locus-tag	class	description
CIG75_RS00010	COG4467	Involved in initiation control of chromosome replication
CIG75_RS00015	COG1774	PSP1 C-terminal conserved region
CIG75_RS00020	COG0470	DNA polymerase III
CIG75_RS00025	COG1728	Protein conserved in bacteria
CIG75_RS00030	COG3870	Protein conserved in bacteria
CIG75_RS00035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIG75_RS00040	COG1982	Orn Lys Arg decarboxylase major
CIG75_RS00065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CIG75_RS00070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CIG75_RS00075	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CIG75_RS00080	COG3852	Histidine kinase
CIG75_RS00095	COG0590	tRNA wobble adenosine to inosine editing
CIG75_RS00120	COG1428	Deoxynucleoside kinase
CIG75_RS00125	COG1428	Deoxynucleoside kinase
CIG75_RS00135	COG3387	PFAM Glycoside hydrolase 15-related
CIG75_RS00140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CIG75_RS00150	COG1686	Belongs to the peptidase S11 family
CIG75_RS00155	COG0516	GMP reductase activity
CIG75_RS00155	COG0517	IMP dehydrogenase activity
CIG75_RS00190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CIG75_RS00195	COG0187	DNA topoisomerase II activity
CIG75_RS00205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIG75_RS00210	COG2501	S4 domain
CIG75_RS00215	COG0592	DNA-directed DNA polymerase activity
CIG75_RS00225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CIG75_RS00230	COG0594	ribonuclease P activity
CIG75_RS00235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CIG75_RS00245	COG1847	R3H domain protein
CIG75_RS00250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CIG75_RS00255	COG0445	tRNA wobble uridine modification
CIG75_RS00260	COG0357	Ribosomal RNA small subunit methyltransferase G
CIG75_RS00265	COG1475	DNA binding
CIG75_RS00270	COG1192	Involved in chromosome partitioning
CIG75_RS00275	COG1475	DNA binding
CIG75_RS00285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CIG75_RS00330	COG0668	transmembrane transport
CIG75_RS00335	COG4481	Protein conserved in bacteria
CIG75_RS00340	COG0243	molybdopterin cofactor binding
CIG75_RS00360	COG0012	GTP binding
CIG75_RS00370	COG0629	single-stranded DNA binding
CIG75_RS00400	COG4941	Belongs to the sigma-70 factor family
CIG75_RS00410	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CIG75_RS00425	COG5002	protein histidine kinase activity
CIG75_RS00430	COG0745	RESPONSE REGULATOR receiver
CIG75_RS00450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIG75_RS00455	COG0488	(ABC) transporter
CIG75_RS00465	COG0626	cystathionine gamma-synthase activity
CIG75_RS00470	COG0484	heat shock protein binding
CIG75_RS00505	COG0470	DNA polymerase III
CIG75_RS00505	COG1067	ATP-dependent peptidase activity
CIG75_RS00510	COG0305	Participates in initiation and elongation during chromosome replication
CIG75_RS00520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CIG75_RS00535	COG0745	RESPONSE REGULATOR receiver
CIG75_RS00540	COG5002	protein histidine kinase activity
CIG75_RS00545	COG4863	YycH protein
CIG75_RS00555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CIG75_RS00565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIG75_RS00645	COG3655	Transcriptional regulator
CIG75_RS00655	COG1959	2 iron, 2 sulfur cluster binding
CIG75_RS00665	COG1132	(ABC) transporter
CIG75_RS00670	COG1132	(ABC) transporter
CIG75_RS00690	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIG75_RS00695	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CIG75_RS00715	COG1309	transcriptional regulator
CIG75_RS00720	COG2076	Multidrug Resistance protein
CIG75_RS00725	COG2076	Multidrug Resistance protein
CIG75_RS00735	COG0028	Belongs to the TPP enzyme family
CIG75_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS00760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIG75_RS00790	COG0656	L-ascorbic acid biosynthetic process
CIG75_RS00795	COG2814	Major facilitator Superfamily
CIG75_RS00810	COG3655	Transcriptional regulator
CIG75_RS00830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CIG75_RS00845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CIG75_RS00850	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CIG75_RS00865	COG0126	phosphoglycerate kinase activity
CIG75_RS00870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CIG75_RS00875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CIG75_RS00920	COG2824	Alkylphosphonate utilization operon protein PhnA
CIG75_RS00930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIG75_RS00930	COG2207	Transcriptional regulator
CIG75_RS00935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIG75_RS00940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_RS00945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_RS00950	COG2819	hydrolase of the alpha beta superfamily
CIG75_RS00990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CIG75_RS01000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CIG75_RS01005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CIG75_RS01010	COG3832	glyoxalase III activity
CIG75_RS01020	COG0778	Nitroreductase
CIG75_RS01025	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_RS01030	COG4605	iron ion homeostasis
CIG75_RS01035	COG4604	ABC transporter, ATP-binding protein
CIG75_RS01040	COG4607	ABC-type enterochelin transport system periplasmic component
CIG75_RS01045	COG1122	ATPase activity
CIG75_RS01050	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CIG75_RS01060	COG0310	cobalt ion transport
CIG75_RS01065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIG75_RS01095	COG1361	Conserved repeat domain
CIG75_RS01100	COG0789	Transcriptional regulator
CIG75_RS01115	COG1187	pseudouridine synthase activity
CIG75_RS01120	COG2814	Major facilitator Superfamily
CIG75_RS01130	COG4895	conserved protein (DUF2196)
CIG75_RS01135	COG0488	(ABC) transporter
CIG75_RS01140	COG1214	PFAM Peptidase M22, glycoprotease
CIG75_RS01140	COG0456	acetyltransferase
CIG75_RS01155	COG1643	Atp-dependent helicase
CIG75_RS01190	COG0656	L-ascorbic acid biosynthetic process
CIG75_RS01215	COG0457	Tetratricopeptide repeat
CIG75_RS01215	COG0463	Glycosyl transferase, family 2
CIG75_RS01225	COG0463	Glycosyl transferase, family 2
CIG75_RS01250	COG0813	purine-nucleoside phosphorylase activity
CIG75_RS01265	COG0861	Integral membrane protein TerC family
CIG75_RS01270	COG5002	protein histidine kinase activity
CIG75_RS01275	COG1054	Belongs to the UPF0176 family
CIG75_RS01280	COG2814	Major facilitator Superfamily
CIG75_RS01290	COG1253	flavin adenine dinucleotide binding
CIG75_RS01295	COG0515	serine threonine protein kinase
CIG75_RS01305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIG75_RS01330	COG1970	mechanosensitive ion channel activity
CIG75_RS01335	COG2814	Major facilitator Superfamily
CIG75_RS01340	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CIG75_RS01345	COG3153	acetyltransferase
CIG75_RS01345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIG75_RS01355	COG1132	(ABC) transporter
CIG75_RS01360	COG1132	(ABC) transporter
CIG75_RS01375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CIG75_RS01380	COG2363	Small membrane protein
CIG75_RS01385	COG0697	spore germination
CIG75_RS01400	COG0814	amino acid
CIG75_RS01425	COG0436	Aminotransferase
CIG75_RS01430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIG75_RS01435	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CIG75_RS01440	COG0010	Belongs to the arginase family
CIG75_RS01475	COG0730	response to heat
CIG75_RS01480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIG75_RS01480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIG75_RS01485	COG0425	Belongs to the sulfur carrier protein TusA family
CIG75_RS01490	COG2210	Belongs to the sulfur carrier protein TusA family
CIG75_RS01495	COG1937	Protein conserved in bacteria
CIG75_RS01530	COG3829	transcription factor binding
CIG75_RS01535	COG0604	alcohol dehydrogenase
CIG75_RS01540	COG1509	lysine 2,3-aminomutase activity
CIG75_RS01550	COG1193	negative regulation of DNA recombination
CIG75_RS01555	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CIG75_RS01560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_RS01580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CIG75_RS01600	COG0247	lactate metabolic process
CIG75_RS01600	COG2181	nitrate reductase activity
CIG75_RS01610	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_RS01615	COG1024	Enoyl-CoA hydratase
CIG75_RS01620	COG1960	acyl-CoA dehydrogenase activity
CIG75_RS01625	COG1960	acyl-CoA dehydrogenase activity
CIG75_RS01640	COG2131	deaminase
CIG75_RS01645	COG2208	phosphoserine phosphatase activity
CIG75_RS01650	COG2304	oxidoreductase activity
CIG75_RS01655	COG0515	serine threonine protein kinase
CIG75_RS01660	COG2966	Psort location CytoplasmicMembrane, score
CIG75_RS01670	COG0037	tRNA processing
CIG75_RS01680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CIG75_RS01690	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CIG75_RS01695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CIG75_RS01700	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CIG75_RS01710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CIG75_RS01715	COG0242	peptide deformylase activity
CIG75_RS01720	COG2204	response regulator
CIG75_RS01725	COG1607	acyl-coa hydrolase
CIG75_RS01730	COG3246	L-lysine catabolic process to acetate
CIG75_RS01745	COG2171	N-acyltransferase activity
CIG75_RS01750	COG1473	amidohydrolase
CIG75_RS01765	COG1494	fructose-1,6-bisphosphatase
CIG75_RS01770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CIG75_RS01790	COG0254	rRNA binding
CIG75_RS01810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CIG75_RS01830	COG0009	L-threonylcarbamoyladenylate synthase
CIG75_RS01845	COG1971	Probably functions as a manganese efflux pump
CIG75_RS01860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CIG75_RS01870	COG1132	(ABC) transporter
CIG75_RS01875	COG0698	ribose 5-phosphate isomerase
CIG75_RS01880	COG4475	Protein of unknown function (DUF436)
CIG75_RS01885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CIG75_RS01890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CIG75_RS01895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CIG75_RS01920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CIG75_RS01925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CIG75_RS01930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CIG75_RS01935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CIG75_RS01940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CIG75_RS01945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CIG75_RS01950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CIG75_RS01955	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIG75_RS01960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIG75_RS01965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIG75_RS01975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CIG75_RS01980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CIG75_RS01985	COG0839	Belongs to the complex I subunit 6 family
CIG75_RS01990	COG0713	ATP synthesis coupled electron transport
CIG75_RS01995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CIG75_RS02005	COG1007	ATP synthesis coupled electron transport
CIG75_RS02020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CIG75_RS02030	COG2385	sporulation resulting in formation of a cellular spore
CIG75_RS02035	COG0739	heme binding
CIG75_RS02040	COG1609	Transcriptional regulator
CIG75_RS02045	COG1077	Cell shape determining protein MreB Mrl
CIG75_RS02050	COG4786	Flagellar basal body rod
CIG75_RS02065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CIG75_RS02080	COG1739	Uncharacterized protein family UPF0029
CIG75_RS02100	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_RS02120	COG3693	PFAM glycoside hydrolase, family 10
CIG75_RS02125	COG0793	Belongs to the peptidase S41A family
CIG75_RS02150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CIG75_RS02180	COG1316	TRANSCRIPTIONal
CIG75_RS02195	COG1316	TRANSCRIPTIONal
CIG75_RS02205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CIG75_RS02210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIG75_RS02235	COG0840	transmembrane signaling receptor activity
CIG75_RS02245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CIG75_RS02250	COG0573	inorganic phosphate transmembrane transporter activity
CIG75_RS02255	COG0581	inorganic phosphate transmembrane transporter activity
CIG75_RS02260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CIG75_RS02265	COG0704	Plays a role in the regulation of phosphate uptake
CIG75_RS02270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CIG75_RS02275	COG0745	RESPONSE REGULATOR receiver
CIG75_RS02280	COG5002	protein histidine kinase activity
CIG75_RS02300	COG1396	sequence-specific DNA binding
CIG75_RS02325	COG1307	EDD domain protein, DegV family
CIG75_RS02330	COG1040	competence protein
CIG75_RS02350	COG4786	Flagellar basal body rod
CIG75_RS02350	COG1256	bacterial-type flagellum assembly
CIG75_RS02355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIG75_RS02365	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CIG75_RS02370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CIG75_RS02375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIG75_RS02380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CIG75_RS02390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CIG75_RS02415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIG75_RS02420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CIG75_RS02425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CIG75_RS02430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIG75_RS02430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CIG75_RS02435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CIG75_RS02440	COG2089	acid synthase
CIG75_RS02445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CIG75_RS02450	COG1083	cytidylyl-transferase
CIG75_RS02470	COG4717	serine-type aminopeptidase activity
CIG75_RS02475	COG0010	Belongs to the arginase family
CIG75_RS02485	COG0730	response to heat
CIG75_RS02490	COG2046	Belongs to the sulfate adenylyltransferase family
CIG75_RS02495	COG1595	DNA-templated transcription, initiation
CIG75_RS02500	COG5662	AntiSigma factor
CIG75_RS02510	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CIG75_RS02520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIG75_RS02525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CIG75_RS02540	COG3708	Transcriptional regulator
CIG75_RS02540	COG2207	Transcriptional regulator
CIG75_RS02545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_RS02550	COG1120	ATPase activity
CIG75_RS02560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIG75_RS02580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CIG75_RS02585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CIG75_RS02610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CIG75_RS02615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CIG75_RS02620	COG0166	Belongs to the GPI family
CIG75_RS02625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIG75_RS02635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CIG75_RS02640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CIG75_RS02680	COG2814	Major facilitator Superfamily
CIG75_RS02720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIG75_RS02725	COG1695	Transcriptional regulator
CIG75_RS02740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIG75_RS02770	COG1011	Hydrolase
CIG75_RS02790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CIG75_RS02795	COG3321	synthase
CIG75_RS02795	COG0300	oxidoreductase activity
CIG75_RS02795	COG4221	oxidoreductase activity
CIG75_RS02795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIG75_RS02800	COG3321	synthase
CIG75_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS02800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIG75_RS02800	COG0318	PFAM AMP-dependent synthetase and ligase
CIG75_RS02800	COG0300	oxidoreductase activity
CIG75_RS02805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIG75_RS02810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIG75_RS02820	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CIG75_RS02830	COG1280	lysine exporter protein (LysE YggA)
CIG75_RS02845	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CIG75_RS02850	COG2814	Major facilitator Superfamily
CIG75_RS02855	COG4264	IucA IucC family
CIG75_RS02860	COG2814	Major facilitator Superfamily
CIG75_RS02875	COG1475	DNA binding
CIG75_RS02885	COG2911	Protein conserved in bacteria
CIG75_RS02885	COG1361	Conserved repeat domain
CIG75_RS02885	COG3266	domain, Protein
CIG75_RS02910	COG2310	stress, protein
CIG75_RS02915	COG2310	stress, protein
CIG75_RS02920	COG2310	stress, protein
CIG75_RS02925	COG2310	stress, protein
CIG75_RS02930	COG0861	Integral membrane protein TerC family
CIG75_RS02945	COG1358	cellular component organization or biogenesis
CIG75_RS02975	COG5002	protein histidine kinase activity
CIG75_RS02975	COG3850	Histidine kinase
CIG75_RS02990	COG1840	ABC-type Fe3 transport system, periplasmic component
CIG75_RS02995	COG0395	ABC-type sugar transport system, permease component
CIG75_RS03000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CIG75_RS03010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIG75_RS03015	COG5609	conserved protein (DUF2294)
CIG75_RS03020	COG0531	amino acid
CIG75_RS03035	COG0477	Major facilitator Superfamily
CIG75_RS03040	COG3384	dioxygenase
CIG75_RS03045	COG2076	Multidrug Resistance protein
CIG75_RS03050	COG2076	Multidrug Resistance protein
CIG75_RS03060	COG2814	Major facilitator Superfamily
CIG75_RS03065	COG3973	AAA domain
CIG75_RS03070	COG2814	Major facilitator Superfamily
CIG75_RS03075	COG1876	peptidase activity
CIG75_RS03080	COG3973	AAA domain
CIG75_RS03085	COG2801	Transposase and inactivated derivatives
CIG75_RS03140	COG4193	domain, Protein
CIG75_RS03155	COG3299	homolog of phage Mu protein gp47
CIG75_RS03195	COG5632	N-Acetylmuramoyl-L-alanine amidase
CIG75_RS03245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CIG75_RS03250	COG1999	signal sequence binding
CIG75_RS03265	COG1842	Phage shock protein A
CIG75_RS03270	COG4758	membrane
CIG75_RS03275	COG4585	Histidine kinase
CIG75_RS03280	COG2197	response regulator
CIG75_RS03290	COG4991	sh3 domain protein
CIG75_RS03305	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIG75_RS03310	COG1309	transcriptional regulator
CIG75_RS03315	COG0640	Transcriptional regulator
CIG75_RS03360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIG75_RS03365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CIG75_RS03370	COG0277	FAD linked oxidase domain protein
CIG75_RS03375	COG4533	DNA binding
CIG75_RS03380	COG4533	DNA binding
CIG75_RS03385	COG1132	(ABC) transporter
CIG75_RS03390	COG1132	(ABC) transporter
CIG75_RS03395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CIG75_RS03400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CIG75_RS03405	COG2197	response regulator
CIG75_RS03410	COG4585	Histidine kinase
CIG75_RS03420	COG0398	Pfam SNARE associated Golgi protein
CIG75_RS03425	COG0464	growth
CIG75_RS03430	COG0165	Argininosuccinate lyase
CIG75_RS03435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIG75_RS03455	COG4473	ABC transporter
CIG75_RS03460	COG1131	(ABC) transporter
CIG75_RS03465	COG0405	Gamma-glutamyltransferase
CIG75_RS03470	COG4608	Belongs to the ABC transporter superfamily
CIG75_RS03475	COG0444	Belongs to the ABC transporter superfamily
CIG75_RS03485	COG0601	transmembrane transport
CIG75_RS03490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CIG75_RS03495	COG1522	sequence-specific DNA binding
CIG75_RS03500	COG2059	Chromate
CIG75_RS03505	COG0778	Nitroreductase
CIG75_RS03525	COG4585	Histidine kinase
CIG75_RS03530	COG2197	response regulator
CIG75_RS03535	COG1131	(ABC) transporter
CIG75_RS03540	COG0842	Transport permease protein
CIG75_RS03540	COG1511	domain protein
CIG75_RS03545	COG1511	domain protein
CIG75_RS03545	COG0842	Transport permease protein
CIG75_RS03550	COG0842	Transport permease protein
CIG75_RS03560	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS03570	COG1929	Belongs to the glycerate kinase type-1 family
CIG75_RS03575	COG2814	Major facilitator Superfamily
CIG75_RS03585	COG2258	MOSC domain
CIG75_RS03605	COG3973	AAA domain
CIG75_RS03625	COG0528	UMP kinase activity
CIG75_RS03630	COG2226	methyltransferase
CIG75_RS03635	COG0402	S-adenosylhomocysteine deaminase activity
CIG75_RS03640	COG1201	RNA secondary structure unwinding
CIG75_RS03645	COG4496	protein, YerC YecD
CIG75_RS03650	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CIG75_RS03670	COG0750	zinc metalloprotease
CIG75_RS03680	COG0210	DNA helicase
CIG75_RS03685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_RS03685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_RS03690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CIG75_RS03695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIG75_RS03710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIG75_RS03725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CIG75_RS03730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CIG75_RS03735	COG0840	transmembrane signaling receptor activity
CIG75_RS03745	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CIG75_RS03765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIG75_RS03765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CIG75_RS03810	COG0778	Nitroreductase
CIG75_RS03825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CIG75_RS03830	COG0154	amidase activity
CIG75_RS03835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CIG75_RS03840	COG1597	lipid kinase activity
CIG75_RS03850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CIG75_RS03910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CIG75_RS03915	COG0488	(ABC) transporter
CIG75_RS03920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CIG75_RS03925	COG0596	Alpha beta hydrolase
CIG75_RS03930	COG0596	Alpha beta hydrolase
CIG75_RS03960	COG2169	Transcriptional regulator
CIG75_RS03965	COG2140	Oxalate decarboxylase
CIG75_RS03985	COG2801	Transposase and inactivated derivatives
CIG75_RS04005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CIG75_RS04010	COG2169	Transcriptional regulator
CIG75_RS04015	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CIG75_RS04025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_RS04030	COG1801	Protein of unknown function DUF72
CIG75_RS04045	COG1051	belongs to the nudix hydrolase family
CIG75_RS04050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_RS04065	COG2197	response regulator
CIG75_RS04070	COG4585	Histidine kinase
CIG75_RS04075	COG0778	Nitroreductase
CIG75_RS04085	COG1012	belongs to the aldehyde dehydrogenase family
CIG75_RS04095	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CIG75_RS04095	COG0646	methionine synthase
CIG75_RS04150	COG1388	LysM domain
CIG75_RS04150	COG3858	chitin binding
CIG75_RS04170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CIG75_RS04175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CIG75_RS04180	COG0640	Transcriptional regulator
CIG75_RS04185	COG0346	lactoylglutathione lyase activity
CIG75_RS04240	COG3214	Protein conserved in bacteria
CIG75_RS04255	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CIG75_RS04260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CIG75_RS04280	COG2346	COG2346, Truncated hemoglobins
CIG75_RS04285	COG1846	Transcriptional regulator
CIG75_RS04290	COG0477	Major facilitator Superfamily
CIG75_RS04295	COG0640	Transcriptional regulator
CIG75_RS04300	COG0667	Aldo Keto reductase
CIG75_RS04320	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CIG75_RS04355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CIG75_RS04360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CIG75_RS04380	COG3339	Conserved Protein
CIG75_RS04385	COG0018	arginyl-trna synthetase
CIG75_RS04390	COG3852	Histidine kinase
CIG75_RS04425	COG2205	protein histidine kinase activity
CIG75_RS04430	COG1136	(ABC) transporter
CIG75_RS04445	COG1024	Enoyl-CoA hydratase
CIG75_RS04475	COG0514	ATP-dependent DNA helicase (RecQ)
CIG75_RS04485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CIG75_RS04500	COG2801	Transposase and inactivated derivatives
CIG75_RS04520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_RS04535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_RS04555	COG5522	Integral membrane protein (intg_mem_TP0381)
CIG75_RS04560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CIG75_RS04570	COG5298	Protein conserved in bacteria
CIG75_RS04575	COG0488	(ABC) transporter
CIG75_RS04580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CIG75_RS04595	COG0658	competence protein
CIG75_RS04595	COG2333	competence protein COMEC
CIG75_RS04600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIG75_RS04615	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CIG75_RS04620	COG1278	Cold shock
CIG75_RS04625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIG75_RS04630	COG0861	Integral membrane protein TerC family
CIG75_RS04645	COG1755	Isoprenylcysteine carboxyl methyltransferase
CIG75_RS04650	COG3424	synthase
CIG75_RS04660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CIG75_RS04665	COG0360	Binds together with S18 to 16S ribosomal RNA
CIG75_RS04685	COG2508	Transcriptional regulator
CIG75_RS04690	COG3842	ATPase activity
CIG75_RS04695	COG1940	carbohydrate kinase activity
CIG75_RS04720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIG75_RS04745	COG0824	Thioesterase
CIG75_RS04750	COG0501	Belongs to the peptidase M48B family
CIG75_RS04775	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CIG75_RS04805	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CIG75_RS04825	COG2207	Transcriptional regulator
CIG75_RS04825	COG3708	Transcriptional regulator
