locus-tag	class	description
TPAU_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TPAU_RS00020	COG0592	DNA-directed DNA polymerase activity
TPAU_RS00025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TPAU_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TPAU_RS00040	COG0477	Major facilitator Superfamily
TPAU_RS00045	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TPAU_RS00050	COG0187	DNA topoisomerase II activity
TPAU_RS00055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TPAU_RS00090	COG1253	flavin adenine dinucleotide binding
TPAU_RS00095	COG1253	flavin adenine dinucleotide binding
TPAU_RS00145	COG2815	serine threonine protein kinase
TPAU_RS00145	COG0515	serine threonine protein kinase
TPAU_RS00150	COG0515	serine threonine protein kinase
TPAU_RS00155	COG0768	penicillin binding
TPAU_RS00170	COG1716	ATPase activity
TPAU_RS00175	COG1716	ATPase activity
TPAU_RS00195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TPAU_RS00200	COG2814	Major facilitator Superfamily
TPAU_RS00220	COG1063	alcohol dehydrogenase
TPAU_RS00240	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS00250	COG1073	alpha beta
TPAU_RS00275	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TPAU_RS00285	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TPAU_RS00310	COG0297	glycogen (starch) synthase activity
TPAU_RS00350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPAU_RS00365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TPAU_RS00385	COG3336	cytochrome c oxidase
TPAU_RS00425	COG0657	acetylesterase activity
TPAU_RS00450	COG0778	Nitroreductase
TPAU_RS00455	COG1376	ErfK ybiS ycfS ynhG family protein
TPAU_RS00480	COG0745	RESPONSE REGULATOR receiver
TPAU_RS00485	COG2205	protein histidine kinase activity
TPAU_RS00500	COG0745	RESPONSE REGULATOR receiver
TPAU_RS00505	COG5002	protein histidine kinase activity
TPAU_RS00515	COG3559	Exporter of polyketide antibiotics
TPAU_RS00520	COG1131	(ABC) transporter
TPAU_RS00540	COG1252	NADH dehydrogenase
TPAU_RS00550	COG0067	glutamate synthase
TPAU_RS00550	COG0069	glutamate synthase activity
TPAU_RS00550	COG0070	glutamate synthase
TPAU_RS00575	COG2501	S4 domain
TPAU_RS00590	COG1012	belongs to the aldehyde dehydrogenase family
TPAU_RS00640	COG2119	membrane
TPAU_RS00690	COG1316	TRANSCRIPTIONal
TPAU_RS00700	COG2252	PERMEase
TPAU_RS00710	COG3226	Transcriptional regulator
TPAU_RS00800	COG0561	phosphatase activity
TPAU_RS00820	COG1216	Glycosyl transferase, family 2
TPAU_RS00830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TPAU_RS00835	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TPAU_RS00845	COG5001	Diguanylate cyclase
TPAU_RS00860	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
TPAU_RS00865	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
TPAU_RS00870	COG2957	Belongs to the agmatine deiminase family
TPAU_RS00875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS00880	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS00885	COG3321	synthase
TPAU_RS00885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPAU_RS00885	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
TPAU_RS00890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TPAU_RS00895	COG0277	FAD linked oxidase domain protein
TPAU_RS00900	COG1956	GAF domain-containing protein
TPAU_RS00925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPAU_RS00930	COG1349	DNA-binding transcription factor activity
TPAU_RS00940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPAU_RS00940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPAU_RS00940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPAU_RS00955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TPAU_RS00965	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TPAU_RS00970	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TPAU_RS00985	COG0583	DNA-binding transcription factor activity
TPAU_RS01000	COG3191	aminopeptidase activity
TPAU_RS01010	COG1846	Transcriptional regulator
TPAU_RS01050	COG0583	DNA-binding transcription factor activity
TPAU_RS01065	COG1396	sequence-specific DNA binding
TPAU_RS01070	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TPAU_RS01075	COG1760	l-serine dehydratase
TPAU_RS01080	COG0494	nUDIX hydrolase
TPAU_RS01085	COG3214	Protein conserved in bacteria
TPAU_RS01090	COG2184	nucleotidyltransferase activity
TPAU_RS01095	COG0488	(ABC) transporter
TPAU_RS01130	COG3012	SEC-C Motif Domain Protein
TPAU_RS01150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TPAU_RS01190	COG2161	toxin-antitoxin pair type II binding
TPAU_RS01195	COG2026	Addiction module toxin, RelE StbE family
TPAU_RS01260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TPAU_RS01335	COG2801	Transposase and inactivated derivatives
TPAU_RS01355	COG2801	Transposase and inactivated derivatives
TPAU_RS01365	COG3547	Transposase (IS116 IS110 IS902 family)
TPAU_RS01390	COG2801	Transposase and inactivated derivatives
TPAU_RS01395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS01415	COG0028	Belongs to the TPP enzyme family
TPAU_RS01490	COG2801	Transposase and inactivated derivatives
TPAU_RS01555	COG3328	transposase activity
TPAU_RS01565	COG1674	ftsk spoiiie
TPAU_RS01605	COG1404	Belongs to the peptidase S8 family
TPAU_RS01640	COG1309	transcriptional regulator
TPAU_RS01645	COG0183	Belongs to the thiolase family
TPAU_RS01695	COG3706	GGDEF domain
TPAU_RS01710	COG2197	response regulator
TPAU_RS01715	COG2217	Heavy metal translocating P-type atpase
TPAU_RS01730	COG4290	ribonuclease
TPAU_RS01735	COG1309	transcriptional regulator
TPAU_RS01760	COG2409	Drug exporters of the RND superfamily
TPAU_RS01770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TPAU_RS01800	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TPAU_RS01805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TPAU_RS01810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TPAU_RS01810	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TPAU_RS01840	COG1473	amidohydrolase
TPAU_RS01850	COG0583	DNA-binding transcription factor activity
TPAU_RS01870	COG0531	amino acid
TPAU_RS01875	COG1012	belongs to the aldehyde dehydrogenase family
TPAU_RS01925	COG1136	(ABC) transporter
TPAU_RS01925	COG0577	efflux transmembrane transporter activity
TPAU_RS02035	COG4981	capsule polysaccharide biosynthetic process
TPAU_RS02060	COG1472	Belongs to the glycosyl hydrolase 3 family
TPAU_RS02065	COG1309	transcriptional regulator
TPAU_RS02070	COG2030	dehydratase
TPAU_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS02080	COG0183	Belongs to the thiolase family
TPAU_RS02085	COG1832	CoA-binding protein
TPAU_RS02110	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS02130	COG0477	Major facilitator Superfamily
TPAU_RS02165	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS02175	COG2066	Belongs to the glutaminase family
TPAU_RS02175	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
TPAU_RS02180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TPAU_RS02195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TPAU_RS02280	COG2181	nitrate reductase activity
TPAU_RS02280	COG0247	lactate metabolic process
TPAU_RS02305	COG0708	Exodeoxyribonuclease III
TPAU_RS02370	COG4106	trans-aconitate 2-methyltransferase activity
TPAU_RS02375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TPAU_RS02390	COG0443	Heat shock 70 kDa protein
TPAU_RS02395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TPAU_RS02400	COG0484	heat shock protein binding
TPAU_RS02405	COG0789	Transcriptional regulator
TPAU_RS02430	COG0542	response to heat
TPAU_RS02435	COG2267	carboxylic ester hydrolase activity
TPAU_RS02450	COG0371	Dehydrogenase
TPAU_RS02460	COG2149	membrane
TPAU_RS02480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TPAU_RS02495	COG0488	(ABC) transporter
TPAU_RS02500	COG0586	Pfam SNARE associated Golgi protein
TPAU_RS02505	COG0586	Pfam SNARE associated Golgi protein
TPAU_RS02535	COG4129	membrane
TPAU_RS02545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TPAU_RS02560	COG0745	RESPONSE REGULATOR receiver
TPAU_RS02565	COG2205	protein histidine kinase activity
TPAU_RS02570	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TPAU_RS02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
TPAU_RS02590	COG2814	Major facilitator Superfamily
TPAU_RS02595	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TPAU_RS02675	COG1690	Belongs to the RtcB family
TPAU_RS02700	COG0442	prolyl-tRNA aminoacylation
TPAU_RS02710	COG0477	Major facilitator Superfamily
TPAU_RS02725	COG2027	D-alanyl-D-alanine carboxypeptidase
TPAU_RS02735	COG0037	tRNA processing
TPAU_RS02740	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TPAU_RS02755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPAU_RS02760	COG0302	gtp cyclohydrolase
TPAU_RS02765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TPAU_RS02795	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TPAU_RS02800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TPAU_RS02805	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TPAU_RS02815	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TPAU_RS02835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TPAU_RS02850	COG1902	pentaerythritol trinitrate reductase activity
TPAU_RS02850	COG0446	pyridine nucleotide-disulphide oxidoreductase
TPAU_RS02860	COG4221	oxidoreductase activity
TPAU_RS02865	COG2072	flavoprotein involved in K transport
TPAU_RS02885	COG0596	Alpha beta hydrolase
TPAU_RS02890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TPAU_RS02895	COG4221	oxidoreductase activity
TPAU_RS02900	COG1309	transcriptional regulator
TPAU_RS02910	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS02925	COG0288	reversible hydration of carbon dioxide
TPAU_RS02935	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TPAU_RS02940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TPAU_RS02955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TPAU_RS02970	COG0215	cysteine-tRNA ligase activity
TPAU_RS02975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TPAU_RS02985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TPAU_RS02995	COG1121	(ABC) transporter
TPAU_RS03020	COG3485	protocatechuate 3,4-dioxygenase
TPAU_RS03025	COG3485	protocatechuate 3,4-dioxygenase
TPAU_RS03030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TPAU_RS03035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TPAU_RS03050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TPAU_RS03055	COG1414	Transcriptional regulator
