locus-tag	class	description
LK411_RS00015	COG4974	Belongs to the 'phage' integrase family
LK411_RS00135	COG1674	ftsk spoiiie
LK411_RS00210	COG1285	pathogenesis
LK411_RS00230	COG0531	amino acid
LK411_RS00240	COG4303	Ethanolamine ammonia lyase large subunit
LK411_RS00270	COG0435	Glutathione S-transferase
LK411_RS00275	COG1902	pentaerythritol trinitrate reductase activity
LK411_RS00325	COG3422	double-strand break repair
LK411_RS00330	COG4260	virion core protein, lumpy skin disease virus
LK411_RS00395	COG3842	ATPase activity
LK411_RS00400	COG0395	ABC-type sugar transport system, permease component
LK411_RS00410	COG2182	Extracellular solute-binding protein
LK411_RS00420	COG1063	alcohol dehydrogenase
LK411_RS00430	COG1070	Carbohydrate kinase
LK411_RS00440	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LK411_RS00440	COG0237	dephospho-CoA kinase activity
LK411_RS00450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK411_RS00480	COG3973	AAA domain
LK411_RS00500	COG0596	Alpha beta hydrolase
LK411_RS00510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK411_RS00540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LK411_RS00560	COG1522	sequence-specific DNA binding
LK411_RS00570	COG2233	PERMEase
LK411_RS00600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LK411_RS00605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK411_RS00605	COG0072	phenylalanine-tRNA ligase activity
LK411_RS00645	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LK411_RS00650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LK411_RS00655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK411_RS00660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK411_RS00665	COG1438	arginine binding
LK411_RS00670	COG0137	argininosuccinate synthase activity
LK411_RS00675	COG0165	Argininosuccinate lyase
LK411_RS00680	COG1309	transcriptional regulator
LK411_RS00690	COG1131	(ABC) transporter
LK411_RS00710	COG2835	tetraacyldisaccharide 4'-kinase activity
LK411_RS00725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LK411_RS00750	COG0647	UMP catabolic process
LK411_RS00785	COG0504	CTP synthase activity
LK411_RS00790	COG0494	nUDIX hydrolase
LK411_RS00805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LK411_RS00810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LK411_RS00825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LK411_RS00830	COG1160	GTP binding
LK411_RS00840	COG2186	Transcriptional regulator
LK411_RS00875	COG2365	Tyrosine phosphatase family
LK411_RS00895	COG2249	NAD(P)H dehydrogenase (quinone) activity
LK411_RS00915	COG0596	Alpha beta hydrolase
LK411_RS00925	COG2234	aminopeptidase activity
LK411_RS00930	COG0653	protein targeting
LK411_RS00945	COG1716	ATPase activity
LK411_RS00970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LK411_RS00970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LK411_RS00985	COG1403	HNH endonuclease
LK411_RS01035	COG1120	ATPase activity
LK411_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK411_RS01055	COG1253	flavin adenine dinucleotide binding
LK411_RS01145	COG4762	Protein conserved in bacteria
LK411_RS01170	COG1074	ATP-dependent DNA helicase activity
LK411_RS01175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LK411_RS01190	COG1819	glycosyl
LK411_RS01195	COG1309	transcriptional regulator
LK411_RS01225	COG2268	Band 7 protein
LK411_RS01265	COG1464	Belongs to the NlpA lipoprotein family
LK411_RS01275	COG1063	alcohol dehydrogenase
LK411_RS01315	COG0297	glycogen (starch) synthase activity
LK411_RS01320	COG0438	transferase activity, transferring glycosyl groups
LK411_RS01325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LK411_RS01335	COG0438	transferase activity, transferring glycosyl groups
LK411_RS01340	COG0736	holo-[acyl-carrier-protein] synthase activity
LK411_RS01350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LK411_RS01360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LK411_RS01395	COG2354	Protein conserved in bacteria
LK411_RS01415	COG0477	Major facilitator Superfamily
LK411_RS01420	COG1280	lysine exporter protein (LysE YggA)
LK411_RS01435	COG2186	Transcriptional regulator
LK411_RS01440	COG0477	Major facilitator Superfamily
LK411_RS01445	COG1984	allophanate hydrolase subunit 2
LK411_RS01460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK411_RS01485	COG0798	PFAM Bile acid sodium symporter
LK411_RS01490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK411_RS01505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LK411_RS01515	COG2807	transmembrane transport
LK411_RS01520	COG2186	Transcriptional regulator
LK411_RS01540	COG1454	alcohol dehydrogenase
LK411_RS01565	COG2072	flavoprotein involved in K transport
LK411_RS01570	COG1376	ErfK ybiS ycfS ynhG family protein
LK411_RS01595	COG0463	Glycosyl transferase, family 2
LK411_RS01605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK411_RS01620	COG2186	Transcriptional regulator
LK411_RS01625	COG0247	lactate metabolic process
LK411_RS01630	COG1139	Iron-sulfur cluster binding protein
LK411_RS01635	COG1556	Lactate utilization protein
LK411_RS01675	COG1396	sequence-specific DNA binding
LK411_RS01685	COG2814	Major facilitator Superfamily
LK411_RS01690	COG3467	pyridoxamine 5'-phosphate
LK411_RS01725	COG0673	inositol 2-dehydrogenase activity
LK411_RS01730	COG1879	ABC-type sugar transport system periplasmic component
LK411_RS01735	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK411_RS01740	COG1129	ABC transporter
LK411_RS01750	COG1940	carbohydrate kinase activity
LK411_RS01770	COG0300	oxidoreductase activity
LK411_RS01780	COG0477	Major facilitator Superfamily
LK411_RS01815	COG2378	regulation of single-species biofilm formation
LK411_RS01845	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LK411_RS01850	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LK411_RS01880	COG1131	(ABC) transporter
LK411_RS01880	COG0842	Transport permease protein
LK411_RS01880	COG1716	ATPase activity
LK411_RS01885	COG1222	aaa ATPase
LK411_RS01900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LK411_RS01905	COG0140	phosphoribosyl-ATP diphosphatase activity
LK411_RS01920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK411_RS01935	COG1410	methionine synthase
LK411_RS01935	COG0646	methionine synthase
LK411_RS01950	COG0215	cysteine-tRNA ligase activity
LK411_RS01965	COG3220	belongs to the UPF0276 family
LK411_RS01990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK411_RS01995	COG0583	DNA-binding transcription factor activity
LK411_RS02000	COG1968	undecaprenyl-diphosphatase activity
LK411_RS02025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK411_RS02060	COG3265	gluconokinase activity
LK411_RS02115	COG0531	amino acid
LK411_RS02125	COG5001	Diguanylate cyclase
LK411_RS02135	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
LK411_RS02145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK411_RS02155	COG0028	Belongs to the TPP enzyme family
LK411_RS02175	COG0346	lactoylglutathione lyase activity
LK411_RS02210	COG2188	Transcriptional regulator
LK411_RS02215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK411_RS02215	COG2022	thiamine diphosphate biosynthetic process
LK411_RS02270	COG0596	Alpha beta hydrolase
LK411_RS02310	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LK411_RS02315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LK411_RS02335	COG0714	Associated with various cellular activities
LK411_RS02340	COG0791	NLP P60 protein
LK411_RS02340	COG3883	PFAM NLP P60 protein
LK411_RS02350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LK411_RS02355	COG1309	transcriptional regulator
LK411_RS02380	COG0714	Associated with various cellular activities
LK411_RS02390	COG3552	Protein containing von Willebrand factor type A (VWA) domain
LK411_RS02395	COG0584	glycerophosphoryl diester phosphodiesterase
LK411_RS02425	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS02430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LK411_RS02435	COG1309	transcriptional regulator
LK411_RS02440	COG1819	glycosyl
LK411_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS02460	COG0488	(ABC) transporter
LK411_RS02480	COG0159	tryptophan synthase activity
LK411_RS02495	COG0765	amino acid transport
LK411_RS02500	COG1126	abc transporter atp-binding protein
LK411_RS02510	COG2188	Transcriptional regulator
LK411_RS02515	COG2814	Major facilitator Superfamily
LK411_RS02520	COG2971	BadF BadG BcrA BcrD
LK411_RS02525	COG0134	indole-3-glycerol-phosphate synthase activity
LK411_RS02535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LK411_RS02545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LK411_RS02550	COG0107	imidazoleglycerol-phosphate synthase activity
LK411_RS02555	COG0483	inositol monophosphate 1-phosphatase activity
LK411_RS02560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LK411_RS02570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LK411_RS02590	COG1414	Transcriptional regulator
LK411_RS02595	COG2252	PERMEase
LK411_RS02605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LK411_RS02615	COG0402	S-adenosylhomocysteine deaminase activity
LK411_RS02625	COG3257	ureidoglycine aminohydrolase activity
LK411_RS02630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LK411_RS02635	COG1301	dicarboxylic acid transport
LK411_RS02645	COG1953	Uracil, thiamine, allantoin
LK411_RS02650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK411_RS02665	COG0131	Imidazoleglycerol-phosphate dehydratase
LK411_RS02670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK411_RS02675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LK411_RS02720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LK411_RS02770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LK411_RS02780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LK411_RS02790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LK411_RS02810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS02815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS02840	COG4585	Histidine kinase
LK411_RS02845	COG2197	response regulator
LK411_RS02850	COG0765	amino acid transport
LK411_RS02855	COG1126	abc transporter atp-binding protein
LK411_RS02860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK411_RS02870	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS02875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS02880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS02885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS02910	COG1846	Transcriptional regulator
LK411_RS02925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LK411_RS02930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LK411_RS02935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LK411_RS02940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LK411_RS02970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LK411_RS02990	COG0277	FAD linked oxidase domain protein
