locus-tag	class	description
AN946_RS00010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN946_RS00015	COG0154	amidase activity
AN946_RS00020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN946_RS00025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN946_RS00030	COG1404	Belongs to the peptidase S8 family
AN946_RS00040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN946_RS00050	COG1397	ADP-ribosylglycohydrolase
AN946_RS00060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AN946_RS00065	COG2135	peptidase activity
AN946_RS00070	COG4585	Histidine kinase
AN946_RS00105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AN946_RS00130	COG1053	succinate dehydrogenase
AN946_RS00140	COG0387	Pfam Sodium calcium exchanger
AN946_RS00150	COG1131	(ABC) transporter
AN946_RS00155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN946_RS00175	COG0366	Alpha amylase catalytic
AN946_RS00175	COG1470	cell adhesion involved in biofilm formation
AN946_RS00180	COG1615	UPF0182 protein
AN946_RS00220	COG0180	Tryptophanyl-tRNA synthetase
AN946_RS00225	COG0058	SHG alpha-glucan phosphorylase activity
AN946_RS00255	COG0366	Alpha amylase catalytic
AN946_RS00260	COG0366	Alpha amylase catalytic
AN946_RS00265	COG3281	Trehalose synthase
AN946_RS00270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AN946_RS00280	COG3833	ABC-type maltose transport systems, permease component
AN946_RS00285	COG1175	transmembrane transport
AN946_RS00295	COG1609	Transcriptional regulator
AN946_RS00340	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AN946_RS00350	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AN946_RS00355	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AN946_RS00360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AN946_RS00365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AN946_RS00370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AN946_RS00375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AN946_RS00380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AN946_RS00385	COG0356	it plays a direct role in the translocation of protons across the membrane
AN946_RS00410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AN946_RS00425	COG0083	homoserine kinase activity
AN946_RS00430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AN946_RS00435	COG0460	homoserine dehydrogenase
AN946_RS00445	COG0018	arginyl-trna synthetase
AN946_RS00485	COG0584	glycerophosphoryl diester phosphodiesterase
AN946_RS00490	COG0739	heme binding
AN946_RS00500	COG1253	flavin adenine dinucleotide binding
AN946_RS00505	COG0567	Dehydrogenase, E1 component
AN946_RS00505	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN946_RS00515	COG0791	NLP P60 protein
AN946_RS00515	COG3103	Sh3 type 3 domain protein
AN946_RS00515	COG1388	LysM domain
AN946_RS00530	COG1595	DNA-templated transcription, initiation
AN946_RS00540	COG0363	glucosamine-6-phosphate deaminase activity
AN946_RS00545	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AN946_RS00555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN946_RS00560	COG4608	Belongs to the ABC transporter superfamily
AN946_RS00565	COG0444	Belongs to the ABC transporter superfamily
AN946_RS00585	COG0657	acetylesterase activity
AN946_RS00610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AN946_RS00615	COG1162	GTPase activity
AN946_RS00620	COG0483	inositol monophosphate 1-phosphatase activity
AN946_RS00625	COG0420	3'-5' exonuclease activity
AN946_RS00630	COG0419	ATPase involved in DNA repair
AN946_RS00660	COG1652	LysM domain
AN946_RS00660	COG2823	Periplasmic or secreted lipoprotein
AN946_RS00670	COG0653	protein targeting
AN946_RS00675	COG0142	geranyltranstransferase activity
AN946_RS00680	COG1007	ATP synthesis coupled electron transport
AN946_RS00690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AN946_RS00695	COG0713	ATP synthesis coupled electron transport
AN946_RS00700	COG0839	Belongs to the complex I subunit 6 family
AN946_RS00705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN946_RS00710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AN946_RS00715	COG1034	ATP synthesis coupled electron transport
AN946_RS00720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AN946_RS00730	COG0649	NAD binding
AN946_RS00735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN946_RS00740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN946_RS00750	COG0644	oxidoreductase
AN946_RS00755	COG2226	methyltransferase
AN946_RS00760	COG1169	isochorismate synthase
AN946_RS00765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN946_RS00770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AN946_RS00775	COG4948	Mandelate Racemase Muconate Lactonizing
AN946_RS00780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AN946_RS00790	COG1175	transmembrane transport
AN946_RS00795	COG0395	ABC-type sugar transport system, permease component
AN946_RS00820	COG0406	alpha-ribazole phosphatase activity
AN946_RS00825	COG1846	Transcriptional regulator
AN946_RS00835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN946_RS00840	COG0569	domain protein
AN946_RS00845	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AN946_RS00855	COG1194	a g-specific adenine glycosylase
AN946_RS00870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AN946_RS00875	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AN946_RS00880	COG0247	lactate metabolic process
AN946_RS00885	COG3386	PFAM SMP-30 Gluconolaconase
AN946_RS00895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AN946_RS00900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN946_RS00905	COG2409	Drug exporters of the RND superfamily
AN946_RS00910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AN946_RS00920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AN946_RS00925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AN946_RS00935	COG2376	Dihydroxyacetone kinase
AN946_RS00940	COG1461	Dihydroxyacetone kinase
AN946_RS00945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN946_RS00945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN946_RS00955	COG3250	beta-galactosidase activity
AN946_RS00975	COG1609	Transcriptional regulator
AN946_RS01005	COG0302	gtp cyclohydrolase
AN946_RS01010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN946_RS01020	COG0037	tRNA processing
AN946_RS01035	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AN946_RS01040	COG0791	NLP P60 protein
AN946_RS01045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN946_RS01050	COG2267	carboxylic ester hydrolase activity