TPAU_RS03060	COG2814	Major facilitator Superfamily
TPAU_RS03080	COG0438	transferase activity, transferring glycosyl groups
TPAU_RS03090	COG0477	Major facilitator Superfamily
TPAU_RS03115	COG0477	Major facilitator Superfamily
TPAU_RS03120	COG0667	Aldo Keto reductase
TPAU_RS03130	COG2318	DinB family
TPAU_RS03140	COG1119	ATPase activity
TPAU_RS03145	COG4106	trans-aconitate 2-methyltransferase activity
TPAU_RS03150	COG0583	DNA-binding transcription factor activity
TPAU_RS03155	COG2814	Major facilitator Superfamily
TPAU_RS03160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS03175	COG0577	efflux transmembrane transporter activity
TPAU_RS03175	COG1136	(ABC) transporter
TPAU_RS03180	COG2197	response regulator
TPAU_RS03190	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
TPAU_RS03200	COG0588	phosphoglycerate mutase activity
TPAU_RS03210	COG5002	protein histidine kinase activity
TPAU_RS03245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TPAU_RS03275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TPAU_RS03280	COG0181	hydroxymethylbilane synthase activity
TPAU_RS03310	COG2608	mercury ion transmembrane transporter activity
TPAU_RS03315	COG2954	triphosphatase activity
TPAU_RS03320	COG2409	Drug exporters of the RND superfamily
TPAU_RS03340	COG0154	amidase activity
TPAU_RS03345	COG2957	Belongs to the agmatine deiminase family
TPAU_RS03360	COG2272	Belongs to the type-B carboxylesterase lipase family
TPAU_RS03365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TPAU_RS03375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TPAU_RS03380	COG0406	alpha-ribazole phosphatase activity
TPAU_RS03390	COG0785	Cytochrome C biogenesis protein
TPAU_RS03400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TPAU_RS03415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TPAU_RS03425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TPAU_RS03450	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS03485	COG3629	intracellular signal transduction
TPAU_RS03535	COG1250	3-hydroxyacyl-CoA dehydrogenase
TPAU_RS03540	COG4948	Mandelate Racemase Muconate Lactonizing
TPAU_RS03555	COG2409	Drug exporters of the RND superfamily
TPAU_RS03560	COG1937	Protein conserved in bacteria
TPAU_RS03565	COG3268	Saccharopine dehydrogenase
TPAU_RS03580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TPAU_RS03590	COG0438	transferase activity, transferring glycosyl groups
TPAU_RS03595	COG2226	methyltransferase
TPAU_RS03600	COG0142	geranyltranstransferase activity
TPAU_RS03605	COG0501	Belongs to the peptidase M48B family
TPAU_RS03615	COG1666	GTP binding
TPAU_RS03640	COG2030	dehydratase
TPAU_RS03645	COG2030	dehydratase
TPAU_RS03655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TPAU_RS03665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TPAU_RS03670	COG0081	regulation of translation
TPAU_RS03720	COG0085	RNA polymerase activity
TPAU_RS03755	COG4948	Mandelate Racemase Muconate Lactonizing
TPAU_RS03760	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS03770	COG2186	Transcriptional regulator
TPAU_RS03805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TPAU_RS03820	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS03830	COG0183	Belongs to the thiolase family
TPAU_RS03845	COG1073	alpha beta
TPAU_RS03850	COG2376	Dihydroxyacetone kinase
TPAU_RS03875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPAU_RS03895	COG0640	Transcriptional regulator
TPAU_RS03905	COG0765	amino acid transport
TPAU_RS03910	COG1126	abc transporter atp-binding protein
TPAU_RS03925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TPAU_RS03930	COG1263	PTS System
TPAU_RS03935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TPAU_RS03940	COG2190	(PTS) system
TPAU_RS03940	COG1263	PTS System
TPAU_RS03940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TPAU_RS03960	COG2188	Transcriptional regulator
TPAU_RS04000	COG1061	Type III restriction enzyme res subunit
TPAU_RS04025	COG4941	Belongs to the sigma-70 factor family
TPAU_RS04040	COG0315	cyclic pyranopterin monophosphate synthase activity
TPAU_RS04045	COG0521	Mo-molybdopterin cofactor biosynthetic process
TPAU_RS04045	COG0315	cyclic pyranopterin monophosphate synthase activity
TPAU_RS04055	COG1819	glycosyl
TPAU_RS04070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TPAU_RS04080	COG1278	Cold shock
TPAU_RS04095	COG2814	Major facilitator Superfamily
TPAU_RS04150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TPAU_RS04160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TPAU_RS04170	COG1953	Uracil, thiamine, allantoin
TPAU_RS04175	COG2814	Major facilitator Superfamily
TPAU_RS04190	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TPAU_RS04210	COG4221	oxidoreductase activity
TPAU_RS04235	COG0545	Peptidyl-prolyl cis-trans isomerase
TPAU_RS04260	COG0656	L-ascorbic acid biosynthetic process
TPAU_RS04270	COG1404	Belongs to the peptidase S8 family
TPAU_RS04280	COG1674	ftsk spoiiie
TPAU_RS04290	COG3547	Transposase (IS116 IS110 IS902 family)
TPAU_RS04305	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TPAU_RS04315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPAU_RS04320	COG0546	phosphoglycolate phosphatase activity
TPAU_RS04350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TPAU_RS04380	COG2154	pterin-4-alpha-carbinolamine dehydratase
TPAU_RS04385	COG0456	acetyltransferase
TPAU_RS04385	COG1214	PFAM Peptidase M22, glycoprotease
TPAU_RS04395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TPAU_RS04415	COG2207	Transcriptional regulator
TPAU_RS04450	COG3547	Transposase (IS116 IS110 IS902 family)
TPAU_RS04460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TPAU_RS04465	COG0459	protein refolding
TPAU_RS04470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS04505	COG0516	GMP reductase activity
TPAU_RS04520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TPAU_RS04520	COG0519	Catalyzes the synthesis of GMP from XMP
TPAU_RS04525	COG0702	epimerase
TPAU_RS04555	COG2197	response regulator
TPAU_RS04560	COG0515	serine threonine protein kinase
TPAU_RS04560	COG2815	serine threonine protein kinase
TPAU_RS04570	COG0833	amino acid
TPAU_RS04635	COG1742	UPF0060 membrane protein
TPAU_RS04675	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TPAU_RS04685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TPAU_RS04705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TPAU_RS04710	COG2814	Major facilitator Superfamily
TPAU_RS04725	COG0708	Exodeoxyribonuclease III
TPAU_RS04730	COG0180	Tryptophanyl-tRNA synthetase
TPAU_RS04745	COG1686	Belongs to the peptidase S11 family
TPAU_RS04805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TPAU_RS04820	COG2009	succinate dehydrogenase
TPAU_RS04835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPAU_RS04845	COG2197	response regulator
TPAU_RS04860	COG2207	Transcriptional regulator
TPAU_RS04895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPAU_RS04915	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TPAU_RS04915	COG1473	amidohydrolase
TPAU_RS04940	COG1595	DNA-templated transcription, initiation
TPAU_RS04950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TPAU_RS04965	COG1349	DNA-binding transcription factor activity
TPAU_RS04980	COG3250	beta-galactosidase activity
TPAU_RS04985	COG0395	ABC-type sugar transport system, permease component
TPAU_RS04990	COG1175	transmembrane transport
TPAU_RS05000	COG3842	ATPase activity
TPAU_RS05015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TPAU_RS05020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TPAU_RS05035	COG2197	response regulator
TPAU_RS05045	COG0477	Major facilitator Superfamily
TPAU_RS05060	COG1201	RNA secondary structure unwinding
TPAU_RS05065	COG2272	Belongs to the type-B carboxylesterase lipase family
TPAU_RS05075	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS05090	COG0431	NADPH-dependent FMN reductase
TPAU_RS05095	COG1396	sequence-specific DNA binding
TPAU_RS05145	COG4770	biotin carboxylase activity
TPAU_RS05205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TPAU_RS05210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TPAU_RS05210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TPAU_RS05220	COG0745	RESPONSE REGULATOR receiver
TPAU_RS05225	COG2205	protein histidine kinase activity
TPAU_RS05235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TPAU_RS05260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPAU_RS05305	COG1316	TRANSCRIPTIONal
TPAU_RS05310	COG1091	dTDP-4-dehydrorhamnose reductase activity
TPAU_RS05320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPAU_RS05330	COG4122	O-methyltransferase activity
TPAU_RS05335	COG1595	DNA-templated transcription, initiation
TPAU_RS05340	COG5662	AntiSigma factor
TPAU_RS05345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPAU_RS05350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TPAU_RS05380	COG0745	RESPONSE REGULATOR receiver
TPAU_RS05385	COG5002	protein histidine kinase activity
TPAU_RS05390	COG5401	PFAM Sporulation and spore germination
TPAU_RS05400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TPAU_RS05405	COG0653	protein targeting
TPAU_RS05475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TPAU_RS05480	COG1162	GTPase activity
TPAU_RS05485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TPAU_RS05500	COG2135	peptidase activity
TPAU_RS05515	COG1012	belongs to the aldehyde dehydrogenase family
TPAU_RS05525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TPAU_RS05535	COG1595	DNA-templated transcription, initiation
TPAU_RS05555	COG1597	lipid kinase activity
TPAU_RS05565	COG0406	alpha-ribazole phosphatase activity
TPAU_RS05570	COG1192	Involved in chromosome partitioning
TPAU_RS05590	COG0513	Belongs to the DEAD box helicase family
TPAU_RS05600	COG1309	transcriptional regulator
TPAU_RS05605	COG0596	Alpha beta hydrolase
TPAU_RS05605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TPAU_RS05620	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS05650	COG0596	Alpha beta hydrolase
TPAU_RS05660	COG0210	DNA helicase
TPAU_RS05670	COG2826	transposase and inactivated derivatives, IS30 family
TPAU_RS05690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TPAU_RS05695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS05725	COG0747	negative chemotaxis
TPAU_RS05730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TPAU_RS05740	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TPAU_RS05750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TPAU_RS05765	COG3220	belongs to the UPF0276 family