CIG75_RS04875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_RS04890	COG0288	reversible hydration of carbon dioxide
CIG75_RS04900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CIG75_RS04910	COG1595	DNA-templated transcription, initiation
CIG75_RS04935	COG1846	Transcriptional regulator
CIG75_RS04945	COG2309	aminopeptidase activity
CIG75_RS04950	COG1194	a g-specific adenine glycosylase
CIG75_RS04975	COG0670	Belongs to the BI1 family
CIG75_RS04985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CIG75_RS04995	COG2186	Transcriptional regulator
CIG75_RS05000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIG75_RS05015	COG3944	biosynthesis protein
CIG75_RS05020	COG0438	transferase activity, transferring glycosyl groups
CIG75_RS05030	COG0745	RESPONSE REGULATOR receiver
CIG75_RS05035	COG5002	protein histidine kinase activity
CIG75_RS05035	COG3850	Histidine kinase
CIG75_RS05080	COG1012	belongs to the aldehyde dehydrogenase family
CIG75_RS05085	COG1408	metallophosphoesterase
CIG75_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS05150	COG1361	Conserved repeat domain
CIG75_RS05160	COG0561	phosphatase activity
CIG75_RS05185	COG3209	COG3209 Rhs family protein
CIG75_RS05200	COG1285	pathogenesis
CIG75_RS05235	COG4493	Belongs to the UPF0637 family
CIG75_RS05255	COG0737	Belongs to the 5'-nucleotidase family
CIG75_RS05260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CIG75_RS05280	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_RS05285	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_RS05300	COG0436	Aminotransferase
CIG75_RS05310	COG1309	transcriptional regulator
CIG75_RS05315	COG0328	RNA-DNA hybrid ribonuclease activity
CIG75_RS05325	COG1683	Conserved Protein
CIG75_RS05335	COG0473	3-isopropylmalate dehydrogenase activity
CIG75_RS05340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CIG75_RS05345	COG1414	Transcriptional regulator
CIG75_RS05355	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CIG75_RS05355	COG2199	diguanylate cyclase activity
CIG75_RS05360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CIG75_RS05375	COG1131	(ABC) transporter
CIG75_RS05380	COG1511	domain protein
CIG75_RS05385	COG1309	transcriptional regulator
CIG75_RS05390	COG2766	serine protein kinase
CIG75_RS05395	COG2718	Belongs to the UPF0229 family
CIG75_RS05400	COG2719	SpoVR family
CIG75_RS05430	COG1337	RAMP superfamily
CIG75_RS05475	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS05480	COG0189	ligase activity
CIG75_RS05485	COG4399	Belongs to the UPF0754 family
CIG75_RS05490	COG3679	Belongs to the UPF0342 family
CIG75_RS05495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CIG75_RS05510	COG4109	DRTGG domain
CIG75_RS05520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIG75_RS05520	COG3153	acetyltransferase
CIG75_RS05525	COG0587	DNA-directed DNA polymerase activity
CIG75_RS05530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CIG75_RS05535	COG0281	malic enzyme
CIG75_RS05545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CIG75_RS05550	COG0825	malonyl-CoA metabolic process
CIG75_RS05555	COG0205	6-phosphofructokinase activity
CIG75_RS05565	COG0824	Thioesterase
CIG75_RS05570	COG3030	protein affecting phage T7 exclusion by the F plasmid
CIG75_RS05580	COG0538	isocitrate dehydrogenase activity
CIG75_RS05585	COG0039	L-malate dehydrogenase activity
CIG75_RS05590	COG0601	transmembrane transport
CIG75_RS05595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CIG75_RS05600	COG0444	Belongs to the ABC transporter superfamily
CIG75_RS05605	COG4608	Belongs to the ABC transporter superfamily
CIG75_RS05610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIG75_RS05610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CIG75_RS05615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CIG75_RS05620	COG1971	Probably functions as a manganese efflux pump
CIG75_RS05625	COG0237	dephospho-CoA kinase activity
CIG75_RS05650	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CIG75_RS05660	COG0372	Belongs to the citrate synthase family
CIG75_RS05690	COG0517	IMP dehydrogenase activity
CIG75_RS05695	COG0517	IMP dehydrogenase activity
CIG75_RS05710	COG1543	Belongs to the glycosyl hydrolase 57 family
CIG75_RS05720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CIG75_RS05740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CIG75_RS05750	COG0739	heme binding
CIG75_RS05760	COG0306	phosphate transporter
CIG75_RS05785	COG1979	alcohol dehydrogenase
CIG75_RS05790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CIG75_RS05795	COG0436	Aminotransferase
CIG75_RS05800	COG1024	Enoyl-CoA hydratase
CIG75_RS05815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_RS05845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CIG75_RS05950	COG0791	NLP P60 protein
CIG75_RS05955	COG1129	ABC transporter
CIG75_RS05970	COG0745	RESPONSE REGULATOR receiver
CIG75_RS05975	COG5002	protein histidine kinase activity
CIG75_RS05990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CIG75_RS05995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CIG75_RS06000	COG0569	domain protein
CIG75_RS06005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIG75_RS06015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CIG75_RS06020	COG0072	phenylalanine-tRNA ligase activity
CIG75_RS06020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIG75_RS06025	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CIG75_RS06040	COG1193	negative regulation of DNA recombination
CIG75_RS06045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIG75_RS06050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CIG75_RS06095	COG1606	tRNA processing
CIG75_RS06100	COG1691	(AIR) carboxylase
CIG75_RS06105	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CIG75_RS06225	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIG75_RS06255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CIG75_RS06265	COG1464	Belongs to the NlpA lipoprotein family
CIG75_RS06290	COG0477	Major facilitator Superfamily
CIG75_RS06290	COG2814	Major facilitator Superfamily
CIG75_RS06295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CIG75_RS06310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CIG75_RS06315	COG0632	four-way junction helicase activity
CIG75_RS06320	COG2255	four-way junction helicase activity
CIG75_RS06325	COG1191	sigma factor activity
CIG75_RS06330	COG5183	chlorophyll binding
CIG75_RS06330	COG2133	pyrroloquinoline quinone binding
CIG75_RS06340	COG2385	sporulation resulting in formation of a cellular spore
CIG75_RS06350	COG0343	queuine tRNA-ribosyltransferase activity
CIG75_RS06355	COG1862	Preprotein translocase
CIG75_RS06365	COG3706	GGDEF domain
CIG75_RS06370	COG2323	membrane
CIG75_RS06375	COG2244	polysaccharide biosynthetic process
CIG75_RS06390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIG75_RS06395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CIG75_RS06400	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CIG75_RS06400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CIG75_RS06405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIG75_RS06410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CIG75_RS06415	COG1490	D-aminoacyl-tRNA deacylase activity
CIG75_RS06440	COG2814	Major facilitator Superfamily
CIG75_RS06490	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CIG75_RS06495	COG2807	transmembrane transport
CIG75_RS06520	COG1794	racemase activity, acting on amino acids and derivatives
CIG75_RS06525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CIG75_RS06530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CIG75_RS06535	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS06575	COG1073	alpha beta
CIG75_RS06585	COG1164	Oligoendopeptidase f
CIG75_RS06595	COG2311	Membrane
CIG75_RS06740	COG2814	Major facilitator Superfamily
CIG75_RS06750	COG2217	Heavy metal translocating P-type atpase
CIG75_RS06755	COG0427	acetyl-CoA hydrolase
CIG75_RS06770	COG5002	protein histidine kinase activity
CIG75_RS06785	COG0646	methionine synthase
CIG75_RS06785	COG1410	methionine synthase
CIG75_RS06795	COG1418	mRNA catabolic process
CIG75_RS06800	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CIG75_RS06810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CIG75_RS06835	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CIG75_RS06840	COG4991	sh3 domain protein
CIG75_RS06840	COG3103	Sh3 type 3 domain protein
CIG75_RS06840	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_RS06845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIG75_RS06850	COG2244	polysaccharide biosynthetic process
CIG75_RS06860	COG0124	histidyl-tRNA synthetase
CIG75_RS06865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CIG75_RS06875	COG0024	Methionine aminopeptidase
CIG75_RS06895	COG2364	Membrane
CIG75_RS06900	COG1959	2 iron, 2 sulfur cluster binding
CIG75_RS06905	COG1104	cysteine desulfurase activity
CIG75_RS06930	COG0450	alkyl hydroperoxide reductase
CIG75_RS06935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIG75_RS06955	COG0628	permease
CIG75_RS06960	COG4472	Bacterial protein of unknown function (DUF965)
CIG75_RS06965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CIG75_RS06970	COG3906	Belongs to the UPF0473 family
CIG75_RS06980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CIG75_RS06985	COG4122	O-methyltransferase activity
CIG75_RS06990	COG0572	uridine kinase
CIG75_RS06995	COG0768	penicillin binding
CIG75_RS07020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CIG75_RS07030	COG0791	NLP P60 protein
CIG75_RS07030	COG1388	LysM domain
CIG75_RS07035	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CIG75_RS07040	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CIG75_RS07050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIG75_RS07055	COG1534	Rna-binding protein
CIG75_RS07065	COG1713	HD superfamily hydrolase involved in NAD metabolism
CIG75_RS07070	COG0799	negative regulation of ribosome biogenesis
CIG75_RS07075	COG2226	methyltransferase
CIG75_RS07080	COG3858	chitin binding
CIG75_RS07080	COG1388	LysM domain
CIG75_RS07085	COG0495	leucyl-tRNA aminoacylation
CIG75_RS07095	COG1181	Belongs to the D-alanine--D-alanine ligase family
CIG75_RS07105	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CIG75_RS07110	COG1596	polysaccharide export
CIG75_RS07110	COG1555	photosystem II stabilization
CIG75_RS07140	COG1595	DNA-templated transcription, initiation
CIG75_RS07155	COG1141	Ferredoxin
CIG75_RS07160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CIG75_RS07165	COG2084	Dehydrogenase
CIG75_RS07170	COG0714	Associated with various cellular activities
CIG75_RS07190	COG0183	Belongs to the thiolase family
CIG75_RS07220	COG1012	belongs to the aldehyde dehydrogenase family
CIG75_RS07230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CIG75_RS07235	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CIG75_RS07240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CIG75_RS07245	COG2323	membrane
CIG75_RS07250	COG0702	epimerase
CIG75_RS07325	COG0523	cobalamin synthesis protein
CIG75_RS07340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CIG75_RS07345	COG1361	Conserved repeat domain
CIG75_RS07365	COG0626	cystathionine gamma-synthase activity
CIG75_RS07375	COG1132	(ABC) transporter
CIG75_RS07380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CIG75_RS07395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CIG75_RS07400	COG1801	Protein of unknown function DUF72
CIG75_RS07410	COG1959	2 iron, 2 sulfur cluster binding
CIG75_RS07430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CIG75_RS07440	COG1024	Enoyl-CoA hydratase
CIG75_RS07445	COG0318	PFAM AMP-dependent synthetase and ligase
CIG75_RS07455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIG75_RS07470	COG1253	flavin adenine dinucleotide binding
CIG75_RS07475	COG0598	Magnesium transport protein CorA
CIG75_RS07525	COG1132	(ABC) transporter
CIG75_RS07530	COG1132	(ABC) transporter
CIG75_RS07535	COG2827	Endonuclease containing a URI domain
CIG75_RS07545	COG0387	Pfam Sodium calcium exchanger
CIG75_RS07550	COG0741	lytic transglycosylase activity
CIG75_RS07560	COG1757	Na H antiporter
CIG75_RS07585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CIG75_RS07590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CIG75_RS07595	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CIG75_RS07595	COG1605	Chorismate mutase
CIG75_RS07615	COG2197	response regulator
CIG75_RS07645	COG3278	Belongs to the heme-copper respiratory oxidase family
CIG75_RS07650	COG1376	ErfK ybiS ycfS ynhG family protein
CIG75_RS07655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CIG75_RS07655	COG2199	diguanylate cyclase activity
CIG75_RS07660	COG0123	including yeast histone deacetylase and acetoin utilization protein
CIG75_RS07665	COG0517	IMP dehydrogenase activity
CIG75_RS07670	COG0454	-acetyltransferase
CIG75_RS07675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CIG75_RS07680	COG1842	Phage shock protein A