AN946_RS01060	COG0247	lactate metabolic process
AN946_RS01060	COG0277	FAD linked oxidase domain protein
AN946_RS01065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN946_RS01065	COG0574	Belongs to the PEP-utilizing enzyme family
AN946_RS01080	COG1175	transmembrane transport
AN946_RS01085	COG0395	ABC-type sugar transport system, permease component
AN946_RS01090	COG0366	Alpha amylase catalytic
AN946_RS01110	COG5290	Psort location Cytoplasmic, score
AN946_RS01115	COG1715	Restriction endonuclease
AN946_RS01135	COG1285	pathogenesis
AN946_RS01140	COG2271	Major facilitator Superfamily
AN946_RS01145	COG1609	Transcriptional regulator
AN946_RS01160	COG0737	Belongs to the 5'-nucleotidase family
AN946_RS01180	COG1116	anion transmembrane transporter activity
AN946_RS01185	COG2226	methyltransferase
AN946_RS01190	COG1609	Transcriptional regulator
AN946_RS01195	COG1129	ABC transporter
AN946_RS01200	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN946_RS01205	COG1879	ABC-type sugar transport system periplasmic component
AN946_RS01210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN946_RS01215	COG1869	D-ribose catabolic process
AN946_RS01220	COG3250	beta-galactosidase activity
AN946_RS01225	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AN946_RS01245	COG2610	gluconate transmembrane transporter activity
AN946_RS01250	COG1609	Transcriptional regulator
AN946_RS01260	COG3250	beta-galactosidase activity
AN946_RS01280	COG3119	arylsulfatase activity
AN946_RS01285	COG1609	Transcriptional regulator
AN946_RS01290	COG2814	Major facilitator Superfamily
AN946_RS01295	COG0641	radical SAM
AN946_RS01300	COG0730	response to heat
AN946_RS01305	COG0698	ribose 5-phosphate isomerase
AN946_RS01315	COG2376	Dihydroxyacetone kinase
AN946_RS01320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AN946_RS01330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN946_RS01345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AN946_RS01350	COG1349	DNA-binding transcription factor activity
AN946_RS01370	COG2390	Transcriptional regulator
AN946_RS01375	COG0738	Major facilitator superfamily
AN946_RS01395	COG1490	D-aminoacyl-tRNA deacylase activity
AN946_RS01405	COG0354	folic acid binding
AN946_RS01410	COG3485	protocatechuate 3,4-dioxygenase
AN946_RS01420	COG0737	Belongs to the 5'-nucleotidase family
AN946_RS01430	COG1115	amino acid carrier protein
AN946_RS01440	COG0306	phosphate transporter
AN946_RS01445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AN946_RS01465	COG0406	alpha-ribazole phosphatase activity
AN946_RS01465	COG0494	nUDIX hydrolase
AN946_RS01470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AN946_RS01495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN946_RS01520	COG0728	peptidoglycan biosynthetic process
AN946_RS01525	COG0039	L-malate dehydrogenase activity
AN946_RS01555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN946_RS01585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN946_RS01590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AN946_RS01595	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AN946_RS01600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AN946_RS01610	COG0191	fructose-bisphosphate aldolase activity
AN946_RS01625	COG0494	nUDIX hydrolase
AN946_RS01670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN946_RS01680	COG1506	peptidase
AN946_RS01680	COG0823	Involved in the tonB-independent uptake of proteins
AN946_RS01685	COG0584	glycerophosphoryl diester phosphodiesterase
AN946_RS01705	COG0789	Transcriptional regulator
AN946_RS01710	COG0484	heat shock protein binding
AN946_RS01715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AN946_RS01720	COG0443	Heat shock 70 kDa protein
AN946_RS01725	COG0167	dihydroorotate dehydrogenase activity
AN946_RS01730	COG0167	dihydroorotate dehydrogenase activity
AN946_RS01735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AN946_RS01740	COG0284	orotidine-5'-phosphate decarboxylase activity
AN946_RS01755	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AN946_RS01765	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN946_RS01770	COG1937	Protein conserved in bacteria
AN946_RS01775	COG0243	molybdopterin cofactor binding
AN946_RS01780	COG0437	4 iron, 4 sulfur cluster binding
AN946_RS01790	COG1505	serine-type exopeptidase activity
AN946_RS01800	COG0390	transport system, permease component
AN946_RS01805	COG1940	carbohydrate kinase activity
AN946_RS01840	COG0662	Cupin 2, conserved barrel domain protein
AN946_RS01860	COG3842	ATPase activity
AN946_RS01865	COG4149	molybdate abc transporter
AN946_RS01895	COG0651	ATP synthesis coupled electron transport
AN946_RS01900	COG1006	Multisubunit Na H antiporter MnhC subunit
AN946_RS01905	COG2111	Na H antiporter
AN946_RS01905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AN946_RS01910	COG0717	Belongs to the dCTP deaminase family
AN946_RS01920	COG2963	transposase activity
AN946_RS01925	COG2801	Transposase and inactivated derivatives
AN946_RS01940	COG2801	Transposase and inactivated derivatives
AN946_RS01975	COG0732	type I restriction modification DNA specificity domain
AN946_RS02025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AN946_RS02030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AN946_RS02035	COG1754	DNA topoisomerase type I activity
AN946_RS02035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AN946_RS02040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AN946_RS02040	COG2890	protein-(glutamine-N5) methyltransferase activity
AN946_RS02050	COG3655	Transcriptional regulator
AN946_RS02100	COG2267	carboxylic ester hydrolase activity
AN946_RS02135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN946_RS02160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AN946_RS02170	COG0315	cyclic pyranopterin monophosphate synthase activity
AN946_RS02180	COG0521	Mo-molybdopterin cofactor biosynthetic process
AN946_RS02230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AN946_RS02235	COG4868	Belongs to the UPF0371 family
AN946_RS02255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AN946_RS02280	COG0077	Prephenate dehydratase
AN946_RS02290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AN946_RS02295	COG0561	phosphatase activity
AN946_RS02320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN946_RS02325	COG1879	ABC-type sugar transport system periplasmic component
AN946_RS02330	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN946_RS02360	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AN946_RS02375	COG1487	ribonuclease activity
