locus-tag	class	description
INS88_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INS88_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INS88_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
INS88_RS00025	COG0187	DNA topoisomerase II activity
INS88_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INS88_RS00085	COG3764	Sortase (surface protein transpeptidase)
INS88_RS00100	COG0768	penicillin binding
INS88_RS00120	COG0842	Transport permease protein
INS88_RS00120	COG1716	ATPase activity
INS88_RS00120	COG1131	(ABC) transporter
INS88_RS00155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INS88_RS00160	COG1854	S-ribosylhomocysteine lyase activity
INS88_RS00175	COG1780	Probably involved in ribonucleotide reductase function
INS88_RS00180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INS88_RS00190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
INS88_RS00200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INS88_RS00230	COG1653	transport
INS88_RS00235	COG0395	ABC-type sugar transport system, permease component
INS88_RS00240	COG1175	transmembrane transport
INS88_RS00260	COG1643	Atp-dependent helicase
INS88_RS00265	COG2197	response regulator
INS88_RS00275	COG1136	(ABC) transporter
INS88_RS00285	COG2197	response regulator
INS88_RS00300	COG1328	CTP reductase activity
INS88_RS00315	COG1414	Transcriptional regulator
INS88_RS00320	COG0246	Mannitol dehydrogenase
INS88_RS00325	COG1312	Catalyzes the dehydration of D-mannonate
INS88_RS00330	COG0800	Aldolase
INS88_RS00335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INS88_RS00340	COG1609	Transcriptional regulator
INS88_RS00355	COG1175	transmembrane transport
INS88_RS00360	COG0395	ABC-type sugar transport system, permease component
INS88_RS00370	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INS88_RS00395	COG2188	Transcriptional regulator
INS88_RS00405	COG1172	Belongs to the binding-protein-dependent transport system permease family
INS88_RS00410	COG1879	ABC-type sugar transport system periplasmic component
INS88_RS00415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
INS88_RS00415	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
INS88_RS00420	COG1486	melibiose metabolic process
INS88_RS00450	COG1175	transmembrane transport
INS88_RS00460	COG1846	Transcriptional regulator
INS88_RS00460	COG1940	carbohydrate kinase activity
INS88_RS00465	COG1940	carbohydrate kinase activity
INS88_RS00475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
INS88_RS00480	COG0601	transmembrane transport
INS88_RS00490	COG1940	carbohydrate kinase activity
INS88_RS00505	COG3142	Participates in the control of copper homeostasis
INS88_RS00525	COG0179	Fumarylacetoacetate (FAA) hydrolase
INS88_RS00530	COG1012	belongs to the aldehyde dehydrogenase family
INS88_RS00540	COG0477	Major facilitator Superfamily
INS88_RS00545	COG1802	Transcriptional regulator
INS88_RS00555	COG3971	2-oxopent-4-enoate hydratase activity
INS88_RS00570	COG1904	glucuronate isomerase
INS88_RS00575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
INS88_RS00595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INS88_RS00610	COG4605	iron ion homeostasis
INS88_RS00615	COG4604	ABC transporter, ATP-binding protein
INS88_RS00625	COG3962	Belongs to the TPP enzyme family
INS88_RS00630	COG3718	enzyme involved in inositol metabolism
INS88_RS00650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INS88_RS00655	COG0673	inositol 2-dehydrogenase activity
INS88_RS00665	COG2814	Major facilitator Superfamily
INS88_RS00675	COG4604	ABC transporter, ATP-binding protein
INS88_RS00690	COG2217	Heavy metal translocating P-type atpase
INS88_RS00705	COG0586	Pfam SNARE associated Golgi protein
INS88_RS00710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
INS88_RS00715	COG3001	Fructosamine kinase
INS88_RS00720	COG1950	PFAM Membrane protein of
INS88_RS00725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INS88_RS00740	COG0714	Associated with various cellular activities
INS88_RS00770	COG0710	3-dehydroquinate dehydratase activity
INS88_RS00790	COG0667	Aldo Keto reductase
INS88_RS00795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INS88_RS00865	COG1802	Transcriptional regulator
INS88_RS00865	COG4626	Terminase
INS88_RS00910	COG3177	Filamentation induced by cAMP protein fic
INS88_RS00930	COG0717	Belongs to the dCTP deaminase family
INS88_RS00935	COG2111	Na H antiporter
INS88_RS00935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INS88_RS00940	COG1006	Multisubunit Na H antiporter MnhC subunit
INS88_RS00945	COG0651	ATP synthesis coupled electron transport
INS88_RS00955	COG2212	antiporter activity
INS88_RS00970	COG4143	(ABC) transporter
INS88_RS00980	COG3842	ATPase activity
INS88_RS01005	COG0662	Cupin 2, conserved barrel domain protein
INS88_RS01015	COG1940	carbohydrate kinase activity
INS88_RS01020	COG0390	transport system, permease component
INS88_RS01030	COG1505	serine-type exopeptidase activity
INS88_RS01040	COG0437	4 iron, 4 sulfur cluster binding
INS88_RS01045	COG0243	molybdopterin cofactor binding
INS88_RS01050	COG1937	Protein conserved in bacteria
INS88_RS01055	COG0446	pyridine nucleotide-disulphide oxidoreductase
INS88_RS01070	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
INS88_RS01075	COG0540	Belongs to the ATCase OTCase family
INS88_RS01080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INS88_RS01085	COG0284	orotidine-5'-phosphate decarboxylase activity
INS88_RS01090	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INS88_RS01105	COG0167	dihydroorotate dehydrogenase activity
INS88_RS01110	COG0443	Heat shock 70 kDa protein
INS88_RS01115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INS88_RS01120	COG0484	heat shock protein binding
INS88_RS01125	COG0789	Transcriptional regulator
INS88_RS01135	COG0584	glycerophosphoryl diester phosphodiesterase
INS88_RS01140	COG0823	Involved in the tonB-independent uptake of proteins
INS88_RS01140	COG1506	peptidase
INS88_RS01155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INS88_RS01160	COG3949	Membrane
INS88_RS01215	COG0494	nUDIX hydrolase
INS88_RS01235	COG0191	fructose-bisphosphate aldolase activity
INS88_RS01240	COG2826	transposase and inactivated derivatives, IS30 family
INS88_RS01250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INS88_RS01255	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
INS88_RS01260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INS88_RS01275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INS88_RS01285	COG0557	exoribonuclease II activity
INS88_RS01310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INS88_RS01350	COG0039	L-malate dehydrogenase activity
INS88_RS01365	COG2348	transferase activity, transferring amino-acyl groups
INS88_RS01400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INS88_RS01425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INS88_RS01430	COG0494	nUDIX hydrolase
INS88_RS01430	COG0406	alpha-ribazole phosphatase activity
INS88_RS01435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
INS88_RS01450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INS88_RS01455	COG0306	phosphate transporter
INS88_RS01465	COG1115	amino acid carrier protein
INS88_RS01475	COG3485	protocatechuate 3,4-dioxygenase
INS88_RS01495	COG1490	D-aminoacyl-tRNA deacylase activity
INS88_RS01505	COG1063	alcohol dehydrogenase
INS88_RS01510	COG2610	gluconate transmembrane transporter activity
INS88_RS01515	COG0246	Mannitol dehydrogenase
INS88_RS01525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INS88_RS01540	COG0738	Major facilitator superfamily
INS88_RS01545	COG2390	Transcriptional regulator
INS88_RS01555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
INS88_RS01560	COG1070	Carbohydrate kinase
INS88_RS01585	COG2376	Dihydroxyacetone kinase
INS88_RS01595	COG0698	ribose 5-phosphate isomerase
INS88_RS01620	COG3547	Transposase (IS116 IS110 IS902 family)
INS88_RS01625	COG3250	beta-galactosidase activity
INS88_RS01635	COG2226	methyltransferase
INS88_RS01655	COG0730	response to heat
INS88_RS01660	COG0641	radical SAM
INS88_RS01665	COG2271	Major facilitator Superfamily
INS88_RS01670	COG1609	Transcriptional regulator
INS88_RS01675	COG3119	arylsulfatase activity
INS88_RS01680	COG1252	NADH dehydrogenase
INS88_RS01690	COG1609	Transcriptional regulator
INS88_RS01700	COG3250	beta-galactosidase activity
INS88_RS01715	COG1175	transmembrane transport
INS88_RS01720	COG0395	ABC-type sugar transport system, permease component
INS88_RS01730	COG1715	Restriction endonuclease
INS88_RS01750	COG2963	transposase activity
INS88_RS01755	COG3421	Type III restriction
INS88_RS01760	COG2189	Belongs to the N(4) N(6)-methyltransferase family
INS88_RS01820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INS88_RS01825	COG0574	Belongs to the PEP-utilizing enzyme family
INS88_RS01825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS88_RS01840	COG0366	Alpha amylase catalytic
INS88_RS01845	COG0395	ABC-type sugar transport system, permease component
INS88_RS01850	COG1175	transmembrane transport
INS88_RS01880	COG0247	lactate metabolic process
INS88_RS01880	COG0277	FAD linked oxidase domain protein
INS88_RS01890	COG2267	carboxylic ester hydrolase activity
INS88_RS01895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
INS88_RS01900	COG0791	NLP P60 protein
INS88_RS01905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
INS88_RS01920	COG0037	tRNA processing
INS88_RS01925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INS88_RS01930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INS88_RS01935	COG0302	gtp cyclohydrolase
INS88_RS01940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INS88_RS01945	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INS88_RS01965	COG1609	Transcriptional regulator
INS88_RS01985	COG3250	beta-galactosidase activity
INS88_RS01990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS88_RS01990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
INS88_RS01995	COG1461	Dihydroxyacetone kinase
INS88_RS02000	COG2376	Dihydroxyacetone kinase
INS88_RS02010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INS88_RS02015	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INS88_RS02025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INS88_RS02030	COG2409	Drug exporters of the RND superfamily
INS88_RS02035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INS88_RS02040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
INS88_RS02055	COG1131	(ABC) transporter
INS88_RS02070	COG0247	lactate metabolic process
INS88_RS02080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
INS88_RS02085	COG2390	Transcriptional regulator
INS88_RS02090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
INS88_RS02100	COG1194	a g-specific adenine glycosylase
INS88_RS02110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INS88_RS02115	COG0569	domain protein
INS88_RS02120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INS88_RS02140	COG0406	alpha-ribazole phosphatase activity
INS88_RS02165	COG0395	ABC-type sugar transport system, permease component
INS88_RS02170	COG1177	transmembrane transport
INS88_RS02175	COG1653	transport
INS88_RS02180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
INS88_RS02185	COG4948	Mandelate Racemase Muconate Lactonizing
INS88_RS02190	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INS88_RS02205	COG2226	methyltransferase
INS88_RS02210	COG0644	oxidoreductase
INS88_RS02220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS88_RS02225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS88_RS02230	COG0649	NAD binding
INS88_RS02240	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
INS88_RS02245	COG1034	ATP synthesis coupled electron transport
INS88_RS02250	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
INS88_RS02255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS88_RS02265	COG0713	ATP synthesis coupled electron transport
INS88_RS02270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INS88_RS02280	COG1007	ATP synthesis coupled electron transport
INS88_RS02285	COG0142	geranyltranstransferase activity
INS88_RS02290	COG0653	protein targeting
INS88_RS02330	COG0419	ATPase involved in DNA repair
INS88_RS02335	COG0420	3'-5' exonuclease activity
INS88_RS02340	COG0483	inositol monophosphate 1-phosphatase activity
INS88_RS02350	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INS88_RS02365	COG0657	acetylesterase activity
INS88_RS02375	COG0747	negative chemotaxis
INS88_RS02380	COG0601	transmembrane transport
INS88_RS02385	COG0444	Belongs to the ABC transporter superfamily
INS88_RS02390	COG4608	Belongs to the ABC transporter superfamily
INS88_RS02395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INS88_RS02400	COG1940	carbohydrate kinase activity
INS88_RS02400	COG1846	Transcriptional regulator
INS88_RS02405	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
INS88_RS02410	COG0363	glucosamine-6-phosphate deaminase activity
INS88_RS02415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
INS88_RS02420	COG1595	DNA-templated transcription, initiation
INS88_RS02430	COG0791	NLP P60 protein
INS88_RS02430	COG3103	Sh3 type 3 domain protein
INS88_RS02430	COG1388	LysM domain
INS88_RS02440	COG0567	Dehydrogenase, E1 component