CIG75_RS07690	COG0697	spore germination
CIG75_RS07705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CIG75_RS07705	COG5322	oxidoreductase activity
CIG75_RS07710	COG3118	belongs to the thioredoxin family
CIG75_RS07715	COG0322	excinuclease ABC activity
CIG75_RS07730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIG75_RS07735	COG0460	homoserine dehydrogenase
CIG75_RS07740	COG2009	succinate dehydrogenase
CIG75_RS07745	COG1053	succinate dehydrogenase
CIG75_RS07750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CIG75_RS07755	COG1406	Chemotaxis phosphatase CheX
CIG75_RS07760	COG2197	response regulator
CIG75_RS07785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CIG75_RS07790	COG1846	Transcriptional regulator
CIG75_RS07805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CIG75_RS07810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CIG75_RS07835	COG0544	peptidyl-prolyl cis-trans isomerase activity
CIG75_RS07840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CIG75_RS07845	COG1067	ATP-dependent peptidase activity
CIG75_RS07845	COG0470	DNA polymerase III
CIG75_RS07855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CIG75_RS07870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CIG75_RS07875	COG1116	anion transmembrane transporter activity
CIG75_RS07880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CIG75_RS07885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CIG75_RS07890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIG75_RS07895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CIG75_RS07895	COG1648	precorrin-2 dehydrogenase activity
CIG75_RS07900	COG0181	hydroxymethylbilane synthase activity
CIG75_RS07910	COG0113	porphobilinogen synthase activity
CIG75_RS07915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CIG75_RS07920	COG2233	PERMEase
CIG75_RS07925	COG2233	PERMEase
CIG75_RS07935	COG0564	pseudouridine synthase activity
CIG75_RS07960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIG75_RS07970	COG1388	LysM domain
CIG75_RS07985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIG75_RS07995	COG0791	NLP P60 protein
CIG75_RS08000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIG75_RS08010	COG1136	(ABC) transporter
CIG75_RS08020	COG0525	valine-tRNA ligase activity
CIG75_RS08035	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CIG75_RS08040	COG3584	3D domain protein
CIG75_RS08040	COG3583	domain protein
CIG75_RS08055	COG1027	Aspartate ammonia-lyase
CIG75_RS08060	COG0424	maF-like protein
CIG75_RS08070	COG1077	Cell shape determining protein MreB Mrl
CIG75_RS08075	COG1792	Involved in formation and maintenance of cell shape
CIG75_RS08085	COG0768	penicillin binding
CIG75_RS08090	COG0850	regulation of cytokinetic process
CIG75_RS08095	COG2894	cell division
CIG75_RS08110	COG1530	ribonuclease E activity
CIG75_RS08115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CIG75_RS08135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CIG75_RS08145	COG0730	response to heat
CIG75_RS08155	COG1619	proteins homologs of microcin C7 resistance protein MccF
CIG75_RS08160	COG1408	metallophosphoesterase
CIG75_RS08170	COG1459	type II secretion system
CIG75_RS08175	COG4537	Required for transformation and DNA binding
CIG75_RS08210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CIG75_RS08215	COG0367	asparagine synthase
CIG75_RS08220	COG4492	Belongs to the UPF0735 family
CIG75_RS08250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CIG75_RS08255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CIG75_RS08260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIG75_RS08265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CIG75_RS08280	COG0006	proline dipeptidase activity
CIG75_RS08285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CIG75_RS08300	COG2223	nitrite transmembrane transporter activity
CIG75_RS08315	COG0697	spore germination
CIG75_RS08340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CIG75_RS08345	COG0314	molybdopterin synthase activity
CIG75_RS08350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CIG75_RS08355	COG0315	cyclic pyranopterin monophosphate synthase activity
CIG75_RS08360	COG0521	Mo-molybdopterin cofactor biosynthetic process
CIG75_RS08375	COG0463	Glycosyl transferase, family 2
CIG75_RS08385	COG3858	chitin binding
CIG75_RS08400	COG3290	protein histidine kinase activity
CIG75_RS08400	COG3829	transcription factor binding
CIG75_RS08410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CIG75_RS08415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CIG75_RS08420	COG0022	dehydrogenase e1 component
CIG75_RS08425	COG0508	dehydrogenase complex catalyzes the overall conversion of
CIG75_RS08430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CIG75_RS08435	COG0321	lipoyl(octanoyl) transferase activity
CIG75_RS08450	COG0180	Tryptophanyl-tRNA synthetase
CIG75_RS08455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_RS08455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_RS08460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_RS08460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_RS08465	COG0346	lactoylglutathione lyase activity
CIG75_RS08470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CIG75_RS08480	COG2195	Cleaves the N-terminal amino acid of tripeptides
CIG75_RS08485	COG0840	transmembrane signaling receptor activity
CIG75_RS08500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CIG75_RS08505	COG0697	spore germination
CIG75_RS08520	COG2195	Cleaves the N-terminal amino acid of tripeptides
CIG75_RS08535	COG0494	nUDIX hydrolase
CIG75_RS08540	COG1379	DNA repair
CIG75_RS08545	COG1300	Membrane
CIG75_RS08555	COG0735	belongs to the Fur family
CIG75_RS08560	COG0686	Belongs to the AlaDH PNT family
CIG75_RS08570	COG4974	Belongs to the 'phage' integrase family
CIG75_RS08575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CIG75_RS08590	COG1686	Belongs to the peptidase S11 family
CIG75_RS08595	COG0514	ATP-dependent DNA helicase (RecQ)
CIG75_RS08615	COG0840	transmembrane signaling receptor activity
CIG75_RS08620	COG2217	Heavy metal translocating P-type atpase
CIG75_RS08685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIG75_RS08690	COG0446	pyridine nucleotide-disulphide oxidoreductase
CIG75_RS08700	COG2172	sigma factor antagonist activity
CIG75_RS08705	COG1191	sigma factor activity
CIG75_RS08715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIG75_RS08730	COG0697	spore germination
CIG75_RS08740	COG3409	Peptidoglycan-binding domain 1 protein
CIG75_RS08740	COG3773	Cell wall hydrolase
CIG75_RS08745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIG75_RS08750	COG1686	Belongs to the peptidase S11 family
CIG75_RS08755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CIG75_RS08760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CIG75_RS08760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CIG75_RS08770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_RS08770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_RS08775	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CIG75_RS08785	COG0477	Major facilitator Superfamily
CIG75_RS08790	COG1994	Peptidase M50
CIG75_RS08795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CIG75_RS08800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CIG75_RS08810	COG3874	Sporulation protein YtfJ
CIG75_RS08815	COG1686	Belongs to the peptidase S11 family
CIG75_RS08820	COG2715	membrane protein required for spore maturation
CIG75_RS08825	COG0700	Nucleoside recognition
CIG75_RS08835	COG1187	pseudouridine synthase activity
CIG75_RS08845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIG75_RS08850	COG1333	cytochrome c biogenesis protein
CIG75_RS08855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CIG75_RS08860	COG0745	RESPONSE REGULATOR receiver
CIG75_RS08865	COG5002	protein histidine kinase activity
CIG75_RS08875	COG1832	CoA-binding protein
CIG75_RS08885	COG0352	thiamine-phosphate diphosphorylase activity
CIG75_RS08895	COG2022	thiamine diphosphate biosynthetic process
CIG75_RS08900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CIG75_RS08915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIG75_RS08930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CIG75_RS08935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CIG75_RS08940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIG75_RS08960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CIG75_RS08995	COG0326	Molecular chaperone. Has ATPase activity
CIG75_RS09000	COG0681	Belongs to the peptidase S26 family
CIG75_RS09005	COG0431	NADPH-dependent FMN reductase
CIG75_RS09035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIG75_RS09045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CIG75_RS09050	COG0312	modulator of DNA gyrase
CIG75_RS09060	COG2814	Major facilitator Superfamily
CIG75_RS09075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CIG75_RS09090	COG0791	NLP P60 protein
CIG75_RS09090	COG1388	LysM domain
CIG75_RS09095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIG75_RS09100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIG75_RS09105	COG0300	oxidoreductase activity
CIG75_RS09115	COG1278	Cold shock
CIG75_RS09120	COG0726	polysaccharide deacetylase
CIG75_RS09130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CIG75_RS09135	COG0302	gtp cyclohydrolase
CIG75_RS09150	COG0705	Rhomboid family
CIG75_RS09150	COG0457	Tetratricopeptide repeat
CIG75_RS09155	COG0840	transmembrane signaling receptor activity
CIG75_RS09165	COG3091	SprT-like family
CIG75_RS09180	COG0210	DNA helicase
CIG75_RS09215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CIG75_RS09225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CIG75_RS09230	COG0438	transferase activity, transferring glycosyl groups
CIG75_RS09235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIG75_RS09245	COG3858	chitin binding
CIG75_RS09255	COG4637	Psort location Cytoplasmic, score
CIG75_RS09260	COG1609	Transcriptional regulator
CIG75_RS09265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CIG75_RS09270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CIG75_RS09280	COG2707	UPF0756 membrane protein
CIG75_RS09285	COG1809	phosphosulfolactate synthase activity
CIG75_RS09290	COG2814	Major facilitator Superfamily
CIG75_RS09295	COG0626	cystathionine gamma-synthase activity
CIG75_RS09300	COG0626	cystathionine gamma-synthase activity
CIG75_RS09305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CIG75_RS09315	COG2339	peptidase activity
CIG75_RS09325	COG2959	enzyme of heme biosynthesis
CIG75_RS09330	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_RS09345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CIG75_RS09360	COG1304	FMN binding
CIG75_RS09400	COG1160	GTP binding
CIG75_RS09405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CIG75_RS09410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CIG75_RS09415	COG0509	glycine decarboxylation via glycine cleavage system
CIG75_RS09420	COG0095	Lipoate-protein ligase
CIG75_RS09425	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CIG75_RS09435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CIG75_RS09455	COG4974	Belongs to the 'phage' integrase family
CIG75_RS09570	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_RS09590	COG2304	oxidoreductase activity
CIG75_RS09600	COG3695	enzyme binding
CIG75_RS09605	COG0753	catalase activity
CIG75_RS09615	COG2155	Conserved Protein
CIG75_RS09635	COG2226	methyltransferase
CIG75_RS09640	COG0163	prenyltransferase activity
CIG75_RS09645	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CIG75_RS09655	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CIG75_RS09665	COG0105	UTP biosynthetic process
CIG75_RS09675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CIG75_RS09725	COG0438	transferase activity, transferring glycosyl groups
CIG75_RS09735	COG0564	pseudouridine synthase activity
CIG75_RS09745	COG0456	acetyltransferase
CIG75_RS09750	COG2855	membrane
CIG75_RS09765	COG2329	Antibiotic biosynthesis monooxygenase
CIG75_RS09780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIG75_RS09810	COG0456	acetyltransferase
CIG75_RS09825	COG0589	response to stress
CIG75_RS09830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CIG75_RS09835	COG3383	formate dehydrogenase (NAD+) activity
CIG75_RS09840	COG2427	Protein of unknown function (DUF1641)
CIG75_RS09855	COG0028	Belongs to the TPP enzyme family
CIG75_RS09855	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CIG75_RS09860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CIG75_RS09865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CIG75_RS09870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CIG75_RS09885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CIG75_RS09895	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CIG75_RS09900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CIG75_RS09920	COG1199	ATP-dependent helicase activity
CIG75_RS09920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CIG75_RS09930	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CIG75_RS09935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CIG75_RS09940	COG1793	dna ligase
CIG75_RS09945	COG3285	dna ligase
CIG75_RS09945	COG1793	dna ligase
CIG75_RS09950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CIG75_RS09955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CIG75_RS09960	COG0235	Class ii aldolase
CIG75_RS09965	COG0402	S-adenosylhomocysteine deaminase activity
CIG75_RS09975	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CIG75_RS09990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CIG75_RS10000	COG0017	Asparaginyl-tRNA synthetase
CIG75_RS10005	COG3935	DnaD domain protein
CIG75_RS10015	COG0488	(ABC) transporter
CIG75_RS10035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CIG75_RS10045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CIG75_RS10050	COG1131	(ABC) transporter
CIG75_RS10065	COG1595	DNA-templated transcription, initiation
CIG75_RS10075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CIG75_RS10080	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CIG75_RS10085	COG0789	Transcriptional regulator
CIG75_RS10090	COG0174	glutamine synthetase
CIG75_RS10095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CIG75_RS10100	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS10105	COG0318	PFAM AMP-dependent synthetase and ligase
CIG75_RS10115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIG75_RS10130	COG0740	serine-type endopeptidase activity
CIG75_RS10140	COG0411	ABC transporter
CIG75_RS10150	COG0559	Belongs to the binding-protein-dependent transport system permease family
CIG75_RS10180	COG2247	cell wall binding repeat
CIG75_RS10180	COG2385	sporulation resulting in formation of a cellular spore
CIG75_RS10190	COG2188	Transcriptional regulator
CIG75_RS10195	COG2971	BadF BadG BcrA BcrD
CIG75_RS10200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CIG75_RS10205	COG1472	Belongs to the glycosyl hydrolase 3 family
CIG75_RS10210	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CIG75_RS10215	COG3876	Protein conserved in bacteria
CIG75_RS10220	COG1653	transport
CIG75_RS10225	COG1175	transmembrane transport
CIG75_RS10230	COG0395	ABC-type sugar transport system, permease component
CIG75_RS10235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CIG75_RS10240	COG0363	glucosamine-6-phosphate deaminase activity
CIG75_RS10260	COG4974	Belongs to the 'phage' integrase family
CIG75_RS10265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CIG75_RS10295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CIG75_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS10360	COG3483	tryptophan 2,3-dioxygenase activity
CIG75_RS10370	COG2259	Doxx family
CIG75_RS10395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CIG75_RS10400	COG3706	GGDEF domain
CIG75_RS10420	COG0010	Belongs to the arginase family
CIG75_RS10425	COG1228	amidohydrolase
CIG75_RS10435	COG2986	histidine ammonia-lyase
CIG75_RS10450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CIG75_RS10450	COG0167	dihydroorotate dehydrogenase activity
CIG75_RS10455	COG0493	'glutamate synthase
CIG75_RS10505	COG1741	Belongs to the pirin family
CIG75_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS10535	COG3321	synthase
CIG75_RS10535	COG0300	oxidoreductase activity
CIG75_RS10535	COG0318	PFAM AMP-dependent synthetase and ligase
CIG75_RS10535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIG75_RS10550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CIG75_RS10555	COG1132	(ABC) transporter
CIG75_RS10560	COG0464	growth
CIG75_RS10600	COG0464	growth
CIG75_RS10660	COG2070	2-Nitropropane dioxygenase
CIG75_RS10670	COG0477	Major facilitator Superfamily
CIG75_RS10730	COG0482	sulfurtransferase activity
CIG75_RS10735	COG1309	transcriptional regulator
CIG75_RS10740	COG2409	Drug exporters of the RND superfamily
CIG75_RS10740	COG1033	growth of symbiont in host cell
CIG75_RS10825	COG1923	regulation of RNA biosynthetic process
CIG75_RS10830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CIG75_RS10835	COG2136	Putative SAM-dependent methyltransferase
CIG75_RS10835	COG2521	methyltransferase
CIG75_RS10840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CIG75_RS10845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CIG75_RS10855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIG75_RS10865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIG75_RS10875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CIG75_RS10880	COG0287	Prephenate dehydrogenase
CIG75_RS10885	COG0159	tryptophan synthase activity
CIG75_RS10890	COG0133	tryptophan synthase activity
CIG75_RS10895	COG0135	phosphoribosylanthranilate isomerase activity
CIG75_RS10900	COG0134	indole-3-glycerol-phosphate synthase activity
CIG75_RS10905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CIG75_RS10915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CIG75_RS10920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CIG75_RS10925	COG1363	Peptidase, m42
CIG75_RS10930	COG1363	Peptidase, m42
CIG75_RS11090	COG0714	Associated with various cellular activities
CIG75_RS11160	COG2205	protein histidine kinase activity
CIG75_RS11270	COG1222	aaa ATPase
CIG75_RS11280	COG4208	sulfate ABC transporter
CIG75_RS11285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CIG75_RS11290	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CIG75_RS11300	COG2226	methyltransferase
CIG75_RS11320	COG3437	response regulator, receiver
CIG75_RS11320	COG0784	Response regulator, receiver
CIG75_RS11340	COG1233	COG1233 Phytoene dehydrogenase and related
CIG75_RS11350	COG0617	tRNA 3'-terminal CCA addition
CIG75_RS11355	COG1803	Methylglyoxal synthase
CIG75_RS11360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CIG75_RS11365	COG1694	Mazg nucleotide pyrophosphohydrolase
CIG75_RS11370	COG3314	Sporulation integral membrane protein YlbJ
CIG75_RS11375	COG1968	undecaprenyl-diphosphatase activity
CIG75_RS11380	COG3949	Membrane
CIG75_RS11385	COG0586	Pfam SNARE associated Golgi protein
CIG75_RS11395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CIG75_RS11410	COG2010	Cytochrome c
CIG75_RS11410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIG75_RS11415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CIG75_RS11430	COG5582	Belongs to the UPF0302 family
CIG75_RS11440	COG1061	Type III restriction enzyme res subunit
CIG75_RS11450	COG2112	serine threonine protein kinase
CIG75_RS11465	COG0688	phosphatidylethanolamine metabolic process
CIG75_RS11470	COG0384	phenazine biosynthesis protein PhzF
CIG75_RS11475	COG0189	ligase activity
CIG75_RS11480	COG0189	ligase activity
CIG75_RS11505	COG0523	cobalamin synthesis protein
CIG75_RS11515	COG0583	DNA-binding transcription factor activity
CIG75_RS11520	COG0531	amino acid
CIG75_RS11545	COG0613	PHP domain protein
CIG75_RS11555	COG2359	stage V sporulation protein S
CIG75_RS11560	COG1692	metallophosphoesterase
CIG75_RS11570	COG1418	mRNA catabolic process
CIG75_RS11590	COG1546	Belongs to the CinA family
CIG75_RS11590	COG1058	Belongs to the CinA family
CIG75_RS11595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CIG75_RS11600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIG75_RS11620	COG1426	Protein conserved in bacteria
CIG75_RS11635	COG0477	Major facilitator Superfamily
CIG75_RS11670	COG1079	Belongs to the binding-protein-dependent transport system permease family
CIG75_RS11675	COG4603	Belongs to the binding-protein-dependent transport system permease family
CIG75_RS11680	COG3845	ABC transporter
CIG75_RS11685	COG1744	ABC transporter substrate-binding protein PnrA-like
CIG75_RS11690	COG2188	Transcriptional regulator
CIG75_RS11695	COG1674	ftsk spoiiie
CIG75_RS11695	COG4980	gas vesicle protein
CIG75_RS11705	COG0740	serine-type endopeptidase activity
CIG75_RS11710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CIG75_RS11715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CIG75_RS11720	COG0527	aspartate kinase activity
CIG75_RS11725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CIG75_RS11730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CIG75_RS11735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CIG75_RS11740	COG1873	PFAM PRC-barrel domain
CIG75_RS11745	COG0612	Peptidase, M16
CIG75_RS11750	COG0726	polysaccharide deacetylase
CIG75_RS11760	COG1185	polyribonucleotide nucleotidyltransferase activity
CIG75_RS11765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CIG75_RS11780	COG0196	riboflavin kinase activity
CIG75_RS11785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CIG75_RS11790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CIG75_RS11800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CIG75_RS11815	COG0195	Participates in both transcription termination and antitermination
CIG75_RS11820	COG0779	Required for maturation of 30S ribosomal subunits
CIG75_RS11825	COG2176	DNA-directed DNA polymerase activity
CIG75_RS11830	COG0463	Glycosyl transferase, family 2
CIG75_RS11835	COG0442	prolyl-tRNA aminoacylation
CIG75_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS11845	COG0531	amino acid
CIG75_RS11850	COG0584	glycerophosphoryl diester phosphodiesterase
CIG75_RS11855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CIG75_RS11870	COG4589	Belongs to the CDS family
CIG75_RS11875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CIG75_RS11880	COG0233	cytoplasmic translational termination
CIG75_RS11885	COG0528	UMP kinase activity
CIG75_RS11890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CIG75_RS11895	COG0052	Belongs to the universal ribosomal protein uS2 family
CIG75_RS11920	COG1191	sigma factor activity
CIG75_RS11930	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CIG75_RS11935	COG1776	CheC inhibitor of MCP methylation
CIG75_RS11940	COG0835	chemotaxis
CIG75_RS11945	COG0643	Histidine kinase
CIG75_RS11945	COG2198	Histidine kinase
CIG75_RS11950	COG2201	protein-glutamate methylesterase activity
CIG75_RS11955	COG0455	bacterial-type flagellum organization
CIG75_RS11960	COG1419	protein localization to endoplasmic reticulum
CIG75_RS11965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CIG75_RS11970	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CIG75_RS11975	COG1684	flagellar biosynthetic protein fliR
CIG75_RS11980	COG1987	bacterial-type flagellum assembly
CIG75_RS11985	COG1338	Plays a role in the flagellum-specific transport system
CIG75_RS11995	COG2201	protein-glutamate methylesterase activity
CIG75_RS12000	COG1776	CheC inhibitor of MCP methylation
CIG75_RS12000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CIG75_RS12005	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CIG75_RS12020	COG4786	Flagellar basal body rod
CIG75_RS12030	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CIG75_RS12050	COG1157	protein secretion by the type III secretion system
CIG75_RS12055	COG1317	bacterial-type flagellum organization
CIG75_RS12060	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CIG75_RS12075	COG1558	bacterial-type flagellum-dependent cell motility
CIG75_RS12080	COG1815	bacterial-type flagellum-dependent cell motility
CIG75_RS12085	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CIG75_RS12090	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CIG75_RS12095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CIG75_RS12100	COG4974	Belongs to the 'phage' integrase family
CIG75_RS12105	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CIG75_RS12110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIG75_RS12115	COG0758	DNA mediated transformation
CIG75_RS12120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CIG75_RS12145	COG2814	Major facilitator Superfamily
CIG75_RS12195	COG0792	nuclease activity
CIG75_RS12200	COG2257	FlhB HrpN YscU SpaS Family
CIG75_RS12210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CIG75_RS12220	COG0681	Belongs to the peptidase S26 family
CIG75_RS12225	COG0335	large ribosomal subunit rRNA binding
CIG75_RS12235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CIG75_RS12240	COG1376	ErfK ybiS ycfS ynhG family protein
CIG75_RS12295	COG0336	Belongs to the RNA methyltransferase TrmD family
CIG75_RS12310	COG1837	Belongs to the UPF0109 family
CIG75_RS12315	COG0228	four-way junction DNA binding
CIG75_RS12320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CIG75_RS12330	COG0552	protein localization to endoplasmic reticulum
CIG75_RS12335	COG1196	nuclear chromosome segregation
CIG75_RS12345	COG0571	ribonuclease III activity
CIG75_RS12350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CIG75_RS12355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CIG75_RS12360	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS12365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CIG75_RS12375	COG0416	fatty acid biosynthetic process
CIG75_RS12385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CIG75_RS12395	COG1323	Belongs to the UPF0348 family
CIG75_RS12400	COG3480	Lon protease (S16) C-terminal proteolytic domain
CIG75_RS12405	COG1752	Esterase of the alpha-beta hydrolase superfamily
CIG75_RS12410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CIG75_RS12415	COG0742	ribosomal rna small subunit methyltransferase
CIG75_RS12425	COG1361	Conserved repeat domain
CIG75_RS12440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CIG75_RS12445	COG1760	l-serine dehydratase
CIG75_RS12450	COG1760	l-serine dehydratase
CIG75_RS12455	COG1461	Dihydroxyacetone kinase
CIG75_RS12460	COG1302	Protein conserved in bacteria
CIG75_RS12465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CIG75_RS12475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CIG75_RS12480	COG1162	GTPase activity
CIG75_RS12485	COG2815	serine threonine protein kinase
CIG75_RS12485	COG0515	serine threonine protein kinase
CIG75_RS12490	COG0631	protein serine/threonine phosphatase activity
CIG75_RS12495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CIG75_RS12500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIG75_RS12500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CIG75_RS12510	COG0242	peptide deformylase activity
CIG75_RS12515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CIG75_RS12520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CIG75_RS12525	COG1758	RNA polymerase activity
CIG75_RS12535	COG2052	Domain of unknown function (DUF370)
CIG75_RS12540	COG1561	YicC-like family, N-terminal region
CIG75_RS12545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CIG75_RS12550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CIG75_RS12570	COG1131	(ABC) transporter
CIG75_RS12585	COG0438	transferase activity, transferring glycosyl groups
CIG75_RS12590	COG0189	ligase activity
CIG75_RS12600	COG2382	esterase
CIG75_RS12620	COG0247	lactate metabolic process
CIG75_RS12625	COG0277	FAD linked oxidase domain protein
CIG75_RS12630	COG2267	carboxylic ester hydrolase activity
CIG75_RS12880	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CIG75_RS12900	COG0305	Participates in initiation and elongation during chromosome replication
CIG75_RS12905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CIG75_RS12915	COG0210	DNA helicase
CIG75_RS12975	COG1396	sequence-specific DNA binding
CIG75_RS13010	COG0284	orotidine-5'-phosphate decarboxylase activity
CIG75_RS13015	COG0167	dihydroorotate dehydrogenase activity
CIG75_RS13020	COG0543	2 iron, 2 sulfur cluster binding
CIG75_RS13025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CIG75_RS13035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CIG75_RS13040	COG0540	Belongs to the ATCase OTCase family
CIG75_RS13050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CIG75_RS13055	COG0564	pseudouridine synthase activity
CIG75_RS13060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CIG75_RS13065	COG1404	Belongs to the peptidase S8 family
CIG75_RS13175	COG3599	regulation of cell shape
CIG75_RS13190	COG1799	cell septum assembly
CIG75_RS13195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CIG75_RS13205	COG1873	PFAM PRC-barrel domain
CIG75_RS13210	COG1191	sigma factor activity
CIG75_RS13215	COG1191	sigma factor activity
CIG75_RS13240	COG2801	Transposase and inactivated derivatives
CIG75_RS13270	COG0644	oxidoreductase
CIG75_RS13290	COG0477	Major facilitator Superfamily
CIG75_RS13295	COG3251	PFAM MbtH domain protein
CIG75_RS13300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CIG75_RS13305	COG3433	isochorismatase activity
CIG75_RS13305	COG1535	isochorismatase
CIG75_RS13310	COG1021	2,3-dihydroxybenzoate-AMP ligase
CIG75_RS13315	COG1169	isochorismate synthase
CIG75_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS13450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CIG75_RS13455	COG0849	cell division
CIG75_RS13460	COG3856	small basic protein
CIG75_RS13465	COG3879	Bacterial protein of unknown function (DUF881)
CIG75_RS13480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CIG75_RS13485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CIG75_RS13490	COG0772	Belongs to the SEDS family
CIG75_RS13495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CIG75_RS13500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CIG75_RS13505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CIG75_RS13510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CIG75_RS13515	COG0768	penicillin binding
CIG75_RS13520	COG0768	penicillin binding
CIG75_RS13530	COG0275	rRNA processing
CIG75_RS13535	COG2001	Belongs to the MraZ family
CIG75_RS13540	COG1902	pentaerythritol trinitrate reductase activity
CIG75_RS13545	COG1733	regulation of RNA biosynthetic process
CIG75_RS13565	COG4166	transmembrane transport
CIG75_RS13570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CIG75_RS13575	COG1024	Enoyl-CoA hydratase
CIG75_RS13580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CIG75_RS13585	COG0511	ligase activity, forming carbon-carbon bonds
CIG75_RS13590	COG0439	Biotin carboxylase
CIG75_RS13600	COG2267	carboxylic ester hydrolase activity
CIG75_RS13605	COG1028	Short-chain dehydrogenase reductase Sdr
CIG75_RS13610	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CIG75_RS13615	COG0316	Belongs to the HesB IscA family
CIG75_RS13635	COG1217	gtp-binding protein TYPA
CIG75_RS13640	COG4149	molybdate abc transporter
CIG75_RS13645	COG0725	ABC transporter, periplasmic molybdate-binding protein
CIG75_RS13650	COG0488	(ABC) transporter
CIG75_RS13655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CIG75_RS13660	COG2153	protein acetylation
CIG75_RS13670	COG0644	oxidoreductase
CIG75_RS13675	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CIG75_RS13680	COG2086	electron transfer activity
CIG75_RS13710	COG2199	diguanylate cyclase activity
CIG75_RS13710	COG2203	Gaf domain
CIG75_RS13720	COG4166	transmembrane transport
CIG75_RS13730	COG4166	transmembrane transport
CIG75_RS13760	COG0488	(ABC) transporter
CIG75_RS13830	COG0750	zinc metalloprotease
CIG75_RS13835	COG0497	DNA recombination
CIG75_RS13840	COG1438	arginine binding
CIG75_RS13845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CIG75_RS13850	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CIG75_RS13855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CIG75_RS13870	COG1722	exodeoxyribonuclease VII activity
CIG75_RS13880	COG0492	ferredoxin-NADP+ reductase activity
CIG75_RS13885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CIG75_RS13890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CIG75_RS13905	COG1302	Protein conserved in bacteria
CIG75_RS13910	COG0439	Biotin carboxylase
CIG75_RS13915	COG0511	ligase activity, forming carbon-carbon bonds
CIG75_RS13955	COG3854	ATPases associated with a variety of cellular activities
CIG75_RS13960	COG1671	Belongs to the UPF0178 family
CIG75_RS13980	COG2226	methyltransferase
CIG75_RS13985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CIG75_RS14005	COG0494	nUDIX hydrolase
CIG75_RS14020	COG2815	serine threonine protein kinase
CIG75_RS14020	COG0515	serine threonine protein kinase
CIG75_RS14030	COG0454	-acetyltransferase
CIG75_RS14035	COG4224	UPF0291 protein
CIG75_RS14040	COG0301	tRNA thio-modification
CIG75_RS14055	COG1307	EDD domain protein, DegV family
CIG75_RS14065	COG0740	serine-type endopeptidase activity
CIG75_RS14070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CIG75_RS14115	COG2081	HI0933 family
CIG75_RS14120	COG2814	Major facilitator Superfamily
CIG75_RS14125	COG3442	glutamine amidotransferase
CIG75_RS14145	COG1376	ErfK ybiS ycfS ynhG family protein
CIG75_RS14155	COG0512	Glutamine amidotransferase of anthranilate synthase
CIG75_RS14160	COG1073	alpha beta
CIG75_RS14190	COG1192	Involved in chromosome partitioning
CIG75_RS14220	COG3507	Belongs to the glycosyl hydrolase 43 family
CIG75_RS14220	COG2382	esterase
CIG75_RS14220	COG3693	PFAM glycoside hydrolase, family 10
CIG75_RS14230	COG0840	transmembrane signaling receptor activity
CIG75_RS14240	COG0427	acetyl-CoA hydrolase
CIG75_RS14245	COG3279	Response regulator of the LytR AlgR family
CIG75_RS14255	COG1285	pathogenesis
CIG75_RS14265	COG1132	(ABC) transporter
CIG75_RS14285	COG3714	YhhN family
CIG75_RS14305	COG2233	PERMEase
CIG75_RS14310	COG0583	DNA-binding transcription factor activity
CIG75_RS14330	COG0640	Transcriptional regulator
CIG75_RS14345	COG0726	polysaccharide deacetylase
CIG75_RS14365	COG0697	spore germination
CIG75_RS14415	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CIG75_RS14485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CIG75_RS14490	COG0512	Glutamine amidotransferase of anthranilate synthase
CIG75_RS14495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CIG75_RS14500	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CIG75_RS14500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CIG75_RS14510	COG0826	peptidase U32
CIG75_RS14515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CIG75_RS14520	COG2755	lipolytic protein G-D-S-L family
CIG75_RS14525	COG1131	(ABC) transporter
CIG75_RS14530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CIG75_RS14535	COG0561	phosphatase activity
CIG75_RS14540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CIG75_RS14545	COG4122	O-methyltransferase activity
CIG75_RS14550	COG1215	transferase activity, transferring glycosyl groups
CIG75_RS14555	COG2268	Band 7 protein
CIG75_RS14570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CIG75_RS14590	COG0367	asparagine synthase
CIG75_RS14605	COG2801	Transposase and inactivated derivatives
CIG75_RS14615	COG1272	protein, Hemolysin III
CIG75_RS14630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CIG75_RS14635	COG2384	SAM-dependent methyltransferase
CIG75_RS14640	COG1960	acyl-CoA dehydrogenase activity
CIG75_RS14650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CIG75_RS14655	COG0358	DNA primase activity
CIG75_RS14660	COG0574	Belongs to the PEP-utilizing enzyme family
CIG75_RS14660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CIG75_RS14665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CIG75_RS14670	COG0517	IMP dehydrogenase activity
CIG75_RS14685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CIG75_RS14700	COG1381	Involved in DNA repair and RecF pathway recombination
CIG75_RS14710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CIG75_RS14720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CIG75_RS14725	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CIG75_RS14730	COG1480	7TM receptor with intracellular HD hydrolase
CIG75_RS14735	COG1702	phosphate starvation-inducible protein PhoH
CIG75_RS14755	COG4864	UPF0365 protein
CIG75_RS14760	COG1030	water channel activity
CIG75_RS14765	COG1610	YqeY-like protein
CIG75_RS14770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CIG75_RS14780	COG1283	sodium-dependent phosphate transmembrane transporter activity
CIG75_RS14785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CIG75_RS14790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CIG75_RS14795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CIG75_RS14800	COG2264	protein methyltransferase activity
CIG75_RS14810	COG0443	Heat shock 70 kDa protein
CIG75_RS14820	COG0459	protein refolding
CIG75_RS14825	COG1420	regulation of RNA biosynthetic process
CIG75_RS14840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIG75_RS14850	COG0481	GTPase activity
CIG75_RS14870	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_RS14885	COG0268	Binds directly to 16S ribosomal RNA
CIG75_RS14895	COG1466	dna polymerase III delta subunit
CIG75_RS14900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CIG75_RS14905	COG1252	NADH dehydrogenase
CIG75_RS14910	COG4294	response to UV
CIG75_RS14920	COG0640	Transcriptional regulator
CIG75_RS14925	COG5658	integral membrane protein
CIG75_RS14935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_RS14935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CIG75_RS14950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CIG75_RS14955	COG0647	UMP catabolic process
CIG75_RS14960	COG2096	Adenosyltransferase
CIG75_RS15085	COG1013	pyruvate-flavodoxin oxidoreductase activity
CIG75_RS15090	COG0674	pyruvate-flavodoxin oxidoreductase activity
CIG75_RS15090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CIG75_RS15095	COG0626	cystathionine gamma-synthase activity
CIG75_RS15100	COG3584	3D domain protein
CIG75_RS15120	COG1131	(ABC) transporter
CIG75_RS15130	COG2843	Capsule synthesis protein
CIG75_RS15150	COG0352	thiamine-phosphate diphosphorylase activity
CIG75_RS15155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CIG75_RS15165	COG0513	Belongs to the DEAD box helicase family
CIG75_RS15180	COG5577	PFAM Coat F domain
CIG75_RS15185	COG0584	glycerophosphoryl diester phosphodiesterase
CIG75_RS15190	COG1725	Transcriptional regulator
CIG75_RS15195	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CIG75_RS15195	COG0674	pyruvate-flavodoxin oxidoreductase activity
CIG75_RS15200	COG1013	pyruvate-flavodoxin oxidoreductase activity
CIG75_RS15220	COG0492	ferredoxin-NADP+ reductase activity
CIG75_RS15225	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CIG75_RS15235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_RS15260	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CIG75_RS15265	COG1363	Peptidase, m42
CIG75_RS15280	COG3377	Domain of unknown function (DUF1805)
CIG75_RS15295	COG0586	Pfam SNARE associated Golgi protein
CIG75_RS15310	COG3639	organic phosphonate transmembrane transporter activity
CIG75_RS15315	COG3639	organic phosphonate transmembrane transporter activity
CIG75_RS15320	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CIG75_RS15330	COG0840	transmembrane signaling receptor activity
CIG75_RS15335	COG0561	phosphatase activity
CIG75_RS15340	COG1078	dGTPase activity
CIG75_RS15350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CIG75_RS15355	COG0628	permease
CIG75_RS15360	COG0628	permease
CIG75_RS15370	COG2211	Major facilitator Superfamily
CIG75_RS15390	COG1013	pyruvate-flavodoxin oxidoreductase activity
CIG75_RS15395	COG0674	pyruvate-flavodoxin oxidoreductase activity
CIG75_RS15395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CIG75_RS15405	COG0297	glycogen (starch) synthase activity
CIG75_RS15410	COG1388	LysM domain
CIG75_RS15410	COG3584	3D domain protein
CIG75_RS15415	COG1982	Orn Lys Arg decarboxylase major
CIG75_RS15435	COG2814	Major facilitator Superfamily
CIG75_RS15440	COG1126	abc transporter atp-binding protein
CIG75_RS15445	COG0765	amino acid transport
CIG75_RS15450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CIG75_RS15460	COG1368	sulfuric ester hydrolase activity
CIG75_RS15465	COG0697	spore germination
CIG75_RS15470	COG0612	Peptidase, M16
CIG75_RS15475	COG1393	Belongs to the ArsC family
CIG75_RS15480	COG1832	CoA-binding protein
CIG75_RS15495	COG2357	RelA SpoT domain protein
CIG75_RS15500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CIG75_RS15505	COG0006	proline dipeptidase activity
CIG75_RS15515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CIG75_RS15550	COG1164	Oligoendopeptidase f
CIG75_RS15565	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CIG75_RS15570	COG0791	NLP P60 protein
CIG75_RS15605	COG3546	catalase activity
CIG75_RS15615	COG3118	belongs to the thioredoxin family
CIG75_RS15620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CIG75_RS15650	COG3033	Beta-eliminating lyase
CIG75_RS15655	COG3829	transcription factor binding
CIG75_RS15655	COG3290	protein histidine kinase activity
CIG75_RS15665	COG0561	phosphatase activity
CIG75_RS15670	COG5002	protein histidine kinase activity
CIG75_RS15695	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CIG75_RS15700	COG1607	acyl-coa hydrolase
CIG75_RS15705	COG0346	lactoylglutathione lyase activity
CIG75_RS15715	COG3340	Belongs to the peptidase S51 family
CIG75_RS15720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_RS15735	COG3290	protein histidine kinase activity
CIG75_RS15735	COG0840	transmembrane signaling receptor activity
CIG75_RS15755	COG0579	oxidoreductase
CIG75_RS15765	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CIG75_RS15770	COG0235	Class ii aldolase
CIG75_RS15775	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CIG75_RS15780	COG1850	ribulose-bisphosphate carboxylase activity
CIG75_RS15785	COG0436	Aminotransferase
CIG75_RS15800	COG0640	Transcriptional regulator
CIG75_RS15815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CIG75_RS15820	COG0785	Cytochrome C biogenesis protein
CIG75_RS15835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CIG75_RS15840	COG0584	glycerophosphoryl diester phosphodiesterase
CIG75_RS15850	COG0586	Pfam SNARE associated Golgi protein
CIG75_RS15865	COG5002	protein histidine kinase activity
CIG75_RS15870	COG0772	Belongs to the SEDS family
CIG75_RS15885	COG1213	nucleotidyl transferase
CIG75_RS15900	COG1956	GAF domain-containing protein
CIG75_RS15905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CIG75_RS15920	COG0720	synthase
CIG75_RS15925	COG0602	queuosine metabolic process
CIG75_RS15930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CIG75_RS15975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIG75_RS15980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CIG75_RS15990	COG0612	Peptidase, M16
CIG75_RS15995	COG0612	Peptidase, M16
CIG75_RS16015	COG1252	NADH dehydrogenase
CIG75_RS16025	COG2340	Cysteine-rich secretory protein family
CIG75_RS16030	COG0583	DNA-binding transcription factor activity
CIG75_RS16035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIG75_RS16050	COG2222	sugar isomerase
CIG75_RS16055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CIG75_RS16055	COG1213	nucleotidyl transferase
CIG75_RS16080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_RS16080	COG1703	isobutyryl-CoA mutase activity
CIG75_RS16080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CIG75_RS16085	COG1309	transcriptional regulator
CIG75_RS16115	COG1575	Belongs to the MenA family. Type 1 subfamily
CIG75_RS16120	COG0671	phosphoesterase, PA-phosphatase related
CIG75_RS16135	COG1122	ATPase activity
CIG75_RS16140	COG1122	ATPase activity
CIG75_RS16145	COG1960	acyl-CoA dehydrogenase activity
CIG75_RS16150	COG0183	Belongs to the thiolase family
CIG75_RS16155	COG1024	Enoyl-CoA hydratase
CIG75_RS16155	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_RS16160	COG1388	LysM domain
CIG75_RS16160	COG3584	3D domain protein
CIG75_RS16180	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CIG75_RS16200	COG1098	S1 RNA binding domain
CIG75_RS16205	COG3842	ATPase activity
CIG75_RS16215	COG5002	protein histidine kinase activity
CIG75_RS16230	COG4166	transmembrane transport
CIG75_RS16235	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CIG75_RS16260	COG1363	Peptidase, m42
CIG75_RS16280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CIG75_RS16300	COG1316	TRANSCRIPTIONal
CIG75_RS16305	COG0537	adenosine 5'-monophosphoramidase activity
CIG75_RS16360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CIG75_RS16370	COG0179	Fumarylacetoacetate (FAA) hydrolase
CIG75_RS16375	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CIG75_RS16385	COG0564	pseudouridine synthase activity
CIG75_RS16395	COG0583	DNA-binding transcription factor activity
CIG75_RS16400	COG0372	Belongs to the citrate synthase family
CIG75_RS16410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CIG75_RS16415	COG2211	Major facilitator Superfamily
CIG75_RS16420	COG2264	protein methyltransferase activity
CIG75_RS16430	COG0124	histidyl-tRNA synthetase
CIG75_RS16470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CIG75_RS16475	COG2086	electron transfer activity
CIG75_RS16480	COG1309	transcriptional regulator
CIG75_RS16495	COG0475	glutathione-regulated potassium exporter activity
CIG75_RS16510	COG0840	transmembrane signaling receptor activity
CIG75_RS16515	COG0840	transmembrane signaling receptor activity
CIG75_RS16525	COG2357	RelA SpoT domain protein
CIG75_RS16535	COG2309	aminopeptidase activity
CIG75_RS16540	COG1074	ATP-dependent DNA helicase activity
CIG75_RS16560	COG1595	DNA-templated transcription, initiation
CIG75_RS16565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CIG75_RS16570	COG1242	4 iron, 4 sulfur cluster binding
CIG75_RS16575	COG1233	COG1233 Phytoene dehydrogenase and related
CIG75_RS16580	COG1309	transcriptional regulator
CIG75_RS16595	COG2205	protein histidine kinase activity
CIG75_RS16600	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CIG75_RS16605	COG1122	ATPase activity
CIG75_RS16610	COG4721	ABC-type cobalt transport system, permease component
CIG75_RS16635	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CIG75_RS16640	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CIG75_RS16655	COG0656	L-ascorbic acid biosynthetic process
CIG75_RS16665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CIG75_RS16680	COG1132	(ABC) transporter
CIG75_RS16685	COG1132	(ABC) transporter
CIG75_RS16695	COG0109	protoheme IX farnesyltransferase activity
CIG75_RS16700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CIG75_RS16715	COG0116	Belongs to the methyltransferase superfamily
CIG75_RS16730	COG3186	Phenylalanine-4-hydroxylase
CIG75_RS16735	COG3253	May function as heme-dependent peroxidase
CIG75_RS16745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CIG75_RS16750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CIG75_RS16755	COG0436	Aminotransferase
CIG75_RS16760	COG1476	TRANSCRIPTIONal
CIG75_RS16765	COG3620	sequence-specific DNA binding
CIG75_RS16770	COG1607	acyl-coa hydrolase
CIG75_RS16790	COG2423	ornithine cyclodeaminase activity
CIG75_RS16795	COG4264	IucA IucC family
CIG75_RS16800	COG0019	diaminopimelate decarboxylase activity
CIG75_RS16830	COG1131	(ABC) transporter
CIG75_RS16835	COG1131	(ABC) transporter
CIG75_RS16845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CIG75_RS16850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_RS16855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CIG75_RS16880	COG1492	cobalamin metabolic process
CIG75_RS16885	COG0406	alpha-ribazole phosphatase activity
CIG75_RS16890	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CIG75_RS16955	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CIG75_RS16960	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CIG75_RS16965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CIG75_RS16970	COG2135	peptidase activity
CIG75_RS16980	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_RS16990	COG1278	Cold shock
CIG75_RS16995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CIG75_RS17040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CIG75_RS17045	COG0557	exoribonuclease II activity
CIG75_RS17055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CIG75_RS17060	COG0148	phosphopyruvate hydratase activity
CIG75_RS17070	COG0149	triose-phosphate isomerase activity
CIG75_RS17075	COG0126	phosphoglycerate kinase activity
CIG75_RS17090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CIG75_RS17100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CIG75_RS17105	COG0351	phosphomethylpyrimidine kinase
CIG75_RS17130	COG1368	sulfuric ester hydrolase activity
CIG75_RS17135	COG1573	uracil-dna glycosylase
CIG75_RS17160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CIG75_RS17165	COG1481	regulation of sporulation
CIG75_RS17170	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CIG75_RS17175	COG1660	Displays ATPase and GTPase activities
CIG75_RS17180	COG0840	transmembrane signaling receptor activity
CIG75_RS17190	COG0492	ferredoxin-NADP+ reductase activity
CIG75_RS17200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CIG75_RS17205	COG1592	Rubrerythrin
CIG75_RS17220	COG0386	Belongs to the glutathione peroxidase family
CIG75_RS17225	COG0697	spore germination
CIG75_RS17245	COG1131	(ABC) transporter
CIG75_RS17260	COG0456	acetyltransferase
CIG75_RS17280	COG2197	response regulator
CIG75_RS17300	COG2815	serine threonine protein kinase
CIG75_RS17300	COG0515	serine threonine protein kinase
CIG75_RS17310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CIG75_RS17315	COG1509	lysine 2,3-aminomutase activity
CIG75_RS17320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CIG75_RS17340	COG0110	maltose O-acetyltransferase activity
CIG75_RS17350	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CIG75_RS17355	COG0741	lytic transglycosylase activity
CIG75_RS17355	COG1196	nuclear chromosome segregation
CIG75_RS17355	COG0739	heme binding
CIG75_RS17365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CIG75_RS17380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CIG75_RS17385	COG0556	nucleotide-excision repair
CIG75_RS17390	COG1360	Flagellar Motor Protein
CIG75_RS17395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CIG75_RS17405	COG3409	Peptidoglycan-binding domain 1 protein
CIG75_RS17405	COG0793	Belongs to the peptidase S41A family
CIG75_RS17410	COG0741	lytic transglycosylase activity
CIG75_RS17410	COG1196	nuclear chromosome segregation
CIG75_RS17410	COG0739	heme binding
CIG75_RS17415	COG2177	Part of the ABC transporter FtsEX involved in
CIG75_RS17420	COG2884	Cell division ATP-binding protein ftsE
CIG75_RS17425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CIG75_RS17430	COG1121	(ABC) transporter
CIG75_RS17435	COG0803	Belongs to the bacterial solute-binding protein 9 family
CIG75_RS17505	COG2409	Drug exporters of the RND superfamily
CIG75_RS17530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CIG75_RS17560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CIG75_RS17565	COG2814	Major facilitator Superfamily
CIG75_RS17570	COG0577	efflux transmembrane transporter activity
CIG75_RS17575	COG1136	(ABC) transporter
CIG75_RS17575	COG0577	efflux transmembrane transporter activity
CIG75_RS17580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CIG75_RS17590	COG0165	Argininosuccinate lyase
CIG75_RS17595	COG0137	argininosuccinate synthase activity
CIG75_RS17600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CIG75_RS17605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CIG75_RS17660	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_RS17660	COG2247	cell wall binding repeat
CIG75_RS17665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CIG75_RS17670	COG0456	acetyltransferase
CIG75_RS17675	COG1214	PFAM Peptidase M22, glycoprotease
CIG75_RS17680	COG0802	atpase or kinase
CIG75_RS17685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CIG75_RS17690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CIG75_RS17700	COG2808	Putative FMN-binding domain
CIG75_RS17705	COG0588	phosphoglycerate mutase activity
CIG75_RS17720	COG2183	response to ionizing radiation
CIG75_RS17725	COG0671	phosphoesterase, PA-phosphatase related
CIG75_RS17730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CIG75_RS17740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CIG75_RS17775	COG1473	amidohydrolase
CIG75_RS17780	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CIG75_RS17785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CIG75_RS17795	COG3359	exonuclease
CIG75_RS17840	COG2801	Transposase and inactivated derivatives
CIG75_RS17865	COG1111	helicase
CIG75_RS17865	COG1205	dead DEAH box helicase
CIG75_RS17875	COG0735	belongs to the Fur family
CIG75_RS17885	COG2197	response regulator
CIG75_RS17890	COG4585	Histidine kinase
CIG75_RS17905	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CIG75_RS17910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CIG75_RS17925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CIG75_RS17935	COG2337	Toxic component of a toxin-antitoxin (TA) module
CIG75_RS17940	COG0864	Transcriptional regulator
CIG75_RS17945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CIG75_RS17950	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CIG75_RS17960	COG2050	protein possibly involved in aromatic compounds catabolism
CIG75_RS17975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CIG75_RS17980	COG1131	(ABC) transporter
CIG75_RS17995	COG1131	(ABC) transporter
CIG75_RS18015	COG2267	carboxylic ester hydrolase activity
CIG75_RS18025	COG0861	Integral membrane protein TerC family
CIG75_RS18050	COG0217	transcriptional regulatory protein
CIG75_RS18055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CIG75_RS18060	COG2814	Major facilitator Superfamily
CIG75_RS18100	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_RS18105	COG1250	3-hydroxyacyl-CoA dehydrogenase
CIG75_RS18120	COG1024	Enoyl-CoA hydratase
CIG75_RS18160	COG0477	Major facilitator Superfamily
CIG75_RS18285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIG75_RS18300	COG2801	Transposase and inactivated derivatives
CIG75_RS18365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIG75_RS18370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CIG75_RS18385	COG2323	membrane
CIG75_RS18395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CIG75_RS18460	COG0166	Belongs to the GPI family
CIG75_RS18480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CIG75_RS18490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CIG75_RS18495	COG0438	transferase activity, transferring glycosyl groups
CIG75_RS18510	COG0438	transferase activity, transferring glycosyl groups
CIG75_RS18540	COG1073	alpha beta
CIG75_RS18550	COG3850	Histidine kinase
CIG75_RS18550	COG5002	protein histidine kinase activity
CIG75_RS18555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CIG75_RS18560	COG0583	DNA-binding transcription factor activity
CIG75_RS18600	COG2814	Major facilitator Superfamily
CIG75_RS18610	COG0861	Integral membrane protein TerC family
CIG75_RS18620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CIG75_RS18645	COG0151	Belongs to the GarS family
CIG75_RS18650	COG0138	bifunctional purine biosynthesis protein purh
CIG75_RS18655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CIG75_RS18660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CIG75_RS18665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CIG75_RS18670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CIG75_RS18675	COG0047	phosphoribosylformylglycinamidine synthase activity
CIG75_RS18680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CIG75_RS18685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CIG75_RS18690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CIG75_RS18695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CIG75_RS18710	COG2252	PERMEase
CIG75_RS18715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CIG75_RS18715	COG0519	Catalyzes the synthesis of GMP from XMP
CIG75_RS18720	COG1305	Transglutaminase-like
CIG75_RS18730	COG0714	Associated with various cellular activities
CIG75_RS18745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CIG75_RS18755	COG0805	protein transport
CIG75_RS18760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CIG75_RS18770	COG0303	'Molybdopterin
CIG75_RS18795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CIG75_RS18800	COG0671	phosphoesterase, PA-phosphatase related
CIG75_RS18805	COG0488	(ABC) transporter
CIG75_RS18810	COG2814	Major facilitator Superfamily
CIG75_RS18815	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CIG75_RS18825	COG0028	Belongs to the TPP enzyme family
CIG75_RS18845	COG1612	heme a metabolic process
CIG75_RS18850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CIG75_RS18855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CIG75_RS18860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CIG75_RS18895	COG4824	toxin secretion phage lysis holin
CIG75_RS18920	COG3299	homolog of phage Mu protein gp47
CIG75_RS19205	COG0305	Participates in initiation and elongation during chromosome replication
CIG75_RS19280	COG1396	sequence-specific DNA binding
CIG75_RS19285	COG0582	viral genome integration into host DNA
CIG75_RS19295	COG2720	vancomycin resistance protein
CIG75_RS19495	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CIG75_RS19500	COG0653	protein targeting
CIG75_RS19540	COG0726	polysaccharide deacetylase
CIG75_RS19555	COG0489	protein tyrosine kinase activity
CIG75_RS19565	COG0860	N-Acetylmuramoyl-L-alanine amidase
CIG75_RS19570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CIG75_RS19575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CIG75_RS19580	COG0101	tRNA pseudouridine synthase activity
CIG75_RS19585	COG0203	ribosomal protein L17
CIG75_RS19590	COG0202	RNA polymerase activity
CIG75_RS19595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CIG75_RS19600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CIG75_RS19605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CIG75_RS19610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CIG75_RS19615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CIG75_RS19625	COG0024	Methionine aminopeptidase
CIG75_RS19630	COG0563	adenylate kinase activity
CIG75_RS19635	COG0201	protein transport
CIG75_RS19640	COG0200	Binds to the 23S rRNA
CIG75_RS19645	COG1841	ribosomal large subunit assembly
CIG75_RS19650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CIG75_RS19655	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CIG75_RS19660	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CIG75_RS19665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CIG75_RS19670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CIG75_RS19675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CIG75_RS19680	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CIG75_RS19685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CIG75_RS19690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CIG75_RS19695	COG0255	Belongs to the universal ribosomal protein uL29 family
CIG75_RS19700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CIG75_RS19705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CIG75_RS19715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CIG75_RS19720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CIG75_RS19725	COG0089	rRNA binding
CIG75_RS19730	COG0088	Forms part of the polypeptide exit tunnel
CIG75_RS19735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CIG75_RS19745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CIG75_RS19750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CIG75_RS19755	COG0049	tRNA binding
CIG75_RS19760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CIG75_RS19765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CIG75_RS19770	COG0085	RNA polymerase activity
CIG75_RS19775	COG2813	Specifically methylates the guanine in position
CIG75_RS19780	COG0222	ribosome binding
CIG75_RS19785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CIG75_RS19790	COG0081	regulation of translation
CIG75_RS19800	COG0250	Participates in transcription elongation, termination and antitermination
CIG75_RS19805	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CIG75_RS19810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CIG75_RS19820	COG3688	RNA-binding protein containing a PIN domain
CIG75_RS19825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CIG75_RS19830	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CIG75_RS19835	COG0215	cysteine-tRNA ligase activity
CIG75_RS19840	COG1045	serine acetyltransferase
CIG75_RS19845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CIG75_RS19850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CIG75_RS19855	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CIG75_RS19860	COG4956	integral membrane protein (PIN domain superfamily)
CIG75_RS19865	COG1183	phosphatidylcholine synthase activity
CIG75_RS19870	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CIG75_RS19875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CIG75_RS19880	COG0542	response to heat
CIG75_RS19885	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CIG75_RS19890	COG3880	PFAM UvrB UvrC protein
CIG75_RS19900	COG0546	phosphoglycolate phosphatase activity
CIG75_RS19905	COG1309	transcriptional regulator
CIG75_RS19945	COG1668	transmembrane transport
CIG75_RS19950	COG4555	ABC transporter
CIG75_RS19960	COG1131	(ABC) transporter
CIG75_RS20070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CIG75_RS20075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CIG75_RS20085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CIG75_RS20095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CIG75_RS20100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CIG75_RS20105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CIG75_RS20110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CIG75_RS20115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CIG75_RS20125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CIG75_RS20135	COG1595	DNA-templated transcription, initiation
CIG75_RS20145	COG1131	(ABC) transporter
CIG75_RS20155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CIG75_RS20160	COG0737	Belongs to the 5'-nucleotidase family
CIG75_RS20190	COG1396	sequence-specific DNA binding
CIG75_RS20195	COG0504	CTP synthase activity
CIG75_RS20200	COG3343	RNA polymerase activity
CIG75_RS20210	COG1098	S1 RNA binding domain
CIG75_RS20230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CIG75_RS20240	COG3956	TIGRFAM MazG family protein
CIG75_RS20245	COG2244	polysaccharide biosynthetic process
CIG75_RS20250	COG2002	toxin-antitoxin pair type II binding
CIG75_RS20270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CIG75_RS20280	COG0193	aminoacyl-tRNA hydrolase activity
CIG75_RS20285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CIG75_RS20295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CIG75_RS20300	COG2088	sporulation resulting in formation of a cellular spore
CIG75_RS20305	COG0251	oxidation-reduction process
CIG75_RS20310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CIG75_RS20320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CIG75_RS20325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CIG75_RS20325	COG0189	ligase activity
CIG75_RS20330	COG4242	Belongs to the peptidase S51 family
CIG75_RS20340	COG4466	Protein conserved in bacteria
CIG75_RS20355	COG2801	Transposase and inactivated derivatives
CIG75_RS20365	COG0617	tRNA 3'-terminal CCA addition
CIG75_RS20365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CIG75_RS20365	COG0517	IMP dehydrogenase activity
CIG75_RS20370	COG0697	spore germination
CIG75_RS20375	COG1136	(ABC) transporter
CIG75_RS20425	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CIG75_RS20430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CIG75_RS20435	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CIG75_RS20440	COG0772	Belongs to the SEDS family
CIG75_RS20445	COG0084	hydrolase, TatD family'
CIG75_RS20455	COG2002	toxin-antitoxin pair type II binding
CIG75_RS20460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CIG75_RS20465	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)