locus-tag	class	description
X956_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
X956_RS00055	COG0187	DNA topoisomerase II activity
X956_RS00065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
X956_RS00070	COG0592	DNA-directed DNA polymerase activity
X956_RS00075	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
X956_RS00080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
X956_RS00085	COG0594	ribonuclease P activity
X956_RS00090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
X956_RS00095	COG0706	membrane insertase activity
X956_RS00110	COG1192	Involved in chromosome partitioning
X956_RS00120	COG1181	Belongs to the D-alanine--D-alanine ligase family
X956_RS00125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X956_RS00130	COG0492	ferredoxin-NADP+ reductase activity
X956_RS00160	COG0359	binds to the 23S rRNA
X956_RS00165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
X956_RS00175	COG0360	Binds together with S18 to 16S ribosomal RNA
X956_RS00180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X956_RS00185	COG0628	permease
X956_RS00195	COG0617	tRNA 3'-terminal CCA addition
X956_RS00210	COG2814	Major facilitator Superfamily
X956_RS00215	COG0305	Participates in initiation and elongation during chromosome replication
X956_RS00230	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
X956_RS00245	COG0351	phosphomethylpyrimidine kinase
X956_RS00290	COG1428	Deoxynucleoside kinase
X956_RS00300	COG0343	queuine tRNA-ribosyltransferase activity
X956_RS00305	COG0745	RESPONSE REGULATOR receiver
X956_RS00315	COG0577	efflux transmembrane transporter activity
X956_RS00345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
X956_RS00360	COG1643	Atp-dependent helicase
X956_RS00365	COG1609	Transcriptional regulator
X956_RS00370	COG2271	Major facilitator Superfamily
X956_RS00375	COG1285	pathogenesis
X956_RS00400	COG1131	(ABC) transporter
X956_RS00420	COG1172	Belongs to the binding-protein-dependent transport system permease family
X956_RS00430	COG1879	ABC-type sugar transport system periplasmic component
X956_RS00440	COG1070	Carbohydrate kinase
X956_RS00460	COG1252	NADH dehydrogenase
X956_RS00465	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
X956_RS00505	COG0471	metal ion transport
X956_RS00520	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
X956_RS00525	COG1129	ABC transporter
X956_RS00530	COG2375	cellular response to nickel ion
X956_RS00530	COG1132	(ABC) transporter
X956_RS00535	COG1132	(ABC) transporter
X956_RS00610	COG1175	transmembrane transport
X956_RS00635	COG1940	carbohydrate kinase activity
X956_RS00645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X956_RS00650	COG0601	transmembrane transport
X956_RS00660	COG1940	carbohydrate kinase activity
X956_RS00675	COG3142	Participates in the control of copper homeostasis
X956_RS00690	COG1904	glucuronate isomerase
X956_RS00695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
X956_RS00700	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
X956_RS00700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
X956_RS00710	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
X956_RS00715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X956_RS00720	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X956_RS00725	COG4605	iron ion homeostasis
X956_RS00730	COG4604	ABC transporter, ATP-binding protein
X956_RS00740	COG3962	Belongs to the TPP enzyme family
X956_RS00745	COG3718	enzyme involved in inositol metabolism
X956_RS00765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
X956_RS00770	COG0673	inositol 2-dehydrogenase activity
X956_RS00780	COG0673	inositol 2-dehydrogenase activity
X956_RS00790	COG1172	Belongs to the binding-protein-dependent transport system permease family
X956_RS00795	COG1879	ABC-type sugar transport system periplasmic component
X956_RS00800	COG0483	inositol monophosphate 1-phosphatase activity
X956_RS00805	COG2271	Major facilitator Superfamily
X956_RS00815	COG1063	alcohol dehydrogenase
X956_RS00830	COG1129	ABC transporter
X956_RS00835	COG2375	cellular response to nickel ion
X956_RS00835	COG1132	(ABC) transporter
X956_RS00845	COG1309	transcriptional regulator
X956_RS00890	COG0586	Pfam SNARE associated Golgi protein
X956_RS00895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
X956_RS00900	COG1950	PFAM Membrane protein of
X956_RS00905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X956_RS00920	COG0710	3-dehydroquinate dehydratase activity
X956_RS00930	COG0667	Aldo Keto reductase
X956_RS00935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
X956_RS00965	COG1175	transmembrane transport
X956_RS00970	COG0395	ABC-type sugar transport system, permease component
X956_RS00980	COG3345	alpha-galactosidase
X956_RS01000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X956_RS01005	COG1120	ATPase activity
X956_RS01050	COG0588	phosphoglycerate mutase activity
X956_RS01060	COG5002	protein histidine kinase activity
X956_RS01075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
X956_RS01080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
X956_RS01100	COG2376	Dihydroxyacetone kinase
X956_RS01115	COG3775	system Galactitol-specific IIC component
X956_RS01130	COG2376	Dihydroxyacetone kinase
X956_RS01145	COG1136	(ABC) transporter
X956_RS01155	COG0215	cysteine-tRNA ligase activity
X956_RS01160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X956_RS01175	COG2233	PERMEase
X956_RS01195	COG1966	Carbon starvation protein
X956_RS01210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
X956_RS01245	COG1175	transmembrane transport
X956_RS01250	COG1653	transport
X956_RS01260	COG0673	inositol 2-dehydrogenase activity
X956_RS01270	COG3842	ATPase activity
X956_RS01310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
X956_RS01325	COG0459	protein refolding
X956_RS01335	COG4221	oxidoreductase activity
X956_RS01345	COG2205	protein histidine kinase activity
X956_RS01350	COG0745	RESPONSE REGULATOR receiver
X956_RS01360	COG1842	Phage shock protein A
X956_RS01370	COG1278	Cold shock
X956_RS01385	COG2252	PERMEase
X956_RS01390	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
X956_RS01400	COG0791	NLP P60 protein
X956_RS01400	COG1388	LysM domain
X956_RS01460	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
X956_RS01465	COG3657	addiction module killer protein
X956_RS01480	COG0596	Alpha beta hydrolase
X956_RS01495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
