locus-tag	class	description
INS90_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INS90_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INS90_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
INS90_RS00025	COG0187	DNA topoisomerase II activity
INS90_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INS90_RS00085	COG3764	Sortase (surface protein transpeptidase)
INS90_RS00100	COG0768	penicillin binding
INS90_RS00105	COG0772	Belongs to the SEDS family
INS90_RS00120	COG0842	Transport permease protein
INS90_RS00120	COG1131	(ABC) transporter
INS90_RS00120	COG1716	ATPase activity
INS90_RS00155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INS90_RS00160	COG1854	S-ribosylhomocysteine lyase activity
INS90_RS00175	COG1780	Probably involved in ribonucleotide reductase function
INS90_RS00180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INS90_RS00185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INS90_RS00185	COG3253	May function as heme-dependent peroxidase
INS90_RS00190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
INS90_RS00200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INS90_RS00220	COG1653	transport
INS90_RS00225	COG0395	ABC-type sugar transport system, permease component
INS90_RS00230	COG1175	transmembrane transport
INS90_RS00255	COG1643	Atp-dependent helicase
INS90_RS00260	COG2197	response regulator
INS90_RS00265	COG4585	Histidine kinase
INS90_RS00275	COG1131	(ABC) transporter
INS90_RS00285	COG1136	(ABC) transporter
INS90_RS00295	COG2197	response regulator
INS90_RS00310	COG1328	CTP reductase activity
INS90_RS00325	COG1414	Transcriptional regulator
INS90_RS00330	COG0246	Mannitol dehydrogenase
INS90_RS00335	COG1312	Catalyzes the dehydration of D-mannonate
INS90_RS00340	COG0800	Aldolase
INS90_RS00345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INS90_RS00350	COG1609	Transcriptional regulator
INS90_RS00365	COG1175	transmembrane transport
INS90_RS00370	COG0395	ABC-type sugar transport system, permease component
INS90_RS00375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INS90_RS00400	COG2188	Transcriptional regulator
INS90_RS00410	COG1172	Belongs to the binding-protein-dependent transport system permease family
INS90_RS00415	COG1879	ABC-type sugar transport system periplasmic component
INS90_RS00425	COG1486	melibiose metabolic process
INS90_RS00460	COG1846	Transcriptional regulator
INS90_RS00460	COG1940	carbohydrate kinase activity
INS90_RS00465	COG1940	carbohydrate kinase activity
INS90_RS00475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
INS90_RS00480	COG0601	transmembrane transport
INS90_RS00505	COG3142	Participates in the control of copper homeostasis
INS90_RS00525	COG0179	Fumarylacetoacetate (FAA) hydrolase
INS90_RS00530	COG1012	belongs to the aldehyde dehydrogenase family
INS90_RS00540	COG0477	Major facilitator Superfamily
INS90_RS00545	COG1802	Transcriptional regulator
INS90_RS00555	COG3971	2-oxopent-4-enoate hydratase activity
INS90_RS00565	COG1904	glucuronate isomerase
INS90_RS00570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
INS90_RS00575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
INS90_RS00590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INS90_RS00600	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS90_RS00605	COG4605	iron ion homeostasis
INS90_RS00610	COG4604	ABC transporter, ATP-binding protein
INS90_RS00620	COG3962	Belongs to the TPP enzyme family
INS90_RS00625	COG3718	enzyme involved in inositol metabolism
INS90_RS00645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INS90_RS00650	COG0673	inositol 2-dehydrogenase activity
INS90_RS00660	COG2814	Major facilitator Superfamily
INS90_RS00675	COG4604	ABC transporter, ATP-binding protein
INS90_RS00710	COG0586	Pfam SNARE associated Golgi protein
INS90_RS00715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
INS90_RS00720	COG3001	Fructosamine kinase
INS90_RS00725	COG1950	PFAM Membrane protein of
INS90_RS00730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INS90_RS00745	COG0714	Associated with various cellular activities
INS90_RS00800	COG0667	Aldo Keto reductase
INS90_RS00805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INS90_RS00835	COG1129	ABC transporter
INS90_RS00845	COG1175	transmembrane transport
INS90_RS00850	COG0395	ABC-type sugar transport system, permease component
INS90_RS00860	COG3345	alpha-galactosidase
INS90_RS00880	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
INS90_RS00885	COG0477	Major facilitator Superfamily
INS90_RS00890	COG0477	Major facilitator Superfamily
INS90_RS00930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
INS90_RS00985	COG1802	Transcriptional regulator
INS90_RS00985	COG4626	Terminase
INS90_RS01045	COG3177	Filamentation induced by cAMP protein fic
INS90_RS01070	COG0717	Belongs to the dCTP deaminase family
INS90_RS01075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INS90_RS01075	COG2111	Na H antiporter
INS90_RS01080	COG1006	Multisubunit Na H antiporter MnhC subunit
INS90_RS01085	COG0651	ATP synthesis coupled electron transport
INS90_RS01095	COG2212	antiporter activity
INS90_RS01110	COG4143	(ABC) transporter
INS90_RS01115	COG4149	molybdate abc transporter
INS90_RS01120	COG3842	ATPase activity
INS90_RS01145	COG0662	Cupin 2, conserved barrel domain protein
INS90_RS01165	COG1940	carbohydrate kinase activity
INS90_RS01170	COG0390	transport system, permease component
INS90_RS01180	COG1505	serine-type exopeptidase activity
INS90_RS01190	COG0437	4 iron, 4 sulfur cluster binding
INS90_RS01195	COG0243	molybdopterin cofactor binding
INS90_RS01200	COG1937	Protein conserved in bacteria
INS90_RS01205	COG0446	pyridine nucleotide-disulphide oxidoreductase
INS90_RS01220	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
INS90_RS01225	COG0540	Belongs to the ATCase OTCase family
INS90_RS01230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INS90_RS01235	COG0284	orotidine-5'-phosphate decarboxylase activity
INS90_RS01240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INS90_RS01255	COG0167	dihydroorotate dehydrogenase activity
INS90_RS01260	COG0443	Heat shock 70 kDa protein
INS90_RS01265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INS90_RS01270	COG0484	heat shock protein binding
INS90_RS01275	COG0789	Transcriptional regulator
INS90_RS01295	COG0584	glycerophosphoryl diester phosphodiesterase
INS90_RS01300	COG1506	peptidase
INS90_RS01300	COG0823	Involved in the tonB-independent uptake of proteins
INS90_RS01315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INS90_RS01320	COG3949	Membrane