AN946_RS02410	COG0395	ABC-type sugar transport system, permease component
AN946_RS02415	COG1175	transmembrane transport
AN946_RS02430	COG1609	Transcriptional regulator
AN946_RS02435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AN946_RS02440	COG1132	(ABC) transporter
AN946_RS02460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_RS02470	COG1120	ATPase activity
AN946_RS02480	COG2226	methyltransferase
AN946_RS02485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN946_RS02490	COG0800	Aldolase
AN946_RS02495	COG1312	Catalyzes the dehydration of D-mannonate
AN946_RS02500	COG0246	Mannitol dehydrogenase
AN946_RS02505	COG1414	Transcriptional regulator
AN946_RS02510	COG1136	(ABC) transporter
AN946_RS02510	COG0577	efflux transmembrane transporter activity
AN946_RS02530	COG1328	CTP reductase activity
AN946_RS02540	COG2197	response regulator
AN946_RS02550	COG1136	(ABC) transporter
AN946_RS02560	COG1131	(ABC) transporter
AN946_RS02570	COG4585	Histidine kinase
AN946_RS02575	COG2197	response regulator
AN946_RS02580	COG1643	Atp-dependent helicase
AN946_RS02605	COG1175	transmembrane transport
AN946_RS02610	COG0395	ABC-type sugar transport system, permease component
AN946_RS02630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN946_RS02640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AN946_RS02645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN946_RS02650	COG1780	Probably involved in ribonucleotide reductase function
AN946_RS02665	COG1854	S-ribosylhomocysteine lyase activity
AN946_RS02670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AN946_RS02700	COG0842	Transport permease protein
AN946_RS02700	COG1131	(ABC) transporter
AN946_RS02700	COG1716	ATPase activity
AN946_RS02705	COG1716	ATPase activity
AN946_RS02730	COG3764	Sortase (surface protein transpeptidase)
AN946_RS02740	COG0705	Rhomboid family
AN946_RS02740	COG0457	Tetratricopeptide repeat
AN946_RS02825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AN946_RS02830	COG0187	DNA topoisomerase II activity
AN946_RS02840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AN946_RS02845	COG0592	DNA-directed DNA polymerase activity
AN946_RS02850	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN946_RS02855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AN946_RS02860	COG0594	ribonuclease P activity
AN946_RS02865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AN946_RS02870	COG0706	membrane insertase activity
AN946_RS02880	COG0357	Ribosomal RNA small subunit methyltransferase G
AN946_RS02885	COG1192	Involved in chromosome partitioning
AN946_RS02895	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN946_RS02900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN946_RS02905	COG0492	ferredoxin-NADP+ reductase activity
AN946_RS02925	COG0617	tRNA 3'-terminal CCA addition
AN946_RS02935	COG0628	permease
AN946_RS02940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN946_RS02945	COG0360	Binds together with S18 to 16S ribosomal RNA
AN946_RS02955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AN946_RS02960	COG0359	binds to the 23S rRNA
AN946_RS02980	COG0305	Participates in initiation and elongation during chromosome replication
AN946_RS02985	COG2814	Major facilitator Superfamily
AN946_RS02995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AN946_RS03010	COG0351	phosphomethylpyrimidine kinase
AN946_RS03055	COG1428	Deoxynucleoside kinase
AN946_RS03065	COG0343	queuine tRNA-ribosyltransferase activity
AN946_RS03070	COG0745	RESPONSE REGULATOR receiver
AN946_RS03085	COG0577	efflux transmembrane transporter activity
AN946_RS03115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN946_RS03130	COG1643	Atp-dependent helicase
AN946_RS03170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AN946_RS03175	COG1252	NADH dehydrogenase
AN946_RS03200	COG1070	Carbohydrate kinase
AN946_RS03210	COG1879	ABC-type sugar transport system periplasmic component
AN946_RS03220	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN946_RS03255	COG0471	metal ion transport
AN946_RS03270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AN946_RS03275	COG1129	ABC transporter
AN946_RS03280	COG2375	cellular response to nickel ion
AN946_RS03280	COG1132	(ABC) transporter
AN946_RS03285	COG1132	(ABC) transporter
AN946_RS03315	COG1175	transmembrane transport
AN946_RS03325	COG1846	Transcriptional regulator
AN946_RS03325	COG1940	carbohydrate kinase activity
AN946_RS03330	COG1940	carbohydrate kinase activity
AN946_RS03340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN946_RS03345	COG0601	transmembrane transport
AN946_RS03355	COG1940	carbohydrate kinase activity
AN946_RS03370	COG3142	Participates in the control of copper homeostasis
AN946_RS03385	COG1904	glucuronate isomerase
AN946_RS03390	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN946_RS03395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN946_RS03395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN946_RS03405	COG0156	8-amino-7-oxononanoate synthase activity
AN946_RS03410	COG1063	alcohol dehydrogenase
AN946_RS03415	COG0395	ABC-type sugar transport system, permease component
AN946_RS03420	COG1175	transmembrane transport
AN946_RS03430	COG0673	inositol 2-dehydrogenase activity
AN946_RS03435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AN946_RS03440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN946_RS03445	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_RS03450	COG4605	iron ion homeostasis
AN946_RS03455	COG4604	ABC transporter, ATP-binding protein
AN946_RS03465	COG3962	Belongs to the TPP enzyme family
AN946_RS03470	COG3718	enzyme involved in inositol metabolism
AN946_RS03490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN946_RS03495	COG0673	inositol 2-dehydrogenase activity
AN946_RS03505	COG0673	inositol 2-dehydrogenase activity
AN946_RS03515	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN946_RS03520	COG1879	ABC-type sugar transport system periplasmic component
AN946_RS03525	COG0483	inositol monophosphate 1-phosphatase activity
AN946_RS03530	COG2271	Major facilitator Superfamily
AN946_RS03540	COG1063	alcohol dehydrogenase
AN946_RS03555	COG1129	ABC transporter
AN946_RS03560	COG2375	cellular response to nickel ion
AN946_RS03560	COG1132	(ABC) transporter
AN946_RS03570	COG1309	transcriptional regulator
AN946_RS03605	COG0586	Pfam SNARE associated Golgi protein
AN946_RS03610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AN946_RS03615	COG1950	PFAM Membrane protein of
