locus-tag	class	description
TPB0596_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TPB0596_RS00015	COG0592	DNA-directed DNA polymerase activity
TPB0596_RS00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TPB0596_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TPB0596_RS00030	COG1819	glycosyl
TPB0596_RS00035	COG0477	Major facilitator Superfamily
TPB0596_RS00050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TPB0596_RS00060	COG0187	DNA topoisomerase II activity
TPB0596_RS00065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TPB0596_RS00085	COG1253	flavin adenine dinucleotide binding
TPB0596_RS00095	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TPB0596_RS00105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TPB0596_RS00170	COG0515	serine threonine protein kinase
TPB0596_RS00170	COG2815	serine threonine protein kinase
TPB0596_RS00175	COG0515	serine threonine protein kinase
TPB0596_RS00180	COG0768	penicillin binding
TPB0596_RS00195	COG1716	ATPase activity
TPB0596_RS00200	COG1716	ATPase activity
TPB0596_RS00385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TPB0596_RS00410	COG1120	ATPase activity
TPB0596_RS00435	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TPB0596_RS00440	COG2079	MmgE PrpD family protein
TPB0596_RS00445	COG3800	Transcriptional regulator
TPB0596_RS00445	COG1396	sequence-specific DNA binding
TPB0596_RS00495	COG0415	Belongs to the DNA photolyase family
TPB0596_RS00540	COG0438	transferase activity, transferring glycosyl groups
TPB0596_RS00570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TPB0596_RS00605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TPB0596_RS00665	COG2957	Belongs to the agmatine deiminase family
TPB0596_RS00675	COG2015	COG2015, Alkyl sulfatase and related hydrolases
TPB0596_RS00705	COG1073	alpha beta
TPB0596_RS00725	COG3336	cytochrome c oxidase
TPB0596_RS00750	COG0657	acetylesterase activity
TPB0596_RS00770	COG0778	Nitroreductase
TPB0596_RS00775	COG1376	ErfK ybiS ycfS ynhG family protein
TPB0596_RS00785	COG0640	Transcriptional regulator
TPB0596_RS00800	COG0745	RESPONSE REGULATOR receiver
TPB0596_RS00805	COG2205	protein histidine kinase activity
TPB0596_RS00820	COG0745	RESPONSE REGULATOR receiver
TPB0596_RS00825	COG2205	protein histidine kinase activity
TPB0596_RS00850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TPB0596_RS00855	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TPB0596_RS00860	COG3559	Exporter of polyketide antibiotics
TPB0596_RS00865	COG1131	(ABC) transporter
TPB0596_RS00890	COG0667	Aldo Keto reductase
TPB0596_RS00900	COG0070	glutamate synthase
TPB0596_RS00900	COG0069	glutamate synthase activity
TPB0596_RS00900	COG0067	glutamate synthase
TPB0596_RS00925	COG2501	S4 domain
TPB0596_RS00945	COG1012	belongs to the aldehyde dehydrogenase family
TPB0596_RS00995	COG2119	membrane
TPB0596_RS01055	COG1316	TRANSCRIPTIONal
TPB0596_RS01065	COG2252	PERMEase
TPB0596_RS01115	COG0813	purine-nucleoside phosphorylase activity
TPB0596_RS01130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TPB0596_RS01140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TPB0596_RS01140	COG2146	nitrite reductase [NAD(P)H] activity
TPB0596_RS01150	COG0561	phosphatase activity
TPB0596_RS01155	COG2385	sporulation resulting in formation of a cellular spore
TPB0596_RS01165	COG1216	Glycosyl transferase, family 2
TPB0596_RS01170	COG0671	phosphoesterase, PA-phosphatase related
TPB0596_RS01175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TPB0596_RS01180	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TPB0596_RS01195	COG5001	Diguanylate cyclase
TPB0596_RS01195	COG5002	protein histidine kinase activity
TPB0596_RS01215	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
TPB0596_RS01220	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
TPB0596_RS01230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS01240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPB0596_RS01240	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
TPB0596_RS01240	COG3321	synthase
TPB0596_RS01245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TPB0596_RS01250	COG0277	FAD linked oxidase domain protein
TPB0596_RS01255	COG1956	GAF domain-containing protein
TPB0596_RS01285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPB0596_RS01290	COG1349	DNA-binding transcription factor activity
TPB0596_RS01300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPB0596_RS01300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPB0596_RS01300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TPB0596_RS01315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TPB0596_RS01325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TPB0596_RS01330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TPB0596_RS01360	COG3191	aminopeptidase activity
TPB0596_RS01370	COG1846	Transcriptional regulator
TPB0596_RS01405	COG0477	Major facilitator Superfamily
TPB0596_RS01415	COG1396	sequence-specific DNA binding
TPB0596_RS01420	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TPB0596_RS01425	COG1760	l-serine dehydratase
TPB0596_RS01435	COG1051	belongs to the nudix hydrolase family
TPB0596_RS01440	COG3214	Protein conserved in bacteria
TPB0596_RS01450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TPB0596_RS01455	COG3559	Exporter of polyketide antibiotics
TPB0596_RS01460	COG1131	(ABC) transporter
TPB0596_RS01465	COG1309	transcriptional regulator
TPB0596_RS01475	COG0488	(ABC) transporter
TPB0596_RS01520	COG1674	ftsk spoiiie
TPB0596_RS01560	COG1404	Belongs to the peptidase S8 family
TPB0596_RS01605	COG1309	transcriptional regulator
TPB0596_RS01610	COG0183	Belongs to the thiolase family
TPB0596_RS01615	COG1024	Enoyl-CoA hydratase
TPB0596_RS01615	COG1250	3-hydroxyacyl-CoA dehydrogenase
TPB0596_RS01685	COG1309	transcriptional regulator
TPB0596_RS01730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TPB0596_RS01730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TPB0596_RS01735	COG2409	Drug exporters of the RND superfamily
TPB0596_RS01745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TPB0596_RS01785	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TPB0596_RS01800	COG0464	growth
TPB0596_RS01810	COG1136	(ABC) transporter
TPB0596_RS01810	COG0577	efflux transmembrane transporter activity
TPB0596_RS01820	COG1252	NADH dehydrogenase
TPB0596_RS01855	COG0492	ferredoxin-NADP+ reductase activity
TPB0596_RS01910	COG4981	capsule polysaccharide biosynthetic process
TPB0596_RS01930	COG1472	Belongs to the glycosyl hydrolase 3 family
TPB0596_RS01935	COG1309	transcriptional regulator
TPB0596_RS01940	COG2030	dehydratase
TPB0596_RS01945	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS01950	COG0183	Belongs to the thiolase family
TPB0596_RS01955	COG1832	CoA-binding protein
TPB0596_RS01980	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS01995	COG1309	transcriptional regulator
TPB0596_RS02000	COG0300	oxidoreductase activity
TPB0596_RS02015	COG0477	Major facilitator Superfamily
TPB0596_RS02035	COG1115	amino acid carrier protein
TPB0596_RS02045	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS02050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TPB0596_RS02055	COG2066	Belongs to the glutaminase family
TPB0596_RS02055	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
TPB0596_RS02060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TPB0596_RS02070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TPB0596_RS02150	COG3655	Transcriptional regulator
TPB0596_RS02315	COG0582	viral genome integration into host DNA
TPB0596_RS02360	COG2181	nitrate reductase activity
TPB0596_RS02360	COG0247	lactate metabolic process
TPB0596_RS02405	COG0708	Exodeoxyribonuclease III
TPB0596_RS02485	COG0443	Heat shock 70 kDa protein
TPB0596_RS02490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TPB0596_RS02495	COG0484	heat shock protein binding
TPB0596_RS02500	COG0789	Transcriptional regulator
TPB0596_RS02520	COG0154	amidase activity
TPB0596_RS02535	COG2267	carboxylic ester hydrolase activity
TPB0596_RS02555	COG2149	membrane
TPB0596_RS02575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TPB0596_RS02605	COG3609	addiction module antidote protein, CC2985 family
TPB0596_RS02615	COG0488	(ABC) transporter
TPB0596_RS02620	COG0586	Pfam SNARE associated Golgi protein
TPB0596_RS02625	COG0586	Pfam SNARE associated Golgi protein
TPB0596_RS02655	COG4129	membrane
TPB0596_RS02665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TPB0596_RS02680	COG2814	Major facilitator Superfamily
TPB0596_RS02685	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TPB0596_RS02695	COG1695	Transcriptional regulator
TPB0596_RS02710	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS02745	COG3142	Participates in the control of copper homeostasis
TPB0596_RS02760	COG1690	Belongs to the RtcB family
TPB0596_RS02790	COG0442	prolyl-tRNA aminoacylation
TPB0596_RS02815	COG2027	D-alanyl-D-alanine carboxypeptidase
TPB0596_RS02825	COG0037	tRNA processing
TPB0596_RS02830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TPB0596_RS02845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPB0596_RS02855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TPB0596_RS02885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TPB0596_RS02890	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TPB0596_RS02895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TPB0596_RS02905	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TPB0596_RS02925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TPB0596_RS02940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TPB0596_RS02965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TPB0596_RS02970	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TPB0596_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS02985	COG1194	a g-specific adenine glycosylase
TPB0596_RS02990	COG0288	reversible hydration of carbon dioxide
TPB0596_RS03005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TPB0596_RS03020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TPB0596_RS03035	COG0215	cysteine-tRNA ligase activity
TPB0596_RS03040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TPB0596_RS03050	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TPB0596_RS03055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TPB0596_RS03060	COG1116	anion transmembrane transporter activity
TPB0596_RS03080	COG1741	Belongs to the pirin family
TPB0596_RS03085	COG2267	carboxylic ester hydrolase activity
TPB0596_RS03090	COG0438	transferase activity, transferring glycosyl groups
TPB0596_RS03120	COG1309	transcriptional regulator
TPB0596_RS03130	COG0477	Major facilitator Superfamily
TPB0596_RS03140	COG0640	Transcriptional regulator
TPB0596_RS03155	COG0667	Aldo Keto reductase
TPB0596_RS03165	COG2318	DinB family
TPB0596_RS03175	COG1119	ATPase activity
TPB0596_RS03180	COG4106	trans-aconitate 2-methyltransferase activity
TPB0596_RS03185	COG0583	DNA-binding transcription factor activity
TPB0596_RS03190	COG2814	Major facilitator Superfamily
TPB0596_RS03195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS03210	COG1136	(ABC) transporter
TPB0596_RS03225	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
TPB0596_RS03240	COG0588	phosphoglycerate mutase activity
TPB0596_RS03250	COG5002	protein histidine kinase activity
TPB0596_RS03255	COG0745	RESPONSE REGULATOR receiver
TPB0596_RS03290	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TPB0596_RS03330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TPB0596_RS03335	COG0181	hydroxymethylbilane synthase activity
TPB0596_RS03340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TPB0596_RS03340	COG1648	precorrin-2 dehydrogenase activity
TPB0596_RS03370	COG2608	mercury ion transmembrane transporter activity
TPB0596_RS03375	COG2954	triphosphatase activity
TPB0596_RS03380	COG2409	Drug exporters of the RND superfamily
TPB0596_RS03405	COG2272	Belongs to the type-B carboxylesterase lipase family
TPB0596_RS03410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TPB0596_RS03415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TPB0596_RS03420	COG0406	alpha-ribazole phosphatase activity
TPB0596_RS03425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TPB0596_RS03430	COG0785	Cytochrome C biogenesis protein
TPB0596_RS03440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TPB0596_RS03455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TPB0596_RS03470	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS03505	COG3629	intracellular signal transduction
TPB0596_RS03560	COG4948	Mandelate Racemase Muconate Lactonizing
TPB0596_RS03580	COG0154	amidase activity
TPB0596_RS03590	COG2409	Drug exporters of the RND superfamily
TPB0596_RS03600	COG1937	Protein conserved in bacteria
TPB0596_RS03605	COG3268	Saccharopine dehydrogenase
TPB0596_RS03610	COG3180	Ammonia monooxygenase
TPB0596_RS03620	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TPB0596_RS03630	COG0438	transferase activity, transferring glycosyl groups
TPB0596_RS03635	COG2226	methyltransferase
TPB0596_RS03640	COG0142	geranyltranstransferase activity
TPB0596_RS03645	COG0501	Belongs to the peptidase M48B family
TPB0596_RS03650	COG1666	GTP binding
TPB0596_RS03675	COG2030	dehydratase
TPB0596_RS03680	COG2030	dehydratase
TPB0596_RS03700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TPB0596_RS03705	COG0081	regulation of translation
TPB0596_RS03735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TPB0596_RS03750	COG0085	RNA polymerase activity
TPB0596_RS03780	COG2814	Major facilitator Superfamily
TPB0596_RS03785	COG0179	Fumarylacetoacetate (FAA) hydrolase
TPB0596_RS03790	COG4948	Mandelate Racemase Muconate Lactonizing
TPB0596_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS03805	COG2186	Transcriptional regulator
TPB0596_RS03810	COG3304	Inner membrane component domain
TPB0596_RS03840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TPB0596_RS03855	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS03865	COG2376	Dihydroxyacetone kinase
TPB0596_RS03910	COG0640	Transcriptional regulator
TPB0596_RS03915	COG0765	amino acid transport
TPB0596_RS03920	COG1126	abc transporter atp-binding protein
TPB0596_RS03930	COG0384	phenazine biosynthesis protein PhzF
TPB0596_RS03935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TPB0596_RS03940	COG1263	PTS System
TPB0596_RS03945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TPB0596_RS03970	COG2311	Membrane
TPB0596_RS03975	COG2188	Transcriptional regulator
TPB0596_RS03985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS04060	COG1061	Type III restriction enzyme res subunit
TPB0596_RS04165	COG2814	Major facilitator Superfamily
TPB0596_RS04210	COG2814	Major facilitator Superfamily
TPB0596_RS04240	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TPB0596_RS04250	COG0259	pyridoxamine-phosphate oxidase activity
TPB0596_RS04255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TPB0596_RS04290	COG0545	Peptidyl-prolyl cis-trans isomerase
TPB0596_RS04320	COG0656	L-ascorbic acid biosynthetic process
TPB0596_RS04325	COG0492	ferredoxin-NADP+ reductase activity
TPB0596_RS04355	COG1408	metallophosphoesterase
TPB0596_RS04400	COG1218	3'(2'),5'-bisphosphate nucleotidase
TPB0596_RS04405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TPB0596_RS04435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TPB0596_RS04440	COG2364	Membrane
TPB0596_RS04455	COG2084	Dehydrogenase
TPB0596_RS04515	COG0739	heme binding
TPB0596_RS04520	COG1116	anion transmembrane transporter activity
TPB0596_RS04525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPB0596_RS04530	COG1285	pathogenesis
TPB0596_RS04540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TPB0596_RS04550	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS04565	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS04570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TPB0596_RS04625	COG2814	Major facilitator Superfamily
TPB0596_RS04660	COG0640	Transcriptional regulator
TPB0596_RS04675	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TPB0596_RS04700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TPB0596_RS04705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TPB0596_RS04715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TPB0596_RS04725	COG0254	rRNA binding
TPB0596_RS04735	COG2860	membrane
TPB0596_RS04755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPB0596_RS04760	COG0521	Mo-molybdopterin cofactor biosynthetic process
TPB0596_RS04795	COG1970	mechanosensitive ion channel activity
TPB0596_RS04835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TPB0596_RS04840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TPB0596_RS04850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TPB0596_RS04865	COG4974	Belongs to the 'phage' integrase family
TPB0596_RS05025	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TPB0596_RS05105	COG1733	regulation of RNA biosynthetic process
TPB0596_RS05130	COG5473	translation initiation factor activity
TPB0596_RS05135	COG2267	carboxylic ester hydrolase activity
TPB0596_RS05145	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TPB0596_RS05160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TPB0596_RS05185	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TPB0596_RS05195	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TPB0596_RS05205	COG0477	Major facilitator Superfamily
TPB0596_RS05250	COG0084	hydrolase, TatD family'
TPB0596_RS05265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TPB0596_RS05270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TPB0596_RS05285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TPB0596_RS05290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TPB0596_RS05295	COG0488	(ABC) transporter
TPB0596_RS05325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TPB0596_RS05335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPB0596_RS05340	COG0546	phosphoglycolate phosphatase activity
TPB0596_RS05375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TPB0596_RS05390	COG2154	pterin-4-alpha-carbinolamine dehydratase
TPB0596_RS05420	COG0456	acetyltransferase
TPB0596_RS05425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TPB0596_RS05480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TPB0596_RS05485	COG0459	protein refolding
TPB0596_RS05520	COG0516	GMP reductase activity
TPB0596_RS05540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TPB0596_RS05540	COG0519	Catalyzes the synthesis of GMP from XMP
TPB0596_RS05545	COG0702	epimerase
TPB0596_RS05565	COG2197	response regulator
TPB0596_RS05595	COG0833	amino acid
TPB0596_RS05640	COG0587	DNA-directed DNA polymerase activity
TPB0596_RS05660	COG1872	DUF167
TPB0596_RS05675	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TPB0596_RS05685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TPB0596_RS05705	COG2814	Major facilitator Superfamily
TPB0596_RS05720	COG0708	Exodeoxyribonuclease III
TPB0596_RS05725	COG0180	Tryptophanyl-tRNA synthetase
TPB0596_RS05730	COG1295	ribonuclease BN
TPB0596_RS05740	COG1686	Belongs to the peptidase S11 family
TPB0596_RS05790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TPB0596_RS05805	COG2009	succinate dehydrogenase
TPB0596_RS05820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TPB0596_RS05830	COG2197	response regulator
TPB0596_RS06230	COG3179	chitinase
TPB0596_RS06280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPB0596_RS06300	COG1473	amidohydrolase
TPB0596_RS06300	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TPB0596_RS06330	COG1595	DNA-templated transcription, initiation
TPB0596_RS06370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TPB0596_RS06375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TPB0596_RS06390	COG2197	response regulator
TPB0596_RS06400	COG0477	Major facilitator Superfamily
TPB0596_RS06410	COG3360	Dodecin
TPB0596_RS06425	COG1201	RNA secondary structure unwinding
TPB0596_RS06430	COG2272	Belongs to the type-B carboxylesterase lipase family
TPB0596_RS06440	COG0431	NADPH-dependent FMN reductase
TPB0596_RS06450	COG1396	sequence-specific DNA binding
TPB0596_RS06465	COG4770	biotin carboxylase activity
TPB0596_RS06500	COG2755	lipolytic protein G-D-S-L family
TPB0596_RS06520	COG0424	maF-like protein
TPB0596_RS06530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TPB0596_RS06545	COG0745	RESPONSE REGULATOR receiver
TPB0596_RS06555	COG2205	protein histidine kinase activity
TPB0596_RS06565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TPB0596_RS06580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPB0596_RS06600	COG1316	TRANSCRIPTIONal
TPB0596_RS06615	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPB0596_RS06620	COG2755	lipolytic protein G-D-S-L family
TPB0596_RS06625	COG4122	O-methyltransferase activity
TPB0596_RS06630	COG1595	DNA-templated transcription, initiation
TPB0596_RS06635	COG5662	AntiSigma factor
TPB0596_RS06640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPB0596_RS06645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TPB0596_RS06670	COG0745	RESPONSE REGULATOR receiver
TPB0596_RS06675	COG5002	protein histidine kinase activity
TPB0596_RS06680	COG5401	PFAM Sporulation and spore germination
TPB0596_RS06690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TPB0596_RS06695	COG0653	protein targeting
TPB0596_RS06760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TPB0596_RS06770	COG1162	GTPase activity
TPB0596_RS06775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TPB0596_RS06790	COG2135	peptidase activity
TPB0596_RS06795	COG1012	belongs to the aldehyde dehydrogenase family
TPB0596_RS06805	COG4221	oxidoreductase activity
TPB0596_RS06810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TPB0596_RS06815	COG1595	DNA-templated transcription, initiation
TPB0596_RS06845	COG0406	alpha-ribazole phosphatase activity
TPB0596_RS06870	COG1090	epimerase
TPB0596_RS06885	COG0513	Belongs to the DEAD box helicase family
TPB0596_RS06895	COG1309	transcriptional regulator
TPB0596_RS06900	COG0596	Alpha beta hydrolase
TPB0596_RS06945	COG0596	Alpha beta hydrolase
TPB0596_RS06965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TPB0596_RS07015	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS07040	COG3480	Lon protease (S16) C-terminal proteolytic domain
TPB0596_RS07050	COG1615	UPF0182 protein
TPB0596_RS07060	COG0110	maltose O-acetyltransferase activity
TPB0596_RS07070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS07080	COG0730	response to heat
TPB0596_RS07085	COG0456	acetyltransferase
TPB0596_RS07090	COG2814	Major facilitator Superfamily
TPB0596_RS07095	COG1388	LysM domain
TPB0596_RS07100	COG2409	Drug exporters of the RND superfamily
TPB0596_RS07105	COG2197	response regulator
TPB0596_RS07115	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS07120	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS07125	COG0483	inositol monophosphate 1-phosphatase activity
TPB0596_RS07135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TPB0596_RS07140	COG0668	transmembrane transport
TPB0596_RS07150	COG2884	Cell division ATP-binding protein ftsE
TPB0596_RS07155	COG2177	Part of the ABC transporter FtsEX involved in
TPB0596_RS07160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TPB0596_RS07195	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TPB0596_RS07210	COG1414	Transcriptional regulator
TPB0596_RS07225	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TPB0596_RS07230	COG0800	Aldolase
TPB0596_RS07235	COG2610	gluconate transmembrane transporter activity
TPB0596_RS07260	COG3634	alkyl hydroperoxide reductase activity
TPB0596_RS07295	COG0640	Transcriptional regulator
TPB0596_RS07305	COG2084	Dehydrogenase
TPB0596_RS07315	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TPB0596_RS07320	COG2267	carboxylic ester hydrolase activity
TPB0596_RS07335	COG1116	anion transmembrane transporter activity
TPB0596_RS07340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPB0596_RS07350	COG1054	Belongs to the UPF0176 family
TPB0596_RS07395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPB0596_RS07445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPB0596_RS07450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPB0596_RS07455	COG0655	NAD(P)H dehydrogenase (quinone) activity
TPB0596_RS07460	COG0783	Belongs to the Dps family
TPB0596_RS07470	COG2264	protein methyltransferase activity
TPB0596_RS07490	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS07525	COG0753	catalase activity
TPB0596_RS07545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TPB0596_RS07595	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TPB0596_RS07605	COG3813	Protein conserved in bacteria
TPB0596_RS07640	COG0560	Phosphoserine phosphatase
TPB0596_RS07640	COG3830	Belongs to the UPF0237 family
TPB0596_RS07645	COG1523	belongs to the glycosyl hydrolase 13 family
TPB0596_RS07650	COG1119	ATPase activity
TPB0596_RS07665	COG2226	methyltransferase
TPB0596_RS07675	COG0436	Aminotransferase
TPB0596_RS07690	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TPB0596_RS07695	COG0024	Methionine aminopeptidase
TPB0596_RS07705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TPB0596_RS07710	COG0110	maltose O-acetyltransferase activity
TPB0596_RS07735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TPB0596_RS07745	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TPB0596_RS07755	COG2197	response regulator
TPB0596_RS07760	COG4585	Histidine kinase
TPB0596_RS07765	COG2132	Multicopper oxidase
TPB0596_RS07830	COG0482	sulfurtransferase activity
TPB0596_RS07865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TPB0596_RS07895	COG0154	amidase activity
TPB0596_RS07910	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TPB0596_RS07915	COG1959	2 iron, 2 sulfur cluster binding
TPB0596_RS07930	COG4585	Histidine kinase
TPB0596_RS07935	COG2197	response regulator
TPB0596_RS07940	COG0205	6-phosphofructokinase activity
TPB0596_RS07950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPB0596_RS07965	COG0129	dihydroxy-acid dehydratase activity
TPB0596_RS07980	COG0440	acetolactate synthase activity
TPB0596_RS07985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TPB0596_RS08025	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS08040	COG0473	3-isopropylmalate dehydrogenase activity
TPB0596_RS08045	COG2271	Major facilitator Superfamily
TPB0596_RS08050	COG0179	Fumarylacetoacetate (FAA) hydrolase
TPB0596_RS08060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TPB0596_RS08095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPB0596_RS08110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TPB0596_RS08115	COG0066	3-isopropylmalate dehydratase activity
TPB0596_RS08130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TPB0596_RS08135	COG1920	GTP binding
TPB0596_RS08140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TPB0596_RS08145	COG1181	Belongs to the D-alanine--D-alanine ligase family
TPB0596_RS08165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TPB0596_RS08170	COG1461	Dihydroxyacetone kinase
TPB0596_RS08175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TPB0596_RS08180	COG1309	transcriptional regulator
TPB0596_RS08185	COG1024	Enoyl-CoA hydratase
TPB0596_RS08200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TPB0596_RS08205	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS08225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TPB0596_RS08250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TPB0596_RS08255	COG0799	negative regulation of ribosome biogenesis
TPB0596_RS08260	COG0406	alpha-ribazole phosphatase activity
TPB0596_RS08265	COG2755	lipolytic protein G-D-S-L family
TPB0596_RS08270	COG1307	EDD domain protein, DegV family
TPB0596_RS08275	COG1555	photosystem II stabilization
TPB0596_RS08275	COG1596	polysaccharide export
TPB0596_RS08295	COG0268	Binds directly to 16S ribosomal RNA
TPB0596_RS08310	COG1305	Transglutaminase-like
TPB0596_RS08330	COG1012	belongs to the aldehyde dehydrogenase family
TPB0596_RS08335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TPB0596_RS08345	COG0481	GTPase activity
TPB0596_RS08350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TPB0596_RS08355	COG0656	L-ascorbic acid biosynthetic process
TPB0596_RS08360	COG2814	Major facilitator Superfamily
TPB0596_RS08365	COG1846	Transcriptional regulator
TPB0596_RS08385	COG2070	2-Nitropropane dioxygenase
TPB0596_RS08395	COG0339	signal peptide processing
TPB0596_RS08410	COG3387	PFAM Glycoside hydrolase 15-related
TPB0596_RS08425	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TPB0596_RS08430	COG4208	sulfate ABC transporter
TPB0596_RS08435	COG3842	ATPase activity
TPB0596_RS08440	COG4552	Acetyltransferase involved in intracellular survival and related
TPB0596_RS08455	COG0175	sulfate reduction
TPB0596_RS08485	COG1420	regulation of RNA biosynthetic process
TPB0596_RS08490	COG0484	heat shock protein binding
TPB0596_RS08510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TPB0596_RS08530	COG1381	Involved in DNA repair and RecF pathway recombination
TPB0596_RS08535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TPB0596_RS08550	COG1764	response to oxidative stress
TPB0596_RS08555	COG1846	Transcriptional regulator
TPB0596_RS08560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TPB0596_RS08595	COG0423	glycine-tRNA ligase activity
TPB0596_RS08605	COG1278	Cold shock
TPB0596_RS08610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TPB0596_RS08615	COG0358	DNA primase activity
TPB0596_RS08640	COG0488	(ABC) transporter
TPB0596_RS08715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPB0596_RS08730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TPB0596_RS08760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TPB0596_RS08775	COG2409	Drug exporters of the RND superfamily
TPB0596_RS08835	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
TPB0596_RS08855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TPB0596_RS08860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPB0596_RS08860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPB0596_RS08875	COG0174	glutamine synthetase
TPB0596_RS08880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TPB0596_RS08910	COG0174	glutamine synthetase
TPB0596_RS08925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TPB0596_RS08945	COG0321	lipoyl(octanoyl) transferase activity
TPB0596_RS08980	COG2233	PERMEase
TPB0596_RS08985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TPB0596_RS08990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TPB0596_RS09005	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TPB0596_RS09025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TPB0596_RS09040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TPB0596_RS09070	COG2010	Cytochrome c
TPB0596_RS09075	COG1845	cytochrome c oxidase, subunit III
TPB0596_RS09085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TPB0596_RS09090	COG0442	prolyl-tRNA aminoacylation
TPB0596_RS09125	COG0438	transferase activity, transferring glycosyl groups
TPB0596_RS09155	COG1940	carbohydrate kinase activity
TPB0596_RS09160	COG0765	amino acid transport
TPB0596_RS09180	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TPB0596_RS09200	COG2357	RelA SpoT domain protein
TPB0596_RS09205	COG0515	serine threonine protein kinase
TPB0596_RS09205	COG2815	serine threonine protein kinase
TPB0596_RS09225	COG4604	ABC transporter, ATP-binding protein
TPB0596_RS09240	COG4607	ABC-type enterochelin transport system periplasmic component
TPB0596_RS09245	COG0142	geranyltranstransferase activity
TPB0596_RS09280	COG2001	Belongs to the MraZ family
TPB0596_RS09285	COG0275	rRNA processing
TPB0596_RS09295	COG0768	penicillin binding
TPB0596_RS09310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPB0596_RS09315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TPB0596_RS09330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TPB0596_RS09335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TPB0596_RS09340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TPB0596_RS09350	COG1799	cell septum assembly
TPB0596_RS09370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TPB0596_RS09405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TPB0596_RS09410	COG0252	asparaginase activity
TPB0596_RS09425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TPB0596_RS09445	COG1090	epimerase
TPB0596_RS09480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TPB0596_RS09485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TPB0596_RS09510	COG0006	proline dipeptidase activity
TPB0596_RS09515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TPB0596_RS09530	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TPB0596_RS09550	COG0505	Belongs to the CarA family
TPB0596_RS09555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TPB0596_RS09560	COG0284	orotidine-5'-phosphate decarboxylase activity
TPB0596_RS09570	COG0475	glutathione-regulated potassium exporter activity
TPB0596_RS09580	COG0194	GDP metabolic process
TPB0596_RS09585	COG1758	RNA polymerase activity
TPB0596_RS09595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TPB0596_RS09625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TPB0596_RS09635	COG0242	peptide deformylase activity
TPB0596_RS09640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TPB0596_RS09670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TPB0596_RS09670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TPB0596_RS09675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TPB0596_RS09700	COG3104	oligopeptide transport
TPB0596_RS09740	COG0322	excinuclease ABC activity
TPB0596_RS09760	COG3842	ATPase activity
TPB0596_RS09770	COG0405	Gamma-glutamyltransferase
TPB0596_RS09785	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TPB0596_RS09790	COG1481	regulation of sporulation
TPB0596_RS09800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TPB0596_RS09805	COG0126	phosphoglycerate kinase activity
TPB0596_RS09820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TPB0596_RS09825	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
TPB0596_RS09830	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS09885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TPB0596_RS09895	COG0109	protoheme IX farnesyltransferase activity
TPB0596_RS09905	COG1309	transcriptional regulator
TPB0596_RS09935	COG1131	(ABC) transporter
TPB0596_RS09960	COG0396	ATPase activity
TPB0596_RS09975	COG2151	metal-sulfur cluster biosynthetic enzyme
TPB0596_RS10020	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS10030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TPB0596_RS10055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TPB0596_RS10065	COG1946	Acyl-CoA thioesterase
TPB0596_RS10075	COG0705	Rhomboid family
TPB0596_RS10075	COG0457	Tetratricopeptide repeat
TPB0596_RS10095	COG3243	poly(R)-hydroxyalkanoic acid synthase
TPB0596_RS10125	COG1278	Cold shock
TPB0596_RS10175	COG1733	regulation of RNA biosynthetic process
TPB0596_RS10190	COG3634	alkyl hydroperoxide reductase activity
TPB0596_RS10195	COG0477	Major facilitator Superfamily
TPB0596_RS10205	COG2409	Drug exporters of the RND superfamily
TPB0596_RS10220	COG0596	Alpha beta hydrolase
TPB0596_RS10235	COG0583	DNA-binding transcription factor activity
TPB0596_RS10240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TPB0596_RS10250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPB0596_RS10255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TPB0596_RS10260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TPB0596_RS10390	COG1024	Enoyl-CoA hydratase
TPB0596_RS10420	COG1285	pathogenesis
TPB0596_RS10440	COG0531	amino acid
TPB0596_RS10450	COG4303	Ethanolamine ammonia lyase large subunit
TPB0596_RS10480	COG0435	Glutathione S-transferase
TPB0596_RS10485	COG1902	pentaerythritol trinitrate reductase activity
TPB0596_RS10490	COG0789	Transcriptional regulator
TPB0596_RS10505	COG0596	Alpha beta hydrolase
TPB0596_RS10515	COG0477	Major facilitator Superfamily
TPB0596_RS10530	COG0789	Transcriptional regulator
TPB0596_RS10540	COG3422	double-strand break repair
TPB0596_RS10545	COG4260	virion core protein, lumpy skin disease virus
TPB0596_RS10600	COG2226	methyltransferase
TPB0596_RS10605	COG0539	negative regulation of cytoplasmic translation
TPB0596_RS10610	COG3842	ATPase activity
TPB0596_RS10615	COG0395	ABC-type sugar transport system, permease component
TPB0596_RS10620	COG1175	transmembrane transport
TPB0596_RS10635	COG1063	alcohol dehydrogenase
TPB0596_RS10640	COG0246	Mannitol dehydrogenase
TPB0596_RS10645	COG1070	Carbohydrate kinase
TPB0596_RS10655	COG0237	dephospho-CoA kinase activity
TPB0596_RS10655	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TPB0596_RS10665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TPB0596_RS10695	COG3973	AAA domain
TPB0596_RS10705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPB0596_RS10715	COG0405	Gamma-glutamyltransferase
TPB0596_RS10740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TPB0596_RS10745	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TPB0596_RS10760	COG2233	PERMEase
TPB0596_RS10770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TPB0596_RS10775	COG0072	phenylalanine-tRNA ligase activity
TPB0596_RS10775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPB0596_RS10780	COG2072	flavoprotein involved in K transport
TPB0596_RS10805	COG1024	Enoyl-CoA hydratase
TPB0596_RS10820	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TPB0596_RS10825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TPB0596_RS10835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TPB0596_RS10840	COG1438	arginine binding
TPB0596_RS10845	COG0137	argininosuccinate synthase activity
TPB0596_RS10850	COG0165	Argininosuccinate lyase
TPB0596_RS10865	COG1131	(ABC) transporter
TPB0596_RS10870	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS10895	COG2835	tetraacyldisaccharide 4'-kinase activity
TPB0596_RS10905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TPB0596_RS10930	COG0647	UMP catabolic process
TPB0596_RS10965	COG0504	CTP synthase activity
TPB0596_RS10970	COG0494	nUDIX hydrolase
TPB0596_RS10985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TPB0596_RS10990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TPB0596_RS11005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TPB0596_RS11010	COG1160	GTP binding
TPB0596_RS11040	COG2365	Tyrosine phosphatase family
TPB0596_RS11065	COG2249	NAD(P)H dehydrogenase (quinone) activity
TPB0596_RS11090	COG0596	Alpha beta hydrolase
TPB0596_RS11100	COG2234	aminopeptidase activity
TPB0596_RS11115	COG0509	glycine decarboxylation via glycine cleavage system
TPB0596_RS11120	COG1716	ATPase activity
TPB0596_RS11140	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TPB0596_RS11140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TPB0596_RS11155	COG1309	transcriptional regulator
TPB0596_RS11160	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS11170	COG1403	HNH endonuclease
TPB0596_RS11225	COG1120	ATPase activity
TPB0596_RS11230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPB0596_RS11245	COG1253	flavin adenine dinucleotide binding
TPB0596_RS11330	COG4762	Protein conserved in bacteria
TPB0596_RS11355	COG1074	ATP-dependent DNA helicase activity
TPB0596_RS11360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TPB0596_RS11370	COG1063	alcohol dehydrogenase
TPB0596_RS11400	COG2268	Band 7 protein
TPB0596_RS11500	COG0297	glycogen (starch) synthase activity
TPB0596_RS11505	COG0438	transferase activity, transferring glycosyl groups
TPB0596_RS11510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TPB0596_RS11525	COG0736	holo-[acyl-carrier-protein] synthase activity
TPB0596_RS11540	COG4106	trans-aconitate 2-methyltransferase activity
TPB0596_RS11575	COG2354	Protein conserved in bacteria
TPB0596_RS11600	COG1280	lysine exporter protein (LysE YggA)
TPB0596_RS11605	COG1250	3-hydroxyacyl-CoA dehydrogenase
TPB0596_RS11620	COG0477	Major facilitator Superfamily
TPB0596_RS11625	COG1984	allophanate hydrolase subunit 2
TPB0596_RS11655	COG2072	flavoprotein involved in K transport
TPB0596_RS11680	COG0798	PFAM Bile acid sodium symporter
TPB0596_RS11685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TPB0596_RS11710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TPB0596_RS11720	COG2807	transmembrane transport
TPB0596_RS11725	COG2186	Transcriptional regulator
TPB0596_RS11745	COG1454	alcohol dehydrogenase
TPB0596_RS11770	COG2072	flavoprotein involved in K transport
TPB0596_RS11775	COG1376	ErfK ybiS ycfS ynhG family protein
TPB0596_RS11800	COG0463	Glycosyl transferase, family 2
TPB0596_RS11810	COG1228	amidohydrolase
TPB0596_RS11840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TPB0596_RS11860	COG3467	pyridoxamine 5'-phosphate
TPB0596_RS11905	COG0300	oxidoreductase activity
TPB0596_RS11915	COG0477	Major facilitator Superfamily
TPB0596_RS11945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TPB0596_RS11950	COG2378	regulation of single-species biofilm formation
TPB0596_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS11980	COG0733	neurotransmitter:sodium symporter activity
TPB0596_RS11990	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TPB0596_RS11995	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TPB0596_RS12035	COG1131	(ABC) transporter
TPB0596_RS12035	COG0842	Transport permease protein
TPB0596_RS12035	COG1716	ATPase activity
TPB0596_RS12040	COG1222	aaa ATPase
TPB0596_RS12060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TPB0596_RS12065	COG0140	phosphoribosyl-ATP diphosphatase activity
TPB0596_RS12080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TPB0596_RS12090	COG5504	Zn-dependent protease
TPB0596_RS12100	COG0646	methionine synthase
TPB0596_RS12100	COG1410	methionine synthase
TPB0596_RS12115	COG0215	cysteine-tRNA ligase activity
TPB0596_RS12125	COG3220	belongs to the UPF0276 family
TPB0596_RS12150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TPB0596_RS12155	COG0583	DNA-binding transcription factor activity
TPB0596_RS12160	COG1968	undecaprenyl-diphosphatase activity
TPB0596_RS12175	COG0167	dihydroorotate dehydrogenase activity
TPB0596_RS12185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TPB0596_RS12225	COG3265	gluconokinase activity
TPB0596_RS12270	COG0531	amino acid
TPB0596_RS12280	COG5001	Diguanylate cyclase
TPB0596_RS12290	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TPB0596_RS12295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TPB0596_RS12305	COG0028	Belongs to the TPP enzyme family
TPB0596_RS12315	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TPB0596_RS12340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TPB0596_RS12345	COG2186	Transcriptional regulator
TPB0596_RS12445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TPB0596_RS12450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TPB0596_RS12470	COG0714	Associated with various cellular activities
TPB0596_RS12475	COG3883	PFAM NLP P60 protein
TPB0596_RS12475	COG0791	NLP P60 protein
TPB0596_RS12485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TPB0596_RS12490	COG1309	transcriptional regulator
TPB0596_RS12510	COG0584	glycerophosphoryl diester phosphodiesterase
TPB0596_RS12540	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS12545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TPB0596_RS12550	COG1309	transcriptional regulator
TPB0596_RS12555	COG1819	glycosyl
TPB0596_RS12570	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS12575	COG0488	(ABC) transporter
TPB0596_RS12585	COG0159	tryptophan synthase activity
TPB0596_RS12600	COG0765	amino acid transport
TPB0596_RS12605	COG1126	abc transporter atp-binding protein
TPB0596_RS12615	COG2188	Transcriptional regulator
TPB0596_RS12620	COG2814	Major facilitator Superfamily
TPB0596_RS12625	COG2971	BadF BadG BcrA BcrD
TPB0596_RS12630	COG0134	indole-3-glycerol-phosphate synthase activity
TPB0596_RS12640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TPB0596_RS12650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TPB0596_RS12655	COG0107	imidazoleglycerol-phosphate synthase activity
TPB0596_RS12660	COG0483	inositol monophosphate 1-phosphatase activity
TPB0596_RS12665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TPB0596_RS12675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TPB0596_RS12695	COG1414	Transcriptional regulator
TPB0596_RS12700	COG2252	PERMEase
TPB0596_RS12710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TPB0596_RS12720	COG0402	S-adenosylhomocysteine deaminase activity
TPB0596_RS12730	COG3257	ureidoglycine aminohydrolase activity
TPB0596_RS12740	COG1953	Uracil, thiamine, allantoin
TPB0596_RS12745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TPB0596_RS12755	COG0131	Imidazoleglycerol-phosphate dehydratase
TPB0596_RS12760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TPB0596_RS12765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TPB0596_RS12770	COG1535	isochorismatase
TPB0596_RS12770	COG3433	isochorismatase activity
TPB0596_RS12810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TPB0596_RS12825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS12850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TPB0596_RS12860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TPB0596_RS12865	COG0156	8-amino-7-oxononanoate synthase activity
TPB0596_RS12870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TPB0596_RS12890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS12895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS12920	COG4585	Histidine kinase
TPB0596_RS12925	COG2197	response regulator
TPB0596_RS12935	COG1126	abc transporter atp-binding protein
TPB0596_RS12950	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS12955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS12960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS12965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS12970	COG1846	Transcriptional regulator
TPB0596_RS12985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TPB0596_RS12990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TPB0596_RS13000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPB0596_RS13030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPB0596_RS13035	COG0444	Belongs to the ABC transporter superfamily
TPB0596_RS13040	COG1116	anion transmembrane transporter activity
TPB0596_RS13055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TPB0596_RS13075	COG0277	FAD linked oxidase domain protein
TPB0596_RS13090	COG0523	cobalamin synthesis protein
TPB0596_RS13110	COG0124	histidyl-tRNA synthetase
TPB0596_RS13125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TPB0596_RS13135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPB0596_RS13145	COG1862	Preprotein translocase
TPB0596_RS13150	COG0514	ATP-dependent DNA helicase (RecQ)
TPB0596_RS13165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TPB0596_RS13170	COG2255	four-way junction helicase activity
TPB0596_RS13180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TPB0596_RS13190	COG0217	transcriptional regulatory protein
TPB0596_RS13200	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TPB0596_RS13205	COG1946	Acyl-CoA thioesterase
TPB0596_RS13220	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TPB0596_RS13240	COG0438	transferase activity, transferring glycosyl groups
TPB0596_RS13245	COG1560	Kdo2-lipid A biosynthetic process
TPB0596_RS13260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TPB0596_RS13325	COG3321	synthase
TPB0596_RS13325	COG0604	alcohol dehydrogenase
TPB0596_RS13325	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS13340	COG0706	membrane insertase activity
TPB0596_RS13375	COG1937	Protein conserved in bacteria
TPB0596_RS13400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TPB0596_RS13405	COG3253	May function as heme-dependent peroxidase
TPB0596_RS13415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TPB0596_RS13430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TPB0596_RS13435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TPB0596_RS13455	COG0756	dUTP diphosphatase activity
TPB0596_RS13510	COG4770	biotin carboxylase activity
TPB0596_RS13515	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS13530	COG2267	carboxylic ester hydrolase activity
TPB0596_RS13535	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS13545	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS13550	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS13570	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS13575	COG1011	Hydrolase
TPB0596_RS13585	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS13590	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS13595	COG0183	Belongs to the thiolase family
TPB0596_RS13615	COG3590	peptidase
TPB0596_RS13650	COG2890	protein-(glutamine-N5) methyltransferase activity
TPB0596_RS13665	COG0123	including yeast histone deacetylase and acetoin utilization protein
TPB0596_RS13715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TPB0596_RS13735	COG0583	DNA-binding transcription factor activity
TPB0596_RS13755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TPB0596_RS13770	COG1643	Atp-dependent helicase
TPB0596_RS13775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TPB0596_RS13785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TPB0596_RS13805	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS13810	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS13825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TPB0596_RS13830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TPB0596_RS13835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TPB0596_RS13845	COG1196	nuclear chromosome segregation
TPB0596_RS13860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPB0596_RS13865	COG1126	abc transporter atp-binding protein
TPB0596_RS13870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TPB0596_RS13875	COG0765	amino acid transport
TPB0596_RS13880	COG0765	amino acid transport
TPB0596_RS13885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TPB0596_RS13895	COG2137	regulation of response to DNA damage stimulus
TPB0596_RS13900	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TPB0596_RS13950	COG1842	Phage shock protein A
TPB0596_RS13955	COG1396	sequence-specific DNA binding
TPB0596_RS13960	COG1058	Belongs to the CinA family
TPB0596_RS13960	COG1546	Belongs to the CinA family
TPB0596_RS13970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TPB0596_RS14025	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TPB0596_RS14030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TPB0596_RS14040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TPB0596_RS14085	COG2409	Drug exporters of the RND superfamily
TPB0596_RS14095	COG3486	L-lysine 6-monooxygenase (NADPH) activity
TPB0596_RS14115	COG1063	alcohol dehydrogenase
TPB0596_RS14120	COG1522	sequence-specific DNA binding
TPB0596_RS14125	COG0686	Belongs to the AlaDH PNT family
TPB0596_RS14140	COG0584	glycerophosphoryl diester phosphodiesterase
TPB0596_RS14165	COG1185	polyribonucleotide nucleotidyltransferase activity
TPB0596_RS14170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TPB0596_RS14170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TPB0596_RS14175	COG3540	Alkaline phosphatase
TPB0596_RS14195	COG1321	iron dependent repressor
TPB0596_RS14205	COG4607	ABC-type enterochelin transport system periplasmic component
TPB0596_RS14215	COG0372	Belongs to the citrate synthase family
TPB0596_RS14225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TPB0596_RS14235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TPB0596_RS14240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPB0596_RS14285	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TPB0596_RS14290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TPB0596_RS14300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TPB0596_RS14300	COG0481	GTPase activity
TPB0596_RS14315	COG0779	Required for maturation of 30S ribosomal subunits
TPB0596_RS14350	COG0442	prolyl-tRNA aminoacylation
TPB0596_RS14355	COG3022	response to hydroperoxide
TPB0596_RS14375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TPB0596_RS14375	COG1648	precorrin-2 dehydrogenase activity
TPB0596_RS14405	COG0579	oxidoreductase
TPB0596_RS14425	COG1492	cobalamin metabolic process
TPB0596_RS14450	COG0768	penicillin binding
TPB0596_RS14480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TPB0596_RS14485	COG0750	zinc metalloprotease
TPB0596_RS14490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TPB0596_RS14505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TPB0596_RS14510	COG5416	Lipopolysaccharide assembly protein A domain
TPB0596_RS14520	COG0575	Belongs to the CDS family
TPB0596_RS14525	COG0233	cytoplasmic translational termination
TPB0596_RS14530	COG0528	UMP kinase activity
TPB0596_RS14550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TPB0596_RS14555	COG0052	Belongs to the universal ribosomal protein uS2 family
TPB0596_RS14560	COG1115	amino acid carrier protein
TPB0596_RS14565	COG3226	Transcriptional regulator
TPB0596_RS14585	COG1823	symporter activity
TPB0596_RS14595	COG0443	Heat shock 70 kDa protein
TPB0596_RS14605	COG2814	Major facilitator Superfamily
TPB0596_RS14610	COG0501	Belongs to the peptidase M48B family
TPB0596_RS14630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TPB0596_RS14640	COG4974	Belongs to the 'phage' integrase family
TPB0596_RS14645	COG0477	Major facilitator Superfamily
TPB0596_RS14650	COG2011	ABC-type metal ion transport system permease component
TPB0596_RS14655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TPB0596_RS14685	COG0792	nuclease activity
TPB0596_RS14705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TPB0596_RS14710	COG0681	Belongs to the peptidase S26 family
TPB0596_RS14715	COG1012	belongs to the aldehyde dehydrogenase family
TPB0596_RS14720	COG0335	large ribosomal subunit rRNA binding
TPB0596_RS14760	COG0336	Belongs to the RNA methyltransferase TrmD family
TPB0596_RS14765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TPB0596_RS14775	COG0228	four-way junction DNA binding
TPB0596_RS14780	COG0076	glutamate decarboxylase activity
TPB0596_RS14805	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TPB0596_RS14860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS14875	COG0829	nickel cation binding
TPB0596_RS14880	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TPB0596_RS14885	COG0830	nickel cation binding
TPB0596_RS14890	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TPB0596_RS14895	COG0804	urea catabolic process
TPB0596_RS14900	COG0832	Belongs to the urease beta subunit family
TPB0596_RS14905	COG0831	urea catabolic process
TPB0596_RS14970	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TPB0596_RS14990	COG1196	nuclear chromosome segregation
TPB0596_RS14995	COG3766	membrane
TPB0596_RS15000	COG0754	glutathionylspermidine amidase activity
TPB0596_RS15010	COG1254	Belongs to the acylphosphatase family
TPB0596_RS15040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TPB0596_RS15065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TPB0596_RS15070	COG0571	ribonuclease III activity
TPB0596_RS15080	COG3599	regulation of cell shape
TPB0596_RS15085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TPB0596_RS15090	COG0742	ribosomal rna small subunit methyltransferase
TPB0596_RS15095	COG0477	Major facilitator Superfamily
TPB0596_RS15115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TPB0596_RS15120	COG4257	antibiotic catabolic process
TPB0596_RS15125	COG0456	acetyltransferase
TPB0596_RS15135	COG1917	Cupin 2, conserved barrel domain protein
TPB0596_RS15150	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TPB0596_RS15165	COG0477	Major facilitator Superfamily
TPB0596_RS15170	COG2814	Major facilitator Superfamily
TPB0596_RS15170	COG0477	Major facilitator Superfamily
TPB0596_RS15175	COG0598	Magnesium transport protein CorA
TPB0596_RS15200	COG0740	serine-type endopeptidase activity
TPB0596_RS15205	COG0740	serine-type endopeptidase activity
TPB0596_RS15230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS15235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TPB0596_RS15240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPB0596_RS15245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TPB0596_RS15255	COG1530	ribonuclease E activity
TPB0596_RS15260	COG0105	UTP biosynthetic process
TPB0596_RS15270	COG0285	dihydrofolate synthase activity
TPB0596_RS15275	COG0525	valine-tRNA ligase activity
TPB0596_RS15280	COG2321	neutral zinc metallopeptidase
TPB0596_RS15290	COG0488	(ABC) transporter
TPB0596_RS15300	COG0740	serine-type endopeptidase activity
TPB0596_RS15305	COG0740	serine-type endopeptidase activity
TPB0596_RS15310	COG0544	peptidyl-prolyl cis-trans isomerase activity
TPB0596_RS15320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TPB0596_RS15340	COG3189	MarR family transcriptional regulator
TPB0596_RS15365	COG0515	serine threonine protein kinase
TPB0596_RS15370	COG3135	benzoate transporter
TPB0596_RS15375	COG1396	sequence-specific DNA binding
TPB0596_RS15385	COG1120	ATPase activity
TPB0596_RS15390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPB0596_RS15400	COG3340	Belongs to the peptidase S51 family
TPB0596_RS15480	COG1024	Enoyl-CoA hydratase
TPB0596_RS15485	COG1396	sequence-specific DNA binding
TPB0596_RS15495	COG0531	amino acid
TPB0596_RS15500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPB0596_RS15525	COG2197	response regulator
TPB0596_RS15570	COG0698	ribose 5-phosphate isomerase
TPB0596_RS15580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TPB0596_RS15595	COG3012	SEC-C Motif Domain Protein
TPB0596_RS15600	COG0477	Major facilitator Superfamily
TPB0596_RS15605	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TPB0596_RS15620	COG2203	Gaf domain
TPB0596_RS15620	COG2199	diguanylate cyclase activity
TPB0596_RS15630	COG0366	Alpha amylase catalytic
TPB0596_RS15655	COG2902	Dehydrogenase
TPB0596_RS15685	COG0243	molybdopterin cofactor binding
TPB0596_RS15695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TPB0596_RS15695	COG2146	nitrite reductase [NAD(P)H] activity
TPB0596_RS15700	COG2146	nitrite reductase [NAD(P)H] activity
TPB0596_RS15700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TPB0596_RS15745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS15770	COG1131	(ABC) transporter
TPB0596_RS15790	COG4565	transcriptional regulatory protein
TPB0596_RS15795	COG3290	protein histidine kinase activity
TPB0596_RS15800	COG2851	Citrate transporter
TPB0596_RS15820	COG1695	Transcriptional regulator
TPB0596_RS15825	COG0446	pyridine nucleotide-disulphide oxidoreductase
TPB0596_RS15825	COG1902	pentaerythritol trinitrate reductase activity
TPB0596_RS15830	COG2259	Doxx family
TPB0596_RS15835	COG0300	oxidoreductase activity
TPB0596_RS15845	COG0433	COG0433 Predicted ATPase
TPB0596_RS15855	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TPB0596_RS15945	COG0067	glutamate synthase
TPB0596_RS15945	COG0070	glutamate synthase
TPB0596_RS15945	COG0069	glutamate synthase activity
TPB0596_RS15950	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TPB0596_RS15965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TPB0596_RS15980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TPB0596_RS16000	COG3402	PFAM membrane-flanked domain
TPB0596_RS16005	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS16060	COG1846	Transcriptional regulator
TPB0596_RS16115	COG1376	ErfK ybiS ycfS ynhG family protein
TPB0596_RS16120	COG1252	NADH dehydrogenase
TPB0596_RS16125	COG0583	DNA-binding transcription factor activity
TPB0596_RS16140	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS16155	COG0439	Biotin carboxylase
TPB0596_RS16165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TPB0596_RS16170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TPB0596_RS16190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TPB0596_RS16260	COG1316	TRANSCRIPTIONal
TPB0596_RS16265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TPB0596_RS16270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TPB0596_RS16275	COG1234	tRNA 3'-trailer cleavage
TPB0596_RS16310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TPB0596_RS16315	COG1335	isochorismatase
TPB0596_RS16320	COG2267	carboxylic ester hydrolase activity
TPB0596_RS16345	COG2351	hydroxyisourate hydrolase activity
TPB0596_RS16355	COG2233	PERMEase
TPB0596_RS16360	COG3622	Belongs to the hyi family
TPB0596_RS16365	COG2084	Dehydrogenase
TPB0596_RS16370	COG3960	tartronate-semialdehyde synthase activity
TPB0596_RS16375	COG1929	Belongs to the glycerate kinase type-1 family
TPB0596_RS16395	COG0583	DNA-binding transcription factor activity
TPB0596_RS16400	COG0477	Major facilitator Superfamily
TPB0596_RS16415	COG0366	Alpha amylase catalytic
TPB0596_RS16420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TPB0596_RS16425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPB0596_RS16435	COG0579	oxidoreductase
TPB0596_RS16445	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS16450	COG0657	acetylesterase activity
TPB0596_RS16455	COG0395	ABC-type sugar transport system, permease component
TPB0596_RS16460	COG1175	transmembrane transport
TPB0596_RS16485	COG0183	Belongs to the thiolase family
TPB0596_RS16505	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TPB0596_RS16545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TPB0596_RS16550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TPB0596_RS16555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TPB0596_RS16570	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TPB0596_RS16575	COG0356	it plays a direct role in the translocation of protons across the membrane
TPB0596_RS16585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPB0596_RS16590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPB0596_RS16595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPB0596_RS16640	COG2890	protein-(glutamine-N5) methyltransferase activity
TPB0596_RS16645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TPB0596_RS16650	COG0254	rRNA binding
TPB0596_RS16665	COG0083	homoserine kinase activity
TPB0596_RS16670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TPB0596_RS16675	COG0460	homoserine dehydrogenase
TPB0596_RS16785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TPB0596_RS16790	COG2814	Major facilitator Superfamily
TPB0596_RS16795	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS16820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TPB0596_RS16840	COG0508	dehydrogenase complex catalyzes the overall conversion of
TPB0596_RS16840	COG0567	Dehydrogenase, E1 component
TPB0596_RS16845	COG1309	transcriptional regulator
TPB0596_RS16860	COG0598	Magnesium transport protein CorA
TPB0596_RS16930	COG2239	Acts as a magnesium transporter
TPB0596_RS16945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TPB0596_RS16955	COG0531	amino acid
TPB0596_RS16980	COG1250	3-hydroxyacyl-CoA dehydrogenase
TPB0596_RS16985	COG1482	cell wall glycoprotein biosynthetic process
TPB0596_RS17015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TPB0596_RS17030	COG0300	oxidoreductase activity
TPB0596_RS17035	COG1073	alpha beta
TPB0596_RS17035	COG2226	methyltransferase
TPB0596_RS17040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TPB0596_RS17045	COG0297	glycogen (starch) synthase activity
TPB0596_RS17070	COG0789	Transcriptional regulator
TPB0596_RS17085	COG0463	Glycosyl transferase, family 2
TPB0596_RS17090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TPB0596_RS17095	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS17100	COG1611	Belongs to the LOG family
TPB0596_RS17105	COG1611	Belongs to the LOG family
TPB0596_RS17110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TPB0596_RS17115	COG2239	Acts as a magnesium transporter
TPB0596_RS17145	COG3220	belongs to the UPF0276 family
TPB0596_RS17160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TPB0596_RS17170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TPB0596_RS17180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TPB0596_RS17185	COG0747	negative chemotaxis
TPB0596_RS17200	COG0667	Aldo Keto reductase
TPB0596_RS17210	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TPB0596_RS17215	COG3842	ATPase activity
TPB0596_RS17250	COG0738	Major facilitator superfamily
TPB0596_RS17255	COG1609	Transcriptional regulator
TPB0596_RS17265	COG1940	carbohydrate kinase activity
TPB0596_RS17270	COG0058	SHG alpha-glucan phosphorylase activity
TPB0596_RS17275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TPB0596_RS17305	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS17315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TPB0596_RS17340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TPB0596_RS17370	COG0709	Synthesizes selenophosphate from selenide and ATP
TPB0596_RS17380	COG0437	4 iron, 4 sulfur cluster binding
TPB0596_RS17395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TPB0596_RS17420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TPB0596_RS17470	COG0456	acetyltransferase
TPB0596_RS17485	COG2832	Protein of unknown function (DUF454)
TPB0596_RS17510	COG0604	alcohol dehydrogenase
TPB0596_RS17525	COG2814	Major facilitator Superfamily
TPB0596_RS17540	COG1063	alcohol dehydrogenase
TPB0596_RS17575	COG0012	GTP binding
TPB0596_RS17585	COG1172	Belongs to the binding-protein-dependent transport system permease family
TPB0596_RS17595	COG1966	Carbon starvation protein
TPB0596_RS17610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TPB0596_RS17610	COG2169	Transcriptional regulator
TPB0596_RS17615	COG0628	permease
TPB0596_RS17620	COG1322	Protein conserved in bacteria
TPB0596_RS17645	COG1570	exodeoxyribonuclease VII activity
TPB0596_RS17685	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TPB0596_RS17685	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TPB0596_RS17710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TPB0596_RS17720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TPB0596_RS17750	COG1116	anion transmembrane transporter activity
TPB0596_RS17755	COG4521	taurine ABC transporter
TPB0596_RS17760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TPB0596_RS17775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TPB0596_RS17780	COG1331	Highly conserved protein containing a thioredoxin domain
TPB0596_RS17790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TPB0596_RS17800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TPB0596_RS17815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TPB0596_RS17840	COG2755	lipolytic protein G-D-S-L family
TPB0596_RS17885	COG0668	transmembrane transport
TPB0596_RS17920	COG0148	phosphopyruvate hydratase activity
TPB0596_RS17940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPB0596_RS17945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPB0596_RS17965	COG1034	ATP synthesis coupled electron transport
TPB0596_RS17970	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TPB0596_RS17975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPB0596_RS17985	COG0713	ATP synthesis coupled electron transport
TPB0596_RS18030	COG3956	TIGRFAM MazG family protein
TPB0596_RS18040	COG0789	Transcriptional regulator
TPB0596_RS18075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TPB0596_RS18090	COG1393	Belongs to the ArsC family
TPB0596_RS18115	COG2837	iron assimilation
TPB0596_RS18125	COG0542	response to heat
TPB0596_RS18155	COG0193	aminoacyl-tRNA hydrolase activity
TPB0596_RS18160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TPB0596_RS18165	COG1250	3-hydroxyacyl-CoA dehydrogenase
TPB0596_RS18185	COG1280	lysine exporter protein (LysE YggA)
TPB0596_RS18205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TPB0596_RS18225	COG1404	Belongs to the peptidase S8 family
TPB0596_RS18295	COG0101	tRNA pseudouridine synthase activity
TPB0596_RS18315	COG0203	ribosomal protein L17
TPB0596_RS18320	COG0202	RNA polymerase activity
TPB0596_RS18325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TPB0596_RS18330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TPB0596_RS18335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TPB0596_RS18340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TPB0596_RS18350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TPB0596_RS18355	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TPB0596_RS18370	COG0789	Transcriptional regulator
TPB0596_RS18380	COG0563	adenylate kinase activity
TPB0596_RS18390	COG0200	Binds to the 23S rRNA
TPB0596_RS18395	COG1841	ribosomal large subunit assembly
TPB0596_RS18405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TPB0596_RS18410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TPB0596_RS18415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TPB0596_RS18450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TPB0596_RS18455	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TPB0596_RS18460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TPB0596_RS18465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TPB0596_RS18510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TPB0596_RS18515	COG0255	Belongs to the universal ribosomal protein uL29 family
TPB0596_RS18520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TPB0596_RS18525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TPB0596_RS18535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TPB0596_RS18540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TPB0596_RS18545	COG0089	rRNA binding
TPB0596_RS18550	COG0088	Forms part of the polypeptide exit tunnel
TPB0596_RS18555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TPB0596_RS18560	COG0051	transcription antitermination factor activity, RNA binding
TPB0596_RS18585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TPB0596_RS18645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TPB0596_RS18650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPB0596_RS18655	COG0049	tRNA binding
TPB0596_RS18660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TPB0596_RS18690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TPB0596_RS18705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TPB0596_RS18710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TPB0596_RS18725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TPB0596_RS18735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TPB0596_RS18770	COG1131	(ABC) transporter
TPB0596_RS18820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TPB0596_RS18860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TPB0596_RS18860	COG3321	synthase
TPB0596_RS18870	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS18875	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
TPB0596_RS18895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TPB0596_RS18905	COG2072	flavoprotein involved in K transport
TPB0596_RS18920	COG0657	acetylesterase activity
TPB0596_RS18925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TPB0596_RS18930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TPB0596_RS18965	COG2072	flavoprotein involved in K transport
TPB0596_RS18975	COG1595	DNA-templated transcription, initiation
TPB0596_RS19005	COG0438	transferase activity, transferring glycosyl groups
TPB0596_RS19010	COG3842	ATPase activity
TPB0596_RS19015	COG1653	transport
TPB0596_RS19025	COG1175	transmembrane transport
TPB0596_RS19050	COG2197	response regulator
TPB0596_RS19075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TPB0596_RS19095	COG0456	acetyltransferase
TPB0596_RS19100	COG0745	RESPONSE REGULATOR receiver
TPB0596_RS19110	COG2897	thiosulfate sulfurtransferase activity
TPB0596_RS19120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TPB0596_RS19130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TPB0596_RS19150	COG0477	Major facilitator Superfamily
TPB0596_RS19160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TPB0596_RS19185	COG4044	May play a role in the intracellular transport of hydrophobic ligands
TPB0596_RS19210	COG0300	oxidoreductase activity
TPB0596_RS19215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TPB0596_RS19220	COG4988	ABC transporter
TPB0596_RS19225	COG1294	oxidase, subunit
TPB0596_RS19230	COG1271	oxidase subunit
TPB0596_RS19240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TPB0596_RS19245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TPB0596_RS19260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TPB0596_RS19305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TPB0596_RS19325	COG5343	regulation of RNA biosynthetic process
TPB0596_RS19340	COG3706	GGDEF domain
TPB0596_RS19345	COG1113	amino acid transport
TPB0596_RS19385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TPB0596_RS19390	COG1301	dicarboxylic acid transport
TPB0596_RS19400	COG4565	transcriptional regulatory protein
TPB0596_RS19405	COG0300	oxidoreductase activity
TPB0596_RS19415	COG3938	Belongs to the proline racemase family
TPB0596_RS19420	COG1063	alcohol dehydrogenase
TPB0596_RS19425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TPB0596_RS19430	COG1113	amino acid transport
TPB0596_RS19435	COG1362	aminopeptidase activity
TPB0596_RS19440	COG0047	phosphoribosylformylglycinamidine synthase activity
TPB0596_RS19445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TPB0596_RS19460	COG0386	Belongs to the glutathione peroxidase family
TPB0596_RS19470	COG0477	Major facilitator Superfamily
TPB0596_RS19485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TPB0596_RS19495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TPB0596_RS19525	COG2205	protein histidine kinase activity
TPB0596_RS19530	COG0745	RESPONSE REGULATOR receiver
TPB0596_RS19545	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TPB0596_RS19575	COG5002	protein histidine kinase activity
TPB0596_RS19580	COG0745	RESPONSE REGULATOR receiver
TPB0596_RS19625	COG1024	Enoyl-CoA hydratase
TPB0596_RS19655	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TPB0596_RS19665	COG1305	Transglutaminase-like
TPB0596_RS19675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TPB0596_RS19710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TPB0596_RS19715	COG0788	formyltetrahydrofolate deformylase activity
TPB0596_RS19740	COG2733	membrane
TPB0596_RS19745	COG2326	polyphosphate kinase activity
TPB0596_RS19755	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS19760	COG0583	DNA-binding transcription factor activity
TPB0596_RS19790	COG2226	methyltransferase
TPB0596_RS19795	COG0492	ferredoxin-NADP+ reductase activity
TPB0596_RS19805	COG2224	Isocitrate lyase
TPB0596_RS19825	COG5285	phytanoyl-CoA dioxygenase
TPB0596_RS19835	COG1505	serine-type exopeptidase activity
TPB0596_RS19875	COG2326	polyphosphate kinase activity
TPB0596_RS19890	COG3433	isochorismatase activity
TPB0596_RS19890	COG1535	isochorismatase
TPB0596_RS19895	COG1021	2,3-dihydroxybenzoate-AMP ligase
TPB0596_RS19900	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS19910	COG1132	(ABC) transporter
TPB0596_RS19915	COG1132	(ABC) transporter
TPB0596_RS19920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TPB0596_RS19925	COG3486	L-lysine 6-monooxygenase (NADPH) activity
TPB0596_RS19930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TPB0596_RS19935	COG4607	ABC-type enterochelin transport system periplasmic component
TPB0596_RS19945	COG1535	isochorismatase
TPB0596_RS19945	COG3433	isochorismatase activity
TPB0596_RS19995	COG0326	Molecular chaperone. Has ATPase activity
TPB0596_RS20030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TPB0596_RS20055	COG0688	phosphatidylethanolamine metabolic process
TPB0596_RS20065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPB0596_RS20080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TPB0596_RS20080	COG2111	Na H antiporter
TPB0596_RS20090	COG0651	ATP synthesis coupled electron transport
TPB0596_RS20105	COG1320	monovalent cation:proton antiporter activity
TPB0596_RS20135	COG1120	ATPase activity
TPB0596_RS20140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPB0596_RS20185	COG4555	ABC transporter
TPB0596_RS20195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TPB0596_RS20200	COG0351	phosphomethylpyrimidine kinase
TPB0596_RS20210	COG0351	phosphomethylpyrimidine kinase
TPB0596_RS20245	COG0477	Major facilitator Superfamily
TPB0596_RS20255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TPB0596_RS20260	COG2022	thiamine diphosphate biosynthetic process
TPB0596_RS20270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TPB0596_RS20270	COG2022	thiamine diphosphate biosynthetic process
TPB0596_RS20275	COG0352	thiamine-phosphate diphosphorylase activity
TPB0596_RS20290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TPB0596_RS20295	COG0515	serine threonine protein kinase
TPB0596_RS20300	COG1120	ATPase activity
TPB0596_RS20305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPB0596_RS20310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPB0596_RS20325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TPB0596_RS20335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS20345	COG1132	(ABC) transporter
TPB0596_RS20375	COG0657	acetylesterase activity
TPB0596_RS20390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TPB0596_RS20410	COG4941	Belongs to the sigma-70 factor family
TPB0596_RS20420	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TPB0596_RS20430	COG1309	transcriptional regulator
TPB0596_RS20435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPB0596_RS20440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPB0596_RS20475	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS20480	COG3971	2-oxopent-4-enoate hydratase activity
TPB0596_RS20500	COG1414	Transcriptional regulator
TPB0596_RS20520	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS20525	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS20530	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TPB0596_RS20535	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS20560	COG1012	belongs to the aldehyde dehydrogenase family
TPB0596_RS20565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TPB0596_RS20580	COG2070	2-Nitropropane dioxygenase
TPB0596_RS20590	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS20620	COG2124	cytochrome p450
TPB0596_RS20625	COG0183	Belongs to the thiolase family
TPB0596_RS20630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TPB0596_RS20635	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS20645	COG1024	Enoyl-CoA hydratase
TPB0596_RS20670	COG0183	Belongs to the thiolase family
TPB0596_RS20675	COG1309	transcriptional regulator
TPB0596_RS20685	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS20690	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS20695	COG1024	Enoyl-CoA hydratase
TPB0596_RS20700	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS20705	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS20710	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS20725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TPB0596_RS20730	COG0346	lactoylglutathione lyase activity
TPB0596_RS20735	COG2267	carboxylic ester hydrolase activity
TPB0596_RS20740	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS20745	COG1053	succinate dehydrogenase
TPB0596_RS20745	COG3976	FMN-binding domain protein
TPB0596_RS20755	COG1053	succinate dehydrogenase
TPB0596_RS20760	COG4638	Rieske (2fe-2S)
TPB0596_RS20775	COG2030	dehydratase
TPB0596_RS20790	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS20835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPB0596_RS20955	COG2508	Transcriptional regulator
TPB0596_RS20960	COG2072	flavoprotein involved in K transport
TPB0596_RS20970	COG0470	DNA polymerase III
TPB0596_RS20980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TPB0596_RS20980	COG1754	DNA topoisomerase type I activity
TPB0596_RS20990	COG1278	Cold shock
TPB0596_RS20995	COG1111	helicase
TPB0596_RS20995	COG1205	dead DEAH box helicase
TPB0596_RS21125	COG4172	Belongs to the ABC transporter superfamily
TPB0596_RS21130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPB0596_RS21135	COG0601	transmembrane transport
TPB0596_RS21145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TPB0596_RS21150	COG0583	DNA-binding transcription factor activity
TPB0596_RS21160	COG0156	8-amino-7-oxononanoate synthase activity
TPB0596_RS21165	COG2814	Major facilitator Superfamily
TPB0596_RS21170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TPB0596_RS21185	COG1131	(ABC) transporter
TPB0596_RS21205	COG0477	Major facilitator Superfamily
TPB0596_RS21210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TPB0596_RS21220	COG0596	Alpha beta hydrolase
TPB0596_RS21230	COG0494	nUDIX hydrolase
TPB0596_RS21255	COG2828	Protein conserved in bacteria
TPB0596_RS21260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TPB0596_RS21290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TPB0596_RS21300	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS21340	COG1396	sequence-specific DNA binding
TPB0596_RS21350	COG2814	Major facilitator Superfamily
TPB0596_RS21380	COG1408	metallophosphoesterase
TPB0596_RS21395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TPB0596_RS21400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TPB0596_RS21405	COG1764	response to oxidative stress
TPB0596_RS21430	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS21440	COG0583	DNA-binding transcription factor activity
TPB0596_RS21450	COG0768	penicillin binding
TPB0596_RS21465	COG0135	phosphoribosylanthranilate isomerase activity
TPB0596_RS21480	COG1528	Iron-storage protein
TPB0596_RS21485	COG1309	transcriptional regulator
TPB0596_RS21515	COG3251	PFAM MbtH domain protein
TPB0596_RS21525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TPB0596_RS21535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TPB0596_RS21540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TPB0596_RS21540	COG1017	nitric oxide dioxygenase activity
TPB0596_RS21545	COG1959	2 iron, 2 sulfur cluster binding
TPB0596_RS21555	COG4221	oxidoreductase activity
TPB0596_RS21565	COG2807	transmembrane transport
TPB0596_RS21585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TPB0596_RS21620	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPB0596_RS21625	COG0564	pseudouridine synthase activity
TPB0596_RS21640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TPB0596_RS21660	COG1785	Belongs to the alkaline phosphatase family
TPB0596_RS21675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TPB0596_RS21720	COG0596	Alpha beta hydrolase
TPB0596_RS21740	COG3391	amine dehydrogenase activity
TPB0596_RS21740	COG5651	PPE family
TPB0596_RS21750	COG0640	Transcriptional regulator
TPB0596_RS21765	COG1793	dna ligase
TPB0596_RS21770	COG2318	DinB family
TPB0596_RS21780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TPB0596_RS21795	COG0343	queuine tRNA-ribosyltransferase activity
TPB0596_RS21835	COG0287	Prephenate dehydrogenase
TPB0596_RS21885	COG0739	heme binding
TPB0596_RS21895	COG2197	response regulator
TPB0596_RS21990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TPB0596_RS22010	COG4977	sequence-specific DNA binding
TPB0596_RS22030	COG2030	dehydratase
TPB0596_RS22050	COG0385	Bile acid
TPB0596_RS22065	COG1024	Enoyl-CoA hydratase
TPB0596_RS22070	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS22080	COG1309	transcriptional regulator
TPB0596_RS22095	COG0596	Alpha beta hydrolase
TPB0596_RS22140	COG0183	Belongs to the thiolase family
TPB0596_RS22145	COG3321	synthase
TPB0596_RS22145	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS22145	COG0604	alcohol dehydrogenase
TPB0596_RS22180	COG1216	Glycosyl transferase, family 2
TPB0596_RS22185	COG0318	PFAM AMP-dependent synthetase and ligase
TPB0596_RS22215	COG1476	TRANSCRIPTIONal
TPB0596_RS22225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TPB0596_RS22230	COG1012	belongs to the aldehyde dehydrogenase family
TPB0596_RS22235	COG0006	proline dipeptidase activity
TPB0596_RS22240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TPB0596_RS22245	COG1473	amidohydrolase
TPB0596_RS22255	COG1960	acyl-CoA dehydrogenase activity
TPB0596_RS22260	COG1309	transcriptional regulator
TPB0596_RS22270	COG1028	Short-chain dehydrogenase reductase Sdr
TPB0596_RS22290	COG4221	oxidoreductase activity
TPB0596_RS22295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TPB0596_RS22310	COG1122	ATPase activity
TPB0596_RS22315	COG1268	BioY protein
TPB0596_RS22325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TPB0596_RS22365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TPB0596_RS22395	COG1174	glycine betaine transport
TPB0596_RS22405	COG1174	glycine betaine transport
TPB0596_RS22410	COG3973	AAA domain
TPB0596_RS22460	COG0477	Major facilitator Superfamily
TPB0596_RS22465	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TPB0596_RS22485	COG2267	carboxylic ester hydrolase activity
TPB0596_RS22490	COG2508	Transcriptional regulator
TPB0596_RS22510	COG3971	2-oxopent-4-enoate hydratase activity
TPB0596_RS22515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TPB0596_RS22520	COG0346	lactoylglutathione lyase activity
TPB0596_RS22560	COG0360	Binds together with S18 to 16S ribosomal RNA
TPB0596_RS22570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TPB0596_RS22625	COG1309	transcriptional regulator
TPB0596_RS22645	COG0183	Belongs to the thiolase family
TPB0596_RS22650	COG1024	Enoyl-CoA hydratase
TPB0596_RS22650	COG1250	3-hydroxyacyl-CoA dehydrogenase
TPB0596_RS22670	COG1024	Enoyl-CoA hydratase
TPB0596_RS22700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TPB0596_RS22715	COG1260	myo-inositol-1-phosphate synthase
TPB0596_RS22780	COG1358	cellular component organization or biogenesis
TPB0596_RS22795	COG1297	OPT oligopeptide transporter protein
TPB0596_RS22815	COG2814	Major facilitator Superfamily
TPB0596_RS22820	COG0569	domain protein
TPB0596_RS22825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TPB0596_RS22830	COG4221	oxidoreductase activity
TPB0596_RS22835	COG4122	O-methyltransferase activity
TPB0596_RS22865	COG0495	leucyl-tRNA aminoacylation
TPB0596_RS22915	COG0617	tRNA 3'-terminal CCA addition
TPB0596_RS22940	COG0519	Catalyzes the synthesis of GMP from XMP
TPB0596_RS22945	COG1012	belongs to the aldehyde dehydrogenase family
TPB0596_RS23060	COG0860	N-Acetylmuramoyl-L-alanine amidase
TPB0596_RS23060	COG3409	Peptidoglycan-binding domain 1 protein
TPB0596_RS23075	COG1192	Involved in chromosome partitioning
TPB0596_RS23080	COG0357	Ribosomal RNA small subunit methyltransferase G
TPB0596_RS23090	COG0706	membrane insertase activity
TPB0596_RS23095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TPB0596_RS23100	COG0594	ribonuclease P activity