INS90_RS01375	COG0494	nUDIX hydrolase
INS90_RS01390	COG0191	fructose-bisphosphate aldolase activity
INS90_RS01400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INS90_RS01405	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
INS90_RS01410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INS90_RS01425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INS90_RS01435	COG0557	exoribonuclease II activity
INS90_RS01460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INS90_RS01495	COG0039	L-malate dehydrogenase activity
INS90_RS01510	COG2348	transferase activity, transferring amino-acyl groups
INS90_RS01515	COG2348	transferase activity, transferring amino-acyl groups
INS90_RS01550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INS90_RS01575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INS90_RS01580	COG0406	alpha-ribazole phosphatase activity
INS90_RS01580	COG0494	nUDIX hydrolase
INS90_RS01585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
INS90_RS01600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INS90_RS01605	COG0306	phosphate transporter
INS90_RS01615	COG1115	amino acid carrier protein
INS90_RS01625	COG3485	protocatechuate 3,4-dioxygenase
INS90_RS01645	COG1490	D-aminoacyl-tRNA deacylase activity
INS90_RS01665	COG0738	Major facilitator superfamily
INS90_RS01670	COG2390	Transcriptional regulator
INS90_RS01685	COG1070	Carbohydrate kinase
INS90_RS01690	COG1349	DNA-binding transcription factor activity
INS90_RS01710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INS90_RS01720	COG2376	Dihydroxyacetone kinase
INS90_RS01725	COG1063	alcohol dehydrogenase
INS90_RS01730	COG0698	ribose 5-phosphate isomerase
INS90_RS01750	COG3250	beta-galactosidase activity
INS90_RS01760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INS90_RS01765	COG1879	ABC-type sugar transport system periplasmic component
INS90_RS01770	COG1172	Belongs to the binding-protein-dependent transport system permease family
INS90_RS01775	COG1129	ABC transporter
INS90_RS01780	COG1609	Transcriptional regulator
INS90_RS01810	COG2226	methyltransferase
INS90_RS01830	COG2176	DNA-directed DNA polymerase activity
INS90_RS01845	COG1252	NADH dehydrogenase
INS90_RS01865	COG1715	Restriction endonuclease
INS90_RS01885	COG2801	Transposase and inactivated derivatives
INS90_RS01900	COG1609	Transcriptional regulator
INS90_RS01925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
INS90_RS01935	COG0574	Belongs to the PEP-utilizing enzyme family
INS90_RS01935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS90_RS01950	COG0366	Alpha amylase catalytic
INS90_RS01955	COG0395	ABC-type sugar transport system, permease component
INS90_RS01960	COG1175	transmembrane transport
INS90_RS01995	COG0247	lactate metabolic process
INS90_RS01995	COG0277	FAD linked oxidase domain protein
INS90_RS02005	COG2267	carboxylic ester hydrolase activity
INS90_RS02010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
INS90_RS02015	COG0791	NLP P60 protein
INS90_RS02020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
INS90_RS02035	COG0037	tRNA processing
INS90_RS02040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INS90_RS02045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INS90_RS02050	COG0302	gtp cyclohydrolase
INS90_RS02055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INS90_RS02060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
INS90_RS02080	COG1609	Transcriptional regulator
INS90_RS02100	COG3250	beta-galactosidase activity
INS90_RS02105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS90_RS02105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
INS90_RS02110	COG1461	Dihydroxyacetone kinase
INS90_RS02115	COG2376	Dihydroxyacetone kinase
INS90_RS02125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INS90_RS02130	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INS90_RS02140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INS90_RS02145	COG2409	Drug exporters of the RND superfamily
INS90_RS02150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INS90_RS02155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
INS90_RS02170	COG1131	(ABC) transporter
INS90_RS02185	COG0247	lactate metabolic process
INS90_RS02195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
INS90_RS02200	COG2390	Transcriptional regulator
INS90_RS02205	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
INS90_RS02215	COG1194	a g-specific adenine glycosylase
INS90_RS02225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INS90_RS02230	COG0569	domain protein
INS90_RS02235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INS90_RS02255	COG0406	alpha-ribazole phosphatase activity
INS90_RS02280	COG0395	ABC-type sugar transport system, permease component
INS90_RS02285	COG1177	transmembrane transport
INS90_RS02290	COG1653	transport
INS90_RS02295	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
INS90_RS02300	COG4948	Mandelate Racemase Muconate Lactonizing
INS90_RS02305	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INS90_RS02310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INS90_RS02320	COG2226	methyltransferase
INS90_RS02325	COG0644	oxidoreductase
INS90_RS02335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS90_RS02340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS90_RS02345	COG0649	NAD binding
INS90_RS02355	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
INS90_RS02360	COG1034	ATP synthesis coupled electron transport
INS90_RS02365	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
INS90_RS02370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
INS90_RS02380	COG0713	ATP synthesis coupled electron transport
INS90_RS02385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INS90_RS02395	COG1007	ATP synthesis coupled electron transport
INS90_RS02400	COG0142	geranyltranstransferase activity
INS90_RS02405	COG0653	protein targeting
INS90_RS02445	COG0419	ATPase involved in DNA repair
INS90_RS02450	COG0420	3'-5' exonuclease activity
INS90_RS02455	COG0483	inositol monophosphate 1-phosphatase activity
INS90_RS02465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INS90_RS02490	COG0747	negative chemotaxis
INS90_RS02495	COG0601	transmembrane transport
INS90_RS02500	COG0444	Belongs to the ABC transporter superfamily
INS90_RS02505	COG4608	Belongs to the ABC transporter superfamily
INS90_RS02510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INS90_RS02515	COG1846	Transcriptional regulator
INS90_RS02515	COG1940	carbohydrate kinase activity
