locus-tag	class	description
HLG82_RS00030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLG82_RS00060	COG0596	Alpha beta hydrolase
HLG82_RS00105	COG1205	dead DEAH box helicase
HLG82_RS00105	COG1111	helicase
HLG82_RS00110	COG3655	Transcriptional regulator
HLG82_RS00125	COG1754	DNA topoisomerase type I activity
HLG82_RS00125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLG82_RS00130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLG82_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLG82_RS00245	COG2184	nucleotidyltransferase activity
HLG82_RS00265	COG1192	Involved in chromosome partitioning
HLG82_RS00275	COG4974	Belongs to the 'phage' integrase family
HLG82_RS00320	COG0588	phosphoglycerate mutase activity
HLG82_RS00330	COG0704	Plays a role in the regulation of phosphate uptake
HLG82_RS00340	COG0745	RESPONSE REGULATOR receiver
HLG82_RS00350	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HLG82_RS00355	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HLG82_RS00370	COG0215	cysteine-tRNA ligase activity
HLG82_RS00375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG82_RS00390	COG2233	PERMEase
HLG82_RS00430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLG82_RS00455	COG1175	transmembrane transport
HLG82_RS00460	COG1653	transport
HLG82_RS00475	COG3842	ATPase activity
HLG82_RS00500	COG1609	Transcriptional regulator
HLG82_RS00520	COG1175	transmembrane transport
HLG82_RS00525	COG0395	ABC-type sugar transport system, permease component
HLG82_RS00535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HLG82_RS00550	COG0459	protein refolding
HLG82_RS00560	COG4221	oxidoreductase activity
HLG82_RS00570	COG2205	protein histidine kinase activity
HLG82_RS00575	COG0745	RESPONSE REGULATOR receiver
HLG82_RS00585	COG1842	Phage shock protein A
HLG82_RS00595	COG1278	Cold shock
HLG82_RS00605	COG1482	cell wall glycoprotein biosynthetic process
HLG82_RS00610	COG2252	PERMEase
HLG82_RS00620	COG1321	iron dependent repressor
HLG82_RS00685	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLG82_RS00705	COG0596	Alpha beta hydrolase
HLG82_RS00720	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HLG82_RS00725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG82_RS00730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG82_RS00735	COG1120	ATPase activity
HLG82_RS00740	COG2188	Transcriptional regulator
HLG82_RS00745	COG0657	acetylesterase activity
HLG82_RS00750	COG0477	Major facilitator Superfamily
HLG82_RS00770	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLG82_RS00775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLG82_RS00780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLG82_RS00785	COG0254	rRNA binding
HLG82_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLG82_RS00795	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_RS00800	COG3830	Belongs to the UPF0237 family
HLG82_RS00805	COG2848	UPF0210 protein
HLG82_RS00815	COG1511	domain protein
HLG82_RS00830	COG3711	transcriptional antiterminator
HLG82_RS00835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLG82_RS00845	COG1051	belongs to the nudix hydrolase family
HLG82_RS00850	COG1131	(ABC) transporter
HLG82_RS00865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLG82_RS00865	COG1263	PTS System
HLG82_RS00875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLG82_RS00895	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_RS00900	COG1556	Lactate utilization protein
HLG82_RS00910	COG0247	lactate metabolic process
HLG82_RS00915	COG1620	l-lactate permease
HLG82_RS00940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG82_RS00950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG82_RS00955	COG1120	ATPase activity
HLG82_RS00970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG82_RS00975	COG0667	Aldo Keto reductase
HLG82_RS00980	COG2813	Specifically methylates the guanine in position
HLG82_RS00995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG82_RS01005	COG2873	o-acetylhomoserine
HLG82_RS01025	COG1335	isochorismatase
HLG82_RS01035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG82_RS01040	COG0084	hydrolase, TatD family'
HLG82_RS01050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLG82_RS01055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HLG82_RS01060	COG0488	(ABC) transporter
HLG82_RS01070	COG1668	transmembrane transport
HLG82_RS01075	COG4152	abc transporter atp-binding protein
HLG82_RS01090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLG82_RS01100	COG1136	(ABC) transporter
HLG82_RS01105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HLG82_RS01115	COG0193	aminoacyl-tRNA hydrolase activity
HLG82_RS01130	COG0148	phosphopyruvate hydratase activity
HLG82_RS01155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLG82_RS01185	COG1131	(ABC) transporter
HLG82_RS01200	COG1012	belongs to the aldehyde dehydrogenase family
HLG82_RS01205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLG82_RS01215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLG82_RS01220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLG82_RS01225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLG82_RS01240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLG82_RS01245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLG82_RS01250	COG1722	exodeoxyribonuclease VII activity
HLG82_RS01255	COG1570	exodeoxyribonuclease VII activity
HLG82_RS01260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HLG82_RS01265	COG1322	Protein conserved in bacteria
HLG82_RS01270	COG0012	GTP binding
HLG82_RS01340	COG4626	Terminase
HLG82_RS01340	COG1802	Transcriptional regulator
HLG82_RS01370	COG0740	serine-type endopeptidase activity
HLG82_RS01440	COG4824	toxin secretion phage lysis holin
HLG82_RS01460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLG82_RS01510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLG82_RS01510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLG82_RS01535	COG0778	Nitroreductase
HLG82_RS01545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLG82_RS01550	COG3547	Transposase (IS116 IS110 IS902 family)
HLG82_RS01570	COG1970	mechanosensitive ion channel activity
HLG82_RS01575	COG0242	peptide deformylase activity
HLG82_RS01585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLG82_RS01595	COG2116	formate transmembrane transporter activity
HLG82_RS01615	COG0425	Belongs to the sulfur carrier protein TusA family
HLG82_RS01620	COG2391	methyltransferase activity
HLG82_RS01625	COG2838	Isocitrate dehydrogenase
HLG82_RS01640	COG1362	aminopeptidase activity
HLG82_RS01650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLG82_RS01655	COG0321	lipoyl(octanoyl) transferase activity
HLG82_RS01690	COG1132	(ABC) transporter
HLG82_RS01695	COG1132	(ABC) transporter
HLG82_RS01705	COG1217	gtp-binding protein TYPA
HLG82_RS01740	COG0424	maF-like protein
HLG82_RS01755	COG0745	RESPONSE REGULATOR receiver
HLG82_RS01760	COG0642	Histidine kinase
HLG82_RS01770	COG1316	TRANSCRIPTIONal
HLG82_RS01790	COG1088	dTDP-glucose 4,6-dehydratase activity
HLG82_RS01805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLG82_RS01815	COG0673	inositol 2-dehydrogenase activity
HLG82_RS01825	COG0438	transferase activity, transferring glycosyl groups
HLG82_RS01865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HLG82_RS01905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HLG82_RS01920	COG0483	inositol monophosphate 1-phosphatase activity
HLG82_RS01965	COG0714	Associated with various cellular activities
HLG82_RS01985	COG0745	RESPONSE REGULATOR receiver
HLG82_RS01990	COG5002	protein histidine kinase activity
HLG82_RS01995	COG5401	PFAM Sporulation and spore germination
HLG82_RS02005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLG82_RS02015	COG1666	GTP binding
HLG82_RS02035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLG82_RS02040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HLG82_RS02055	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HLG82_RS02065	COG0436	Aminotransferase
HLG82_RS02085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLG82_RS02090	COG0081	regulation of translation
HLG82_RS02095	COG0572	uridine kinase
HLG82_RS02100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HLG82_RS02105	COG0222	ribosome binding
HLG82_RS02110	COG0085	RNA polymerase activity
HLG82_RS02115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLG82_RS02120	COG0833	amino acid
HLG82_RS02125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLG82_RS02130	COG0049	tRNA binding
HLG82_RS02135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HLG82_RS02140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLG82_RS02150	COG0051	transcription antitermination factor activity, RNA binding
HLG82_RS02155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HLG82_RS02160	COG0088	Forms part of the polypeptide exit tunnel
HLG82_RS02165	COG0089	rRNA binding
HLG82_RS02170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLG82_RS02175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLG82_RS02180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HLG82_RS02185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HLG82_RS02190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HLG82_RS02205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HLG82_RS02210	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HLG82_RS02215	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HLG82_RS02220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLG82_RS02225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HLG82_RS02230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HLG82_RS02240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HLG82_RS02245	COG1841	ribosomal large subunit assembly
HLG82_RS02250	COG0200	Binds to the 23S rRNA
HLG82_RS02255	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_RS02270	COG0563	adenylate kinase activity
HLG82_RS02275	COG0024	Methionine aminopeptidase
HLG82_RS02280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HLG82_RS02285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLG82_RS02290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HLG82_RS02300	COG0202	RNA polymerase activity
HLG82_RS02305	COG0203	ribosomal protein L17
HLG82_RS02310	COG0789	Transcriptional regulator
HLG82_RS02320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLG82_RS02330	COG0640	Transcriptional regulator
HLG82_RS02335	COG1126	abc transporter atp-binding protein
HLG82_RS02340	COG0765	amino acid transport
HLG82_RS02350	COG1940	carbohydrate kinase activity
HLG82_RS02355	COG0101	tRNA pseudouridine synthase activity
HLG82_RS02370	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLG82_RS02375	COG1122	ATPase activity
HLG82_RS02380	COG4720	Psort location CytoplasmicMembrane, score
HLG82_RS02390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HLG82_RS02395	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLG82_RS02405	COG1072	(Pantothenic acid kinase))
HLG82_RS02410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLG82_RS02420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLG82_RS02425	COG0802	atpase or kinase
HLG82_RS02450	COG1053	succinate dehydrogenase
HLG82_RS02455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLG82_RS02465	COG0733	neurotransmitter:sodium symporter activity
HLG82_RS02470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HLG82_RS02485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HLG82_RS02495	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLG82_RS02500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLG82_RS02505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLG82_RS02510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HLG82_RS02515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLG82_RS02520	COG0151	Belongs to the GarS family
HLG82_RS02525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLG82_RS02545	COG0516	GMP reductase activity
HLG82_RS02550	COG0114	fumarate hydratase activity
HLG82_RS02560	COG1136	(ABC) transporter
HLG82_RS02575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLG82_RS02580	COG0280	phosphate acetyltransferase
HLG82_RS02580	COG0857	belongs to the CobB CobQ family
HLG82_RS02585	COG0564	pseudouridine synthase activity
HLG82_RS02605	COG5646	InterPro IPR014922
HLG82_RS02615	COG2755	lipolytic protein G-D-S-L family
HLG82_RS02615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HLG82_RS02620	COG0045	succinate-CoA ligase (ADP-forming) activity
HLG82_RS02640	COG0138	bifunctional purine biosynthesis protein purh
HLG82_RS02650	COG0205	6-phosphofructokinase activity
HLG82_RS02655	COG0166	Belongs to the GPI family
HLG82_RS02665	COG0039	L-malate dehydrogenase activity
HLG82_RS02675	COG0110	maltose O-acetyltransferase activity
HLG82_RS02705	COG2030	dehydratase
HLG82_RS02710	COG2271	Major facilitator Superfamily
HLG82_RS02735	COG0644	oxidoreductase
HLG82_RS02755	COG4770	biotin carboxylase activity
HLG82_RS02760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLG82_RS02765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLG82_RS02770	COG0736	holo-[acyl-carrier-protein] synthase activity
HLG82_RS02775	COG1268	BioY protein
