isomerase activity
TRAD_RS07390	COG2197	response regulator
TRAD_RS07415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TRAD_RS07425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TRAD_RS07430	COG1620	l-lactate permease
TRAD_RS07435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TRAD_RS07450	COG3195	allantoin biosynthetic process
TRAD_RS07450	COG3648	Uricase
TRAD_RS07455	COG2351	hydroxyisourate hydrolase activity
TRAD_RS07460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TRAD_RS07465	COG3257	ureidoglycine aminohydrolase activity
TRAD_RS07490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TRAD_RS07500	COG2226	methyltransferase
TRAD_RS07510	COG2815	serine threonine protein kinase
TRAD_RS07510	COG0515	serine threonine protein kinase
TRAD_RS07565	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TRAD_RS07570	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TRAD_RS07585	COG1175	transmembrane transport
TRAD_RS07590	COG0395	ABC-type sugar transport system, permease component
TRAD_RS07595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TRAD_RS07615	COG1012	belongs to the aldehyde dehydrogenase family
TRAD_RS07625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TRAD_RS07630	COG2224	Isocitrate lyase
TRAD_RS07645	COG2197	response regulator
TRAD_RS07655	COG1196	nuclear chromosome segregation
TRAD_RS07690	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TRAD_RS07695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TRAD_RS07700	COG0047	phosphoribosylformylglycinamidine synthase activity
TRAD_RS07705	COG0156	8-amino-7-oxononanoate synthase activity
TRAD_RS07720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TRAD_RS07725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TRAD_RS07750	COG0577	efflux transmembrane transporter activity
TRAD_RS07755	COG0577	efflux transmembrane transporter activity
TRAD_RS07755	COG1136	(ABC) transporter
TRAD_RS07760	COG2409	Drug exporters of the RND superfamily
TRAD_RS07765	COG0277	FAD linked oxidase domain protein
TRAD_RS07770	COG0277	FAD linked oxidase domain protein
TRAD_RS07775	COG0247	lactate metabolic process
TRAD_RS07780	COG1174	glycine betaine transport
TRAD_RS07785	COG0517	IMP dehydrogenase activity
TRAD_RS07785	COG1125	glycine betaine transport
TRAD_RS07790	COG1174	glycine betaine transport
TRAD_RS07795	COG1732	Glycine betaine
TRAD_RS07805	COG1181	Belongs to the D-alanine--D-alanine ligase family
TRAD_RS07820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TRAD_RS07825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TRAD_RS07840	COG0640	Transcriptional regulator
TRAD_RS07855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TRAD_RS07860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TRAD_RS07865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TRAD_RS07880	COG1854	S-ribosylhomocysteine lyase activity
TRAD_RS07905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TRAD_RS07910	COG1744	ABC transporter substrate-binding protein PnrA-like
TRAD_RS07915	COG2001	Belongs to the MraZ family
TRAD_RS07920	COG0275	rRNA processing
TRAD_RS07935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TRAD_RS07940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TRAD_RS07945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TRAD_RS07950	COG0772	Belongs to the SEDS family
TRAD_RS07955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TRAD_RS07960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TRAD_RS07965	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TRAD_RS07970	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TRAD_RS07980	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TRAD_RS07985	COG0494	nUDIX hydrolase
TRAD_RS07990	COG0196	riboflavin kinase activity
TRAD_RS07995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TRAD_RS08000	COG1506	peptidase
TRAD_RS08000	COG4946	Tricorn protease homolog
TRAD_RS08000	COG0823	Involved in the tonB-independent uptake of proteins
TRAD_RS08020	COG1072	(Pantothenic acid kinase))
TRAD_RS08030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TRAD_RS08035	COG1185	polyribonucleotide nucleotidyltransferase activity
TRAD_RS08040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TRAD_RS08050	COG0667	Aldo Keto reductase
TRAD_RS08055	COG0667	Aldo Keto reductase
TRAD_RS08060	COG0656	L-ascorbic acid biosynthetic process
TRAD_RS08075	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TRAD_RS08095	COG0473	3-isopropylmalate dehydrogenase activity
TRAD_RS08110	COG2321	neutral zinc metallopeptidase
TRAD_RS08115	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TRAD_RS08120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TRAD_RS08165	COG0215	cysteine-tRNA ligase activity
TRAD_RS08170	COG0758	DNA mediated transformation
TRAD_RS08175	COG0366	Alpha amylase catalytic
TRAD_RS08180	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TRAD_RS08195	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TRAD_RS08290	COG1518	maintenance of DNA repeat elements
TRAD_RS08295	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TRAD_RS08305	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS08325	COG1320	monovalent cation:proton antiporter activity
TRAD_RS08335	COG2111	Na H antiporter