TPAU_RS05795	COG2239	Acts as a magnesium transporter
TPAU_RS05800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TPAU_RS05805	COG1611	Belongs to the LOG family
TPAU_RS05810	COG1611	Belongs to the LOG family
TPAU_RS05815	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS05820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TPAU_RS05825	COG0463	Glycosyl transferase, family 2
TPAU_RS05835	COG0789	Transcriptional regulator
TPAU_RS05865	COG0297	glycogen (starch) synthase activity
TPAU_RS05870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TPAU_RS05880	COG1280	lysine exporter protein (LysE YggA)
TPAU_RS05895	COG0300	oxidoreductase activity
TPAU_RS05910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TPAU_RS05930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPAU_RS05940	COG1482	cell wall glycoprotein biosynthetic process
TPAU_RS05950	COG0531	amino acid
TPAU_RS05955	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TPAU_RS05970	COG2239	Acts as a magnesium transporter
TPAU_RS06030	COG0598	Magnesium transport protein CorA
TPAU_RS06050	COG0567	Dehydrogenase, E1 component
TPAU_RS06050	COG0508	dehydrogenase complex catalyzes the overall conversion of
TPAU_RS06060	COG0824	Thioesterase
TPAU_RS06070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TPAU_RS06095	COG2814	Major facilitator Superfamily
TPAU_RS06105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TPAU_RS06140	COG0018	arginyl-trna synthetase
TPAU_RS06150	COG0460	homoserine dehydrogenase
TPAU_RS06155	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TPAU_RS06160	COG0083	homoserine kinase activity
TPAU_RS06175	COG0254	rRNA binding
TPAU_RS06180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TPAU_RS06185	COG2890	protein-(glutamine-N5) methyltransferase activity
TPAU_RS06225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPAU_RS06230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPAU_RS06235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPAU_RS06245	COG0356	it plays a direct role in the translocation of protons across the membrane
TPAU_RS06250	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TPAU_RS06265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TPAU_RS06270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TPAU_RS06275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TPAU_RS06315	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TPAU_RS06335	COG0183	Belongs to the thiolase family
TPAU_RS06360	COG1175	transmembrane transport
TPAU_RS06365	COG0395	ABC-type sugar transport system, permease component
TPAU_RS06370	COG0657	acetylesterase activity
TPAU_RS06375	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS06395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPAU_RS06400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TPAU_RS06405	COG0366	Alpha amylase catalytic
TPAU_RS06415	COG0583	DNA-binding transcription factor activity
TPAU_RS06435	COG1335	isochorismatase
TPAU_RS06440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TPAU_RS06480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TPAU_RS06485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TPAU_RS06490	COG1316	TRANSCRIPTIONal
TPAU_RS06565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TPAU_RS06590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TPAU_RS06600	COG0439	Biotin carboxylase
TPAU_RS06620	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS06635	COG0583	DNA-binding transcription factor activity
TPAU_RS06645	COG1376	ErfK ybiS ycfS ynhG family protein
TPAU_RS06665	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS06670	COG3402	PFAM membrane-flanked domain
TPAU_RS06675	COG3428	Bacterial PH domain
TPAU_RS06690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TPAU_RS06700	COG1131	(ABC) transporter
TPAU_RS06720	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TPAU_RS06725	COG0433	COG0433 Predicted ATPase
TPAU_RS06730	COG0300	oxidoreductase activity
TPAU_RS06735	COG2259	Doxx family
TPAU_RS06745	COG0446	pyridine nucleotide-disulphide oxidoreductase
TPAU_RS06745	COG1902	pentaerythritol trinitrate reductase activity
TPAU_RS06775	COG2851	Citrate transporter
TPAU_RS06780	COG3290	protein histidine kinase activity
TPAU_RS06785	COG4565	transcriptional regulatory protein
TPAU_RS06815	COG0673	inositol 2-dehydrogenase activity
TPAU_RS06825	COG1172	Belongs to the binding-protein-dependent transport system permease family
TPAU_RS06835	COG0673	inositol 2-dehydrogenase activity
TPAU_RS06840	COG1082	Xylose isomerase domain protein TIM barrel
TPAU_RS06850	COG2188	Transcriptional regulator
TPAU_RS06870	COG3718	enzyme involved in inositol metabolism
TPAU_RS06875	COG3962	Belongs to the TPP enzyme family
TPAU_RS06925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TPAU_RS06925	COG2146	nitrite reductase [NAD(P)H] activity
TPAU_RS06930	COG2146	nitrite reductase [NAD(P)H] activity
TPAU_RS06930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TPAU_RS06935	COG0243	molybdopterin cofactor binding
TPAU_RS06940	COG3321	synthase
TPAU_RS06940	COG0604	alcohol dehydrogenase
TPAU_RS06955	COG2902	Dehydrogenase
TPAU_RS06990	COG5001	Diguanylate cyclase
TPAU_RS07005	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TPAU_RS07010	COG3012	SEC-C Motif Domain Protein
TPAU_RS07025	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TPAU_RS07030	COG0501	Belongs to the peptidase M48B family
TPAU_RS07080	COG2197	response regulator
TPAU_RS07100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPAU_RS07105	COG0531	amino acid
TPAU_RS07115	COG1396	sequence-specific DNA binding
TPAU_RS07120	COG1024	Enoyl-CoA hydratase
TPAU_RS07150	COG4974	Belongs to the 'phage' integrase family
TPAU_RS07160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TPAU_RS07235	COG2259	Doxx family
TPAU_RS07265	COG2224	Isocitrate lyase
TPAU_RS07270	COG3340	Belongs to the peptidase S51 family
TPAU_RS07280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPAU_RS07285	COG1120	ATPase activity
TPAU_RS07295	COG1396	sequence-specific DNA binding
TPAU_RS07300	COG3135	benzoate transporter
TPAU_RS07335	COG0544	peptidyl-prolyl cis-trans isomerase activity
TPAU_RS07340	COG0740	serine-type endopeptidase activity
TPAU_RS07345	COG0740	serine-type endopeptidase activity
TPAU_RS07360	COG0488	(ABC) transporter
TPAU_RS07375	COG0525	valine-tRNA ligase activity
TPAU_RS07380	COG0285	dihydrofolate synthase activity
TPAU_RS07395	COG1530	ribonuclease E activity
TPAU_RS07405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TPAU_RS07410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPAU_RS07425	COG0740	serine-type endopeptidase activity
TPAU_RS07430	COG0740	serine-type endopeptidase activity
TPAU_RS07450	COG2814	Major facilitator Superfamily
TPAU_RS07450	COG0477	Major facilitator Superfamily
TPAU_RS07475	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
TPAU_RS07495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TPAU_RS07500	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPAU_RS07500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPAU_RS07515	COG0174	glutamine synthetase
TPAU_RS07520	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TPAU_RS07535	COG0545	Peptidyl-prolyl cis-trans isomerase
TPAU_RS07575	COG0174	glutamine synthetase
TPAU_RS07590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TPAU_RS07595	COG2814	Major facilitator Superfamily
TPAU_RS07600	COG0321	lipoyl(octanoyl) transferase activity
TPAU_RS07640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TPAU_RS07645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TPAU_RS07655	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TPAU_RS07680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TPAU_RS07695	COG0789	Transcriptional regulator
TPAU_RS07710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TPAU_RS07725	COG2826	transposase and inactivated derivatives, IS30 family
TPAU_RS07740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TPAU_RS07745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPAU_RS07750	COG0066	3-isopropylmalate dehydratase activity
TPAU_RS07755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TPAU_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS07785	COG0477	Major facilitator Superfamily
TPAU_RS07800	COG1917	Cupin 2, conserved barrel domain protein
TPAU_RS07810	COG0456	acetyltransferase
TPAU_RS07820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TPAU_RS07835	COG0477	Major facilitator Superfamily
TPAU_RS07840	COG0742	ribosomal rna small subunit methyltransferase
TPAU_RS07845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TPAU_RS07850	COG3599	regulation of cell shape
TPAU_RS07860	COG0571	ribonuclease III activity
TPAU_RS07880	COG1254	Belongs to the acylphosphatase family
TPAU_RS07890	COG0754	glutathionylspermidine amidase activity
TPAU_RS07895	COG3766	membrane
TPAU_RS07900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TPAU_RS07905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPAU_RS07910	COG0438	transferase activity, transferring glycosyl groups
TPAU_RS07920	COG0438	transferase activity, transferring glycosyl groups
TPAU_RS07925	COG0438	transferase activity, transferring glycosyl groups
TPAU_RS07960	COG1196	nuclear chromosome segregation
TPAU_RS07990	COG3665	Urea carboxylase-associated protein
TPAU_RS07995	COG1984	allophanate hydrolase subunit 2
TPAU_RS08015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS08025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPAU_RS08080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TPAU_RS08110	COG0076	glutamate decarboxylase activity
TPAU_RS08115	COG0228	four-way junction DNA binding
TPAU_RS08125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TPAU_RS08130	COG0336	Belongs to the RNA methyltransferase TrmD family
TPAU_RS08140	COG0745	RESPONSE REGULATOR receiver
TPAU_RS08180	COG0335	large ribosomal subunit rRNA binding
TPAU_RS08190	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TPAU_RS08210	COG3842	ATPase activity
TPAU_RS08215	COG1175	transmembrane transport
TPAU_RS08220	COG0395	ABC-type sugar transport system, permease component
TPAU_RS08235	COG0792	nuclease activity
TPAU_RS08265	COG2801	Transposase and inactivated derivatives
TPAU_RS08270	COG0477	Major facilitator Superfamily