HLG82_RS02785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLG82_RS02790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLG82_RS02810	COG1744	ABC transporter substrate-binding protein PnrA-like
HLG82_RS02815	COG3845	ABC transporter
HLG82_RS02820	COG4603	Belongs to the binding-protein-dependent transport system permease family
HLG82_RS02825	COG1079	Belongs to the binding-protein-dependent transport system permease family
HLG82_RS02845	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HLG82_RS02850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLG82_RS02860	COG1611	Belongs to the LOG family
HLG82_RS02885	COG2239	Acts as a magnesium transporter
HLG82_RS02890	COG0006	proline dipeptidase activity
HLG82_RS02900	COG2095	MarC family integral membrane protein
HLG82_RS02905	COG0513	Belongs to the DEAD box helicase family
HLG82_RS02920	COG0210	DNA helicase
HLG82_RS02980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HLG82_RS02985	COG2884	Cell division ATP-binding protein ftsE
HLG82_RS02990	COG2177	Part of the ABC transporter FtsEX involved in
HLG82_RS02995	COG0739	heme binding
HLG82_RS03000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HLG82_RS03010	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLG82_RS03045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLG82_RS03045	COG0352	thiamine-phosphate diphosphorylase activity
HLG82_RS03045	COG0351	phosphomethylpyrimidine kinase
HLG82_RS03050	COG0477	Major facilitator Superfamily
HLG82_RS03055	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HLG82_RS03060	COG0352	thiamine-phosphate diphosphorylase activity
HLG82_RS03075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLG82_RS03115	COG3547	Transposase (IS116 IS110 IS902 family)
HLG82_RS03170	COG0778	Nitroreductase
HLG82_RS03190	COG0737	Belongs to the 5'-nucleotidase family
HLG82_RS03200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HLG82_RS03215	COG2985	domain, Protein
HLG82_RS03215	COG0569	domain protein
HLG82_RS03225	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_RS03245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HLG82_RS03255	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLG82_RS03260	COG1234	tRNA 3'-trailer cleavage
HLG82_RS03265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HLG82_RS03270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HLG82_RS03295	COG1022	Amp-dependent synthetase and ligase
HLG82_RS03300	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLG82_RS03325	COG1609	Transcriptional regulator
HLG82_RS03360	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_RS03365	COG0339	signal peptide processing
HLG82_RS03370	COG4975	Glucose uptake
HLG82_RS03385	COG0438	transferase activity, transferring glycosyl groups
HLG82_RS03395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLG82_RS03400	COG0066	3-isopropylmalate dehydratase activity
HLG82_RS03415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLG82_RS03425	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLG82_RS03445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLG82_RS03450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLG82_RS03460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HLG82_RS03475	COG0571	ribonuclease III activity
HLG82_RS03480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HLG82_RS03500	COG1132	(ABC) transporter
HLG82_RS03505	COG1132	(ABC) transporter
HLG82_RS03520	COG4988	ABC transporter
HLG82_RS03525	COG1294	oxidase, subunit
HLG82_RS03530	COG1271	oxidase subunit
HLG82_RS03535	COG1530	ribonuclease E activity
HLG82_RS03540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HLG82_RS03545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HLG82_RS03550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLG82_RS03560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLG82_RS03565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLG82_RS03575	COG0799	negative regulation of ribosome biogenesis
HLG82_RS03580	COG0406	alpha-ribazole phosphatase activity
HLG82_RS03595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLG82_RS03630	COG1136	(ABC) transporter
HLG82_RS03690	COG0133	tryptophan synthase activity
HLG82_RS03720	COG3250	beta-galactosidase activity
HLG82_RS03730	COG1609	Transcriptional regulator
HLG82_RS03755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG82_RS03760	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HLG82_RS03765	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HLG82_RS03770	COG0826	peptidase U32
HLG82_RS03775	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLG82_RS03785	COG1113	amino acid transport
HLG82_RS03795	COG2011	ABC-type metal ion transport system permease component
HLG82_RS03800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG82_RS03805	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HLG82_RS03805	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HLG82_RS03815	COG1113	amino acid transport
HLG82_RS03830	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_RS03840	COG0671	phosphoesterase, PA-phosphatase related
HLG82_RS03860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG82_RS03865	COG1121	(ABC) transporter
HLG82_RS03895	COG1435	thymidine kinase activity
HLG82_RS03900	COG1321	iron dependent repressor
HLG82_RS03900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG82_RS03905	COG0813	purine-nucleoside phosphorylase activity
HLG82_RS03930	COG0495	leucyl-tRNA aminoacylation
HLG82_RS03940	COG0433	COG0433 Predicted ATPase
HLG82_RS03945	COG1596	polysaccharide export
HLG82_RS03945	COG1555	photosystem II stabilization
HLG82_RS03960	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HLG82_RS03965	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HLG82_RS03970	COG0268	Binds directly to 16S ribosomal RNA
HLG82_RS03975	COG3237	CsbD-like
HLG82_RS03995	COG0481	GTPase activity
HLG82_RS04000	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLG82_RS04020	COG1420	regulation of RNA biosynthetic process
HLG82_RS04025	COG0484	heat shock protein binding
HLG82_RS04040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HLG82_RS04080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLG82_RS04085	COG1381	Involved in DNA repair and RecF pathway recombination
HLG82_RS04090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLG82_RS04095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLG82_RS04105	COG0131	Imidazoleglycerol-phosphate dehydratase
HLG82_RS04115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLG82_RS04120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HLG82_RS04130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HLG82_RS04135	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HLG82_RS04150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG82_RS04155	COG1902	pentaerythritol trinitrate reductase activity
HLG82_RS04175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLG82_RS04180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HLG82_RS04190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLG82_RS04195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HLG82_RS04200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLG82_RS04205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLG82_RS04215	COG0137	argininosuccinate synthase activity
HLG82_RS04225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HLG82_RS04230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLG82_RS04235	COG0165	Argininosuccinate lyase
HLG82_RS04240	COG1476	TRANSCRIPTIONal
HLG82_RS04255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLG82_RS04265	COG1121	(ABC) transporter
HLG82_RS04270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG82_RS04275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG82_RS04300	COG0647	UMP catabolic process
HLG82_RS04315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HLG82_RS04320	COG0497	DNA recombination
HLG82_RS04340	COG0728	peptidoglycan biosynthetic process
HLG82_RS04360	COG0719	Fe-S assembly protein
HLG82_RS04385	COG2151	metal-sulfur cluster biosynthetic enzyme
HLG82_RS04390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLG82_RS04400	COG0488	(ABC) transporter
HLG82_RS04415	COG3830	Belongs to the UPF0237 family
HLG82_RS04415	COG0560	Phosphoserine phosphatase
HLG82_RS04425	COG0297	glycogen (starch) synthase activity
HLG82_RS04430	COG1119	ATPase activity
HLG82_RS04445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG82_RS04460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLG82_RS04465	COG1881	PFAM PEBP family protein
HLG82_RS04480	COG0587	DNA-directed DNA polymerase activity
HLG82_RS04500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HLG82_RS04505	COG0519	Catalyzes the synthesis of GMP from XMP
HLG82_RS04510	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HLG82_RS04515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLG82_RS04530	COG1968	undecaprenyl-diphosphatase activity
HLG82_RS04535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLG82_RS04550	COG1222	aaa ATPase
HLG82_RS04555	COG4122	O-methyltransferase activity
HLG82_RS04565	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HLG82_RS04580	COG0107	imidazoleglycerol-phosphate synthase activity
HLG82_RS04590	COG0134	indole-3-glycerol-phosphate synthase activity
HLG82_RS04595	COG0133	tryptophan synthase activity
HLG82_RS04605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HLG82_RS04610	COG0469	pyruvate kinase activity
HLG82_RS04635	COG2226	methyltransferase
HLG82_RS04640	COG0539	negative regulation of cytoplasmic translation
HLG82_RS04645	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HLG82_RS04650	COG0237	dephospho-CoA kinase activity
HLG82_RS04655	COG0556	nucleotide-excision repair
HLG82_RS04680	COG0322	excinuclease ABC activity
HLG82_RS04695	COG1481	regulation of sporulation
HLG82_RS04700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLG82_RS04705	COG0126	phosphoglycerate kinase activity
HLG82_RS04710	COG0149	triose-phosphate isomerase activity
HLG82_RS04715	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLG82_RS04730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLG82_RS04755	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLG82_RS04765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HLG82_RS04770	COG1160	GTP binding
HLG82_RS04775	COG0205	6-phosphofructokinase activity
HLG82_RS04785	COG1834	amidinotransferase
HLG82_RS04795	COG1716	ATPase activity
HLG82_RS04820	COG1216	Glycosyl transferase, family 2
HLG82_RS04860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLG82_RS04865	COG0140	phosphoribosyl-ATP diphosphatase activity
HLG82_RS04870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG82_RS04875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG82_RS04880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLG82_RS04890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLG82_RS04900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLG82_RS04910	COG1758	RNA polymerase activity
HLG82_RS04915	COG0194	GDP metabolic process
HLG82_RS04925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLG82_RS04930	COG0505	Belongs to the CarA family
HLG82_RS04935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLG82_RS04940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HLG82_RS04945	COG2217	Heavy metal translocating P-type atpase
HLG82_RS04960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HLG82_RS04980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HLG82_RS04985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLG82_RS04995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HLG82_RS05005	COG2409	Drug exporters of the RND superfamily
HLG82_RS05020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HLG82_RS05025	COG2814	Major facilitator Superfamily
HLG82_RS05040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HLG82_RS05045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLG82_RS05050	COG0124	histidyl-tRNA synthetase
HLG82_RS05060	COG1196	nuclear chromosome segregation
HLG82_RS05070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLG82_RS05075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLG82_RS05080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLG82_RS05085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLG82_RS05095	COG2255	four-way junction helicase activity
HLG82_RS05100	COG0632	four-way junction helicase activity
HLG82_RS05105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HLG82_RS05110	COG0217	transcriptional regulatory protein
HLG82_RS05130	COG0438	transferase activity, transferring glycosyl groups
HLG82_RS05140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLG82_RS05145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLG82_RS05150	COG1760	l-serine dehydratase
HLG82_RS05155	COG2197	response regulator
HLG82_RS05215	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HLG82_RS05220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLG82_RS05225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLG82_RS05240	COG0569	domain protein
HLG82_RS05285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLG82_RS05300	COG0187	DNA topoisomerase II activity
HLG82_RS05315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLG82_RS05330	COG0142	geranyltranstransferase activity
