locus-tag	class	description
M5C92_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M5C92_RS00010	COG0592	DNA-directed DNA polymerase activity
M5C92_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M5C92_RS00025	COG0187	DNA topoisomerase II activity
M5C92_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5C92_RS00075	COG0457	Tetratricopeptide repeat
M5C92_RS00075	COG0705	Rhomboid family
M5C92_RS00085	COG3764	Sortase (surface protein transpeptidase)
M5C92_RS00115	COG1716	ATPase activity
M5C92_RS00120	COG1716	ATPase activity
M5C92_RS00120	COG1131	(ABC) transporter
M5C92_RS00120	COG0842	Transport permease protein
M5C92_RS00150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M5C92_RS00155	COG1854	S-ribosylhomocysteine lyase activity
M5C92_RS00170	COG1780	Probably involved in ribonucleotide reductase function
M5C92_RS00175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5C92_RS00180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M5C92_RS00190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5C92_RS00195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5C92_RS00210	COG0395	ABC-type sugar transport system, permease component
M5C92_RS00215	COG1175	transmembrane transport
M5C92_RS00235	COG2072	flavoprotein involved in K transport
M5C92_RS00245	COG1643	Atp-dependent helicase
M5C92_RS00250	COG2197	response regulator
M5C92_RS00255	COG4585	Histidine kinase
M5C92_RS00265	COG1131	(ABC) transporter
M5C92_RS00275	COG1136	(ABC) transporter
M5C92_RS00285	COG2197	response regulator
M5C92_RS00295	COG1328	CTP reductase activity
M5C92_RS00315	COG1136	(ABC) transporter
M5C92_RS00315	COG0577	efflux transmembrane transporter activity
M5C92_RS00320	COG1414	Transcriptional regulator
M5C92_RS00325	COG0246	Mannitol dehydrogenase
M5C92_RS00330	COG1312	Catalyzes the dehydration of D-mannonate
M5C92_RS00335	COG0800	Aldolase
M5C92_RS00340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5C92_RS00345	COG2226	methyltransferase
M5C92_RS00355	COG1120	ATPase activity
M5C92_RS00365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5C92_RS00380	COG1132	(ABC) transporter
M5C92_RS00385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M5C92_RS00390	COG1609	Transcriptional regulator
M5C92_RS00405	COG1175	transmembrane transport
M5C92_RS00410	COG0395	ABC-type sugar transport system, permease component
M5C92_RS00435	COG1487	ribonuclease activity
M5C92_RS00450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M5C92_RS00480	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5C92_RS00485	COG1879	ABC-type sugar transport system periplasmic component
M5C92_RS00490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M5C92_RS00490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M5C92_RS00495	COG1486	melibiose metabolic process
M5C92_RS00520	COG0561	phosphatase activity
M5C92_RS00525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M5C92_RS00540	COG0077	Prephenate dehydratase
M5C92_RS00565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M5C92_RS00585	COG4868	Belongs to the UPF0371 family
M5C92_RS00590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M5C92_RS00640	COG0521	Mo-molybdopterin cofactor biosynthetic process
M5C92_RS00650	COG0315	cyclic pyranopterin monophosphate synthase activity
M5C92_RS00660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M5C92_RS00685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5C92_RS00720	COG2267	carboxylic ester hydrolase activity
M5C92_RS00770	COG3655	Transcriptional regulator
M5C92_RS00780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M5C92_RS00780	COG2890	protein-(glutamine-N5) methyltransferase activity
M5C92_RS00785	COG1754	DNA topoisomerase type I activity
M5C92_RS00785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5C92_RS00790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M5C92_RS00795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M5C92_RS00890	COG2184	nucleotidyltransferase activity
M5C92_RS00915	COG1192	Involved in chromosome partitioning
M5C92_RS00925	COG4974	Belongs to the 'phage' integrase family
M5C92_RS00975	COG0717	Belongs to the dCTP deaminase family
M5C92_RS00980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M5C92_RS00980	COG2111	Na H antiporter
M5C92_RS00985	COG1006	Multisubunit Na H antiporter MnhC subunit
M5C92_RS00990	COG0651	ATP synthesis coupled electron transport
M5C92_RS01020	COG4149	molybdate abc transporter
M5C92_RS01025	COG3842	ATPase activity
M5C92_RS01040	COG0662	Cupin 2, conserved barrel domain protein
M5C92_RS01085	COG1940	carbohydrate kinase activity
M5C92_RS01090	COG0390	transport system, permease component
M5C92_RS01100	COG1505	serine-type exopeptidase activity
M5C92_RS01110	COG0437	4 iron, 4 sulfur cluster binding
M5C92_RS01115	COG0243	molybdopterin cofactor binding
M5C92_RS01120	COG1937	Protein conserved in bacteria
M5C92_RS01125	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5C92_RS01135	COG0437	4 iron, 4 sulfur cluster binding
M5C92_RS01140	COG0243	molybdopterin cofactor binding
M5C92_RS01150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M5C92_RS01155	COG0540	Belongs to the ATCase OTCase family
M5C92_RS01160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M5C92_RS01165	COG0284	orotidine-5'-phosphate decarboxylase activity
M5C92_RS01170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M5C92_RS01175	COG0167	dihydroorotate dehydrogenase activity
M5C92_RS01180	COG0443	Heat shock 70 kDa protein
M5C92_RS01185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M5C92_RS01190	COG0484	heat shock protein binding
M5C92_RS01215	COG0584	glycerophosphoryl diester phosphodiesterase
M5C92_RS01225	COG1506	peptidase
M5C92_RS01225	COG0823	Involved in the tonB-independent uptake of proteins
M5C92_RS01235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5C92_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
M5C92_RS01280	COG0494	nUDIX hydrolase
M5C92_RS01295	COG0191	fructose-bisphosphate aldolase activity
M5C92_RS01305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M5C92_RS01310	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
M5C92_RS01315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M5C92_RS01320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5C92_RS01350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5C92_RS01380	COG0039	L-malate dehydrogenase activity
M5C92_RS01385	COG0728	peptidoglycan biosynthetic process
M5C92_RS01410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5C92_RS01435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M5C92_RS01440	COG0494	nUDIX hydrolase
M5C92_RS01440	COG0406	alpha-ribazole phosphatase activity
M5C92_RS01460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5C92_RS01465	COG0306	phosphate transporter