LK411_RS03005	COG0523	cobalamin synthesis protein
LK411_RS03020	COG0124	histidyl-tRNA synthetase
LK411_RS03035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK411_RS03045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK411_RS03060	COG0514	ATP-dependent DNA helicase (RecQ)
LK411_RS03070	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LK411_RS03075	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS03085	COG0632	four-way junction helicase activity
LK411_RS03090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LK411_RS03100	COG0217	transcriptional regulatory protein
LK411_RS03110	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LK411_RS03115	COG1946	Acyl-CoA thioesterase
LK411_RS03130	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LK411_RS03145	COG1051	belongs to the nudix hydrolase family
LK411_RS03150	COG0438	transferase activity, transferring glycosyl groups
LK411_RS03155	COG1560	Kdo2-lipid A biosynthetic process
LK411_RS03170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LK411_RS03205	COG0346	lactoylglutathione lyase activity
LK411_RS03265	COG0604	alcohol dehydrogenase
LK411_RS03265	COG3321	synthase
LK411_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS03315	COG1937	Protein conserved in bacteria
LK411_RS03325	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK411_RS03325	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK411_RS03340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK411_RS03345	COG3253	May function as heme-dependent peroxidase
LK411_RS03355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LK411_RS03370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LK411_RS03375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LK411_RS03395	COG0756	dUTP diphosphatase activity
LK411_RS03455	COG4770	biotin carboxylase activity
LK411_RS03460	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS03475	COG2267	carboxylic ester hydrolase activity
LK411_RS03480	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS03490	COG1960	acyl-CoA dehydrogenase activity
LK411_RS03495	COG1960	acyl-CoA dehydrogenase activity
LK411_RS03515	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS03520	COG1011	Hydrolase
LK411_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS03540	COG0183	Belongs to the thiolase family
LK411_RS03560	COG3590	peptidase
LK411_RS03565	COG2188	Transcriptional regulator
LK411_RS03585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK411_RS03590	COG0154	amidase activity
LK411_RS03640	COG2890	protein-(glutamine-N5) methyltransferase activity
LK411_RS03655	COG0123	including yeast histone deacetylase and acetoin utilization protein
LK411_RS03680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LK411_RS03725	COG1335	isochorismatase
LK411_RS03740	COG0450	alkyl hydroperoxide reductase
LK411_RS03755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK411_RS03770	COG1643	Atp-dependent helicase
LK411_RS03775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LK411_RS03785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LK411_RS03800	COG1960	acyl-CoA dehydrogenase activity
LK411_RS03805	COG1960	acyl-CoA dehydrogenase activity
LK411_RS03820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LK411_RS03825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LK411_RS03830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LK411_RS03840	COG1196	nuclear chromosome segregation
LK411_RS03855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK411_RS03860	COG1126	abc transporter atp-binding protein
LK411_RS03865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK411_RS03870	COG0765	amino acid transport
LK411_RS03875	COG0765	amino acid transport
LK411_RS03880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK411_RS03890	COG2137	regulation of response to DNA damage stimulus
LK411_RS03895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LK411_RS03900	COG2226	methyltransferase
LK411_RS03935	COG1842	Phage shock protein A
LK411_RS03940	COG1396	sequence-specific DNA binding
LK411_RS03945	COG1058	Belongs to the CinA family
LK411_RS03945	COG1546	Belongs to the CinA family
LK411_RS04000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LK411_RS04005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK411_RS04015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LK411_RS04135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LK411_RS04155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK411_RS04165	COG2409	Drug exporters of the RND superfamily
LK411_RS04190	COG1063	alcohol dehydrogenase
LK411_RS04195	COG1522	sequence-specific DNA binding
LK411_RS04200	COG0686	Belongs to the AlaDH PNT family
LK411_RS04210	COG1113	amino acid transport
LK411_RS04220	COG0584	glycerophosphoryl diester phosphodiesterase
LK411_RS04225	COG2267	carboxylic ester hydrolase activity
LK411_RS04240	COG1185	polyribonucleotide nucleotidyltransferase activity
LK411_RS04245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK411_RS04245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LK411_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS04255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LK411_RS04275	COG1309	transcriptional regulator
LK411_RS04280	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS04305	COG0372	Belongs to the citrate synthase family
LK411_RS04315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LK411_RS04325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LK411_RS04365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LK411_RS04370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LK411_RS04380	COG0481	GTPase activity
LK411_RS04380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LK411_RS04400	COG0673	inositol 2-dehydrogenase activity
LK411_RS04405	COG1609	Transcriptional regulator
LK411_RS04410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK411_RS04420	COG1116	anion transmembrane transporter activity
LK411_RS04455	COG0442	prolyl-tRNA aminoacylation
LK411_RS04460	COG3022	response to hydroperoxide
LK411_RS04475	COG1648	precorrin-2 dehydrogenase activity
LK411_RS04475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LK411_RS04505	COG0579	oxidoreductase
LK411_RS04520	COG2267	carboxylic ester hydrolase activity
LK411_RS04525	COG1492	cobalamin metabolic process
LK411_RS04540	COG0768	penicillin binding
LK411_RS04570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LK411_RS04575	COG0750	zinc metalloprotease
LK411_RS04585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LK411_RS04610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LK411_RS04615	COG5416	Lipopolysaccharide assembly protein A domain
LK411_RS04625	COG0575	Belongs to the CDS family
LK411_RS04630	COG0233	cytoplasmic translational termination
LK411_RS04635	COG0528	UMP kinase activity
LK411_RS04655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LK411_RS04660	COG0052	Belongs to the universal ribosomal protein uS2 family
LK411_RS04665	COG1115	amino acid carrier protein
LK411_RS04690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LK411_RS04695	COG1823	symporter activity
LK411_RS04705	COG0443	Heat shock 70 kDa protein
LK411_RS04715	COG2814	Major facilitator Superfamily
LK411_RS04720	COG0501	Belongs to the peptidase M48B family
LK411_RS04745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LK411_RS04755	COG0477	Major facilitator Superfamily
LK411_RS04760	COG2011	ABC-type metal ion transport system permease component
LK411_RS04765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LK411_RS04795	COG0792	nuclease activity
LK411_RS04805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LK411_RS04815	COG0335	large ribosomal subunit rRNA binding
LK411_RS04855	COG0336	Belongs to the RNA methyltransferase TrmD family
LK411_RS04860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LK411_RS04870	COG0228	four-way junction DNA binding
LK411_RS04875	COG0076	glutamate decarboxylase activity
LK411_RS04895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LK411_RS04900	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LK411_RS04960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS04975	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LK411_RS04980	COG0829	nickel cation binding
LK411_RS04985	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LK411_RS04990	COG0830	nickel cation binding
LK411_RS04995	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LK411_RS05000	COG0804	urea catabolic process
LK411_RS05005	COG0832	Belongs to the urease beta subunit family
LK411_RS05010	COG0831	urea catabolic process
LK411_RS05075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LK411_RS05085	COG0494	nUDIX hydrolase
LK411_RS05100	COG1196	nuclear chromosome segregation
LK411_RS05115	COG1609	Transcriptional regulator
LK411_RS05120	COG3766	membrane
LK411_RS05125	COG0754	glutathionylspermidine amidase activity
LK411_RS05135	COG1254	Belongs to the acylphosphatase family
LK411_RS05165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK411_RS05170	COG0571	ribonuclease III activity
LK411_RS05180	COG3599	regulation of cell shape
LK411_RS05185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LK411_RS05190	COG0742	ribosomal rna small subunit methyltransferase
LK411_RS05195	COG0477	Major facilitator Superfamily
LK411_RS05215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK411_RS05220	COG4257	antibiotic catabolic process
LK411_RS05225	COG0456	acetyltransferase
LK411_RS05235	COG1917	Cupin 2, conserved barrel domain protein
LK411_RS05270	COG0477	Major facilitator Superfamily
LK411_RS05275	COG2814	Major facilitator Superfamily
LK411_RS05280	COG0598	Magnesium transport protein CorA
LK411_RS05300	COG0740	serine-type endopeptidase activity
LK411_RS05305	COG0740	serine-type endopeptidase activity
LK411_RS05320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LK411_RS05325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LK411_RS05330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LK411_RS05340	COG1530	ribonuclease E activity
LK411_RS05345	COG0105	UTP biosynthetic process
LK411_RS05355	COG0285	dihydrofolate synthase activity
LK411_RS05360	COG0525	valine-tRNA ligase activity
LK411_RS05365	COG0488	(ABC) transporter
LK411_RS05375	COG0740	serine-type endopeptidase activity
LK411_RS05380	COG0740	serine-type endopeptidase activity
LK411_RS05385	COG0544	peptidyl-prolyl cis-trans isomerase activity
LK411_RS05410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK411_RS05425	COG3189	MarR family transcriptional regulator
LK411_RS05485	COG0515	serine threonine protein kinase
LK411_RS05490	COG3135	benzoate transporter
LK411_RS05495	COG1396	sequence-specific DNA binding
LK411_RS05505	COG3340	Belongs to the peptidase S51 family
LK411_RS05530	COG0477	Major facilitator Superfamily
LK411_RS05535	COG0640	Transcriptional regulator