INS90_RS02520	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
INS90_RS02525	COG0363	glucosamine-6-phosphate deaminase activity
INS90_RS02530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
INS90_RS02535	COG1595	DNA-templated transcription, initiation
INS90_RS02550	COG0791	NLP P60 protein
INS90_RS02550	COG3103	Sh3 type 3 domain protein
INS90_RS02550	COG1388	LysM domain
INS90_RS02560	COG0508	dehydrogenase complex catalyzes the overall conversion of
INS90_RS02560	COG0567	Dehydrogenase, E1 component
INS90_RS02565	COG1253	flavin adenine dinucleotide binding
INS90_RS02575	COG4942	peptidase
INS90_RS02575	COG1388	LysM domain
INS90_RS02615	COG0018	arginyl-trna synthetase
INS90_RS02620	COG0019	diaminopimelate decarboxylase activity
INS90_RS02625	COG0460	homoserine dehydrogenase
INS90_RS02630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INS90_RS02635	COG0083	homoserine kinase activity
INS90_RS02650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INS90_RS02655	COG2890	protein-(glutamine-N5) methyltransferase activity
INS90_RS02675	COG0356	it plays a direct role in the translocation of protons across the membrane
INS90_RS02680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INS90_RS02685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INS90_RS02690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INS90_RS02695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INS90_RS02700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INS90_RS02705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INS90_RS02720	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
INS90_RS02755	COG0366	Alpha amylase catalytic
INS90_RS02770	COG1175	transmembrane transport
INS90_RS02775	COG3833	ABC-type maltose transport systems, permease component
INS90_RS02790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INS90_RS02805	COG0366	Alpha amylase catalytic
INS90_RS02815	COG1136	(ABC) transporter
INS90_RS02815	COG0577	efflux transmembrane transporter activity
INS90_RS02830	COG0058	SHG alpha-glucan phosphorylase activity
INS90_RS02835	COG0180	Tryptophanyl-tRNA synthetase
INS90_RS02865	COG3480	Lon protease (S16) C-terminal proteolytic domain
INS90_RS02875	COG1615	UPF0182 protein
INS90_RS02880	COG0366	Alpha amylase catalytic
INS90_RS02880	COG1470	cell adhesion involved in biofilm formation
INS90_RS02890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INS90_RS02895	COG1131	(ABC) transporter
INS90_RS02905	COG0387	Pfam Sodium calcium exchanger
INS90_RS02915	COG1053	succinate dehydrogenase
INS90_RS02935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
INS90_RS02940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INS90_RS02955	COG4989	oxidoreductase activity
INS90_RS02970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
INS90_RS02980	COG4585	Histidine kinase
INS90_RS02985	COG2135	peptidase activity
INS90_RS02990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INS90_RS02995	COG1404	Belongs to the peptidase S8 family
INS90_RS03005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
INS90_RS03010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INS90_RS03015	COG0154	amidase activity
INS90_RS03020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INS90_RS03085	COG0129	dihydroxy-acid dehydratase activity
INS90_RS03090	COG0569	domain protein
INS90_RS03090	COG2985	domain, Protein
INS90_RS03100	COG0440	acetolactate synthase activity
INS90_RS03105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INS90_RS03125	COG0473	3-isopropylmalate dehydrogenase activity
INS90_RS03130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INS90_RS03135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INS90_RS03140	COG1882	Formate acetyltransferase
INS90_RS03145	COG1882	Formate acetyltransferase
INS90_RS03155	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INS90_RS03175	COG4750	Nucleotidyl transferase
INS90_RS03180	COG3475	LICD family
INS90_RS03185	COG1216	Glycosyl transferase, family 2
INS90_RS03185	COG1442	glycosyl transferase family 8
INS90_RS03240	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
INS90_RS03250	COG1162	GTPase activity
INS90_RS03280	COG2190	(PTS) system
INS90_RS03280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INS90_RS03280	COG1263	PTS System
INS90_RS03285	COG2818	Glycosylase
INS90_RS03295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
INS90_RS03300	COG2354	Protein conserved in bacteria
INS90_RS03305	COG3590	peptidase
INS90_RS03315	COG1045	serine acetyltransferase
INS90_RS03325	COG1739	Uncharacterized protein family UPF0029
INS90_RS03360	COG0393	Putative heavy-metal-binding
INS90_RS03395	COG0667	Aldo Keto reductase
INS90_RS03400	COG0544	peptidyl-prolyl cis-trans isomerase activity
INS90_RS03405	COG0740	serine-type endopeptidase activity
INS90_RS03410	COG0740	serine-type endopeptidase activity
INS90_RS03415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INS90_RS03420	COG1605	Chorismate mutase
INS90_RS03420	COG0287	Prephenate dehydrogenase
INS90_RS03440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INS90_RS03460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INS90_RS03465	COG0285	dihydrofolate synthase activity
INS90_RS03475	COG0105	UTP biosynthetic process
INS90_RS03490	COG3069	C4-dicarboxylate transmembrane transporter activity
INS90_RS03520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
INS90_RS03530	COG1837	Belongs to the UPF0109 family
INS90_RS03535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INS90_RS03545	COG0335	large ribosomal subunit rRNA binding
INS90_RS03550	COG0681	Belongs to the peptidase S26 family
INS90_RS03565	COG0792	nuclease activity
INS90_RS03580	COG4974	Belongs to the 'phage' integrase family
INS90_RS03590	COG2860	membrane
INS90_RS03595	COG0052	Belongs to the universal ribosomal protein uS2 family
INS90_RS03600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INS90_RS03615	COG0644	oxidoreductase
INS90_RS03635	COG0528	UMP kinase activity
INS90_RS03640	COG0233	cytoplasmic translational termination
INS90_RS03650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INS90_RS03660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INS90_RS03665	COG0750	zinc metalloprotease
INS90_RS03670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INS90_RS03680	COG0442	prolyl-tRNA aminoacylation
INS90_RS03690	COG0779	Required for maturation of 30S ribosomal subunits
INS90_RS03705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INS90_RS03710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INS90_RS03715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INS90_RS03720	COG5002	protein histidine kinase activity
INS90_RS03730	COG2271	Major facilitator Superfamily
INS90_RS03740	COG3842	ATPase activity
INS90_RS03770	COG1131	(ABC) transporter
INS90_RS03785	COG1185	polyribonucleotide nucleotidyltransferase activity
INS90_RS03795	COG0612	Peptidase, M16
INS90_RS03800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INS90_RS03805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INS90_RS03825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INS90_RS03830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
INS90_RS03835	COG1674	ftsk spoiiie
INS90_RS03850	COG1546	Belongs to the CinA family
INS90_RS03850	COG1058	Belongs to the CinA family
INS90_RS03855	COG1396	sequence-specific DNA binding
INS90_RS03865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
INS90_RS03870	COG2137	regulation of response to DNA damage stimulus
INS90_RS03875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INS90_RS03880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INS90_RS03885	COG2813	Specifically methylates the guanine in position
INS90_RS03890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INS90_RS03910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
INS90_RS03915	COG0318	PFAM AMP-dependent synthetase and ligase
INS90_RS03920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INS90_RS03945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
INS90_RS03955	COG2001	Belongs to the MraZ family
INS90_RS03960	COG0275	rRNA processing
INS90_RS03970	COG0768	penicillin binding
INS90_RS03975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INS90_RS03980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INS90_RS03985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INS90_RS03990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INS90_RS04000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INS90_RS04005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INS90_RS04015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INS90_RS04020	COG1496	oxidoreductase activity
INS90_RS04025	COG1799	cell septum assembly
INS90_RS04040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INS90_RS04055	COG0587	DNA-directed DNA polymerase activity
INS90_RS04060	COG2501	S4 domain
INS90_RS04075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS90_RS04080	COG1121	(ABC) transporter
INS90_RS04090	COG0423	glycine-tRNA ligase activity
INS90_RS04100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INS90_RS04115	COG0358	DNA primase activity
INS90_RS04125	COG0805	protein transport
INS90_RS04130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INS90_RS04195	COG1090	epimerase
INS90_RS04215	COG0009	L-threonylcarbamoyladenylate synthase
INS90_RS04235	COG0477	Major facilitator Superfamily
INS90_RS04240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
INS90_RS04275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INS90_RS04280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
INS90_RS04285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INS90_RS04305	COG1940	carbohydrate kinase activity
INS90_RS04320	COG0174	glutamine synthetase
INS90_RS04325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
INS90_RS04345	COG0174	glutamine synthetase
INS90_RS04365	COG0508	dehydrogenase complex catalyzes the overall conversion of
INS90_RS04370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INS90_RS04380	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
INS90_RS04395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS90_RS04410	COG0545	Peptidyl-prolyl cis-trans isomerase
INS90_RS04425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INS90_RS04445	COG0205	6-phosphofructokinase activity
INS90_RS04450	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
INS90_RS04455	COG2815	serine threonine protein kinase
INS90_RS04455	COG0515	serine threonine protein kinase
INS90_RS04470	COG0142	geranyltranstransferase activity
INS90_RS04485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INS90_RS04500	COG0187	DNA topoisomerase II activity
INS90_RS04515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INS90_RS04560	COG0569	domain protein
INS90_RS04575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
INS90_RS04580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INS90_RS04585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
INS90_RS04645	COG2197	response regulator
INS90_RS04650	COG1760	l-serine dehydratase
INS90_RS04655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INS90_RS04660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INS90_RS04670	COG0438	transferase activity, transferring glycosyl groups
INS90_RS04690	COG0217	transcriptional regulatory protein
INS90_RS04695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INS90_RS04700	COG0632	four-way junction helicase activity
INS90_RS04705	COG2255	four-way junction helicase activity
INS90_RS04715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INS90_RS04720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INS90_RS04725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INS90_RS04730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INS90_RS04740	COG1196	nuclear chromosome segregation
INS90_RS04750	COG0124	histidyl-tRNA synthetase
INS90_RS04755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INS90_RS04760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INS90_RS04780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INS90_RS04795	COG2409	Drug exporters of the RND superfamily
INS90_RS04805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INS90_RS04815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INS90_RS04820	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INS90_RS04840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
INS90_RS04855	COG2217	Heavy metal translocating P-type atpase
INS90_RS04860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INS90_RS04865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INS90_RS04870	COG0505	Belongs to the CarA family
INS90_RS04875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
INS90_RS04885	COG0194	GDP metabolic process
INS90_RS04890	COG1758	RNA polymerase activity
INS90_RS04900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INS90_RS04910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INS90_RS04920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INS90_RS04925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