M5C92_RS01475	COG1115	amino acid carrier protein
M5C92_RS01485	COG0737	Belongs to the 5'-nucleotidase family
M5C92_RS01495	COG3485	protocatechuate 3,4-dioxygenase
M5C92_RS01500	COG0354	folic acid binding
M5C92_RS01510	COG1490	D-aminoacyl-tRNA deacylase activity
M5C92_RS01530	COG0738	Major facilitator superfamily
M5C92_RS01535	COG2390	Transcriptional regulator
M5C92_RS01555	COG1349	DNA-binding transcription factor activity
M5C92_RS01575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M5C92_RS01580	COG2376	Dihydroxyacetone kinase
M5C92_RS01590	COG0698	ribose 5-phosphate isomerase
M5C92_RS01595	COG0730	response to heat
M5C92_RS01600	COG0641	radical SAM
M5C92_RS01605	COG2814	Major facilitator Superfamily
M5C92_RS01610	COG1609	Transcriptional regulator
M5C92_RS01615	COG3119	arylsulfatase activity
M5C92_RS01625	COG0395	ABC-type sugar transport system, permease component
M5C92_RS01640	COG1501	Belongs to the glycosyl hydrolase 31 family
M5C92_RS01650	COG1349	DNA-binding transcription factor activity
M5C92_RS01660	COG1175	transmembrane transport
M5C92_RS01665	COG0395	ABC-type sugar transport system, permease component
M5C92_RS01690	COG2115	Belongs to the xylose isomerase family
M5C92_RS01695	COG1070	Carbohydrate kinase
M5C92_RS01700	COG4213	ABC transporter substrate-binding protein
M5C92_RS01710	COG4214	carbohydrate transport
M5C92_RS01715	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M5C92_RS01720	COG1757	Na H antiporter
M5C92_RS01730	COG3250	beta-galactosidase activity
M5C92_RS01740	COG0395	ABC-type sugar transport system, permease component
M5C92_RS01750	COG1609	Transcriptional regulator
M5C92_RS01760	COG0395	ABC-type sugar transport system, permease component
M5C92_RS01765	COG1175	transmembrane transport
M5C92_RS01780	COG3250	beta-galactosidase activity
M5C92_RS01790	COG1609	Transcriptional regulator
M5C92_RS01800	COG2610	gluconate transmembrane transporter activity
M5C92_RS01820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M5C92_RS01825	COG3250	beta-galactosidase activity
M5C92_RS01830	COG1869	D-ribose catabolic process
M5C92_RS01840	COG1879	ABC-type sugar transport system periplasmic component
M5C92_RS01845	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5C92_RS01850	COG1129	ABC transporter
M5C92_RS01855	COG1609	Transcriptional regulator
M5C92_RS01860	COG2226	methyltransferase
M5C92_RS01865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5C92_RS01865	COG1116	anion transmembrane transporter activity
M5C92_RS01885	COG0737	Belongs to the 5'-nucleotidase family
M5C92_RS01895	COG1609	Transcriptional regulator
M5C92_RS01900	COG2271	Major facilitator Superfamily
M5C92_RS01905	COG1285	pathogenesis
M5C92_RS01925	COG3177	Filamentation induced by cAMP protein fic
M5C92_RS01930	COG1715	Restriction endonuclease
M5C92_RS01935	COG5290	Psort location Cytoplasmic, score
M5C92_RS01955	COG0366	Alpha amylase catalytic
M5C92_RS01960	COG0395	ABC-type sugar transport system, permease component
M5C92_RS01965	COG1175	transmembrane transport
M5C92_RS01980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5C92_RS01980	COG0574	Belongs to the PEP-utilizing enzyme family
M5C92_RS01985	COG0247	lactate metabolic process
M5C92_RS01985	COG0277	FAD linked oxidase domain protein
M5C92_RS01995	COG2267	carboxylic ester hydrolase activity
M5C92_RS02000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M5C92_RS02005	COG0791	NLP P60 protein
M5C92_RS02010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M5C92_RS02025	COG0037	tRNA processing
M5C92_RS02035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5C92_RS02040	COG0302	gtp cyclohydrolase
M5C92_RS02050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5C92_RS02070	COG1609	Transcriptional regulator
M5C92_RS02090	COG3250	beta-galactosidase activity
M5C92_RS02100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5C92_RS02100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5C92_RS02105	COG1461	Dihydroxyacetone kinase
M5C92_RS02110	COG2376	Dihydroxyacetone kinase
M5C92_RS02120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M5C92_RS02125	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M5C92_RS02135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M5C92_RS02140	COG2409	Drug exporters of the RND superfamily
M5C92_RS02145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M5C92_RS02150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5C92_RS02160	COG3386	PFAM SMP-30 Gluconolaconase
M5C92_RS02165	COG0247	lactate metabolic process
M5C92_RS02170	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
M5C92_RS02175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M5C92_RS02190	COG1194	a g-specific adenine glycosylase
M5C92_RS02200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M5C92_RS02205	COG0569	domain protein
M5C92_RS02210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5C92_RS02225	COG1846	Transcriptional regulator
M5C92_RS02230	COG0406	alpha-ribazole phosphatase activity
M5C92_RS02255	COG0395	ABC-type sugar transport system, permease component
M5C92_RS02260	COG1175	transmembrane transport
M5C92_RS02270	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M5C92_RS02275	COG4948	Mandelate Racemase Muconate Lactonizing
M5C92_RS02280	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M5C92_RS02285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5C92_RS02290	COG1169	isochorismate synthase
M5C92_RS02295	COG2226	methyltransferase
M5C92_RS02300	COG0644	oxidoreductase
M5C92_RS02310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M5C92_RS02315	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M5C92_RS02320	COG0649	NAD binding
M5C92_RS02330	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M5C92_RS02335	COG1034	ATP synthesis coupled electron transport
M5C92_RS02340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M5C92_RS02345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M5C92_RS02350	COG0839	Belongs to the complex I subunit 6 family
M5C92_RS02355	COG0713	ATP synthesis coupled electron transport
M5C92_RS02370	COG1007	ATP synthesis coupled electron transport
M5C92_RS02375	COG0142	geranyltranstransferase activity
M5C92_RS02380	COG0653	protein targeting
M5C92_RS02420	COG0419	ATPase involved in DNA repair
M5C92_RS02425	COG0420	3'-5' exonuclease activity
M5C92_RS02430	COG0483	inositol monophosphate 1-phosphatase activity
M5C92_RS02435	COG1162	GTPase activity
M5C92_RS02440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M5C92_RS02465	COG0657	acetylesterase activity
M5C92_RS02480	COG0601	transmembrane transport
M5C92_RS02485	COG0444	Belongs to the ABC transporter superfamily
M5C92_RS02490	COG4608	Belongs to the ABC transporter superfamily
M5C92_RS02495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5C92_RS02505	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M5C92_RS02510	COG0363	glucosamine-6-phosphate deaminase activity
M5C92_RS02520	COG1595	DNA-templated transcription, initiation
M5C92_RS02535	COG0791	NLP P60 protein
M5C92_RS02535	COG1388	LysM domain
M5C92_RS02535	COG3103	Sh3 type 3 domain protein
M5C92_RS02545	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5C92_RS02545	COG0567	Dehydrogenase, E1 component
M5C92_RS02550	COG1253	flavin adenine dinucleotide binding
M5C92_RS02560	COG0739	heme binding
M5C92_RS02565	COG0584	glycerophosphoryl diester phosphodiesterase
M5C92_RS02605	COG0018	arginyl-trna synthetase
M5C92_RS02615	COG0460	homoserine dehydrogenase
M5C92_RS02620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M5C92_RS02625	COG0083	homoserine kinase activity
M5C92_RS02640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M5C92_RS02665	COG0356	it plays a direct role in the translocation of protons across the membrane
M5C92_RS02670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M5C92_RS02675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M5C92_RS02680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M5C92_RS02685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M5C92_RS02690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M5C92_RS02695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M5C92_RS02700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M5C92_RS02710	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
M5C92_RS02755	COG1609	Transcriptional regulator
M5C92_RS02765	COG1175	transmembrane transport
M5C92_RS02770	COG3833	ABC-type maltose transport systems, permease component
M5C92_RS02780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M5C92_RS02785	COG3281	Trehalose synthase
M5C92_RS02790	COG0366	Alpha amylase catalytic
M5C92_RS02795	COG0366	Alpha amylase catalytic
M5C92_RS02825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5C92_RS02830	COG0058	SHG alpha-glucan phosphorylase activity
M5C92_RS02835	COG0180	Tryptophanyl-tRNA synthetase
M5C92_RS02865	COG3480	Lon protease (S16) C-terminal proteolytic domain
M5C92_RS02875	COG1615	UPF0182 protein
M5C92_RS02880	COG1470	cell adhesion involved in biofilm formation
M5C92_RS02880	COG0366	Alpha amylase catalytic
M5C92_RS02900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5C92_RS02905	COG1131	(ABC) transporter
M5C92_RS02915	COG0387	Pfam Sodium calcium exchanger
M5C92_RS02925	COG1053	succinate dehydrogenase
M5C92_RS02950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M5C92_RS02985	COG4585	Histidine kinase
M5C92_RS02990	COG2135	peptidase activity
M5C92_RS02995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M5C92_RS03005	COG1397	ADP-ribosylglycohydrolase
M5C92_RS03015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5C92_RS03020	COG3177	Filamentation induced by cAMP protein fic
M5C92_RS03030	COG1404	Belongs to the peptidase S8 family
M5C92_RS03040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5C92_RS03045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5C92_RS03050	COG0154	amidase activity
M5C92_RS03055	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5C92_RS03105	COG0129	dihydroxy-acid dehydratase activity
M5C92_RS03110	COG2985	domain, Protein
M5C92_RS03110	COG0569	domain protein
M5C92_RS03120	COG0440	acetolactate synthase activity
M5C92_RS03125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M5C92_RS03145	COG0473	3-isopropylmalate dehydrogenase activity
M5C92_RS03150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5C92_RS03155	COG1882	Formate acetyltransferase
M5C92_RS03185	COG0438	transferase activity, transferring glycosyl groups
M5C92_RS03190	COG4750	Nucleotidyl transferase
M5C92_RS03195	COG3475	LICD family
M5C92_RS03200	COG1215	transferase activity, transferring glycosyl groups
M5C92_RS03225	COG2244	polysaccharide biosynthetic process
M5C92_RS03230	COG0463	Glycosyl transferase, family 2
M5C92_RS03260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M5C92_RS03290	COG1946	Acyl-CoA thioesterase
M5C92_RS03305	COG0519	Catalyzes the synthesis of GMP from XMP
M5C92_RS03315	COG2354	Protein conserved in bacteria
M5C92_RS03320	COG3590	peptidase
M5C92_RS03330	COG1045	serine acetyltransferase
M5C92_RS03340	COG1739	Uncharacterized protein family UPF0029
M5C92_RS03355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5C92_RS03385	COG1609	Transcriptional regulator
M5C92_RS03390	COG3250	beta-galactosidase activity
M5C92_RS03410	COG0667	Aldo Keto reductase
M5C92_RS03415	COG0544	peptidyl-prolyl cis-trans isomerase activity
M5C92_RS03420	COG0740	serine-type endopeptidase activity
M5C92_RS03425	COG0740	serine-type endopeptidase activity
M5C92_RS03430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M5C92_RS03435	COG1605	Chorismate mutase
M5C92_RS03435	COG0287	Prephenate dehydrogenase
M5C92_RS03455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5C92_RS03470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5C92_RS03475	COG0285	dihydrofolate synthase activity
M5C92_RS03480	COG0105	UTP biosynthetic process
M5C92_RS03525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M5C92_RS03530	COG0228	four-way junction DNA binding
M5C92_RS03535	COG1837	Belongs to the UPF0109 family
M5C92_RS03540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M5C92_RS03550	COG0335	large ribosomal subunit rRNA binding
M5C92_RS03555	COG0681	Belongs to the peptidase S26 family
M5C92_RS03560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5C92_RS03585	COG4974	Belongs to the 'phage' integrase family
M5C92_RS03590	COG1388	LysM domain
M5C92_RS03590	COG4942	peptidase
M5C92_RS03595	COG2860	membrane
M5C92_RS03600	COG0052	Belongs to the universal ribosomal protein uS2 family
M5C92_RS03605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M5C92_RS03615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M5C92_RS03620	COG0644	oxidoreductase
M5C92_RS03645	COG0233	cytoplasmic translational termination
M5C92_RS03650	COG0575	Belongs to the CDS family
M5C92_RS03655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M5C92_RS03665	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M5C92_RS03670	COG0750	zinc metalloprotease
M5C92_RS03675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M5C92_RS03685	COG0442	prolyl-tRNA aminoacylation
M5C92_RS03695	COG0779	Required for maturation of 30S ribosomal subunits
M5C92_RS03710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M5C92_RS03715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M5C92_RS03720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M5C92_RS03725	COG3852	Histidine kinase
M5C92_RS03730	COG0745	RESPONSE REGULATOR receiver
M5C92_RS03735	COG2271	Major facilitator Superfamily
M5C92_RS03745	COG3842	ATPase activity
M5C92_RS03775	COG0842	Transport permease protein
M5C92_RS03775	COG1129	ABC transporter
M5C92_RS03790	COG1185	polyribonucleotide nucleotidyltransferase activity
M5C92_RS03800	COG0612	Peptidase, M16
M5C92_RS03805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M5C92_RS03810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5C92_RS03825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M5C92_RS03830	COG1674	ftsk spoiiie
M5C92_RS03845	COG1546	Belongs to the CinA family
M5C92_RS03845	COG1058	Belongs to the CinA family
M5C92_RS03850	COG1396	sequence-specific DNA binding
M5C92_RS03860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M5C92_RS03865	COG2137	regulation of response to DNA damage stimulus
M5C92_RS03870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5C92_RS03875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M5C92_RS03885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M5C92_RS03895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M5C92_RS03905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M5C92_RS03910	COG0318	PFAM AMP-dependent synthetase and ligase
M5C92_RS03915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5C92_RS03935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5C92_RS03945	COG2001	Belongs to the MraZ family
M5C92_RS03950	COG0275	rRNA processing
M5C92_RS03960	COG0768	penicillin binding
M5C92_RS03965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M5C92_RS03970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M5C92_RS03975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5C92_RS03980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M5C92_RS03985	COG0772	Belongs to the SEDS family
M5C92_RS03990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M5C92_RS03995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5C92_RS04005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M5C92_RS04015	COG1799	cell septum assembly
M5C92_RS04030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M5C92_RS04045	COG0587	DNA-directed DNA polymerase activity
M5C92_RS04060	COG0735	belongs to the Fur family
M5C92_RS04065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5C92_RS04070	COG1121	(ABC) transporter
M5C92_RS04080	COG0423	glycine-tRNA ligase activity
M5C92_RS04105	COG0358	DNA primase activity
M5C92_RS04115	COG0805	protein transport
M5C92_RS04120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M5C92_RS04155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5C92_RS04160	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M5C92_RS04200	COG1090	epimerase
M5C92_RS04220	COG0009	L-threonylcarbamoyladenylate synthase
M5C92_RS04240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M5C92_RS04265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5C92_RS04270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5C92_RS04275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5C92_RS04295	COG1940	carbohydrate kinase activity
M5C92_RS04310	COG0174	glutamine synthetase
M5C92_RS04315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M5C92_RS04325	COG0174	glutamine synthetase
M5C92_RS04345	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5C92_RS04350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5C92_RS04360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M5C92_RS04375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5C92_RS04415	COG0205	6-phosphofructokinase activity
M5C92_RS04420	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M5C92_RS04425	COG2815	serine threonine protein kinase
M5C92_RS04425	COG0515	serine threonine protein kinase
M5C92_RS04440	COG0142	geranyltranstransferase activity
M5C92_RS04455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M5C92_RS04460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5C92_RS04460	COG1199	ATP-dependent helicase activity
M5C92_RS04470	COG0187	DNA topoisomerase II activity
M5C92_RS04485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5C92_RS04525	COG0569	domain protein
M5C92_RS04540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M5C92_RS04550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M5C92_RS04615	COG2197	response regulator
M5C92_RS04620	COG1760	l-serine dehydratase
M5C92_RS04625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M5C92_RS04630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5C92_RS04640	COG0438	transferase activity, transferring glycosyl groups
M5C92_RS04650	COG1051	belongs to the nudix hydrolase family
M5C92_RS04655	COG0217	transcriptional regulatory protein
M5C92_RS04660	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M5C92_RS04665	COG0632	four-way junction helicase activity
M5C92_RS04670	COG2255	four-way junction helicase activity
M5C92_RS04680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5C92_RS04685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5C92_RS04690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5C92_RS04695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5C92_RS04705	COG1196	nuclear chromosome segregation
M5C92_RS04710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5C92_RS04715	COG0124	histidyl-tRNA synthetase
M5C92_RS04720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M5C92_RS04725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M5C92_RS04745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M5C92_RS04760	COG2409	Drug exporters of the RND superfamily
M5C92_RS04770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M5C92_RS04780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M5C92_RS04785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M5C92_RS04805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M5C92_RS04815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M5C92_RS04820	COG2217	Heavy metal translocating P-type atpase
M5C92_RS04825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M5C92_RS04830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5C92_RS04835	COG0505	Belongs to the CarA family
M5C92_RS04840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5C92_RS04850	COG0194	GDP metabolic process
M5C92_RS04855	COG1758	RNA polymerase activity
M5C92_RS04865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M5C92_RS04870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M5C92_RS04875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M5C92_RS04885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5C92_RS04890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5C92_RS04895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5C92_RS04900	COG0140	phosphoribosyl-ATP diphosphatase activity
M5C92_RS04905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M5C92_RS04935	COG4581	dead DEAH box helicase
M5C92_RS04945	COG1216	Glycosyl transferase, family 2
M5C92_RS04985	COG0205	6-phosphofructokinase activity
M5C92_RS04990	COG1160	GTP binding
M5C92_RS04995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M5C92_RS05010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M5C92_RS05035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5C92_RS05050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5C92_RS05055	COG0149	triose-phosphate isomerase activity
M5C92_RS05060	COG0126	phosphoglycerate kinase activity
M5C92_RS05065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5C92_RS05070	COG1481	regulation of sporulation
M5C92_RS05085	COG0322	excinuclease ABC activity
M5C92_RS05090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M5C92_RS05110	COG0556	nucleotide-excision repair
M5C92_RS05115	COG0237	dephospho-CoA kinase activity
M5C92_RS05120	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M5C92_RS05125	COG1136	(ABC) transporter
M5C92_RS05160	COG0469	pyruvate kinase activity
M5C92_RS05165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M5C92_RS05170	COG0134	indole-3-glycerol-phosphate synthase activity
M5C92_RS05180	COG0107	imidazoleglycerol-phosphate synthase activity
M5C92_RS05195	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M5C92_RS05205	COG4122	O-methyltransferase activity
M5C92_RS05210	COG1222	aaa ATPase
M5C92_RS05230	COG1968	undecaprenyl-diphosphatase activity
M5C92_RS05245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5C92_RS05255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M5C92_RS05255	COG0519	Catalyzes the synthesis of GMP from XMP
M5C92_RS05280	COG0587	DNA-directed DNA polymerase activity
M5C92_RS05295	COG1881	PFAM PEBP family protein
M5C92_RS05330	COG1119	ATPase activity
M5C92_RS05335	COG0297	glycogen (starch) synthase activity
M5C92_RS05345	COG1136	(ABC) transporter
M5C92_RS05355	COG0560	Phosphoserine phosphatase
M5C92_RS05355	COG3830	Belongs to the UPF0237 family
M5C92_RS05365	COG0488	(ABC) transporter
M5C92_RS05370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5C92_RS05375	COG2151	metal-sulfur cluster biosynthetic enzyme
M5C92_RS05390	COG0396	ATPase activity
M5C92_RS05420	COG0728	peptidoglycan biosynthetic process
M5C92_RS05440	COG0497	DNA recombination
M5C92_RS05445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5C92_RS05460	COG0647	UMP catabolic process
M5C92_RS05490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5C92_RS05495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5C92_RS05500	COG1121	(ABC) transporter
M5C92_RS05505	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5C92_RS05510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M5C92_RS05525	COG1476	TRANSCRIPTIONal
M5C92_RS05535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5C92_RS05540	COG1438	arginine binding
M5C92_RS05555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M5C92_RS05560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M5C92_RS05575	COG1902	pentaerythritol trinitrate reductase activity
M5C92_RS05580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5C92_RS05595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M5C92_RS05600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M5C92_RS05610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M5C92_RS05615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M5C92_RS05625	COG0131	Imidazoleglycerol-phosphate dehydratase
M5C92_RS05635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M5C92_RS05640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M5C92_RS05645	COG1381	Involved in DNA repair and RecF pathway recombination
M5C92_RS05650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5C92_RS05685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M5C92_RS05695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5C92_RS05700	COG0484	heat shock protein binding
M5C92_RS05705	COG1420	regulation of RNA biosynthetic process
M5C92_RS05725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M5C92_RS05730	COG0481	GTPase activity
M5C92_RS05755	COG0268	Binds directly to 16S ribosomal RNA
M5C92_RS05765	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M5C92_RS05770	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M5C92_RS05790	COG0433	COG0433 Predicted ATPase
M5C92_RS05805	COG0495	leucyl-tRNA aminoacylation
M5C92_RS05830	COG0813	purine-nucleoside phosphorylase activity
M5C92_RS05840	COG1435	thymidine kinase activity
M5C92_RS05860	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5C92_RS05870	COG1121	(ABC) transporter
M5C92_RS05875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5C92_RS05895	COG0671	phosphoesterase, PA-phosphatase related
M5C92_RS05915	COG1113	amino acid transport
M5C92_RS05920	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M5C92_RS05920	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M5C92_RS05930	COG2011	ABC-type metal ion transport system permease component
M5C92_RS05935	COG1464	Belongs to the NlpA lipoprotein family
M5C92_RS05940	COG1113	amino acid transport
M5C92_RS05950	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M5C92_RS05955	COG2186	Transcriptional regulator
M5C92_RS05960	COG0477	Major facilitator Superfamily
M5C92_RS05970	COG0826	peptidase U32
M5C92_RS05975	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M5C92_RS05980	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M5C92_RS05985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5C92_RS06025	COG0726	polysaccharide deacetylase
M5C92_RS06030	COG0133	tryptophan synthase activity
M5C92_RS06035	COG1609	Transcriptional regulator
M5C92_RS06045	COG0738	Major facilitator superfamily
M5C92_RS06050	COG0235	Class ii aldolase
M5C92_RS06105	COG0406	alpha-ribazole phosphatase activity
M5C92_RS06110	COG0799	negative regulation of ribosome biogenesis
M5C92_RS06120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M5C92_RS06125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5C92_RS06135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M5C92_RS06145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M5C92_RS06150	COG1530	ribonuclease E activity
M5C92_RS06155	COG1271	oxidase subunit
M5C92_RS06160	COG1294	oxidase, subunit
M5C92_RS06165	COG4988	ABC transporter
M5C92_RS06170	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M5C92_RS06180	COG1132	(ABC) transporter
M5C92_RS06185	COG1132	(ABC) transporter
M5C92_RS06205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M5C92_RS06210	COG0571	ribonuclease III activity
M5C92_RS06225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M5C92_RS06240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M5C92_RS06250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M5C92_RS06260	COG1181	Belongs to the D-alanine--D-alanine ligase family
M5C92_RS06265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5C92_RS06285	COG0438	transferase activity, transferring glycosyl groups
M5C92_RS06300	COG4975	Glucose uptake
M5C92_RS06305	COG0339	signal peptide processing
M5C92_RS06360	COG0179	Fumarylacetoacetate (FAA) hydrolase
M5C92_RS06370	COG1022	Amp-dependent synthetase and ligase
M5C92_RS06395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M5C92_RS06400	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M5C92_RS06410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M5C92_RS06420	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M5C92_RS06445	COG2985	domain, Protein
M5C92_RS06445	COG0569	domain protein
M5C92_RS06460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M5C92_RS06535	COG1846	Transcriptional regulator
M5C92_RS06540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M5C92_RS06590	COG2801	Transposase and inactivated derivatives
M5C92_RS06615	COG1122	ATPase activity
M5C92_RS06640	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5C92_RS06655	COG0739	heme binding
M5C92_RS06660	COG2177	Part of the ABC transporter FtsEX involved in
M5C92_RS06665	COG2884	Cell division ATP-binding protein ftsE
M5C92_RS06670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M5C92_RS06730	COG0513	Belongs to the DEAD box helicase family
M5C92_RS06735	COG2095	MarC family integral membrane protein
M5C92_RS06745	COG0006	proline dipeptidase activity
M5C92_RS06750	COG2239	Acts as a magnesium transporter
M5C92_RS06775	COG1611	Belongs to the LOG family
M5C92_RS06785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5C92_RS06790	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M5C92_RS06810	COG1079	Belongs to the binding-protein-dependent transport system permease family
M5C92_RS06815	COG4603	Belongs to the binding-protein-dependent transport system permease family
M5C92_RS06820	COG3845	ABC transporter
M5C92_RS06825	COG1744	ABC transporter substrate-binding protein PnrA-like
M5C92_RS06830	COG0662	Cupin 2, conserved barrel domain protein
M5C92_RS06830	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M5C92_RS06845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M5C92_RS06850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M5C92_RS06860	COG1268	BioY protein
M5C92_RS06870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M5C92_RS06875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5C92_RS06880	COG4770	biotin carboxylase activity
M5C92_RS06900	COG0644	oxidoreductase
M5C92_RS06905	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M5C92_RS06920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5C92_RS06925	COG2271	Major facilitator Superfamily
M5C92_RS06930	COG2030	dehydratase
M5C92_RS06970	COG0039	L-malate dehydrogenase activity
M5C92_RS06980	COG0166	Belongs to the GPI family
M5C92_RS06985	COG0205	6-phosphofructokinase activity
M5C92_RS07015	COG0045	succinate-CoA ligase (ADP-forming) activity
M5C92_RS07020	COG2755	lipolytic protein G-D-S-L family
M5C92_RS07020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M5C92_RS07035	COG0653	protein targeting
M5C92_RS07065	COG0542	response to heat
M5C92_RS07120	COG4974	Belongs to the 'phage' integrase family
M5C92_RS07145	COG0857	belongs to the CobB CobQ family
M5C92_RS07145	COG0280	phosphate acetyltransferase
M5C92_RS07150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M5C92_RS07165	COG1136	(ABC) transporter
M5C92_RS07175	COG0114	fumarate hydratase activity
M5C92_RS07180	COG0516	GMP reductase activity
M5C92_RS07205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5C92_RS07210	COG0151	Belongs to the GarS family
M5C92_RS07215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M5C92_RS07220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M5C92_RS07225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M5C92_RS07230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M5C92_RS07235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M5C92_RS07250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M5C92_RS07260	COG0428	transporter
M5C92_RS07265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M5C92_RS07270	COG0733	neurotransmitter:sodium symporter activity
M5C92_RS07280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5C92_RS07285	COG1053	succinate dehydrogenase
M5C92_RS07310	COG0802	atpase or kinase
M5C92_RS07315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5C92_RS07325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M5C92_RS07330	COG1072	(Pantothenic acid kinase))
M5C92_RS07340	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M5C92_RS07345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M5C92_RS07355	COG4720	Psort location CytoplasmicMembrane, score
M5C92_RS07360	COG1122	ATPase activity
M5C92_RS07380	COG0101	tRNA pseudouridine synthase activity
M5C92_RS07385	COG1940	carbohydrate kinase activity
M5C92_RS07395	COG0765	amino acid transport
M5C92_RS07405	COG0789	Transcriptional regulator
M5C92_RS07415	COG0203	ribosomal protein L17
M5C92_RS07420	COG0202	RNA polymerase activity
M5C92_RS07430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M5C92_RS07435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M5C92_RS07440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M5C92_RS07450	COG0563	adenylate kinase activity
M5C92_RS07460	COG0200	Binds to the 23S rRNA
M5C92_RS07465	COG1841	ribosomal large subunit assembly
M5C92_RS07470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M5C92_RS07480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M5C92_RS07485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M5C92_RS07490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M5C92_RS07495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M5C92_RS07500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M5C92_RS07505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M5C92_RS07520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M5C92_RS07525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M5C92_RS07530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M5C92_RS07535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M5C92_RS07540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M5C92_RS07545	COG0089	rRNA binding
M5C92_RS07550	COG0088	Forms part of the polypeptide exit tunnel
M5C92_RS07555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M5C92_RS07560	COG0051	transcription antitermination factor activity, RNA binding
M5C92_RS07565	COG0546	phosphoglycolate phosphatase activity
M5C92_RS07575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5C92_RS07580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M5C92_RS07585	COG0049	tRNA binding
M5C92_RS07590	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M5C92_RS07595	COG0833	amino acid
M5C92_RS07600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M5C92_RS07605	COG0085	RNA polymerase activity
M5C92_RS07610	COG0222	ribosome binding
M5C92_RS07615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M5C92_RS07625	COG0081	regulation of translation
M5C92_RS07630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M5C92_RS07635	COG0250	Participates in transcription elongation, termination and antitermination
M5C92_RS07650	COG0436	Aminotransferase
M5C92_RS07660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M5C92_RS07675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M5C92_RS07685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M5C92_RS07705	COG1666	GTP binding
M5C92_RS07715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5C92_RS07720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5C92_RS07725	COG5401	PFAM Sporulation and spore germination
M5C92_RS07730	COG5000	phosphorelay sensor kinase activity
M5C92_RS07730	COG5002	protein histidine kinase activity
M5C92_RS07735	COG0745	RESPONSE REGULATOR receiver
M5C92_RS07755	COG0714	Associated with various cellular activities
M5C92_RS07800	COG0483	inositol monophosphate 1-phosphatase activity
M5C92_RS07815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M5C92_RS07840	COG0438	transferase activity, transferring glycosyl groups
M5C92_RS07840	COG1216	Glycosyl transferase, family 2
M5C92_RS07910	COG0673	inositol 2-dehydrogenase activity
M5C92_RS07935	COG1088	dTDP-glucose 4,6-dehydratase activity
M5C92_RS07950	COG1316	TRANSCRIPTIONal
M5C92_RS07955	COG1316	TRANSCRIPTIONal
M5C92_RS07965	COG0642	Histidine kinase
M5C92_RS07970	COG0745	RESPONSE REGULATOR receiver
M5C92_RS07985	COG0424	maF-like protein
M5C92_RS08020	COG1217	gtp-binding protein TYPA
M5C92_RS08030	COG1132	(ABC) transporter
M5C92_RS08060	COG0321	lipoyl(octanoyl) transferase activity
M5C92_RS08065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M5C92_RS08075	COG1362	aminopeptidase activity
M5C92_RS08090	COG2838	Isocitrate dehydrogenase
M5C92_RS08095	COG2391	methyltransferase activity
M5C92_RS08100	COG0425	Belongs to the sulfur carrier protein TusA family
M5C92_RS08105	COG0366	Alpha amylase catalytic
M5C92_RS08110	COG1501	Belongs to the glycosyl hydrolase 31 family
M5C92_RS08120	COG0395	ABC-type sugar transport system, permease component
M5C92_RS08125	COG1175	transmembrane transport
M5C92_RS08130	COG1846	Transcriptional regulator
M5C92_RS08130	COG1940	carbohydrate kinase activity
M5C92_RS08155	COG1178	ABC-type Fe3 transport system permease component
M5C92_RS08160	COG3842	ATPase activity
M5C92_RS08165	COG1840	ABC-type Fe3 transport system, periplasmic component
M5C92_RS08185	COG4608	Belongs to the ABC transporter superfamily
M5C92_RS08190	COG0444	Belongs to the ABC transporter superfamily
M5C92_RS08195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5C92_RS08210	COG2116	formate transmembrane transporter activity
M5C92_RS08220	COG0242	peptide deformylase activity
M5C92_RS08225	COG1970	mechanosensitive ion channel activity
M5C92_RS08250	COG0456	acetyltransferase
M5C92_RS08250	COG1846	Transcriptional regulator
M5C92_RS08255	COG1780	Probably involved in ribonucleotide reductase function
M5C92_RS08265	COG0431	NADPH-dependent FMN reductase
M5C92_RS08270	COG3226	Transcriptional regulator
M5C92_RS08275	COG0477	Major facilitator Superfamily
M5C92_RS08285	COG1834	amidinotransferase
M5C92_RS08290	COG0549	Belongs to the carbamate kinase family
M5C92_RS08295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M5C92_RS08315	COG0395	ABC-type sugar transport system, permease component
M5C92_RS08330	COG0366	Alpha amylase catalytic
M5C92_RS08345	COG0477	Major facilitator Superfamily
M5C92_RS08400	COG0012	GTP binding
M5C92_RS08405	COG1322	Protein conserved in bacteria
M5C92_RS08410	COG1162	GTPase activity
M5C92_RS08425	COG4555	ABC transporter
M5C92_RS08440	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M5C92_RS08450	COG1722	exodeoxyribonuclease VII activity
M5C92_RS08455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5C92_RS08460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M5C92_RS08470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5C92_RS08475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5C92_RS08480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5C92_RS08495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5C92_RS08500	COG1012	belongs to the aldehyde dehydrogenase family
M5C92_RS08515	COG1131	(ABC) transporter
M5C92_RS08520	COG1725	Transcriptional regulator
M5C92_RS08545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M5C92_RS08565	COG0148	phosphopyruvate hydratase activity
M5C92_RS08580	COG0193	aminoacyl-tRNA hydrolase activity
M5C92_RS08585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M5C92_RS08595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M5C92_RS08605	COG1309	transcriptional regulator
M5C92_RS08620	COG4152	abc transporter atp-binding protein
M5C92_RS08625	COG1668	transmembrane transport
M5C92_RS08635	COG0488	(ABC) transporter
M5C92_RS08640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M5C92_RS08645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M5C92_RS08655	COG0084	hydrolase, TatD family'
M5C92_RS08660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5C92_RS08665	COG1335	isochorismatase
M5C92_RS08685	COG2873	o-acetylhomoserine
M5C92_RS08705	COG1131	(ABC) transporter
M5C92_RS08720	COG2813	Specifically methylates the guanine in position
M5C92_RS08750	COG1620	l-lactate permease
M5C92_RS08755	COG0247	lactate metabolic process
M5C92_RS08765	COG1556	Lactate utilization protein
M5C92_RS08785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5C92_RS08790	COG2190	(PTS) system
M5C92_RS08795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5C92_RS08795	COG1263	PTS System
M5C92_RS08810	COG1051	belongs to the nudix hydrolase family
M5C92_RS08820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5C92_RS08830	COG3711	transcriptional antiterminator
M5C92_RS08840	COG1511	domain protein
M5C92_RS08850	COG2848	UPF0210 protein
M5C92_RS08855	COG3830	Belongs to the UPF0237 family
M5C92_RS08870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M5C92_RS08875	COG0254	rRNA binding
M5C92_RS08880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M5C92_RS08885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M5C92_RS08890	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M5C92_RS08905	COG0477	Major facilitator Superfamily
M5C92_RS08910	COG0657	acetylesterase activity
M5C92_RS08915	COG2188	Transcriptional regulator
M5C92_RS08920	COG1120	ATPase activity
M5C92_RS08925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5C92_RS08930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5C92_RS08935	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M5C92_RS08950	COG0596	Alpha beta hydrolase
M5C92_RS08970	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5C92_RS09030	COG0791	NLP P60 protein
M5C92_RS09030	COG1388	LysM domain
M5C92_RS09040	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M5C92_RS09045	COG2252	PERMEase
M5C92_RS09060	COG1278	Cold shock
M5C92_RS09070	COG1842	Phage shock protein A
M5C92_RS09080	COG0745	RESPONSE REGULATOR receiver
M5C92_RS09085	COG2205	protein histidine kinase activity
M5C92_RS09095	COG4221	oxidoreductase activity
M5C92_RS09110	COG0459	protein refolding
M5C92_RS09125	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M5C92_RS09170	COG0673	inositol 2-dehydrogenase activity
M5C92_RS09180	COG1653	transport
M5C92_RS09185	COG1175	transmembrane transport
M5C92_RS09215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M5C92_RS09230	COG1966	Carbon starvation protein
M5C92_RS09255	COG2233	PERMEase
M5C92_RS09270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5C92_RS09275	COG0215	cysteine-tRNA ligase activity
M5C92_RS09300	COG2376	Dihydroxyacetone kinase
M5C92_RS09315	COG3775	system Galactitol-specific IIC component
M5C92_RS09335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M5C92_RS09340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M5C92_RS09355	COG5002	protein histidine kinase activity
M5C92_RS09370	COG0588	phosphoglycerate mutase activity
M5C92_RS09415	COG1120	ATPase activity
M5C92_RS09420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5C92_RS09450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M5C92_RS09455	COG0667	Aldo Keto reductase
M5C92_RS09465	COG0710	3-dehydroquinate dehydratase activity
M5C92_RS09495	COG0714	Associated with various cellular activities
M5C92_RS09510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M5C92_RS09515	COG1950	PFAM Membrane protein of
M5C92_RS09520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M5C92_RS09525	COG0586	Pfam SNARE associated Golgi protein
M5C92_RS09560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5C92_RS09565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5C92_RS09570	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5C92_RS09575	COG1120	ATPase activity
M5C92_RS09595	COG1063	alcohol dehydrogenase
M5C92_RS09600	COG1609	Transcriptional regulator
M5C92_RS09605	COG2271	Major facilitator Superfamily
M5C92_RS09610	COG0483	inositol monophosphate 1-phosphatase activity
M5C92_RS09615	COG1879	ABC-type sugar transport system periplasmic component
M5C92_RS09620	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5C92_RS09630	COG0673	inositol 2-dehydrogenase activity
M5C92_RS09640	COG0673	inositol 2-dehydrogenase activity
M5C92_RS09645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5C92_RS09665	COG3718	enzyme involved in inositol metabolism
M5C92_RS09670	COG3962	Belongs to the TPP enzyme family
M5C92_RS09680	COG4604	ABC transporter, ATP-binding protein
M5C92_RS09685	COG4605	iron ion homeostasis
M5C92_RS09690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5C92_RS09695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5C92_RS09700	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M5C92_RS09710	COG0673	inositol 2-dehydrogenase activity
M5C92_RS09720	COG1175	transmembrane transport
M5C92_RS09725	COG0395	ABC-type sugar transport system, permease component
M5C92_RS09730	COG1063	alcohol dehydrogenase
M5C92_RS09735	COG0156	8-amino-7-oxononanoate synthase activity
M5C92_RS09745	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M5C92_RS09745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M5C92_RS09750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M5C92_RS09755	COG1904	glucuronate isomerase
M5C92_RS09780	COG3142	Participates in the control of copper homeostasis
M5C92_RS09795	COG1940	carbohydrate kinase activity
M5C92_RS09805	COG0601	transmembrane transport
M5C92_RS09810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5C92_RS09820	COG1940	carbohydrate kinase activity
M5C92_RS09825	COG1940	carbohydrate kinase activity
M5C92_RS09825	COG1846	Transcriptional regulator
M5C92_RS09835	COG1175	transmembrane transport
M5C92_RS09865	COG2801	Transposase and inactivated derivatives
M5C92_RS09910	COG2801	Transposase and inactivated derivatives
M5C92_RS09915	COG1132	(ABC) transporter
M5C92_RS09920	COG2375	cellular response to nickel ion
M5C92_RS09920	COG1132	(ABC) transporter
M5C92_RS09925	COG1129	ABC transporter
M5C92_RS09930	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5C92_RS09945	COG0471	metal ion transport
M5C92_RS09975	COG1129	ABC transporter
M5C92_RS09980	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5C92_RS09990	COG1879	ABC-type sugar transport system periplasmic component
M5C92_RS10000	COG1070	Carbohydrate kinase
M5C92_RS10025	COG1252	NADH dehydrogenase
M5C92_RS10035	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M5C92_RS10070	COG1518	maintenance of DNA repeat elements
M5C92_RS10125	COG1643	Atp-dependent helicase
M5C92_RS10140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5C92_RS10170	COG1136	(ABC) transporter
M5C92_RS10170	COG0577	efflux transmembrane transporter activity
M5C92_RS10175	COG1136	(ABC) transporter
M5C92_RS10190	COG0745	RESPONSE REGULATOR receiver
M5C92_RS10195	COG2205	protein histidine kinase activity
M5C92_RS10200	COG0343	queuine tRNA-ribosyltransferase activity
M5C92_RS10210	COG1428	Deoxynucleoside kinase
M5C92_RS10255	COG0351	phosphomethylpyrimidine kinase
M5C92_RS10265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M5C92_RS10275	COG2814	Major facilitator Superfamily
M5C92_RS10280	COG0305	Participates in initiation and elongation during chromosome replication
M5C92_RS10300	COG0359	binds to the 23S rRNA
M5C92_RS10305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M5C92_RS10315	COG0360	Binds together with S18 to 16S ribosomal RNA
M5C92_RS10320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5C92_RS10325	COG0628	permease
M5C92_RS10335	COG0617	tRNA 3'-terminal CCA addition
M5C92_RS10355	COG0492	ferredoxin-NADP+ reductase activity
M5C92_RS10360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5C92_RS10365	COG1181	Belongs to the D-alanine--D-alanine ligase family
M5C92_RS10375	COG1192	Involved in chromosome partitioning
M5C92_RS10380	COG0357	Ribosomal RNA small subunit methyltransferase G
M5C92_RS10390	COG0706	membrane insertase activity
M5C92_RS10395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M5C92_RS10400	COG0594	ribonuclease P activity
M5C92_RS10405	COG0230	Belongs to the bacterial ribosomal protein bL34 family