TPAU_RS08285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TPAU_RS08290	COG2011	ABC-type metal ion transport system permease component
TPAU_RS08295	COG4974	Belongs to the 'phage' integrase family
TPAU_RS08315	COG0501	Belongs to the peptidase M48B family
TPAU_RS08320	COG2814	Major facilitator Superfamily
TPAU_RS08325	COG1823	symporter activity
TPAU_RS08340	COG2272	Belongs to the type-B carboxylesterase lipase family
TPAU_RS08350	COG1115	amino acid carrier protein
TPAU_RS08355	COG2801	Transposase and inactivated derivatives
TPAU_RS08365	COG1115	amino acid carrier protein
TPAU_RS08370	COG0052	Belongs to the universal ribosomal protein uS2 family
TPAU_RS08400	COG0233	cytoplasmic translational termination
TPAU_RS08420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TPAU_RS08440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TPAU_RS08445	COG0750	zinc metalloprotease
TPAU_RS08450	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TPAU_RS08480	COG0768	penicillin binding
TPAU_RS08495	COG1492	cobalamin metabolic process
TPAU_RS08500	COG2267	carboxylic ester hydrolase activity
TPAU_RS08515	COG0579	oxidoreductase
TPAU_RS08540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TPAU_RS08540	COG1648	precorrin-2 dehydrogenase activity
TPAU_RS08555	COG3022	response to hydroperoxide
TPAU_RS08560	COG0442	prolyl-tRNA aminoacylation
TPAU_RS08565	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
TPAU_RS08600	COG0481	GTPase activity
TPAU_RS08600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TPAU_RS08610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TPAU_RS08615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TPAU_RS08645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TPAU_RS08655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TPAU_RS08665	COG0372	Belongs to the citrate synthase family
TPAU_RS08680	COG1321	iron dependent repressor
TPAU_RS08695	COG3540	Alkaline phosphatase
TPAU_RS08705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TPAU_RS08705	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TPAU_RS08710	COG1185	polyribonucleotide nucleotidyltransferase activity
TPAU_RS08735	COG0686	Belongs to the AlaDH PNT family
TPAU_RS08740	COG1522	sequence-specific DNA binding
TPAU_RS08750	COG1574	metal-dependent hydrolase with the TIM-barrel fold
TPAU_RS08755	COG1741	Belongs to the pirin family
TPAU_RS08775	COG2409	Drug exporters of the RND superfamily
TPAU_RS08780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPAU_RS08820	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TPAU_RS08830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TPAU_RS08835	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TPAU_RS08885	COG2890	protein-(glutamine-N5) methyltransferase activity
TPAU_RS08890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TPAU_RS08900	COG1058	Belongs to the CinA family
TPAU_RS08900	COG1546	Belongs to the CinA family
TPAU_RS08905	COG1396	sequence-specific DNA binding
TPAU_RS08910	COG1842	Phage shock protein A
TPAU_RS08940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TPAU_RS08955	COG0765	amino acid transport
TPAU_RS08960	COG0765	amino acid transport
TPAU_RS08965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TPAU_RS08970	COG1126	abc transporter atp-binding protein
TPAU_RS08975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPAU_RS08990	COG1196	nuclear chromosome segregation
TPAU_RS09000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TPAU_RS09005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TPAU_RS09010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TPAU_RS09040	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS09045	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS09050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TPAU_RS09060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TPAU_RS09065	COG1643	Atp-dependent helicase
TPAU_RS09080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TPAU_RS09170	COG0123	including yeast histone deacetylase and acetoin utilization protein
TPAU_RS09175	COG0045	succinate-CoA ligase (ADP-forming) activity
TPAU_RS09215	COG2826	transposase and inactivated derivatives, IS30 family
TPAU_RS09225	COG5006	permease, DMT superfamily
TPAU_RS09235	COG3590	peptidase
TPAU_RS09245	COG4303	Ethanolamine ammonia lyase large subunit
TPAU_RS09250	COG0531	amino acid
TPAU_RS09270	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS09285	COG1011	Hydrolase
TPAU_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS09310	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS09315	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS09325	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS09330	COG0477	Major facilitator Superfamily
TPAU_RS09345	COG3012	SEC-C Motif Domain Protein
TPAU_RS09365	COG4770	biotin carboxylase activity
TPAU_RS09380	COG4585	Histidine kinase
TPAU_RS09425	COG0756	dUTP diphosphatase activity
TPAU_RS09445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TPAU_RS09450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TPAU_RS09475	COG3253	May function as heme-dependent peroxidase
TPAU_RS09480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TPAU_RS09495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TPAU_RS09495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TPAU_RS09505	COG1937	Protein conserved in bacteria
TPAU_RS09525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TPAU_RS09530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TPAU_RS09535	COG0706	membrane insertase activity
TPAU_RS09570	COG0346	lactoylglutathione lyase activity
TPAU_RS09580	COG1216	Glycosyl transferase, family 2
TPAU_RS09585	COG1309	transcriptional regulator
TPAU_RS09610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TPAU_RS09625	COG1560	Kdo2-lipid A biosynthetic process
TPAU_RS09630	COG0438	transferase activity, transferring glycosyl groups
TPAU_RS09635	COG0494	nUDIX hydrolase
TPAU_RS09645	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TPAU_RS09660	COG1946	Acyl-CoA thioesterase
TPAU_RS09665	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TPAU_RS09685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TPAU_RS09705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TPAU_RS09715	COG0514	ATP-dependent DNA helicase (RecQ)
TPAU_RS09730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPAU_RS09740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TPAU_RS09750	COG2826	transposase and inactivated derivatives, IS30 family
TPAU_RS09765	COG0124	histidyl-tRNA synthetase
TPAU_RS09780	COG0640	Transcriptional regulator
TPAU_RS09790	COG0523	cobalamin synthesis protein
TPAU_RS09830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TPAU_RS09850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TPAU_RS09855	COG0444	Belongs to the ABC transporter superfamily
TPAU_RS09860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPAU_RS09890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPAU_RS09900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TPAU_RS09905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TPAU_RS09920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS09925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS09930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS09935	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS09950	COG1126	abc transporter atp-binding protein
TPAU_RS09955	COG0765	amino acid transport
TPAU_RS09960	COG2197	response regulator
TPAU_RS09965	COG4585	Histidine kinase
TPAU_RS09985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS09990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS10010	COG0156	8-amino-7-oxononanoate synthase activity
TPAU_RS10015	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TPAU_RS10020	COG0671	phosphoesterase, PA-phosphatase related
TPAU_RS10025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TPAU_RS10045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS10050	COG1752	Esterase of the alpha-beta hydrolase superfamily
TPAU_RS10065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TPAU_RS10090	COG0745	RESPONSE REGULATOR receiver
TPAU_RS10095	COG5002	protein histidine kinase activity
TPAU_RS10130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TPAU_RS10135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TPAU_RS10140	COG0131	Imidazoleglycerol-phosphate dehydratase
TPAU_RS10145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TPAU_RS10150	COG1953	Uracil, thiamine, allantoin
TPAU_RS10165	COG3257	ureidoglycine aminohydrolase activity
TPAU_RS10175	COG1414	Transcriptional regulator
TPAU_RS10185	COG1024	Enoyl-CoA hydratase
TPAU_RS10195	COG1024	Enoyl-CoA hydratase
TPAU_RS10200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TPAU_RS10215	COG0483	inositol monophosphate 1-phosphatase activity
TPAU_RS10220	COG0107	imidazoleglycerol-phosphate synthase activity
TPAU_RS10225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TPAU_RS10235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TPAU_RS10250	COG2971	BadF BadG BcrA BcrD
TPAU_RS10255	COG2814	Major facilitator Superfamily
TPAU_RS10260	COG2188	Transcriptional regulator
TPAU_RS10270	COG1126	abc transporter atp-binding protein
TPAU_RS10275	COG0765	amino acid transport
TPAU_RS10290	COG0159	tryptophan synthase activity
TPAU_RS10295	COG5001	Diguanylate cyclase
TPAU_RS10295	COG5002	protein histidine kinase activity
TPAU_RS10295	COG3447	MASE1 domain protein
TPAU_RS10300	COG5001	Diguanylate cyclase
TPAU_RS10310	COG0488	(ABC) transporter
TPAU_RS10315	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS10335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TPAU_RS10355	COG0584	glycerophosphoryl diester phosphodiesterase
TPAU_RS10380	COG3842	ATPase activity
TPAU_RS10390	COG1309	transcriptional regulator
TPAU_RS10395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TPAU_RS10405	COG0791	NLP P60 protein
TPAU_RS10405	COG3883	PFAM NLP P60 protein
TPAU_RS10410	COG0714	Associated with various cellular activities
TPAU_RS10430	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TPAU_RS10435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TPAU_RS10495	COG0583	DNA-binding transcription factor activity
TPAU_RS10520	COG3573	Dehydrogenase
TPAU_RS10530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TPAU_RS10555	COG0028	Belongs to the TPP enzyme family
TPAU_RS10565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TPAU_RS10580	COG5001	Diguanylate cyclase