X956_RS01500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X956_RS01505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X956_RS01510	COG1120	ATPase activity
X956_RS01515	COG2188	Transcriptional regulator
X956_RS01520	COG0657	acetylesterase activity
X956_RS01525	COG0477	Major facilitator Superfamily
X956_RS01540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
X956_RS01545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
X956_RS01550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
X956_RS01555	COG0254	rRNA binding
X956_RS01560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
X956_RS01575	COG3830	Belongs to the UPF0237 family
X956_RS01580	COG2848	UPF0210 protein
X956_RS01590	COG1511	domain protein
X956_RS01605	COG3711	transcriptional antiterminator
X956_RS01615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
X956_RS01625	COG1051	belongs to the nudix hydrolase family
X956_RS01640	COG1263	PTS System
X956_RS01640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X956_RS01645	COG2190	(PTS) system
X956_RS01650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
X956_RS01670	COG1556	Lactate utilization protein
X956_RS01680	COG0247	lactate metabolic process
X956_RS01685	COG1620	l-lactate permease
X956_RS01710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X956_RS01715	COG2813	Specifically methylates the guanine in position
X956_RS01730	COG1131	(ABC) transporter
X956_RS01745	COG2873	o-acetylhomoserine
X956_RS01765	COG1335	isochorismatase
X956_RS01795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
X956_RS01800	COG0084	hydrolase, TatD family'
X956_RS01810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
X956_RS01815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
X956_RS01820	COG0488	(ABC) transporter
X956_RS01830	COG1668	transmembrane transport
X956_RS01835	COG4152	abc transporter atp-binding protein
X956_RS01850	COG1309	transcriptional regulator
X956_RS01860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
X956_RS01870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
X956_RS01875	COG0193	aminoacyl-tRNA hydrolase activity
X956_RS01890	COG0148	phosphopyruvate hydratase activity
X956_RS01910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
X956_RS01935	COG1725	Transcriptional regulator
X956_RS01940	COG1131	(ABC) transporter
X956_RS01955	COG1012	belongs to the aldehyde dehydrogenase family
X956_RS01960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X956_RS01975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X956_RS01980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X956_RS01985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
X956_RS01995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
X956_RS02000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X956_RS02005	COG1722	exodeoxyribonuclease VII activity
X956_RS02015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
X956_RS02025	COG4555	ABC transporter
X956_RS02040	COG1162	GTPase activity
X956_RS02045	COG1322	Protein conserved in bacteria
X956_RS02050	COG0012	GTP binding
X956_RS02075	COG0477	Major facilitator Superfamily
X956_RS02090	COG0366	Alpha amylase catalytic
X956_RS02105	COG0395	ABC-type sugar transport system, permease component
X956_RS02125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
X956_RS02130	COG0549	Belongs to the carbamate kinase family
X956_RS02135	COG1834	amidinotransferase
X956_RS02145	COG0477	Major facilitator Superfamily
X956_RS02150	COG3226	Transcriptional regulator
X956_RS02155	COG0431	NADPH-dependent FMN reductase
X956_RS02165	COG1780	Probably involved in ribonucleotide reductase function
X956_RS02190	COG1970	mechanosensitive ion channel activity
X956_RS02195	COG0242	peptide deformylase activity
X956_RS02205	COG2116	formate transmembrane transporter activity
X956_RS02220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X956_RS02225	COG0444	Belongs to the ABC transporter superfamily
X956_RS02230	COG4608	Belongs to the ABC transporter superfamily
X956_RS02265	COG1840	ABC-type Fe3 transport system, periplasmic component
X956_RS02270	COG3842	ATPase activity
X956_RS02275	COG1178	ABC-type Fe3 transport system permease component
X956_RS02305	COG1846	Transcriptional regulator
X956_RS02305	COG1940	carbohydrate kinase activity
X956_RS02310	COG1175	transmembrane transport
X956_RS02315	COG0395	ABC-type sugar transport system, permease component
X956_RS02325	COG1501	Belongs to the glycosyl hydrolase 31 family
X956_RS02330	COG0366	Alpha amylase catalytic
X956_RS02335	COG0425	Belongs to the sulfur carrier protein TusA family
X956_RS02340	COG2391	methyltransferase activity
X956_RS02345	COG2838	Isocitrate dehydrogenase
X956_RS02390	COG0321	lipoyl(octanoyl) transferase activity
X956_RS02395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
X956_RS02405	COG1362	aminopeptidase activity
X956_RS02415	COG1132	(ABC) transporter
X956_RS02425	COG1217	gtp-binding protein TYPA
X956_RS02460	COG0424	maF-like protein
X956_RS02475	COG0745	RESPONSE REGULATOR receiver
X956_RS02490	COG1316	TRANSCRIPTIONal
X956_RS02495	COG1316	TRANSCRIPTIONal
X956_RS02510	COG1088	dTDP-glucose 4,6-dehydratase activity
X956_RS02535	COG0673	inositol 2-dehydrogenase activity
X956_RS02585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
X956_RS02630	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
X956_RS02645	COG0483	inositol monophosphate 1-phosphatase activity
X956_RS02695	COG0714	Associated with various cellular activities
X956_RS02715	COG0745	RESPONSE REGULATOR receiver
X956_RS02720	COG5000	phosphorelay sensor kinase activity
X956_RS02720	COG5002	protein histidine kinase activity
X956_RS02735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
X956_RS02740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
X956_RS02750	COG1666	GTP binding
X956_RS02770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
X956_RS02785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
X956_RS02800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
X956_RS02810	COG0436	Aminotransferase
X956_RS02825	COG0250	Participates in transcription elongation, termination and antitermination
X956_RS02830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
X956_RS02835	COG0081	regulation of translation
X956_RS02850	COG0572	uridine kinase
X956_RS02855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
X956_RS02860	COG0222	ribosome binding
X956_RS02865	COG0085	RNA polymerase activity
X956_RS02870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
X956_RS02890	COG0833	amino acid