LK411_RS05550	COG1024	Enoyl-CoA hydratase
LK411_RS05560	COG1396	sequence-specific DNA binding
LK411_RS05570	COG0531	amino acid
LK411_RS05585	COG2124	cytochrome p450
LK411_RS05600	COG2197	response regulator
LK411_RS05620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LK411_RS05650	COG0698	ribose 5-phosphate isomerase
LK411_RS05660	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LK411_RS05675	COG3012	SEC-C Motif Domain Protein
LK411_RS05680	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LK411_RS05695	COG5001	Diguanylate cyclase
LK411_RS05705	COG0366	Alpha amylase catalytic
LK411_RS05730	COG2902	Dehydrogenase
LK411_RS05765	COG0243	molybdopterin cofactor binding
LK411_RS05770	COG0303	'Molybdopterin
LK411_RS05775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK411_RS05775	COG2146	nitrite reductase [NAD(P)H] activity
LK411_RS05780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK411_RS05780	COG2146	nitrite reductase [NAD(P)H] activity
LK411_RS05850	COG1131	(ABC) transporter
LK411_RS05865	COG1012	belongs to the aldehyde dehydrogenase family
LK411_RS05865	COG2030	dehydratase
LK411_RS05870	COG1309	transcriptional regulator
LK411_RS05875	COG1024	Enoyl-CoA hydratase
LK411_RS05885	COG1024	Enoyl-CoA hydratase
LK411_RS05890	COG3396	Phenylacetate-CoA oxygenase
LK411_RS05895	COG3460	Phenylacetate-CoA oxygenase
LK411_RS05900	COG3396	Phenylacetate-CoA oxygenase
LK411_RS05905	COG2151	metal-sulfur cluster biosynthetic enzyme
LK411_RS05910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK411_RS05925	COG4565	transcriptional regulatory protein
LK411_RS05930	COG3290	protein histidine kinase activity
LK411_RS05935	COG2851	Citrate transporter
LK411_RS05955	COG1695	Transcriptional regulator
LK411_RS05960	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK411_RS05960	COG1902	pentaerythritol trinitrate reductase activity
LK411_RS05970	COG2259	Doxx family
LK411_RS05975	COG0300	oxidoreductase activity
LK411_RS05985	COG0433	COG0433 Predicted ATPase
LK411_RS05995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LK411_RS06030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK411_RS06050	COG3402	PFAM membrane-flanked domain
LK411_RS06055	COG1960	acyl-CoA dehydrogenase activity
LK411_RS06460	COG1376	ErfK ybiS ycfS ynhG family protein
LK411_RS06465	COG1252	NADH dehydrogenase
LK411_RS06470	COG0583	DNA-binding transcription factor activity
LK411_RS06485	COG1960	acyl-CoA dehydrogenase activity
LK411_RS06510	COG0439	Biotin carboxylase
LK411_RS06520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LK411_RS06525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LK411_RS06535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LK411_RS06660	COG1316	TRANSCRIPTIONal
LK411_RS06665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LK411_RS06670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LK411_RS06675	COG1234	tRNA 3'-trailer cleavage
LK411_RS06710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LK411_RS06715	COG1335	isochorismatase
LK411_RS06745	COG2351	hydroxyisourate hydrolase activity
LK411_RS06755	COG2233	PERMEase
LK411_RS06760	COG3622	Belongs to the hyi family
LK411_RS06765	COG2084	Dehydrogenase
LK411_RS06770	COG3960	tartronate-semialdehyde synthase activity
LK411_RS06775	COG1929	Belongs to the glycerate kinase type-1 family
LK411_RS06800	COG0477	Major facilitator Superfamily
LK411_RS06815	COG0366	Alpha amylase catalytic
LK411_RS06820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LK411_RS06825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK411_RS06835	COG0579	oxidoreductase
LK411_RS06850	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS06855	COG0657	acetylesterase activity
LK411_RS06880	COG0183	Belongs to the thiolase family
LK411_RS06900	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LK411_RS06935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LK411_RS06940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LK411_RS06945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LK411_RS06950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LK411_RS06965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK411_RS06970	COG0356	it plays a direct role in the translocation of protons across the membrane
LK411_RS06985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LK411_RS06990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LK411_RS07035	COG2890	protein-(glutamine-N5) methyltransferase activity
LK411_RS07040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LK411_RS07045	COG0254	rRNA binding
LK411_RS07060	COG0083	homoserine kinase activity
LK411_RS07065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LK411_RS07070	COG0460	homoserine dehydrogenase
LK411_RS07080	COG0018	arginyl-trna synthetase
LK411_RS07110	COG2199	diguanylate cyclase activity
LK411_RS07110	COG2203	Gaf domain
LK411_RS07125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LK411_RS07140	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS07160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK411_RS07180	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK411_RS07180	COG0567	Dehydrogenase, E1 component
LK411_RS07185	COG1309	transcriptional regulator
LK411_RS07200	COG0598	Magnesium transport protein CorA
LK411_RS07210	COG1609	Transcriptional regulator
LK411_RS07215	COG0366	Alpha amylase catalytic
LK411_RS07275	COG2239	Acts as a magnesium transporter
LK411_RS07290	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LK411_RS07300	COG0531	amino acid
LK411_RS07310	COG1482	cell wall glycoprotein biosynthetic process
LK411_RS07320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK411_RS07340	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LK411_RS07355	COG2226	methyltransferase
LK411_RS07355	COG1073	alpha beta
LK411_RS07360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LK411_RS07365	COG0297	glycogen (starch) synthase activity
LK411_RS07390	COG0789	Transcriptional regulator
LK411_RS07405	COG0463	Glycosyl transferase, family 2
LK411_RS07410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LK411_RS07415	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS07420	COG1611	Belongs to the LOG family
LK411_RS07425	COG1611	Belongs to the LOG family
LK411_RS07430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK411_RS07435	COG2239	Acts as a magnesium transporter
LK411_RS07455	COG3220	belongs to the UPF0276 family
LK411_RS07470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LK411_RS07485	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
LK411_RS07495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LK411_RS07500	COG0747	negative chemotaxis
LK411_RS07525	COG0667	Aldo Keto reductase
LK411_RS07535	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LK411_RS07540	COG3842	ATPase activity
LK411_RS07570	COG0738	Major facilitator superfamily
LK411_RS07575	COG1609	Transcriptional regulator
LK411_RS07585	COG1940	carbohydrate kinase activity
LK411_RS07590	COG0058	SHG alpha-glucan phosphorylase activity
LK411_RS07595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK411_RS07610	COG0477	Major facilitator Superfamily
LK411_RS07625	COG1960	acyl-CoA dehydrogenase activity
LK411_RS07635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK411_RS07640	COG1131	(ABC) transporter
LK411_RS07695	COG0437	4 iron, 4 sulfur cluster binding
LK411_RS07715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK411_RS07755	COG2249	NAD(P)H dehydrogenase (quinone) activity
LK411_RS07810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK411_RS07820	COG2832	Protein of unknown function (DUF454)
LK411_RS07840	COG0604	alcohol dehydrogenase
LK411_RS07845	COG3226	Transcriptional regulator
LK411_RS07865	COG2814	Major facilitator Superfamily
LK411_RS07920	COG0012	GTP binding
LK411_RS07930	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK411_RS07935	COG1129	ABC transporter
LK411_RS07940	COG1966	Carbon starvation protein
LK411_RS07955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LK411_RS07955	COG2169	Transcriptional regulator
LK411_RS07965	COG1322	Protein conserved in bacteria
LK411_RS07990	COG1570	exodeoxyribonuclease VII activity
LK411_RS08025	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LK411_RS08025	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LK411_RS08055	COG0456	acetyltransferase
LK411_RS08060	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LK411_RS08070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK411_RS08100	COG1116	anion transmembrane transporter activity
LK411_RS08105	COG4521	taurine ABC transporter
LK411_RS08110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK411_RS08130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LK411_RS08135	COG1331	Highly conserved protein containing a thioredoxin domain
LK411_RS08145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LK411_RS08155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LK411_RS08170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LK411_RS08190	COG2755	lipolytic protein G-D-S-L family
LK411_RS08280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LK411_RS08285	COG0668	transmembrane transport
LK411_RS08325	COG0148	phosphopyruvate hydratase activity
LK411_RS08345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK411_RS08350	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK411_RS08370	COG1034	ATP synthesis coupled electron transport
LK411_RS08375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LK411_RS08380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK411_RS08390	COG0713	ATP synthesis coupled electron transport
LK411_RS08420	COG1073	alpha beta
LK411_RS08440	COG3956	TIGRFAM MazG family protein
LK411_RS08510	COG1393	Belongs to the ArsC family
LK411_RS08535	COG2837	iron assimilation
LK411_RS08545	COG0542	response to heat
LK411_RS08555	COG5001	Diguanylate cyclase
LK411_RS08580	COG0193	aminoacyl-tRNA hydrolase activity
LK411_RS08590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LK411_RS08610	COG1280	lysine exporter protein (LysE YggA)
LK411_RS08625	COG0488	(ABC) transporter
LK411_RS08640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LK411_RS08645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LK411_RS08660	COG0084	hydrolase, TatD family'
LK411_RS08700	COG0477	Major facilitator Superfamily
LK411_RS08710	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LK411_RS08715	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LK411_RS08720	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LK411_RS08750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LK411_RS08765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LK411_RS08775	COG0596	Alpha beta hydrolase
LK411_RS08780	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK411_RS08790	COG5473	translation initiation factor activity
LK411_RS08815	COG3384	dioxygenase
LK411_RS08840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK411_RS08850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LK411_RS08855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LK411_RS08925	COG0521	Mo-molybdopterin cofactor biosynthetic process
LK411_RS08930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK411_RS08935	COG2205	protein histidine kinase activity
LK411_RS08940	COG0745	RESPONSE REGULATOR receiver
LK411_RS08950	COG2860	membrane
LK411_RS08960	COG0254	rRNA binding
LK411_RS08970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LK411_RS08980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LK411_RS09010	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LK411_RS09025	COG0640	Transcriptional regulator
LK411_RS09060	COG2814	Major facilitator Superfamily
LK411_RS09070	COG0045	succinate-CoA ligase (ADP-forming) activity
LK411_RS09105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK411_RS09110	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS09125	COG1960	acyl-CoA dehydrogenase activity
LK411_RS09135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK411_RS09145	COG1285	pathogenesis
LK411_RS09155	COG1116	anion transmembrane transporter activity
LK411_RS09160	COG0739	heme binding
LK411_RS09200	COG4424	Sulfotransferase
LK411_RS09215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LK411_RS09230	COG3119	arylsulfatase activity
LK411_RS09240	COG0166	Belongs to the GPI family
LK411_RS09250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK411_RS09255	COG2084	Dehydrogenase
LK411_RS09275	COG2364	Membrane
LK411_RS09280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK411_RS09310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK411_RS09315	COG1218	3'(2'),5'-bisphosphate nucleotidase
LK411_RS09350	COG0328	RNA-DNA hybrid ribonuclease activity
LK411_RS09360	COG1408	metallophosphoesterase
LK411_RS09390	COG2072	flavoprotein involved in K transport
LK411_RS09395	COG0656	L-ascorbic acid biosynthetic process
LK411_RS09425	COG0545	Peptidyl-prolyl cis-trans isomerase
LK411_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS09460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK411_RS09465	COG0259	pyridoxamine-phosphate oxidase activity
LK411_RS09475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LK411_RS09505	COG2814	Major facilitator Superfamily
LK411_RS09525	COG1846	Transcriptional regulator
LK411_RS09550	COG2814	Major facilitator Superfamily
LK411_RS09560	COG0477	Major facilitator Superfamily
LK411_RS09625	COG4941	Belongs to the sigma-70 factor family
LK411_RS09660	COG1061	Type III restriction enzyme res subunit
LK411_RS09735	COG2508	Transcriptional regulator
LK411_RS09755	COG1309	transcriptional regulator
LK411_RS09770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS09780	COG2188	Transcriptional regulator
LK411_RS09805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK411_RS09810	COG1263	PTS System
LK411_RS09815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LK411_RS09830	COG0384	phenazine biosynthesis protein PhzF
LK411_RS09835	COG1126	abc transporter atp-binding protein
LK411_RS09840	COG0765	amino acid transport
LK411_RS09845	COG0640	Transcriptional regulator
LK411_RS09890	COG2376	Dihydroxyacetone kinase
LK411_RS09895	COG1073	alpha beta
LK411_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS09910	COG2508	Transcriptional regulator
LK411_RS09915	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS09940	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS09960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK411_RS09985	COG2186	Transcriptional regulator
LK411_RS09995	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS10000	COG4948	Mandelate Racemase Muconate Lactonizing
LK411_RS10010	COG3254	rhamnose metabolic process
LK411_RS10025	COG3304	Inner membrane component domain
LK411_RS10090	COG0081	regulation of translation
LK411_RS10095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LK411_RS10105	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LK411_RS10115	COG2030	dehydratase
LK411_RS10120	COG2030	dehydratase
LK411_RS10145	COG1666	GTP binding
LK411_RS10155	COG0142	geranyltranstransferase activity
LK411_RS10160	COG2226	methyltransferase
LK411_RS10165	COG0438	transferase activity, transferring glycosyl groups
LK411_RS10175	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LK411_RS10185	COG3180	Ammonia monooxygenase
LK411_RS10190	COG3268	Saccharopine dehydrogenase
LK411_RS10195	COG1937	Protein conserved in bacteria
LK411_RS10205	COG2409	Drug exporters of the RND superfamily
LK411_RS10215	COG0154	amidase activity
LK411_RS10235	COG4948	Mandelate Racemase Muconate Lactonizing
LK411_RS10315	COG3629	intracellular signal transduction
LK411_RS10345	COG1960	acyl-CoA dehydrogenase activity
LK411_RS10360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LK411_RS10375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LK411_RS10385	COG0785	Cytochrome C biogenesis protein
LK411_RS10390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK411_RS10395	COG0406	alpha-ribazole phosphatase activity
LK411_RS10400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LK411_RS10405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK411_RS10410	COG2272	Belongs to the type-B carboxylesterase lipase family
LK411_RS10415	COG3540	Alkaline phosphatase
LK411_RS10420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK411_RS10440	COG2011	ABC-type metal ion transport system permease component
LK411_RS10445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LK411_RS10455	COG2409	Drug exporters of the RND superfamily
LK411_RS10460	COG2954	triphosphatase activity
LK411_RS10465	COG2608	mercury ion transmembrane transporter activity
LK411_RS10495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LK411_RS10495	COG1648	precorrin-2 dehydrogenase activity
LK411_RS10500	COG0181	hydroxymethylbilane synthase activity
LK411_RS10505	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LK411_RS10545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LK411_RS10585	COG5002	protein histidine kinase activity
LK411_RS10595	COG0588	phosphoglycerate mutase activity
LK411_RS10615	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK411_RS10630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS10635	COG2814	Major facilitator Superfamily
LK411_RS10640	COG0583	DNA-binding transcription factor activity
LK411_RS10645	COG4106	trans-aconitate 2-methyltransferase activity
LK411_RS10650	COG1119	ATPase activity
LK411_RS10675	COG2318	DinB family
LK411_RS10685	COG0667	Aldo Keto reductase
LK411_RS10710	COG0477	Major facilitator Superfamily
LK411_RS10735	COG0477	Major facilitator Superfamily
LK411_RS10745	COG0438	transferase activity, transferring glycosyl groups
LK411_RS10750	COG0596	Alpha beta hydrolase
LK411_RS10795	COG1116	anion transmembrane transporter activity
LK411_RS10800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LK411_RS10805	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LK411_RS10820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK411_RS10825	COG0215	cysteine-tRNA ligase activity
LK411_RS10880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LK411_RS10885	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LK411_RS10895	COG0288	reversible hydration of carbon dioxide
LK411_RS10900	COG1194	a g-specific adenine glycosylase
LK411_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS10910	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LK411_RS10925	COG4221	oxidoreductase activity
LK411_RS10930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK411_RS10945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LK411_RS10975	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LK411_RS10985	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LK411_RS10990	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LK411_RS10995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LK411_RS11020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LK411_RS11025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LK411_RS11030	COG0302	gtp cyclohydrolase
LK411_RS11035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK411_RS11060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LK411_RS11065	COG0037	tRNA processing
LK411_RS11075	COG2027	D-alanyl-D-alanine carboxypeptidase
LK411_RS11105	COG0442	prolyl-tRNA aminoacylation
LK411_RS11130	COG3226	Transcriptional regulator
LK411_RS11140	COG1690	Belongs to the RtcB family
LK411_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS11210	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LK411_RS11215	COG2814	Major facilitator Superfamily
LK411_RS11230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LK411_RS11240	COG4129	membrane
LK411_RS11270	COG0586	Pfam SNARE associated Golgi protein
LK411_RS11275	COG0586	Pfam SNARE associated Golgi protein
LK411_RS11280	COG0488	(ABC) transporter
LK411_RS11330	COG2149	membrane
LK411_RS11350	COG2267	carboxylic ester hydrolase activity
LK411_RS11385	COG0789	Transcriptional regulator
LK411_RS11390	COG0484	heat shock protein binding
LK411_RS11395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LK411_RS11400	COG0443	Heat shock 70 kDa protein
LK411_RS11425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LK411_RS11485	COG0708	Exodeoxyribonuclease III
LK411_RS11500	COG1309	transcriptional regulator
LK411_RS11520	COG2181	nitrate reductase activity
LK411_RS11520	COG0247	lactate metabolic process
LK411_RS11580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LK411_RS11595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LK411_RS11600	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LK411_RS11600	COG2066	Belongs to the glutaminase family
LK411_RS11610	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS11620	COG1115	amino acid carrier protein
LK411_RS11630	COG0477	Major facilitator Superfamily
LK411_RS11650	COG1960	acyl-CoA dehydrogenase activity
LK411_RS11675	COG1832	CoA-binding protein
LK411_RS11680	COG0183	Belongs to the thiolase family
LK411_RS11685	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS11690	COG2030	dehydratase
LK411_RS11700	COG1309	transcriptional regulator
LK411_RS11705	COG1472	Belongs to the glycosyl hydrolase 3 family
LK411_RS11725	COG4981	capsule polysaccharide biosynthetic process
LK411_RS11785	COG0492	ferredoxin-NADP+ reductase activity
LK411_RS11815	COG1595	DNA-templated transcription, initiation
LK411_RS11825	COG0577	efflux transmembrane transporter activity
LK411_RS11830	COG0577	efflux transmembrane transporter activity
LK411_RS11830	COG1136	(ABC) transporter
LK411_RS11855	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LK411_RS11855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK411_RS11860	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LK411_RS11895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LK411_RS11905	COG2409	Drug exporters of the RND superfamily
LK411_RS11935	COG1309	transcriptional regulator
LK411_RS11955	COG1252	NADH dehydrogenase
LK411_RS12015	COG3590	peptidase
LK411_RS12030	COG1024	Enoyl-CoA hydratase
LK411_RS12030	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK411_RS12035	COG0183	Belongs to the thiolase family
LK411_RS12040	COG1309	transcriptional regulator
LK411_RS12070	COG1404	Belongs to the peptidase S8 family
LK411_RS12110	COG1674	ftsk spoiiie
LK411_RS12120	COG0464	growth
LK411_RS12145	COG0488	(ABC) transporter
LK411_RS12160	COG3214	Protein conserved in bacteria
LK411_RS12165	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LK411_RS12175	COG1760	l-serine dehydratase
LK411_RS12180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LK411_RS12185	COG1396	sequence-specific DNA binding
LK411_RS12225	COG1309	transcriptional regulator
LK411_RS12240	COG1846	Transcriptional regulator
LK411_RS12250	COG3191	aminopeptidase activity
LK411_RS12280	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LK411_RS12285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LK411_RS12295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK411_RS12310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK411_RS12310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK411_RS12310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK411_RS12320	COG1349	DNA-binding transcription factor activity
LK411_RS12325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK411_RS12335	COG2353	YceI-like domain
LK411_RS12355	COG1956	GAF domain-containing protein
LK411_RS12375	COG0277	FAD linked oxidase domain protein
LK411_RS12380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK411_RS12385	COG3321	synthase
LK411_RS12385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK411_RS12385	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LK411_RS12395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS12405	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LK411_RS12410	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LK411_RS12440	COG0156	8-amino-7-oxononanoate synthase activity
LK411_RS12455	COG2203	Gaf domain
LK411_RS12455	COG2199	diguanylate cyclase activity
LK411_RS12465	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LK411_RS12470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LK411_RS12475	COG0671	phosphoesterase, PA-phosphatase related
LK411_RS12480	COG1216	Glycosyl transferase, family 2
LK411_RS12490	COG2385	sporulation resulting in formation of a cellular spore
LK411_RS12495	COG0561	phosphatase activity
LK411_RS12505	COG2146	nitrite reductase [NAD(P)H] activity
LK411_RS12505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LK411_RS12525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LK411_RS12540	COG0813	purine-nucleoside phosphorylase activity
LK411_RS12585	COG3226	Transcriptional regulator
LK411_RS12595	COG2252	PERMEase
LK411_RS12635	COG0425	Belongs to the sulfur carrier protein TusA family
LK411_RS12635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LK411_RS12675	COG2119	membrane
LK411_RS12745	COG1216	Glycosyl transferase, family 2
LK411_RS12760	COG2755	lipolytic protein G-D-S-L family
LK411_RS12765	COG1012	belongs to the aldehyde dehydrogenase family
LK411_RS12775	COG2501	S4 domain
LK411_RS12800	COG0070	glutamate synthase
LK411_RS12800	COG0067	glutamate synthase
LK411_RS12800	COG0069	glutamate synthase activity
LK411_RS12805	COG0390	transport system, permease component
LK411_RS12810	COG0667	Aldo Keto reductase
LK411_RS12820	COG1131	(ABC) transporter
LK411_RS12825	COG3559	Exporter of polyketide antibiotics
LK411_RS12840	COG2205	protein histidine kinase activity
LK411_RS12845	COG0745	RESPONSE REGULATOR receiver
LK411_RS12860	COG2205	protein histidine kinase activity
LK411_RS12865	COG0745	RESPONSE REGULATOR receiver
LK411_RS12890	COG1376	ErfK ybiS ycfS ynhG family protein
LK411_RS12895	COG0778	Nitroreductase
LK411_RS12915	COG0657	acetylesterase activity
LK411_RS12925	COG3336	cytochrome c oxidase
LK411_RS12950	COG1073	alpha beta
LK411_RS12990	COG2957	Belongs to the agmatine deiminase family
LK411_RS13010	COG1012	belongs to the aldehyde dehydrogenase family
LK411_RS13070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LK411_RS13080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LK411_RS13105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LK411_RS13135	COG0438	transferase activity, transferring glycosyl groups
LK411_RS13180	COG0657	acetylesterase activity
LK411_RS13220	COG1716	ATPase activity
LK411_RS13225	COG1716	ATPase activity
LK411_RS13240	COG0768	penicillin binding
LK411_RS13245	COG0515	serine threonine protein kinase
LK411_RS13250	COG2815	serine threonine protein kinase
LK411_RS13250	COG0515	serine threonine protein kinase
LK411_RS13275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LK411_RS13305	COG1253	flavin adenine dinucleotide binding
LK411_RS13325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LK411_RS13330	COG0187	DNA topoisomerase II activity
LK411_RS13340	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LK411_RS13350	COG0477	Major facilitator Superfamily
LK411_RS13360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LK411_RS13365	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LK411_RS13370	COG0592	DNA-directed DNA polymerase activity
LK411_RS13380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LK411_RS13390	COG0594	ribonuclease P activity
LK411_RS13395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LK411_RS13400	COG0706	membrane insertase activity
LK411_RS13410	COG0357	Ribosomal RNA small subunit methyltransferase G
LK411_RS13415	COG1192	Involved in chromosome partitioning
LK411_RS13430	COG0860	N-Acetylmuramoyl-L-alanine amidase
LK411_RS13430	COG3409	Peptidoglycan-binding domain 1 protein
LK411_RS13450	COG1595	DNA-templated transcription, initiation
LK411_RS13455	COG1012	belongs to the aldehyde dehydrogenase family
LK411_RS13460	COG0519	Catalyzes the synthesis of GMP from XMP
LK411_RS13485	COG0617	tRNA 3'-terminal CCA addition
LK411_RS13525	COG0495	leucyl-tRNA aminoacylation
LK411_RS13550	COG4122	O-methyltransferase activity
LK411_RS13560	COG4221	oxidoreductase activity
LK411_RS13565	COG2814	Major facilitator Superfamily
LK411_RS13595	COG1131	(ABC) transporter
LK411_RS13605	COG2197	response regulator
LK411_RS13620	COG1131	(ABC) transporter
LK411_RS13660	COG1297	OPT oligopeptide transporter protein
LK411_RS13675	COG1358	cellular component organization or biogenesis
LK411_RS13735	COG1260	myo-inositol-1-phosphate synthase
LK411_RS13750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK411_RS13775	COG1024	Enoyl-CoA hydratase
LK411_RS13785	COG2197	response regulator
LK411_RS13790	COG4585	Histidine kinase
LK411_RS13810	COG1024	Enoyl-CoA hydratase
LK411_RS13810	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK411_RS13815	COG0183	Belongs to the thiolase family
LK411_RS13890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LK411_RS13900	COG0360	Binds together with S18 to 16S ribosomal RNA
LK411_RS13990	COG0789	Transcriptional regulator
LK411_RS13995	COG0640	Transcriptional regulator
LK411_RS14000	COG0798	PFAM Bile acid sodium symporter
LK411_RS14005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK411_RS14010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK411_RS14015	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK411_RS14090	COG1937	Protein conserved in bacteria
LK411_RS14115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LK411_RS14120	COG0745	RESPONSE REGULATOR receiver
LK411_RS14125	COG2205	protein histidine kinase activity
LK411_RS14130	COG2132	Multicopper oxidase
LK411_RS14135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK411_RS14140	COG0785	Cytochrome C biogenesis protein
LK411_RS14165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK411_RS14170	COG1376	ErfK ybiS ycfS ynhG family protein
LK411_RS14195	COG3883	PFAM NLP P60 protein
LK411_RS14195	COG0791	NLP P60 protein
LK411_RS14230	COG3973	AAA domain
LK411_RS14245	COG1174	glycine betaine transport
LK411_RS14290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LK411_RS14345	COG1268	BioY protein
LK411_RS14350	COG1122	ATPase activity
LK411_RS14365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LK411_RS14370	COG4221	oxidoreductase activity
LK411_RS14380	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS14390	COG1309	transcriptional regulator
LK411_RS14405	COG1473	amidohydrolase
LK411_RS14410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LK411_RS14415	COG0006	proline dipeptidase activity
LK411_RS14420	COG1012	belongs to the aldehyde dehydrogenase family
LK411_RS14435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LK411_RS14445	COG1476	TRANSCRIPTIONal
LK411_RS14480	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS14485	COG1216	Glycosyl transferase, family 2
LK411_RS14525	COG0183	Belongs to the thiolase family
LK411_RS14775	COG0640	Transcriptional regulator
LK411_RS14785	COG0385	Bile acid
LK411_RS14805	COG2030	dehydratase
LK411_RS14850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK411_RS14920	COG0739	heme binding
LK411_RS14970	COG0287	Prephenate dehydrogenase
LK411_RS14980	COG0590	tRNA wobble adenosine to inosine editing
LK411_RS15010	COG0343	queuine tRNA-ribosyltransferase activity
LK411_RS15025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK411_RS15035	COG2318	DinB family
LK411_RS15040	COG1793	dna ligase
LK411_RS15070	COG0640	Transcriptional regulator
LK411_RS15085	COG0583	DNA-binding transcription factor activity
LK411_RS15100	COG0596	Alpha beta hydrolase
LK411_RS15125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK411_RS15150	COG4214	carbohydrate transport
LK411_RS15160	COG4213	ABC transporter substrate-binding protein
LK411_RS15165	COG1940	carbohydrate kinase activity
LK411_RS15180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LK411_RS15195	COG0564	pseudouridine synthase activity
LK411_RS15200	COG0860	N-Acetylmuramoyl-L-alanine amidase
LK411_RS15230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LK411_RS15250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LK411_RS15260	COG0697	spore germination
LK411_RS15265	COG0583	DNA-binding transcription factor activity
LK411_RS15270	COG2807	transmembrane transport
LK411_RS15290	COG1017	nitric oxide dioxygenase activity
LK411_RS15290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK411_RS15295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK411_RS15300	COG0697	spore germination
LK411_RS15310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK411_RS15325	COG3251	PFAM MbtH domain protein
LK411_RS15365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LK411_RS15380	COG1309	transcriptional regulator
LK411_RS15400	COG0135	phosphoribosylanthranilate isomerase activity
LK411_RS15410	COG0768	penicillin binding
LK411_RS15420	COG0583	DNA-binding transcription factor activity
LK411_RS15430	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS15455	COG1764	response to oxidative stress
LK411_RS15460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LK411_RS15465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LK411_RS15480	COG1408	metallophosphoesterase
LK411_RS15490	COG4974	Belongs to the 'phage' integrase family
LK411_RS15575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LK411_RS15620	COG2814	Major facilitator Superfamily
LK411_RS15635	COG1024	Enoyl-CoA hydratase
LK411_RS15650	COG1960	acyl-CoA dehydrogenase activity
LK411_RS15660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LK411_RS15690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK411_RS15695	COG2828	Protein conserved in bacteria
LK411_RS15720	COG0494	nUDIX hydrolase
LK411_RS15730	COG2226	methyltransferase
LK411_RS15730	COG0596	Alpha beta hydrolase
LK411_RS15730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LK411_RS15740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LK411_RS15745	COG0477	Major facilitator Superfamily
LK411_RS15755	COG3663	DNA glycosylase
LK411_RS15780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK411_RS15785	COG4166	transmembrane transport
LK411_RS15790	COG0601	transmembrane transport
LK411_RS15795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK411_RS15835	COG0640	Transcriptional regulator
LK411_RS15845	COG1695	Transcriptional regulator
LK411_RS15940	COG1132	(ABC) transporter
LK411_RS15955	COG1111	helicase
LK411_RS15955	COG1205	dead DEAH box helicase
LK411_RS15960	COG1278	Cold shock
LK411_RS15970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LK411_RS15970	COG1754	DNA topoisomerase type I activity
LK411_RS15980	COG0470	DNA polymerase III
LK411_RS15990	COG2072	flavoprotein involved in K transport
LK411_RS15995	COG2508	Transcriptional regulator
LK411_RS16075	COG1960	acyl-CoA dehydrogenase activity
LK411_RS16090	COG2030	dehydratase
LK411_RS16105	COG4638	Rieske (2fe-2S)
LK411_RS16110	COG1053	succinate dehydrogenase
LK411_RS16120	COG3573	Dehydrogenase
LK411_RS16125	COG1960	acyl-CoA dehydrogenase activity
LK411_RS16130	COG2267	carboxylic ester hydrolase activity
LK411_RS16135	COG0346	lactoylglutathione lyase activity
LK411_RS16140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LK411_RS16160	COG1960	acyl-CoA dehydrogenase activity
LK411_RS16165	COG1960	acyl-CoA dehydrogenase activity
LK411_RS16170	COG1960	acyl-CoA dehydrogenase activity
LK411_RS16175	COG1024	Enoyl-CoA hydratase
LK411_RS16180	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS16185	COG1960	acyl-CoA dehydrogenase activity
LK411_RS16190	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS16195	COG1309	transcriptional regulator
LK411_RS16200	COG0183	Belongs to the thiolase family
LK411_RS16230	COG1024	Enoyl-CoA hydratase
LK411_RS16235	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS16240	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS16245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LK411_RS16250	COG0183	Belongs to the thiolase family
LK411_RS16255	COG2124	cytochrome p450
LK411_RS16280	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS16290	COG2070	2-Nitropropane dioxygenase
LK411_RS16305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS16310	COG1012	belongs to the aldehyde dehydrogenase family
LK411_RS16335	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS16340	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LK411_RS16345	COG1960	acyl-CoA dehydrogenase activity
LK411_RS16350	COG1960	acyl-CoA dehydrogenase activity
LK411_RS16370	COG1414	Transcriptional regulator
LK411_RS16400	COG3971	2-oxopent-4-enoate hydratase activity
LK411_RS16405	COG1960	acyl-CoA dehydrogenase activity
LK411_RS16440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LK411_RS16445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LK411_RS16450	COG1309	transcriptional regulator
LK411_RS16455	COG1088	dTDP-glucose 4,6-dehydratase activity
LK411_RS16475	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LK411_RS16485	COG4941	Belongs to the sigma-70 factor family
LK411_RS16505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK411_RS16520	COG0657	acetylesterase activity
LK411_RS16550	COG1132	(ABC) transporter
LK411_RS16565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS16575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LK411_RS16590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK411_RS16595	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK411_RS16600	COG1120	ATPase activity
LK411_RS16610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK411_RS16625	COG0352	thiamine-phosphate diphosphorylase activity
LK411_RS16630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK411_RS16630	COG2022	thiamine diphosphate biosynthetic process
LK411_RS16640	COG2022	thiamine diphosphate biosynthetic process
LK411_RS16645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LK411_RS16650	COG1309	transcriptional regulator
LK411_RS16655	COG0477	Major facilitator Superfamily
LK411_RS16680	COG0351	phosphomethylpyrimidine kinase
LK411_RS16685	COG0351	phosphomethylpyrimidine kinase
LK411_RS16690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LK411_RS16700	COG4555	ABC transporter
LK411_RS16740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LK411_RS16745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK411_RS16750	COG1120	ATPase activity
LK411_RS16780	COG1320	monovalent cation:proton antiporter activity
LK411_RS16795	COG0651	ATP synthesis coupled electron transport
LK411_RS16800	COG1006	Multisubunit Na H antiporter MnhC subunit
LK411_RS16805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LK411_RS16805	COG2111	Na H antiporter
LK411_RS16820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK411_RS16830	COG0688	phosphatidylethanolamine metabolic process
LK411_RS16890	COG0326	Molecular chaperone. Has ATPase activity
LK411_RS16915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS16940	COG1535	isochorismatase
LK411_RS16940	COG3433	isochorismatase activity
LK411_RS16950	COG4607	ABC-type enterochelin transport system periplasmic component
LK411_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS16970	COG1021	2,3-dihydroxybenzoate-AMP ligase
LK411_RS16975	COG1535	isochorismatase
LK411_RS16975	COG3433	isochorismatase activity
LK411_RS16985	COG1132	(ABC) transporter
LK411_RS16990	COG1132	(ABC) transporter
LK411_RS17000	COG2326	polyphosphate kinase activity
LK411_RS17025	COG0477	Major facilitator Superfamily
LK411_RS17030	COG2259	Doxx family
LK411_RS17045	COG1505	serine-type exopeptidase activity
LK411_RS17060	COG5285	phytanoyl-CoA dioxygenase
LK411_RS17075	COG2224	Isocitrate lyase
LK411_RS17085	COG0492	ferredoxin-NADP+ reductase activity
LK411_RS17095	COG0583	DNA-binding transcription factor activity
LK411_RS17100	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS17110	COG2326	polyphosphate kinase activity
LK411_RS17115	COG2733	membrane
LK411_RS17140	COG0788	formyltetrahydrofolate deformylase activity
LK411_RS17145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LK411_RS17180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LK411_RS17190	COG1305	Transglutaminase-like
LK411_RS17200	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LK411_RS17240	COG1024	Enoyl-CoA hydratase
LK411_RS17285	COG0745	RESPONSE REGULATOR receiver
LK411_RS17290	COG5002	protein histidine kinase activity
LK411_RS17295	COG1088	dTDP-glucose 4,6-dehydratase activity
LK411_RS17315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK411_RS17330	COG0745	RESPONSE REGULATOR receiver
LK411_RS17335	COG2205	protein histidine kinase activity
LK411_RS17365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LK411_RS17370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LK411_RS17385	COG0477	Major facilitator Superfamily
LK411_RS17395	COG0386	Belongs to the glutathione peroxidase family
LK411_RS17415	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LK411_RS17420	COG0047	phosphoribosylformylglycinamidine synthase activity
LK411_RS17425	COG1362	aminopeptidase activity
LK411_RS17430	COG1063	alcohol dehydrogenase
LK411_RS17435	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS17440	COG0477	Major facilitator Superfamily
LK411_RS17455	COG1113	amino acid transport
LK411_RS17460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LK411_RS17470	COG3938	Belongs to the proline racemase family
LK411_RS17485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK411_RS17490	COG4172	Belongs to the ABC transporter superfamily
LK411_RS17495	COG0747	negative chemotaxis
LK411_RS17500	COG4565	transcriptional regulatory protein
LK411_RS17510	COG1301	dicarboxylic acid transport
LK411_RS17515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK411_RS17550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LK411_RS17555	COG1113	amino acid transport
LK411_RS17570	COG5343	regulation of RNA biosynthetic process
LK411_RS17590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LK411_RS17640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LK411_RS17655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LK411_RS17660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LK411_RS17675	COG1271	oxidase subunit
LK411_RS17680	COG1294	oxidase, subunit
LK411_RS17685	COG4988	ABC transporter
LK411_RS17690	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LK411_RS17705	COG4044	May play a role in the intracellular transport of hydrophobic ligands
LK411_RS17730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK411_RS17740	COG0477	Major facilitator Superfamily
LK411_RS17750	COG3145	DNA-N1-methyladenine dioxygenase activity
LK411_RS17765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LK411_RS17780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LK411_RS17790	COG2897	thiosulfate sulfurtransferase activity
LK411_RS17800	COG0745	RESPONSE REGULATOR receiver
LK411_RS17805	COG0456	acetyltransferase
LK411_RS17825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LK411_RS17850	COG2197	response regulator
LK411_RS17865	COG1131	(ABC) transporter
LK411_RS17875	COG1175	transmembrane transport
LK411_RS17885	COG1653	transport
LK411_RS17890	COG3842	ATPase activity
LK411_RS17895	COG0477	Major facilitator Superfamily
LK411_RS17905	COG0438	transferase activity, transferring glycosyl groups
LK411_RS17920	COG2199	diguanylate cyclase activity
LK411_RS17935	COG0640	Transcriptional regulator
LK411_RS17945	COG1595	DNA-templated transcription, initiation
LK411_RS17980	COG0657	acetylesterase activity
LK411_RS17995	COG2072	flavoprotein involved in K transport
LK411_RS18005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LK411_RS18040	COG1131	(ABC) transporter
LK411_RS18060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LK411_RS18065	COG0049	tRNA binding
LK411_RS18070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LK411_RS18075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LK411_RS18155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK411_RS18180	COG0051	transcription antitermination factor activity, RNA binding
LK411_RS18190	COG0088	Forms part of the polypeptide exit tunnel
LK411_RS18195	COG0089	rRNA binding
LK411_RS18200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LK411_RS18205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LK411_RS18215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LK411_RS18220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LK411_RS18225	COG0255	Belongs to the universal ribosomal protein uL29 family
LK411_RS18230	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LK411_RS18245	COG0513	Belongs to the DEAD box helicase family
LK411_RS18265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LK411_RS18270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LK411_RS18275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LK411_RS18315	COG1131	(ABC) transporter
LK411_RS18325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LK411_RS18330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LK411_RS18335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LK411_RS18350	COG0200	Binds to the 23S rRNA
LK411_RS18360	COG0563	adenylate kinase activity
LK411_RS18370	COG0789	Transcriptional regulator
LK411_RS18385	COG2002	toxin-antitoxin pair type II binding
LK411_RS18395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LK411_RS18400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LK411_RS18410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LK411_RS18415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LK411_RS18420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LK411_RS18425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LK411_RS18430	COG0202	RNA polymerase activity
LK411_RS18435	COG0203	ribosomal protein L17
LK411_RS18455	COG0101	tRNA pseudouridine synthase activity
LK411_RS18525	COG1404	Belongs to the peptidase S8 family
LK411_RS18535	COG1674	ftsk spoiiie
LK411_RS18560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LK411_RS18570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK411_RS18575	COG0546	phosphoglycolate phosphatase activity
LK411_RS18605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LK411_RS18620	COG2154	pterin-4-alpha-carbinolamine dehydratase
LK411_RS18645	COG0456	acetyltransferase
LK411_RS18650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LK411_RS18700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LK411_RS18705	COG0459	protein refolding
LK411_RS18740	COG0516	GMP reductase activity
LK411_RS18760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LK411_RS18760	COG0519	Catalyzes the synthesis of GMP from XMP
LK411_RS18765	COG0702	epimerase
LK411_RS18785	COG2197	response regulator
LK411_RS18790	COG0515	serine threonine protein kinase
LK411_RS18790	COG2815	serine threonine protein kinase
LK411_RS18800	COG0833	amino acid
LK411_RS18845	COG0587	DNA-directed DNA polymerase activity
LK411_RS18865	COG1872	DUF167
LK411_RS18880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LK411_RS18890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LK411_RS18910	COG2814	Major facilitator Superfamily
LK411_RS18925	COG0708	Exodeoxyribonuclease III
LK411_RS18930	COG0180	Tryptophanyl-tRNA synthetase
LK411_RS18935	COG1295	ribonuclease BN
LK411_RS18945	COG1686	Belongs to the peptidase S11 family
LK411_RS18990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LK411_RS19005	COG2009	succinate dehydrogenase
LK411_RS19020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK411_RS19030	COG2197	response regulator
LK411_RS19065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK411_RS19080	COG1473	amidohydrolase
LK411_RS19080	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LK411_RS19085	COG1473	amidohydrolase
LK411_RS19085	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LK411_RS19090	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS19115	COG1595	DNA-templated transcription, initiation
LK411_RS19135	COG1349	DNA-binding transcription factor activity
LK411_RS19150	COG0205	6-phosphofructokinase activity
LK411_RS19155	COG2390	Transcriptional regulator
LK411_RS19170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LK411_RS19175	COG0148	phosphopyruvate hydratase activity
LK411_RS19180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK411_RS19185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LK411_RS19190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LK411_RS19200	COG0477	Major facilitator Superfamily
LK411_RS19220	COG4977	sequence-specific DNA binding
LK411_RS19225	COG3360	Dodecin
LK411_RS19240	COG1201	RNA secondary structure unwinding
LK411_RS19245	COG2272	Belongs to the type-B carboxylesterase lipase family
LK411_RS19255	COG0431	NADPH-dependent FMN reductase
LK411_RS19260	COG1396	sequence-specific DNA binding
LK411_RS19280	COG4770	biotin carboxylase activity
LK411_RS19325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK411_RS19330	COG0424	maF-like protein
LK411_RS19340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK411_RS19345	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LK411_RS19345	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LK411_RS19355	COG0745	RESPONSE REGULATOR receiver
LK411_RS19365	COG2205	protein histidine kinase activity
LK411_RS19390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK411_RS19410	COG1316	TRANSCRIPTIONal
LK411_RS19425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LK411_RS19430	COG2755	lipolytic protein G-D-S-L family
LK411_RS19435	COG4122	O-methyltransferase activity
LK411_RS19440	COG1595	DNA-templated transcription, initiation
LK411_RS19445	COG5662	AntiSigma factor
LK411_RS19450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK411_RS19455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LK411_RS19480	COG0745	RESPONSE REGULATOR receiver
LK411_RS19485	COG5002	protein histidine kinase activity
LK411_RS19490	COG5401	PFAM Sporulation and spore germination
LK411_RS19505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LK411_RS19510	COG0653	protein targeting
LK411_RS19580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK411_RS19585	COG1162	GTPase activity
LK411_RS19590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LK411_RS19605	COG2135	peptidase activity
LK411_RS19620	COG1012	belongs to the aldehyde dehydrogenase family
LK411_RS19640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LK411_RS19650	COG2337	Toxic component of a toxin-antitoxin (TA) module
LK411_RS19660	COG1595	DNA-templated transcription, initiation
LK411_RS19680	COG1597	lipid kinase activity
LK411_RS19690	COG0406	alpha-ribazole phosphatase activity
LK411_RS19695	COG1192	Involved in chromosome partitioning
LK411_RS19705	COG3739	integral membrane protein
LK411_RS19720	COG0513	Belongs to the DEAD box helicase family
LK411_RS19730	COG1309	transcriptional regulator
LK411_RS19735	COG0596	Alpha beta hydrolase
LK411_RS19780	COG0596	Alpha beta hydrolase
LK411_RS19800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK411_RS19805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK411_RS19840	COG1960	acyl-CoA dehydrogenase activity
LK411_RS19855	COG1846	Transcriptional regulator
LK411_RS19875	COG3480	Lon protease (S16) C-terminal proteolytic domain
LK411_RS19885	COG1615	UPF0182 protein
LK411_RS19895	COG0110	maltose O-acetyltransferase activity
LK411_RS19900	COG0730	response to heat
LK411_RS19910	COG2814	Major facilitator Superfamily
LK411_RS19915	COG1388	LysM domain
LK411_RS19920	COG2409	Drug exporters of the RND superfamily
LK411_RS19925	COG2197	response regulator
LK411_RS19935	COG1960	acyl-CoA dehydrogenase activity
LK411_RS19940	COG1960	acyl-CoA dehydrogenase activity
LK411_RS19945	COG0483	inositol monophosphate 1-phosphatase activity
LK411_RS19960	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LK411_RS19965	COG0668	transmembrane transport
LK411_RS19975	COG2884	Cell division ATP-binding protein ftsE
LK411_RS19980	COG2177	Part of the ABC transporter FtsEX involved in
LK411_RS19985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LK411_RS20020	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LK411_RS20050	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LK411_RS20055	COG0800	Aldolase
LK411_RS20060	COG2610	gluconate transmembrane transporter activity
LK411_RS20065	COG0033	Phosphoglucomutase
LK411_RS20085	COG4399	Belongs to the UPF0754 family
LK411_RS20150	COG0640	Transcriptional regulator
LK411_RS20155	COG1733	regulation of RNA biosynthetic process
LK411_RS20165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LK411_RS20175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LK411_RS20195	COG1116	anion transmembrane transporter activity
LK411_RS20200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK411_RS20210	COG1054	Belongs to the UPF0176 family
LK411_RS20260	COG2146	nitrite reductase [NAD(P)H] activity
LK411_RS20315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LK411_RS20325	COG3813	Protein conserved in bacteria
LK411_RS20365	COG0560	Phosphoserine phosphatase
LK411_RS20365	COG3830	Belongs to the UPF0237 family
LK411_RS20370	COG1523	belongs to the glycosyl hydrolase 13 family
LK411_RS20375	COG1119	ATPase activity
LK411_RS20390	COG2226	methyltransferase
LK411_RS20400	COG0436	Aminotransferase
LK411_RS20415	COG0024	Methionine aminopeptidase
LK411_RS20435	COG0110	maltose O-acetyltransferase activity
LK411_RS20455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LK411_RS20465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LK411_RS20530	COG0482	sulfurtransferase activity
LK411_RS20575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LK411_RS20590	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LK411_RS20595	COG1228	amidohydrolase
LK411_RS20605	COG2986	histidine ammonia-lyase
LK411_RS20625	COG1960	acyl-CoA dehydrogenase activity
LK411_RS20630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK411_RS20655	COG1231	oxidoreductase activity
LK411_RS20665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LK411_RS20670	COG2072	flavoprotein involved in K transport
LK411_RS20690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LK411_RS20695	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS20705	COG1012	belongs to the aldehyde dehydrogenase family
LK411_RS20715	COG1733	regulation of RNA biosynthetic process
LK411_RS20730	COG0154	amidase activity
LK411_RS20735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK411_RS20740	COG1959	2 iron, 2 sulfur cluster binding
LK411_RS20755	COG4585	Histidine kinase
LK411_RS20760	COG2197	response regulator
LK411_RS20765	COG0205	6-phosphofructokinase activity
LK411_RS20775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LK411_RS20790	COG0129	dihydroxy-acid dehydratase activity
LK411_RS20805	COG0440	acetolactate synthase activity
LK411_RS20810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LK411_RS20840	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS20855	COG0473	3-isopropylmalate dehydrogenase activity
LK411_RS20860	COG2271	Major facilitator Superfamily
LK411_RS20865	COG0179	Fumarylacetoacetate (FAA) hydrolase
LK411_RS20870	COG0589	response to stress
LK411_RS20875	COG0589	response to stress
LK411_RS20880	COG2814	Major facilitator Superfamily
LK411_RS20885	COG0673	inositol 2-dehydrogenase activity
LK411_RS20900	COG1609	Transcriptional regulator
LK411_RS20910	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK411_RS20920	COG0673	inositol 2-dehydrogenase activity
LK411_RS20925	COG0673	inositol 2-dehydrogenase activity
LK411_RS20930	COG1082	Xylose isomerase domain protein TIM barrel
LK411_RS20935	COG0673	inositol 2-dehydrogenase activity
LK411_RS20950	COG1028	Short-chain dehydrogenase reductase Sdr
LK411_RS20960	COG1609	Transcriptional regulator
LK411_RS20965	COG2188	Transcriptional regulator
LK411_RS20985	COG3718	enzyme involved in inositol metabolism
LK411_RS20990	COG3962	Belongs to the TPP enzyme family
LK411_RS21000	COG0673	inositol 2-dehydrogenase activity
LK411_RS21005	COG1082	Xylose isomerase domain protein TIM barrel
LK411_RS21010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK411_RS21040	COG1846	Transcriptional regulator
LK411_RS21050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LK411_RS21065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LK411_RS21070	COG0066	3-isopropylmalate dehydratase activity
LK411_RS21085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LK411_RS21095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LK411_RS21120	COG1725	Transcriptional regulator
LK411_RS21130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LK411_RS21135	COG1461	Dihydroxyacetone kinase
LK411_RS21140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LK411_RS21145	COG1309	transcriptional regulator
LK411_RS21150	COG1024	Enoyl-CoA hydratase
LK411_RS21165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK411_RS21170	COG1960	acyl-CoA dehydrogenase activity
LK411_RS21195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LK411_RS21210	COG0542	response to heat
LK411_RS21220	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LK411_RS21225	COG0799	negative regulation of ribosome biogenesis
LK411_RS21230	COG0406	alpha-ribazole phosphatase activity
LK411_RS21235	COG2755	lipolytic protein G-D-S-L family
LK411_RS21240	COG1307	EDD domain protein, DegV family
LK411_RS21245	COG1596	polysaccharide export
LK411_RS21245	COG1555	photosystem II stabilization
LK411_RS21260	COG0268	Binds directly to 16S ribosomal RNA
LK411_RS21265	COG2308	Evidence 4 Homologs of previously reported genes of
LK411_RS21275	COG1305	Transglutaminase-like
LK411_RS21310	COG1012	belongs to the aldehyde dehydrogenase family
LK411_RS21315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LK411_RS21325	COG0481	GTPase activity
LK411_RS21330	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LK411_RS21335	COG0656	L-ascorbic acid biosynthetic process
LK411_RS21340	COG2814	Major facilitator Superfamily
LK411_RS21365	COG2070	2-Nitropropane dioxygenase
LK411_RS21380	COG0339	signal peptide processing
LK411_RS21385	COG1733	regulation of RNA biosynthetic process
LK411_RS21410	COG3387	PFAM Glycoside hydrolase 15-related
LK411_RS21420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LK411_RS21430	COG4208	sulfate ABC transporter
LK411_RS21435	COG3842	ATPase activity
LK411_RS21440	COG4552	Acetyltransferase involved in intracellular survival and related
LK411_RS21460	COG0175	sulfate reduction
LK411_RS21490	COG1420	regulation of RNA biosynthetic process
LK411_RS21495	COG0484	heat shock protein binding
LK411_RS21520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LK411_RS21560	COG1381	Involved in DNA repair and RecF pathway recombination
LK411_RS21565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LK411_RS21580	COG1764	response to oxidative stress
LK411_RS21585	COG1846	Transcriptional regulator
LK411_RS21590	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LK411_RS21625	COG0423	glycine-tRNA ligase activity
LK411_RS21635	COG1278	Cold shock
LK411_RS21640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LK411_RS21645	COG0358	DNA primase activity
LK411_RS21785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK411_RS21800	COG2226	methyltransferase
LK411_RS21835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK411_RS21850	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LK411_RS21880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LK411_RS21915	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LK411_RS21915	COG3323	Protein of unknown function (DUF1653)
LK411_RS21955	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LK411_RS21975	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LK411_RS21980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LK411_RS21980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LK411_RS21995	COG0174	glutamine synthetase
LK411_RS22000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LK411_RS22035	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LK411_RS22040	COG2226	methyltransferase
LK411_RS22120	COG0582	viral genome integration into host DNA
LK411_RS22125	COG0174	glutamine synthetase
LK411_RS22140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LK411_RS22145	COG2814	Major facilitator Superfamily
LK411_RS22160	COG0321	lipoyl(octanoyl) transferase activity
LK411_RS22195	COG2233	PERMEase
LK411_RS22200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LK411_RS22205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LK411_RS22215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LK411_RS22235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK411_RS22245	COG0789	Transcriptional regulator
LK411_RS22260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LK411_RS22280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LK411_RS22290	COG2010	Cytochrome c
LK411_RS22295	COG1845	cytochrome c oxidase, subunit III
LK411_RS22305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LK411_RS22310	COG0442	prolyl-tRNA aminoacylation
LK411_RS22350	COG0438	transferase activity, transferring glycosyl groups
LK411_RS22390	COG1940	carbohydrate kinase activity
LK411_RS22405	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LK411_RS22425	COG2357	RelA SpoT domain protein
LK411_RS22455	COG4604	ABC transporter, ATP-binding protein
LK411_RS22470	COG4607	ABC-type enterochelin transport system periplasmic component
LK411_RS22475	COG0142	geranyltranstransferase activity
LK411_RS22510	COG2001	Belongs to the MraZ family
LK411_RS22515	COG0275	rRNA processing
LK411_RS22525	COG0768	penicillin binding
LK411_RS22660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LK411_RS22665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK411_RS22670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LK411_RS22685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LK411_RS22690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LK411_RS22695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LK411_RS22725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LK411_RS22760	COG0569	domain protein
LK411_RS22765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LK411_RS22770	COG0252	asparaginase activity
LK411_RS22785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LK411_RS22805	COG1090	epimerase
LK411_RS22835	COG1193	negative regulation of DNA recombination
LK411_RS22840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LK411_RS22850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LK411_RS22855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LK411_RS22880	COG0006	proline dipeptidase activity
LK411_RS22885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LK411_RS22890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LK411_RS22900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LK411_RS22920	COG0505	Belongs to the CarA family
LK411_RS22930	COG0284	orotidine-5'-phosphate decarboxylase activity
LK411_RS22940	COG0475	glutathione-regulated potassium exporter activity
LK411_RS22955	COG1758	RNA polymerase activity
LK411_RS22965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LK411_RS22995	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK411_RS23010	COG1522	sequence-specific DNA binding
LK411_RS23015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LK411_RS23025	COG0242	peptide deformylase activity
LK411_RS23030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LK411_RS23060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK411_RS23060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK411_RS23065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LK411_RS23090	COG3104	oligopeptide transport
LK411_RS23120	COG1715	Restriction endonuclease
LK411_RS23130	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LK411_RS23140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK411_RS23160	COG0318	PFAM AMP-dependent synthetase and ligase
LK411_RS23175	COG0322	excinuclease ABC activity
LK411_RS23195	COG3842	ATPase activity
LK411_RS23205	COG0405	Gamma-glutamyltransferase
LK411_RS23215	COG1660	Displays ATPase and GTPase activities
LK411_RS23220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LK411_RS23225	COG1481	regulation of sporulation
LK411_RS23235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LK411_RS23240	COG0126	phosphoglycerate kinase activity
LK411_RS23245	COG0149	triose-phosphate isomerase activity
LK411_RS23250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LK411_RS23260	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
LK411_RS23270	COG1960	acyl-CoA dehydrogenase activity
LK411_RS23295	COG0363	glucosamine-6-phosphate deaminase activity
LK411_RS23310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LK411_RS23320	COG0109	protoheme IX farnesyltransferase activity
LK411_RS23330	COG1309	transcriptional regulator
LK411_RS23360	COG1131	(ABC) transporter
LK411_RS23385	COG0396	ATPase activity
LK411_RS23400	COG2151	metal-sulfur cluster biosynthetic enzyme
LK411_RS23420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK411_RS23435	COG2188	Transcriptional regulator
LK411_RS23445	COG0667	Aldo Keto reductase
LK411_RS23460	COG1960	acyl-CoA dehydrogenase activity
LK411_RS23470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK411_RS23495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LK411_RS23505	COG1946	Acyl-CoA thioesterase
LK411_RS23515	COG0457	Tetratricopeptide repeat
LK411_RS23515	COG0705	Rhomboid family
LK411_RS23545	COG2132	Multicopper oxidase
LK411_RS23580	COG1316	TRANSCRIPTIONal
LK411_RS23585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs