locus-tag	class	description
MTP03_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MTP03_RS00020	COG0592	DNA-directed DNA polymerase activity
MTP03_RS00025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MTP03_RS00035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MTP03_RS00055	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MTP03_RS00060	COG0187	DNA topoisomerase II activity
MTP03_RS00065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MTP03_RS00085	COG4974	Belongs to the 'phage' integrase family
MTP03_RS00140	COG3634	alkyl hydroperoxide reductase activity
MTP03_RS00180	COG2815	serine threonine protein kinase
MTP03_RS00180	COG0515	serine threonine protein kinase
MTP03_RS00195	COG0768	penicillin binding
MTP03_RS00210	COG1716	ATPase activity
MTP03_RS00215	COG1716	ATPase activity
MTP03_RS00245	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS00265	COG1309	transcriptional regulator
MTP03_RS00270	COG3547	Transposase (IS116 IS110 IS902 family)
MTP03_RS00310	COG1073	alpha beta
MTP03_RS00335	COG3336	cytochrome c oxidase
MTP03_RS00345	COG0657	acetylesterase activity
MTP03_RS00365	COG0778	Nitroreductase
MTP03_RS00370	COG1376	ErfK ybiS ycfS ynhG family protein
MTP03_RS00380	COG0640	Transcriptional regulator
MTP03_RS00395	COG0745	RESPONSE REGULATOR receiver
MTP03_RS00400	COG2205	protein histidine kinase activity
MTP03_RS00405	COG5002	protein histidine kinase activity
MTP03_RS00415	COG3559	Exporter of polyketide antibiotics
MTP03_RS00420	COG1131	(ABC) transporter
MTP03_RS00455	COG0070	glutamate synthase
MTP03_RS00455	COG0067	glutamate synthase
MTP03_RS00455	COG0069	glutamate synthase activity
MTP03_RS00475	COG2501	S4 domain
MTP03_RS00485	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS00600	COG1316	TRANSCRIPTIONal
MTP03_RS00610	COG2252	PERMEase
MTP03_RS00620	COG3226	Transcriptional regulator
MTP03_RS00685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MTP03_RS00710	COG0561	phosphatase activity
MTP03_RS00715	COG2385	sporulation resulting in formation of a cellular spore
MTP03_RS00725	COG1216	Glycosyl transferase, family 2
MTP03_RS00730	COG0671	phosphoesterase, PA-phosphatase related
MTP03_RS00735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MTP03_RS00740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MTP03_RS00765	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
MTP03_RS00775	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
MTP03_RS00780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP03_RS00795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTP03_RS00800	COG0277	FAD linked oxidase domain protein
MTP03_RS00825	COG1956	GAF domain-containing protein
MTP03_RS00860	COG1349	DNA-binding transcription factor activity
MTP03_RS00910	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MTP03_RS00955	COG1846	Transcriptional regulator
MTP03_RS01005	COG1396	sequence-specific DNA binding
MTP03_RS01010	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MTP03_RS01015	COG1760	l-serine dehydratase
MTP03_RS01030	COG3214	Protein conserved in bacteria
MTP03_RS01040	COG0659	secondary active sulfate transmembrane transporter activity
MTP03_RS01050	COG0488	(ABC) transporter
MTP03_RS01075	COG0778	Nitroreductase
MTP03_RS01085	COG1309	transcriptional regulator
MTP03_RS01155	COG1309	transcriptional regulator
MTP03_RS01180	COG2409	Drug exporters of the RND superfamily
MTP03_RS01190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MTP03_RS01220	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MTP03_RS01230	COG1476	TRANSCRIPTIONal
MTP03_RS01250	COG1454	alcohol dehydrogenase
MTP03_RS01340	COG1136	(ABC) transporter
MTP03_RS01340	COG0577	efflux transmembrane transporter activity
MTP03_RS01370	COG0492	ferredoxin-NADP+ reductase activity
MTP03_RS01430	COG4981	capsule polysaccharide biosynthetic process
MTP03_RS01435	COG4981	capsule polysaccharide biosynthetic process
MTP03_RS01455	COG1472	Belongs to the glycosyl hydrolase 3 family
MTP03_RS01460	COG1309	transcriptional regulator
MTP03_RS01465	COG2030	dehydratase
MTP03_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS01475	COG0183	Belongs to the thiolase family
MTP03_RS01480	COG1832	CoA-binding protein
MTP03_RS01505	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS01525	COG0477	Major facilitator Superfamily
MTP03_RS01535	COG1115	amino acid carrier protein
MTP03_RS01545	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS01555	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MTP03_RS01555	COG2066	Belongs to the glutaminase family
MTP03_RS01560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MTP03_RS01570	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MTP03_RS01655	COG0708	Exodeoxyribonuclease III
MTP03_RS01705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MTP03_RS01735	COG1454	alcohol dehydrogenase
MTP03_RS01750	COG0145	ligase activity
MTP03_RS01770	COG0179	Fumarylacetoacetate (FAA) hydrolase
MTP03_RS01780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MTP03_RS01795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MTP03_RS01800	COG0484	heat shock protein binding
MTP03_RS01845	COG0542	response to heat
MTP03_RS01850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MTP03_RS01850	COG0493	'glutamate synthase
MTP03_RS01860	COG2267	carboxylic ester hydrolase activity
MTP03_RS01875	COG2149	membrane
MTP03_RS01895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MTP03_RS01910	COG0586	Pfam SNARE associated Golgi protein
MTP03_RS01925	COG0025	NhaP-type Na H and K H
MTP03_RS01990	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MTP03_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS02045	COG3226	Transcriptional regulator
MTP03_RS02070	COG0442	prolyl-tRNA aminoacylation
MTP03_RS02080	COG0343	queuine tRNA-ribosyltransferase activity
MTP03_RS02095	COG2027	D-alanyl-D-alanine carboxypeptidase
MTP03_RS02110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MTP03_RS02125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MTP03_RS02130	COG0302	gtp cyclohydrolase
MTP03_RS02135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MTP03_RS02140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MTP03_RS02165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MTP03_RS02170	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MTP03_RS02175	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MTP03_RS02185	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MTP03_RS02200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MTP03_RS02215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MTP03_RS02305	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MTP03_RS02325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MTP03_RS02335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MTP03_RS02340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MTP03_RS02345	COG1116	anion transmembrane transporter activity
MTP03_RS02375	COG0438	transferase activity, transferring glycosyl groups
MTP03_RS02390	COG0477	Major facilitator Superfamily
MTP03_RS02415	COG0477	Major facilitator Superfamily
MTP03_RS02425	COG0640	Transcriptional regulator
MTP03_RS02435	COG0667	Aldo Keto reductase
MTP03_RS02440	COG0789	Transcriptional regulator
MTP03_RS02465	COG4106	trans-aconitate 2-methyltransferase activity
MTP03_RS02470	COG0583	DNA-binding transcription factor activity
MTP03_RS02475	COG2814	Major facilitator Superfamily
MTP03_RS02480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP03_RS02500	COG0588	phosphoglycerate mutase activity
MTP03_RS02510	COG5002	protein histidine kinase activity
MTP03_RS02515	COG0745	RESPONSE REGULATOR receiver
MTP03_RS02545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MTP03_RS02580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MTP03_RS02585	COG0181	hydroxymethylbilane synthase activity
MTP03_RS02630	COG2608	mercury ion transmembrane transporter activity
MTP03_RS02635	COG2954	triphosphatase activity
MTP03_RS02640	COG2409	Drug exporters of the RND superfamily
MTP03_RS02670	COG3540	Alkaline phosphatase
MTP03_RS02680	COG2272	Belongs to the type-B carboxylesterase lipase family
MTP03_RS02700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MTP03_RS02705	COG0406	alpha-ribazole phosphatase activity
MTP03_RS02715	COG0785	Cytochrome C biogenesis protein
MTP03_RS02725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MTP03_RS02740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MTP03_RS02750	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS02815	COG4948	Mandelate Racemase Muconate Lactonizing
MTP03_RS02830	COG1309	transcriptional regulator
MTP03_RS02835	COG0154	amidase activity
MTP03_RS02850	COG1937	Protein conserved in bacteria
MTP03_RS02855	COG3268	Saccharopine dehydrogenase
MTP03_RS02870	COG3180	Ammonia monooxygenase
MTP03_RS02890	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MTP03_RS02915	COG0142	geranyltranstransferase activity
MTP03_RS02920	COG0501	Belongs to the peptidase M48B family
MTP03_RS02930	COG1666	GTP binding
MTP03_RS02955	COG2030	dehydratase
MTP03_RS02960	COG2030	dehydratase
MTP03_RS02970	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MTP03_RS02980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MTP03_RS02985	COG0081	regulation of translation
MTP03_RS03055	COG3304	Inner membrane component domain
MTP03_RS03090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MTP03_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS03160	COG2508	Transcriptional regulator
MTP03_RS03180	COG3547	Transposase (IS116 IS110 IS902 family)
MTP03_RS03190	COG1073	alpha beta
MTP03_RS03195	COG0778	Nitroreductase
MTP03_RS03215	COG2301	Belongs to the HpcH HpaI aldolase family
MTP03_RS03230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTP03_RS03235	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS03240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MTP03_RS03265	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS03275	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MTP03_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS03305	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS03310	COG1063	alcohol dehydrogenase
MTP03_RS03325	COG0145	ligase activity
MTP03_RS03350	COG1063	alcohol dehydrogenase
MTP03_RS03425	COG2301	Belongs to the HpcH HpaI aldolase family
MTP03_RS03460	COG0765	amino acid transport
MTP03_RS03465	COG1126	abc transporter atp-binding protein
MTP03_RS03470	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MTP03_RS03475	COG1263	PTS System
MTP03_RS03480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTP03_RS03485	COG2190	(PTS) system
MTP03_RS03485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTP03_RS03485	COG1263	PTS System
MTP03_RS03500	COG2188	Transcriptional regulator
MTP03_RS03510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP03_RS03560	COG1061	Type III restriction enzyme res subunit
MTP03_RS03585	COG4941	Belongs to the sigma-70 factor family
MTP03_RS03675	COG0671	phosphoesterase, PA-phosphatase related
MTP03_RS03720	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MTP03_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS03765	COG0545	Peptidyl-prolyl cis-trans isomerase
MTP03_RS03795	COG2319	Wd-40 repeat
MTP03_RS03795	COG4249	Peptidase C14 caspase catalytic subunit p20
MTP03_RS03850	COG1408	metallophosphoesterase
MTP03_RS03855	COG1408	metallophosphoesterase
MTP03_RS03865	COG0328	RNA-DNA hybrid ribonuclease activity
MTP03_RS03895	COG1218	3'(2'),5'-bisphosphate nucleotidase
MTP03_RS03905	COG2259	Doxx family
MTP03_RS03910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP03_RS03920	COG2364	Membrane
MTP03_RS03935	COG0166	Belongs to the GPI family
MTP03_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS04010	COG0739	heme binding
MTP03_RS04025	COG1285	pathogenesis
MTP03_RS04035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTP03_RS04045	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS04060	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS04065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTP03_RS04115	COG0045	succinate-CoA ligase (ADP-forming) activity
MTP03_RS04150	COG0640	Transcriptional regulator
MTP03_RS04165	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MTP03_RS04190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MTP03_RS04195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MTP03_RS04215	COG0254	rRNA binding
MTP03_RS04225	COG2860	membrane
MTP03_RS04250	COG0521	Mo-molybdopterin cofactor biosynthetic process
MTP03_RS04290	COG1970	mechanosensitive ion channel activity
MTP03_RS04325	COG1309	transcriptional regulator
MTP03_RS04335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MTP03_RS04340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MTP03_RS04350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MTP03_RS04365	COG1733	regulation of RNA biosynthetic process
MTP03_RS04370	COG2259	Doxx family
MTP03_RS04385	COG5473	translation initiation factor activity
MTP03_RS04410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MTP03_RS04450	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MTP03_RS04465	COG0477	Major facilitator Superfamily
MTP03_RS04510	COG0084	hydrolase, TatD family'
MTP03_RS04525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MTP03_RS04560	COG0574	Belongs to the PEP-utilizing enzyme family
MTP03_RS04560	COG3848	Pyruvate phosphate dikinase
MTP03_RS04565	COG3848	Pyruvate phosphate dikinase
MTP03_RS04565	COG0574	Belongs to the PEP-utilizing enzyme family
MTP03_RS04570	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS04580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MTP03_RS04620	COG1280	lysine exporter protein (LysE YggA)
MTP03_RS04625	COG3547	Transposase (IS116 IS110 IS902 family)
MTP03_RS04655	COG0193	aminoacyl-tRNA hydrolase activity
MTP03_RS04725	COG1393	Belongs to the ArsC family
MTP03_RS04775	COG0789	Transcriptional regulator
MTP03_RS04785	COG3956	TIGRFAM MazG family protein
MTP03_RS04810	COG1073	alpha beta
MTP03_RS04875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MTP03_RS04900	COG0148	phosphopyruvate hydratase activity
MTP03_RS05010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MTP03_RS05025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MTP03_RS05040	COG3177	Filamentation induced by cAMP protein fic
MTP03_RS05085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MTP03_RS05090	COG4521	taurine ABC transporter
MTP03_RS05095	COG1116	anion transmembrane transporter activity
MTP03_RS05115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MTP03_RS05125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MTP03_RS05140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MTP03_RS05140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MTP03_RS05180	COG1570	exodeoxyribonuclease VII activity
MTP03_RS05210	COG1322	Protein conserved in bacteria
MTP03_RS05215	COG0628	permease
MTP03_RS05220	COG2169	Transcriptional regulator
MTP03_RS05220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MTP03_RS05235	COG1966	Carbon starvation protein
MTP03_RS05240	COG0012	GTP binding
MTP03_RS05285	COG2824	Alkylphosphonate utilization operon protein PhnA
MTP03_RS05310	COG2814	Major facilitator Superfamily
MTP03_RS05340	COG0604	alcohol dehydrogenase
MTP03_RS05365	COG2832	Protein of unknown function (DUF454)
MTP03_RS05380	COG1846	Transcriptional regulator
MTP03_RS05460	COG0437	4 iron, 4 sulfur cluster binding
MTP03_RS05470	COG0709	Synthesizes selenophosphate from selenide and ATP
MTP03_RS05500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTP03_RS05530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MTP03_RS05535	COG1940	carbohydrate kinase activity
MTP03_RS05545	COG1940	carbohydrate kinase activity
MTP03_RS05560	COG1609	Transcriptional regulator
MTP03_RS05570	COG0738	Major facilitator superfamily
MTP03_RS05580	COG1051	belongs to the nudix hydrolase family
MTP03_RS05600	COG3842	ATPase activity
MTP03_RS05605	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MTP03_RS05630	COG1252	NADH dehydrogenase
MTP03_RS05645	COG0747	negative chemotaxis
MTP03_RS05660	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MTP03_RS05665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MTP03_RS05680	COG3220	belongs to the UPF0276 family
MTP03_RS05695	COG2239	Acts as a magnesium transporter
MTP03_RS05710	COG1611	Belongs to the LOG family
MTP03_RS05715	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS05720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MTP03_RS05780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MTP03_RS05795	COG1073	alpha beta
MTP03_RS05795	COG2226	methyltransferase
MTP03_RS05800	COG0300	oxidoreductase activity
MTP03_RS05815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MTP03_RS05855	COG1132	(ABC) transporter
MTP03_RS05860	COG0531	amino acid
MTP03_RS05865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MTP03_RS05880	COG2239	Acts as a magnesium transporter
MTP03_RS05950	COG0598	Magnesium transport protein CorA
MTP03_RS05965	COG1309	transcriptional regulator
MTP03_RS05970	COG0508	dehydrogenase complex catalyzes the overall conversion of
MTP03_RS05970	COG0567	Dehydrogenase, E1 component
MTP03_RS06000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MTP03_RS06020	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS06030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MTP03_RS06060	COG0018	arginyl-trna synthetase
MTP03_RS06070	COG0460	homoserine dehydrogenase
MTP03_RS06075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MTP03_RS06080	COG0083	homoserine kinase activity
MTP03_RS06100	COG0254	rRNA binding
MTP03_RS06105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MTP03_RS06110	COG2890	protein-(glutamine-N5) methyltransferase activity
MTP03_RS06165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MTP03_RS06170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MTP03_RS06175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MTP03_RS06190	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MTP03_RS06205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MTP03_RS06210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MTP03_RS06215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MTP03_RS06220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MTP03_RS06255	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MTP03_RS06290	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS06305	COG0657	acetylesterase activity
MTP03_RS06310	COG1126	abc transporter atp-binding protein
MTP03_RS06315	COG0765	amino acid transport
MTP03_RS06330	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS06335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MTP03_RS06340	COG0657	acetylesterase activity
MTP03_RS06370	COG0579	oxidoreductase
MTP03_RS06385	COG1403	HNH endonuclease
MTP03_RS06390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MTP03_RS06395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MTP03_RS06400	COG0366	Alpha amylase catalytic
MTP03_RS06420	COG1929	Belongs to the glycerate kinase type-1 family
MTP03_RS06435	COG3622	Belongs to the hyi family
MTP03_RS06440	COG2233	PERMEase
MTP03_RS06450	COG2351	hydroxyisourate hydrolase activity
MTP03_RS06480	COG1335	isochorismatase
MTP03_RS06485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MTP03_RS06515	COG0705	Rhomboid family
MTP03_RS06520	COG1234	tRNA 3'-trailer cleavage
MTP03_RS06525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MTP03_RS06535	COG1316	TRANSCRIPTIONal
MTP03_RS06565	COG1022	Amp-dependent synthetase and ligase
MTP03_RS06630	COG0439	Biotin carboxylase
MTP03_RS06645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MTP03_RS06660	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS06685	COG1376	ErfK ybiS ycfS ynhG family protein
MTP03_RS06695	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS06765	COG3402	PFAM membrane-flanked domain
MTP03_RS06795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MTP03_RS06815	COG4941	Belongs to the sigma-70 factor family
MTP03_RS06820	COG3795	YCII-related domain
MTP03_RS06830	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MTP03_RS06845	COG0300	oxidoreductase activity
MTP03_RS06875	COG0477	Major facilitator Superfamily
MTP03_RS06885	COG3618	amidohydrolase
MTP03_RS06895	COG0667	Aldo Keto reductase
MTP03_RS06915	COG0657	acetylesterase activity
MTP03_RS06920	COG2084	Dehydrogenase
MTP03_RS06935	COG0667	Aldo Keto reductase
MTP03_RS06940	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS06945	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS06950	COG0183	Belongs to the thiolase family
MTP03_RS06975	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS06980	COG1024	Enoyl-CoA hydratase
MTP03_RS07005	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTP03_RS07010	COG1250	3-hydroxyacyl-CoA dehydrogenase
MTP03_RS07015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MTP03_RS07020	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS07025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MTP03_RS07030	COG1024	Enoyl-CoA hydratase
MTP03_RS07040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MTP03_RS07075	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS07080	COG0477	Major facilitator Superfamily
MTP03_RS07090	COG1263	PTS System
MTP03_RS07090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTP03_RS07090	COG2190	(PTS) system
MTP03_RS07095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MTP03_RS07095	COG2190	(PTS) system
MTP03_RS07095	COG1263	PTS System
MTP03_RS07100	COG2723	6-phospho-beta-galactosidase activity
MTP03_RS07125	COG2226	methyltransferase
MTP03_RS07130	COG1252	NADH dehydrogenase
MTP03_RS07140	COG1695	Transcriptional regulator
MTP03_RS07240	COG2851	Citrate transporter
MTP03_RS07245	COG3290	protein histidine kinase activity
MTP03_RS07250	COG4565	transcriptional regulatory protein
MTP03_RS07260	COG3177	Filamentation induced by cAMP protein fic
MTP03_RS07270	COG1131	(ABC) transporter
MTP03_RS07310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP03_RS07365	COG2146	nitrite reductase [NAD(P)H] activity
MTP03_RS07365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MTP03_RS07455	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MTP03_RS07465	COG3012	SEC-C Motif Domain Protein
MTP03_RS07480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MTP03_RS07485	COG0501	Belongs to the peptidase M48B family
MTP03_RS07490	COG0698	ribose 5-phosphate isomerase
MTP03_RS07525	COG0477	Major facilitator Superfamily
MTP03_RS07560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MTP03_RS07590	COG2197	response regulator
MTP03_RS07620	COG0531	amino acid
MTP03_RS07640	COG1024	Enoyl-CoA hydratase
MTP03_RS07655	COG0477	Major facilitator Superfamily
MTP03_RS07725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP03_RS07730	COG1120	ATPase activity
MTP03_RS07740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MTP03_RS07760	COG3135	benzoate transporter
MTP03_RS07765	COG0515	serine threonine protein kinase
MTP03_RS07795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MTP03_RS07820	COG0544	peptidyl-prolyl cis-trans isomerase activity
MTP03_RS07840	COG0488	(ABC) transporter
MTP03_RS07855	COG0525	valine-tRNA ligase activity
MTP03_RS07860	COG0285	dihydrofolate synthase activity
MTP03_RS07885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MTP03_RS07895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MTP03_RS07915	COG0740	serine-type endopeptidase activity
MTP03_RS07935	COG1472	Belongs to the glycosyl hydrolase 3 family
MTP03_RS07945	COG0598	Magnesium transport protein CorA
MTP03_RS07955	COG1846	Transcriptional regulator
MTP03_RS08010	COG0477	Major facilitator Superfamily
MTP03_RS08015	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MTP03_RS08030	COG1917	Cupin 2, conserved barrel domain protein
MTP03_RS08040	COG0456	acetyltransferase
MTP03_RS08075	COG0477	Major facilitator Superfamily
MTP03_RS08080	COG0742	ribosomal rna small subunit methyltransferase
MTP03_RS08090	COG3599	regulation of cell shape
MTP03_RS08100	COG0571	ribonuclease III activity
MTP03_RS08125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP03_RS08130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP03_RS08160	COG0754	glutathionylspermidine amidase activity
MTP03_RS08165	COG3766	membrane
MTP03_RS08190	COG0270	DNA (cytosine-5-)-methyltransferase activity
MTP03_RS08195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MTP03_RS08220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MTP03_RS08245	COG0831	urea catabolic process
MTP03_RS08265	COG0830	nickel cation binding
MTP03_RS08275	COG0829	nickel cation binding
MTP03_RS08300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTP03_RS08325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MTP03_RS08350	COG0228	four-way junction DNA binding
MTP03_RS08365	COG0336	Belongs to the RNA methyltransferase TrmD family
MTP03_RS08410	COG0335	large ribosomal subunit rRNA binding
MTP03_RS08415	COG0681	Belongs to the peptidase S26 family
MTP03_RS08420	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MTP03_RS08490	COG2011	ABC-type metal ion transport system permease component
MTP03_RS08505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MTP03_RS08525	COG2814	Major facilitator Superfamily
MTP03_RS08540	COG0443	Heat shock 70 kDa protein
MTP03_RS08550	COG1823	symporter activity
MTP03_RS08570	COG0052	Belongs to the universal ribosomal protein uS2 family
MTP03_RS08575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MTP03_RS08605	COG0233	cytoplasmic translational termination
MTP03_RS08610	COG0575	Belongs to the CDS family
MTP03_RS08625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MTP03_RS08650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MTP03_RS08695	COG0768	penicillin binding
MTP03_RS08765	COG1554	hydrolase, family 65, central catalytic
MTP03_RS08780	COG0477	Major facilitator Superfamily
MTP03_RS08785	COG1940	carbohydrate kinase activity
MTP03_RS08820	COG0442	prolyl-tRNA aminoacylation
MTP03_RS08845	COG0779	Required for maturation of 30S ribosomal subunits
MTP03_RS08870	COG0481	GTPase activity
MTP03_RS08870	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MTP03_RS08880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MTP03_RS08885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MTP03_RS08930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTP03_RS08940	COG2977	Belongs to the P-Pant transferase superfamily
MTP03_RS08945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MTP03_RS08950	COG0372	Belongs to the citrate synthase family
MTP03_RS08970	COG1321	iron dependent repressor
MTP03_RS08980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MTP03_RS08995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MTP03_RS08995	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MTP03_RS09000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MTP03_RS09000	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MTP03_RS09015	COG1185	polyribonucleotide nucleotidyltransferase activity
MTP03_RS09025	COG0584	glycerophosphoryl diester phosphodiesterase
MTP03_RS09040	COG0686	Belongs to the AlaDH PNT family
MTP03_RS09045	COG1522	sequence-specific DNA binding
MTP03_RS09050	COG1063	alcohol dehydrogenase
MTP03_RS09090	COG2409	Drug exporters of the RND superfamily
MTP03_RS09105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MTP03_RS09145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MTP03_RS09155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MTP03_RS09160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MTP03_RS09195	COG2890	protein-(glutamine-N5) methyltransferase activity
MTP03_RS09210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MTP03_RS09220	COG1058	Belongs to the CinA family
MTP03_RS09220	COG1546	Belongs to the CinA family
MTP03_RS09225	COG1396	sequence-specific DNA binding
MTP03_RS09230	COG1842	Phage shock protein A
MTP03_RS09290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MTP03_RS09295	COG2137	regulation of response to DNA damage stimulus
MTP03_RS09305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTP03_RS09310	COG0765	amino acid transport
MTP03_RS09320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTP03_RS09325	COG1126	abc transporter atp-binding protein
MTP03_RS09340	COG1196	nuclear chromosome segregation
MTP03_RS09350	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MTP03_RS09360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MTP03_RS09375	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS09380	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS09400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MTP03_RS09410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MTP03_RS09430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MTP03_RS09435	COG1595	DNA-templated transcription, initiation
MTP03_RS09450	COG0450	alkyl hydroperoxide reductase
MTP03_RS09540	COG2890	protein-(glutamine-N5) methyltransferase activity
MTP03_RS09580	COG3590	peptidase
MTP03_RS09595	COG0183	Belongs to the thiolase family
MTP03_RS09600	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS09605	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS09615	COG1011	Hydrolase
MTP03_RS09640	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS09645	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS09655	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS09680	COG4770	biotin carboxylase activity
MTP03_RS09750	COG0756	dUTP diphosphatase activity
MTP03_RS09780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MTP03_RS09805	COG3253	May function as heme-dependent peroxidase
MTP03_RS09835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MTP03_RS09840	COG1937	Protein conserved in bacteria
MTP03_RS09850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTP03_RS09895	COG0346	lactoylglutathione lyase activity
MTP03_RS09945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MTP03_RS09965	COG0438	transferase activity, transferring glycosyl groups
MTP03_RS09980	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MTP03_RS09995	COG1946	Acyl-CoA thioesterase
MTP03_RS10000	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MTP03_RS10025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MTP03_RS10035	COG2255	four-way junction helicase activity
MTP03_RS10060	COG2175	clavaminate synthase activity
MTP03_RS10065	COG3246	L-lysine catabolic process to acetate
MTP03_RS10130	COG0124	histidyl-tRNA synthetase
MTP03_RS10145	COG0640	Transcriptional regulator
MTP03_RS10170	COG0277	FAD linked oxidase domain protein
MTP03_RS10215	COG0444	Belongs to the ABC transporter superfamily
MTP03_RS10220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTP03_RS10260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MTP03_RS10270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MTP03_RS10310	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS10320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTP03_RS10325	COG1126	abc transporter atp-binding protein
MTP03_RS10330	COG0765	amino acid transport
MTP03_RS10335	COG2197	response regulator
MTP03_RS10365	COG4115	mRNA cleavage
MTP03_RS10370	COG4691	Plasmid stability protein
MTP03_RS10385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP03_RS10390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP03_RS10430	COG0671	phosphoesterase, PA-phosphatase related
MTP03_RS10440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MTP03_RS10455	COG0431	NADPH-dependent FMN reductase
MTP03_RS10475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MTP03_RS10540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MTP03_RS10545	COG1953	Uracil, thiamine, allantoin
MTP03_RS10555	COG1301	dicarboxylic acid transport
MTP03_RS10560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MTP03_RS10575	COG0402	S-adenosylhomocysteine deaminase activity
MTP03_RS10585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MTP03_RS10595	COG2252	PERMEase
MTP03_RS10605	COG2382	esterase
MTP03_RS10615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MTP03_RS10625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MTP03_RS10630	COG0483	inositol monophosphate 1-phosphatase activity
MTP03_RS10640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MTP03_RS10660	COG0134	indole-3-glycerol-phosphate synthase activity
MTP03_RS10665	COG2971	BadF BadG BcrA BcrD
MTP03_RS10670	COG2814	Major facilitator Superfamily
MTP03_RS10675	COG2188	Transcriptional regulator
MTP03_RS10700	COG0488	(ABC) transporter
MTP03_RS10720	COG1819	glycosyl
MTP03_RS10725	COG1309	transcriptional regulator
MTP03_RS10730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MTP03_RS10755	COG3550	peptidyl-serine autophosphorylation
MTP03_RS10765	COG1396	sequence-specific DNA binding
MTP03_RS10870	COG1309	transcriptional regulator
MTP03_RS10885	COG0791	NLP P60 protein
MTP03_RS10885	COG3883	PFAM NLP P60 protein
MTP03_RS10890	COG0714	Associated with various cellular activities
MTP03_RS10910	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MTP03_RS10915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MTP03_RS10960	COG2267	carboxylic ester hydrolase activity
MTP03_RS11025	COG1233	COG1233 Phytoene dehydrogenase and related
MTP03_RS11030	COG2186	Transcriptional regulator
MTP03_RS11065	COG0028	Belongs to the TPP enzyme family
MTP03_RS11095	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS11105	COG3243	poly(R)-hydroxyalkanoic acid synthase
MTP03_RS11110	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MTP03_RS11250	COG0583	DNA-binding transcription factor activity
MTP03_RS11255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MTP03_RS11280	COG3220	belongs to the UPF0276 family
MTP03_RS11300	COG0215	cysteine-tRNA ligase activity
MTP03_RS11330	COG0737	Belongs to the 5'-nucleotidase family
MTP03_RS11335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MTP03_RS11350	COG0140	phosphoribosyl-ATP diphosphatase activity
MTP03_RS11355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MTP03_RS11380	COG0842	Transport permease protein
MTP03_RS11380	COG1131	(ABC) transporter
MTP03_RS11380	COG1716	ATPase activity
MTP03_RS11425	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MTP03_RS11440	COG0733	neurotransmitter:sodium symporter activity
MTP03_RS11475	COG2378	regulation of single-species biofilm formation
MTP03_RS11480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MTP03_RS11510	COG0477	Major facilitator Superfamily
MTP03_RS11550	COG3467	pyridoxamine 5'-phosphate
MTP03_RS11555	COG2814	Major facilitator Superfamily
MTP03_RS11560	COG1396	sequence-specific DNA binding
MTP03_RS11585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MTP03_RS11600	COG2826	transposase and inactivated derivatives, IS30 family
MTP03_RS11625	COG0463	Glycosyl transferase, family 2
MTP03_RS11655	COG1376	ErfK ybiS ycfS ynhG family protein
MTP03_RS11660	COG2072	flavoprotein involved in K transport
MTP03_RS11685	COG1454	alcohol dehydrogenase
MTP03_RS11715	COG2807	transmembrane transport
MTP03_RS11725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MTP03_RS11755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MTP03_RS11765	COG0640	Transcriptional regulator
MTP03_RS11880	COG2267	carboxylic ester hydrolase activity
MTP03_RS12155	COG3795	YCII-related domain
MTP03_RS12175	COG1716	ATPase activity
MTP03_RS12190	COG0653	protein targeting
MTP03_RS12195	COG2234	aminopeptidase activity
MTP03_RS12205	COG0596	Alpha beta hydrolase
MTP03_RS12250	COG2365	Tyrosine phosphatase family
MTP03_RS12285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MTP03_RS12305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MTP03_RS12325	COG0494	nUDIX hydrolase
MTP03_RS12390	COG2094	Belongs to the DNA glycosylase MPG family
MTP03_RS12395	COG2835	tetraacyldisaccharide 4'-kinase activity
MTP03_RS12410	COG1131	(ABC) transporter
MTP03_RS12420	COG1309	transcriptional regulator
MTP03_RS12425	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS12430	COG0165	Argininosuccinate lyase
MTP03_RS12435	COG0137	argininosuccinate synthase activity
MTP03_RS12440	COG1438	arginine binding
MTP03_RS12485	COG3284	Transcriptional regulator
MTP03_RS12495	COG0072	phenylalanine-tRNA ligase activity
MTP03_RS12495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MTP03_RS12525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MTP03_RS12555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MTP03_RS12600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MTP03_RS12610	COG0237	dephospho-CoA kinase activity
MTP03_RS12610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MTP03_RS12625	COG1070	Carbohydrate kinase
MTP03_RS12635	COG1063	alcohol dehydrogenase
MTP03_RS12655	COG0395	ABC-type sugar transport system, permease component
MTP03_RS12660	COG3842	ATPase activity
MTP03_RS12665	COG0539	negative regulation of cytoplasmic translation
MTP03_RS12675	COG4715	Zinc finger, swim domain protein
MTP03_RS12680	COG3552	Protein containing von Willebrand factor type A (VWA) domain
MTP03_RS12695	COG0714	Associated with various cellular activities
MTP03_RS12700	COG0714	Associated with various cellular activities
MTP03_RS12710	COG3831	ATPase activity
MTP03_RS12825	COG4260	virion core protein, lumpy skin disease virus
MTP03_RS12830	COG3422	double-strand break repair
MTP03_RS12850	COG0477	Major facilitator Superfamily
MTP03_RS12860	COG0435	Glutathione S-transferase
MTP03_RS12995	COG1946	Acyl-CoA thioesterase
MTP03_RS13030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MTP03_RS13040	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS13065	COG2188	Transcriptional regulator
MTP03_RS13120	COG1846	Transcriptional regulator
MTP03_RS13125	COG2188	Transcriptional regulator
MTP03_RS13150	COG2151	metal-sulfur cluster biosynthetic enzyme
MTP03_RS13165	COG0396	ATPase activity
MTP03_RS13190	COG1131	(ABC) transporter
MTP03_RS13235	COG0446	pyridine nucleotide-disulphide oxidoreductase
MTP03_RS13235	COG1902	pentaerythritol trinitrate reductase activity
MTP03_RS13240	COG1309	transcriptional regulator
MTP03_RS13255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MTP03_RS13310	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
MTP03_RS13315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MTP03_RS13320	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MTP03_RS13325	COG0149	triose-phosphate isomerase activity
MTP03_RS13330	COG0126	phosphoglycerate kinase activity
MTP03_RS13335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MTP03_RS13345	COG1481	regulation of sporulation
MTP03_RS13370	COG3842	ATPase activity
MTP03_RS13490	COG3104	oligopeptide transport
MTP03_RS13500	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS13520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MTP03_RS13560	COG2826	transposase and inactivated derivatives, IS30 family
MTP03_RS13585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MTP03_RS13615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MTP03_RS13625	COG1758	RNA polymerase activity
MTP03_RS13640	COG0284	orotidine-5'-phosphate decarboxylase activity
MTP03_RS13650	COG0505	Belongs to the CarA family
MTP03_RS13695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MTP03_RS13705	COG0006	proline dipeptidase activity
MTP03_RS13735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MTP03_RS13765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MTP03_RS13770	COG1193	negative regulation of DNA recombination
MTP03_RS13800	COG1090	epimerase
MTP03_RS13815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MTP03_RS13830	COG0252	asparaginase activity
MTP03_RS13840	COG0569	domain protein
MTP03_RS13870	COG1024	Enoyl-CoA hydratase
MTP03_RS13905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MTP03_RS13910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MTP03_RS13915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MTP03_RS13935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MTP03_RS13950	COG0768	penicillin binding
MTP03_RS13965	COG2001	Belongs to the MraZ family
MTP03_RS14000	COG0142	geranyltranstransferase activity
MTP03_RS14005	COG4607	ABC-type enterochelin transport system periplasmic component
MTP03_RS14020	COG4604	ABC transporter, ATP-binding protein
MTP03_RS14060	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MTP03_RS14105	COG0438	transferase activity, transferring glycosyl groups
MTP03_RS14135	COG2301	Belongs to the HpcH HpaI aldolase family
MTP03_RS14140	COG0442	prolyl-tRNA aminoacylation
MTP03_RS14145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MTP03_RS14190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MTP03_RS14200	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS14200	COG3321	synthase
MTP03_RS14200	COG0604	alcohol dehydrogenase
MTP03_RS14220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MTP03_RS14235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MTP03_RS14255	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MTP03_RS14280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MTP03_RS14290	COG2233	PERMEase
MTP03_RS14325	COG0321	lipoyl(octanoyl) transferase activity
MTP03_RS14350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MTP03_RS14365	COG0174	glutamine synthetase
MTP03_RS14395	COG1136	(ABC) transporter
MTP03_RS14400	COG0515	serine threonine protein kinase
MTP03_RS14415	COG0545	Peptidyl-prolyl cis-trans isomerase
MTP03_RS14430	COG0174	glutamine synthetase
MTP03_RS14445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MTP03_RS14445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MTP03_RS14450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MTP03_RS14535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MTP03_RS14585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MTP03_RS14740	COG2226	methyltransferase
MTP03_RS14755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MTP03_RS14780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MTP03_RS14785	COG1278	Cold shock
MTP03_RS14795	COG0423	glycine-tRNA ligase activity
MTP03_RS14815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MTP03_RS14830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MTP03_RS14835	COG1846	Transcriptional regulator
MTP03_RS14880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MTP03_RS14905	COG0484	heat shock protein binding
MTP03_RS14910	COG1420	regulation of RNA biosynthetic process
MTP03_RS14925	COG2968	Membrane
MTP03_RS14940	COG0175	sulfate reduction
MTP03_RS14960	COG0531	amino acid
MTP03_RS14960	COG1674	ftsk spoiiie
MTP03_RS14975	COG4552	Acetyltransferase involved in intracellular survival and related
MTP03_RS14990	COG3842	ATPase activity
MTP03_RS14995	COG4208	sulfate ABC transporter
MTP03_RS15035	COG0339	signal peptide processing
MTP03_RS15050	COG2070	2-Nitropropane dioxygenase
MTP03_RS15065	COG0481	GTPase activity
MTP03_RS15080	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS15120	COG1305	Transglutaminase-like
MTP03_RS15135	COG0268	Binds directly to 16S ribosomal RNA
MTP03_RS15150	COG1596	polysaccharide export
MTP03_RS15150	COG1555	photosystem II stabilization
MTP03_RS15160	COG2755	lipolytic protein G-D-S-L family
MTP03_RS15170	COG0799	negative regulation of ribosome biogenesis
MTP03_RS15175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MTP03_RS15185	COG0542	response to heat
MTP03_RS15195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MTP03_RS15225	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS15230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTP03_RS15250	COG1309	transcriptional regulator
MTP03_RS15270	COG1461	Dihydroxyacetone kinase
MTP03_RS15275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MTP03_RS15295	COG1181	Belongs to the D-alanine--D-alanine ligase family
MTP03_RS15300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MTP03_RS15305	COG1920	GTP binding
MTP03_RS15325	COG0066	3-isopropylmalate dehydratase activity
MTP03_RS15345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MTP03_RS15355	COG1846	Transcriptional regulator
MTP03_RS15400	COG1082	Xylose isomerase domain protein TIM barrel
MTP03_RS15405	COG0673	inositol 2-dehydrogenase activity
MTP03_RS15420	COG3718	enzyme involved in inositol metabolism
MTP03_RS15440	COG2188	Transcriptional regulator
MTP03_RS15455	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS15470	COG0673	inositol 2-dehydrogenase activity
MTP03_RS15475	COG1082	Xylose isomerase domain protein TIM barrel
MTP03_RS15490	COG0673	inositol 2-dehydrogenase activity
MTP03_RS15500	COG1172	Belongs to the binding-protein-dependent transport system permease family
MTP03_RS15525	COG0673	inositol 2-dehydrogenase activity
MTP03_RS15530	COG2814	Major facilitator Superfamily
MTP03_RS15535	COG0589	response to stress
MTP03_RS15540	COG0179	Fumarylacetoacetate (FAA) hydrolase
MTP03_RS15565	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS15595	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MTP03_RS15600	COG0440	acetolactate synthase activity
MTP03_RS15610	COG0129	dihydroxy-acid dehydratase activity
MTP03_RS15635	COG0205	6-phosphofructokinase activity
MTP03_RS15640	COG2197	response regulator
MTP03_RS15645	COG4585	Histidine kinase
MTP03_RS15675	COG1959	2 iron, 2 sulfur cluster binding
MTP03_RS15685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MTP03_RS15695	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS15730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MTP03_RS15760	COG1024	Enoyl-CoA hydratase
MTP03_RS15770	COG1607	acyl-coa hydrolase
MTP03_RS15805	COG2986	histidine ammonia-lyase
MTP03_RS15930	COG2197	response regulator
MTP03_RS15935	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MTP03_RS15945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MTP03_RS15975	COG0110	maltose O-acetyltransferase activity
MTP03_RS15995	COG0024	Methionine aminopeptidase
MTP03_RS16010	COG0436	Aminotransferase
MTP03_RS16020	COG2226	methyltransferase
MTP03_RS16035	COG1119	ATPase activity
MTP03_RS16040	COG1523	belongs to the glycosyl hydrolase 13 family
MTP03_RS16050	COG0560	Phosphoserine phosphatase
MTP03_RS16050	COG3830	Belongs to the UPF0237 family
MTP03_RS16080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MTP03_RS16120	COG2146	nitrite reductase [NAD(P)H] activity
MTP03_RS16145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MTP03_RS16185	COG0523	cobalamin synthesis protein
MTP03_RS16205	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MTP03_RS16215	COG0640	Transcriptional regulator
MTP03_RS16260	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
MTP03_RS16280	COG1309	transcriptional regulator
MTP03_RS16290	COG1024	Enoyl-CoA hydratase
MTP03_RS16295	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS16305	COG2030	dehydratase
MTP03_RS16325	COG2801	Transposase and inactivated derivatives
MTP03_RS16355	COG2610	gluconate transmembrane transporter activity
MTP03_RS16365	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MTP03_RS16420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MTP03_RS16425	COG2177	Part of the ABC transporter FtsEX involved in
MTP03_RS16430	COG2884	Cell division ATP-binding protein ftsE
MTP03_RS16440	COG0668	transmembrane transport
MTP03_RS16445	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MTP03_RS16460	COG0483	inositol monophosphate 1-phosphatase activity
MTP03_RS16465	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS16475	COG1388	LysM domain
MTP03_RS16490	COG0730	response to heat
MTP03_RS16515	COG1615	UPF0182 protein
MTP03_RS16525	COG3480	Lon protease (S16) C-terminal proteolytic domain
MTP03_RS16560	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS16605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MTP03_RS16620	COG0210	DNA helicase
MTP03_RS16630	COG0596	Alpha beta hydrolase
MTP03_RS16680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MTP03_RS16680	COG0596	Alpha beta hydrolase
MTP03_RS16685	COG1309	transcriptional regulator
MTP03_RS16695	COG0513	Belongs to the DEAD box helicase family
MTP03_RS16720	COG1192	Involved in chromosome partitioning
MTP03_RS16755	COG1595	DNA-templated transcription, initiation
MTP03_RS16765	COG2337	Toxic component of a toxin-antitoxin (TA) module
MTP03_RS16795	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS16810	COG2135	peptidase activity
MTP03_RS16825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MTP03_RS16835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MTP03_RS16865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MTP03_RS16870	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MTP03_RS16875	COG1113	amino acid transport
MTP03_RS16935	COG0653	protein targeting
MTP03_RS16940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MTP03_RS16960	COG5401	PFAM Sporulation and spore germination
MTP03_RS16970	COG5002	protein histidine kinase activity
MTP03_RS16975	COG0745	RESPONSE REGULATOR receiver
MTP03_RS17005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MTP03_RS17010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MTP03_RS17020	COG1595	DNA-templated transcription, initiation
MTP03_RS17025	COG4122	O-methyltransferase activity
MTP03_RS17035	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
MTP03_RS17040	COG2755	lipolytic protein G-D-S-L family
MTP03_RS17060	COG1316	TRANSCRIPTIONal
MTP03_RS17100	COG2205	protein histidine kinase activity
MTP03_RS17105	COG0745	RESPONSE REGULATOR receiver
MTP03_RS17135	COG0424	maF-like protein
MTP03_RS17155	COG2755	lipolytic protein G-D-S-L family
MTP03_RS17160	COG0477	Major facilitator Superfamily
MTP03_RS17190	COG4770	biotin carboxylase activity
MTP03_RS17220	COG3360	Dodecin
MTP03_RS17225	COG3547	Transposase (IS116 IS110 IS902 family)
MTP03_RS17250	COG0477	Major facilitator Superfamily
MTP03_RS17260	COG2197	response regulator
MTP03_RS17275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MTP03_RS17280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP03_RS17285	COG0148	phosphopyruvate hydratase activity
MTP03_RS17290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MTP03_RS17300	COG2390	Transcriptional regulator
MTP03_RS17305	COG0205	6-phosphofructokinase activity
MTP03_RS17325	COG1349	DNA-binding transcription factor activity
MTP03_RS17350	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS17360	COG2271	Major facilitator Superfamily
MTP03_RS17370	COG2175	clavaminate synthase activity
MTP03_RS17405	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MTP03_RS17405	COG1473	amidohydrolase
MTP03_RS17425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTP03_RS17460	COG2197	response regulator
MTP03_RS17465	COG4585	Histidine kinase
MTP03_RS17490	COG2009	succinate dehydrogenase
MTP03_RS17505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MTP03_RS17560	COG1686	Belongs to the peptidase S11 family
MTP03_RS17575	COG0180	Tryptophanyl-tRNA synthetase
MTP03_RS17595	COG2814	Major facilitator Superfamily
MTP03_RS17615	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MTP03_RS17680	COG1872	DUF167
MTP03_RS17710	COG0587	DNA-directed DNA polymerase activity
MTP03_RS17715	COG1742	UPF0060 membrane protein
MTP03_RS17795	COG0833	amino acid
MTP03_RS17805	COG2815	serine threonine protein kinase
MTP03_RS17805	COG0515	serine threonine protein kinase
MTP03_RS17835	COG0702	epimerase
MTP03_RS17840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MTP03_RS17840	COG0519	Catalyzes the synthesis of GMP from XMP
MTP03_RS17860	COG0516	GMP reductase activity
MTP03_RS17895	COG0459	protein refolding
MTP03_RS17900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MTP03_RS17935	COG0456	acetyltransferase
MTP03_RS17960	COG2154	pterin-4-alpha-carbinolamine dehydratase
MTP03_RS17975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MTP03_RS18010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MTP03_RS18020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MTP03_RS18050	COG1674	ftsk spoiiie
MTP03_RS18060	COG1404	Belongs to the peptidase S8 family
MTP03_RS18140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP03_RS18155	COG0203	ribosomal protein L17
MTP03_RS18160	COG0202	RNA polymerase activity
MTP03_RS18165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MTP03_RS18170	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MTP03_RS18175	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MTP03_RS18180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MTP03_RS18190	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MTP03_RS18195	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MTP03_RS18210	COG0789	Transcriptional regulator
MTP03_RS18220	COG0563	adenylate kinase activity
MTP03_RS18245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MTP03_RS18250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MTP03_RS18255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MTP03_RS18295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MTP03_RS18300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MTP03_RS18305	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MTP03_RS18360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MTP03_RS18365	COG0255	Belongs to the universal ribosomal protein uL29 family
MTP03_RS18370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MTP03_RS18375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MTP03_RS18385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MTP03_RS18390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MTP03_RS18395	COG0089	rRNA binding
MTP03_RS18400	COG0088	Forms part of the polypeptide exit tunnel
MTP03_RS18405	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MTP03_RS18410	COG0051	transcription antitermination factor activity, RNA binding
MTP03_RS18440	COG2072	flavoprotein involved in K transport
MTP03_RS18445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MTP03_RS18475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MTP03_RS18480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MTP03_RS18485	COG0049	tRNA binding
MTP03_RS18490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MTP03_RS18510	COG1131	(ABC) transporter
MTP03_RS18535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MTP03_RS18560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MTP03_RS18580	COG1595	DNA-templated transcription, initiation
MTP03_RS18590	COG0640	Transcriptional regulator
MTP03_RS18625	COG3842	ATPase activity
MTP03_RS18630	COG1653	transport
MTP03_RS18690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MTP03_RS18715	COG0745	RESPONSE REGULATOR receiver
MTP03_RS18725	COG2897	thiosulfate sulfurtransferase activity
MTP03_RS18735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MTP03_RS18745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MTP03_RS18755	COG4044	May play a role in the intracellular transport of hydrophobic ligands
MTP03_RS18765	COG1309	transcriptional regulator
MTP03_RS18820	COG1294	oxidase, subunit
MTP03_RS18830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MTP03_RS18850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MTP03_RS18890	COG1113	amino acid transport
MTP03_RS18895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MTP03_RS18920	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS18930	COG1301	dicarboxylic acid transport
MTP03_RS18940	COG4565	transcriptional regulatory protein
MTP03_RS18950	COG3938	Belongs to the proline racemase family
MTP03_RS18955	COG0604	alcohol dehydrogenase
MTP03_RS18975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MTP03_RS18980	COG1113	amino acid transport
MTP03_RS18985	COG2084	Dehydrogenase
MTP03_RS18995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MTP03_RS19005	COG0477	Major facilitator Superfamily
MTP03_RS19010	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS19015	COG1063	alcohol dehydrogenase
MTP03_RS19020	COG1362	aminopeptidase activity
MTP03_RS19025	COG0047	phosphoribosylformylglycinamidine synthase activity
MTP03_RS19030	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MTP03_RS19050	COG0386	Belongs to the glutathione peroxidase family
MTP03_RS19060	COG0477	Major facilitator Superfamily
MTP03_RS19070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MTP03_RS19080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MTP03_RS19100	COG2205	protein histidine kinase activity
MTP03_RS19105	COG0745	RESPONSE REGULATOR receiver
MTP03_RS19120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MTP03_RS19135	COG1024	Enoyl-CoA hydratase
MTP03_RS19180	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MTP03_RS19190	COG1305	Transglutaminase-like
MTP03_RS19200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MTP03_RS19235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MTP03_RS19240	COG0788	formyltetrahydrofolate deformylase activity
MTP03_RS19265	COG2733	membrane
MTP03_RS19270	COG2326	polyphosphate kinase activity
MTP03_RS19280	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS19285	COG0583	DNA-binding transcription factor activity
MTP03_RS19300	COG2224	Isocitrate lyase
MTP03_RS19315	COG5285	phytanoyl-CoA dioxygenase
MTP03_RS19375	COG1132	(ABC) transporter
MTP03_RS19445	COG1535	isochorismatase
MTP03_RS19445	COG3433	isochorismatase activity
MTP03_RS19470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTP03_RS19480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP03_RS19515	COG0326	Molecular chaperone. Has ATPase activity
MTP03_RS19590	COG1006	Multisubunit Na H antiporter MnhC subunit
MTP03_RS19610	COG1320	monovalent cation:proton antiporter activity
MTP03_RS19615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MTP03_RS19640	COG1120	ATPase activity
MTP03_RS19645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP03_RS19650	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MTP03_RS19690	COG4555	ABC transporter
MTP03_RS19715	COG0351	phosphomethylpyrimidine kinase
MTP03_RS19740	COG2197	response regulator
MTP03_RS19745	COG0477	Major facilitator Superfamily
MTP03_RS19750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MTP03_RS19760	COG2022	thiamine diphosphate biosynthetic process
MTP03_RS19775	COG0352	thiamine-phosphate diphosphorylase activity
MTP03_RS19790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MTP03_RS19805	COG1120	ATPase activity
MTP03_RS19810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP03_RS19815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP03_RS19830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MTP03_RS19840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP03_RS19855	COG1132	(ABC) transporter
MTP03_RS19865	COG1132	(ABC) transporter
MTP03_RS19895	COG0657	acetylesterase activity
MTP03_RS19930	COG4941	Belongs to the sigma-70 factor family
MTP03_RS19945	COG1088	dTDP-glucose 4,6-dehydratase activity
MTP03_RS19950	COG1309	transcriptional regulator
MTP03_RS19955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MTP03_RS19960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MTP03_RS19995	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS20030	COG1414	Transcriptional regulator
MTP03_RS20050	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS20055	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS20060	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MTP03_RS20075	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS20080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MTP03_RS20125	COG2124	cytochrome p450
MTP03_RS20130	COG0183	Belongs to the thiolase family
MTP03_RS20135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MTP03_RS20140	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS20150	COG1024	Enoyl-CoA hydratase
MTP03_RS20175	COG1309	transcriptional regulator
MTP03_RS20180	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS20185	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS20190	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS20205	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS20225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MTP03_RS20240	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS20245	COG1053	succinate dehydrogenase
MTP03_RS20275	COG2030	dehydratase
MTP03_RS20295	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS20300	COG2030	dehydratase
MTP03_RS20395	COG2801	Transposase and inactivated derivatives
MTP03_RS20405	COG0243	molybdopterin cofactor binding
MTP03_RS20415	COG2508	Transcriptional regulator
MTP03_RS20420	COG2072	flavoprotein involved in K transport
MTP03_RS20450	COG1278	Cold shock
MTP03_RS20520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MTP03_RS20525	COG0601	transmembrane transport
MTP03_RS20535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MTP03_RS20550	COG1131	(ABC) transporter
MTP03_RS20570	COG0477	Major facilitator Superfamily
MTP03_RS20595	COG0494	nUDIX hydrolase
MTP03_RS20600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MTP03_RS20620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MTP03_RS20670	COG1024	Enoyl-CoA hydratase
MTP03_RS20690	COG2814	Major facilitator Superfamily
MTP03_RS20705	COG0477	Major facilitator Superfamily
MTP03_RS20725	COG2124	cytochrome p450
MTP03_RS20755	COG1021	2,3-dihydroxybenzoate-AMP ligase
MTP03_RS20765	COG3473	Maleate cis-trans isomerase
MTP03_RS20790	COG1408	metallophosphoesterase
MTP03_RS20805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MTP03_RS20810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MTP03_RS20815	COG1764	response to oxidative stress
MTP03_RS20850	COG0583	DNA-binding transcription factor activity
MTP03_RS20885	COG1309	transcriptional regulator
MTP03_RS20910	COG3473	Maleate cis-trans isomerase
MTP03_RS20915	COG1309	transcriptional regulator
MTP03_RS20920	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS20925	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS20940	COG1021	2,3-dihydroxybenzoate-AMP ligase
MTP03_RS20945	COG2814	Major facilitator Superfamily
MTP03_RS20950	COG2814	Major facilitator Superfamily
MTP03_RS20995	COG1959	2 iron, 2 sulfur cluster binding
MTP03_RS21000	COG0300	oxidoreductase activity
MTP03_RS21025	COG2807	transmembrane transport
MTP03_RS21030	COG1802	Transcriptional regulator
MTP03_RS21035	COG0179	Fumarylacetoacetate (FAA) hydrolase
MTP03_RS21055	COG0697	spore germination
MTP03_RS21100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MTP03_RS21135	COG0564	pseudouridine synthase activity
MTP03_RS21155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MTP03_RS21180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MTP03_RS21210	COG0640	Transcriptional regulator
MTP03_RS21225	COG1793	dna ligase
MTP03_RS21230	COG2318	DinB family
MTP03_RS21240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MTP03_RS21245	COG4977	sequence-specific DNA binding
MTP03_RS21250	COG0343	queuine tRNA-ribosyltransferase activity
MTP03_RS21285	COG0287	Prephenate dehydrogenase
MTP03_RS21340	COG0739	heme binding
MTP03_RS21400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MTP03_RS21440	COG2030	dehydratase
MTP03_RS21465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MTP03_RS21470	COG1024	Enoyl-CoA hydratase
MTP03_RS21495	COG1960	acyl-CoA dehydrogenase activity
MTP03_RS21505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MTP03_RS21560	COG3321	synthase
MTP03_RS21560	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS21560	COG0604	alcohol dehydrogenase
MTP03_RS21600	COG1216	Glycosyl transferase, family 2
MTP03_RS21605	COG0318	PFAM AMP-dependent synthetase and ligase
MTP03_RS21610	COG2814	Major facilitator Superfamily
MTP03_RS21640	COG1476	TRANSCRIPTIONal
MTP03_RS21650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MTP03_RS21660	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS21665	COG0006	proline dipeptidase activity
MTP03_RS21670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MTP03_RS21675	COG1473	amidohydrolase
MTP03_RS21690	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS21700	COG4221	oxidoreductase activity
MTP03_RS21705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MTP03_RS21720	COG1122	ATPase activity
MTP03_RS21725	COG1268	BioY protein
MTP03_RS21735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MTP03_RS21765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MTP03_RS21780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MTP03_RS21805	COG1174	glycine betaine transport
MTP03_RS21845	COG1376	ErfK ybiS ycfS ynhG family protein
MTP03_RS21850	COG0659	secondary active sulfate transmembrane transporter activity
MTP03_RS21855	COG2205	protein histidine kinase activity
MTP03_RS21860	COG0745	RESPONSE REGULATOR receiver
MTP03_RS21895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MTP03_RS21900	COG0785	Cytochrome C biogenesis protein
MTP03_RS21930	COG0758	DNA mediated transformation
MTP03_RS21965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MTP03_RS21975	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MTP03_RS22035	COG0359	binds to the 23S rRNA
MTP03_RS22050	COG0360	Binds together with S18 to 16S ribosomal RNA
MTP03_RS22130	COG0183	Belongs to the thiolase family
MTP03_RS22145	COG1024	Enoyl-CoA hydratase
MTP03_RS22180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MTP03_RS22195	COG1260	myo-inositol-1-phosphate synthase
MTP03_RS22260	COG1358	cellular component organization or biogenesis
MTP03_RS22275	COG1297	OPT oligopeptide transporter protein
MTP03_RS22295	COG2814	Major facilitator Superfamily
MTP03_RS22305	COG4122	O-methyltransferase activity
MTP03_RS22400	COG0519	Catalyzes the synthesis of GMP from XMP
MTP03_RS22405	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS22435	COG3409	Peptidoglycan-binding domain 1 protein
MTP03_RS22435	COG0860	N-Acetylmuramoyl-L-alanine amidase
MTP03_RS22465	COG0706	membrane insertase activity
MTP03_RS22475	COG0594	ribonuclease P activity
MTP03_RS22555	COG2814	Major facilitator Superfamily
MTP03_RS22560	COG2814	Major facilitator Superfamily
MTP03_RS22615	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MTP03_RS22650	COG2124	cytochrome p450
MTP03_RS22680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MTP03_RS22690	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS22725	COG2409	Drug exporters of the RND superfamily
MTP03_RS22770	COG0531	amino acid
MTP03_RS22780	COG1984	allophanate hydrolase subunit 2
MTP03_RS22785	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MTP03_RS22810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MTP03_RS22810	COG2124	cytochrome p450
MTP03_RS22905	COG4988	ABC transporter
MTP03_RS22940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MTP03_RS22945	COG1012	belongs to the aldehyde dehydrogenase family
MTP03_RS22965	COG0135	phosphoribosylanthranilate isomerase activity
MTP03_RS22975	COG0860	N-Acetylmuramoyl-L-alanine amidase
MTP03_RS22980	COG0860	N-Acetylmuramoyl-L-alanine amidase
MTP03_RS22995	COG1028	Short-chain dehydrogenase reductase Sdr
MTP03_RS23035	COG1012	belongs to the aldehyde dehydrogenase family