INS88_RS02440	COG0508	dehydrogenase complex catalyzes the overall conversion of
INS88_RS02445	COG1253	flavin adenine dinucleotide binding
INS88_RS02455	COG4942	peptidase
INS88_RS02455	COG1388	LysM domain
INS88_RS02485	COG3547	Transposase (IS116 IS110 IS902 family)
INS88_RS02490	COG2826	transposase and inactivated derivatives, IS30 family
INS88_RS02495	COG2963	transposase activity
INS88_RS02510	COG2801	Transposase and inactivated derivatives
INS88_RS02535	COG0018	arginyl-trna synthetase
INS88_RS02540	COG0019	diaminopimelate decarboxylase activity
INS88_RS02545	COG0460	homoserine dehydrogenase
INS88_RS02550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INS88_RS02555	COG0083	homoserine kinase activity
INS88_RS02570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INS88_RS02575	COG2890	protein-(glutamine-N5) methyltransferase activity
INS88_RS02595	COG0356	it plays a direct role in the translocation of protons across the membrane
INS88_RS02600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INS88_RS02605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INS88_RS02610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INS88_RS02615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INS88_RS02620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INS88_RS02625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INS88_RS02640	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
INS88_RS02675	COG0366	Alpha amylase catalytic
INS88_RS02690	COG1175	transmembrane transport
INS88_RS02695	COG3833	ABC-type maltose transport systems, permease component
INS88_RS02710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INS88_RS02725	COG0366	Alpha amylase catalytic
INS88_RS02735	COG0058	SHG alpha-glucan phosphorylase activity
INS88_RS02740	COG0180	Tryptophanyl-tRNA synthetase
INS88_RS02770	COG3480	Lon protease (S16) C-terminal proteolytic domain
INS88_RS02780	COG1615	UPF0182 protein
INS88_RS02785	COG1470	cell adhesion involved in biofilm formation
INS88_RS02785	COG0366	Alpha amylase catalytic
INS88_RS02810	COG3547	Transposase (IS116 IS110 IS902 family)
INS88_RS02820	COG1725	Transcriptional regulator
INS88_RS02825	COG1131	(ABC) transporter
INS88_RS02835	COG0387	Pfam Sodium calcium exchanger
INS88_RS02845	COG1053	succinate dehydrogenase
INS88_RS02850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INS88_RS02865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
INS88_RS02870	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INS88_RS02885	COG4989	oxidoreductase activity
INS88_RS02900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
INS88_RS02910	COG4585	Histidine kinase
INS88_RS02915	COG2135	peptidase activity
INS88_RS02920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INS88_RS02925	COG1404	Belongs to the peptidase S8 family
INS88_RS02935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INS88_RS02940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INS88_RS02945	COG0154	amidase activity
INS88_RS02950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INS88_RS03010	COG0129	dihydroxy-acid dehydratase activity
INS88_RS03015	COG2985	domain, Protein
INS88_RS03015	COG0569	domain protein
INS88_RS03025	COG0440	acetolactate synthase activity
INS88_RS03030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INS88_RS03050	COG0473	3-isopropylmalate dehydrogenase activity
INS88_RS03055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INS88_RS03060	COG1882	Formate acetyltransferase
INS88_RS03095	COG4750	Nucleotidyl transferase
INS88_RS03100	COG3475	LICD family
INS88_RS03105	COG1216	Glycosyl transferase, family 2
INS88_RS03105	COG1442	glycosyl transferase family 8
INS88_RS03130	COG2244	polysaccharide biosynthetic process
INS88_RS03135	COG0463	Glycosyl transferase, family 2
INS88_RS03135	COG1216	Glycosyl transferase, family 2
INS88_RS03160	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
INS88_RS03170	COG1162	GTPase activity
INS88_RS03200	COG1263	PTS System
INS88_RS03200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INS88_RS03200	COG2190	(PTS) system
INS88_RS03205	COG2818	Glycosylase
INS88_RS03220	COG2354	Protein conserved in bacteria
INS88_RS03225	COG3590	peptidase
INS88_RS03235	COG1045	serine acetyltransferase
INS88_RS03245	COG1739	Uncharacterized protein family UPF0029
INS88_RS03275	COG0393	Putative heavy-metal-binding
INS88_RS03300	COG0667	Aldo Keto reductase
INS88_RS03305	COG0544	peptidyl-prolyl cis-trans isomerase activity
INS88_RS03310	COG0740	serine-type endopeptidase activity
INS88_RS03315	COG0740	serine-type endopeptidase activity
INS88_RS03325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INS88_RS03330	COG0287	Prephenate dehydrogenase
INS88_RS03330	COG1605	Chorismate mutase
INS88_RS03350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INS88_RS03365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INS88_RS03370	COG0285	dihydrofolate synthase activity
INS88_RS03380	COG0105	UTP biosynthetic process
INS88_RS03395	COG3069	C4-dicarboxylate transmembrane transporter activity
INS88_RS03420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
INS88_RS03430	COG1837	Belongs to the UPF0109 family
INS88_RS03435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INS88_RS03445	COG0335	large ribosomal subunit rRNA binding
INS88_RS03450	COG0681	Belongs to the peptidase S26 family
INS88_RS03455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INS88_RS03465	COG0792	nuclease activity
INS88_RS03480	COG4974	Belongs to the 'phage' integrase family
INS88_RS03490	COG2860	membrane
INS88_RS03495	COG0052	Belongs to the universal ribosomal protein uS2 family
INS88_RS03500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INS88_RS03510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INS88_RS03515	COG0644	oxidoreductase
INS88_RS03535	COG0528	UMP kinase activity
INS88_RS03540	COG0233	cytoplasmic translational termination
INS88_RS03550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INS88_RS03560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INS88_RS03565	COG0750	zinc metalloprotease
INS88_RS03570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INS88_RS03580	COG0442	prolyl-tRNA aminoacylation
INS88_RS03590	COG0779	Required for maturation of 30S ribosomal subunits
INS88_RS03605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INS88_RS03610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INS88_RS03615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INS88_RS03620	COG5002	protein histidine kinase activity
INS88_RS03630	COG2271	Major facilitator Superfamily
INS88_RS03640	COG3842	ATPase activity
INS88_RS03670	COG1131	(ABC) transporter
INS88_RS03725	COG2963	transposase activity
INS88_RS03735	COG1185	polyribonucleotide nucleotidyltransferase activity
INS88_RS03745	COG0612	Peptidase, M16
INS88_RS03750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INS88_RS03755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INS88_RS03770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INS88_RS03775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
INS88_RS03780	COG1674	ftsk spoiiie
INS88_RS03795	COG1546	Belongs to the CinA family
INS88_RS03795	COG1058	Belongs to the CinA family
INS88_RS03800	COG1396	sequence-specific DNA binding
INS88_RS03810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
INS88_RS03815	COG2137	regulation of response to DNA damage stimulus
INS88_RS03820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INS88_RS03825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INS88_RS03830	COG2813	Specifically methylates the guanine in position
INS88_RS03835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INS88_RS03855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
INS88_RS03860	COG0318	PFAM AMP-dependent synthetase and ligase
INS88_RS03865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INS88_RS03890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
INS88_RS03900	COG2001	Belongs to the MraZ family
INS88_RS03905	COG0275	rRNA processing
INS88_RS03915	COG0768	penicillin binding
INS88_RS03920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INS88_RS03925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INS88_RS03930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INS88_RS03935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INS88_RS03945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INS88_RS03950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INS88_RS03960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INS88_RS03965	COG1496	oxidoreductase activity
INS88_RS03970	COG1799	cell septum assembly
INS88_RS03985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INS88_RS04000	COG0587	DNA-directed DNA polymerase activity
INS88_RS04005	COG2501	S4 domain
INS88_RS04020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS88_RS04025	COG1121	(ABC) transporter
INS88_RS04035	COG0423	glycine-tRNA ligase activity
INS88_RS04045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INS88_RS04060	COG0358	DNA primase activity
INS88_RS04070	COG0805	protein transport
INS88_RS04075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INS88_RS04080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INS88_RS04110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS88_RS04115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
INS88_RS04160	COG1090	epimerase
INS88_RS04180	COG0009	L-threonylcarbamoyladenylate synthase
INS88_RS04205	COG0477	Major facilitator Superfamily
INS88_RS04210	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
INS88_RS04235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INS88_RS04240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INS88_RS04245	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INS88_RS04265	COG1940	carbohydrate kinase activity
INS88_RS04280	COG0174	glutamine synthetase
INS88_RS04285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
INS88_RS04315	COG0174	glutamine synthetase
INS88_RS04335	COG0508	dehydrogenase complex catalyzes the overall conversion of
INS88_RS04340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INS88_RS04350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
INS88_RS04365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS88_RS04415	COG0205	6-phosphofructokinase activity
INS88_RS04420	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
INS88_RS04425	COG2815	serine threonine protein kinase
INS88_RS04425	COG0515	serine threonine protein kinase
INS88_RS04440	COG0142	geranyltranstransferase activity
INS88_RS04455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INS88_RS04470	COG0187	DNA topoisomerase II activity
INS88_RS04485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INS88_RS04530	COG0569	domain protein
INS88_RS04545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
INS88_RS04550	COG2826	transposase and inactivated derivatives, IS30 family
INS88_RS04555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INS88_RS04560	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
INS88_RS04620	COG2197	response regulator
INS88_RS04625	COG1760	l-serine dehydratase
INS88_RS04630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INS88_RS04635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INS88_RS04645	COG0438	transferase activity, transferring glycosyl groups
INS88_RS04665	COG0217	transcriptional regulatory protein
INS88_RS04670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INS88_RS04675	COG0632	four-way junction helicase activity
INS88_RS04680	COG2255	four-way junction helicase activity
INS88_RS04690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INS88_RS04695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INS88_RS04700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INS88_RS04705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INS88_RS04715	COG1196	nuclear chromosome segregation
INS88_RS04725	COG0124	histidyl-tRNA synthetase
INS88_RS04730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INS88_RS04735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INS88_RS04750	COG2814	Major facilitator Superfamily
INS88_RS04755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INS88_RS04770	COG2409	Drug exporters of the RND superfamily
INS88_RS04780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INS88_RS04790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INS88_RS04795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INS88_RS04815	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
INS88_RS04835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INS88_RS04840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INS88_RS04845	COG0505	Belongs to the CarA family
INS88_RS04850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INS88_RS04860	COG0194	GDP metabolic process
INS88_RS04865	COG1758	RNA polymerase activity
INS88_RS04875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INS88_RS04885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INS88_RS04895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INS88_RS04900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
INS88_RS04905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
INS88_RS04910	COG0140	phosphoribosyl-ATP diphosphatase activity
INS88_RS04915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INS88_RS04955	COG1216	Glycosyl transferase, family 2
INS88_RS04980	COG1716	ATPase activity
INS88_RS04990	COG1834	amidinotransferase
INS88_RS05000	COG0205	6-phosphofructokinase activity
INS88_RS05005	COG1160	GTP binding
INS88_RS05010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INS88_RS05020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
INS88_RS05045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INS88_RS05060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
INS88_RS05065	COG0149	triose-phosphate isomerase activity
INS88_RS05070	COG0126	phosphoglycerate kinase activity
INS88_RS05075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
INS88_RS05080	COG1481	regulation of sporulation
INS88_RS05095	COG0322	excinuclease ABC activity
INS88_RS05120	COG0556	nucleotide-excision repair
INS88_RS05125	COG0237	dephospho-CoA kinase activity
INS88_RS05130	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
INS88_RS05135	COG0539	negative regulation of cytoplasmic translation
INS88_RS05140	COG2226	methyltransferase
INS88_RS05165	COG0469	pyruvate kinase activity
INS88_RS05170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INS88_RS05180	COG0133	tryptophan synthase activity
INS88_RS05185	COG0134	indole-3-glycerol-phosphate synthase activity
INS88_RS05195	COG0107	imidazoleglycerol-phosphate synthase activity
INS88_RS05210	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
INS88_RS05220	COG4122	O-methyltransferase activity
INS88_RS05225	COG1222	aaa ATPase
INS88_RS05240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INS88_RS05245	COG1968	undecaprenyl-diphosphatase activity
INS88_RS05260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS88_RS05265	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
INS88_RS05270	COG0519	Catalyzes the synthesis of GMP from XMP
INS88_RS05275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INS88_RS05295	COG0587	DNA-directed DNA polymerase activity
INS88_RS05310	COG1881	PFAM PEBP family protein
INS88_RS05315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
INS88_RS05330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS88_RS05345	COG1119	ATPase activity
INS88_RS05350	COG0297	glycogen (starch) synthase activity
INS88_RS05360	COG0560	Phosphoserine phosphatase
INS88_RS05360	COG3830	Belongs to the UPF0237 family
INS88_RS05375	COG0488	(ABC) transporter
INS88_RS05385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INS88_RS05390	COG2151	metal-sulfur cluster biosynthetic enzyme
INS88_RS05415	COG0719	Fe-S assembly protein
INS88_RS05435	COG0728	peptidoglycan biosynthetic process
INS88_RS05455	COG0497	DNA recombination
INS88_RS05460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INS88_RS05475	COG0647	UMP catabolic process
INS88_RS05500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS88_RS05505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS88_RS05510	COG1121	(ABC) transporter
INS88_RS05520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INS88_RS05535	COG1476	TRANSCRIPTIONal
INS88_RS05540	COG0165	Argininosuccinate lyase
INS88_RS05545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INS88_RS05550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INS88_RS05560	COG0137	argininosuccinate synthase activity
INS88_RS05570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INS88_RS05575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INS88_RS05580	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
INS88_RS05585	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INS88_RS05595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INS88_RS05600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INS88_RS05620	COG1902	pentaerythritol trinitrate reductase activity
INS88_RS05625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS88_RS05640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INS88_RS05645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INS88_RS05655	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INS88_RS05660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INS88_RS05670	COG0131	Imidazoleglycerol-phosphate dehydratase
INS88_RS05680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INS88_RS05685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INS88_RS05690	COG1381	Involved in DNA repair and RecF pathway recombination
INS88_RS05695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INS88_RS05710	COG0631	protein serine/threonine phosphatase activity
INS88_RS05730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INS88_RS05745	COG0484	heat shock protein binding
INS88_RS05750	COG1420	regulation of RNA biosynthetic process
INS88_RS05770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INS88_RS05775	COG0481	GTPase activity
INS88_RS05795	COG3237	CsbD-like
INS88_RS05800	COG0268	Binds directly to 16S ribosomal RNA
INS88_RS05805	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
INS88_RS05810	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
INS88_RS05825	COG1555	photosystem II stabilization
INS88_RS05825	COG1596	polysaccharide export
INS88_RS05830	COG0433	COG0433 Predicted ATPase
INS88_RS05840	COG0495	leucyl-tRNA aminoacylation
INS88_RS05865	COG0813	purine-nucleoside phosphorylase activity
INS88_RS05870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS88_RS05870	COG1321	iron dependent repressor
INS88_RS05875	COG1435	thymidine kinase activity
INS88_RS05905	COG1121	(ABC) transporter
INS88_RS05910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS88_RS05930	COG0671	phosphoesterase, PA-phosphatase related
INS88_RS05950	COG1113	amino acid transport
INS88_RS05960	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
INS88_RS05960	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
INS88_RS05965	COG2826	transposase and inactivated derivatives, IS30 family
INS88_RS05970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
INS88_RS05975	COG2011	ABC-type metal ion transport system permease component
INS88_RS05985	COG1113	amino acid transport
INS88_RS05995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
INS88_RS06000	COG0826	peptidase U32
INS88_RS06005	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
INS88_RS06010	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
INS88_RS06015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INS88_RS06040	COG1609	Transcriptional regulator
INS88_RS06045	COG3250	beta-galactosidase activity
INS88_RS06075	COG0133	tryptophan synthase activity
INS88_RS06110	COG2801	Transposase and inactivated derivatives
INS88_RS06145	COG1136	(ABC) transporter
INS88_RS06160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INS88_RS06175	COG0406	alpha-ribazole phosphatase activity
INS88_RS06180	COG0799	negative regulation of ribosome biogenesis
INS88_RS06190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INS88_RS06195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INS88_RS06205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INS88_RS06210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INS88_RS06215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INS88_RS06220	COG1530	ribonuclease E activity
INS88_RS06225	COG1271	oxidase subunit
INS88_RS06230	COG1294	oxidase, subunit
INS88_RS06235	COG4988	ABC transporter
INS88_RS06250	COG1132	(ABC) transporter
INS88_RS06255	COG1132	(ABC) transporter
INS88_RS06275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
INS88_RS06280	COG0571	ribonuclease III activity
INS88_RS06295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INS88_RS06305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INS88_RS06310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INS88_RS06330	COG1181	Belongs to the D-alanine--D-alanine ligase family
INS88_RS06340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INS88_RS06355	COG0066	3-isopropylmalate dehydratase activity
INS88_RS06360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INS88_RS06370	COG0438	transferase activity, transferring glycosyl groups
INS88_RS06385	COG4975	Glucose uptake
INS88_RS06390	COG0339	signal peptide processing
INS88_RS06450	COG0179	Fumarylacetoacetate (FAA) hydrolase
INS88_RS06455	COG1022	Amp-dependent synthetase and ligase
INS88_RS06480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INS88_RS06485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
INS88_RS06490	COG1234	tRNA 3'-trailer cleavage
INS88_RS06495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INS88_RS06505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
INS88_RS06530	COG0569	domain protein
INS88_RS06530	COG2985	domain, Protein
INS88_RS06545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INS88_RS06560	COG0737	Belongs to the 5'-nucleotidase family
INS88_RS06580	COG0778	Nitroreductase
INS88_RS06665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS88_RS06685	COG3547	Transposase (IS116 IS110 IS902 family)
INS88_RS06700	COG2890	protein-(glutamine-N5) methyltransferase activity
INS88_RS06725	COG0352	thiamine-phosphate diphosphorylase activity
INS88_RS06730	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
INS88_RS06735	COG0477	Major facilitator Superfamily
INS88_RS06740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
INS88_RS06740	COG0352	thiamine-phosphate diphosphorylase activity
INS88_RS06740	COG0351	phosphomethylpyrimidine kinase
INS88_RS06750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INS88_RS06775	COG1619	proteins homologs of microcin C7 resistance protein MccF
INS88_RS06785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INS88_RS06790	COG0739	heme binding
INS88_RS06795	COG2177	Part of the ABC transporter FtsEX involved in
INS88_RS06800	COG2884	Cell division ATP-binding protein ftsE
INS88_RS06805	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INS88_RS06880	COG0513	Belongs to the DEAD box helicase family
INS88_RS06885	COG2095	MarC family integral membrane protein
INS88_RS06895	COG0006	proline dipeptidase activity
INS88_RS06900	COG2239	Acts as a magnesium transporter
INS88_RS06925	COG1611	Belongs to the LOG family
INS88_RS06935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INS88_RS06940	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INS88_RS06960	COG1079	Belongs to the binding-protein-dependent transport system permease family
INS88_RS06965	COG4603	Belongs to the binding-protein-dependent transport system permease family
INS88_RS06970	COG3845	ABC transporter
INS88_RS06975	COG1744	ABC transporter substrate-binding protein PnrA-like
INS88_RS06995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INS88_RS07000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INS88_RS07010	COG1268	BioY protein
INS88_RS07015	COG0736	holo-[acyl-carrier-protein] synthase activity
INS88_RS07020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INS88_RS07025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INS88_RS07030	COG4770	biotin carboxylase activity
INS88_RS07050	COG0644	oxidoreductase
INS88_RS07075	COG2271	Major facilitator Superfamily
INS88_RS07080	COG2030	dehydratase
INS88_RS07110	COG0110	maltose O-acetyltransferase activity
INS88_RS07120	COG0039	L-malate dehydrogenase activity
INS88_RS07135	COG0166	Belongs to the GPI family
INS88_RS07140	COG0205	6-phosphofructokinase activity
INS88_RS07170	COG0045	succinate-CoA ligase (ADP-forming) activity
INS88_RS07175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INS88_RS07175	COG2755	lipolytic protein G-D-S-L family
INS88_RS07185	COG5646	InterPro IPR014922
INS88_RS07205	COG0564	pseudouridine synthase activity
INS88_RS07210	COG0280	phosphate acetyltransferase
INS88_RS07210	COG0857	belongs to the CobB CobQ family
INS88_RS07215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INS88_RS07230	COG1136	(ABC) transporter
INS88_RS07240	COG0114	fumarate hydratase activity
INS88_RS07245	COG0516	GMP reductase activity
INS88_RS07265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
INS88_RS07270	COG0151	Belongs to the GarS family
INS88_RS07275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INS88_RS07280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INS88_RS07285	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INS88_RS07290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INS88_RS07295	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INS88_RS07305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INS88_RS07320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INS88_RS07325	COG0733	neurotransmitter:sodium symporter activity
INS88_RS07335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INS88_RS07340	COG1053	succinate dehydrogenase
INS88_RS07365	COG0802	atpase or kinase
INS88_RS07370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INS88_RS07380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INS88_RS07385	COG1072	(Pantothenic acid kinase))
INS88_RS07395	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INS88_RS07400	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INS88_RS07410	COG4720	Psort location CytoplasmicMembrane, score
INS88_RS07415	COG1122	ATPase activity
INS88_RS07420	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
INS88_RS07435	COG0101	tRNA pseudouridine synthase activity
INS88_RS07440	COG1940	carbohydrate kinase activity
INS88_RS07450	COG0765	amino acid transport
INS88_RS07455	COG1126	abc transporter atp-binding protein
INS88_RS07460	COG0640	Transcriptional regulator
INS88_RS07470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INS88_RS07480	COG0789	Transcriptional regulator
INS88_RS07485	COG0203	ribosomal protein L17
INS88_RS07490	COG0202	RNA polymerase activity
INS88_RS07500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INS88_RS07505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INS88_RS07510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INS88_RS07515	COG0024	Methionine aminopeptidase
INS88_RS07520	COG0563	adenylate kinase activity
INS88_RS07535	COG0200	Binds to the 23S rRNA
INS88_RS07540	COG1841	ribosomal large subunit assembly
INS88_RS07545	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INS88_RS07555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INS88_RS07560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INS88_RS07565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INS88_RS07570	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INS88_RS07575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INS88_RS07580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INS88_RS07595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INS88_RS07600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INS88_RS07605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INS88_RS07610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INS88_RS07615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INS88_RS07620	COG0089	rRNA binding
INS88_RS07625	COG0088	Forms part of the polypeptide exit tunnel
INS88_RS07630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INS88_RS07635	COG0051	transcription antitermination factor activity, RNA binding
INS88_RS07645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
INS88_RS07650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INS88_RS07655	COG0049	tRNA binding
INS88_RS07660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INS88_RS07665	COG0833	amino acid
INS88_RS07670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INS88_RS07675	COG0085	RNA polymerase activity
INS88_RS07680	COG0222	ribosome binding
INS88_RS07685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INS88_RS07690	COG0572	uridine kinase
INS88_RS07695	COG0081	regulation of translation
INS88_RS07700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INS88_RS07720	COG0436	Aminotransferase
INS88_RS07730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
INS88_RS07745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
INS88_RS07750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INS88_RS07770	COG1666	GTP binding
INS88_RS07780	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
INS88_RS07790	COG5401	PFAM Sporulation and spore germination
INS88_RS07795	COG5002	protein histidine kinase activity
INS88_RS07800	COG0745	RESPONSE REGULATOR receiver
INS88_RS07820	COG0714	Associated with various cellular activities
INS88_RS07865	COG0483	inositol monophosphate 1-phosphatase activity
INS88_RS07880	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INS88_RS07920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INS88_RS07960	COG0438	transferase activity, transferring glycosyl groups
INS88_RS07970	COG0673	inositol 2-dehydrogenase activity
INS88_RS07980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INS88_RS07995	COG1088	dTDP-glucose 4,6-dehydratase activity
INS88_RS08015	COG1316	TRANSCRIPTIONal
INS88_RS08025	COG0642	Histidine kinase
INS88_RS08030	COG0745	RESPONSE REGULATOR receiver
INS88_RS08045	COG0424	maF-like protein
INS88_RS08080	COG1217	gtp-binding protein TYPA
INS88_RS08090	COG1132	(ABC) transporter
INS88_RS08095	COG1132	(ABC) transporter
INS88_RS08120	COG0321	lipoyl(octanoyl) transferase activity
INS88_RS08125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INS88_RS08135	COG1362	aminopeptidase activity
INS88_RS08150	COG2838	Isocitrate dehydrogenase
INS88_RS08155	COG2391	methyltransferase activity
INS88_RS08160	COG0425	Belongs to the sulfur carrier protein TusA family
INS88_RS08180	COG2116	formate transmembrane transporter activity
INS88_RS08190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INS88_RS08200	COG0242	peptide deformylase activity
INS88_RS08205	COG1970	mechanosensitive ion channel activity
INS88_RS08220	COG1174	glycine betaine transport
INS88_RS08235	COG0778	Nitroreductase
INS88_RS08260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INS88_RS08260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
INS88_RS08310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INS88_RS08375	COG4824	toxin secretion phage lysis holin
INS88_RS08445	COG0740	serine-type endopeptidase activity
INS88_RS08450	COG4695	Portal protein
INS88_RS08465	COG4626	Terminase
INS88_RS08465	COG1802	Transcriptional regulator
INS88_RS08550	COG0012	GTP binding
INS88_RS08555	COG1322	Protein conserved in bacteria
INS88_RS08560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INS88_RS08565	COG1570	exodeoxyribonuclease VII activity
INS88_RS08570	COG1722	exodeoxyribonuclease VII activity
INS88_RS08575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INS88_RS08580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INS88_RS08590	COG2326	polyphosphate kinase activity
INS88_RS08595	COG2326	polyphosphate kinase activity
INS88_RS08600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
INS88_RS08605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INS88_RS08610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INS88_RS08620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INS88_RS08625	COG1012	belongs to the aldehyde dehydrogenase family
INS88_RS08640	COG1131	(ABC) transporter
INS88_RS08670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INS88_RS08695	COG0148	phosphopyruvate hydratase activity
INS88_RS08710	COG0193	aminoacyl-tRNA hydrolase activity
INS88_RS08720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INS88_RS08725	COG1136	(ABC) transporter
INS88_RS08735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INS88_RS08750	COG4152	abc transporter atp-binding protein
INS88_RS08755	COG1668	transmembrane transport
INS88_RS08765	COG0488	(ABC) transporter
INS88_RS08770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
INS88_RS08775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INS88_RS08785	COG0084	hydrolase, TatD family'
INS88_RS08790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INS88_RS08800	COG1335	isochorismatase
INS88_RS08820	COG2873	o-acetylhomoserine
INS88_RS08830	COG1131	(ABC) transporter
INS88_RS08845	COG2813	Specifically methylates the guanine in position
INS88_RS08850	COG0667	Aldo Keto reductase
INS88_RS08855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INS88_RS08870	COG1120	ATPase activity
INS88_RS08875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS88_RS08885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INS88_RS08910	COG1620	l-lactate permease
INS88_RS08915	COG0247	lactate metabolic process
INS88_RS08925	COG1556	Lactate utilization protein
INS88_RS08945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
INS88_RS08955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INS88_RS08955	COG1263	PTS System
INS88_RS08970	COG1131	(ABC) transporter
INS88_RS08975	COG1051	belongs to the nudix hydrolase family
INS88_RS08985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS88_RS09010	COG1511	domain protein
INS88_RS09020	COG2848	UPF0210 protein
INS88_RS09025	COG3830	Belongs to the UPF0237 family
INS88_RS09030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INS88_RS09035	COG0254	rRNA binding
INS88_RS09040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INS88_RS09045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INS88_RS09050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INS88_RS09055	COG0028	Belongs to the TPP enzyme family
INS88_RS09055	COG0028	Belongs to the TPP enzyme family
INS88_RS09070	COG0477	Major facilitator Superfamily
INS88_RS09075	COG0657	acetylesterase activity
INS88_RS09080	COG2188	Transcriptional regulator
INS88_RS09085	COG1120	ATPase activity
INS88_RS09090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS88_RS09095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS88_RS09100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
INS88_RS09110	COG0488	(ABC) transporter
INS88_RS09190	COG1321	iron dependent repressor
INS88_RS09200	COG2252	PERMEase
INS88_RS09205	COG1482	cell wall glycoprotein biosynthetic process
INS88_RS09215	COG1278	Cold shock
INS88_RS09225	COG1842	Phage shock protein A
INS88_RS09235	COG0745	RESPONSE REGULATOR receiver
INS88_RS09240	COG2205	protein histidine kinase activity
INS88_RS09250	COG4221	oxidoreductase activity
INS88_RS09260	COG0459	protein refolding
INS88_RS09275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INS88_RS09285	COG0395	ABC-type sugar transport system, permease component
INS88_RS09290	COG1175	transmembrane transport
INS88_RS09310	COG1609	Transcriptional regulator
INS88_RS09320	COG4974	Belongs to the 'phage' integrase family
INS88_RS09395	COG0741	lytic transglycosylase activity
INS88_RS09565	COG3842	ATPase activity
INS88_RS09580	COG1653	transport
INS88_RS09585	COG1175	transmembrane transport
INS88_RS09615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INS88_RS09655	COG2233	PERMEase
INS88_RS09670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS88_RS09675	COG0215	cysteine-tRNA ligase activity
INS88_RS09685	COG1136	(ABC) transporter
INS88_RS09700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
INS88_RS09705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INS88_RS09715	COG0745	RESPONSE REGULATOR receiver
INS88_RS09725	COG0704	Plays a role in the regulation of phosphate uptake
INS88_RS09735	COG0588	phosphoglycerate mutase activity
INS88_RS09775	COG4974	Belongs to the 'phage' integrase family
INS88_RS09785	COG1192	Involved in chromosome partitioning
INS88_RS09805	COG2184	nucleotidyltransferase activity
INS88_RS09905	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INS88_RS09910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
INS88_RS09915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INS88_RS09915	COG1754	DNA topoisomerase type I activity
INS88_RS09930	COG3655	Transcriptional regulator
INS88_RS09935	COG1205	dead DEAH box helicase
INS88_RS09935	COG1111	helicase
INS88_RS09980	COG0596	Alpha beta hydrolase
INS88_RS10010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INS88_RS10040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
INS88_RS10050	COG0315	cyclic pyranopterin monophosphate synthase activity
INS88_RS10060	COG0521	Mo-molybdopterin cofactor biosynthetic process
INS88_RS10065	COG0725	ABC transporter, periplasmic molybdate-binding protein
INS88_RS10115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INS88_RS10120	COG4868	Belongs to the UPF0371 family
INS88_RS10125	COG3547	Transposase (IS116 IS110 IS902 family)
INS88_RS10130	COG1114	Component of the transport system for branched-chain amino acids
INS88_RS10140	COG0590	tRNA wobble adenosine to inosine editing
INS88_RS10145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INS88_RS10160	COG1215	transferase activity, transferring glycosyl groups
INS88_RS10170	COG0077	Prephenate dehydratase
INS88_RS10180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INS88_RS10185	COG0561	phosphatase activity
INS88_RS10210	COG0471	metal ion transport
INS88_RS10240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INS88_RS10250	COG1518	maintenance of DNA repeat elements
INS88_RS10290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INS88_RS10305	COG1643	Atp-dependent helicase
INS88_RS10315	COG0569	domain protein
INS88_RS10320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INS88_RS10340	COG0577	efflux transmembrane transporter activity
INS88_RS10340	COG1136	(ABC) transporter
INS88_RS10345	COG1136	(ABC) transporter
INS88_RS10345	COG0577	efflux transmembrane transporter activity
INS88_RS10360	COG0745	RESPONSE REGULATOR receiver
INS88_RS10365	COG2205	protein histidine kinase activity
INS88_RS10370	COG0343	queuine tRNA-ribosyltransferase activity
INS88_RS10380	COG1428	Deoxynucleoside kinase
INS88_RS10420	COG0656	L-ascorbic acid biosynthetic process
INS88_RS10425	COG0351	phosphomethylpyrimidine kinase
INS88_RS10440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INS88_RS10445	COG0084	hydrolase, TatD family'
INS88_RS10455	COG0305	Participates in initiation and elongation during chromosome replication
INS88_RS10475	COG0359	binds to the 23S rRNA
INS88_RS10480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INS88_RS10490	COG0360	Binds together with S18 to 16S ribosomal RNA
INS88_RS10495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INS88_RS10500	COG0628	permease
INS88_RS10530	COG0492	ferredoxin-NADP+ reductase activity
INS88_RS10535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INS88_RS10540	COG1181	Belongs to the D-alanine--D-alanine ligase family
INS88_RS10555	COG0357	Ribosomal RNA small subunit methyltransferase G
INS88_RS10565	COG0706	membrane insertase activity
INS88_RS10570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INS88_RS10575	COG0594	ribonuclease P activity
INS88_RS10580	COG0230	Belongs to the bacterial ribosomal protein bL34 family