TRAD_RS08335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TRAD_RS08340	COG1006	Multisubunit Na H antiporter MnhC subunit
TRAD_RS08345	COG1007	ATP synthesis coupled electron transport
TRAD_RS08370	COG0813	purine-nucleoside phosphorylase activity
TRAD_RS08375	COG1250	3-hydroxyacyl-CoA dehydrogenase
TRAD_RS08380	COG1024	Enoyl-CoA hydratase
TRAD_RS08395	COG2267	carboxylic ester hydrolase activity
TRAD_RS08400	COG3845	ABC transporter
TRAD_RS08405	COG4603	Belongs to the binding-protein-dependent transport system permease family
TRAD_RS08410	COG1079	Belongs to the binding-protein-dependent transport system permease family
TRAD_RS08420	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TRAD_RS08425	COG1160	GTP binding
TRAD_RS08430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TRAD_RS08445	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TRAD_RS08450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TRAD_RS08470	COG0354	folic acid binding
TRAD_RS08475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TRAD_RS08475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TRAD_RS08480	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TRAD_RS08490	COG1070	Carbohydrate kinase
TRAD_RS08495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TRAD_RS08505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TRAD_RS08515	COG0747	negative chemotaxis
TRAD_RS08520	COG0601	transmembrane transport
TRAD_RS08525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS08530	COG0402	S-adenosylhomocysteine deaminase activity
TRAD_RS08540	COG1960	acyl-CoA dehydrogenase activity
TRAD_RS08570	COG1653	transport
TRAD_RS08580	COG0395	ABC-type sugar transport system, permease component
TRAD_RS08585	COG0179	Fumarylacetoacetate (FAA) hydrolase
TRAD_RS08595	COG1175	transmembrane transport
TRAD_RS08600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TRAD_RS08610	COG4175	Glycine betaine
TRAD_RS08610	COG3448	diguanylate cyclase activity
TRAD_RS08615	COG4176	ABC-type proline glycine betaine transport system permease component
TRAD_RS08650	COG0651	ATP synthesis coupled electron transport
TRAD_RS08670	COG1320	monovalent cation:proton antiporter activity
TRAD_RS08685	COG0137	argininosuccinate synthase activity
TRAD_RS08705	COG0165	Argininosuccinate lyase
TRAD_RS08710	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TRAD_RS08725	COG0252	asparaginase activity
TRAD_RS08750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TRAD_RS08760	COG0343	queuine tRNA-ribosyltransferase activity
TRAD_RS08765	COG1484	DNA-dependent DNA replication
TRAD_RS08770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TRAD_RS08780	COG0124	histidyl-tRNA synthetase
TRAD_RS08795	COG0017	Asparaginyl-tRNA synthetase
TRAD_RS08810	COG0488	(ABC) transporter
TRAD_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS08875	COG0517	IMP dehydrogenase activity
TRAD_RS08905	COG0574	Belongs to the PEP-utilizing enzyme family
TRAD_RS08905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TRAD_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS08915	COG1653	transport
TRAD_RS08920	COG1104	cysteine desulfurase activity
TRAD_RS08925	COG1959	2 iron, 2 sulfur cluster binding
TRAD_RS08960	COG4974	Belongs to the 'phage' integrase family
TRAD_RS08990	COG0470	DNA polymerase III
TRAD_RS09045	COG1609	Transcriptional regulator
TRAD_RS09050	COG0395	ABC-type sugar transport system, permease component
TRAD_RS09055	COG1175	transmembrane transport
TRAD_RS09065	COG2081	HI0933 family
TRAD_RS09070	COG0667	Aldo Keto reductase
TRAD_RS09090	COG0673	inositol 2-dehydrogenase activity
TRAD_RS09100	COG0747	negative chemotaxis
TRAD_RS09115	COG0673	inositol 2-dehydrogenase activity
TRAD_RS09120	COG0673	inositol 2-dehydrogenase activity
TRAD_RS09125	COG0673	inositol 2-dehydrogenase activity
TRAD_RS09140	COG0673	inositol 2-dehydrogenase activity
TRAD_RS09155	COG4608	Belongs to the ABC transporter superfamily
TRAD_RS09165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS09175	COG2813	Specifically methylates the guanine in position
TRAD_RS09180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TRAD_RS09185	COG0438	transferase activity, transferring glycosyl groups
TRAD_RS09240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TRAD_RS09245	COG1573	uracil-dna glycosylase
TRAD_RS09250	COG1045	serine acetyltransferase
TRAD_RS09255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TRAD_RS09260	COG2267	carboxylic ester hydrolase activity
TRAD_RS09270	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS09275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TRAD_RS09300	COG2226	methyltransferase
TRAD_RS09305	COG2261	transglycosylase associated protein
TRAD_RS09315	COG0506	proline dehydrogenase activity
TRAD_RS09320	COG1012	belongs to the aldehyde dehydrogenase family
TRAD_RS09355	COG2368	4-hydroxyphenylacetate
TRAD_RS09365	COG1012	belongs to the aldehyde dehydrogenase family
TRAD_RS09380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TRAD_RS09385	COG2050	protein possibly involved in aromatic compounds catabolism
TRAD_RS09390	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TRAD_RS09400	COG1012	belongs to the aldehyde dehydrogenase family
TRAD_RS09400	COG2030	dehydratase