HLG82_RS05345	COG2815	serine threonine protein kinase
HLG82_RS05345	COG0515	serine threonine protein kinase
HLG82_RS05350	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HLG82_RS05355	COG0205	6-phosphofructokinase activity
HLG82_RS05405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLG82_RS05420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLG82_RS05430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG82_RS05435	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG82_RS05455	COG0174	glutamine synthetase
HLG82_RS05485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HLG82_RS05490	COG0174	glutamine synthetase
HLG82_RS05505	COG1940	carbohydrate kinase activity
HLG82_RS05525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLG82_RS05530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLG82_RS05535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLG82_RS05560	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HLG82_RS05565	COG0477	Major facilitator Superfamily
HLG82_RS05585	COG0009	L-threonylcarbamoyladenylate synthase
HLG82_RS05605	COG1090	epimerase
HLG82_RS05645	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HLG82_RS05650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG82_RS05680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLG82_RS05685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLG82_RS05690	COG0805	protein transport
HLG82_RS05700	COG0358	DNA primase activity
HLG82_RS05715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLG82_RS05725	COG0423	glycine-tRNA ligase activity
HLG82_RS05735	COG1121	(ABC) transporter
HLG82_RS05740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG82_RS05755	COG2501	S4 domain
HLG82_RS05760	COG0587	DNA-directed DNA polymerase activity
HLG82_RS05775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HLG82_RS05790	COG1799	cell septum assembly
HLG82_RS05795	COG1496	oxidoreductase activity
HLG82_RS05800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLG82_RS05810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLG82_RS05815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLG82_RS05825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLG82_RS05830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLG82_RS05835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLG82_RS05840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLG82_RS05845	COG0768	penicillin binding
HLG82_RS05855	COG0275	rRNA processing
HLG82_RS05860	COG2001	Belongs to the MraZ family
HLG82_RS05870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLG82_RS05895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLG82_RS05900	COG0318	PFAM AMP-dependent synthetase and ligase
HLG82_RS05905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLG82_RS05925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLG82_RS05930	COG2813	Specifically methylates the guanine in position
HLG82_RS05935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HLG82_RS05940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLG82_RS05945	COG2137	regulation of response to DNA damage stimulus
HLG82_RS05950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLG82_RS05960	COG1396	sequence-specific DNA binding
HLG82_RS05965	COG1058	Belongs to the CinA family
HLG82_RS05965	COG1546	Belongs to the CinA family
HLG82_RS05980	COG1674	ftsk spoiiie
HLG82_RS05985	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLG82_RS05990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG82_RS06005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLG82_RS06010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HLG82_RS06015	COG0612	Peptidase, M16
HLG82_RS06025	COG1185	polyribonucleotide nucleotidyltransferase activity
HLG82_RS06055	COG2801	Transposase and inactivated derivatives
HLG82_RS06090	COG1131	(ABC) transporter
HLG82_RS06120	COG3842	ATPase activity
HLG82_RS06130	COG2271	Major facilitator Superfamily
HLG82_RS06140	COG5002	protein histidine kinase activity
HLG82_RS06145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLG82_RS06150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLG82_RS06155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HLG82_RS06170	COG0779	Required for maturation of 30S ribosomal subunits
HLG82_RS06180	COG0442	prolyl-tRNA aminoacylation
HLG82_RS06190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HLG82_RS06195	COG0750	zinc metalloprotease
HLG82_RS06200	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HLG82_RS06210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HLG82_RS06220	COG0233	cytoplasmic translational termination
HLG82_RS06225	COG0528	UMP kinase activity
HLG82_RS06240	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_RS06250	COG0644	oxidoreductase
HLG82_RS06255	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HLG82_RS06265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HLG82_RS06270	COG0052	Belongs to the universal ribosomal protein uS2 family
HLG82_RS06275	COG2860	membrane
HLG82_RS06285	COG4974	Belongs to the 'phage' integrase family
HLG82_RS06300	COG0792	nuclease activity
HLG82_RS06310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLG82_RS06315	COG0681	Belongs to the peptidase S26 family
HLG82_RS06320	COG0335	large ribosomal subunit rRNA binding
HLG82_RS06330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLG82_RS06335	COG1837	Belongs to the UPF0109 family
HLG82_RS06345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLG82_RS06365	COG1473	amidohydrolase
HLG82_RS06370	COG3069	C4-dicarboxylate transmembrane transporter activity
HLG82_RS06385	COG0105	UTP biosynthetic process
HLG82_RS06395	COG0285	dihydrofolate synthase activity
HLG82_RS06400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLG82_RS06415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLG82_RS06435	COG0287	Prephenate dehydrogenase
HLG82_RS06435	COG1605	Chorismate mutase
HLG82_RS06440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HLG82_RS06445	COG0740	serine-type endopeptidase activity
HLG82_RS06450	COG0740	serine-type endopeptidase activity
HLG82_RS06455	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLG82_RS06460	COG0667	Aldo Keto reductase
HLG82_RS06485	COG0393	Putative heavy-metal-binding
HLG82_RS06515	COG1739	Uncharacterized protein family UPF0029
HLG82_RS06525	COG1045	serine acetyltransferase
HLG82_RS06535	COG3590	peptidase
HLG82_RS06540	COG2354	Protein conserved in bacteria
HLG82_RS06555	COG2818	Glycosylase
HLG82_RS06560	COG1263	PTS System
HLG82_RS06560	COG2190	(PTS) system
HLG82_RS06560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLG82_RS06590	COG1162	GTPase activity
HLG82_RS06600	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HLG82_RS06625	COG1216	Glycosyl transferase, family 2
HLG82_RS06625	COG0463	Glycosyl transferase, family 2
HLG82_RS06630	COG2244	polysaccharide biosynthetic process
HLG82_RS06655	COG1442	glycosyl transferase family 8
HLG82_RS06655	COG1216	Glycosyl transferase, family 2
HLG82_RS06660	COG3475	LICD family
HLG82_RS06665	COG4750	Nucleotidyl transferase
HLG82_RS06700	COG1882	Formate acetyltransferase
HLG82_RS06705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLG82_RS06710	COG0473	3-isopropylmalate dehydrogenase activity
HLG82_RS06730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HLG82_RS06735	COG0440	acetolactate synthase activity
HLG82_RS06745	COG0569	domain protein
HLG82_RS06745	COG2985	domain, Protein
HLG82_RS06750	COG0129	dihydroxy-acid dehydratase activity
HLG82_RS06810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLG82_RS06815	COG0154	amidase activity
HLG82_RS06820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLG82_RS06825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG82_RS06835	COG1404	Belongs to the peptidase S8 family
HLG82_RS06840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLG82_RS06845	COG2135	peptidase activity
HLG82_RS06850	COG4585	Histidine kinase
HLG82_RS06860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG82_RS06875	COG4989	oxidoreductase activity
HLG82_RS06890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HLG82_RS06895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLG82_RS06910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLG82_RS06915	COG1053	succinate dehydrogenase
HLG82_RS06925	COG0387	Pfam Sodium calcium exchanger
HLG82_RS06935	COG1131	(ABC) transporter
HLG82_RS06940	COG1725	Transcriptional regulator
HLG82_RS06950	COG3547	Transposase (IS116 IS110 IS902 family)
HLG82_RS06975	COG1470	cell adhesion involved in biofilm formation
HLG82_RS06975	COG0366	Alpha amylase catalytic
HLG82_RS06980	COG1615	UPF0182 protein
HLG82_RS06990	COG3480	Lon protease (S16) C-terminal proteolytic domain
HLG82_RS07020	COG0180	Tryptophanyl-tRNA synthetase
HLG82_RS07025	COG0058	SHG alpha-glucan phosphorylase activity
HLG82_RS07035	COG0366	Alpha amylase catalytic
HLG82_RS07050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HLG82_RS07065	COG3833	ABC-type maltose transport systems, permease component
HLG82_RS07070	COG1175	transmembrane transport
HLG82_RS07085	COG0366	Alpha amylase catalytic
HLG82_RS07115	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HLG82_RS07130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HLG82_RS07135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HLG82_RS07140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HLG82_RS07145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLG82_RS07150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HLG82_RS07155	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLG82_RS07160	COG0356	it plays a direct role in the translocation of protons across the membrane
HLG82_RS07180	COG2890	protein-(glutamine-N5) methyltransferase activity
HLG82_RS07185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HLG82_RS07200	COG0083	homoserine kinase activity
HLG82_RS07205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLG82_RS07210	COG0460	homoserine dehydrogenase
HLG82_RS07215	COG0019	diaminopimelate decarboxylase activity
HLG82_RS07220	COG0018	arginyl-trna synthetase
HLG82_RS07265	COG1388	LysM domain
HLG82_RS07265	COG4942	peptidase
HLG82_RS07275	COG1253	flavin adenine dinucleotide binding
HLG82_RS07280	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG82_RS07280	COG0567	Dehydrogenase, E1 component
HLG82_RS07290	COG0791	NLP P60 protein
HLG82_RS07290	COG1388	LysM domain
HLG82_RS07290	COG3103	Sh3 type 3 domain protein
HLG82_RS07300	COG1595	DNA-templated transcription, initiation
HLG82_RS07305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLG82_RS07310	COG0363	glucosamine-6-phosphate deaminase activity
HLG82_RS07315	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HLG82_RS07320	COG1940	carbohydrate kinase activity
HLG82_RS07320	COG1846	Transcriptional regulator
HLG82_RS07325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG82_RS07330	COG4608	Belongs to the ABC transporter superfamily
HLG82_RS07335	COG0444	Belongs to the ABC transporter superfamily
HLG82_RS07340	COG0601	transmembrane transport
HLG82_RS07345	COG0747	negative chemotaxis
HLG82_RS07355	COG0657	acetylesterase activity
HLG82_RS07370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLG82_RS07380	COG0483	inositol monophosphate 1-phosphatase activity
HLG82_RS07385	COG0420	3'-5' exonuclease activity
HLG82_RS07390	COG0419	ATPase involved in DNA repair
HLG82_RS07430	COG0653	protein targeting
HLG82_RS07435	COG0142	geranyltranstransferase activity
HLG82_RS07440	COG1007	ATP synthesis coupled electron transport
HLG82_RS07450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLG82_RS07455	COG0713	ATP synthesis coupled electron transport
HLG82_RS07465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG82_RS07470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HLG82_RS07475	COG1034	ATP synthesis coupled electron transport
HLG82_RS07480	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HLG82_RS07490	COG0649	NAD binding
HLG82_RS07495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG82_RS07500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG82_RS07510	COG0644	oxidoreductase
HLG82_RS07515	COG2226	methyltransferase
HLG82_RS07530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HLG82_RS07535	COG4948	Mandelate Racemase Muconate Lactonizing
HLG82_RS07540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLG82_RS07545	COG1653	transport
HLG82_RS07550	COG1177	transmembrane transport
HLG82_RS07555	COG0395	ABC-type sugar transport system, permease component
HLG82_RS07580	COG0406	alpha-ribazole phosphatase activity
HLG82_RS07600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLG82_RS07605	COG0569	domain protein
HLG82_RS07610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLG82_RS07620	COG1194	a g-specific adenine glycosylase
HLG82_RS07630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HLG82_RS07635	COG2390	Transcriptional regulator
HLG82_RS07640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLG82_RS07650	COG0247	lactate metabolic process
HLG82_RS07665	COG1131	(ABC) transporter