X956_RS02895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
X956_RS02900	COG0049	tRNA binding
X956_RS02905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
X956_RS02910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
X956_RS02925	COG0051	transcription antitermination factor activity, RNA binding
X956_RS02930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
X956_RS02935	COG0088	Forms part of the polypeptide exit tunnel
X956_RS02940	COG0089	rRNA binding
X956_RS02945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
X956_RS02950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
X956_RS02955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
X956_RS02960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
X956_RS02965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
X956_RS02980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
X956_RS02985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
X956_RS02990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
X956_RS02995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
X956_RS03000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
X956_RS03005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
X956_RS03015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
X956_RS03020	COG1841	ribosomal large subunit assembly
X956_RS03025	COG0200	Binds to the 23S rRNA
X956_RS03035	COG0563	adenylate kinase activity
X956_RS03045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
X956_RS03050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
X956_RS03060	COG0202	RNA polymerase activity
X956_RS03065	COG0203	ribosomal protein L17
X956_RS03070	COG1666	GTP binding
X956_RS03075	COG0789	Transcriptional regulator
X956_RS03080	COG4598	ABC transporter
X956_RS03085	COG0765	amino acid transport
X956_RS03095	COG1940	carbohydrate kinase activity
X956_RS03100	COG0101	tRNA pseudouridine synthase activity
X956_RS03120	COG1122	ATPase activity
X956_RS03125	COG4720	Psort location CytoplasmicMembrane, score
X956_RS03135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
X956_RS03140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
X956_RS03150	COG1072	(Pantothenic acid kinase))
X956_RS03155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
X956_RS03165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
X956_RS03170	COG0802	atpase or kinase
X956_RS03195	COG1053	succinate dehydrogenase
X956_RS03200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
X956_RS03205	COG0733	neurotransmitter:sodium symporter activity
X956_RS03210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
X956_RS03215	COG0428	transporter
X956_RS03225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
X956_RS03235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
X956_RS03240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
X956_RS03245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
X956_RS03250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
X956_RS03255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
X956_RS03260	COG0151	Belongs to the GarS family
X956_RS03265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X956_RS03285	COG0516	GMP reductase activity
X956_RS03300	COG0516	GMP reductase activity
X956_RS03305	COG0114	fumarate hydratase activity
X956_RS03315	COG1136	(ABC) transporter
X956_RS03330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
X956_RS03335	COG0857	belongs to the CobB CobQ family
X956_RS03335	COG0280	phosphate acetyltransferase
X956_RS03385	COG0542	response to heat
X956_RS03405	COG0653	protein targeting
X956_RS03415	COG2755	lipolytic protein G-D-S-L family
X956_RS03415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
X956_RS03420	COG0045	succinate-CoA ligase (ADP-forming) activity
X956_RS03440	COG0138	bifunctional purine biosynthesis protein purh
X956_RS03450	COG0205	6-phosphofructokinase activity
X956_RS03455	COG0166	Belongs to the GPI family
X956_RS03465	COG0039	L-malate dehydrogenase activity
X956_RS03475	COG0110	maltose O-acetyltransferase activity
X956_RS03505	COG2030	dehydratase
X956_RS03510	COG2271	Major facilitator Superfamily
X956_RS03515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X956_RS03530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
X956_RS03535	COG0644	oxidoreductase
X956_RS03565	COG1268	BioY protein
X956_RS03575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
X956_RS03580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
X956_RS03585	COG4770	biotin carboxylase activity
X956_RS03595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
X956_RS03600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
X956_RS03615	COG0662	Cupin 2, conserved barrel domain protein
X956_RS03615	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
X956_RS03620	COG1744	ABC transporter substrate-binding protein PnrA-like
X956_RS03625	COG3845	ABC transporter
X956_RS03630	COG4603	Belongs to the binding-protein-dependent transport system permease family
X956_RS03635	COG1079	Belongs to the binding-protein-dependent transport system permease family
X956_RS03655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
X956_RS03660	COG2814	Major facilitator Superfamily
X956_RS03670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
X956_RS03680	COG1611	Belongs to the LOG family
X956_RS03700	COG2239	Acts as a magnesium transporter
X956_RS03705	COG0006	proline dipeptidase activity
X956_RS03715	COG2095	MarC family integral membrane protein
X956_RS03720	COG0513	Belongs to the DEAD box helicase family
X956_RS03780	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
X956_RS03785	COG2884	Cell division ATP-binding protein ftsE
X956_RS03790	COG2177	Part of the ABC transporter FtsEX involved in
X956_RS03810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
X956_RS04065	COG1619	proteins homologs of microcin C7 resistance protein MccF
X956_RS04080	COG0739	heme binding
X956_RS04100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
X956_RS04115	COG0569	domain protein
X956_RS04115	COG2985	domain, Protein
X956_RS04140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
X956_RS04150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
X956_RS04160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
X956_RS04165	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
X956_RS04190	COG1022	Amp-dependent synthetase and ligase
X956_RS04195	COG0179	Fumarylacetoacetate (FAA) hydrolase
X956_RS04250	COG0339	signal peptide processing