AN946_RS03620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN946_RS03635	COG0710	3-dehydroquinate dehydratase activity
AN946_RS03645	COG0667	Aldo Keto reductase
AN946_RS03650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AN946_RS03680	COG1175	transmembrane transport
AN946_RS03685	COG0395	ABC-type sugar transport system, permease component
AN946_RS03695	COG3345	alpha-galactosidase
AN946_RS03710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_RS03715	COG1120	ATPase activity
AN946_RS03760	COG0588	phosphoglycerate mutase activity
AN946_RS03770	COG5002	protein histidine kinase activity
AN946_RS03785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AN946_RS03790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AN946_RS03820	COG3775	system Galactitol-specific IIC component
AN946_RS03835	COG2376	Dihydroxyacetone kinase
AN946_RS03870	COG0215	cysteine-tRNA ligase activity
AN946_RS03875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN946_RS03890	COG2233	PERMEase
AN946_RS03910	COG1966	Carbon starvation protein
AN946_RS03925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AN946_RS03955	COG1175	transmembrane transport
AN946_RS03960	COG1653	transport
AN946_RS03970	COG0673	inositol 2-dehydrogenase activity
AN946_RS03980	COG3842	ATPase activity
AN946_RS04015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AN946_RS04030	COG0459	protein refolding
AN946_RS04040	COG0300	oxidoreductase activity
AN946_RS04050	COG2205	protein histidine kinase activity
AN946_RS04055	COG0745	RESPONSE REGULATOR receiver
AN946_RS04065	COG1842	Phage shock protein A
AN946_RS04075	COG1278	Cold shock
AN946_RS04090	COG2252	PERMEase
AN946_RS04095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AN946_RS04105	COG0791	NLP P60 protein
AN946_RS04105	COG1388	LysM domain
AN946_RS04190	COG0596	Alpha beta hydrolase
AN946_RS04200	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AN946_RS04205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_RS04210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_RS04215	COG1120	ATPase activity
AN946_RS04220	COG2188	Transcriptional regulator
AN946_RS04225	COG0657	acetylesterase activity
AN946_RS04230	COG0477	Major facilitator Superfamily
AN946_RS04245	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AN946_RS04250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN946_RS04255	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AN946_RS04260	COG0254	rRNA binding
AN946_RS04265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AN946_RS04280	COG3830	Belongs to the UPF0237 family
AN946_RS04285	COG2848	UPF0210 protein
AN946_RS04295	COG1511	domain protein
AN946_RS04310	COG3711	transcriptional antiterminator
AN946_RS04320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN946_RS04330	COG1051	belongs to the nudix hydrolase family
AN946_RS04345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN946_RS04345	COG1263	PTS System
AN946_RS04355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN946_RS04375	COG1556	Lactate utilization protein
AN946_RS04385	COG0247	lactate metabolic process
AN946_RS04390	COG1620	l-lactate permease
AN946_RS04415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN946_RS04420	COG2813	Specifically methylates the guanine in position
AN946_RS04435	COG1131	(ABC) transporter
AN946_RS04450	COG2873	o-acetylhomoserine
AN946_RS04470	COG1335	isochorismatase
AN946_RS04480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN946_RS04485	COG0084	hydrolase, TatD family'
AN946_RS04495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AN946_RS04500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AN946_RS04505	COG0488	(ABC) transporter
AN946_RS04515	COG1668	transmembrane transport
AN946_RS04520	COG4152	abc transporter atp-binding protein
AN946_RS04535	COG1309	transcriptional regulator
AN946_RS04545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AN946_RS04555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AN946_RS04560	COG0193	aminoacyl-tRNA hydrolase activity
AN946_RS04575	COG0148	phosphopyruvate hydratase activity
AN946_RS04595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN946_RS04620	COG1725	Transcriptional regulator
AN946_RS04625	COG1131	(ABC) transporter
AN946_RS04640	COG1012	belongs to the aldehyde dehydrogenase family
AN946_RS04645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN946_RS04660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN946_RS04665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN946_RS04670	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AN946_RS04680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN946_RS04685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN946_RS04690	COG1722	exodeoxyribonuclease VII activity
AN946_RS04700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AN946_RS04710	COG4555	ABC transporter
AN946_RS04725	COG1162	GTPase activity
AN946_RS04730	COG1322	Protein conserved in bacteria
AN946_RS04735	COG0012	GTP binding
AN946_RS04760	COG0477	Major facilitator Superfamily
AN946_RS04775	COG0366	Alpha amylase catalytic
AN946_RS04780	COG1653	transport
AN946_RS04790	COG0395	ABC-type sugar transport system, permease component
AN946_RS04810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AN946_RS04815	COG0549	Belongs to the carbamate kinase family
AN946_RS04820	COG1834	amidinotransferase
AN946_RS04830	COG0477	Major facilitator Superfamily
AN946_RS04835	COG3226	Transcriptional regulator
AN946_RS04840	COG0431	NADPH-dependent FMN reductase
AN946_RS04850	COG1780	Probably involved in ribonucleotide reductase function
AN946_RS04880	COG1970	mechanosensitive ion channel activity
AN946_RS04885	COG0242	peptide deformylase activity
AN946_RS04895	COG2116	formate transmembrane transporter activity
AN946_RS04910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN946_RS04915	COG0444	Belongs to the ABC transporter superfamily
AN946_RS04920	COG4608	Belongs to the ABC transporter superfamily
AN946_RS04950	COG1846	Transcriptional regulator
AN946_RS04950	COG1940	carbohydrate kinase activity
AN946_RS04955	COG1175	transmembrane transport
AN946_RS04960	COG0395	ABC-type sugar transport system, permease component
AN946_RS04970	COG1501	Belongs to the glycosyl hydrolase 31 family
AN946_RS04975	COG0366	Alpha amylase catalytic
AN946_RS04980	COG0425	Belongs to the sulfur carrier protein TusA family
AN946_RS04985	COG2391	methyltransferase activity
AN946_RS04990	COG2838	Isocitrate dehydrogenase
AN946_RS05005	COG1362	aminopeptidase activity
AN946_RS05015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AN946_RS05020	COG0321	lipoyl(octanoyl) transferase activity
AN946_RS05050	COG1132	(ABC) transporter
AN946_RS05060	COG1217	gtp-binding protein TYPA
AN946_RS05095	COG0424	maF-like protein
AN946_RS05110	COG0745	RESPONSE REGULATOR receiver
AN946_RS05115	COG0642	Histidine kinase
AN946_RS05125	COG1316	TRANSCRIPTIONal
AN946_RS05130	COG1316	TRANSCRIPTIONal
AN946_RS05145	COG1088	dTDP-glucose 4,6-dehydratase activity
AN946_RS05170	COG0673	inositol 2-dehydrogenase activity
AN946_RS05265	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AN946_RS05325	COG0714	Associated with various cellular activities
AN946_RS05345	COG0745	RESPONSE REGULATOR receiver
AN946_RS05350	COG5002	protein histidine kinase activity
AN946_RS05350	COG5000	phosphorelay sensor kinase activity
AN946_RS05355	COG5401	PFAM Sporulation and spore germination
AN946_RS05360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AN946_RS05365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AN946_RS05375	COG1666	GTP binding
AN946_RS05395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN946_RS05410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AN946_RS05425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AN946_RS05435	COG0436	Aminotransferase
AN946_RS05450	COG0250	Participates in transcription elongation, termination and antitermination
AN946_RS05455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AN946_RS05460	COG0081	regulation of translation
AN946_RS05475	COG0572	uridine kinase
AN946_RS05480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AN946_RS05485	COG0222	ribosome binding
AN946_RS05490	COG0085	RNA polymerase activity
AN946_RS05495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AN946_RS05500	COG0833	amino acid
AN946_RS05505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AN946_RS05510	COG0049	tRNA binding
AN946_RS05515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AN946_RS05520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN946_RS05530	COG0546	phosphoglycolate phosphatase activity
AN946_RS05535	COG0051	transcription antitermination factor activity, RNA binding
AN946_RS05540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AN946_RS05545	COG0088	Forms part of the polypeptide exit tunnel
AN946_RS05550	COG0089	rRNA binding
AN946_RS05555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AN946_RS05560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AN946_RS05565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AN946_RS05570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AN946_RS05575	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AN946_RS05590	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AN946_RS05595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AN946_RS05600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AN946_RS05605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AN946_RS05610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AN946_RS05615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AN946_RS05625	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AN946_RS05630	COG1841	ribosomal large subunit assembly
AN946_RS05635	COG0200	Binds to the 23S rRNA
AN946_RS05645	COG0563	adenylate kinase activity
AN946_RS05655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AN946_RS05660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AN946_RS05670	COG0202	RNA polymerase activity
AN946_RS05675	COG0203	ribosomal protein L17
AN946_RS05680	COG1666	GTP binding
AN946_RS05685	COG0789	Transcriptional regulator
AN946_RS05690	COG4598	ABC transporter
AN946_RS05695	COG0765	amino acid transport
AN946_RS05705	COG1940	carbohydrate kinase activity
AN946_RS05710	COG0101	tRNA pseudouridine synthase activity
AN946_RS05730	COG1122	ATPase activity
AN946_RS05735	COG4720	Psort location CytoplasmicMembrane, score
AN946_RS05745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AN946_RS05750	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AN946_RS05760	COG1072	(Pantothenic acid kinase))
AN946_RS05765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AN946_RS05775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN946_RS05780	COG0802	atpase or kinase
AN946_RS05805	COG1053	succinate dehydrogenase
AN946_RS05810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AN946_RS05815	COG0733	neurotransmitter:sodium symporter activity
AN946_RS05820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AN946_RS05825	COG0428	transporter
AN946_RS05835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AN946_RS05845	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AN946_RS05850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AN946_RS05855	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AN946_RS05860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AN946_RS05865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AN946_RS05870	COG0151	Belongs to the GarS family
AN946_RS05875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AN946_RS05900	COG0516	GMP reductase activity
AN946_RS05905	COG0114	fumarate hydratase activity
AN946_RS05915	COG1136	(ABC) transporter
AN946_RS05930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AN946_RS05935	COG0857	belongs to the CobB CobQ family
AN946_RS05935	COG0280	phosphate acetyltransferase
AN946_RS05965	COG0653	protein targeting
AN946_RS05975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AN946_RS05975	COG2755	lipolytic protein G-D-S-L family
AN946_RS05980	COG0045	succinate-CoA ligase (ADP-forming) activity
AN946_RS06010	COG0205	6-phosphofructokinase activity
AN946_RS06015	COG0166	Belongs to the GPI family
AN946_RS06025	COG0039	L-malate dehydrogenase activity
AN946_RS06035	COG0110	maltose O-acetyltransferase activity
AN946_RS06065	COG2030	dehydratase
AN946_RS06070	COG2271	Major facilitator Superfamily
AN946_RS06075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN946_RS06090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AN946_RS06095	COG0644	oxidoreductase
AN946_RS06115	COG4770	biotin carboxylase activity
AN946_RS06120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AN946_RS06125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AN946_RS06135	COG1268	BioY protein
AN946_RS06145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AN946_RS06150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AN946_RS06165	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AN946_RS06165	COG0662	Cupin 2, conserved barrel domain protein
AN946_RS06170	COG1744	ABC transporter substrate-binding protein PnrA-like
AN946_RS06175	COG3845	ABC transporter
AN946_RS06180	COG4603	Belongs to the binding-protein-dependent transport system permease family
AN946_RS06185	COG1079	Belongs to the binding-protein-dependent transport system permease family
AN946_RS06205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AN946_RS06210	COG2814	Major facilitator Superfamily
AN946_RS06215	COG1309	transcriptional regulator
AN946_RS06220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN946_RS06230	COG1611	Belongs to the LOG family
AN946_RS06250	COG2239	Acts as a magnesium transporter
AN946_RS06255	COG0006	proline dipeptidase activity
AN946_RS06265	COG2095	MarC family integral membrane protein
AN946_RS06270	COG0513	Belongs to the DEAD box helicase family
AN946_RS06285	COG0210	DNA helicase
AN946_RS06330	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AN946_RS06335	COG2884	Cell division ATP-binding protein ftsE
AN946_RS06340	COG2177	Part of the ABC transporter FtsEX involved in
AN946_RS06345	COG0739	heme binding
AN946_RS06360	COG1619	proteins homologs of microcin C7 resistance protein MccF
AN946_RS06390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AN946_RS06455	COG1846	Transcriptional regulator
AN946_RS06470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN946_RS06495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AN946_RS06510	COG2985	domain, Protein
AN946_RS06510	COG0569	domain protein
AN946_RS06535	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AN946_RS06545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AN946_RS06555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AN946_RS06560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AN946_RS06585	COG1022	Amp-dependent synthetase and ligase
AN946_RS06590	COG0179	Fumarylacetoacetate (FAA) hydrolase
AN946_RS06645	COG0339	signal peptide processing
AN946_RS06650	COG4975	Glucose uptake
AN946_RS06660	COG0438	transferase activity, transferring glycosyl groups
AN946_RS06680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AN946_RS06685	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN946_RS06695	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AN946_RS06705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AN946_RS06720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AN946_RS06735	COG0571	ribonuclease III activity
AN946_RS06740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AN946_RS06760	COG1132	(ABC) transporter
AN946_RS06765	COG1132	(ABC) transporter
AN946_RS06775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AN946_RS06780	COG4988	ABC transporter
AN946_RS06785	COG1294	oxidase, subunit
AN946_RS06790	COG1271	oxidase subunit
AN946_RS06795	COG1530	ribonuclease E activity
AN946_RS06800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AN946_RS06810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AN946_RS06820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AN946_RS06825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AN946_RS06835	COG0799	negative regulation of ribosome biogenesis
AN946_RS06840	COG0406	alpha-ribazole phosphatase activity
AN946_RS06875	COG0235	Class ii aldolase
AN946_RS06880	COG0738	Major facilitator superfamily
AN946_RS06890	COG1609	Transcriptional regulator
AN946_RS06895	COG0133	tryptophan synthase activity
AN946_RS06900	COG0726	polysaccharide deacetylase
AN946_RS06940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN946_RS06955	COG0826	peptidase U32
AN946_RS06960	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AN946_RS06970	COG1113	amino acid transport
AN946_RS06975	COG1464	Belongs to the NlpA lipoprotein family
AN946_RS06980	COG2011	ABC-type metal ion transport system permease component
AN946_RS06990	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AN946_RS06990	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AN946_RS06995	COG1113	amino acid transport
AN946_RS07005	COG1395	domain, Protein
AN946_RS07015	COG0671	phosphoesterase, PA-phosphatase related
AN946_RS07030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN946_RS07035	COG1121	(ABC) transporter
AN946_RS07045	COG0803	Belongs to the bacterial solute-binding protein 9 family
AN946_RS07065	COG1435	thymidine kinase activity
AN946_RS07075	COG0813	purine-nucleoside phosphorylase activity
AN946_RS07100	COG0495	leucyl-tRNA aminoacylation
AN946_RS07115	COG0433	COG0433 Predicted ATPase
AN946_RS07135	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AN946_RS07140	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AN946_RS07145	COG0268	Binds directly to 16S ribosomal RNA
AN946_RS07170	COG0481	GTPase activity
AN946_RS07175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AN946_RS07195	COG1420	regulation of RNA biosynthetic process
AN946_RS07200	COG0484	heat shock protein binding
AN946_RS07205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AN946_RS07215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AN946_RS07250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN946_RS07255	COG1381	Involved in DNA repair and RecF pathway recombination
AN946_RS07260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN946_RS07265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AN946_RS07275	COG0131	Imidazoleglycerol-phosphate dehydratase
AN946_RS07285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AN946_RS07290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AN946_RS07300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AN946_RS07305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AN946_RS07320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN946_RS07340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AN946_RS07345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AN946_RS07360	COG1438	arginine binding
AN946_RS07365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AN946_RS07375	COG1476	TRANSCRIPTIONal
AN946_RS07385	COG1131	(ABC) transporter
AN946_RS07390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN946_RS07395	COG0803	Belongs to the bacterial solute-binding protein 9 family
AN946_RS07400	COG1121	(ABC) transporter
AN946_RS07405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN946_RS07410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN946_RS07440	COG0647	UMP catabolic process
AN946_RS07450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AN946_RS07455	COG0497	DNA recombination
AN946_RS07475	COG0728	peptidoglycan biosynthetic process
AN946_RS07505	COG0396	ATPase activity
AN946_RS07520	COG2151	metal-sulfur cluster biosynthetic enzyme
AN946_RS07525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN946_RS07530	COG0488	(ABC) transporter
AN946_RS07540	COG3830	Belongs to the UPF0237 family
AN946_RS07540	COG0560	Phosphoserine phosphatase
AN946_RS07555	COG0297	glycogen (starch) synthase activity
AN946_RS07560	COG1119	ATPase activity
AN946_RS07595	COG1881	PFAM PEBP family protein
AN946_RS07610	COG0587	DNA-directed DNA polymerase activity
AN946_RS07635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN946_RS07635	COG0519	Catalyzes the synthesis of GMP from XMP
AN946_RS07645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN946_RS07660	COG1968	undecaprenyl-diphosphatase activity
AN946_RS07680	COG1222	aaa ATPase
AN946_RS07685	COG4122	O-methyltransferase activity
AN946_RS07695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AN946_RS07710	COG0107	imidazoleglycerol-phosphate synthase activity
AN946_RS07720	COG0134	indole-3-glycerol-phosphate synthase activity
AN946_RS07725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AN946_RS07730	COG0469	pyruvate kinase activity
AN946_RS07755	COG0539	negative regulation of cytoplasmic translation
AN946_RS07780	COG1136	(ABC) transporter
AN946_RS07785	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AN946_RS07790	COG0237	dephospho-CoA kinase activity
AN946_RS07795	COG0556	nucleotide-excision repair
AN946_RS07820	COG0322	excinuclease ABC activity
AN946_RS07825	COG1660	Displays ATPase and GTPase activities
AN946_RS07835	COG1481	regulation of sporulation
AN946_RS07840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN946_RS07845	COG0126	phosphoglycerate kinase activity
AN946_RS07850	COG0149	triose-phosphate isomerase activity
AN946_RS07855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AN946_RS07870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN946_RS07895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AN946_RS07910	COG1160	GTP binding
AN946_RS07915	COG0205	6-phosphofructokinase activity
AN946_RS07960	COG1216	Glycosyl transferase, family 2
AN946_RS07970	COG4581	dead DEAH box helicase
AN946_RS08000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AN946_RS08005	COG0140	phosphoribosyl-ATP diphosphatase activity
AN946_RS08010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AN946_RS08015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AN946_RS08020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AN946_RS08030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AN946_RS08035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AN946_RS08040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AN946_RS08050	COG1758	RNA polymerase activity
AN946_RS08055	COG0194	GDP metabolic process
AN946_RS08070	COG0505	Belongs to the CarA family
AN946_RS08075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AN946_RS08080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AN946_RS08085	COG2217	Heavy metal translocating P-type atpase
AN946_RS08090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AN946_RS08100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AN946_RS08120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AN946_RS08125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AN946_RS08135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AN946_RS08145	COG2409	Drug exporters of the RND superfamily
AN946_RS08160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AN946_RS08180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AN946_RS08185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AN946_RS08190	COG0124	histidyl-tRNA synthetase
AN946_RS08195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN946_RS08200	COG1196	nuclear chromosome segregation
AN946_RS08220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN946_RS08225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AN946_RS08230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN946_RS08235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN946_RS08245	COG2255	four-way junction helicase activity
AN946_RS08250	COG0632	four-way junction helicase activity
AN946_RS08255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AN946_RS08260	COG0217	transcriptional regulatory protein
AN946_RS08265	COG1051	belongs to the nudix hydrolase family
AN946_RS08275	COG0438	transferase activity, transferring glycosyl groups
AN946_RS08285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AN946_RS08290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AN946_RS08295	COG1760	l-serine dehydratase
AN946_RS08300	COG2197	response regulator
AN946_RS08325	COG4412	M6 family metalloprotease domain protein
AN946_RS08325	COG1404	Belongs to the peptidase S8 family
AN946_RS08375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AN946_RS08385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AN946_RS08400	COG0569	domain protein
AN946_RS08445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AN946_RS08460	COG0187	DNA topoisomerase II activity
AN946_RS08470	COG1199	ATP-dependent helicase activity
AN946_RS08470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN946_RS08475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AN946_RS08490	COG0142	geranyltranstransferase activity
AN946_RS08505	COG2815	serine threonine protein kinase
AN946_RS08505	COG0515	serine threonine protein kinase
AN946_RS08510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AN946_RS08515	COG0205	6-phosphofructokinase activity
AN946_RS08555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN946_RS08570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN946_RS08580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN946_RS08585	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN946_RS08605	COG0174	glutamine synthetase
AN946_RS08615	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AN946_RS08620	COG0174	glutamine synthetase
AN946_RS08635	COG1940	carbohydrate kinase activity
AN946_RS08640	COG3022	response to hydroperoxide
AN946_RS08650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AN946_RS08655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AN946_RS08660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AN946_RS08685	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AN946_RS08705	COG0009	L-threonylcarbamoyladenylate synthase
AN946_RS08725	COG1090	epimerase
AN946_RS08760	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AN946_RS08765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN946_RS08800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN946_RS08805	COG0805	protein transport
AN946_RS08815	COG0358	DNA primase activity
AN946_RS08840	COG0423	glycine-tRNA ligase activity
AN946_RS08850	COG1121	(ABC) transporter
AN946_RS08855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN946_RS08860	COG0735	belongs to the Fur family
AN946_RS08875	COG0587	DNA-directed DNA polymerase activity
AN946_RS08890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AN946_RS08905	COG1799	cell septum assembly
AN946_RS08915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AN946_RS08925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN946_RS08930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AN946_RS08935	COG0772	Belongs to the SEDS family
AN946_RS08940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AN946_RS08945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AN946_RS08950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AN946_RS08955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AN946_RS08960	COG0768	penicillin binding
AN946_RS08970	COG0275	rRNA processing
AN946_RS08975	COG2001	Belongs to the MraZ family
AN946_RS08985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AN946_RS09005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN946_RS09010	COG0318	PFAM AMP-dependent synthetase and ligase
AN946_RS09015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AN946_RS09025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AN946_RS09035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AN946_RS09045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AN946_RS09050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN946_RS09055	COG2137	regulation of response to DNA damage stimulus
AN946_RS09060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AN946_RS09070	COG1396	sequence-specific DNA binding
AN946_RS09075	COG1546	Belongs to the CinA family
AN946_RS09075	COG1058	Belongs to the CinA family
AN946_RS09090	COG1674	ftsk spoiiie
AN946_RS09095	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AN946_RS09110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AN946_RS09115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AN946_RS09120	COG0612	Peptidase, M16
AN946_RS09130	COG1185	polyribonucleotide nucleotidyltransferase activity
AN946_RS09175	COG3842	ATPase activity
AN946_RS09185	COG2271	Major facilitator Superfamily
AN946_RS09190	COG0745	RESPONSE REGULATOR receiver
AN946_RS09195	COG3852	Histidine kinase
AN946_RS09200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AN946_RS09205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AN946_RS09210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AN946_RS09220	COG0779	Required for maturation of 30S ribosomal subunits
AN946_RS09230	COG0442	prolyl-tRNA aminoacylation
AN946_RS09240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AN946_RS09245	COG0750	zinc metalloprotease
AN946_RS09250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AN946_RS09260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AN946_RS09270	COG0233	cytoplasmic translational termination
AN946_RS09295	COG0644	oxidoreductase
AN946_RS09300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AN946_RS09310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AN946_RS09315	COG0052	Belongs to the universal ribosomal protein uS2 family
AN946_RS09320	COG2860	membrane
AN946_RS09325	COG1388	LysM domain
AN946_RS09325	COG4942	peptidase
AN946_RS09330	COG4974	Belongs to the 'phage' integrase family
AN946_RS09355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AN946_RS09360	COG0681	Belongs to the peptidase S26 family
AN946_RS09365	COG0335	large ribosomal subunit rRNA binding
AN946_RS09375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AN946_RS09380	COG1837	Belongs to the UPF0109 family
AN946_RS09385	COG0228	four-way junction DNA binding
AN946_RS09390	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AN946_RS09430	COG0105	UTP biosynthetic process
AN946_RS09435	COG0285	dihydrofolate synthase activity
AN946_RS09440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AN946_RS09455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AN946_RS09475	COG0287	Prephenate dehydrogenase
AN946_RS09475	COG1605	Chorismate mutase
AN946_RS09480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AN946_RS09485	COG0740	serine-type endopeptidase activity
AN946_RS09490	COG0740	serine-type endopeptidase activity
AN946_RS09495	COG0544	peptidyl-prolyl cis-trans isomerase activity
AN946_RS09500	COG0667	Aldo Keto reductase
AN946_RS09520	COG3250	beta-galactosidase activity
AN946_RS09525	COG1609	Transcriptional regulator
AN946_RS09535	COG0488	(ABC) transporter
AN946_RS09560	COG4824	toxin secretion phage lysis holin
AN946_RS09640	COG4695	Portal protein
AN946_RS09650	COG1802	Transcriptional regulator
AN946_RS09650	COG4626	Terminase
AN946_RS09680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AN946_RS09720	COG3617	BRO family, N-terminal domain
AN946_RS09730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN946_RS09730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN946_RS09790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AN946_RS09820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN946_RS09835	COG1739	Uncharacterized protein family UPF0029
AN946_RS09845	COG1045	serine acetyltransferase
AN946_RS09860	COG3590	peptidase
AN946_RS09865	COG2354	Protein conserved in bacteria
AN946_RS09875	COG0519	Catalyzes the synthesis of GMP from XMP
AN946_RS09890	COG1946	Acyl-CoA thioesterase
AN946_RS09920	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AN946_RS10035	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AN946_RS10050	COG0463	Glycosyl transferase, family 2
AN946_RS10055	COG2244	polysaccharide biosynthetic process
AN946_RS10080	COG1442	glycosyl transferase family 8
AN946_RS10080	COG1216	Glycosyl transferase, family 2
AN946_RS10085	COG3475	LICD family
AN946_RS10090	COG4750	Nucleotidyl transferase
AN946_RS10095	COG0438	transferase activity, transferring glycosyl groups
AN946_RS10125	COG1882	Formate acetyltransferase
AN946_RS10130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AN946_RS10145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AN946_RS10150	COG0440	acetolactate synthase activity
AN946_RS10160	COG2985	domain, Protein
AN946_RS10160	COG0569	domain protein
AN946_RS10165	COG0129	dihydroxy-acid dehydratase activity