TRAD_RS09415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TRAD_RS09420	COG0581	inorganic phosphate transmembrane transporter activity
TRAD_RS09425	COG0573	inorganic phosphate transmembrane transporter activity
TRAD_RS09430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TRAD_RS09445	COG3639	organic phosphonate transmembrane transporter activity
TRAD_RS09450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TRAD_RS09465	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TRAD_RS09470	COG3639	organic phosphonate transmembrane transporter activity
TRAD_RS09490	COG1733	regulation of RNA biosynthetic process
TRAD_RS09505	COG0534	Mate efflux family protein
TRAD_RS09515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TRAD_RS09520	COG0561	phosphatase activity
TRAD_RS09525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TRAD_RS09530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TRAD_RS09535	COG4591	ABC-type transport system involved in lipoprotein release permease component
TRAD_RS09560	COG2050	protein possibly involved in aromatic compounds catabolism
TRAD_RS09565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TRAD_RS09580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TRAD_RS09585	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TRAD_RS09595	COG0805	protein transport
TRAD_RS09600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TRAD_RS09600	COG1605	Chorismate mutase
TRAD_RS09630	COG0673	inositol 2-dehydrogenase activity
TRAD_RS09635	COG1111	helicase
TRAD_RS09635	COG1205	dead DEAH box helicase
TRAD_RS09665	COG0628	permease
TRAD_RS09670	COG0504	CTP synthase activity
TRAD_RS09695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TRAD_RS09700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TRAD_RS09705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TRAD_RS09715	COG0667	Aldo Keto reductase
TRAD_RS09720	COG0205	6-phosphofructokinase activity
TRAD_RS09745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TRAD_RS09750	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TRAD_RS09755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TRAD_RS09765	COG0586	Pfam SNARE associated Golgi protein
TRAD_RS09775	COG0322	excinuclease ABC activity
TRAD_RS09790	COG0395	ABC-type sugar transport system, permease component
TRAD_RS09800	COG1486	melibiose metabolic process
TRAD_RS09810	COG0339	signal peptide processing
TRAD_RS09825	COG0183	Belongs to the thiolase family
TRAD_RS09830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TRAD_RS09835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TRAD_RS09840	COG2313	pseudouridylate synthase activity
TRAD_RS09860	COG0577	efflux transmembrane transporter activity
TRAD_RS09860	COG1136	(ABC) transporter
TRAD_RS09865	COG2363	Small membrane protein
TRAD_RS09870	COG3685	Protein conserved in bacteria
TRAD_RS09880	COG1305	Transglutaminase-like
TRAD_RS09895	COG2308	Evidence 4 Homologs of previously reported genes of
TRAD_RS09900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TRAD_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS09925	COG0514	ATP-dependent DNA helicase (RecQ)
TRAD_RS09945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TRAD_RS09950	COG3132	Protein of unknown function, DUF480
TRAD_RS09960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TRAD_RS09965	COG1126	abc transporter atp-binding protein
TRAD_RS09970	COG0765	amino acid transport
TRAD_RS09985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TRAD_RS09990	COG1394	ATPase activity, coupled to movement of substances
TRAD_RS09995	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TRAD_RS10000	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TRAD_RS10010	COG1527	subunit (C
TRAD_RS10025	COG1269	ATP hydrolysis coupled proton transport
TRAD_RS10035	COG0515	serine threonine protein kinase
TRAD_RS10035	COG2815	serine threonine protein kinase
TRAD_RS10055	COG0494	nUDIX hydrolase
TRAD_RS10060	COG3956	TIGRFAM MazG family protein
TRAD_RS10065	COG1496	oxidoreductase activity
TRAD_RS10075	COG2827	Endonuclease containing a URI domain
TRAD_RS10085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TRAD_RS10090	COG1609	Transcriptional regulator
TRAD_RS10095	COG1874	Beta-galactosidase
TRAD_RS10110	COG1175	transmembrane transport
TRAD_RS10115	COG0395	ABC-type sugar transport system, permease component
TRAD_RS10170	COG0416	fatty acid biosynthetic process
TRAD_RS10175	COG0564	pseudouridine synthase activity
TRAD_RS10185	COG0438	transferase activity, transferring glycosyl groups
TRAD_RS10215	COG1846	Transcriptional regulator
TRAD_RS10240	COG2205	protein histidine kinase activity
TRAD_RS10250	COG2045	Belongs to the ComB family
TRAD_RS10260	COG0393	Putative heavy-metal-binding
TRAD_RS10265	COG0017	Asparaginyl-tRNA synthetase
TRAD_RS10270	COG1435	thymidine kinase activity
TRAD_RS10280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TRAD_RS10285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TRAD_RS10290	COG1217	gtp-binding protein TYPA
TRAD_RS10305	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TRAD_RS10340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TRAD_RS10345	COG0321	lipoyl(octanoyl) transferase activity
TRAD_RS10355	COG1278	Cold shock
TRAD_RS10365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TRAD_RS10400	COG3507	Belongs to the glycosyl hydrolase 43 family
TRAD_RS10405	COG3693	PFAM glycoside hydrolase, family 10
TRAD_RS10420	COG0395	ABC-type sugar transport system, permease component
TRAD_RS10425	COG1175	transmembrane transport
TRAD_RS10435	COG3693	PFAM glycoside hydrolase, family 10
TRAD_RS10445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TRAD_RS10450	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TRAD_RS10455	COG3191	aminopeptidase activity
TRAD_RS10460	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TRAD_RS10475	COG0582	viral genome integration into host DNA
TRAD_RS10490	COG4154	Belongs to the RbsD FucU family
TRAD_RS10505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TRAD_RS10515	COG0604	alcohol dehydrogenase
TRAD_RS10515	COG3321	synthase
TRAD_RS10515	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS10520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TRAD_RS10525	COG4762	Protein conserved in bacteria
TRAD_RS10535	COG0495	leucyl-tRNA aminoacylation
TRAD_RS10560	COG1278	Cold shock
TRAD_RS10565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TRAD_RS10580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TRAD_RS10585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TRAD_RS10610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TRAD_RS10625	COG1902	pentaerythritol trinitrate reductase activity
TRAD_RS10630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TRAD_RS10640	COG3254	rhamnose metabolic process
TRAD_RS10670	COG1546	Belongs to the CinA family
TRAD_RS10670	COG1058	Belongs to the CinA family
TRAD_RS10675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TRAD_RS10680	COG1418	mRNA catabolic process
TRAD_RS10680	COG2433	Pfam Transposase IS66
TRAD_RS10685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TRAD_RS10690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TRAD_RS10695	COG0193	aminoacyl-tRNA hydrolase activity
TRAD_RS10700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TRAD_RS10705	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TRAD_RS10710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TRAD_RS10735	COG0596	Alpha beta hydrolase
TRAD_RS10755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TRAD_RS10770	COG1304	FMN binding
TRAD_RS10795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TRAD_RS10795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TRAD_RS10835	COG1063	alcohol dehydrogenase
TRAD_RS10840	COG2182	Extracellular solute-binding protein
TRAD_RS10845	COG1175	transmembrane transport
TRAD_RS10850	COG0395	ABC-type sugar transport system, permease component
TRAD_RS10855	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS10860	COG1063	alcohol dehydrogenase
TRAD_RS10870	COG0508	dehydrogenase complex catalyzes the overall conversion of
TRAD_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS10895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TRAD_RS10900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TRAD_RS10915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TRAD_RS10950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TRAD_RS10955	COG0066	3-isopropylmalate dehydratase activity
TRAD_RS10975	COG0521	Mo-molybdopterin cofactor biosynthetic process
TRAD_RS10990	COG4948	Mandelate Racemase Muconate Lactonizing
TRAD_RS10995	COG0751	glycine-tRNA ligase activity
TRAD_RS11000	COG0752	glycyl-tRNA synthetase alpha subunit
TRAD_RS11005	COG0542	response to heat
TRAD_RS11010	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TRAD_RS11015	COG4956	integral membrane protein (PIN domain superfamily)
TRAD_RS11040	COG0166	Belongs to the GPI family
TRAD_RS11045	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TRAD_RS11065	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TRAD_RS11065	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TRAD_RS11090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TRAD_RS11100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TRAD_RS11120	COG2311	Membrane
TRAD_RS11130	COG2311	Membrane
TRAD_RS11150	COG1215	transferase activity, transferring glycosyl groups
TRAD_RS11170	COG0393	Putative heavy-metal-binding
TRAD_RS11180	COG1562	ergosterol biosynthetic process
TRAD_RS11185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TRAD_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS11195	COG0693	protein deglycase activity
TRAD_RS11210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TRAD_RS11215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TRAD_RS11220	COG1116	anion transmembrane transporter activity
TRAD_RS11220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TRAD_RS11240	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TRAD_RS11245	COG0489	protein tyrosine kinase activity
TRAD_RS11255	COG0519	Catalyzes the synthesis of GMP from XMP
TRAD_RS11255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TRAD_RS11270	COG1473	amidohydrolase
TRAD_RS11275	COG1420	regulation of RNA biosynthetic process
TRAD_RS11280	COG0314	molybdopterin synthase activity
TRAD_RS11290	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS11300	COG0415	Belongs to the DNA photolyase family
TRAD_RS11305	COG3845	ABC transporter
TRAD_RS11310	COG3387	PFAM Glycoside hydrolase 15-related
TRAD_RS11315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TRAD_RS11325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TRAD_RS11330	COG2873	o-acetylhomoserine
TRAD_RS11335	COG2873	o-acetylhomoserine
TRAD_RS11340	COG1175	transmembrane transport
TRAD_RS11380	COG0747	negative chemotaxis
TRAD_RS11385	COG0601	transmembrane transport
TRAD_RS11390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS11395	COG0444	Belongs to the ABC transporter superfamily
TRAD_RS11410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TRAD_RS11415	COG1172	Belongs to the binding-protein-dependent transport system permease family
TRAD_RS11420	COG1129	ABC transporter
TRAD_RS11430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TRAD_RS11435	COG1653	transport
TRAD_RS11440	COG0395	ABC-type sugar transport system, permease component
TRAD_RS11445	COG4209	transmembrane transport
TRAD_RS11460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TRAD_RS11480	COG1857	crispr-associated protein
TRAD_RS11515	COG0739	heme binding
TRAD_RS11520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TRAD_RS11525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TRAD_RS11530	COG1295	ribonuclease BN
TRAD_RS11540	COG0126	phosphoglycerate kinase activity
TRAD_RS11555	COG1960	acyl-CoA dehydrogenase activity
TRAD_RS11565	COG1960	acyl-CoA dehydrogenase activity
TRAD_RS11590	COG0133	tryptophan synthase activity
TRAD_RS11595	COG0159	tryptophan synthase activity
TRAD_RS11600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TRAD_RS11610	COG0084	hydrolase, TatD family'
TRAD_RS11635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TRAD_RS11655	COG1304	FMN binding
TRAD_RS11660	COG4555	ABC transporter
TRAD_RS11665	COG1668	transmembrane transport
TRAD_RS11670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TRAD_RS11690	COG1132	(ABC) transporter
TRAD_RS11695	COG1132	(ABC) transporter
TRAD_RS11700	COG3842	ATPase activity
TRAD_RS11725	COG0484	heat shock protein binding
TRAD_RS11735	COG0683	leucine binding
TRAD_RS11750	COG1022	Amp-dependent synthetase and ligase
TRAD_RS11780	COG3844	kynureninase activity
TRAD_RS11785	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TRAD_RS11790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TRAD_RS11795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TRAD_RS11795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TRAD_RS11800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TRAD_RS11800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TRAD_RS11805	COG0083	homoserine kinase activity
TRAD_RS11820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TRAD_RS11830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TRAD_RS11835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TRAD_RS11840	COG1754	DNA topoisomerase type I activity
TRAD_RS11840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TRAD_RS11850	COG2884	Cell division ATP-binding protein ftsE
TRAD_RS11855	COG1404	Belongs to the peptidase S8 family
TRAD_RS11865	COG0848	biopolymer transport protein
TRAD_RS11870	COG0811	peptide transport
TRAD_RS11875	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TRAD_RS11880	COG1692	metallophosphoesterase
TRAD_RS11895	COG1522	sequence-specific DNA binding
TRAD_RS11920	COG2094	Belongs to the DNA glycosylase MPG family
TRAD_RS11930	COG0655	NAD(P)H dehydrogenase (quinone) activity
TRAD_RS11940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TRAD_RS11950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TRAD_RS11965	COG1597	lipid kinase activity
TRAD_RS11980	COG0004	ammonium transporteR
TRAD_RS11990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TRAD_RS12000	COG0243	molybdopterin cofactor binding
TRAD_RS12015	COG0667	Aldo Keto reductase
TRAD_RS12035	COG0601	transmembrane transport
TRAD_RS12040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS12045	COG2059	Chromate
TRAD_RS12055	COG0531	amino acid
TRAD_RS12060	COG1047	Peptidyl-prolyl cis-trans
TRAD_RS12090	COG0644	oxidoreductase
TRAD_RS12100	COG2271	Major facilitator Superfamily
TRAD_RS12115	COG0438	transferase activity, transferring glycosyl groups
TRAD_RS12160	COG1175	transmembrane transport
TRAD_RS12165	COG0395	ABC-type sugar transport system, permease component
TRAD_RS12190	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TRAD_RS12195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TRAD_RS12205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TRAD_RS12220	COG2199	diguanylate cyclase activity
TRAD_RS12220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TRAD_RS12255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS12260	COG2326	polyphosphate kinase activity
TRAD_RS12280	COG1177	transmembrane transport
TRAD_RS12320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TRAD_RS12325	COG0085	RNA polymerase activity
TRAD_RS12330	COG0222	ribosome binding
TRAD_RS12335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TRAD_RS12340	COG0081	regulation of translation
TRAD_RS12345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TRAD_RS12350	COG0250	Participates in transcription elongation, termination and antitermination
TRAD_RS12355	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TRAD_RS12360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TRAD_RS12365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TRAD_RS12390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TRAD_RS12390	COG1796	DNA polymerase
TRAD_RS12400	COG0717	Belongs to the dCTP deaminase family
TRAD_RS12405	COG2205	protein histidine kinase activity
TRAD_RS12410	COG0745	RESPONSE REGULATOR receiver
TRAD_RS12430	COG1215	transferase activity, transferring glycosyl groups
TRAD_RS12455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TRAD_RS12460	COG0686	Belongs to the AlaDH PNT family
TRAD_RS12470	COG0632	four-way junction helicase activity
TRAD_RS12475	COG1193	negative regulation of DNA recombination
TRAD_RS12500	COG1611	Belongs to the LOG family
TRAD_RS12510	COG4585	Histidine kinase
TRAD_RS12525	COG1404	Belongs to the peptidase S8 family
TRAD_RS12545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TRAD_RS12590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TRAD_RS12605	COG0667	Aldo Keto reductase
TRAD_RS12665	COG1132	(ABC) transporter
TRAD_RS12670	COG1764	response to oxidative stress
TRAD_RS12680	COG0556	nucleotide-excision repair
TRAD_RS12695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TRAD_RS12705	COG0793	Belongs to the peptidase S41A family
TRAD_RS12705	COG3409	Peptidoglycan-binding domain 1 protein
TRAD_RS12715	COG3263	regulation of cellular component size
TRAD_RS12720	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TRAD_RS12730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TRAD_RS12740	COG0012	GTP binding
TRAD_RS12745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TRAD_RS12750	COG1268	BioY protein
TRAD_RS12765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TRAD_RS12775	COG0237	dephospho-CoA kinase activity
TRAD_RS12780	COG0617	tRNA 3'-terminal CCA addition
TRAD_RS12785	COG0628	permease
TRAD_RS12800	COG0436	Aminotransferase
TRAD_RS12835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TRAD_RS12845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TRAD_RS12870	COG0442	prolyl-tRNA aminoacylation
TRAD_RS12880	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS12885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TRAD_RS12890	COG0747	negative chemotaxis
TRAD_RS12900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS12915	COG0539	negative regulation of cytoplasmic translation
TRAD_RS12920	COG1704	LemA family
TRAD_RS12925	COG0482	sulfurtransferase activity
TRAD_RS12935	COG1494	fructose-1,6-bisphosphatase
TRAD_RS12940	COG0140	phosphoribosyl-ATP diphosphatase activity
TRAD_RS12940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TRAD_RS12945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TRAD_RS12950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TRAD_RS12955	COG0151	Belongs to the GarS family
TRAD_RS12970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TRAD_RS12985	COG0585	pseudouridine synthase activity
TRAD_RS12995	COG5002	protein histidine kinase activity
TRAD_RS13000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TRAD_RS13005	COG1774	PSP1 C-terminal conserved region
TRAD_RS13020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TRAD_RS13035	COG3842	ATPase activity
TRAD_RS13060	COG0395	ABC-type sugar transport system, permease component
TRAD_RS13070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TRAD_RS13070	COG0316	Belongs to the HesB IscA family
TRAD_RS13075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TRAD_RS13110	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TRAD_RS13130	COG0702	epimerase
TRAD_RS13135	COG0142	geranyltranstransferase activity
TRAD_RS13180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TRAD_RS13180	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TRAD_RS13195	COG4948	Mandelate Racemase Muconate Lactonizing
TRAD_RS13210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TRAD_RS13220	COG0346	lactoylglutathione lyase activity
TRAD_RS13225	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TRAD_RS13230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TRAD_RS13250	COG1840	ABC-type Fe3 transport system, periplasmic component
TRAD_RS13260	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TRAD_RS13265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TRAD_RS13275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TRAD_RS13285	COG0328	RNA-DNA hybrid ribonuclease activity
TRAD_RS13300	COG2197	response regulator
TRAD_RS13305	COG0641	radical SAM
TRAD_RS13325	COG0589	response to stress
TRAD_RS13325	COG0475	glutathione-regulated potassium exporter activity
TRAD_RS13330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TRAD_RS13335	COG1320	monovalent cation:proton antiporter activity
TRAD_RS13340	COG2212	antiporter activity
TRAD_RS13345	COG1863	multisubunit Na H antiporter MnhE subunit
TRAD_RS13350	COG0651	ATP synthesis coupled electron transport
TRAD_RS13355	COG1006	Multisubunit Na H antiporter MnhC subunit
TRAD_RS13360	COG2111	Na H antiporter
TRAD_RS13365	COG2111	Na H antiporter
TRAD_RS13365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TRAD_RS13380	COG1160	GTP binding
TRAD_RS13405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TRAD_RS13430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS13435	COG0601	transmembrane transport
TRAD_RS13440	COG0747	negative chemotaxis
TRAD_RS13445	COG0667	Aldo Keto reductase
TRAD_RS13450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TRAD_RS13455	COG0525	valine-tRNA ligase activity
TRAD_RS13465	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TRAD_RS13470	COG0300	oxidoreductase activity
TRAD_RS13480	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TRAD_RS13485	COG0167	dihydroorotate dehydrogenase activity
TRAD_RS13490	COG1321	iron dependent repressor
TRAD_RS13495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TRAD_RS13495	COG0546	phosphoglycolate phosphatase activity
TRAD_RS13505	COG4221	oxidoreductase activity
TRAD_RS13530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TRAD_RS13565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TRAD_RS13575	COG2211	Major facilitator Superfamily
TRAD_RS13605	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TRAD_RS13620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TRAD_RS13630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TRAD_RS13645	COG0537	adenosine 5'-monophosphoramidase activity
TRAD_RS13650	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TRAD_RS13655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TRAD_RS13675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TRAD_RS13730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TRAD_RS13740	COG0204	Acyl-transferase
TRAD_RS13745	COG0776	regulation of translation
TRAD_RS13750	COG1760	l-serine dehydratase
TRAD_RS13755	COG1760	l-serine dehydratase
TRAD_RS13760	COG1252	NADH dehydrogenase
TRAD_RS13765	COG0483	inositol monophosphate 1-phosphatase activity
TRAD_RS13780	COG1959	2 iron, 2 sulfur cluster binding
TRAD_RS13785	COG0604	alcohol dehydrogenase
TRAD_RS13785	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS13785	COG3321	synthase
TRAD_RS13790	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TRAD_RS13795	COG0287	Prephenate dehydrogenase
TRAD_RS13805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TRAD_RS13810	COG1408	metallophosphoesterase
TRAD_RS13820	COG0183	Belongs to the thiolase family
TRAD_RS13840	COG4572	Cation transport regulator
TRAD_RS13845	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS13855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TRAD_RS13855	COG1845	cytochrome c oxidase, subunit III
TRAD_RS13860	COG2010	Cytochrome c
TRAD_RS13860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TRAD_RS13865	COG0109	protoheme IX farnesyltransferase activity
TRAD_RS13865	COG1612	heme a metabolic process
TRAD_RS13870	COG1612	heme a metabolic process
TRAD_RS13870	COG0109	protoheme IX farnesyltransferase activity
TRAD_RS13890	COG0052	Belongs to the universal ribosomal protein uS2 family
TRAD_RS13895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TRAD_RS13900	COG0528	UMP kinase activity
TRAD_RS13905	COG0233	cytoplasmic translational termination
TRAD_RS13910	COG0575	Belongs to the CDS family
TRAD_RS13920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TRAD_RS13925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TRAD_RS13930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TRAD_RS13940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TRAD_RS13945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TRAD_RS13955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TRAD_RS13965	COG1307	EDD domain protein, DegV family
TRAD_RS13980	COG2010	Cytochrome c
TRAD_RS13980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TRAD_RS13985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TRAD_RS13990	COG1845	cytochrome c oxidase, subunit III
TRAD_RS14030	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TRAD_RS14035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TRAD_RS14045	COG0512	Glutamine amidotransferase of anthranilate synthase
TRAD_RS14050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TRAD_RS14080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TRAD_RS14090	COG1428	Deoxynucleoside kinase
TRAD_RS14095	COG1428	Deoxynucleoside kinase
TRAD_RS14100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TRAD_RS14140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TRAD_RS14145	COG0473	3-isopropylmalate dehydrogenase activity
TRAD_RS14155	COG2177	Part of the ABC transporter FtsEX involved in
TRAD_RS14175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TRAD_RS14185	COG0402	S-adenosylhomocysteine deaminase activity
TRAD_RS14195	COG0494	nUDIX hydrolase
TRAD_RS14215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TRAD_RS14245	COG0438	transferase activity, transferring glycosyl groups
TRAD_RS14265	COG1091	dTDP-4-dehydrorhamnose reductase activity
TRAD_RS14270	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TRAD_RS14280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TRAD_RS14300	COG1674	ftsk spoiiie
TRAD_RS14305	COG0628	permease
TRAD_RS14315	COG0395	ABC-type sugar transport system, permease component
TRAD_RS14320	COG1175	transmembrane transport
TRAD_RS14330	COG1609	Transcriptional regulator
TRAD_RS14350	COG0123	including yeast histone deacetylase and acetoin utilization protein
TRAD_RS14365	COG1063	alcohol dehydrogenase
TRAD_RS14370	COG1063	alcohol dehydrogenase
TRAD_RS14375	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS14390	COG0395	ABC-type sugar transport system, permease component
TRAD_RS14395	COG1063	alcohol dehydrogenase
TRAD_RS14400	COG1063	alcohol dehydrogenase
TRAD_RS14405	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TRAD_RS14450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TRAD_RS14475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRAD_RS14480	COG0601	transmembrane transport
TRAD_RS14510	COG2084	Dehydrogenase
TRAD_RS14515	COG0071	Belongs to the small heat shock protein (HSP20) family
TRAD_RS14525	COG4106	trans-aconitate 2-methyltransferase activity
TRAD_RS14540	COG0459	protein refolding
TRAD_RS14545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TRAD_RS14560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TRAD_RS14560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TRAD_RS14580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TRAD_RS14585	COG2205	protein histidine kinase activity
TRAD_RS14590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TRAD_RS14595	COG0497	DNA recombination
TRAD_RS14600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TRAD_RS14610	COG0656	L-ascorbic acid biosynthetic process
TRAD_RS14655	COG1022	Amp-dependent synthetase and ligase
TRAD_RS14660	COG1960	acyl-CoA dehydrogenase activity
TRAD_RS14670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TRAD_RS14700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TRAD_RS14720	COG0728	peptidoglycan biosynthetic process
TRAD_RS14725	COG1028	Short-chain dehydrogenase reductase Sdr
TRAD_RS14725	COG3347	Dehydrogenase
TRAD_RS14730	COG1556	Lactate utilization protein
TRAD_RS14735	COG1139	Iron-sulfur cluster binding protein
TRAD_RS14740	COG0247	lactate metabolic process
TRAD_RS14755	COG3118	belongs to the thioredoxin family
TRAD_RS14760	COG0534	Mate efflux family protein
TRAD_RS14765	COG0436	Aminotransferase
TRAD_RS14770	COG0105	UTP biosynthetic process
TRAD_RS14780	COG1007	ATP synthesis coupled electron transport
TRAD_RS14785	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TRAD_RS14790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TRAD_RS14795	COG0713	ATP synthesis coupled electron transport
TRAD_RS14800	COG0839	Belongs to the complex I subunit 6 family
TRAD_RS14805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TRAD_RS14810	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TRAD_RS14815	COG1034	ATP synthesis coupled electron transport
TRAD_RS14820	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TRAD_RS14825	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TRAD_RS14835	COG0649	NAD binding
TRAD_RS14840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TRAD_RS14845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TRAD_RS14850	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TRAD_RS14855	COG0735	belongs to the Fur family
TRAD_RS14860	COG0039	L-malate dehydrogenase activity
TRAD_RS14865	COG1475	DNA binding
TRAD_RS14870	COG1192	Involved in chromosome partitioning
TRAD_RS14880	COG0445	tRNA wobble uridine modification
TRAD_RS14890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TRAD_RS14900	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TRAD_RS14910	COG1309	transcriptional regulator
TRAD_RS14940	COG3206	protein involved in exopolysaccharide biosynthesis
TRAD_RS14945	COG1366	Belongs to the anti-sigma-factor antagonist family
TRAD_RS14965	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TRAD_RS14970	COG0706	membrane insertase activity
TRAD_RS15000	COG0544	peptidyl-prolyl cis-trans isomerase activity
TRAD_RS15020	COG5001	Diguanylate cyclase
TRAD_RS15035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TRAD_RS15045	COG2197	response regulator
TRAD_RS15060	COG0671	phosphoesterase, PA-phosphatase related
TRAD_RS15120	COG0590	tRNA wobble adenosine to inosine editing
TRAD_RS15120	COG0037	tRNA processing
TRAD_RS15130	COG1752	Esterase of the alpha-beta hydrolase superfamily
TRAD_RS15180	COG0739	heme binding
TRAD_RS15185	COG4585	Histidine kinase
TRAD_RS15195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TRAD_RS15225	COG2197	response regulator
TRAD_RS15235	COG3850	Histidine kinase
TRAD_RS15235	COG5002	protein histidine kinase activity
TRAD_RS15295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TRAD_RS15300	COG0463	Glycosyl transferase, family 2
TRAD_RS15305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TRAD_RS15305	COG2199	diguanylate cyclase activity
TRAD_RS15315	COG4597	amino acid ABC transporter
TRAD_RS15320	COG0668	transmembrane transport
TRAD_RS15375	COG0842	Transport permease protein
TRAD_RS15375	COG1129	ABC transporter
TRAD_RS15390	COG1470	cell adhesion involved in biofilm formation
TRAD_RS15410	COG0765	amino acid transport
TRAD_RS15420	COG3547	Transposase (IS116 IS110 IS902 family)
TRAD_RS15445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TRAD_RS15465	COG2202	Pas domain
TRAD_RS15465	COG1366	Belongs to the anti-sigma-factor antagonist family
TRAD_RS15470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TRAD_RS15495	COG0860	N-Acetylmuramoyl-L-alanine amidase
TRAD_RS15520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TRAD_RS15530	COG0357	Ribosomal RNA small subunit methyltransferase G