locus-tag	class	description
HEP79_RS00020	ENOG4105TZK	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
HEP79_RS00035	ENOG4105X54	addiction module antidote protein
HEP79_RS00050	ENOG4105CG3	alpha amylase, catalytic region
HEP79_RS00055	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HEP79_RS00075	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HEP79_RS00080	ENOG4105CQB	FAD linked oxidase domain protein
HEP79_RS00090	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
HEP79_RS00095	ENOG4105DWV	Homoserine O-trans-acetylase
HEP79_RS00100	ENOG4105K4H	Nlp p60 protein
HEP79_RS00105	ENOG4105F0N	pyrophosphate phospho-hydrolase
HEP79_RS00120	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HEP79_RS00130	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HEP79_RS00135	ENOG4105EUJ	GTP cyclohydrolase i
HEP79_RS00145	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HEP79_RS00165	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS00185	ENOG4105CNT	hydrolase family 2
HEP79_RS00195	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HEP79_RS00200	ENOG4108UTZ	Dihydroxyacetone kinase
HEP79_RS00205	ENOG4105CMT	Dihydroxyacetone kinase
HEP79_RS00215	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HEP79_RS00220	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HEP79_RS00230	ENOG4105CRK	lysyL-tRNA synthetase
HEP79_RS00235	ENOG4105EYF	MMPL domain protein
HEP79_RS00240	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HEP79_RS00245	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HEP79_RS00255	ENOG4105CYF	SMP-30 gluconolaconase LRE domain protein
HEP79_RS00260	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HEP79_RS00265	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
HEP79_RS00270	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
HEP79_RS00285	ENOG4105CEN	a g-specific adenine glycosylase
HEP79_RS00295	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HEP79_RS00300	ENOG4107ZYR	domain protein
HEP79_RS00305	ENOG4105CZN	Potassium uptake protein
HEP79_RS00320	ENOG4108ZT1	Transcriptional regulator
HEP79_RS00325	ENOG4108RH7	phosphoglycerate mutase
HEP79_RS00350	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
HEP79_RS00355	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
HEP79_RS00365	ENOG4107SIQ	Naphthoate synthase
HEP79_RS00370	ENOG4107TCW	O-succinylbenzoate synthase
HEP79_RS00375	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HEP79_RS00385	ENOG4105E4F	Isochorismate synthase
HEP79_RS00390	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HEP79_RS00395	ENOG4105P52	geranylgeranyl reductase
HEP79_RS00405	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HEP79_RS00410	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HEP79_RS00415	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HEP79_RS00425	ENOG4107QIZ	NADH dehydrogenase
HEP79_RS00430	ENOG4108IEH	NADH dehydrogenase subunit g
HEP79_RS00435	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HEP79_RS00440	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HEP79_RS00445	ENOG41087XN	oxidoreductase
HEP79_RS00450	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HEP79_RS00465	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HEP79_RS00475	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HEP79_RS00515	ENOG4105EYH	Exonuclease
HEP79_RS00525	ENOG4107TK4	histidinol-phosphate phosphatase
HEP79_RS00530	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HEP79_RS00535	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HEP79_RS00575	ENOG4105C3U	ABC transporter
HEP79_RS00580	ENOG4108JQ7	(ABC) transporter
HEP79_RS00585	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HEP79_RS00595	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
HEP79_RS00600	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HEP79_RS00605	ENOG4105CE4	GlcNAc 6-P deacetylase
HEP79_RS00610	ENOG4105EMN	RNA polymerase sigma factor
HEP79_RS00630	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HEP79_RS00635	ENOG4105C37	(CBS) domain
HEP79_RS00645	ENOG4105DR5	peptidase
HEP79_RS00650	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
HEP79_RS00665	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HEP79_RS00680	ENOG4105C75	arginyL-tRNA synthetase
HEP79_RS00690	ENOG4105D6E	homoserine dehydrogenase
HEP79_RS00695	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
HEP79_RS00700	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HEP79_RS00710	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HEP79_RS00715	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HEP79_RS00720	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HEP79_RS00740	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
HEP79_RS00745	ENOG4105ZA1	atp synthase
HEP79_RS00750	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HEP79_RS00755	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HEP79_RS00760	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HEP79_RS00765	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HEP79_RS00770	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HEP79_RS00785	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
HEP79_RS00825	ENOG4105CG3	alpha amylase, catalytic region
HEP79_RS00830	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS00845	ENOG4105EG2	ABC transporter, permease
HEP79_RS00860	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HEP79_RS00865	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
HEP79_RS00870	ENOG4105CG3	alpha amylase, catalytic region
HEP79_RS00875	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
HEP79_RS00885	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HEP79_RS00910	ENOG4105C31	Tryptophanyl-tRNA synthetase
HEP79_RS00940	ENOG41063PX	domain protein
HEP79_RS00950	ENOG4105DJZ	UPF0182 protein
HEP79_RS00955	ENOG4105ESP	cell wall surface anchor family protein
HEP79_RS00975	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HEP79_RS00980	ENOG4105CZV	ABC transporter
HEP79_RS00990	ENOG4105EWV	Sodium calcium exchanger membrane region
HEP79_RS01025	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HEP79_RS01060	ENOG4105BZU	Histidine kinase
HEP79_RS01065	ENOG4108RAV	Conserved protein
HEP79_RS01070	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HEP79_RS01075	ENOG4105FDP	GntR family transcriptional regulator
HEP79_RS01080	ENOG4108KD5	ADP-ribosylation crystallin J1
HEP79_RS01090	ENOG4108TFM	Kinase, PfkB family
HEP79_RS01095	ENOG4107R3N	Filamentation induced by cAMP protein fic
HEP79_RS01105	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HEP79_RS01110	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HEP79_RS01115	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HEP79_RS01120	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HEP79_RS01125	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HEP79_RS01175	ENOG4105C01	Dihydroxy-acid dehydratase
HEP79_RS01180	ENOG4105D0C	transport protein
HEP79_RS01190	ENOG4108ZP8	Acetolactate synthase small subunit
HEP79_RS01195	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HEP79_RS01205	ENOG4108IJ0	Aspartate ammonia-lyase
HEP79_RS01220	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HEP79_RS01225	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HEP79_RS01235	ENOG4105C6N	Formate acetyltransferase
HEP79_RS01250	ENOG4105DFA	alanine racemase domain protein
HEP79_RS01265	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HEP79_RS01275	ENOG4105KPE	licD family
HEP79_RS01295	ENOG4105CKK	Glycosyl transferase, family 2
HEP79_RS01305	ENOG4108XUD	Membrane
HEP79_RS01340	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HEP79_RS01370	ENOG4105C29	acyl-CoA thioesterase
HEP79_RS01385	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HEP79_RS01395	ENOG4105CKW	Inner membrane protein yedI
HEP79_RS01400	ENOG4105C9K	Endothelin-converting enzyme 1
HEP79_RS01415	ENOG4105D7W	serine acetyltransferase
HEP79_RS01425	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HEP79_RS01440	ENOG4107QN2	dihydrolipoyl dehydrogenase
HEP79_RS01455	ENOG4105C5H	ABC transporter
HEP79_RS01470	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS01475	ENOG4105CNT	hydrolase family 2
HEP79_RS01480	ENOG4105CT4	transporter
HEP79_RS01485	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HEP79_RS01495	ENOG4105CPC	Aldo Keto reductase
HEP79_RS01500	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HEP79_RS01505	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HEP79_RS01510	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HEP79_RS01515	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HEP79_RS01520	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
HEP79_RS01530	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HEP79_RS01555	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HEP79_RS01560	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HEP79_RS01565	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HEP79_RS01580	ENOG4105E5P	Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation
HEP79_RS01585	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HEP79_RS01610	ENOG4105K5M	30s ribosomal protein S16
HEP79_RS01615	ENOG41082KU	UPF0109 protein
HEP79_RS01620	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HEP79_RS01630	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HEP79_RS01635	ENOG4107QYR	Signal peptidase i
HEP79_RS01640	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HEP79_RS01665	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HEP79_RS01670	ENOG4108K5P	(LipO)protein
HEP79_RS01675	ENOG4105EN6	Membrane
HEP79_RS01680	ENOG4105CE9	30S ribosomal protein S2
HEP79_RS01685	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HEP79_RS01695	ENOG4105C10	Electron transfer flavoprotein
HEP79_RS01700	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HEP79_RS01720	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HEP79_RS01725	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HEP79_RS01735	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HEP79_RS01745	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HEP79_RS01750	ENOG4105DZP	Membrane-associated zinc metalloprotease
HEP79_RS01755	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HEP79_RS01765	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HEP79_RS01775	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
HEP79_RS01790	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HEP79_RS01795	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HEP79_RS01800	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HEP79_RS01805	ENOG4105BZU	Histidine kinase
HEP79_RS01810	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HEP79_RS01815	ENOG4105CXY	transporter
HEP79_RS01825	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HEP79_RS01855	ENOG4105CJ1	ABC, transporter
HEP79_RS01865	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HEP79_RS01870	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HEP79_RS01880	ENOG4105C1V	Peptidase, M16
HEP79_RS01885	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HEP79_RS01890	ENOG4105C0D	helicase
HEP79_RS01905	ENOG4105CN5	Metallo-Beta-Lactamase
HEP79_RS01910	ENOG4107QZI	cell division protein FtsK
HEP79_RS01925	ENOG4105CEV	competence damage-inducible protein
HEP79_RS01930	ENOG4105WBV	Transcriptional regulator
HEP79_RS01940	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HEP79_RS01945	ENOG4105Y3E	Modulates RecA activity (By similarity)
HEP79_RS01950	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HEP79_RS01955	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HEP79_RS01960	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
HEP79_RS01965	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HEP79_RS01975	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HEP79_RS01985	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HEP79_RS01990	ENOG4105CEY	Amp-dependent synthetase and ligase
HEP79_RS01995	ENOG4108JQ1	Dehydrogenase
HEP79_RS02025	ENOG4108V6E	Cell division protein mraZ
HEP79_RS02030	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HEP79_RS02040	ENOG4105CJN	penicillin-binding protein
HEP79_RS02045	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HEP79_RS02055	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HEP79_RS02060	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HEP79_RS02070	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HEP79_RS02075	ENOG4105DFU	Cell wall formation (By similarity)
HEP79_RS02085	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HEP79_RS02095	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
HEP79_RS02125	ENOG4105C0B	DNA polymerase III (alpha subunit)
HEP79_RS02140	ENOG41090R7	Ferric uptake
HEP79_RS02145	ENOG4105CC5	ABC transporter
HEP79_RS02150	ENOG4105DIK	(ABC) transporter
HEP79_RS02160	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HEP79_RS02180	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HEP79_RS02185	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HEP79_RS02195	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HEP79_RS02200	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HEP79_RS02235	ENOG4105EHG	Permease protein
HEP79_RS02240	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HEP79_RS02270	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HEP79_RS02275	ENOG4105ECP	epimerase
HEP79_RS02295	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HEP79_RS02315	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HEP79_RS02340	ENOG4108680	CrcB-like protein
HEP79_RS02345	ENOG41082CG	Protein CrcB homolog
HEP79_RS02350	ENOG4105EGD	dinuclear metal center protein, YbgI family
HEP79_RS02360	ENOG4105D1Q	UPF0246 protein
HEP79_RS02370	ENOG4105DFK	Polyphosphate glucokinase
HEP79_RS02385	ENOG4105C5F	glutamine synthetase
HEP79_RS02390	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HEP79_RS02400	ENOG4105C5F	glutamine synthetase
HEP79_RS02435	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HEP79_RS02450	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HEP79_RS02490	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
HEP79_RS02495	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
HEP79_RS02530	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HEP79_RS02535	ENOG4105DVT	helicase
HEP79_RS02540	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HEP79_RS02555	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HEP79_RS02595	ENOG4107VEG	TrkA-N domain protein
HEP79_RS02605	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HEP79_RS02610	ENOG4107QM5	aconitate hydratase
HEP79_RS02620	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HEP79_RS02685	ENOG4105WH1	Two component transcriptional regulator luxr family
HEP79_RS02690	ENOG4105EJQ	L-serine dehydratase
HEP79_RS02695	ENOG4105C22	threonyL-tRNA synthetase
HEP79_RS02710	ENOG4105E2K	Glycosyl transferase (Group 1
HEP79_RS02720	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HEP79_RS02725	ENOG4105CDY	transcriptional regulatory protein
HEP79_RS02730	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HEP79_RS02735	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HEP79_RS02740	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HEP79_RS02750	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HEP79_RS02755	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HEP79_RS02760	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HEP79_RS02765	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HEP79_RS02775	ENOG4105C99	atpase involved in dna repair
HEP79_RS02780	ENOG4105C5X	domain protein
HEP79_RS02785	ENOG4105CUT	histidyl-tRNA synthetase
HEP79_RS02790	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HEP79_RS02795	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HEP79_RS02815	ENOG4105C9M	aspartyl-trna synthetase
HEP79_RS02830	ENOG4107R13	MMPL domain protein
HEP79_RS02840	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HEP79_RS02850	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HEP79_RS02855	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HEP79_RS02875	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HEP79_RS02880	ENOG4105D49	3-dehydroquinate synthase
HEP79_RS02885	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HEP79_RS02890	ENOG4105C59	p-type ATPase
HEP79_RS02895	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HEP79_RS02900	ENOG410803B	Involved in the transcription termination process (By similarity)
HEP79_RS02920	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HEP79_RS02925	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HEP79_RS02935	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HEP79_RS02940	ENOG4107RSZ	Primosomal protein n'
HEP79_RS02945	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HEP79_RS02955	ENOG4105DJV	ribulose-phosphate 3-epimerase
HEP79_RS02960	ENOG4108I05	Binding-protein-dependent transport systems, inner membrane component
HEP79_RS02965	ENOG4107XKF	NMT1 THI5 Like Domain Protein
HEP79_RS02970	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
HEP79_RS02975	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HEP79_RS03005	ENOG4105CQR	helicase
HEP79_RS03015	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HEP79_RS03060	ENOG4105CTQ	phosphohexokinase
HEP79_RS03065	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HEP79_RS03080	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HEP79_RS03085	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HEP79_RS03105	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HEP79_RS03125	ENOG4105CP7	Triose-phosphate isomerase
HEP79_RS03130	ENOG4105BZA	Phosphoglycerate kinase
HEP79_RS03135	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HEP79_RS03140	ENOG4105CIE	May be required for sporulation (By similarity)
HEP79_RS03150	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HEP79_RS03155	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HEP79_RS03160	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HEP79_RS03170	ENOG4105DHU	Bile acid
HEP79_RS03180	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HEP79_RS03185	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HEP79_RS03190	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
HEP79_RS03195	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HEP79_RS03205	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HEP79_RS03230	ENOG4105CA9	Pyruvate kinase
HEP79_RS03235	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HEP79_RS03240	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HEP79_RS03245	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HEP79_RS03250	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HEP79_RS03265	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
HEP79_RS03270	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
HEP79_RS03275	ENOG4105E5F	proteasome
HEP79_RS03280	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
HEP79_RS03295	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
HEP79_RS03300	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HEP79_RS03315	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HEP79_RS03320	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
HEP79_RS03325	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HEP79_RS03350	ENOG4105C0B	DNA polymerase III (alpha subunit)
HEP79_RS03365	ENOG4108V1U	phospholipid-binding protein
HEP79_RS03400	ENOG4105DKW	ABC transporter
HEP79_RS03405	ENOG4107QPH	glycogen) synthase
HEP79_RS03410	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HEP79_RS03415	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HEP79_RS03425	ENOG4105EAC	phosphoserine phosphatase
HEP79_RS03435	ENOG4105C5H	ABC transporter
HEP79_RS03440	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
HEP79_RS03445	ENOG4105VG1	fes assembly suf system protein
HEP79_RS03460	ENOG4105C3K	feS assembly ATPase SufC
HEP79_RS03490	ENOG4105CJR	Integral membrane protein (MviN
HEP79_RS03510	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HEP79_RS03515	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HEP79_RS03530	ENOG4105DSU	hydrolase
HEP79_RS03560	ENOG4105CC5	ABC transporter
HEP79_RS03565	ENOG4107RPQ	ABC transporter
HEP79_RS03570	ENOG4105DIK	(ABC) transporter
HEP79_RS03575	ENOG4107SIG	periplasmic solute binding protein
HEP79_RS03580	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HEP79_RS03585	ENOG4108M15	ABC transporter
HEP79_RS03595	ENOG4105VZ8	Transcriptional regulator
HEP79_RS03605	ENOG4105CMR	udp-glucose 4-epimerase
HEP79_RS03610	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
HEP79_RS03625	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HEP79_RS03630	ENOG4108Z66	YbaK ebsC protein
HEP79_RS03635	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HEP79_RS03650	ENOG4108RWN	rrna methyltransferase
HEP79_RS03660	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HEP79_RS03665	ENOG41084BS	50S ribosomal protein L35
HEP79_RS03670	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HEP79_RS03680	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HEP79_RS03685	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HEP79_RS03695	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HEP79_RS03705	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HEP79_RS03710	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HEP79_RS03715	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
HEP79_RS03720	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HEP79_RS03755	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HEP79_RS03765	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HEP79_RS03770	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HEP79_RS03775	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HEP79_RS03795	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HEP79_RS03800	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HEP79_RS03825	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HEP79_RS03830	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HEP79_RS03835	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HEP79_RS03855	ENOG4105D7A	ATP-binding protein
HEP79_RS03870	ENOG4105C8T	Leucyl-tRNA synthetase
HEP79_RS03895	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HEP79_RS03900	ENOG4107RPQ	ABC transporter
HEP79_RS03905	ENOG4107104	thymidine kinase
HEP79_RS03925	ENOG4107SIG	periplasmic solute binding protein
HEP79_RS03940	ENOG4105CC5	ABC transporter
HEP79_RS03960	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HEP79_RS03970	ENOG41067QW	Transcriptional regulator
HEP79_RS03980	ENOG4105C85	amino acid
HEP79_RS03985	ENOG4107GFK	fumarate
HEP79_RS03995	ENOG4108UMI	ABC transporter, permease
HEP79_RS04000	ENOG4105D01	(LipO)protein
HEP79_RS04005	ENOG4105C85	amino acid
HEP79_RS04015	ENOG4108UMN	azlc family
HEP79_RS04020	ENOG4105CFP	Peptidase U32
HEP79_RS04035	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HEP79_RS04080	ENOG4107VMI	polysaccharide deacetylase
HEP79_RS04085	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HEP79_RS04090	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS04095	ENOG4105NWF	RbsD or FucU transport
HEP79_RS04100	ENOG4105EDR	glucose galactose transporter
HEP79_RS04105	ENOG4105FB2	class II Aldolase
HEP79_RS04140	ENOG4105CVJ	phosphoglycerate mutase
HEP79_RS04145	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HEP79_RS04155	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HEP79_RS04160	ENOG41080RH	Thioredoxin
HEP79_RS04170	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HEP79_RS04175	ENOG4105K46	50S ribosomal protein l27
HEP79_RS04180	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HEP79_RS04185	ENOG4105C03	ribonuclease
HEP79_RS04190	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HEP79_RS04195	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HEP79_RS04200	ENOG4108JJ9	ABC, transporter
HEP79_RS04205	ENOG4108JJ8	(ABC) transporter
HEP79_RS04215	ENOG4105BZ1	(ABC) transporter
HEP79_RS04220	ENOG4105BZ1	(ABC) transporter
HEP79_RS04225	ENOG4105D3R	alkyl hydroperoxide reductase
HEP79_RS04230	ENOG4108JU3	Alkyl hydroperoxide reductase
HEP79_RS04240	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HEP79_RS04245	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HEP79_RS04260	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HEP79_RS04275	ENOG4105VB9	50S ribosomal protein l28
HEP79_RS04285	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HEP79_RS04295	ENOG4105CPF	Cell wall formation (By similarity)
HEP79_RS04300	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HEP79_RS04310	ENOG4105DZW	Dipeptidase
HEP79_RS04320	ENOG4105JNK	Glycosyl transferase (Group 1
HEP79_RS04330	ENOG4105CSC	Glucose uptake protein
HEP79_RS04335	ENOG4105DGW	oligopeptidase A
HEP79_RS04370	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS04390	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HEP79_RS04395	ENOG4105C87	Aminotransferase class I and II
HEP79_RS04400	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HEP79_RS04405	ENOG4108IQE	Amp-dependent synthetase and ligase
HEP79_RS04430	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HEP79_RS04435	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HEP79_RS04445	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HEP79_RS04455	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HEP79_RS04475	ENOG4108426	dNA-binding protein
HEP79_RS04480	ENOG4107WGA	YidE YbjL
HEP79_RS04495	ENOG4105C4K	Nad synthetase
HEP79_RS04570	ENOG4105GVJ	transcriptional regulator
HEP79_RS04575	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HEP79_RS04580	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HEP79_RS04615	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HEP79_RS04620	ENOG4105DR5	peptidase
HEP79_RS04625	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HEP79_RS04630	ENOG4105CAK	Cell division ATP-binding protein ftsE
HEP79_RS04635	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HEP79_RS04695	ENOG4105C1J	atp-dependent rna helicase
HEP79_RS04700	ENOG41081FY	multiple antibiotic resistance (MarC)-related
HEP79_RS04710	ENOG4107T6F	Xaa-Pro aminopeptidase
HEP79_RS04715	ENOG4105CJW	magnesium transporter
HEP79_RS04740	ENOG4108URH	decarboxylase
HEP79_RS04750	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
HEP79_RS04755	ENOG4105KBX	Transcriptional regulator, TetR family
HEP79_RS04760	ENOG4105E5M	Multidrug resistance protein D
HEP79_RS04765	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HEP79_RS04790	ENOG4105UIB	(ABC) transporter
HEP79_RS04795	ENOG4108JQ9	ABC transporter
HEP79_RS04800	ENOG4105DIH	basic membrane
HEP79_RS04805	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HEP79_RS04820	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HEP79_RS04825	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HEP79_RS04835	ENOG4107ZYJ	bioY protein
HEP79_RS04845	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HEP79_RS04850	ENOG4105D8K	carboxyl transferase
HEP79_RS04855	ENOG4108JIK	carboxylase
HEP79_RS04875	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HEP79_RS04880	ENOG4105C10	Electron transfer flavoprotein
HEP79_RS04895	ENOG4105C5X	domain protein
HEP79_RS04900	ENOG4105C54	Major Facilitator superfamily
HEP79_RS04910	ENOG4105CEY	Amp-dependent synthetase and ligase
HEP79_RS04945	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HEP79_RS04960	ENOG4105F9F	transposase
HEP79_RS04965	ENOG4105F9F	transposase
HEP79_RS05010	ENOG4107QP8	phosphohexose isomerase
HEP79_RS05015	ENOG4105CTQ	phosphohexokinase
HEP79_RS05045	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HEP79_RS05050	ENOG4105EXC	Acyl-transferase
HEP79_RS05065	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HEP79_RS05115	ENOG4105DF9	Lipoate-protein, ligase
HEP79_RS05320	ENOG4107QMH	DNA methylase
HEP79_RS05385	ENOG4105DR9	pseudouridine synthase
HEP79_RS05390	ENOG4105C6K	Malic enzyme
HEP79_RS05460	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HEP79_RS05465	ENOG4105C12	Phosphoribosylglycinamide synthetase
HEP79_RS05470	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HEP79_RS05475	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HEP79_RS05480	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HEP79_RS05485	ENOG4105C8V	SAICAR synthetase
HEP79_RS05490	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HEP79_RS05500	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HEP79_RS05510	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
HEP79_RS05515	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HEP79_RS05520	ENOG4105C8J	)-transporter
HEP79_RS05530	ENOG4105E33	succinate dehydrogenase
HEP79_RS05560	ENOG4108097	ATP-binding protein
HEP79_RS05565	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HEP79_RS05575	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HEP79_RS05580	ENOG4105CS9	pantothenic acid kinase
HEP79_RS05590	ENOG4108UJD	30S ribosomal protein S9
HEP79_RS05595	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HEP79_RS05605	ENOG4108V7D	UPF0397 protein
HEP79_RS05610	ENOG4108JJB	ABC transporter
HEP79_RS05620	ENOG4105JQN	Transcriptional regulator
HEP79_RS05630	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HEP79_RS05635	ENOG4105DFK	Polyphosphate glucokinase
HEP79_RS05645	ENOG4105E5Q	amino acid AbC transporter
HEP79_RS05650	ENOG4105CDA	abc transporter atp-binding protein
HEP79_RS05655	ENOG4107TXC	Transcriptional regulator
HEP79_RS05660	ENOG4108VPT	UPF0234 protein
HEP79_RS05665	ENOG4108ZT0	50S ribosomal protein l17
HEP79_RS05670	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HEP79_RS05680	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HEP79_RS05685	ENOG41067V7	50S ribosomal protein L36
HEP79_RS05690	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HEP79_RS05700	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HEP79_RS05710	ENOG4107ZG5	Binds to the 23S rRNA (By similarity)
HEP79_RS05715	ENOG4105VPB	50S ribosomal protein L30
HEP79_RS05720	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HEP79_RS05730	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HEP79_RS05735	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HEP79_RS05740	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HEP79_RS05745	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HEP79_RS05750	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HEP79_RS05755	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HEP79_RS05760	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HEP79_RS05770	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HEP79_RS05775	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HEP79_RS05780	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HEP79_RS05785	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HEP79_RS05790	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HEP79_RS05795	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HEP79_RS05800	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HEP79_RS05805	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HEP79_RS05810	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HEP79_RS05815	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HEP79_RS05825	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HEP79_RS05830	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HEP79_RS05835	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HEP79_RS05840	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HEP79_RS05845	ENOG4108IQI	permease
HEP79_RS05850	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HEP79_RS05855	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HEP79_RS05860	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HEP79_RS05865	ENOG4108VZM	50s ribosomal protein L10
HEP79_RS05875	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HEP79_RS05880	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HEP79_RS05885	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HEP79_RS05910	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HEP79_RS05925	ENOG4107R4N	Cell wall formation (By similarity)
HEP79_RS05935	ENOG4105WDJ	50S ribosomal protein L33
HEP79_RS05955	ENOG4108VPT	UPF0234 protein
HEP79_RS05965	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
HEP79_RS05970	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HEP79_RS05975	ENOG4108T3R	lipoprotein lpqB
HEP79_RS05980	ENOG4105BZU	Histidine kinase
HEP79_RS05985	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HEP79_RS06005	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HEP79_RS06045	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
HEP79_RS06060	ENOG4105C09	Bile acid
HEP79_RS06065	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HEP79_RS06090	ENOG4107RGC	Glycosyl transferase, family 2
HEP79_RS06100	ENOG4105EY8	ABC transporter
HEP79_RS06125	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HEP79_RS06185	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HEP79_RS06195	ENOG4107RGC	Glycosyl transferase, family 2
HEP79_RS06200	ENOG4108KGH	TRANSCRIPTIONal
HEP79_RS06205	ENOG4108KGH	TRANSCRIPTIONal
HEP79_RS06220	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HEP79_RS06235	ENOG4107WR6	Maf-like protein
HEP79_RS06255	ENOG4108Z4U	Ferredoxin
HEP79_RS06270	ENOG4105CI3	gtp-binding protein typa
HEP79_RS06280	ENOG4105BZ1	(ABC) transporter
HEP79_RS06310	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HEP79_RS06315	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HEP79_RS06325	ENOG4105DFM	M18 family aminopeptidase
HEP79_RS06340	ENOG4105E9K	Isocitrate dehydrogenase
HEP79_RS06345	ENOG4105CUC	YeeE YedE family protein
HEP79_RS06360	ENOG4105CJQ	hydrolase, family 31
HEP79_RS06370	ENOG4105DRS	transport system, permease
HEP79_RS06375	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HEP79_RS06380	ENOG4105E2R	ROK family
HEP79_RS06385	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS06410	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HEP79_RS06440	ENOG4108JQ7	(ABC) transporter
HEP79_RS06450	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HEP79_RS06465	ENOG4105TMB	Formate nitrite transporter
HEP79_RS06475	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HEP79_RS06480	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HEP79_RS06505	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
HEP79_RS06515	ENOG4108YYH	Nadph-dependent fmn reductase
HEP79_RS06520	ENOG4108RFG	Tetr family transcriptional regulator
HEP79_RS06525	ENOG4105CSH	Transporter
HEP79_RS06545	ENOG4105DBV	ornithine carbamoyltransferase
HEP79_RS06565	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
HEP79_RS06575	ENOG4105BZ7	extracellular solute-binding protein family 1
HEP79_RS06580	ENOG4105CG3	alpha amylase, catalytic region
HEP79_RS06590	ENOG4105CH2	amidohydrolase
HEP79_RS06595	ENOG4105CSH	Transporter
HEP79_RS06620	ENOG4105C3G	gtp-binding protein
HEP79_RS06625	ENOG4105CGY	Dna recombination protein
HEP79_RS06630	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HEP79_RS06640	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HEP79_RS06645	ENOG4105D7K	pfkb domain protein
HEP79_RS06650	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HEP79_RS06660	ENOG4105T1M	mycothiol conjugate amidase mca
HEP79_RS06665	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HEP79_RS06670	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HEP79_RS06685	ENOG4105CK7	Sodium proline symporter
HEP79_RS06690	ENOG4105C26	Dehydrogenase
HEP79_RS06705	ENOG4105CZV	ABC transporter
HEP79_RS06710	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
HEP79_RS06755	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HEP79_RS06770	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HEP79_RS06780	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HEP79_RS06785	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HEP79_RS06795	ENOG4108IG5	Transcriptional regulator
HEP79_RS06810	ENOG4108IUX	(ABC) transporter
HEP79_RS06815	ENOG4105RHA	ABC transporter, permease
HEP79_RS06825	ENOG4105C5H	ABC transporter
HEP79_RS06830	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HEP79_RS06835	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HEP79_RS06845	ENOG4105F8V	Hydrolase, tatD family
HEP79_RS06850	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HEP79_RS06885	ENOG4108RWI	nicotinamidase
HEP79_RS06925	ENOG4105DA5	(ABC) transporter
HEP79_RS06940	ENOG4107RNR	Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity)
HEP79_RS06945	ENOG4105C94	Transporter
HEP79_RS06965	ENOG4105CRK	lysyL-tRNA synthetase
HEP79_RS06970	ENOG4105DAA	L-lactate
HEP79_RS06975	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HEP79_RS06980	ENOG4107QR9	Iron-sulfur cluster binding protein
HEP79_RS06985	ENOG41080R8	Conserved Protein
HEP79_RS07005	ENOG41082BZ	phosphocarrier protein (HPr)
HEP79_RS07010	ENOG4105C5Y	PTS System
HEP79_RS07045	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HEP79_RS07065	ENOG4105ECB	domain protein
HEP79_RS07075	ENOG4105CAG	UPF0210 protein
HEP79_RS07080	ENOG4105VUC	UPF0237 protein
HEP79_RS07095	ENOG4108638	50S ribosomal protein L36
HEP79_RS07100	ENOG4105NRA	50s ribosomal protein l31 type b
HEP79_RS07105	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HEP79_RS07110	ENOG4105W0E	50S ribosomal protein L33
HEP79_RS07115	ENOG4105KDC	50s ribosomal protein l28
HEP79_RS07140	ENOG4105FDP	GntR family transcriptional regulator
HEP79_RS07145	ENOG4105E0A	ABC, transporter
HEP79_RS07150	ENOG4108U1V	ABC transporter, permease
HEP79_RS07155	ENOG4108U1V	ABC transporter, permease
HEP79_RS07160	ENOG4108HUF	Transporter
HEP79_RS07175	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HEP79_RS07190	ENOG4105VUH	addiction module killer protein
HEP79_RS07195	ENOG4105YES	addiction module antidote protein
HEP79_RS07270	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HEP79_RS07275	ENOG4105C7N	Xanthine uracil vitamin C permease
HEP79_RS07280	ENOG4105EIP	mannose-6-phosphate isomerase
HEP79_RS07290	ENOG4105VEQ	Cold shock protein
HEP79_RS07310	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HEP79_RS07315	ENOG4105BZU	Histidine kinase
HEP79_RS07325	ENOG4105PDP	Short chain dehydrogenase
HEP79_RS07335	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HEP79_RS07350	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HEP79_RS07410	ENOG4105CK5	oxidoreductase
HEP79_RS07420	ENOG4108JE9	extracellular solute-binding protein family 1
HEP79_RS07425	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HEP79_RS07450	ENOG4105CFH	Aspartokinase
HEP79_RS07455	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HEP79_RS07470	ENOG4105D22	carbon starvation protein
HEP79_RS07710	ENOG4105C2W	permease
HEP79_RS07730	ENOG4105C8N	cysteinyl-tRNA synthetase
HEP79_RS07740	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HEP79_RS07765	ENOG4105CMT	Dihydroxyacetone kinase
HEP79_RS07780	ENOG4105DT3	PTS system, galactitol-specific IIc component
HEP79_RS07800	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HEP79_RS07805	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HEP79_RS07820	ENOG4105BZU	Histidine kinase
HEP79_RS07830	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HEP79_RS07870	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS07905	ENOG4105E0A	ABC, transporter
HEP79_RS07910	ENOG4105EHG	Permease protein
HEP79_RS07925	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
HEP79_RS07940	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HEP79_RS07950	ENOG4107RES	phosphoglycerol transferase I
HEP79_RS07965	ENOG4105VE1	Phosphatidylcholine synthase
HEP79_RS07970	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HEP79_RS07975	ENOG4105CPC	Aldo Keto reductase
HEP79_RS07985	ENOG4105FF2	Type I DHQase
HEP79_RS08000	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HEP79_RS08005	ENOG41082T9	Membrane
HEP79_RS08010	ENOG4107QTF	adenylosuccinate lyase
HEP79_RS08015	ENOG4107T5V	SNARE associated Golgi
HEP79_RS08060	ENOG4105BZ1	(ABC) transporter
HEP79_RS08065	ENOG4108JJB	ABC transporter
HEP79_RS08085	ENOG4105CPQ	Dehydrogenase
HEP79_RS08090	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS08095	ENOG4105CXY	transporter
HEP79_RS08100	ENOG4105ECY	inositol monophosphatase
HEP79_RS08105	ENOG4105D4B	ABC, transporter
HEP79_RS08110	ENOG4105CNN	ABC, transporter
HEP79_RS08120	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HEP79_RS08135	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HEP79_RS08155	ENOG4105DH8	myo-inositol catabolism
HEP79_RS08160	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
HEP79_RS08165	ENOG4105C26	Dehydrogenase
HEP79_RS08170	ENOG4108IPW	abc transporter atp-binding protein
HEP79_RS08175	ENOG4105CM4	permease protein
HEP79_RS08180	ENOG4105DHS	permease protein
HEP79_RS08185	ENOG4108MES	Periplasmic binding protein
HEP79_RS08190	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HEP79_RS08195	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HEP79_RS08200	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HEP79_RS08205	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HEP79_RS08210	ENOG4105D2H	Uronic isomerase
HEP79_RS08225	ENOG4106N3A	copper homeostasis protein cutc
HEP79_RS08240	ENOG4108NZE	NAGC-like transcriptional regulator
HEP79_RS08255	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HEP79_RS08265	ENOG4105DKQ	ROK family
HEP79_RS08270	ENOG4105E2R	ROK family
HEP79_RS08320	ENOG4108JJB	ABC transporter
HEP79_RS08325	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
HEP79_RS08340	ENOG4105C8P	)-transporter
HEP79_RS08365	ENOG4105C5I	Dehydrogenase
HEP79_RS08375	ENOG41071MT	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
HEP79_RS08385	ENOG4105D4B	ABC, transporter
HEP79_RS08395	ENOG4108EMV	Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity)
HEP79_RS08405	ENOG41061GT	Aldolase
HEP79_RS08420	ENOG4105CEP	NADH dehydrogenase
HEP79_RS08425	ENOG4108UVJ	appr-1-p processing domain protein
HEP79_RS08465	ENOG4105CQ7	ATP-dependent helicase
HEP79_RS08480	ENOG4105CZN	Potassium uptake protein
HEP79_RS08510	ENOG4107RBB	ABC transporter, permease
HEP79_RS08515	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HEP79_RS08530	ENOG4105F44	Two component transcriptional regulator, winged helix family
HEP79_RS08535	ENOG4106F60	Histidine kinase
HEP79_RS08540	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HEP79_RS08550	ENOG4105ZMH	deoxynucleoside kinase
HEP79_RS08590	ENOG4105CV8	reductase
HEP79_RS08595	ENOG4105DWF	phosphomethylpyrimidine kinase
HEP79_RS08605	ENOG4105CUZ	uba thif-type nad fad binding protein
HEP79_RS08615	ENOG4107Y80	Major Facilitator superfamily
HEP79_RS08620	ENOG4105CDU	Replicative dna helicase
HEP79_RS08635	ENOG4105CGH	5'-nucleotidase
HEP79_RS08640	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HEP79_RS08645	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HEP79_RS08650	ENOG4107YH6	single-stranded DNA-binding protein
HEP79_RS08655	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
HEP79_RS08660	ENOG4105BZ4	penicillin-binding protein
HEP79_RS08665	ENOG4105DSF	transport protein
HEP79_RS08675	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HEP79_RS08695	ENOG4105C3M	thioredoxin reductase
HEP79_RS08700	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HEP79_RS08705	ENOG4105CPF	Cell wall formation (By similarity)
HEP79_RS08715	ENOG4107QJE	Chromosome Partitioning Protein
HEP79_RS08720	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HEP79_RS08730	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HEP79_RS08735	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HEP79_RS08750	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HEP79_RS08755	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HEP79_RS08760	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HEP79_RS08770	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HEP79_RS08775	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HEP79_RS08820	ENOG4105ZJT	Cell division protein CrgA
HEP79_RS08825	ENOG4108RN7	integral membrane protein
HEP79_RS08835	ENOG4105D9P	serine threonine protein kinase
HEP79_RS08860	ENOG4105IDI	abc transporter atp-binding protein
HEP79_RS08880	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HEP79_RS08890	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HEP79_RS08895	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HEP79_RS08910	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
HEP79_RS08915	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HEP79_RS08920	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HEP79_RS08930	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HEP79_RS08935	ENOG4107ZF2	Phosphatase
HEP79_RS08950	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
HEP79_RS08955	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
HEP79_RS08975	ENOG4105H3G	oxidoreductase
HEP79_RS08985	ENOG4105CQ7	ATP-dependent helicase
HEP79_RS08990	ENOG4108S01	response regulator
HEP79_RS08995	ENOG4108ZGX	Histidine kinase
HEP79_RS09005	ENOG4108M15	ABC transporter
HEP79_RS09015	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HEP79_RS09025	ENOG4105WH1	Two component transcriptional regulator luxr family
HEP79_RS09030	ENOG4105DSB	aldose 1-epimerase
HEP79_RS09035	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HEP79_RS09040	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HEP79_RS09055	ENOG4105CDA	abc transporter atp-binding protein
HEP79_RS09060	ENOG4108FUF	Transcriptional regulator, IclR family
HEP79_RS09065	ENOG4105DEI	Mannitol dehydrogenase
HEP79_RS09070	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HEP79_RS09075	ENOG4108UHU	Aldolase
HEP79_RS09080	ENOG4105D7K	pfkb domain protein
HEP79_RS09085	ENOG4105DXX	methyltransferase
HEP79_RS09095	ENOG4105E0A	ABC, transporter
HEP79_RS09105	ENOG4105DQ5	transport system permease protein
HEP79_RS09120	ENOG4105BZ1	(ABC) transporter
HEP79_RS09125	ENOG4108JJ8	(ABC) transporter
HEP79_RS09130	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS09160	ENOG4105NUN	Orthopoxvirus protein of unknown function (DUF830)
HEP79_RS09210	ENOG4105CEC	DNA methylase N-4 N-6
HEP79_RS09260	ENOG4105C2M	dna polymerase I
HEP79_RS09265	ENOG4105WXW	Antirepressor
HEP79_RS09310	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HEP79_RS09340	ENOG4105CAR	Terminase, large subunit
HEP79_RS09350	ENOG4105EFC	phage portal protein HK97 family
HEP79_RS09425	ENOG4105XSJ	toxin secretion phage lysis holin
HEP79_RS09495	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HEP79_RS09525	ENOG4105CNN	ABC, transporter
HEP79_RS09530	ENOG4105D4B	ABC, transporter
HEP79_RS09535	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HEP79_RS09540	ENOG4108RVA	ribokinase
HEP79_RS09570	ENOG4108KP7	hydrolase
HEP79_RS09575	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HEP79_RS09585	ENOG4105CQC	Prephenate dehydratase
HEP79_RS09610	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HEP79_RS09615	ENOG4108Z6B	deaminase
HEP79_RS09625	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HEP79_RS09630	ENOG4105DPH	UPF0371 protein
HEP79_RS09635	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HEP79_RS09685	ENOG4105EPU	Molybdenum cofactor synthesis domain protein
HEP79_RS09695	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HEP79_RS09705	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HEP79_RS09715	ENOG4108IUK	alpha amylase, catalytic
HEP79_RS09730	ENOG4105BZ4	penicillin-binding protein
HEP79_RS09765	ENOG4105D74	hydrolase
HEP79_RS09815	ENOG4105VMP	Transcriptional regulator
HEP79_RS09825	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HEP79_RS09830	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HEP79_RS09835	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HEP79_RS09840	ENOG4105C6E	dna polymerase iii
HEP79_RS09865	ENOG4105CMM	transposase
HEP79_RS09915	ENOG4105DHP	deoxycytidine triphosphate deaminase
HEP79_RS09920	ENOG4105D65	subunit l
HEP79_RS09925	ENOG4105MKQ	Monovalent cation H antiporter subunit C
HEP79_RS09930	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HEP79_RS09960	ENOG4105E0C	molybdate abc transporter
HEP79_RS09965	ENOG4108UCS	ABC, transporter
HEP79_RS09985	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
HEP79_RS10015	ENOG4105DKQ	ROK family
HEP79_RS10020	ENOG4105C4B	ABC transporter, permease
HEP79_RS10040	ENOG4105QAX	Iron-sulfur
HEP79_RS10045	ENOG4107QY8	reductase
HEP79_RS10055	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HEP79_RS10075	ENOG4107QY8	reductase
HEP79_RS10085	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HEP79_RS10090	ENOG4105CXT	aspartate transcarbamylase
HEP79_RS10095	ENOG4105CD3	dihydroorotase
HEP79_RS10100	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HEP79_RS10105	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HEP79_RS10115	ENOG4105CFG	Acts as a chaperone (By similarity)
HEP79_RS10120	ENOG4108093	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HEP79_RS10125	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HEP79_RS10130	ENOG4105KNI	merR family transcriptional Regulator
HEP79_RS10150	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HEP79_RS10155	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HEP79_RS10165	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HEP79_RS10175	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HEP79_RS10210	ENOG4105M6F	mutator MutT protein
HEP79_RS10225	ENOG4107RCW	fructose-bisphosphate aldolase
HEP79_RS10235	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HEP79_RS10240	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
HEP79_RS10245	ENOG4105C8V	SAICAR synthetase
HEP79_RS10250	ENOG4105D82	Glutamate dehydrogenase
HEP79_RS10280	ENOG4105C94	Transporter
HEP79_RS10295	ENOG4108YG4	
HEP79_RS10310	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HEP79_RS10315	ENOG4105CJR	Integral membrane protein (MviN
HEP79_RS10340	ENOG4105E0X	reductase
HEP79_RS10365	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HEP79_RS10375	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
HEP79_RS10390	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HEP79_RS10395	ENOG4105CJ3	phosphate transporter
HEP79_RS10415	ENOG4105CGH	5'-nucleotidase
HEP79_RS10425	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
HEP79_RS10430	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
HEP79_RS10440	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HEP79_RS10460	ENOG4105EDR	glucose galactose transporter
HEP79_RS10465	ENOG4107RHR	regulatoR
HEP79_RS10475	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HEP79_RS10480	ENOG4105CMG	Carbohydrate kinase
HEP79_RS10485	ENOG4108ZYE	Transcriptional regulator
HEP79_RS10495	ENOG4105EF1	ribulokinase
HEP79_RS10505	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HEP79_RS10510	ENOG4105CMT	Dihydroxyacetone kinase
HEP79_RS10520	ENOG4107YVI	ribose 5-phosphate isomerase
HEP79_RS10525	ENOG4108VCT	Sulfite exporter TauE/SafE
HEP79_RS10530	ENOG4105C4X	radical SAM domain protein
HEP79_RS10535	ENOG4105C54	Major Facilitator superfamily
HEP79_RS10540	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS10570	ENOG4105CJQ	hydrolase, family 31
HEP79_RS10580	ENOG4105E98	transcriptional regulator DeoR family
HEP79_RS10595	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HEP79_RS10610	ENOG4107QKS	N-acylglucosamine 2-epimerase
HEP79_RS10620	ENOG4105C93	Xylose Isomerase
HEP79_RS10630	ENOG4105DFW	ABC transporter
HEP79_RS10640	ENOG4108HWW	ABC transporter
HEP79_RS10645	ENOG4105C87	Aminotransferase class I and II
HEP79_RS10650	ENOG4105DFD	Na H antiporter
HEP79_RS10670	ENOG4105DRS	transport system, permease
HEP79_RS10680	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS10690	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HEP79_RS10695	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HEP79_RS10710	ENOG4105CNT	hydrolase family 2
HEP79_RS10720	ENOG41060NJ	transcriptional regulator
HEP79_RS10730	ENOG4105C6Z	Gluconate
HEP79_RS10740	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HEP79_RS10750	ENOG4105E2D	ec 3.2.1.52
HEP79_RS10755	ENOG4105CNT	hydrolase family 2
HEP79_RS10760	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HEP79_RS10765	ENOG4108RVA	ribokinase
HEP79_RS10770	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HEP79_RS10775	ENOG4105CNN	ABC, transporter
HEP79_RS10780	ENOG4105C2J	ABC transporter
HEP79_RS10785	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS10790	ENOG41089UC	methyltransferase, type 11
HEP79_RS10815	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HEP79_RS10830	ENOG4105ETE	Transcriptional regulator (LacI family
HEP79_RS10835	ENOG4105C54	Major Facilitator superfamily
HEP79_RS10840	ENOG4105KT7	mgtC SapB transporter
HEP79_RS10870	ENOG4105CJ1	ABC, transporter
HEP79_RS10885	ENOG4108UVJ	appr-1-p processing domain protein