TPAU_RS10590	COG0531	amino acid
TPAU_RS10600	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS10635	COG3265	gluconokinase activity
TPAU_RS10660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TPAU_RS10685	COG1968	undecaprenyl-diphosphatase activity
TPAU_RS10690	COG0583	DNA-binding transcription factor activity
TPAU_RS10720	COG0215	cysteine-tRNA ligase activity
TPAU_RS10740	COG0646	methionine synthase
TPAU_RS10740	COG1410	methionine synthase
TPAU_RS10745	COG0737	Belongs to the 5'-nucleotidase family
TPAU_RS10750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TPAU_RS10765	COG0140	phosphoribosyl-ATP diphosphatase activity
TPAU_RS10770	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TPAU_RS10785	COG1222	aaa ATPase
TPAU_RS10790	COG1131	(ABC) transporter
TPAU_RS10790	COG1716	ATPase activity
TPAU_RS10790	COG0842	Transport permease protein
TPAU_RS10815	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TPAU_RS10820	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TPAU_RS10830	COG0733	neurotransmitter:sodium symporter activity
TPAU_RS10850	COG2378	regulation of single-species biofilm formation
TPAU_RS10855	COG2378	regulation of single-species biofilm formation
TPAU_RS10860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TPAU_RS10890	COG0477	Major facilitator Superfamily
TPAU_RS10900	COG0300	oxidoreductase activity
TPAU_RS10930	COG0596	Alpha beta hydrolase
TPAU_RS10945	COG2814	Major facilitator Superfamily
TPAU_RS10950	COG0657	acetylesterase activity
TPAU_RS10955	COG1396	sequence-specific DNA binding
TPAU_RS10980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TPAU_RS11005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TPAU_RS11015	COG0463	Glycosyl transferase, family 2
TPAU_RS11040	COG1376	ErfK ybiS ycfS ynhG family protein
TPAU_RS11045	COG2072	flavoprotein involved in K transport
TPAU_RS11070	COG1454	alcohol dehydrogenase
TPAU_RS11095	COG2186	Transcriptional regulator
TPAU_RS11100	COG2807	transmembrane transport
TPAU_RS11110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TPAU_RS11140	COG1250	3-hydroxyacyl-CoA dehydrogenase
TPAU_RS11150	COG2124	cytochrome p450
TPAU_RS11155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TPAU_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS11170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TPAU_RS11175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TPAU_RS11180	COG0798	PFAM Bile acid sodium symporter
TPAU_RS11260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPAU_RS11265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPAU_RS11325	COG2354	Protein conserved in bacteria
TPAU_RS11350	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TPAU_RS11365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TPAU_RS11370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TPAU_RS11380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TPAU_RS11400	COG1063	alcohol dehydrogenase
TPAU_RS11450	COG2268	Band 7 protein
TPAU_RS11465	COG1309	transcriptional regulator
TPAU_RS11470	COG1819	glycosyl
TPAU_RS11485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TPAU_RS11490	COG1074	ATP-dependent DNA helicase activity
TPAU_RS11500	COG1011	Hydrolase
TPAU_RS11515	COG4762	Protein conserved in bacteria
TPAU_RS11540	COG1695	Transcriptional regulator
TPAU_RS11600	COG1253	flavin adenine dinucleotide binding
TPAU_RS11615	COG0739	heme binding
TPAU_RS11620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPAU_RS11625	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TPAU_RS11680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TPAU_RS11680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TPAU_RS11720	COG0653	protein targeting
TPAU_RS11725	COG2234	aminopeptidase activity
TPAU_RS11735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TPAU_RS11745	COG0746	molybdenum cofactor guanylyltransferase activity
TPAU_RS11750	COG0596	Alpha beta hydrolase
TPAU_RS11770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TPAU_RS11775	COG1309	transcriptional regulator
TPAU_RS11780	COG0300	oxidoreductase activity
TPAU_RS11820	COG2365	Tyrosine phosphatase family
TPAU_RS11855	COG1160	GTP binding
TPAU_RS11860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TPAU_RS11870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TPAU_RS11875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TPAU_RS11890	COG0494	nUDIX hydrolase
TPAU_RS11920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TPAU_RS11935	COG0647	UMP catabolic process
TPAU_RS11960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TPAU_RS11970	COG2835	tetraacyldisaccharide 4'-kinase activity
TPAU_RS11985	COG1131	(ABC) transporter
TPAU_RS11995	COG1309	transcriptional regulator
TPAU_RS12000	COG0165	Argininosuccinate lyase
TPAU_RS12005	COG0137	argininosuccinate synthase activity
TPAU_RS12010	COG1438	arginine binding
TPAU_RS12015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TPAU_RS12020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TPAU_RS12025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TPAU_RS12030	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TPAU_RS12060	COG0072	phenylalanine-tRNA ligase activity
TPAU_RS12060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPAU_RS12065	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TPAU_RS12090	COG2197	response regulator
TPAU_RS12105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TPAU_RS12130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPAU_RS12140	COG3973	AAA domain
TPAU_RS12180	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TPAU_RS12180	COG0237	dephospho-CoA kinase activity
TPAU_RS12190	COG0539	negative regulation of cytoplasmic translation
TPAU_RS12195	COG2226	methyltransferase
TPAU_RS12255	COG4260	virion core protein, lumpy skin disease virus
TPAU_RS12260	COG3422	double-strand break repair
TPAU_RS12285	COG0477	Major facilitator Superfamily
TPAU_RS12310	COG1902	pentaerythritol trinitrate reductase activity
TPAU_RS12315	COG0435	Glutathione S-transferase
TPAU_RS12370	COG3328	transposase activity
TPAU_RS12380	COG2801	Transposase and inactivated derivatives
TPAU_RS12420	COG3243	poly(R)-hydroxyalkanoic acid synthase
TPAU_RS12440	COG0705	Rhomboid family
TPAU_RS12455	COG1946	Acyl-CoA thioesterase
TPAU_RS12465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TPAU_RS12490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TPAU_RS12500	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS12510	COG1846	Transcriptional regulator
TPAU_RS12515	COG4977	sequence-specific DNA binding
TPAU_RS12525	COG2151	metal-sulfur cluster biosynthetic enzyme
TPAU_RS12540	COG0396	ATPase activity
TPAU_RS12565	COG1131	(ABC) transporter
TPAU_RS12595	COG1309	transcriptional regulator
TPAU_RS12610	COG0109	protoheme IX farnesyltransferase activity
TPAU_RS12620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TPAU_RS12635	COG0363	glucosamine-6-phosphate deaminase activity
TPAU_RS12670	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS12680	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
TPAU_RS12685	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TPAU_RS12695	COG0149	triose-phosphate isomerase activity
TPAU_RS12700	COG0126	phosphoglycerate kinase activity
TPAU_RS12705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TPAU_RS12715	COG1481	regulation of sporulation
TPAU_RS12725	COG1660	Displays ATPase and GTPase activities
TPAU_RS12735	COG0405	Gamma-glutamyltransferase
TPAU_RS12765	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS12785	COG3104	oligopeptide transport
TPAU_RS12795	COG1012	belongs to the aldehyde dehydrogenase family
TPAU_RS12805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TPAU_RS12810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TPAU_RS12810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TPAU_RS12845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TPAU_RS12850	COG0242	peptide deformylase activity
TPAU_RS12875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TPAU_RS12885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TPAU_RS12895	COG1758	RNA polymerase activity
TPAU_RS12910	COG0284	orotidine-5'-phosphate decarboxylase activity
TPAU_RS12920	COG0505	Belongs to the CarA family
TPAU_RS12960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TPAU_RS12965	COG0006	proline dipeptidase activity
TPAU_RS13005	COG2755	lipolytic protein G-D-S-L family
TPAU_RS13040	COG2801	Transposase and inactivated derivatives
TPAU_RS13065	COG0297	glycogen (starch) synthase activity
TPAU_RS13070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TPAU_RS13075	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TPAU_RS13080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TPAU_RS13090	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TPAU_RS13130	COG1090	epimerase
TPAU_RS13145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TPAU_RS13160	COG0252	asparaginase activity
TPAU_RS13185	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TPAU_RS13205	COG1799	cell septum assembly
TPAU_RS13210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TPAU_RS13220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TPAU_RS13225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TPAU_RS13230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TPAU_RS13245	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TPAU_RS13250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPAU_RS13255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TPAU_RS13265	COG0768	penicillin binding
TPAU_RS13275	COG0275	rRNA processing
TPAU_RS13280	COG2001	Belongs to the MraZ family
TPAU_RS13315	COG0142	geranyltranstransferase activity
TPAU_RS13320	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TPAU_RS13335	COG4604	ABC transporter, ATP-binding protein
TPAU_RS13355	COG2357	RelA SpoT domain protein
TPAU_RS13365	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TPAU_RS13380	COG1940	carbohydrate kinase activity
TPAU_RS13410	COG0438	transferase activity, transferring glycosyl groups
TPAU_RS13450	COG0442	prolyl-tRNA aminoacylation
TPAU_RS13455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TPAU_RS13485	COG2826	transposase and inactivated derivatives, IS30 family
TPAU_RS13500	COG4948	Mandelate Racemase Muconate Lactonizing
TPAU_RS13510	COG1053	succinate dehydrogenase
TPAU_RS13520	COG0179	Fumarylacetoacetate (FAA) hydrolase
TPAU_RS13560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TPAU_RS13560	COG3323	Protein of unknown function (DUF1653)
TPAU_RS13615	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TPAU_RS13630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPAU_RS13700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TPAU_RS13710	COG0358	DNA primase activity
TPAU_RS13715	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TPAU_RS13720	COG1278	Cold shock
TPAU_RS13730	COG0423	glycine-tRNA ligase activity
TPAU_RS13765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TPAU_RS13770	COG1846	Transcriptional regulator
TPAU_RS13775	COG1764	response to oxidative stress
TPAU_RS13795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TPAU_RS13800	COG1381	Involved in DNA repair and RecF pathway recombination
TPAU_RS13820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TPAU_RS13840	COG0484	heat shock protein binding
TPAU_RS13845	COG1420	regulation of RNA biosynthetic process
TPAU_RS13875	COG0175	sulfate reduction
TPAU_RS13895	COG4552	Acetyltransferase involved in intracellular survival and related
TPAU_RS13900	COG3842	ATPase activity
TPAU_RS13905	COG4208	sulfate ABC transporter
TPAU_RS13915	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TPAU_RS13925	COG3387	PFAM Glycoside hydrolase 15-related
TPAU_RS13945	COG2070	2-Nitropropane dioxygenase
TPAU_RS13960	COG0481	GTPase activity
TPAU_RS13970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TPAU_RS13975	COG1012	belongs to the aldehyde dehydrogenase family
TPAU_RS13995	COG1305	Transglutaminase-like
TPAU_RS14005	COG2308	Evidence 4 Homologs of previously reported genes of
TPAU_RS14010	COG0268	Binds directly to 16S ribosomal RNA
TPAU_RS14025	COG1555	photosystem II stabilization
TPAU_RS14025	COG1596	polysaccharide export
TPAU_RS14030	COG1307	EDD domain protein, DegV family
TPAU_RS14035	COG2755	lipolytic protein G-D-S-L family
TPAU_RS14040	COG0406	alpha-ribazole phosphatase activity
TPAU_RS14045	COG0799	negative regulation of ribosome biogenesis
TPAU_RS14050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TPAU_RS14060	COG0542	response to heat
TPAU_RS14075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TPAU_RS14130	COG3547	Transposase (IS116 IS110 IS902 family)
TPAU_RS14145	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS14150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TPAU_RS14165	COG1024	Enoyl-CoA hydratase
TPAU_RS14170	COG1309	transcriptional regulator
TPAU_RS14180	COG1461	Dihydroxyacetone kinase
TPAU_RS14185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TPAU_RS14195	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TPAU_RS14215	COG1181	Belongs to the D-alanine--D-alanine ligase family
TPAU_RS14220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TPAU_RS14225	COG1920	GTP binding
TPAU_RS14230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TPAU_RS14245	COG0066	3-isopropylmalate dehydratase activity
TPAU_RS14250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TPAU_RS14280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TPAU_RS14290	COG0179	Fumarylacetoacetate (FAA) hydrolase
TPAU_RS14295	COG2271	Major facilitator Superfamily
TPAU_RS14300	COG0473	3-isopropylmalate dehydrogenase activity
TPAU_RS14315	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS14335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TPAU_RS14340	COG0440	acetolactate synthase activity
TPAU_RS14355	COG0129	dihydroxy-acid dehydratase activity
TPAU_RS14370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPAU_RS14380	COG0205	6-phosphofructokinase activity
TPAU_RS14385	COG2197	response regulator
TPAU_RS14390	COG4585	Histidine kinase
TPAU_RS14405	COG1959	2 iron, 2 sulfur cluster binding
TPAU_RS14410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TPAU_RS14425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPAU_RS14435	COG1012	belongs to the aldehyde dehydrogenase family
TPAU_RS14450	COG3547	Transposase (IS116 IS110 IS902 family)
TPAU_RS14455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TPAU_RS14475	COG2072	flavoprotein involved in K transport
TPAU_RS14480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TPAU_RS14495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TPAU_RS14495	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TPAU_RS14520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TPAU_RS14565	COG0482	sulfurtransferase activity
TPAU_RS14595	COG3590	peptidase
TPAU_RS14600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TPAU_RS14610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TPAU_RS14650	COG0110	maltose O-acetyltransferase activity
TPAU_RS14665	COG0024	Methionine aminopeptidase
TPAU_RS14680	COG0436	Aminotransferase
TPAU_RS14695	COG2226	methyltransferase
TPAU_RS14710	COG1119	ATPase activity
TPAU_RS14715	COG1523	belongs to the glycosyl hydrolase 13 family
TPAU_RS14720	COG0560	Phosphoserine phosphatase
TPAU_RS14720	COG3830	Belongs to the UPF0237 family
TPAU_RS14790	COG2826	transposase and inactivated derivatives, IS30 family
TPAU_RS14805	COG1309	transcriptional regulator
TPAU_RS14820	COG2351	hydroxyisourate hydrolase activity
TPAU_RS14825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TPAU_RS14840	COG2233	PERMEase
TPAU_RS14845	COG0402	S-adenosylhomocysteine deaminase activity
TPAU_RS14850	COG3835	regulator
TPAU_RS14855	COG2080	2 iron, 2 sulfur cluster binding
TPAU_RS14855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TPAU_RS14860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPAU_RS14865	COG1780	Probably involved in ribonucleotide reductase function
TPAU_RS14875	COG0431	NADPH-dependent FMN reductase
TPAU_RS14900	COG1054	Belongs to the UPF0176 family
TPAU_RS14910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPAU_RS14935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TPAU_RS14945	COG3708	Transcriptional regulator
TPAU_RS14945	COG2207	Transcriptional regulator
TPAU_RS14955	COG0640	Transcriptional regulator
TPAU_RS15000	COG4249	Peptidase C14 caspase catalytic subunit p20
TPAU_RS15005	COG3634	alkyl hydroperoxide reductase activity
TPAU_RS15035	COG2610	gluconate transmembrane transporter activity
TPAU_RS15040	COG0800	Aldolase
TPAU_RS15045	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TPAU_RS15060	COG1414	Transcriptional regulator
TPAU_RS15075	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TPAU_RS15085	COG3012	SEC-C Motif Domain Protein
TPAU_RS15105	COG2814	Major facilitator Superfamily
TPAU_RS15115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TPAU_RS15120	COG2177	Part of the ABC transporter FtsEX involved in
TPAU_RS15125	COG2884	Cell division ATP-binding protein ftsE
TPAU_RS15135	COG0668	transmembrane transport
TPAU_RS15140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TPAU_RS15150	COG0483	inositol monophosphate 1-phosphatase activity
TPAU_RS15155	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS15160	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS15165	COG0415	Belongs to the DNA photolyase family
TPAU_RS15170	COG1388	LysM domain
TPAU_RS15175	COG2814	Major facilitator Superfamily
TPAU_RS15180	COG0730	response to heat
TPAU_RS15185	COG0110	maltose O-acetyltransferase activity
TPAU_RS15200	COG1615	UPF0182 protein
TPAU_RS15210	COG3480	Lon protease (S16) C-terminal proteolytic domain
TPAU_RS15230	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS15280	COG3842	ATPase activity
TPAU_RS15310	COG0738	Major facilitator superfamily
TPAU_RS15315	COG1609	Transcriptional regulator
TPAU_RS15330	COG0058	SHG alpha-glucan phosphorylase activity
TPAU_RS15355	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS15365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TPAU_RS15370	COG1131	(ABC) transporter
TPAU_RS15395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TPAU_RS15425	COG2249	NAD(P)H dehydrogenase (quinone) activity
TPAU_RS15500	COG2814	Major facilitator Superfamily
TPAU_RS15510	COG0012	GTP binding
TPAU_RS15530	COG1966	Carbon starvation protein
TPAU_RS15540	COG3547	Transposase (IS116 IS110 IS902 family)
TPAU_RS15550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TPAU_RS15550	COG2169	Transcriptional regulator
TPAU_RS15560	COG1322	Protein conserved in bacteria
TPAU_RS15580	COG1570	exodeoxyribonuclease VII activity
TPAU_RS15585	COG1722	exodeoxyribonuclease VII activity
TPAU_RS15620	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TPAU_RS15620	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TPAU_RS15640	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TPAU_RS15650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TPAU_RS15680	COG1116	anion transmembrane transporter activity
TPAU_RS15685	COG4521	taurine ABC transporter
TPAU_RS15690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPAU_RS15705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TPAU_RS15710	COG1331	Highly conserved protein containing a thioredoxin domain
TPAU_RS15715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TPAU_RS15725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TPAU_RS15740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TPAU_RS15770	COG2755	lipolytic protein G-D-S-L family
TPAU_RS15800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TPAU_RS15805	COG2076	Multidrug Resistance protein
TPAU_RS15830	COG0148	phosphopyruvate hydratase activity
TPAU_RS15850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPAU_RS15855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPAU_RS15870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TPAU_RS15875	COG1034	ATP synthesis coupled electron transport
TPAU_RS15880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TPAU_RS15885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPAU_RS15890	COG0839	Belongs to the complex I subunit 6 family
TPAU_RS15895	COG0713	ATP synthesis coupled electron transport
TPAU_RS15920	COG1309	transcriptional regulator
TPAU_RS15945	COG1073	alpha beta
TPAU_RS15955	COG3956	TIGRFAM MazG family protein
TPAU_RS15980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TPAU_RS15990	COG1393	Belongs to the ArsC family
TPAU_RS16015	COG2837	iron assimilation
TPAU_RS16025	COG0542	response to heat
TPAU_RS16045	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
TPAU_RS16055	COG0193	aminoacyl-tRNA hydrolase activity
TPAU_RS16065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TPAU_RS16075	COG1280	lysine exporter protein (LysE YggA)
TPAU_RS16090	COG2801	Transposase and inactivated derivatives
TPAU_RS16115	COG0488	(ABC) transporter
TPAU_RS16135	COG3012	SEC-C Motif Domain Protein
TPAU_RS16140	COG0488	(ABC) transporter
TPAU_RS16145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TPAU_RS16155	COG3583	domain protein
TPAU_RS16160	COG0084	hydrolase, TatD family'
TPAU_RS16205	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TPAU_RS16210	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TPAU_RS16215	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TPAU_RS16240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TPAU_RS16250	COG3547	Transposase (IS116 IS110 IS902 family)
TPAU_RS16260	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TPAU_RS16270	COG0596	Alpha beta hydrolase
TPAU_RS16275	COG5473	translation initiation factor activity
TPAU_RS16280	COG5473	translation initiation factor activity
TPAU_RS16300	COG1733	regulation of RNA biosynthetic process
TPAU_RS16305	COG3384	dioxygenase
TPAU_RS16320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TPAU_RS16330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TPAU_RS16335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TPAU_RS16375	COG1970	mechanosensitive ion channel activity
TPAU_RS16405	COG0521	Mo-molybdopterin cofactor biosynthetic process
TPAU_RS16410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPAU_RS16425	COG2860	membrane
TPAU_RS16435	COG0254	rRNA binding
TPAU_RS16445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TPAU_RS16455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TPAU_RS16460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TPAU_RS16485	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TPAU_RS16500	COG0640	Transcriptional regulator
TPAU_RS16535	COG2814	Major facilitator Superfamily
TPAU_RS16565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TPAU_RS16570	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS16585	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS16595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TPAU_RS16605	COG1285	pathogenesis
TPAU_RS16610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPAU_RS16615	COG1116	anion transmembrane transporter activity
TPAU_RS16620	COG0739	heme binding
TPAU_RS16645	COG4424	Sulfotransferase
TPAU_RS16660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TPAU_RS16665	COG3119	arylsulfatase activity
TPAU_RS16675	COG0166	Belongs to the GPI family
TPAU_RS16700	COG2364	Membrane
TPAU_RS16705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TPAU_RS16730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TPAU_RS16735	COG1218	3'(2'),5'-bisphosphate nucleotidase
TPAU_RS16770	COG0328	RNA-DNA hybrid ribonuclease activity
TPAU_RS16780	COG1408	metallophosphoesterase
TPAU_RS16810	COG2072	flavoprotein involved in K transport
TPAU_RS16890	COG0101	tRNA pseudouridine synthase activity
TPAU_RS16900	COG0202	RNA polymerase activity
TPAU_RS16905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TPAU_RS16910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TPAU_RS16915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TPAU_RS16920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TPAU_RS16930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TPAU_RS16935	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TPAU_RS16950	COG0789	Transcriptional regulator
TPAU_RS16955	COG1301	dicarboxylic acid transport
TPAU_RS16965	COG0563	adenylate kinase activity
TPAU_RS16975	COG0200	Binds to the 23S rRNA
TPAU_RS16980	COG1841	ribosomal large subunit assembly
TPAU_RS16990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TPAU_RS16995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TPAU_RS17015	COG0829	nickel cation binding
TPAU_RS17020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TPAU_RS17025	COG0830	nickel cation binding
TPAU_RS17035	COG0832	Belongs to the urease beta subunit family
TPAU_RS17040	COG0831	urea catabolic process
TPAU_RS17080	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TPAU_RS17085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TPAU_RS17090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TPAU_RS17105	COG0513	Belongs to the DEAD box helicase family
TPAU_RS17115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TPAU_RS17120	COG0255	Belongs to the universal ribosomal protein uL29 family
TPAU_RS17125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TPAU_RS17130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TPAU_RS17140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TPAU_RS17145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TPAU_RS17150	COG0089	rRNA binding
TPAU_RS17155	COG0088	Forms part of the polypeptide exit tunnel
TPAU_RS17165	COG0051	transcription antitermination factor activity, RNA binding
TPAU_RS17190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TPAU_RS17210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TPAU_RS17280	COG2826	transposase and inactivated derivatives, IS30 family
TPAU_RS17315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TPAU_RS17325	COG0049	tRNA binding
TPAU_RS17330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TPAU_RS17345	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TPAU_RS17475	COG1131	(ABC) transporter
TPAU_RS17495	COG3547	Transposase (IS116 IS110 IS902 family)
TPAU_RS17510	COG2814	Major facilitator Superfamily
TPAU_RS17525	COG2197	response regulator
TPAU_RS17535	COG2132	Multicopper oxidase
TPAU_RS17555	COG2072	flavoprotein involved in K transport
TPAU_RS17570	COG0657	acetylesterase activity
TPAU_RS17575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TPAU_RS17585	COG0477	Major facilitator Superfamily
TPAU_RS17590	COG1984	allophanate hydrolase subunit 2
TPAU_RS17615	COG1595	DNA-templated transcription, initiation
TPAU_RS17635	COG0438	transferase activity, transferring glycosyl groups
TPAU_RS17640	COG3842	ATPase activity
TPAU_RS17645	COG1653	transport
TPAU_RS17680	COG2197	response regulator
TPAU_RS17710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TPAU_RS17730	COG0456	acetyltransferase
TPAU_RS17735	COG0745	RESPONSE REGULATOR receiver
TPAU_RS17745	COG2897	thiosulfate sulfurtransferase activity
TPAU_RS17755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TPAU_RS17775	COG0572	uridine kinase
TPAU_RS17810	COG4044	May play a role in the intracellular transport of hydrophobic ligands
TPAU_RS17835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TPAU_RS17840	COG4988	ABC transporter
TPAU_RS17845	COG1294	oxidase, subunit
TPAU_RS17865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TPAU_RS17880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TPAU_RS17915	COG1090	epimerase
TPAU_RS17930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TPAU_RS17945	COG5343	regulation of RNA biosynthetic process
TPAU_RS17960	COG1113	amino acid transport
TPAU_RS17980	COG1301	dicarboxylic acid transport
TPAU_RS17985	COG3290	protein histidine kinase activity
TPAU_RS17990	COG4565	transcriptional regulatory protein
TPAU_RS18015	COG0747	negative chemotaxis
TPAU_RS18030	COG0601	transmembrane transport
TPAU_RS18035	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS18050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TPAU_RS18055	COG3383	formate dehydrogenase (NAD+) activity
TPAU_RS18060	COG1113	amino acid transport
TPAU_RS18065	COG1362	aminopeptidase activity
TPAU_RS18070	COG0047	phosphoribosylformylglycinamidine synthase activity
TPAU_RS18075	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TPAU_RS18090	COG0386	Belongs to the glutathione peroxidase family
TPAU_RS18100	COG0477	Major facilitator Superfamily
TPAU_RS18115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TPAU_RS18125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TPAU_RS18155	COG2205	protein histidine kinase activity
TPAU_RS18160	COG0745	RESPONSE REGULATOR receiver
TPAU_RS18175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TPAU_RS18195	COG1024	Enoyl-CoA hydratase
TPAU_RS18215	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TPAU_RS18225	COG1305	Transglutaminase-like
TPAU_RS18235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TPAU_RS18270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TPAU_RS18275	COG0788	formyltetrahydrofolate deformylase activity
TPAU_RS18280	COG0406	alpha-ribazole phosphatase activity
TPAU_RS18285	COG0596	Alpha beta hydrolase
TPAU_RS18305	COG2733	membrane
TPAU_RS18310	COG2326	polyphosphate kinase activity
TPAU_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS18325	COG0583	DNA-binding transcription factor activity
TPAU_RS18330	COG2226	methyltransferase
TPAU_RS18335	COG0492	ferredoxin-NADP+ reductase activity
TPAU_RS18345	COG2224	Isocitrate lyase
TPAU_RS18365	COG5285	phytanoyl-CoA dioxygenase
TPAU_RS18380	COG1505	serine-type exopeptidase activity
TPAU_RS18410	COG2326	polyphosphate kinase activity
TPAU_RS18425	COG1535	isochorismatase
TPAU_RS18425	COG3433	isochorismatase activity
TPAU_RS18430	COG1021	2,3-dihydroxybenzoate-AMP ligase
TPAU_RS18435	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS18440	COG2375	cellular response to nickel ion
TPAU_RS18445	COG1132	(ABC) transporter
TPAU_RS18450	COG1132	(ABC) transporter
TPAU_RS18460	COG3486	L-lysine 6-monooxygenase (NADPH) activity
TPAU_RS18465	COG1535	isochorismatase
TPAU_RS18465	COG3433	isochorismatase activity
TPAU_RS18470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TPAU_RS18485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPAU_RS18490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS18510	COG0326	Molecular chaperone. Has ATPase activity
TPAU_RS18545	COG2261	transglycosylase associated protein
TPAU_RS18550	COG0688	phosphatidylethanolamine metabolic process
TPAU_RS18560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPAU_RS18575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TPAU_RS18575	COG2111	Na H antiporter
TPAU_RS18580	COG1006	Multisubunit Na H antiporter MnhC subunit
TPAU_RS18585	COG0651	ATP synthesis coupled electron transport
TPAU_RS18600	COG1320	monovalent cation:proton antiporter activity
TPAU_RS18605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TPAU_RS18630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TPAU_RS18635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPAU_RS18665	COG0456	acetyltransferase
TPAU_RS18680	COG4555	ABC transporter
TPAU_RS18690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TPAU_RS18700	COG0351	phosphomethylpyrimidine kinase
TPAU_RS18720	COG2197	response regulator
TPAU_RS18725	COG0477	Major facilitator Superfamily
TPAU_RS18730	COG1403	HNH endonuclease
TPAU_RS18735	COG2022	thiamine diphosphate biosynthetic process
TPAU_RS18745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TPAU_RS18745	COG2022	thiamine diphosphate biosynthetic process
TPAU_RS18750	COG0352	thiamine-phosphate diphosphorylase activity
TPAU_RS18755	COG1733	regulation of RNA biosynthetic process
TPAU_RS18775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TPAU_RS18785	COG1120	ATPase activity
TPAU_RS18790	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPAU_RS18795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPAU_RS18810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TPAU_RS18820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS18830	COG1132	(ABC) transporter
TPAU_RS18850	COG0657	acetylesterase activity
TPAU_RS18875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPAU_RS18880	COG1120	ATPase activity
TPAU_RS18885	COG2124	cytochrome p450
TPAU_RS18935	COG4941	Belongs to the sigma-70 factor family
TPAU_RS18940	COG1088	dTDP-glucose 4,6-dehydratase activity
TPAU_RS18945	COG1309	transcriptional regulator
TPAU_RS18950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPAU_RS18955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPAU_RS18990	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS18995	COG3971	2-oxopent-4-enoate hydratase activity
TPAU_RS19015	COG1414	Transcriptional regulator
TPAU_RS19030	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS19035	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS19040	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS19045	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TPAU_RS19055	COG1793	dna ligase
TPAU_RS19065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS19080	COG2070	2-Nitropropane dioxygenase
TPAU_RS19085	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS19105	COG2124	cytochrome p450
TPAU_RS19110	COG0183	Belongs to the thiolase family
TPAU_RS19115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TPAU_RS19120	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS19125	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS19130	COG1250	3-hydroxyacyl-CoA dehydrogenase
TPAU_RS19130	COG1024	Enoyl-CoA hydratase
TPAU_RS19155	COG0745	RESPONSE REGULATOR receiver
TPAU_RS19160	COG0183	Belongs to the thiolase family
TPAU_RS19165	COG1309	transcriptional regulator
TPAU_RS19170	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS19175	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS19180	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS19185	COG1024	Enoyl-CoA hydratase
TPAU_RS19190	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS19200	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS19210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TPAU_RS19215	COG0346	lactoylglutathione lyase activity
TPAU_RS19220	COG2267	carboxylic ester hydrolase activity
TPAU_RS19225	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS19230	COG1053	succinate dehydrogenase
TPAU_RS19240	COG1053	succinate dehydrogenase
TPAU_RS19245	COG4638	Rieske (2fe-2S)
TPAU_RS19260	COG2030	dehydratase
TPAU_RS19275	COG1960	acyl-CoA dehydrogenase activity
TPAU_RS19280	COG2030	dehydratase
TPAU_RS19345	COG2508	Transcriptional regulator
TPAU_RS19350	COG2072	flavoprotein involved in K transport
TPAU_RS19370	COG0470	DNA polymerase III
TPAU_RS19380	COG1754	DNA topoisomerase type I activity
TPAU_RS19380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TPAU_RS19390	COG2826	transposase and inactivated derivatives, IS30 family
TPAU_RS19400	COG1278	Cold shock
TPAU_RS19405	COG1111	helicase
TPAU_RS19405	COG1205	dead DEAH box helicase
TPAU_RS19500	COG3547	Transposase (IS116 IS110 IS902 family)
TPAU_RS19505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TPAU_RS19545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPAU_RS19550	COG0601	transmembrane transport
TPAU_RS19555	COG4166	transmembrane transport
TPAU_RS19560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TPAU_RS19575	COG1131	(ABC) transporter
TPAU_RS19610	COG0477	Major facilitator Superfamily
TPAU_RS19615	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TPAU_RS19625	COG2267	carboxylic ester hydrolase activity
TPAU_RS19635	COG0494	nUDIX hydrolase
TPAU_RS19660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPAU_RS19695	COG1024	Enoyl-CoA hydratase
TPAU_RS19710	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
TPAU_RS19715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TPAU_RS19735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TPAU_RS19740	COG3959	Transketolase, thiamine diphosphate binding domain
TPAU_RS19750	COG1012	belongs to the aldehyde dehydrogenase family
TPAU_RS19790	COG1408	metallophosphoesterase
TPAU_RS19795	COG1610	YqeY-like protein
TPAU_RS19805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TPAU_RS19810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TPAU_RS19815	COG1764	response to oxidative stress
TPAU_RS19840	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS19860	COG0768	penicillin binding
TPAU_RS19870	COG0135	phosphoribosylanthranilate isomerase activity
TPAU_RS19890	COG1528	Iron-storage protein
TPAU_RS19895	COG1309	transcriptional regulator
TPAU_RS19925	COG3251	PFAM MbtH domain protein
TPAU_RS19940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TPAU_RS19945	COG0697	spore germination
TPAU_RS19950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TPAU_RS19955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TPAU_RS19955	COG1017	nitric oxide dioxygenase activity
TPAU_RS19990	COG0477	Major facilitator Superfamily
TPAU_RS20000	COG0697	spore germination
TPAU_RS20010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TPAU_RS20020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TPAU_RS20050	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPAU_RS20055	COG0564	pseudouridine synthase activity
TPAU_RS20070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TPAU_RS20090	COG1785	Belongs to the alkaline phosphatase family
TPAU_RS20105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TPAU_RS20135	COG0596	Alpha beta hydrolase
TPAU_RS20165	COG0640	Transcriptional regulator
TPAU_RS20180	COG1228	amidohydrolase
TPAU_RS20185	COG0477	Major facilitator Superfamily
TPAU_RS20190	COG1522	sequence-specific DNA binding
TPAU_RS20200	COG1793	dna ligase
TPAU_RS20205	COG2318	DinB family
TPAU_RS20215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TPAU_RS20225	COG2409	Drug exporters of the RND superfamily
TPAU_RS20260	COG0287	Prephenate dehydrogenase
TPAU_RS20280	COG2826	transposase and inactivated derivatives, IS30 family
TPAU_RS20365	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TPAU_RS20385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TPAU_RS20405	COG4977	sequence-specific DNA binding
TPAU_RS20450	COG2826	transposase and inactivated derivatives, IS30 family
TPAU_RS20525	COG1216	Glycosyl transferase, family 2
TPAU_RS20530	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS20555	COG1476	TRANSCRIPTIONal
TPAU_RS20565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TPAU_RS20570	COG1012	belongs to the aldehyde dehydrogenase family
TPAU_RS20575	COG0006	proline dipeptidase activity
TPAU_RS20580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TPAU_RS20585	COG1473	amidohydrolase
TPAU_RS20605	COG1309	transcriptional regulator
TPAU_RS20610	COG0277	FAD linked oxidase domain protein
TPAU_RS20615	COG1028	Short-chain dehydrogenase reductase Sdr
TPAU_RS20625	COG4221	oxidoreductase activity
TPAU_RS20630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPAU_RS20660	COG1122	ATPase activity
TPAU_RS20665	COG1268	BioY protein
TPAU_RS20675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TPAU_RS20720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TPAU_RS20760	COG1174	glycine betaine transport
TPAU_RS20785	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TPAU_RS20805	COG0300	oxidoreductase activity
TPAU_RS20830	COG0359	binds to the 23S rRNA
TPAU_RS20835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TPAU_RS20845	COG0360	Binds together with S18 to 16S ribosomal RNA
TPAU_RS20855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPAU_RS20910	COG0183	Belongs to the thiolase family
TPAU_RS20915	COG1250	3-hydroxyacyl-CoA dehydrogenase
TPAU_RS20915	COG1024	Enoyl-CoA hydratase
TPAU_RS20925	COG1024	Enoyl-CoA hydratase
TPAU_RS20955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TPAU_RS20970	COG1260	myo-inositol-1-phosphate synthase
TPAU_RS20980	COG1297	OPT oligopeptide transporter protein
TPAU_RS20985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPAU_RS20990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TPAU_RS21010	COG2814	Major facilitator Superfamily
TPAU_RS21015	COG4221	oxidoreductase activity
TPAU_RS21020	COG1940	carbohydrate kinase activity
TPAU_RS21020	COG1846	Transcriptional regulator
TPAU_RS21025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TPAU_RS21035	COG0800	Aldolase
TPAU_RS21040	COG4214	carbohydrate transport
TPAU_RS21050	COG4213	ABC transporter substrate-binding protein
TPAU_RS21060	COG0495	leucyl-tRNA aminoacylation
TPAU_RS21085	COG1678	Uncharacterized ACR, COG1678
TPAU_RS21105	COG0617	tRNA 3'-terminal CCA addition
TPAU_RS21130	COG0519	Catalyzes the synthesis of GMP from XMP
TPAU_RS21135	COG1012	belongs to the aldehyde dehydrogenase family
TPAU_RS21140	COG1595	DNA-templated transcription, initiation
TPAU_RS21160	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPAU_RS21160	COG3409	Peptidoglycan-binding domain 1 protein
TPAU_RS21175	COG1192	Involved in chromosome partitioning
TPAU_RS21180	COG0357	Ribosomal RNA small subunit methyltransferase G
TPAU_RS21195	COG0594	ribonuclease P activity
TPAU_RS21205	COG0592	DNA-directed DNA polymerase activity
TPAU_RS21675	COG2385	sporulation resulting in formation of a cellular spore
TPAU_RS21690	COG2233	PERMEase
TPAU_RS21760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TPAU_RS21800	COG1309	transcriptional regulator
TPAU_RS21885	COG0318	PFAM AMP-dependent synthetase and ligase
TPAU_RS21890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TPAU_RS21890	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
TPAU_RS21980	COG2259	Doxx family
TPAU_RS22035	COG0745	RESPONSE REGULATOR receiver