X956_RS04255	COG4975	Glucose uptake
X956_RS04265	COG0438	transferase activity, transferring glycosyl groups
X956_RS04285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
X956_RS04290	COG1181	Belongs to the D-alanine--D-alanine ligase family
X956_RS04300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
X956_RS04310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
X956_RS04325	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
X956_RS04340	COG0571	ribonuclease III activity
X956_RS04345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
X956_RS04365	COG1132	(ABC) transporter
X956_RS04370	COG1132	(ABC) transporter
X956_RS04380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
X956_RS04385	COG4988	ABC transporter
X956_RS04390	COG1294	oxidase, subunit
X956_RS04395	COG1271	oxidase subunit
X956_RS04400	COG1530	ribonuclease E activity
X956_RS04405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
X956_RS04415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
X956_RS04425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X956_RS04430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
X956_RS04440	COG0799	negative regulation of ribosome biogenesis
X956_RS04480	COG0235	Class ii aldolase
X956_RS04485	COG0738	Major facilitator superfamily
X956_RS04495	COG1609	Transcriptional regulator
X956_RS04500	COG0133	tryptophan synthase activity
X956_RS04505	COG0726	polysaccharide deacetylase
X956_RS04550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X956_RS04565	COG0826	peptidase U32
X956_RS04570	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
X956_RS04580	COG1113	amino acid transport
X956_RS04585	COG1464	Belongs to the NlpA lipoprotein family
X956_RS04590	COG2011	ABC-type metal ion transport system permease component
X956_RS04600	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
X956_RS04600	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
X956_RS04605	COG1113	amino acid transport
X956_RS04620	COG1395	domain, Protein
X956_RS04630	COG0671	phosphoesterase, PA-phosphatase related
X956_RS04645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X956_RS04650	COG1121	(ABC) transporter
X956_RS04660	COG0803	Belongs to the bacterial solute-binding protein 9 family
X956_RS04680	COG1435	thymidine kinase activity
X956_RS04690	COG0813	purine-nucleoside phosphorylase activity
X956_RS04715	COG0495	leucyl-tRNA aminoacylation
X956_RS04750	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
X956_RS04755	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
X956_RS04760	COG0268	Binds directly to 16S ribosomal RNA
X956_RS04785	COG0481	GTPase activity
X956_RS04790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
X956_RS04810	COG1420	regulation of RNA biosynthetic process
X956_RS04815	COG0484	heat shock protein binding
X956_RS04820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
X956_RS04830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
X956_RS04865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X956_RS04870	COG1381	Involved in DNA repair and RecF pathway recombination
X956_RS04875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
X956_RS04890	COG0131	Imidazoleglycerol-phosphate dehydratase
X956_RS04900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
X956_RS04905	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
X956_RS04915	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
X956_RS04920	COG0291	Belongs to the bacterial ribosomal protein bL35 family
X956_RS04935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X956_RS04955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
X956_RS04960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
X956_RS04975	COG1438	arginine binding
X956_RS04980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
X956_RS04990	COG1476	TRANSCRIPTIONal
X956_RS05000	COG1131	(ABC) transporter
X956_RS05005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
X956_RS05010	COG0803	Belongs to the bacterial solute-binding protein 9 family
X956_RS05015	COG1121	(ABC) transporter
X956_RS05020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X956_RS05025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X956_RS05050	COG0647	UMP catabolic process
X956_RS05060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
X956_RS05065	COG0497	DNA recombination
X956_RS05085	COG0728	peptidoglycan biosynthetic process
X956_RS05115	COG0396	ATPase activity
X956_RS05130	COG2151	metal-sulfur cluster biosynthetic enzyme
X956_RS05135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X956_RS05140	COG0488	(ABC) transporter
X956_RS05150	COG3830	Belongs to the UPF0237 family
X956_RS05150	COG0560	Phosphoserine phosphatase
X956_RS05165	COG0297	glycogen (starch) synthase activity
X956_RS05170	COG1119	ATPase activity
X956_RS05220	COG1881	PFAM PEBP family protein
X956_RS05235	COG0587	DNA-directed DNA polymerase activity
X956_RS05260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
X956_RS05260	COG0519	Catalyzes the synthesis of GMP from XMP
X956_RS05270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X956_RS05285	COG1968	undecaprenyl-diphosphatase activity
X956_RS05305	COG1222	aaa ATPase
X956_RS05310	COG4122	O-methyltransferase activity
X956_RS05320	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
X956_RS05350	COG0205	6-phosphofructokinase activity
X956_RS05355	COG1160	GTP binding
X956_RS05370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
X956_RS05395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
X956_RS05410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
X956_RS05415	COG0149	triose-phosphate isomerase activity
X956_RS05420	COG0126	phosphoglycerate kinase activity
X956_RS05425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
X956_RS05430	COG1481	regulation of sporulation
X956_RS05440	COG1660	Displays ATPase and GTPase activities
X956_RS05445	COG0322	excinuclease ABC activity
X956_RS05470	COG0556	nucleotide-excision repair
X956_RS05480	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
X956_RS05485	COG1136	(ABC) transporter
X956_RS05520	COG0469	pyruvate kinase activity
X956_RS05525	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
X956_RS05530	COG0134	indole-3-glycerol-phosphate synthase activity
X956_RS05570	COG1216	Glycosyl transferase, family 2
X956_RS05580	COG4581	dead DEAH box helicase
X956_RS05610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
X956_RS05615	COG0140	phosphoribosyl-ATP diphosphatase activity
X956_RS05620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X956_RS05625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X956_RS05630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
X956_RS05640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
X956_RS05645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
X956_RS05650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
X956_RS05660	COG1758	RNA polymerase activity
X956_RS05665	COG0194	GDP metabolic process
X956_RS05680	COG0505	Belongs to the CarA family
X956_RS05685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X956_RS05690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
X956_RS05695	COG2217	Heavy metal translocating P-type atpase
X956_RS05700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
X956_RS05710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
X956_RS05730	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
X956_RS05735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
X956_RS05750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
X956_RS05760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
X956_RS05765	COG2409	Drug exporters of the RND superfamily
X956_RS05780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
X956_RS05800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
X956_RS05805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
X956_RS05810	COG0124	histidyl-tRNA synthetase
X956_RS05815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X956_RS05820	COG1196	nuclear chromosome segregation
X956_RS05830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X956_RS05835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
X956_RS05840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X956_RS05845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X956_RS05855	COG2255	four-way junction helicase activity
X956_RS05860	COG0632	four-way junction helicase activity
X956_RS05865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
X956_RS05870	COG0217	transcriptional regulatory protein
X956_RS05875	COG1051	belongs to the nudix hydrolase family
X956_RS05885	COG0438	transferase activity, transferring glycosyl groups
X956_RS05895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
X956_RS05900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
X956_RS05905	COG1760	l-serine dehydratase
X956_RS05910	COG2197	response regulator
X956_RS05975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
X956_RS05985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
X956_RS06000	COG0569	domain protein
X956_RS06045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
X956_RS06060	COG0187	DNA topoisomerase II activity
X956_RS06070	COG1199	ATP-dependent helicase activity
X956_RS06070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
X956_RS06075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
X956_RS06090	COG0142	geranyltranstransferase activity
X956_RS06105	COG0515	serine threonine protein kinase
X956_RS06105	COG2815	serine threonine protein kinase
X956_RS06110	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
X956_RS06115	COG0205	6-phosphofructokinase activity
X956_RS06155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
X956_RS06175	COG0508	dehydrogenase complex catalyzes the overall conversion of
X956_RS06180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X956_RS06190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
X956_RS06215	COG0174	glutamine synthetase
X956_RS06225	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
X956_RS06230	COG0174	glutamine synthetase
X956_RS06245	COG1940	carbohydrate kinase activity
X956_RS06260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
X956_RS06265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
X956_RS06270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
X956_RS06295	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
X956_RS06315	COG0009	L-threonylcarbamoyladenylate synthase
X956_RS06335	COG1090	epimerase
X956_RS06370	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
X956_RS06375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X956_RS06410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
X956_RS06415	COG0805	protein transport
X956_RS06425	COG0358	DNA primase activity
X956_RS06450	COG0423	glycine-tRNA ligase activity
X956_RS06460	COG1121	(ABC) transporter
X956_RS06465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X956_RS06470	COG0735	belongs to the Fur family
X956_RS06485	COG0587	DNA-directed DNA polymerase activity
X956_RS06500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
X956_RS06515	COG1799	cell septum assembly
X956_RS06525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
X956_RS06535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
X956_RS06540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
X956_RS06545	COG0772	Belongs to the SEDS family
X956_RS06550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
X956_RS06555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X956_RS06560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
X956_RS06565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
X956_RS06570	COG0768	penicillin binding
X956_RS06580	COG0275	rRNA processing
X956_RS06585	COG2001	Belongs to the MraZ family
X956_RS06595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
X956_RS06615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X956_RS06620	COG0318	PFAM AMP-dependent synthetase and ligase
X956_RS06625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
X956_RS06635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
X956_RS06645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
X956_RS06655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
X956_RS06660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
X956_RS06665	COG2137	regulation of response to DNA damage stimulus
X956_RS06670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
X956_RS06680	COG1396	sequence-specific DNA binding
X956_RS06685	COG1058	Belongs to the CinA family
X956_RS06685	COG1546	Belongs to the CinA family
X956_RS06700	COG1674	ftsk spoiiie
X956_RS06710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
X956_RS06730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
X956_RS06735	COG0612	Peptidase, M16
X956_RS06745	COG1185	polyribonucleotide nucleotidyltransferase activity
X956_RS06770	COG0196	riboflavin kinase activity
X956_RS06775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
X956_RS06780	COG3852	Histidine kinase
X956_RS06785	COG0745	RESPONSE REGULATOR receiver
X956_RS06790	COG2271	Major facilitator Superfamily
X956_RS06800	COG3842	ATPase activity
X956_RS06825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
X956_RS06830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
X956_RS06835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
X956_RS06850	COG0779	Required for maturation of 30S ribosomal subunits
X956_RS06860	COG0442	prolyl-tRNA aminoacylation
X956_RS06870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
X956_RS06875	COG0750	zinc metalloprotease
X956_RS06880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
X956_RS06890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
X956_RS06900	COG0233	cytoplasmic translational termination
X956_RS06925	COG0644	oxidoreductase
X956_RS06930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
X956_RS06940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
X956_RS06945	COG0052	Belongs to the universal ribosomal protein uS2 family
X956_RS06950	COG2860	membrane
X956_RS06955	COG4942	peptidase
X956_RS06955	COG1388	LysM domain
X956_RS06960	COG4974	Belongs to the 'phage' integrase family
X956_RS06985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
X956_RS06990	COG0681	Belongs to the peptidase S26 family
X956_RS06995	COG0335	large ribosomal subunit rRNA binding
X956_RS07005	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
X956_RS07010	COG1837	Belongs to the UPF0109 family
X956_RS07015	COG0228	four-way junction DNA binding
X956_RS07020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
X956_RS07060	COG0105	UTP biosynthetic process
X956_RS07065	COG0285	dihydrofolate synthase activity
X956_RS07070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
X956_RS07085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
X956_RS07105	COG1605	Chorismate mutase
X956_RS07105	COG0287	Prephenate dehydrogenase
X956_RS07110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
X956_RS07115	COG0740	serine-type endopeptidase activity
X956_RS07120	COG0740	serine-type endopeptidase activity
X956_RS07125	COG0544	peptidyl-prolyl cis-trans isomerase activity
X956_RS07130	COG0667	Aldo Keto reductase
X956_RS07150	COG3250	beta-galactosidase activity
X956_RS07155	COG1609	Transcriptional regulator
X956_RS07170	COG0488	(ABC) transporter
X956_RS07185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X956_RS07200	COG1739	Uncharacterized protein family UPF0029
X956_RS07210	COG1045	serine acetyltransferase
X956_RS07230	COG3590	peptidase
X956_RS07235	COG2354	Protein conserved in bacteria
X956_RS07245	COG0519	Catalyzes the synthesis of GMP from XMP
X956_RS07260	COG1946	Acyl-CoA thioesterase
X956_RS07290	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
X956_RS07330	COG0438	transferase activity, transferring glycosyl groups
X956_RS07335	COG4750	Nucleotidyl transferase
X956_RS07340	COG3475	LICD family
X956_RS07345	COG1216	Glycosyl transferase, family 2
X956_RS07345	COG1442	glycosyl transferase family 8
X956_RS07370	COG2244	polysaccharide biosynthetic process
X956_RS07375	COG0463	Glycosyl transferase, family 2
X956_RS07405	COG1882	Formate acetyltransferase
X956_RS07410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
X956_RS07425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
X956_RS07430	COG0440	acetolactate synthase activity
X956_RS07440	COG2985	domain, Protein
X956_RS07440	COG0569	domain protein
X956_RS07445	COG0129	dihydroxy-acid dehydratase activity
X956_RS07460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
X956_RS07465	COG0154	amidase activity
X956_RS07470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
X956_RS07475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X956_RS07490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X956_RS07500	COG1397	ADP-ribosylglycohydrolase
X956_RS07510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
X956_RS07515	COG2135	peptidase activity
X956_RS07520	COG4585	Histidine kinase
X956_RS07555	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
X956_RS07565	COG1053	succinate dehydrogenase
X956_RS07595	COG0387	Pfam Sodium calcium exchanger
X956_RS07605	COG1131	(ABC) transporter
X956_RS07610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X956_RS07635	COG1615	UPF0182 protein
X956_RS07645	COG3480	Lon protease (S16) C-terminal proteolytic domain
X956_RS07675	COG0180	Tryptophanyl-tRNA synthetase
X956_RS07680	COG0058	SHG alpha-glucan phosphorylase activity
X956_RS07685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
X956_RS07710	COG0366	Alpha amylase catalytic
X956_RS07715	COG0366	Alpha amylase catalytic
X956_RS07720	COG3281	Trehalose synthase
X956_RS07725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
X956_RS07735	COG3833	ABC-type maltose transport systems, permease component
X956_RS07740	COG1175	transmembrane transport
X956_RS07750	COG1609	Transcriptional regulator
X956_RS07795	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
X956_RS07805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
X956_RS07810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
X956_RS07815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
X956_RS07820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
X956_RS07825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
X956_RS07830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
X956_RS07835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
X956_RS07840	COG0356	it plays a direct role in the translocation of protons across the membrane
X956_RS07860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
X956_RS07875	COG0083	homoserine kinase activity
X956_RS07880	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
X956_RS07885	COG0460	homoserine dehydrogenase
X956_RS07895	COG0018	arginyl-trna synthetase
X956_RS07930	COG0584	glycerophosphoryl diester phosphodiesterase
X956_RS07945	COG1253	flavin adenine dinucleotide binding
X956_RS07950	COG0508	dehydrogenase complex catalyzes the overall conversion of
X956_RS07950	COG0567	Dehydrogenase, E1 component
X956_RS07960	COG0791	NLP P60 protein
X956_RS07960	COG1388	LysM domain
X956_RS07960	COG3103	Sh3 type 3 domain protein
X956_RS07970	COG1595	DNA-templated transcription, initiation
X956_RS07980	COG0363	glucosamine-6-phosphate deaminase activity
X956_RS07985	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
X956_RS08020	COG0601	transmembrane transport
X956_RS08025	COG0444	Belongs to the ABC transporter superfamily
X956_RS08030	COG4608	Belongs to the ABC transporter superfamily
X956_RS08035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X956_RS08045	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
X956_RS08055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X956_RS08060	COG1162	GTPase activity
X956_RS08065	COG0483	inositol monophosphate 1-phosphatase activity
X956_RS08070	COG0420	3'-5' exonuclease activity
X956_RS08075	COG0419	ATPase involved in DNA repair
X956_RS08115	COG0653	protein targeting
X956_RS08120	COG0142	geranyltranstransferase activity
X956_RS08135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
X956_RS08140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X956_RS08145	COG0839	Belongs to the complex I subunit 6 family
X956_RS08150	COG0713	ATP synthesis coupled electron transport
X956_RS08155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
X956_RS08165	COG1034	ATP synthesis coupled electron transport
X956_RS08170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
X956_RS08180	COG0649	NAD binding
X956_RS08185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X956_RS08190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
X956_RS08200	COG0644	oxidoreductase
X956_RS08205	COG2226	methyltransferase
X956_RS08210	COG1169	isochorismate synthase
X956_RS08215	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
X956_RS08220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X956_RS08230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
X956_RS08235	COG4948	Mandelate Racemase Muconate Lactonizing
X956_RS08240	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
X956_RS08250	COG1175	transmembrane transport
X956_RS08255	COG0395	ABC-type sugar transport system, permease component
X956_RS08275	COG1846	Transcriptional regulator
X956_RS08280	COG0406	alpha-ribazole phosphatase activity
X956_RS08300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
X956_RS08305	COG0569	domain protein
X956_RS08310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
X956_RS08320	COG1194	a g-specific adenine glycosylase
X956_RS08335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
X956_RS08340	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
X956_RS08345	COG0247	lactate metabolic process
X956_RS08350	COG3386	PFAM SMP-30 Gluconolaconase
X956_RS08360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X956_RS08365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
X956_RS08370	COG2409	Drug exporters of the RND superfamily
X956_RS08375	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
X956_RS08385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
X956_RS08390	COG2409	Drug exporters of the RND superfamily
X956_RS08405	COG2376	Dihydroxyacetone kinase
X956_RS08410	COG1461	Dihydroxyacetone kinase
X956_RS08415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
X956_RS08415	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
X956_RS08425	COG3250	beta-galactosidase activity
X956_RS08445	COG1609	Transcriptional regulator
X956_RS08455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
X956_RS08460	COG0302	gtp cyclohydrolase
X956_RS08490	COG0037	tRNA processing
X956_RS08505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
X956_RS08515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
X956_RS08520	COG2267	carboxylic ester hydrolase activity
X956_RS08530	COG0277	FAD linked oxidase domain protein
X956_RS08530	COG0247	lactate metabolic process
X956_RS08535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
X956_RS08535	COG0574	Belongs to the PEP-utilizing enzyme family
X956_RS08555	COG1175	transmembrane transport
X956_RS08560	COG0395	ABC-type sugar transport system, permease component
X956_RS08565	COG0366	Alpha amylase catalytic
X956_RS08580	COG1518	maintenance of DNA repeat elements
X956_RS08635	COG1285	pathogenesis
X956_RS08640	COG2271	Major facilitator Superfamily
X956_RS08645	COG1609	Transcriptional regulator
X956_RS08660	COG0737	Belongs to the 5'-nucleotidase family
X956_RS08675	COG1116	anion transmembrane transporter activity
X956_RS08680	COG2226	methyltransferase
X956_RS08685	COG1609	Transcriptional regulator
X956_RS08690	COG1129	ABC transporter
X956_RS08695	COG1172	Belongs to the binding-protein-dependent transport system permease family
X956_RS08700	COG1879	ABC-type sugar transport system periplasmic component
X956_RS08705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X956_RS08710	COG1869	D-ribose catabolic process
X956_RS08715	COG3250	beta-galactosidase activity
X956_RS08740	COG2610	gluconate transmembrane transporter activity
X956_RS08745	COG1609	Transcriptional regulator
X956_RS08755	COG3250	beta-galactosidase activity
X956_RS08770	COG1175	transmembrane transport
X956_RS08775	COG0395	ABC-type sugar transport system, permease component
X956_RS08785	COG1609	Transcriptional regulator
X956_RS08795	COG0395	ABC-type sugar transport system, permease component
X956_RS08815	COG1757	Na H antiporter
X956_RS08820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
X956_RS08825	COG4214	carbohydrate transport
X956_RS08835	COG4213	ABC transporter substrate-binding protein
X956_RS08840	COG1070	Carbohydrate kinase
X956_RS08845	COG2115	Belongs to the xylose isomerase family
X956_RS08870	COG0395	ABC-type sugar transport system, permease component
X956_RS08885	COG1349	DNA-binding transcription factor activity
X956_RS08890	COG1501	Belongs to the glycosyl hydrolase 31 family
X956_RS08905	COG0395	ABC-type sugar transport system, permease component
X956_RS08915	COG3119	arylsulfatase activity
X956_RS08925	COG2814	Major facilitator Superfamily
X956_RS08930	COG0641	radical SAM
X956_RS08935	COG0730	response to heat
X956_RS08940	COG0698	ribose 5-phosphate isomerase
X956_RS08950	COG2376	Dihydroxyacetone kinase
X956_RS08955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
X956_RS08995	COG2390	Transcriptional regulator
X956_RS09000	COG0738	Major facilitator superfamily
X956_RS09020	COG1490	D-aminoacyl-tRNA deacylase activity
X956_RS09030	COG0354	folic acid binding
X956_RS09035	COG3485	protocatechuate 3,4-dioxygenase
X956_RS09045	COG0737	Belongs to the 5'-nucleotidase family
X956_RS09055	COG1115	amino acid carrier protein
X956_RS09070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
X956_RS09075	COG0306	phosphate transporter
X956_RS09085	COG1115	amino acid carrier protein
X956_RS09100	COG0494	nUDIX hydrolase
X956_RS09100	COG0406	alpha-ribazole phosphatase activity
X956_RS09105	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
X956_RS09140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X956_RS09165	COG0728	peptidoglycan biosynthetic process
X956_RS09170	COG0039	L-malate dehydrogenase activity
X956_RS09200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
X956_RS09230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
X956_RS09235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
X956_RS09240	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
X956_RS09245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
X956_RS09255	COG0191	fructose-bisphosphate aldolase activity
X956_RS09270	COG0494	nUDIX hydrolase
X956_RS09285	COG1028	Short-chain dehydrogenase reductase Sdr
X956_RS09320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X956_RS09330	COG1506	peptidase
X956_RS09330	COG0823	Involved in the tonB-independent uptake of proteins
X956_RS09335	COG0584	glycerophosphoryl diester phosphodiesterase
X956_RS09355	COG0789	Transcriptional regulator
X956_RS09360	COG0484	heat shock protein binding
X956_RS09365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
X956_RS09370	COG0443	Heat shock 70 kDa protein
X956_RS09375	COG0167	dihydroorotate dehydrogenase activity
X956_RS09380	COG0167	dihydroorotate dehydrogenase activity
X956_RS09390	COG0284	orotidine-5'-phosphate decarboxylase activity
X956_RS09405	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
X956_RS09415	COG0446	pyridine nucleotide-disulphide oxidoreductase
X956_RS09420	COG1937	Protein conserved in bacteria
X956_RS09425	COG0243	molybdopterin cofactor binding
X956_RS09430	COG0437	4 iron, 4 sulfur cluster binding
X956_RS09440	COG1505	serine-type exopeptidase activity
X956_RS09450	COG0390	transport system, permease component
X956_RS09455	COG1940	carbohydrate kinase activity
X956_RS09485	COG0662	Cupin 2, conserved barrel domain protein
X956_RS09500	COG3842	ATPase activity
X956_RS09505	COG4149	molybdate abc transporter
X956_RS09535	COG0651	ATP synthesis coupled electron transport
X956_RS09540	COG1006	Multisubunit Na H antiporter MnhC subunit
X956_RS09545	COG2111	Na H antiporter
X956_RS09545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
X956_RS09550	COG0717	Belongs to the dCTP deaminase family
X956_RS09605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
X956_RS09610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
X956_RS09615	COG1754	DNA topoisomerase type I activity
X956_RS09615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
X956_RS09620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
X956_RS09620	COG2890	protein-(glutamine-N5) methyltransferase activity
X956_RS09630	COG3655	Transcriptional regulator
X956_RS09675	COG0596	Alpha beta hydrolase
X956_RS09705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X956_RS09735	COG0521	Mo-molybdopterin cofactor biosynthetic process
X956_RS09745	COG0315	cyclic pyranopterin monophosphate synthase activity
X956_RS09755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X956_RS09800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
X956_RS09805	COG4868	Belongs to the UPF0371 family
X956_RS09825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
X956_RS09860	COG0077	Prephenate dehydratase
X956_RS09870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
X956_RS09875	COG0561	phosphatase activity
X956_RS09910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X956_RS09915	COG1879	ABC-type sugar transport system periplasmic component
X956_RS09920	COG1172	Belongs to the binding-protein-dependent transport system permease family
X956_RS09950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
X956_RS09965	COG1487	ribonuclease activity
X956_RS09995	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
X956_RS10005	COG0395	ABC-type sugar transport system, permease component
X956_RS10010	COG1175	transmembrane transport
X956_RS10025	COG1609	Transcriptional regulator
X956_RS10030	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
X956_RS10035	COG1132	(ABC) transporter
X956_RS10055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X956_RS10065	COG1120	ATPase activity
X956_RS10075	COG2226	methyltransferase
X956_RS10080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X956_RS10085	COG0800	Aldolase
X956_RS10090	COG1312	Catalyzes the dehydration of D-mannonate
X956_RS10095	COG0246	Mannitol dehydrogenase
X956_RS10100	COG1414	Transcriptional regulator
X956_RS10105	COG0577	efflux transmembrane transporter activity
X956_RS10105	COG1136	(ABC) transporter
X956_RS10125	COG1328	CTP reductase activity
X956_RS10135	COG2197	response regulator
X956_RS10145	COG1136	(ABC) transporter
X956_RS10155	COG1131	(ABC) transporter
X956_RS10165	COG4585	Histidine kinase
X956_RS10170	COG2197	response regulator
X956_RS10175	COG1643	Atp-dependent helicase
X956_RS10190	COG2072	flavoprotein involved in K transport
X956_RS10210	COG1175	transmembrane transport
X956_RS10215	COG0395	ABC-type sugar transport system, permease component
X956_RS10235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X956_RS10245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
X956_RS10250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X956_RS10255	COG1780	Probably involved in ribonucleotide reductase function
X956_RS10270	COG1854	S-ribosylhomocysteine lyase activity
X956_RS10280	COG1716	ATPase activity
X956_RS10285	COG1131	(ABC) transporter
X956_RS10285	COG1716	ATPase activity
X956_RS10285	COG0842	Transport permease protein
X956_RS10350	COG3764	Sortase (surface protein transpeptidase)
X956_RS10385	COG1940	carbohydrate kinase activity
X956_RS10385	COG1846	Transcriptional regulator
X956_RS10480	COG1309	transcriptional regulator
X956_RS10575	COG0237	dephospho-CoA kinase activity
X956_RS10635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
X956_RS10645	COG1404	Belongs to the peptidase S8 family
X956_RS10665	COG0366	Alpha amylase catalytic
X956_RS10665	COG1470	cell adhesion involved in biofilm formation
X956_RS10680	COG0739	heme binding
X956_RS10685	COG0657	acetylesterase activity
X956_RS10690	COG2267	carboxylic ester hydrolase activity
X956_RS10705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
X956_RS10710	COG0791	NLP P60 protein
X956_RS10715	COG3525	Glycosyl hydrolase, family 20, catalytic domain
X956_RS10725	COG3250	beta-galactosidase activity
X956_RS10735	COG1349	DNA-binding transcription factor activity
X956_RS10765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
X956_RS10770	COG2212	antiporter activity
X956_RS10795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively