locus-tag	class	description
M1F28_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M1F28_RS00010	COG0592	DNA-directed DNA polymerase activity
M1F28_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M1F28_RS00025	COG0187	DNA topoisomerase II activity
M1F28_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M1F28_RS00075	COG0457	Tetratricopeptide repeat
M1F28_RS00075	COG0705	Rhomboid family
M1F28_RS00085	COG3764	Sortase (surface protein transpeptidase)
M1F28_RS00115	COG1716	ATPase activity
M1F28_RS00120	COG1716	ATPase activity
M1F28_RS00120	COG0842	Transport permease protein
M1F28_RS00120	COG1131	(ABC) transporter
M1F28_RS00150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1F28_RS00155	COG1854	S-ribosylhomocysteine lyase activity
M1F28_RS00170	COG1780	Probably involved in ribonucleotide reductase function
M1F28_RS00175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1F28_RS00180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1F28_RS00190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1F28_RS00195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1F28_RS00210	COG0395	ABC-type sugar transport system, permease component
M1F28_RS00215	COG1175	transmembrane transport
M1F28_RS00245	COG1643	Atp-dependent helicase
M1F28_RS00250	COG2197	response regulator
M1F28_RS00255	COG4585	Histidine kinase
M1F28_RS00265	COG1131	(ABC) transporter
M1F28_RS00275	COG1136	(ABC) transporter
M1F28_RS00285	COG2197	response regulator
M1F28_RS00295	COG1328	CTP reductase activity
M1F28_RS00315	COG1136	(ABC) transporter
M1F28_RS00315	COG0577	efflux transmembrane transporter activity
M1F28_RS00320	COG1414	Transcriptional regulator
M1F28_RS00325	COG0246	Mannitol dehydrogenase
M1F28_RS00330	COG1312	Catalyzes the dehydration of D-mannonate
M1F28_RS00335	COG0800	Aldolase
M1F28_RS00340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1F28_RS00345	COG2226	methyltransferase
M1F28_RS00355	COG1120	ATPase activity
M1F28_RS00365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F28_RS00380	COG1132	(ABC) transporter
M1F28_RS00385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M1F28_RS00390	COG1609	Transcriptional regulator
M1F28_RS00405	COG1175	transmembrane transport
M1F28_RS00410	COG0395	ABC-type sugar transport system, permease component
M1F28_RS00450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M1F28_RS00480	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1F28_RS00485	COG1879	ABC-type sugar transport system periplasmic component
M1F28_RS00490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M1F28_RS00490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M1F28_RS00495	COG1486	melibiose metabolic process
M1F28_RS00520	COG0561	phosphatase activity
M1F28_RS00525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M1F28_RS00540	COG0077	Prephenate dehydratase
M1F28_RS00565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M1F28_RS00585	COG4868	Belongs to the UPF0371 family
M1F28_RS00590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1F28_RS00640	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1F28_RS00650	COG0315	cyclic pyranopterin monophosphate synthase activity
M1F28_RS00660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1F28_RS00685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1F28_RS00720	COG2267	carboxylic ester hydrolase activity
M1F28_RS00770	COG3655	Transcriptional regulator
M1F28_RS00780	COG2890	protein-(glutamine-N5) methyltransferase activity
M1F28_RS00780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1F28_RS00785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M1F28_RS00785	COG1754	DNA topoisomerase type I activity
M1F28_RS00790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M1F28_RS00795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1F28_RS00850	COG0717	Belongs to the dCTP deaminase family
M1F28_RS00855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1F28_RS00855	COG2111	Na H antiporter
M1F28_RS00860	COG1006	Multisubunit Na H antiporter MnhC subunit
M1F28_RS00865	COG0651	ATP synthesis coupled electron transport
M1F28_RS00895	COG4149	molybdate abc transporter
M1F28_RS00900	COG3842	ATPase activity
M1F28_RS00915	COG0662	Cupin 2, conserved barrel domain protein
M1F28_RS00960	COG1940	carbohydrate kinase activity
M1F28_RS00965	COG0390	transport system, permease component
M1F28_RS00975	COG1505	serine-type exopeptidase activity
M1F28_RS00985	COG0437	4 iron, 4 sulfur cluster binding
M1F28_RS00990	COG0243	molybdopterin cofactor binding
M1F28_RS00995	COG1937	Protein conserved in bacteria
M1F28_RS01000	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1F28_RS01010	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M1F28_RS01015	COG0540	Belongs to the ATCase OTCase family
M1F28_RS01020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M1F28_RS01025	COG0284	orotidine-5'-phosphate decarboxylase activity
M1F28_RS01030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M1F28_RS01035	COG0167	dihydroorotate dehydrogenase activity
M1F28_RS01040	COG0443	Heat shock 70 kDa protein
M1F28_RS01045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M1F28_RS01050	COG0484	heat shock protein binding
M1F28_RS01075	COG0584	glycerophosphoryl diester phosphodiesterase
M1F28_RS01080	COG1506	peptidase
M1F28_RS01080	COG0823	Involved in the tonB-independent uptake of proteins
M1F28_RS01090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1F28_RS01120	COG1028	Short-chain dehydrogenase reductase Sdr
M1F28_RS01135	COG0494	nUDIX hydrolase
M1F28_RS01150	COG0191	fructose-bisphosphate aldolase activity
M1F28_RS01160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1F28_RS01165	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
M1F28_RS01170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M1F28_RS01175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1F28_RS01205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1F28_RS01235	COG0039	L-malate dehydrogenase activity
M1F28_RS01240	COG0728	peptidoglycan biosynthetic process
M1F28_RS01265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1F28_RS01290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M1F28_RS01295	COG0494	nUDIX hydrolase
M1F28_RS01295	COG0406	alpha-ribazole phosphatase activity
M1F28_RS01300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1F28_RS01315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1F28_RS01320	COG0306	phosphate transporter
M1F28_RS01330	COG1115	amino acid carrier protein
M1F28_RS01340	COG0737	Belongs to the 5'-nucleotidase family
M1F28_RS01355	COG3485	protocatechuate 3,4-dioxygenase
M1F28_RS01360	COG0354	folic acid binding
M1F28_RS01370	COG1490	D-aminoacyl-tRNA deacylase activity
M1F28_RS01390	COG0738	Major facilitator superfamily
M1F28_RS01395	COG2390	Transcriptional regulator
M1F28_RS01415	COG1349	DNA-binding transcription factor activity
M1F28_RS01435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1F28_RS01440	COG2376	Dihydroxyacetone kinase
M1F28_RS01450	COG0698	ribose 5-phosphate isomerase
M1F28_RS01455	COG0730	response to heat
M1F28_RS01460	COG0641	radical SAM
M1F28_RS01465	COG2814	Major facilitator Superfamily
M1F28_RS01470	COG1609	Transcriptional regulator
M1F28_RS01475	COG3119	arylsulfatase activity
M1F28_RS01495	COG3842	ATPase activity
M1F28_RS01500	COG1940	carbohydrate kinase activity
M1F28_RS01505	COG2115	Belongs to the xylose isomerase family
M1F28_RS01510	COG1070	Carbohydrate kinase
M1F28_RS01515	COG1653	transport
M1F28_RS01520	COG1175	transmembrane transport
M1F28_RS01525	COG0395	ABC-type sugar transport system, permease component
M1F28_RS01530	COG3119	arylsulfatase activity
M1F28_RS01540	COG2390	Transcriptional regulator
M1F28_RS01550	COG2610	gluconate transmembrane transporter activity
M1F28_RS01570	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M1F28_RS01575	COG3250	beta-galactosidase activity
M1F28_RS01580	COG1869	D-ribose catabolic process
M1F28_RS01590	COG1879	ABC-type sugar transport system periplasmic component
M1F28_RS01595	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1F28_RS01600	COG1129	ABC transporter
M1F28_RS01605	COG1609	Transcriptional regulator
M1F28_RS01610	COG2226	methyltransferase
M1F28_RS01615	COG1116	anion transmembrane transporter activity
M1F28_RS01615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1F28_RS01635	COG0737	Belongs to the 5'-nucleotidase family
M1F28_RS01645	COG1609	Transcriptional regulator
M1F28_RS01650	COG2271	Major facilitator Superfamily
M1F28_RS01655	COG1285	pathogenesis
M1F28_RS01680	COG3177	Filamentation induced by cAMP protein fic
M1F28_RS01715	COG1518	maintenance of DNA repeat elements
M1F28_RS01725	COG3609	addiction module antidote protein, CC2985 family
M1F28_RS01740	COG0366	Alpha amylase catalytic
M1F28_RS01745	COG0395	ABC-type sugar transport system, permease component
M1F28_RS01750	COG1175	transmembrane transport
M1F28_RS01765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1F28_RS01765	COG0574	Belongs to the PEP-utilizing enzyme family
M1F28_RS01770	COG0247	lactate metabolic process
M1F28_RS01770	COG0277	FAD linked oxidase domain protein
M1F28_RS01780	COG2267	carboxylic ester hydrolase activity
M1F28_RS01785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1F28_RS01790	COG0791	NLP P60 protein
M1F28_RS01795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1F28_RS01810	COG0037	tRNA processing
M1F28_RS01820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1F28_RS01825	COG0302	gtp cyclohydrolase
M1F28_RS01835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1F28_RS01855	COG1609	Transcriptional regulator
M1F28_RS01875	COG3250	beta-galactosidase activity
M1F28_RS01885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1F28_RS01885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1F28_RS01890	COG1461	Dihydroxyacetone kinase
M1F28_RS01895	COG2376	Dihydroxyacetone kinase
M1F28_RS01905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M1F28_RS01910	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M1F28_RS01920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M1F28_RS01925	COG2409	Drug exporters of the RND superfamily
M1F28_RS01930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1F28_RS01935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M1F28_RS01950	COG0247	lactate metabolic process
M1F28_RS01955	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
M1F28_RS01960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M1F28_RS01975	COG1194	a g-specific adenine glycosylase
M1F28_RS01985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M1F28_RS01990	COG0569	domain protein
M1F28_RS01995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1F28_RS02010	COG1846	Transcriptional regulator
M1F28_RS02015	COG0406	alpha-ribazole phosphatase activity
M1F28_RS02040	COG0395	ABC-type sugar transport system, permease component
M1F28_RS02045	COG1175	transmembrane transport
M1F28_RS02055	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M1F28_RS02060	COG4948	Mandelate Racemase Muconate Lactonizing
M1F28_RS02065	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M1F28_RS02070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1F28_RS02075	COG1169	isochorismate synthase
M1F28_RS02080	COG2226	methyltransferase
M1F28_RS02085	COG0644	oxidoreductase
M1F28_RS02095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1F28_RS02100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1F28_RS02105	COG0649	NAD binding
M1F28_RS02115	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1F28_RS02120	COG1034	ATP synthesis coupled electron transport
M1F28_RS02125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M1F28_RS02130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1F28_RS02135	COG0839	Belongs to the complex I subunit 6 family
M1F28_RS02140	COG0713	ATP synthesis coupled electron transport
M1F28_RS02145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1F28_RS02155	COG1007	ATP synthesis coupled electron transport
M1F28_RS02160	COG0142	geranyltranstransferase activity
M1F28_RS02165	COG0653	protein targeting
M1F28_RS02205	COG0419	ATPase involved in DNA repair
M1F28_RS02210	COG0420	3'-5' exonuclease activity
M1F28_RS02215	COG0483	inositol monophosphate 1-phosphatase activity
M1F28_RS02220	COG1162	GTPase activity
M1F28_RS02225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1F28_RS02250	COG0657	acetylesterase activity
M1F28_RS02265	COG0601	transmembrane transport
M1F28_RS02270	COG0444	Belongs to the ABC transporter superfamily
M1F28_RS02275	COG4608	Belongs to the ABC transporter superfamily
M1F28_RS02280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1F28_RS02290	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M1F28_RS02295	COG0363	glucosamine-6-phosphate deaminase activity
M1F28_RS02305	COG1595	DNA-templated transcription, initiation
M1F28_RS02320	COG3103	Sh3 type 3 domain protein
M1F28_RS02320	COG1388	LysM domain
M1F28_RS02320	COG0791	NLP P60 protein
M1F28_RS02330	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1F28_RS02330	COG0567	Dehydrogenase, E1 component
M1F28_RS02335	COG1253	flavin adenine dinucleotide binding
M1F28_RS02345	COG0739	heme binding
M1F28_RS02350	COG0584	glycerophosphoryl diester phosphodiesterase
M1F28_RS02390	COG0018	arginyl-trna synthetase
M1F28_RS02400	COG0460	homoserine dehydrogenase
M1F28_RS02405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1F28_RS02410	COG0083	homoserine kinase activity
M1F28_RS02425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M1F28_RS02450	COG0356	it plays a direct role in the translocation of protons across the membrane
M1F28_RS02455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M1F28_RS02460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M1F28_RS02465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M1F28_RS02470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M1F28_RS02475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M1F28_RS02480	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M1F28_RS02485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M1F28_RS02495	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
M1F28_RS02540	COG1609	Transcriptional regulator
M1F28_RS02550	COG1175	transmembrane transport
M1F28_RS02555	COG3833	ABC-type maltose transport systems, permease component
M1F28_RS02565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M1F28_RS02570	COG3281	Trehalose synthase
M1F28_RS02575	COG0366	Alpha amylase catalytic
M1F28_RS02580	COG0366	Alpha amylase catalytic
M1F28_RS02610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1F28_RS02615	COG0058	SHG alpha-glucan phosphorylase activity
M1F28_RS02620	COG0180	Tryptophanyl-tRNA synthetase
M1F28_RS02650	COG3480	Lon protease (S16) C-terminal proteolytic domain
M1F28_RS02660	COG1615	UPF0182 protein
M1F28_RS02665	COG1470	cell adhesion involved in biofilm formation
M1F28_RS02665	COG0366	Alpha amylase catalytic
M1F28_RS02690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1F28_RS02695	COG1131	(ABC) transporter
M1F28_RS02705	COG0387	Pfam Sodium calcium exchanger
M1F28_RS02715	COG1053	succinate dehydrogenase
M1F28_RS02725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1F28_RS02740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M1F28_RS02775	COG4585	Histidine kinase
M1F28_RS02780	COG2135	peptidase activity
M1F28_RS02785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M1F28_RS02790	COG2188	Transcriptional regulator
M1F28_RS02795	COG1397	ADP-ribosylglycohydrolase
M1F28_RS02805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1F28_RS02820	COG1404	Belongs to the peptidase S8 family
M1F28_RS02825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1F28_RS02830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1F28_RS02835	COG0154	amidase activity
M1F28_RS02840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1F28_RS02890	COG0129	dihydroxy-acid dehydratase activity
M1F28_RS02895	COG2985	domain, Protein
M1F28_RS02895	COG0569	domain protein
M1F28_RS02905	COG0440	acetolactate synthase activity
M1F28_RS02910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M1F28_RS02930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1F28_RS02935	COG1882	Formate acetyltransferase
M1F28_RS02965	COG0438	transferase activity, transferring glycosyl groups
M1F28_RS02970	COG4750	Nucleotidyl transferase
M1F28_RS02975	COG3475	LICD family
M1F28_RS02980	COG1216	Glycosyl transferase, family 2
M1F28_RS02980	COG1442	glycosyl transferase family 8
M1F28_RS03010	COG2244	polysaccharide biosynthetic process
M1F28_RS03015	COG0463	Glycosyl transferase, family 2
M1F28_RS03050	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1F28_RS03080	COG1946	Acyl-CoA thioesterase
M1F28_RS03095	COG0519	Catalyzes the synthesis of GMP from XMP
M1F28_RS03105	COG2354	Protein conserved in bacteria
M1F28_RS03110	COG3590	peptidase
M1F28_RS03120	COG1045	serine acetyltransferase
M1F28_RS03130	COG1739	Uncharacterized protein family UPF0029
M1F28_RS03145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1F28_RS03160	COG0488	(ABC) transporter
M1F28_RS03175	COG1609	Transcriptional regulator
M1F28_RS03180	COG3250	beta-galactosidase activity
M1F28_RS03200	COG0667	Aldo Keto reductase
M1F28_RS03205	COG0544	peptidyl-prolyl cis-trans isomerase activity
M1F28_RS03210	COG0740	serine-type endopeptidase activity
M1F28_RS03215	COG0740	serine-type endopeptidase activity
M1F28_RS03220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M1F28_RS03225	COG0287	Prephenate dehydrogenase
M1F28_RS03225	COG1605	Chorismate mutase
M1F28_RS03245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M1F28_RS03260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1F28_RS03265	COG0285	dihydrofolate synthase activity
M1F28_RS03270	COG0105	UTP biosynthetic process
M1F28_RS03310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M1F28_RS03315	COG0228	four-way junction DNA binding
M1F28_RS03320	COG1837	Belongs to the UPF0109 family
M1F28_RS03325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1F28_RS03335	COG0335	large ribosomal subunit rRNA binding
M1F28_RS03340	COG0681	Belongs to the peptidase S26 family
M1F28_RS03345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1F28_RS03370	COG4974	Belongs to the 'phage' integrase family
M1F28_RS03375	COG1388	LysM domain
M1F28_RS03375	COG4942	peptidase
M1F28_RS03380	COG2860	membrane
M1F28_RS03385	COG0052	Belongs to the universal ribosomal protein uS2 family
M1F28_RS03390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M1F28_RS03400	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M1F28_RS03405	COG0644	oxidoreductase
M1F28_RS03430	COG0233	cytoplasmic translational termination
M1F28_RS03440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M1F28_RS03450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M1F28_RS03455	COG0750	zinc metalloprotease
M1F28_RS03460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M1F28_RS03470	COG0442	prolyl-tRNA aminoacylation
M1F28_RS03480	COG0779	Required for maturation of 30S ribosomal subunits
M1F28_RS03495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M1F28_RS03500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M1F28_RS03505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1F28_RS03510	COG3852	Histidine kinase
M1F28_RS03515	COG0745	RESPONSE REGULATOR receiver
M1F28_RS03520	COG2271	Major facilitator Superfamily
M1F28_RS03530	COG3842	ATPase activity
M1F28_RS03560	COG1131	(ABC) transporter
M1F28_RS03575	COG1185	polyribonucleotide nucleotidyltransferase activity
M1F28_RS03580	COG0612	Peptidase, M16
M1F28_RS03585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M1F28_RS03590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M1F28_RS03605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M1F28_RS03610	COG1674	ftsk spoiiie
M1F28_RS03625	COG1546	Belongs to the CinA family
M1F28_RS03625	COG1058	Belongs to the CinA family
M1F28_RS03630	COG1396	sequence-specific DNA binding
M1F28_RS03640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M1F28_RS03645	COG2137	regulation of response to DNA damage stimulus
M1F28_RS03650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M1F28_RS03655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M1F28_RS03665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1F28_RS03675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1F28_RS03685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1F28_RS03690	COG0318	PFAM AMP-dependent synthetase and ligase
M1F28_RS03695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1F28_RS03715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1F28_RS03725	COG2001	Belongs to the MraZ family
M1F28_RS03730	COG0275	rRNA processing
M1F28_RS03740	COG0768	penicillin binding
M1F28_RS03745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1F28_RS03750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1F28_RS03755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M1F28_RS03760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M1F28_RS03765	COG0772	Belongs to the SEDS family
M1F28_RS03770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M1F28_RS03775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1F28_RS03785	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1F28_RS03795	COG1799	cell septum assembly
M1F28_RS03810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M1F28_RS03825	COG0587	DNA-directed DNA polymerase activity
M1F28_RS03840	COG0735	belongs to the Fur family
M1F28_RS03845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1F28_RS03850	COG1121	(ABC) transporter
M1F28_RS03860	COG0423	glycine-tRNA ligase activity
M1F28_RS03885	COG0358	DNA primase activity
M1F28_RS03895	COG0805	protein transport
M1F28_RS03900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M1F28_RS03935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F28_RS03940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M1F28_RS03975	COG1090	epimerase
M1F28_RS03995	COG0009	L-threonylcarbamoyladenylate synthase
M1F28_RS04015	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M1F28_RS04040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M1F28_RS04045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M1F28_RS04050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1F28_RS04070	COG1940	carbohydrate kinase activity
M1F28_RS04085	COG0174	glutamine synthetase
M1F28_RS04090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1F28_RS04100	COG0174	glutamine synthetase
M1F28_RS04120	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1F28_RS04125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1F28_RS04135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M1F28_RS04150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1F28_RS04190	COG0205	6-phosphofructokinase activity
M1F28_RS04195	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M1F28_RS04200	COG2815	serine threonine protein kinase
M1F28_RS04200	COG0515	serine threonine protein kinase
M1F28_RS04215	COG0142	geranyltranstransferase activity
M1F28_RS04230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M1F28_RS04235	COG1199	ATP-dependent helicase activity
M1F28_RS04235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1F28_RS04245	COG0187	DNA topoisomerase II activity
M1F28_RS04260	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M1F28_RS04300	COG0569	domain protein
M1F28_RS04315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1F28_RS04325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M1F28_RS04405	COG2197	response regulator
M1F28_RS04410	COG1760	l-serine dehydratase
M1F28_RS04415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M1F28_RS04420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1F28_RS04430	COG0438	transferase activity, transferring glycosyl groups
M1F28_RS04440	COG1051	belongs to the nudix hydrolase family
M1F28_RS04445	COG0217	transcriptional regulatory protein
M1F28_RS04450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M1F28_RS04455	COG0632	four-way junction helicase activity
M1F28_RS04460	COG2255	four-way junction helicase activity
M1F28_RS04470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1F28_RS04475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1F28_RS04480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M1F28_RS04485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1F28_RS04495	COG1196	nuclear chromosome segregation
M1F28_RS04500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1F28_RS04505	COG0124	histidyl-tRNA synthetase
M1F28_RS04510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1F28_RS04515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1F28_RS04535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M1F28_RS04550	COG2409	Drug exporters of the RND superfamily
M1F28_RS04560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M1F28_RS04570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M1F28_RS04575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1F28_RS04595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M1F28_RS04605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M1F28_RS04610	COG2217	Heavy metal translocating P-type atpase
M1F28_RS04615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M1F28_RS04620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M1F28_RS04625	COG0505	Belongs to the CarA family
M1F28_RS04630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M1F28_RS04640	COG0194	GDP metabolic process
M1F28_RS04645	COG1758	RNA polymerase activity
M1F28_RS04655	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M1F28_RS04660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1F28_RS04665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M1F28_RS04675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1F28_RS04680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1F28_RS04685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1F28_RS04690	COG0140	phosphoribosyl-ATP diphosphatase activity
M1F28_RS04695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1F28_RS04725	COG4581	dead DEAH box helicase
M1F28_RS04735	COG1216	Glycosyl transferase, family 2
M1F28_RS04775	COG0205	6-phosphofructokinase activity
M1F28_RS04780	COG1160	GTP binding
M1F28_RS04785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M1F28_RS04800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1F28_RS04825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1F28_RS04840	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M1F28_RS04845	COG0149	triose-phosphate isomerase activity
M1F28_RS04850	COG0126	phosphoglycerate kinase activity
M1F28_RS04855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1F28_RS04860	COG1481	regulation of sporulation
M1F28_RS04875	COG0322	excinuclease ABC activity
M1F28_RS04880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1F28_RS04900	COG0556	nucleotide-excision repair
M1F28_RS04905	COG0237	dephospho-CoA kinase activity
M1F28_RS04910	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M1F28_RS04915	COG1136	(ABC) transporter
M1F28_RS04925	COG0539	negative regulation of cytoplasmic translation
M1F28_RS04950	COG0469	pyruvate kinase activity
M1F28_RS04955	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M1F28_RS04960	COG0134	indole-3-glycerol-phosphate synthase activity
M1F28_RS04970	COG0107	imidazoleglycerol-phosphate synthase activity
M1F28_RS04985	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
M1F28_RS04995	COG4122	O-methyltransferase activity
M1F28_RS05000	COG1222	aaa ATPase
M1F28_RS05020	COG1968	undecaprenyl-diphosphatase activity
M1F28_RS05035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M1F28_RS05045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1F28_RS05045	COG0519	Catalyzes the synthesis of GMP from XMP
M1F28_RS05070	COG0587	DNA-directed DNA polymerase activity
M1F28_RS05085	COG1881	PFAM PEBP family protein
M1F28_RS05120	COG1119	ATPase activity
M1F28_RS05125	COG0297	glycogen (starch) synthase activity
M1F28_RS05135	COG0577	efflux transmembrane transporter activity
M1F28_RS05135	COG1136	(ABC) transporter
M1F28_RS05145	COG3830	Belongs to the UPF0237 family
M1F28_RS05145	COG0560	Phosphoserine phosphatase
M1F28_RS05155	COG0488	(ABC) transporter
M1F28_RS05160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M1F28_RS05165	COG2151	metal-sulfur cluster biosynthetic enzyme
M1F28_RS05180	COG0396	ATPase activity
M1F28_RS05210	COG0728	peptidoglycan biosynthetic process
M1F28_RS05230	COG0497	DNA recombination
M1F28_RS05235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1F28_RS05250	COG0647	UMP catabolic process
M1F28_RS05280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1F28_RS05285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1F28_RS05290	COG1121	(ABC) transporter
M1F28_RS05295	COG0803	Belongs to the bacterial solute-binding protein 9 family
M1F28_RS05300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1F28_RS05315	COG1476	TRANSCRIPTIONal
M1F28_RS05325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1F28_RS05330	COG1438	arginine binding
M1F28_RS05345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M1F28_RS05350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1F28_RS05365	COG1902	pentaerythritol trinitrate reductase activity
M1F28_RS05370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1F28_RS05385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M1F28_RS05390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M1F28_RS05400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M1F28_RS05405	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1F28_RS05415	COG0131	Imidazoleglycerol-phosphate dehydratase
M1F28_RS05425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1F28_RS05430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1F28_RS05435	COG1381	Involved in DNA repair and RecF pathway recombination
M1F28_RS05440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1F28_RS05475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M1F28_RS05485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1F28_RS05490	COG0484	heat shock protein binding
M1F28_RS05495	COG1420	regulation of RNA biosynthetic process
M1F28_RS05515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1F28_RS05520	COG0481	GTPase activity
M1F28_RS05545	COG0268	Binds directly to 16S ribosomal RNA
M1F28_RS05555	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M1F28_RS05560	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M1F28_RS05580	COG0433	COG0433 Predicted ATPase
M1F28_RS05595	COG0495	leucyl-tRNA aminoacylation
M1F28_RS05620	COG0813	purine-nucleoside phosphorylase activity
M1F28_RS05630	COG1435	thymidine kinase activity
M1F28_RS05650	COG0803	Belongs to the bacterial solute-binding protein 9 family
M1F28_RS05660	COG1121	(ABC) transporter
M1F28_RS05665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1F28_RS05685	COG0671	phosphoesterase, PA-phosphatase related
M1F28_RS05705	COG1113	amino acid transport
M1F28_RS05710	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1F28_RS05710	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1F28_RS05720	COG2011	ABC-type metal ion transport system permease component
M1F28_RS05725	COG1464	Belongs to the NlpA lipoprotein family
M1F28_RS05730	COG1113	amino acid transport
M1F28_RS05740	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1F28_RS05745	COG2186	Transcriptional regulator
M1F28_RS05750	COG0477	Major facilitator Superfamily
M1F28_RS05760	COG0826	peptidase U32
M1F28_RS05765	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M1F28_RS05775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1F28_RS05815	COG0726	polysaccharide deacetylase
M1F28_RS05825	COG1609	Transcriptional regulator
M1F28_RS05835	COG0738	Major facilitator superfamily
M1F28_RS05840	COG0235	Class ii aldolase
M1F28_RS05870	COG0406	alpha-ribazole phosphatase activity
M1F28_RS05875	COG0799	negative regulation of ribosome biogenesis
M1F28_RS05885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M1F28_RS05890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M1F28_RS05900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M1F28_RS05910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M1F28_RS05915	COG1530	ribonuclease E activity
M1F28_RS05920	COG1271	oxidase subunit
M1F28_RS05925	COG1294	oxidase, subunit
M1F28_RS05930	COG4988	ABC transporter
M1F28_RS05935	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M1F28_RS05945	COG1132	(ABC) transporter
M1F28_RS05950	COG1132	(ABC) transporter
M1F28_RS05970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M1F28_RS05975	COG0571	ribonuclease III activity
M1F28_RS05990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M1F28_RS06005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M1F28_RS06015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1F28_RS06025	COG1181	Belongs to the D-alanine--D-alanine ligase family
M1F28_RS06030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1F28_RS06050	COG0438	transferase activity, transferring glycosyl groups
M1F28_RS06060	COG4975	Glucose uptake
M1F28_RS06065	COG0339	signal peptide processing
M1F28_RS06120	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1F28_RS06125	COG1022	Amp-dependent synthetase and ligase
M1F28_RS06150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M1F28_RS06155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M1F28_RS06165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1F28_RS06175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1F28_RS06200	COG0569	domain protein
M1F28_RS06200	COG2985	domain, Protein
M1F28_RS06215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1F28_RS06290	COG1846	Transcriptional regulator
M1F28_RS06325	COG1619	proteins homologs of microcin C7 resistance protein MccF
M1F28_RS06340	COG0739	heme binding
M1F28_RS06345	COG2177	Part of the ABC transporter FtsEX involved in
M1F28_RS06350	COG2884	Cell division ATP-binding protein ftsE
M1F28_RS06355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M1F28_RS06415	COG0513	Belongs to the DEAD box helicase family
M1F28_RS06420	COG2095	MarC family integral membrane protein
M1F28_RS06430	COG0006	proline dipeptidase activity
M1F28_RS06435	COG2239	Acts as a magnesium transporter
M1F28_RS06460	COG1611	Belongs to the LOG family
M1F28_RS06470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1F28_RS06475	COG1309	transcriptional regulator
M1F28_RS06480	COG2814	Major facilitator Superfamily
M1F28_RS06485	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M1F28_RS06505	COG1079	Belongs to the binding-protein-dependent transport system permease family
M1F28_RS06510	COG4603	Belongs to the binding-protein-dependent transport system permease family
M1F28_RS06515	COG3845	ABC transporter
M1F28_RS06520	COG1744	ABC transporter substrate-binding protein PnrA-like
M1F28_RS06525	COG0662	Cupin 2, conserved barrel domain protein
M1F28_RS06525	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M1F28_RS06540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M1F28_RS06545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M1F28_RS06555	COG1268	BioY protein
M1F28_RS06560	COG0736	holo-[acyl-carrier-protein] synthase activity
M1F28_RS06565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1F28_RS06570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1F28_RS06575	COG4770	biotin carboxylase activity
M1F28_RS06595	COG0644	oxidoreductase
M1F28_RS06600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M1F28_RS06615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1F28_RS06620	COG2271	Major facilitator Superfamily
M1F28_RS06625	COG2030	dehydratase
M1F28_RS06665	COG0039	L-malate dehydrogenase activity
M1F28_RS06675	COG0166	Belongs to the GPI family
M1F28_RS06680	COG0205	6-phosphofructokinase activity
M1F28_RS06710	COG0045	succinate-CoA ligase (ADP-forming) activity
M1F28_RS06715	COG2755	lipolytic protein G-D-S-L family
M1F28_RS06715	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M1F28_RS06730	COG0653	protein targeting
M1F28_RS06760	COG0542	response to heat
M1F28_RS06805	COG4974	Belongs to the 'phage' integrase family
M1F28_RS06830	COG0857	belongs to the CobB CobQ family
M1F28_RS06830	COG0280	phosphate acetyltransferase
M1F28_RS06835	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1F28_RS06850	COG1136	(ABC) transporter
M1F28_RS06860	COG0114	fumarate hydratase activity
M1F28_RS06865	COG0516	GMP reductase activity
M1F28_RS06890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1F28_RS06895	COG0151	Belongs to the GarS family
M1F28_RS06900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M1F28_RS06905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M1F28_RS06910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M1F28_RS06915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M1F28_RS06925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M1F28_RS06935	COG0428	transporter
M1F28_RS06940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M1F28_RS06945	COG0733	neurotransmitter:sodium symporter activity
M1F28_RS06955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1F28_RS06960	COG1053	succinate dehydrogenase
M1F28_RS06985	COG0802	atpase or kinase
M1F28_RS06990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1F28_RS07000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1F28_RS07005	COG1072	(Pantothenic acid kinase))
M1F28_RS07015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1F28_RS07020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M1F28_RS07030	COG4720	Psort location CytoplasmicMembrane, score
M1F28_RS07035	COG1122	ATPase activity
M1F28_RS07055	COG0101	tRNA pseudouridine synthase activity
M1F28_RS07060	COG1940	carbohydrate kinase activity
M1F28_RS07070	COG0765	amino acid transport
M1F28_RS07080	COG0789	Transcriptional regulator
M1F28_RS07090	COG0203	ribosomal protein L17
M1F28_RS07095	COG0202	RNA polymerase activity
M1F28_RS07105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M1F28_RS07110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M1F28_RS07115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M1F28_RS07125	COG0563	adenylate kinase activity
M1F28_RS07135	COG0200	Binds to the 23S rRNA
M1F28_RS07140	COG1841	ribosomal large subunit assembly
M1F28_RS07145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M1F28_RS07155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M1F28_RS07160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M1F28_RS07165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M1F28_RS07170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M1F28_RS07175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M1F28_RS07180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M1F28_RS07195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M1F28_RS07200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M1F28_RS07205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M1F28_RS07210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M1F28_RS07215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M1F28_RS07220	COG0089	rRNA binding
M1F28_RS07225	COG0088	Forms part of the polypeptide exit tunnel
M1F28_RS07230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M1F28_RS07235	COG0051	transcription antitermination factor activity, RNA binding
M1F28_RS07240	COG0546	phosphoglycolate phosphatase activity
M1F28_RS07250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M1F28_RS07255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M1F28_RS07260	COG0049	tRNA binding
M1F28_RS07265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M1F28_RS07270	COG0833	amino acid
M1F28_RS07275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M1F28_RS07280	COG0085	RNA polymerase activity
M1F28_RS07285	COG0222	ribosome binding
M1F28_RS07290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M1F28_RS07300	COG0081	regulation of translation
M1F28_RS07305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M1F28_RS07310	COG0250	Participates in transcription elongation, termination and antitermination
M1F28_RS07325	COG0436	Aminotransferase
M1F28_RS07335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1F28_RS07350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M1F28_RS07365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M1F28_RS07385	COG1666	GTP binding
M1F28_RS07395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M1F28_RS07400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M1F28_RS07405	COG5401	PFAM Sporulation and spore germination
M1F28_RS07410	COG5002	protein histidine kinase activity
M1F28_RS07410	COG5000	phosphorelay sensor kinase activity
M1F28_RS07415	COG0745	RESPONSE REGULATOR receiver
M1F28_RS07435	COG0714	Associated with various cellular activities
M1F28_RS07480	COG0483	inositol monophosphate 1-phosphatase activity
M1F28_RS07495	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M1F28_RS07520	COG0438	transferase activity, transferring glycosyl groups
M1F28_RS07520	COG1216	Glycosyl transferase, family 2
M1F28_RS07590	COG0673	inositol 2-dehydrogenase activity
M1F28_RS07615	COG1088	dTDP-glucose 4,6-dehydratase activity
M1F28_RS07630	COG1316	TRANSCRIPTIONal
M1F28_RS07635	COG1316	TRANSCRIPTIONal
M1F28_RS07645	COG0642	Histidine kinase
M1F28_RS07650	COG0745	RESPONSE REGULATOR receiver
M1F28_RS07665	COG0424	maF-like protein
M1F28_RS07700	COG1217	gtp-binding protein TYPA
M1F28_RS07710	COG1132	(ABC) transporter
M1F28_RS07740	COG0321	lipoyl(octanoyl) transferase activity
M1F28_RS07745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1F28_RS07755	COG1362	aminopeptidase activity
M1F28_RS07770	COG2838	Isocitrate dehydrogenase
M1F28_RS07775	COG2391	methyltransferase activity
M1F28_RS07780	COG0425	Belongs to the sulfur carrier protein TusA family
M1F28_RS07785	COG0366	Alpha amylase catalytic
M1F28_RS07790	COG1501	Belongs to the glycosyl hydrolase 31 family
M1F28_RS07800	COG0395	ABC-type sugar transport system, permease component
M1F28_RS07805	COG1175	transmembrane transport
M1F28_RS07810	COG1846	Transcriptional regulator
M1F28_RS07810	COG1940	carbohydrate kinase activity
M1F28_RS07835	COG4608	Belongs to the ABC transporter superfamily
M1F28_RS07840	COG0444	Belongs to the ABC transporter superfamily
M1F28_RS07845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1F28_RS07860	COG2116	formate transmembrane transporter activity
M1F28_RS07870	COG0242	peptide deformylase activity
M1F28_RS07875	COG1970	mechanosensitive ion channel activity
M1F28_RS07900	COG1846	Transcriptional regulator
M1F28_RS07900	COG0456	acetyltransferase
M1F28_RS07905	COG1780	Probably involved in ribonucleotide reductase function
M1F28_RS07915	COG0431	NADPH-dependent FMN reductase
M1F28_RS07920	COG3226	Transcriptional regulator
M1F28_RS07925	COG0477	Major facilitator Superfamily
M1F28_RS07935	COG1834	amidinotransferase
M1F28_RS07940	COG0549	Belongs to the carbamate kinase family
M1F28_RS07945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M1F28_RS07965	COG0395	ABC-type sugar transport system, permease component
M1F28_RS07980	COG0366	Alpha amylase catalytic
M1F28_RS07995	COG0477	Major facilitator Superfamily
M1F28_RS08025	COG1196	nuclear chromosome segregation
M1F28_RS08030	COG0012	GTP binding
M1F28_RS08035	COG1322	Protein conserved in bacteria
M1F28_RS08040	COG1162	GTPase activity
M1F28_RS08055	COG4555	ABC transporter
M1F28_RS08075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M1F28_RS08085	COG1722	exodeoxyribonuclease VII activity
M1F28_RS08090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1F28_RS08095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1F28_RS08105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M1F28_RS08110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1F28_RS08115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M1F28_RS08130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1F28_RS08135	COG1012	belongs to the aldehyde dehydrogenase family
M1F28_RS08150	COG1131	(ABC) transporter
M1F28_RS08155	COG1725	Transcriptional regulator
M1F28_RS08180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1F28_RS08200	COG0148	phosphopyruvate hydratase activity
M1F28_RS08215	COG0193	aminoacyl-tRNA hydrolase activity
M1F28_RS08220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M1F28_RS08230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M1F28_RS08240	COG1309	transcriptional regulator
M1F28_RS08255	COG4152	abc transporter atp-binding protein
M1F28_RS08260	COG1668	transmembrane transport
M1F28_RS08270	COG0488	(ABC) transporter
M1F28_RS08275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M1F28_RS08280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1F28_RS08290	COG0084	hydrolase, TatD family'
M1F28_RS08295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1F28_RS08300	COG1335	isochorismatase
M1F28_RS08320	COG2873	o-acetylhomoserine
M1F28_RS08340	COG1131	(ABC) transporter
M1F28_RS08355	COG2813	Specifically methylates the guanine in position
M1F28_RS08385	COG1620	l-lactate permease
M1F28_RS08390	COG0247	lactate metabolic process
M1F28_RS08400	COG1556	Lactate utilization protein
M1F28_RS08420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1F28_RS08425	COG2190	(PTS) system
M1F28_RS08430	COG1263	PTS System
M1F28_RS08430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M1F28_RS08450	COG1051	belongs to the nudix hydrolase family
M1F28_RS08460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1F28_RS08470	COG3711	transcriptional antiterminator
M1F28_RS08485	COG1511	domain protein
M1F28_RS08495	COG2848	UPF0210 protein
M1F28_RS08500	COG3830	Belongs to the UPF0237 family
M1F28_RS08515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M1F28_RS08520	COG0254	rRNA binding
M1F28_RS08525	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M1F28_RS08530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M1F28_RS08535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M1F28_RS08550	COG0477	Major facilitator Superfamily
M1F28_RS08555	COG0657	acetylesterase activity
M1F28_RS08560	COG2188	Transcriptional regulator
M1F28_RS08565	COG1120	ATPase activity
M1F28_RS08570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F28_RS08575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F28_RS08580	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M1F28_RS08595	COG0596	Alpha beta hydrolase
M1F28_RS08610	COG3657	addiction module killer protein
M1F28_RS08615	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1F28_RS08680	COG0791	NLP P60 protein
M1F28_RS08680	COG1388	LysM domain
M1F28_RS08690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M1F28_RS08695	COG2252	PERMEase
M1F28_RS08710	COG1278	Cold shock
M1F28_RS08720	COG1842	Phage shock protein A
M1F28_RS08730	COG0745	RESPONSE REGULATOR receiver
M1F28_RS08735	COG2205	protein histidine kinase activity
M1F28_RS08745	COG4221	oxidoreductase activity
M1F28_RS08760	COG0459	protein refolding
M1F28_RS08775	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M1F28_RS08810	COG3842	ATPase activity
M1F28_RS08820	COG0673	inositol 2-dehydrogenase activity
M1F28_RS08830	COG1653	transport
M1F28_RS08835	COG1175	transmembrane transport
M1F28_RS08865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1F28_RS08880	COG1966	Carbon starvation protein
M1F28_RS08905	COG2233	PERMEase
M1F28_RS08920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1F28_RS08925	COG0215	cysteine-tRNA ligase activity
M1F28_RS08935	COG1136	(ABC) transporter
M1F28_RS08950	COG2376	Dihydroxyacetone kinase
M1F28_RS08965	COG3775	system Galactitol-specific IIC component
M1F28_RS08995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M1F28_RS09000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M1F28_RS09015	COG5002	protein histidine kinase activity
M1F28_RS09025	COG0588	phosphoglycerate mutase activity
M1F28_RS09070	COG1120	ATPase activity
M1F28_RS09075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F28_RS09105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M1F28_RS09110	COG0667	Aldo Keto reductase
M1F28_RS09120	COG0710	3-dehydroquinate dehydratase activity
M1F28_RS09150	COG0714	Associated with various cellular activities
M1F28_RS09165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M1F28_RS09170	COG1950	PFAM Membrane protein of
M1F28_RS09175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1F28_RS09180	COG0586	Pfam SNARE associated Golgi protein
M1F28_RS09215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1F28_RS09220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F28_RS09225	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F28_RS09230	COG1120	ATPase activity
M1F28_RS09245	COG1063	alcohol dehydrogenase
M1F28_RS09250	COG1609	Transcriptional regulator
M1F28_RS09255	COG2271	Major facilitator Superfamily
M1F28_RS09260	COG0483	inositol monophosphate 1-phosphatase activity
M1F28_RS09265	COG1879	ABC-type sugar transport system periplasmic component
M1F28_RS09270	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1F28_RS09280	COG0673	inositol 2-dehydrogenase activity
M1F28_RS09290	COG0673	inositol 2-dehydrogenase activity
M1F28_RS09295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1F28_RS09315	COG3718	enzyme involved in inositol metabolism
M1F28_RS09320	COG3962	Belongs to the TPP enzyme family
M1F28_RS09330	COG4604	ABC transporter, ATP-binding protein
M1F28_RS09335	COG4605	iron ion homeostasis
M1F28_RS09340	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1F28_RS09345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M1F28_RS09350	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M1F28_RS09360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M1F28_RS09360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M1F28_RS09365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M1F28_RS09370	COG1904	glucuronate isomerase
M1F28_RS09385	COG3142	Participates in the control of copper homeostasis
M1F28_RS09400	COG1940	carbohydrate kinase activity
M1F28_RS09410	COG0601	transmembrane transport
M1F28_RS09415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1F28_RS09425	COG1940	carbohydrate kinase activity
M1F28_RS09430	COG1940	carbohydrate kinase activity
M1F28_RS09430	COG1846	Transcriptional regulator
M1F28_RS09440	COG1175	transmembrane transport
M1F28_RS09470	COG1132	(ABC) transporter
M1F28_RS09475	COG2375	cellular response to nickel ion
M1F28_RS09475	COG1132	(ABC) transporter
M1F28_RS09480	COG1129	ABC transporter
M1F28_RS09485	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M1F28_RS09500	COG0471	metal ion transport
M1F28_RS09515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1F28_RS09560	COG3415	Transposase
M1F28_RS09560	COG2801	Transposase and inactivated derivatives
M1F28_RS09600	COG1172	Belongs to the binding-protein-dependent transport system permease family
M1F28_RS09610	COG1879	ABC-type sugar transport system periplasmic component
M1F28_RS09620	COG1070	Carbohydrate kinase
M1F28_RS09645	COG1252	NADH dehydrogenase
M1F28_RS09665	COG1518	maintenance of DNA repeat elements
M1F28_RS09725	COG1643	Atp-dependent helicase
M1F28_RS09740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1F28_RS09770	COG0577	efflux transmembrane transporter activity
M1F28_RS09770	COG1136	(ABC) transporter
M1F28_RS09775	COG1136	(ABC) transporter
M1F28_RS09790	COG0745	RESPONSE REGULATOR receiver
M1F28_RS09795	COG2205	protein histidine kinase activity
M1F28_RS09800	COG0343	queuine tRNA-ribosyltransferase activity
M1F28_RS09810	COG1428	Deoxynucleoside kinase
M1F28_RS09850	COG0656	L-ascorbic acid biosynthetic process
M1F28_RS09855	COG0351	phosphomethylpyrimidine kinase
M1F28_RS09865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1F28_RS09875	COG2814	Major facilitator Superfamily
M1F28_RS09880	COG0305	Participates in initiation and elongation during chromosome replication
M1F28_RS09905	COG0359	binds to the 23S rRNA
M1F28_RS09910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M1F28_RS09920	COG0360	Binds together with S18 to 16S ribosomal RNA
M1F28_RS09925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1F28_RS09930	COG0628	permease
M1F28_RS09940	COG0617	tRNA 3'-terminal CCA addition
M1F28_RS09960	COG0492	ferredoxin-NADP+ reductase activity
M1F28_RS09965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1F28_RS09970	COG1181	Belongs to the D-alanine--D-alanine ligase family
M1F28_RS09980	COG1192	Involved in chromosome partitioning
M1F28_RS09985	COG0357	Ribosomal RNA small subunit methyltransferase G
M1F28_RS09995	COG0706	membrane insertase activity
M1F28_RS10000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M1F28_RS10005	COG0594	ribonuclease P activity
M1F28_RS10010	COG0230	Belongs to the bacterial ribosomal protein bL34 family