INS90_RS04930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
INS90_RS04935	COG0140	phosphoribosyl-ATP diphosphatase activity
INS90_RS04940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INS90_RS04980	COG1216	Glycosyl transferase, family 2
INS90_RS05005	COG1716	ATPase activity
INS90_RS05015	COG1834	amidinotransferase
INS90_RS05035	COG2801	Transposase and inactivated derivatives
INS90_RS05040	COG0205	6-phosphofructokinase activity
INS90_RS05045	COG1160	GTP binding
INS90_RS05050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INS90_RS05060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
INS90_RS05085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INS90_RS05100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
INS90_RS05105	COG0149	triose-phosphate isomerase activity
INS90_RS05110	COG0126	phosphoglycerate kinase activity
INS90_RS05115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
INS90_RS05120	COG1481	regulation of sporulation
INS90_RS05135	COG0322	excinuclease ABC activity
INS90_RS05160	COG0556	nucleotide-excision repair
INS90_RS05165	COG0237	dephospho-CoA kinase activity
INS90_RS05175	COG0539	negative regulation of cytoplasmic translation
INS90_RS05180	COG2226	methyltransferase
INS90_RS05205	COG0469	pyruvate kinase activity
INS90_RS05210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INS90_RS05215	COG0159	tryptophan synthase activity
INS90_RS05220	COG0133	tryptophan synthase activity
INS90_RS05225	COG0134	indole-3-glycerol-phosphate synthase activity
INS90_RS05235	COG0107	imidazoleglycerol-phosphate synthase activity
INS90_RS05250	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
INS90_RS05260	COG4122	O-methyltransferase activity
INS90_RS05265	COG1222	aaa ATPase
INS90_RS05280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INS90_RS05285	COG1968	undecaprenyl-diphosphatase activity
INS90_RS05300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS90_RS05305	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
INS90_RS05310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INS90_RS05310	COG0519	Catalyzes the synthesis of GMP from XMP
INS90_RS05315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INS90_RS05335	COG0587	DNA-directed DNA polymerase activity
INS90_RS05350	COG1881	PFAM PEBP family protein
INS90_RS05355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
INS90_RS05370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS90_RS05385	COG1119	ATPase activity
INS90_RS05390	COG0297	glycogen (starch) synthase activity
INS90_RS05400	COG0560	Phosphoserine phosphatase
INS90_RS05400	COG3830	Belongs to the UPF0237 family
INS90_RS05415	COG0488	(ABC) transporter
INS90_RS05425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INS90_RS05430	COG2151	metal-sulfur cluster biosynthetic enzyme
INS90_RS05455	COG0719	Fe-S assembly protein
INS90_RS05500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INS90_RS05515	COG0647	UMP catabolic process
INS90_RS05545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS90_RS05550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS90_RS05555	COG1121	(ABC) transporter
INS90_RS05560	COG0803	Belongs to the bacterial solute-binding protein 9 family
INS90_RS05565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INS90_RS05580	COG1476	TRANSCRIPTIONal
INS90_RS05590	COG0165	Argininosuccinate lyase
INS90_RS05595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INS90_RS05600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INS90_RS05610	COG0137	argininosuccinate synthase activity
INS90_RS05620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INS90_RS05625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INS90_RS05630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
INS90_RS05635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INS90_RS05645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INS90_RS05650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INS90_RS05670	COG1902	pentaerythritol trinitrate reductase activity
INS90_RS05675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS90_RS05690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INS90_RS05695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INS90_RS05705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INS90_RS05710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INS90_RS05720	COG0131	Imidazoleglycerol-phosphate dehydratase
INS90_RS05730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INS90_RS05735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INS90_RS05740	COG1381	Involved in DNA repair and RecF pathway recombination
INS90_RS05745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INS90_RS05760	COG0631	protein serine/threonine phosphatase activity
INS90_RS05780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INS90_RS05795	COG0484	heat shock protein binding
INS90_RS05800	COG1420	regulation of RNA biosynthetic process
INS90_RS05820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INS90_RS05825	COG0481	GTPase activity
INS90_RS05845	COG3237	CsbD-like
INS90_RS05850	COG0268	Binds directly to 16S ribosomal RNA
INS90_RS05855	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
INS90_RS05860	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
INS90_RS05875	COG1555	photosystem II stabilization
INS90_RS05875	COG1596	polysaccharide export
INS90_RS05880	COG0433	COG0433 Predicted ATPase
INS90_RS05890	COG0495	leucyl-tRNA aminoacylation
INS90_RS05915	COG0813	purine-nucleoside phosphorylase activity
INS90_RS05920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS90_RS05920	COG1321	iron dependent repressor
INS90_RS05925	COG1435	thymidine kinase activity
INS90_RS05955	COG1121	(ABC) transporter
INS90_RS05960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INS90_RS05980	COG0671	phosphoesterase, PA-phosphatase related
INS90_RS06000	COG1113	amino acid transport
INS90_RS06010	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
INS90_RS06010	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
INS90_RS06015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
INS90_RS06020	COG2011	ABC-type metal ion transport system permease component
INS90_RS06030	COG1113	amino acid transport
INS90_RS06040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
INS90_RS06045	COG0826	peptidase U32
INS90_RS06050	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
INS90_RS06055	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
INS90_RS06060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INS90_RS06080	COG2962	Rard protein
INS90_RS06085	COG1609	Transcriptional regulator
INS90_RS06090	COG3250	beta-galactosidase activity
INS90_RS06115	COG0726	polysaccharide deacetylase
INS90_RS06120	COG0133	tryptophan synthase activity
INS90_RS06145	COG2963	transposase activity
INS90_RS06200	COG4824	toxin secretion phage lysis holin
INS90_RS06280	COG0740	serine-type endopeptidase activity
INS90_RS06285	COG4695	Portal protein
INS90_RS06355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INS90_RS06405	COG3617	BRO family, N-terminal domain
INS90_RS06470	COG3842	ATPase activity
INS90_RS06495	COG0406	alpha-ribazole phosphatase activity
INS90_RS06500	COG0799	negative regulation of ribosome biogenesis
INS90_RS06510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INS90_RS06515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INS90_RS06525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INS90_RS06535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INS90_RS06540	COG1530	ribonuclease E activity
INS90_RS06545	COG1271	oxidase subunit
INS90_RS06550	COG1294	oxidase, subunit
INS90_RS06555	COG4988	ABC transporter
INS90_RS06570	COG1132	(ABC) transporter
INS90_RS06575	COG1132	(ABC) transporter
INS90_RS06600	COG0571	ribonuclease III activity
INS90_RS06615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INS90_RS06625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INS90_RS06630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INS90_RS06640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INS90_RS06645	COG1333	cytochrome c biogenesis protein
INS90_RS06650	COG0785	Cytochrome C biogenesis protein
INS90_RS06670	COG0561	phosphatase activity
INS90_RS06680	COG3976	FMN-binding domain protein
INS90_RS06680	COG1053	succinate dehydrogenase
INS90_RS06680	COG0431	NADPH-dependent FMN reductase
INS90_RS06685	COG1181	Belongs to the D-alanine--D-alanine ligase family
INS90_RS06695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INS90_RS06710	COG0066	3-isopropylmalate dehydratase activity
INS90_RS06715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INS90_RS06725	COG0438	transferase activity, transferring glycosyl groups
INS90_RS06740	COG4975	Glucose uptake
INS90_RS06745	COG0339	signal peptide processing
INS90_RS06780	COG1609	Transcriptional regulator
INS90_RS06805	COG0179	Fumarylacetoacetate (FAA) hydrolase
INS90_RS06810	COG1022	Amp-dependent synthetase and ligase
INS90_RS06835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INS90_RS06840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
INS90_RS06845	COG1234	tRNA 3'-trailer cleavage
INS90_RS06850	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INS90_RS06860	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
INS90_RS06885	COG0569	domain protein
INS90_RS06885	COG2985	domain, Protein
INS90_RS06900	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INS90_RS06905	COG0737	Belongs to the 5'-nucleotidase family
INS90_RS06910	COG0778	Nitroreductase
INS90_RS06985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INS90_RS07030	COG1619	proteins homologs of microcin C7 resistance protein MccF
INS90_RS07040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INS90_RS07045	COG0739	heme binding
INS90_RS07050	COG2177	Part of the ABC transporter FtsEX involved in
INS90_RS07055	COG2884	Cell division ATP-binding protein ftsE
INS90_RS07060	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INS90_RS07135	COG0513	Belongs to the DEAD box helicase family
INS90_RS07140	COG2095	MarC family integral membrane protein
INS90_RS07150	COG0006	proline dipeptidase activity
INS90_RS07155	COG2239	Acts as a magnesium transporter
INS90_RS07180	COG1611	Belongs to the LOG family
INS90_RS07190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INS90_RS07195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INS90_RS07215	COG1079	Belongs to the binding-protein-dependent transport system permease family
INS90_RS07220	COG4603	Belongs to the binding-protein-dependent transport system permease family
INS90_RS07225	COG3845	ABC transporter
INS90_RS07230	COG1744	ABC transporter substrate-binding protein PnrA-like
INS90_RS07250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INS90_RS07255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INS90_RS07265	COG1268	BioY protein
INS90_RS07270	COG0736	holo-[acyl-carrier-protein] synthase activity
INS90_RS07275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INS90_RS07280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INS90_RS07285	COG4770	biotin carboxylase activity
INS90_RS07305	COG0644	oxidoreductase
INS90_RS07310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INS90_RS07325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INS90_RS07330	COG2271	Major facilitator Superfamily
INS90_RS07335	COG2030	dehydratase
INS90_RS07365	COG0110	maltose O-acetyltransferase activity
INS90_RS07375	COG0039	L-malate dehydrogenase activity
INS90_RS07420	COG1484	DNA-dependent DNA replication
INS90_RS07435	COG0166	Belongs to the GPI family
INS90_RS07440	COG0205	6-phosphofructokinase activity
INS90_RS07470	COG0045	succinate-CoA ligase (ADP-forming) activity
INS90_RS07475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INS90_RS07475	COG2755	lipolytic protein G-D-S-L family
INS90_RS07485	COG5646	InterPro IPR014922
INS90_RS07510	COG0280	phosphate acetyltransferase
INS90_RS07510	COG0857	belongs to the CobB CobQ family
INS90_RS07515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INS90_RS07535	COG0726	polysaccharide deacetylase
INS90_RS07545	COG1136	(ABC) transporter
INS90_RS07565	COG0114	fumarate hydratase activity
INS90_RS07590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
INS90_RS07600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INS90_RS07605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INS90_RS07610	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INS90_RS07615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INS90_RS07620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INS90_RS07630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INS90_RS07645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INS90_RS07650	COG0733	neurotransmitter:sodium symporter activity
INS90_RS07660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INS90_RS07665	COG1053	succinate dehydrogenase
INS90_RS07690	COG0802	atpase or kinase
INS90_RS07695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INS90_RS07705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INS90_RS07710	COG1072	(Pantothenic acid kinase))
INS90_RS07720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INS90_RS07725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INS90_RS07735	COG4720	Psort location CytoplasmicMembrane, score
INS90_RS07740	COG1122	ATPase activity
INS90_RS07745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
INS90_RS07760	COG0101	tRNA pseudouridine synthase activity
INS90_RS07765	COG1940	carbohydrate kinase activity
INS90_RS07775	COG0765	amino acid transport
INS90_RS07780	COG1126	abc transporter atp-binding protein
INS90_RS07785	COG0640	Transcriptional regulator
INS90_RS07795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INS90_RS07805	COG0789	Transcriptional regulator
INS90_RS07810	COG0203	ribosomal protein L17
INS90_RS07815	COG0202	RNA polymerase activity
INS90_RS07825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INS90_RS07830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INS90_RS07835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INS90_RS07840	COG0024	Methionine aminopeptidase
INS90_RS07845	COG0563	adenylate kinase activity
INS90_RS07855	COG0200	Binds to the 23S rRNA
INS90_RS07860	COG1841	ribosomal large subunit assembly
INS90_RS07865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INS90_RS07875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INS90_RS07880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INS90_RS07885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INS90_RS07890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INS90_RS07895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INS90_RS07900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INS90_RS07915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INS90_RS07920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INS90_RS07925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INS90_RS07930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INS90_RS07935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INS90_RS07940	COG0089	rRNA binding
INS90_RS07945	COG0088	Forms part of the polypeptide exit tunnel
INS90_RS07950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INS90_RS07955	COG0051	transcription antitermination factor activity, RNA binding
INS90_RS07965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
INS90_RS07970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INS90_RS07975	COG0049	tRNA binding
INS90_RS07980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INS90_RS07985	COG0833	amino acid
INS90_RS07990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INS90_RS07995	COG0085	RNA polymerase activity
INS90_RS08000	COG0222	ribosome binding
INS90_RS08005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INS90_RS08010	COG0572	uridine kinase
INS90_RS08015	COG0081	regulation of translation
INS90_RS08020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INS90_RS08040	COG0436	Aminotransferase
INS90_RS08050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
INS90_RS08065	COG0812	UDP-N-acetylmuramate dehydrogenase activity
INS90_RS08070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INS90_RS08090	COG1666	GTP binding
INS90_RS08100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
INS90_RS08110	COG5401	PFAM Sporulation and spore germination
INS90_RS08115	COG5000	phosphorelay sensor kinase activity
INS90_RS08115	COG5002	protein histidine kinase activity
INS90_RS08120	COG0745	RESPONSE REGULATOR receiver
INS90_RS08140	COG0714	Associated with various cellular activities
INS90_RS08185	COG0483	inositol monophosphate 1-phosphatase activity
INS90_RS08200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
INS90_RS08205	COG0385	Bile acid
INS90_RS08230	COG1216	Glycosyl transferase, family 2
INS90_RS08230	COG0438	transferase activity, transferring glycosyl groups
INS90_RS08250	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INS90_RS08275	COG0438	transferase activity, transferring glycosyl groups
INS90_RS08300	COG0673	inositol 2-dehydrogenase activity
INS90_RS08310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INS90_RS08325	COG1088	dTDP-glucose 4,6-dehydratase activity
INS90_RS08345	COG1316	TRANSCRIPTIONal
INS90_RS08355	COG0642	Histidine kinase
INS90_RS08360	COG0745	RESPONSE REGULATOR receiver
INS90_RS08375	COG0424	maF-like protein
INS90_RS08410	COG1217	gtp-binding protein TYPA
INS90_RS08420	COG1132	(ABC) transporter
INS90_RS08425	COG1132	(ABC) transporter
INS90_RS08450	COG0321	lipoyl(octanoyl) transferase activity
INS90_RS08455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INS90_RS08465	COG1362	aminopeptidase activity
INS90_RS08480	COG2838	Isocitrate dehydrogenase
INS90_RS08485	COG2391	methyltransferase activity
INS90_RS08490	COG0425	Belongs to the sulfur carrier protein TusA family
INS90_RS08510	COG2116	formate transmembrane transporter activity
INS90_RS08520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INS90_RS08530	COG0242	peptide deformylase activity
INS90_RS08535	COG1970	mechanosensitive ion channel activity
INS90_RS08545	COG1174	glycine betaine transport
INS90_RS08550	COG1174	glycine betaine transport
INS90_RS08555	COG0517	IMP dehydrogenase activity
INS90_RS08555	COG1125	glycine betaine transport
INS90_RS08565	COG0778	Nitroreductase
INS90_RS08590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INS90_RS08590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
INS90_RS08675	COG0012	GTP binding
INS90_RS08685	COG1322	Protein conserved in bacteria
INS90_RS08690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INS90_RS08700	COG1570	exodeoxyribonuclease VII activity
INS90_RS08705	COG1722	exodeoxyribonuclease VII activity
INS90_RS08710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INS90_RS08715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INS90_RS08725	COG2326	polyphosphate kinase activity
INS90_RS08730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
INS90_RS08735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INS90_RS08740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INS90_RS08755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INS90_RS08760	COG1012	belongs to the aldehyde dehydrogenase family
INS90_RS08775	COG1131	(ABC) transporter
INS90_RS08780	COG2188	Transcriptional regulator
INS90_RS08805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INS90_RS08825	COG0148	phosphopyruvate hydratase activity
INS90_RS08835	COG0193	aminoacyl-tRNA hydrolase activity
INS90_RS08845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INS90_RS08850	COG1136	(ABC) transporter
INS90_RS08860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INS90_RS08885	COG4152	abc transporter atp-binding protein
INS90_RS08890	COG1668	transmembrane transport
INS90_RS08900	COG0488	(ABC) transporter
INS90_RS08905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
INS90_RS08910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INS90_RS08920	COG0084	hydrolase, TatD family'
INS90_RS08925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INS90_RS08935	COG1335	isochorismatase
INS90_RS08965	COG2873	o-acetylhomoserine
INS90_RS08975	COG1131	(ABC) transporter
INS90_RS08990	COG2813	Specifically methylates the guanine in position
INS90_RS08995	COG0667	Aldo Keto reductase
INS90_RS09000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INS90_RS09015	COG1120	ATPase activity
INS90_RS09020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS90_RS09030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INS90_RS09050	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
INS90_RS09050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INS90_RS09055	COG1620	l-lactate permease
INS90_RS09060	COG0247	lactate metabolic process
INS90_RS09070	COG1556	Lactate utilization protein
INS90_RS09090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
INS90_RS09100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INS90_RS09100	COG1263	PTS System
INS90_RS09115	COG1131	(ABC) transporter
INS90_RS09120	COG1051	belongs to the nudix hydrolase family
INS90_RS09130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INS90_RS09155	COG1511	domain protein
INS90_RS09165	COG2848	UPF0210 protein
INS90_RS09170	COG3830	Belongs to the UPF0237 family
INS90_RS09175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INS90_RS09180	COG0254	rRNA binding
INS90_RS09185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INS90_RS09190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INS90_RS09195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INS90_RS09215	COG1120	ATPase activity
INS90_RS09220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS90_RS09225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INS90_RS09230	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
INS90_RS09240	COG2801	Transposase and inactivated derivatives
INS90_RS09360	COG0589	response to stress
INS90_RS09380	COG2252	PERMEase
INS90_RS09385	COG1482	cell wall glycoprotein biosynthetic process
INS90_RS09395	COG1278	Cold shock
INS90_RS09405	COG1842	Phage shock protein A
INS90_RS09415	COG0745	RESPONSE REGULATOR receiver
INS90_RS09420	COG2205	protein histidine kinase activity
INS90_RS09430	COG4221	oxidoreductase activity
INS90_RS09440	COG0459	protein refolding
INS90_RS09455	COG1136	(ABC) transporter
INS90_RS09455	COG0577	efflux transmembrane transporter activity
INS90_RS09465	COG1136	(ABC) transporter
INS90_RS09470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INS90_RS09480	COG0395	ABC-type sugar transport system, permease component
INS90_RS09485	COG1175	transmembrane transport
INS90_RS09505	COG1609	Transcriptional regulator
INS90_RS09535	COG3842	ATPase activity
INS90_RS09550	COG1653	transport
INS90_RS09555	COG1175	transmembrane transport
INS90_RS09580	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INS90_RS09885	COG2233	PERMEase
INS90_RS09900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INS90_RS09905	COG0215	cysteine-tRNA ligase activity
INS90_RS09915	COG1136	(ABC) transporter
INS90_RS09930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
INS90_RS09935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INS90_RS09945	COG0745	RESPONSE REGULATOR receiver
INS90_RS09955	COG0704	Plays a role in the regulation of phosphate uptake
INS90_RS09970	COG2801	Transposase and inactivated derivatives
INS90_RS09990	COG0588	phosphoglycerate mutase activity
INS90_RS10205	COG0629	single-stranded DNA binding
INS90_RS10280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INS90_RS10285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
INS90_RS10290	COG1754	DNA topoisomerase type I activity
INS90_RS10290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INS90_RS10305	COG3655	Transcriptional regulator
INS90_RS10310	COG1205	dead DEAH box helicase
INS90_RS10310	COG1111	helicase
INS90_RS10355	COG2267	carboxylic ester hydrolase activity
INS90_RS10385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INS90_RS10405	COG3304	Inner membrane component domain
INS90_RS10415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
INS90_RS10425	COG0315	cyclic pyranopterin monophosphate synthase activity
INS90_RS10435	COG0521	Mo-molybdopterin cofactor biosynthetic process
INS90_RS10480	COG0471	metal ion transport
INS90_RS10485	COG3852	Histidine kinase
INS90_RS10510	COG2801	Transposase and inactivated derivatives
INS90_RS10565	COG4868	Belongs to the UPF0371 family
INS90_RS10570	COG1114	Component of the transport system for branched-chain amino acids
INS90_RS10585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INS90_RS10600	COG1215	transferase activity, transferring glycosyl groups
INS90_RS10610	COG0077	Prephenate dehydratase
INS90_RS10620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INS90_RS10625	COG0561	phosphatase activity
INS90_RS10650	COG0471	metal ion transport
INS90_RS10690	COG1518	maintenance of DNA repeat elements
INS90_RS10755	COG1643	Atp-dependent helicase
INS90_RS10765	COG0569	domain protein
INS90_RS10770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INS90_RS10790	COG0343	queuine tRNA-ribosyltransferase activity
INS90_RS10800	COG1428	Deoxynucleoside kinase
INS90_RS10845	COG0351	phosphomethylpyrimidine kinase
INS90_RS10860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INS90_RS10865	COG0084	hydrolase, TatD family'
INS90_RS10875	COG0305	Participates in initiation and elongation during chromosome replication
INS90_RS10895	COG0359	binds to the 23S rRNA
INS90_RS10900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INS90_RS10910	COG0360	Binds together with S18 to 16S ribosomal RNA
INS90_RS10915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INS90_RS10920	COG0628	permease
INS90_RS10950	COG0492	ferredoxin-NADP+ reductase activity
INS90_RS10955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INS90_RS10960	COG1181	Belongs to the D-alanine--D-alanine ligase family
INS90_RS10975	COG0357	Ribosomal RNA small subunit methyltransferase G
INS90_RS10985	COG0706	membrane insertase activity
INS90_RS10990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INS90_RS10995	COG0594	ribonuclease P activity
INS90_RS11000	COG0230	Belongs to the bacterial ribosomal protein bL34 family