HLG82_RS07680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLG82_RS07685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLG82_RS07690	COG2409	Drug exporters of the RND superfamily
HLG82_RS07695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLG82_RS07705	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HLG82_RS07710	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HLG82_RS07720	COG2376	Dihydroxyacetone kinase
HLG82_RS07725	COG1461	Dihydroxyacetone kinase
HLG82_RS07730	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLG82_RS07730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLG82_RS07735	COG3250	beta-galactosidase activity
HLG82_RS07755	COG1609	Transcriptional regulator
HLG82_RS07775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLG82_RS07780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLG82_RS07785	COG0302	gtp cyclohydrolase
HLG82_RS07790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLG82_RS07795	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HLG82_RS07800	COG0037	tRNA processing
HLG82_RS07815	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HLG82_RS07820	COG0791	NLP P60 protein
HLG82_RS07825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG82_RS07830	COG2267	carboxylic ester hydrolase activity
HLG82_RS07840	COG0247	lactate metabolic process
HLG82_RS07840	COG0277	FAD linked oxidase domain protein
HLG82_RS07870	COG0574	Belongs to the PEP-utilizing enzyme family
HLG82_RS07870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLG82_RS07875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG82_RS07900	COG0464	growth
HLG82_RS07920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HLG82_RS07975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLG82_RS07975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLG82_RS07980	COG3617	BRO family, N-terminal domain
HLG82_RS08020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLG82_RS08050	COG1802	Transcriptional regulator
HLG82_RS08050	COG4626	Terminase
HLG82_RS08055	COG4695	Portal protein
HLG82_RS08060	COG0740	serine-type endopeptidase activity
HLG82_RS08130	COG4824	toxin secretion phage lysis holin
HLG82_RS08140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLG82_RS08165	COG1715	Restriction endonuclease
HLG82_RS08175	COG3177	Filamentation induced by cAMP protein fic
HLG82_RS08190	COG1252	NADH dehydrogenase
HLG82_RS08195	COG3119	arylsulfatase activity
HLG82_RS08200	COG1609	Transcriptional regulator
HLG82_RS08205	COG2271	Major facilitator Superfamily
HLG82_RS08210	COG0641	radical SAM
HLG82_RS08215	COG0730	response to heat
HLG82_RS08240	COG2226	methyltransferase
HLG82_RS08245	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_RS08255	COG3250	beta-galactosidase activity
HLG82_RS08275	COG0698	ribose 5-phosphate isomerase
HLG82_RS08280	COG1063	alcohol dehydrogenase
HLG82_RS08285	COG2376	Dihydroxyacetone kinase
HLG82_RS08310	COG1070	Carbohydrate kinase
HLG82_RS08315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLG82_RS08325	COG2390	Transcriptional regulator
HLG82_RS08330	COG0738	Major facilitator superfamily
HLG82_RS08350	COG1490	D-aminoacyl-tRNA deacylase activity
HLG82_RS08370	COG3485	protocatechuate 3,4-dioxygenase
HLG82_RS08380	COG1115	amino acid carrier protein
HLG82_RS08390	COG0306	phosphate transporter
HLG82_RS08395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLG82_RS08410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLG82_RS08415	COG0494	nUDIX hydrolase
HLG82_RS08415	COG0406	alpha-ribazole phosphatase activity
HLG82_RS08420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HLG82_RS08445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLG82_RS08475	COG2348	transferase activity, transferring amino-acyl groups
HLG82_RS08480	COG2348	transferase activity, transferring amino-acyl groups
HLG82_RS08495	COG0039	L-malate dehydrogenase activity
HLG82_RS08530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG82_RS08555	COG0557	exoribonuclease II activity
HLG82_RS08565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLG82_RS08580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLG82_RS08585	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HLG82_RS08590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLG82_RS08600	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_RS08605	COG0191	fructose-bisphosphate aldolase activity
HLG82_RS08625	COG0494	nUDIX hydrolase
HLG82_RS08680	COG2826	transposase and inactivated derivatives, IS30 family
HLG82_RS08685	COG3949	Membrane
HLG82_RS08690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLG82_RS08705	COG0823	Involved in the tonB-independent uptake of proteins
HLG82_RS08705	COG1506	peptidase
HLG82_RS08710	COG0584	glycerophosphoryl diester phosphodiesterase
HLG82_RS08720	COG0789	Transcriptional regulator
HLG82_RS08725	COG0484	heat shock protein binding
HLG82_RS08730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLG82_RS08735	COG0443	Heat shock 70 kDa protein
HLG82_RS08740	COG0167	dihydroorotate dehydrogenase activity
HLG82_RS08755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HLG82_RS08760	COG0284	orotidine-5'-phosphate decarboxylase activity
HLG82_RS08765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLG82_RS08770	COG0540	Belongs to the ATCase OTCase family
HLG82_RS08775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HLG82_RS08790	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG82_RS08795	COG1937	Protein conserved in bacteria
HLG82_RS08800	COG0243	molybdopterin cofactor binding
HLG82_RS08805	COG0437	4 iron, 4 sulfur cluster binding
HLG82_RS08825	COG1505	serine-type exopeptidase activity
HLG82_RS08835	COG0390	transport system, permease component
HLG82_RS08840	COG1940	carbohydrate kinase activity
HLG82_RS08880	COG0662	Cupin 2, conserved barrel domain protein
HLG82_RS08905	COG3842	ATPase activity
HLG82_RS08915	COG4143	(ABC) transporter
HLG82_RS08940	COG0651	ATP synthesis coupled electron transport
HLG82_RS08945	COG1006	Multisubunit Na H antiporter MnhC subunit
HLG82_RS08950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLG82_RS08950	COG2111	Na H antiporter
HLG82_RS08955	COG0717	Belongs to the dCTP deaminase family
HLG82_RS08970	COG3177	Filamentation induced by cAMP protein fic
HLG82_RS08980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HLG82_RS08990	COG3345	alpha-galactosidase
HLG82_RS09015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HLG82_RS09020	COG0667	Aldo Keto reductase
HLG82_RS09040	COG0710	3-dehydroquinate dehydratase activity
HLG82_RS09070	COG0714	Associated with various cellular activities
HLG82_RS09085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLG82_RS09090	COG1950	PFAM Membrane protein of
HLG82_RS09095	COG3001	Fructosamine kinase
HLG82_RS09100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLG82_RS09105	COG0586	Pfam SNARE associated Golgi protein
HLG82_RS09120	COG2217	Heavy metal translocating P-type atpase
HLG82_RS09135	COG4604	ABC transporter, ATP-binding protein
HLG82_RS09145	COG2814	Major facilitator Superfamily
HLG82_RS09155	COG0673	inositol 2-dehydrogenase activity
HLG82_RS09160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLG82_RS09180	COG3718	enzyme involved in inositol metabolism
HLG82_RS09185	COG3962	Belongs to the TPP enzyme family
HLG82_RS09195	COG4604	ABC transporter, ATP-binding protein
HLG82_RS09200	COG4605	iron ion homeostasis
HLG82_RS09215	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HLG82_RS09235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLG82_RS09240	COG1904	glucuronate isomerase
HLG82_RS09255	COG3971	2-oxopent-4-enoate hydratase activity
HLG82_RS09265	COG1802	Transcriptional regulator
HLG82_RS09270	COG0477	Major facilitator Superfamily
HLG82_RS09280	COG1012	belongs to the aldehyde dehydrogenase family
HLG82_RS09285	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLG82_RS09305	COG3142	Participates in the control of copper homeostasis
HLG82_RS09320	COG1940	carbohydrate kinase activity
HLG82_RS09330	COG0601	transmembrane transport
HLG82_RS09335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG82_RS09345	COG1940	carbohydrate kinase activity
HLG82_RS09350	COG1846	Transcriptional regulator
HLG82_RS09350	COG1940	carbohydrate kinase activity
HLG82_RS09360	COG1175	transmembrane transport
HLG82_RS09390	COG1486	melibiose metabolic process
HLG82_RS09395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLG82_RS09395	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HLG82_RS09400	COG1879	ABC-type sugar transport system periplasmic component
HLG82_RS09405	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLG82_RS09415	COG2188	Transcriptional regulator
HLG82_RS09440	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HLG82_RS09455	COG0395	ABC-type sugar transport system, permease component
HLG82_RS09460	COG1175	transmembrane transport
HLG82_RS09475	COG1609	Transcriptional regulator
HLG82_RS09480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLG82_RS09485	COG0800	Aldolase
HLG82_RS09490	COG1312	Catalyzes the dehydration of D-mannonate
HLG82_RS09495	COG0246	Mannitol dehydrogenase
HLG82_RS09500	COG1414	Transcriptional regulator
HLG82_RS09515	COG1328	CTP reductase activity
HLG82_RS09530	COG2197	response regulator
HLG82_RS09540	COG1136	(ABC) transporter
HLG82_RS09550	COG2197	response regulator
HLG82_RS09555	COG1643	Atp-dependent helicase
HLG82_RS09575	COG1175	transmembrane transport
HLG82_RS09580	COG0395	ABC-type sugar transport system, permease component
HLG82_RS09585	COG1653	transport
HLG82_RS09615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLG82_RS09625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLG82_RS09630	COG3253	May function as heme-dependent peroxidase
HLG82_RS09635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HLG82_RS09640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLG82_RS09645	COG1780	Probably involved in ribonucleotide reductase function
HLG82_RS09660	COG1854	S-ribosylhomocysteine lyase activity
HLG82_RS09665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLG82_RS09700	COG1131	(ABC) transporter
HLG82_RS09700	COG0842	Transport permease protein
HLG82_RS09700	COG1716	ATPase activity
HLG82_RS09720	COG0768	penicillin binding
HLG82_RS09735	COG3764	Sortase (surface protein transpeptidase)
HLG82_RS09790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLG82_RS09795	COG0187	DNA topoisomerase II activity
HLG82_RS09800	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HLG82_RS09805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLG82_RS09815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HLG82_RS09820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HLG82_RS09825	COG0594	ribonuclease P activity
HLG82_RS09830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HLG82_RS09835	COG0706	membrane insertase activity
HLG82_RS09845	COG0357	Ribosomal RNA small subunit methyltransferase G
HLG82_RS09860	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLG82_RS09865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG82_RS09870	COG0492	ferredoxin-NADP+ reductase activity
HLG82_RS09900	COG0628	permease
HLG82_RS09905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLG82_RS09910	COG0360	Binds together with S18 to 16S ribosomal RNA
HLG82_RS09920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HLG82_RS09925	COG0359	binds to the 23S rRNA
HLG82_RS09945	COG0305	Participates in initiation and elongation during chromosome replication
HLG82_RS09955	COG0084	hydrolase, TatD family'
HLG82_RS09960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLG82_RS09975	COG0351	phosphomethylpyrimidine kinase
HLG82_RS09980	COG0656	L-ascorbic acid biosynthetic process
HLG82_RS10020	COG1428	Deoxynucleoside kinase
HLG82_RS10030	COG0343	queuine tRNA-ribosyltransferase activity
HLG82_RS10035	COG2205	protein histidine kinase activity
HLG82_RS10040	COG0745	RESPONSE REGULATOR receiver
HLG82_RS10055	COG0577	efflux transmembrane transporter activity
HLG82_RS10055	COG1136	(ABC) transporter
HLG82_RS10060	COG0577	efflux transmembrane transporter activity
HLG82_RS10060	COG1136	(ABC) transporter
HLG82_RS10080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLG82_RS10085	COG0569	domain protein
HLG82_RS10095	COG1643	Atp-dependent helicase
HLG82_RS10110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLG82_RS10160	COG1518	maintenance of DNA repeat elements
HLG82_RS10170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLG82_RS10200	COG0471	metal ion transport
HLG82_RS10225	COG0561	phosphatase activity
HLG82_RS10230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HLG82_RS10240	COG0077	Prephenate dehydratase
HLG82_RS10250	COG1215	transferase activity, transferring glycosyl groups
HLG82_RS10265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLG82_RS10270	COG0590	tRNA wobble adenosine to inosine editing
HLG82_RS10280	COG1114	Component of the transport system for branched-chain amino acids
HLG82_RS10285	COG4868	Belongs to the UPF0371 family
HLG82_RS10290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLG82_RS10345	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLG82_RS10355	COG0315	cyclic pyranopterin monophosphate synthase activity
HLG82_RS10365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate