locus-tag	class	description
CBW65_RS00190	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CBW65_RS00195	COG1691	(AIR) carboxylase
CBW65_RS00200	COG1606	tRNA processing
CBW65_RS00235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CBW65_RS00240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CBW65_RS00250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CBW65_RS00255	COG1193	negative regulation of DNA recombination
CBW65_RS00270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CBW65_RS00275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CBW65_RS00275	COG0072	phenylalanine-tRNA ligase activity
CBW65_RS00280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CBW65_RS00290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBW65_RS00295	COG0569	domain protein
CBW65_RS00300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CBW65_RS00305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CBW65_RS00325	COG5002	protein histidine kinase activity
CBW65_RS00330	COG0745	RESPONSE REGULATOR receiver
CBW65_RS00350	COG0791	NLP P60 protein
CBW65_RS00390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CBW65_RS00435	COG1024	Enoyl-CoA hydratase
CBW65_RS00440	COG0436	Aminotransferase
CBW65_RS00445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CBW65_RS00460	COG1979	alcohol dehydrogenase
CBW65_RS00490	COG0306	phosphate transporter
CBW65_RS00510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CBW65_RS00530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CBW65_RS00535	COG1543	Belongs to the glycosyl hydrolase 57 family
CBW65_RS00550	COG0517	IMP dehydrogenase activity
CBW65_RS00555	COG0517	IMP dehydrogenase activity
CBW65_RS00570	COG3266	domain, Protein
CBW65_RS00570	COG2911	Protein conserved in bacteria
CBW65_RS00570	COG1361	Conserved repeat domain
CBW65_RS00575	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_RS00575	COG2247	cell wall binding repeat
CBW65_RS00590	COG0372	Belongs to the citrate synthase family
CBW65_RS00600	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CBW65_RS00625	COG0237	dephospho-CoA kinase activity
CBW65_RS00630	COG1971	Probably functions as a manganese efflux pump
CBW65_RS00635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CBW65_RS00640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBW65_RS00640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBW65_RS00645	COG4608	Belongs to the ABC transporter superfamily
CBW65_RS00650	COG0444	Belongs to the ABC transporter superfamily
CBW65_RS00655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBW65_RS00660	COG0601	transmembrane transport
CBW65_RS00665	COG0039	L-malate dehydrogenase activity
CBW65_RS00670	COG0538	isocitrate dehydrogenase activity
CBW65_RS00685	COG0824	Thioesterase
CBW65_RS00700	COG0825	malonyl-CoA metabolic process
CBW65_RS00705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CBW65_RS00715	COG0281	malic enzyme
CBW65_RS00720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CBW65_RS00725	COG0587	DNA-directed DNA polymerase activity
CBW65_RS00730	COG3153	acetyltransferase
CBW65_RS00730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBW65_RS00740	COG4109	DRTGG domain
CBW65_RS00755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBW65_RS00760	COG3679	Belongs to the UPF0342 family
CBW65_RS00775	COG0189	ligase activity
CBW65_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS00820	COG2719	SpoVR family
CBW65_RS00825	COG2718	Belongs to the UPF0229 family
CBW65_RS00830	COG2766	serine protein kinase
CBW65_RS00835	COG1309	transcriptional regulator
CBW65_RS00840	COG1511	domain protein
CBW65_RS00845	COG1131	(ABC) transporter
CBW65_RS00860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CBW65_RS00865	COG2199	diguanylate cyclase activity
CBW65_RS00865	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CBW65_RS00875	COG1414	Transcriptional regulator
CBW65_RS00880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CBW65_RS00885	COG0538	isocitrate dehydrogenase activity
CBW65_RS00895	COG1683	Conserved Protein
CBW65_RS00905	COG0328	RNA-DNA hybrid ribonuclease activity
CBW65_RS00910	COG1309	transcriptional regulator
CBW65_RS00920	COG0436	Aminotransferase
CBW65_RS00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_RS00960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CBW65_RS00965	COG0737	Belongs to the 5'-nucleotidase family
CBW65_RS00990	COG4493	Belongs to the UPF0637 family
CBW65_RS01035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CBW65_RS01040	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
CBW65_RS01045	COG1285	pathogenesis
CBW65_RS01075	COG0561	phosphatase activity
CBW65_RS01095	COG1122	ATPase activity
CBW65_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS01160	COG1408	metallophosphoesterase
CBW65_RS01165	COG1012	belongs to the aldehyde dehydrogenase family
CBW65_RS01175	COG0706	membrane insertase activity
CBW65_RS01210	COG1301	dicarboxylic acid transport
CBW65_RS01220	COG0438	transferase activity, transferring glycosyl groups
CBW65_RS01225	COG3944	biosynthesis protein
CBW65_RS01240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBW65_RS01245	COG2186	Transcriptional regulator
CBW65_RS01255	COG1509	lysine 2,3-aminomutase activity
CBW65_RS01260	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CBW65_RS01265	COG1126	abc transporter atp-binding protein
CBW65_RS01270	COG0765	amino acid transport
CBW65_RS01275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBW65_RS01280	COG0456	acetyltransferase
CBW65_RS01285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CBW65_RS01295	COG0670	Belongs to the BI1 family
CBW65_RS01320	COG1194	a g-specific adenine glycosylase
CBW65_RS01330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBW65_RS01335	COG2309	aminopeptidase activity
CBW65_RS01350	COG1846	Transcriptional regulator
CBW65_RS01370	COG1595	DNA-templated transcription, initiation
CBW65_RS01380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CBW65_RS01390	COG0288	reversible hydration of carbon dioxide
CBW65_RS01405	COG2226	methyltransferase
CBW65_RS01450	COG2207	Transcriptional regulator
CBW65_RS01450	COG3708	Transcriptional regulator
CBW65_RS01465	COG3708	Transcriptional regulator
CBW65_RS01465	COG2207	Transcriptional regulator
CBW65_RS01475	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CBW65_RS01500	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CBW65_RS01530	COG0492	ferredoxin-NADP+ reductase activity
CBW65_RS01540	COG0501	Belongs to the peptidase M48B family
CBW65_RS01545	COG0824	Thioesterase
CBW65_RS01575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CBW65_RS01605	COG1940	carbohydrate kinase activity
CBW65_RS01610	COG3842	ATPase activity
CBW65_RS01615	COG2508	Transcriptional regulator
CBW65_RS01620	COG0534	Mate efflux family protein
CBW65_RS01630	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CBW65_RS01640	COG0697	spore germination
CBW65_RS01655	COG0360	Binds together with S18 to 16S ribosomal RNA
CBW65_RS01660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CBW65_RS01680	COG3424	synthase
CBW65_RS01685	COG1755	Isoprenylcysteine carboxyl methyltransferase
CBW65_RS01690	COG3906	Belongs to the UPF0473 family
CBW65_RS01700	COG0861	Integral membrane protein TerC family
CBW65_RS01710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CBW65_RS01720	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CBW65_RS01735	COG3069	C4-dicarboxylate transmembrane transporter activity
CBW65_RS01745	COG1131	(ABC) transporter
CBW65_RS01750	COG1309	transcriptional regulator
CBW65_RS01755	COG1732	Glycine betaine
CBW65_RS01760	COG1174	glycine betaine transport
CBW65_RS01765	COG1125	glycine betaine transport
CBW65_RS01765	COG0517	IMP dehydrogenase activity
CBW65_RS01775	COG2333	competence protein COMEC
CBW65_RS01775	COG0658	competence protein
CBW65_RS01790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CBW65_RS01795	COG0488	(ABC) transporter
CBW65_RS01815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CBW65_RS01820	COG5522	Integral membrane protein (intg_mem_TP0381)
CBW65_RS01850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBW65_RS01860	COG0745	RESPONSE REGULATOR receiver
CBW65_RS01865	COG2205	protein histidine kinase activity
CBW65_RS01880	COG1733	regulation of RNA biosynthetic process
CBW65_RS01885	COG2259	Doxx family
CBW65_RS01890	COG1741	Belongs to the pirin family
CBW65_RS01905	COG0346	lactoylglutathione lyase activity
CBW65_RS01910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_RS01940	COG1484	DNA-dependent DNA replication
CBW65_RS01980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CBW65_RS01995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CBW65_RS02030	COG1484	DNA-dependent DNA replication
CBW65_RS02055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CBW65_RS02065	COG0514	ATP-dependent DNA helicase (RecQ)
CBW65_RS02095	COG1024	Enoyl-CoA hydratase
CBW65_RS02105	COG0577	efflux transmembrane transporter activity
CBW65_RS02110	COG1136	(ABC) transporter
CBW65_RS02110	COG0577	efflux transmembrane transporter activity
CBW65_RS02115	COG2205	protein histidine kinase activity
CBW65_RS02120	COG0745	RESPONSE REGULATOR receiver
CBW65_RS02125	COG1279	arginine transmembrane transporter activity
CBW65_RS02130	COG3437	response regulator, receiver
CBW65_RS02165	COG3852	Histidine kinase
CBW65_RS02170	COG0018	arginyl-trna synthetase
CBW65_RS02175	COG3339	Conserved Protein
CBW65_RS02250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CBW65_RS02255	COG4191	Histidine kinase
CBW65_RS02260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CBW65_RS02275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBW65_RS02280	COG0765	amino acid transport
CBW65_RS02285	COG0765	amino acid transport
CBW65_RS02290	COG4191	Histidine kinase
CBW65_RS02295	COG0784	Response regulator, receiver
CBW65_RS02340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CBW65_RS02360	COG0667	Aldo Keto reductase
CBW65_RS02365	COG0640	Transcriptional regulator
CBW65_RS02370	COG0477	Major facilitator Superfamily
CBW65_RS02380	COG2346	COG2346, Truncated hemoglobins
CBW65_RS02400	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CBW65_RS02405	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CBW65_RS02420	COG3214	Protein conserved in bacteria
CBW65_RS02430	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_RS02480	COG0346	lactoylglutathione lyase activity
CBW65_RS02485	COG0640	Transcriptional regulator
CBW65_RS02490	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CBW65_RS02495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CBW65_RS02530	COG3942	CHAP domain
CBW65_RS02530	COG1388	LysM domain
CBW65_RS02595	COG5444	nuclease activity
CBW65_RS02725	COG0646	methionine synthase
CBW65_RS02725	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CBW65_RS02730	COG1012	belongs to the aldehyde dehydrogenase family
CBW65_RS02745	COG0778	Nitroreductase
CBW65_RS02780	COG5002	protein histidine kinase activity
CBW65_RS02815	COG1801	Protein of unknown function DUF72
CBW65_RS02825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBW65_RS02850	COG5646	InterPro IPR014922
CBW65_RS02855	COG0288	reversible hydration of carbon dioxide
CBW65_RS02860	COG4326	sporulation control protein
CBW65_RS02870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CBW65_RS02880	COG1597	lipid kinase activity
CBW65_RS02885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CBW65_RS02890	COG0154	amidase activity
CBW65_RS02910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBW65_RS02920	COG0778	Nitroreductase
CBW65_RS02940	COG0783	Belongs to the Dps family
CBW65_RS02995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_RS03040	COG3813	Protein conserved in bacteria
CBW65_RS03055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CBW65_RS03055	COG2169	Transcriptional regulator
CBW65_RS03060	COG0346	lactoylglutathione lyase activity
CBW65_RS03080	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CBW65_RS03095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CBW65_RS03100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CBW65_RS03105	COG2070	2-Nitropropane dioxygenase
CBW65_RS03110	COG0393	Putative heavy-metal-binding
CBW65_RS03115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBW65_RS03120	COG4472	Bacterial protein of unknown function (DUF965)
CBW65_RS03130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_RS03135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CBW65_RS03140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBW65_RS03140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBW65_RS03145	COG0210	DNA helicase
CBW65_RS03155	COG0750	zinc metalloprotease
CBW65_RS03175	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CBW65_RS03180	COG4496	protein, YerC YecD
CBW65_RS03190	COG1201	RNA secondary structure unwinding
CBW65_RS03195	COG0402	S-adenosylhomocysteine deaminase activity
CBW65_RS03200	COG2226	methyltransferase
CBW65_RS03205	COG0528	UMP kinase activity
CBW65_RS03225	COG3973	AAA domain
CBW65_RS03245	COG2258	MOSC domain
CBW65_RS03255	COG2814	Major facilitator Superfamily
CBW65_RS03265	COG1929	Belongs to the glycerate kinase type-1 family
CBW65_RS03275	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS03290	COG0842	Transport permease protein
CBW65_RS03295	COG0842	Transport permease protein
CBW65_RS03295	COG1511	domain protein
CBW65_RS03300	COG1131	(ABC) transporter
CBW65_RS03305	COG2197	response regulator
CBW65_RS03310	COG4585	Histidine kinase
CBW65_RS03320	COG4085	toxin activity
CBW65_RS03320	COG1525	nuclease
CBW65_RS03320	COG0737	Belongs to the 5'-nucleotidase family
CBW65_RS03330	COG0778	Nitroreductase
CBW65_RS03335	COG3647	Membrane
CBW65_RS03340	COG2059	Chromate
CBW65_RS03345	COG0405	Gamma-glutamyltransferase
CBW65_RS03350	COG1131	(ABC) transporter
CBW65_RS03355	COG4473	ABC transporter
CBW65_RS03370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CBW65_RS03375	COG0165	Argininosuccinate lyase
CBW65_RS03380	COG0464	growth
CBW65_RS03385	COG0398	Pfam SNARE associated Golgi protein
CBW65_RS03405	COG1309	transcriptional regulator
CBW65_RS03415	COG4585	Histidine kinase
CBW65_RS03420	COG2197	response regulator
CBW65_RS03425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CBW65_RS03430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CBW65_RS03440	COG1132	(ABC) transporter
CBW65_RS03445	COG1132	(ABC) transporter
CBW65_RS03450	COG4533	DNA binding
CBW65_RS03480	COG0277	FAD linked oxidase domain protein
CBW65_RS03485	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CBW65_RS03490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CBW65_RS03515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_RS03525	COG1917	Cupin 2, conserved barrel domain protein
CBW65_RS03525	COG1396	sequence-specific DNA binding
CBW65_RS03535	COG0640	Transcriptional regulator
CBW65_RS03540	COG1309	transcriptional regulator
CBW65_RS03550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBW65_RS03555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CBW65_RS03560	COG4166	transmembrane transport
CBW65_RS03565	COG4991	sh3 domain protein
CBW65_RS03580	COG0577	efflux transmembrane transporter activity
CBW65_RS03585	COG1136	(ABC) transporter
CBW65_RS03610	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_RS03625	COG0300	oxidoreductase activity
CBW65_RS03625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CBW65_RS03625	COG3321	synthase
CBW65_RS03625	COG4221	oxidoreductase activity
CBW65_RS03650	COG0659	secondary active sulfate transmembrane transporter activity
CBW65_RS03655	COG0589	response to stress
CBW65_RS03660	COG2197	response regulator
CBW65_RS03665	COG4585	Histidine kinase
CBW65_RS03670	COG4758	membrane
CBW65_RS03675	COG1842	Phage shock protein A
CBW65_RS03710	COG1999	signal sequence binding
CBW65_RS03715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CBW65_RS03755	COG3973	AAA domain
CBW65_RS03760	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CBW65_RS03765	COG1876	peptidase activity
CBW65_RS03770	COG2814	Major facilitator Superfamily
CBW65_RS03780	COG3973	AAA domain
CBW65_RS03785	COG2124	cytochrome p450
CBW65_RS03790	COG2814	Major facilitator Superfamily
CBW65_RS03795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CBW65_RS03800	COG2076	Multidrug Resistance protein
CBW65_RS03805	COG2076	Multidrug Resistance protein
CBW65_RS03810	COG3384	dioxygenase
CBW65_RS03815	COG0477	Major facilitator Superfamily
CBW65_RS03850	COG1741	Belongs to the pirin family
CBW65_RS03860	COG0672	)-iron permease
CBW65_RS03865	COG2837	iron assimilation
CBW65_RS03870	COG2822	iron ion transport
CBW65_RS03895	COG0640	Transcriptional regulator
CBW65_RS04000	COG1937	Protein conserved in bacteria
CBW65_RS04005	COG2210	Belongs to the sulfur carrier protein TusA family
CBW65_RS04020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_RS04020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CBW65_RS04025	COG0730	response to heat
CBW65_RS04035	COG0425	Belongs to the sulfur carrier protein TusA family
CBW65_RS04045	COG2226	methyltransferase
CBW65_RS04060	COG5002	protein histidine kinase activity
CBW65_RS04060	COG3850	Histidine kinase
CBW65_RS04095	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CBW65_RS04100	COG0492	ferredoxin-NADP+ reductase activity
CBW65_RS04125	COG1358	cellular component organization or biogenesis
CBW65_RS04140	COG0861	Integral membrane protein TerC family
CBW65_RS04145	COG2310	stress, protein
CBW65_RS04150	COG2310	stress, protein
CBW65_RS04155	COG2310	stress, protein
CBW65_RS04160	COG2310	stress, protein
CBW65_RS04165	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CBW65_RS04170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CBW65_RS04220	COG1357	PFAM Pentapeptide repeats (8 copies)
CBW65_RS04230	COG0574	Belongs to the PEP-utilizing enzyme family
CBW65_RS04230	COG3848	Pyruvate phosphate dikinase
CBW65_RS04235	COG3848	Pyruvate phosphate dikinase
CBW65_RS04235	COG0574	Belongs to the PEP-utilizing enzyme family
CBW65_RS04240	COG2814	Major facilitator Superfamily
CBW65_RS04255	COG1595	DNA-templated transcription, initiation
CBW65_RS04265	COG0477	Major facilitator Superfamily
CBW65_RS04270	COG1064	alcohol dehydrogenase
CBW65_RS04275	COG2409	Drug exporters of the RND superfamily
CBW65_RS04285	COG3708	Transcriptional regulator
CBW65_RS04285	COG2207	Transcriptional regulator
CBW65_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS04340	COG0166	Belongs to the GPI family
CBW65_RS04345	COG1032	radical SAM domain protein
CBW65_RS04360	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS04370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CBW65_RS04375	COG2226	methyltransferase
CBW65_RS04395	COG0612	Peptidase, M16
CBW65_RS04400	COG1132	(ABC) transporter
CBW65_RS04405	COG1132	(ABC) transporter
CBW65_RS04445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBW65_RS04455	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CBW65_RS04465	COG5662	AntiSigma factor
CBW65_RS04470	COG1595	DNA-templated transcription, initiation
CBW65_RS04490	COG0730	response to heat
CBW65_RS04495	COG0175	sulfate reduction
CBW65_RS04500	COG0010	Belongs to the arginase family
CBW65_RS04505	COG4717	serine-type aminopeptidase activity
CBW65_RS04525	COG1083	cytidylyl-transferase
CBW65_RS04530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CBW65_RS04535	COG2089	acid synthase
CBW65_RS04540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CBW65_RS04545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CBW65_RS04565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CBW65_RS04570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBW65_RS04600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBW65_RS04605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBW65_RS04610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBW65_RS04615	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CBW65_RS04620	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CBW65_RS04630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CBW65_RS04635	COG4786	Flagellar basal body rod
CBW65_RS04635	COG1256	bacterial-type flagellum assembly
CBW65_RS04655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CBW65_RS04660	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS04665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CBW65_RS04670	COG1040	competence protein
CBW65_RS04675	COG1307	EDD domain protein, DegV family
CBW65_RS04690	COG5002	protein histidine kinase activity
CBW65_RS04695	COG0745	RESPONSE REGULATOR receiver
CBW65_RS04700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CBW65_RS04705	COG0704	Plays a role in the regulation of phosphate uptake
CBW65_RS04710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CBW65_RS04715	COG0581	inorganic phosphate transmembrane transporter activity
CBW65_RS04720	COG0573	inorganic phosphate transmembrane transporter activity
CBW65_RS04725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CBW65_RS04745	COG0697	spore germination
CBW65_RS04775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBW65_RS04785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CBW65_RS04795	COG1316	TRANSCRIPTIONal
CBW65_RS04810	COG1316	TRANSCRIPTIONal
CBW65_RS04855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CBW65_RS04885	COG3409	Peptidoglycan-binding domain 1 protein
CBW65_RS04885	COG0793	Belongs to the peptidase S41A family
CBW65_RS04890	COG3693	PFAM glycoside hydrolase, family 10
CBW65_RS05020	COG1739	Uncharacterized protein family UPF0029
CBW65_RS05035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CBW65_RS05040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBW65_RS05050	COG4786	Flagellar basal body rod
CBW65_RS05055	COG1077	Cell shape determining protein MreB Mrl
CBW65_RS05060	COG1609	Transcriptional regulator
CBW65_RS05065	COG0739	heme binding
CBW65_RS05070	COG2385	sporulation resulting in formation of a cellular spore
CBW65_RS05075	COG0739	heme binding
CBW65_RS05080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CBW65_RS05095	COG1007	ATP synthesis coupled electron transport
CBW65_RS05105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CBW65_RS05110	COG0713	ATP synthesis coupled electron transport
CBW65_RS05115	COG0839	Belongs to the complex I subunit 6 family
CBW65_RS05120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBW65_RS05125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CBW65_RS05135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBW65_RS05140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBW65_RS05145	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CBW65_RS05155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CBW65_RS05160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CBW65_RS05165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CBW65_RS05170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBW65_RS05175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CBW65_RS05180	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBW65_RS05205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CBW65_RS05210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CBW65_RS05215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CBW65_RS05225	COG0698	ribose 5-phosphate isomerase
CBW65_RS05230	COG1132	(ABC) transporter
CBW65_RS05235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CBW65_RS05245	COG1971	Probably functions as a manganese efflux pump
CBW65_RS05260	COG0009	L-threonylcarbamoyladenylate synthase
CBW65_RS05280	COG2890	protein-(glutamine-N5) methyltransferase activity
CBW65_RS05285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CBW65_RS05290	COG3872	metal-dependent enzyme
CBW65_RS05295	COG0697	spore germination
CBW65_RS05315	COG1435	thymidine kinase activity
CBW65_RS05320	COG0254	rRNA binding
CBW65_RS05340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CBW65_RS05345	COG1494	fructose-1,6-bisphosphatase
CBW65_RS05370	COG1473	amidohydrolase
CBW65_RS05375	COG2171	N-acyltransferase activity
CBW65_RS05390	COG3246	L-lysine catabolic process to acetate
CBW65_RS05395	COG1607	acyl-coa hydrolase
CBW65_RS05400	COG2204	response regulator
CBW65_RS05410	COG0242	peptide deformylase activity
CBW65_RS05415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CBW65_RS05425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CBW65_RS05430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CBW65_RS05435	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CBW65_RS05445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBW65_RS05450	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CBW65_RS05455	COG0037	tRNA processing
CBW65_RS05475	COG0515	serine threonine protein kinase
CBW65_RS05480	COG2304	oxidoreductase activity
CBW65_RS05485	COG2208	phosphoserine phosphatase activity
CBW65_RS05490	COG2131	deaminase
CBW65_RS05505	COG1960	acyl-CoA dehydrogenase activity
CBW65_RS05510	COG1960	acyl-CoA dehydrogenase activity
CBW65_RS05515	COG1024	Enoyl-CoA hydratase
CBW65_RS05520	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_RS05525	COG0183	Belongs to the thiolase family
CBW65_RS05530	COG2181	nitrate reductase activity
CBW65_RS05530	COG0247	lactate metabolic process
CBW65_RS05540	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CBW65_RS05570	COG0601	transmembrane transport
CBW65_RS05575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBW65_RS05590	COG1131	(ABC) transporter
CBW65_RS05615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_RS05620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CBW65_RS05625	COG1193	negative regulation of DNA recombination
CBW65_RS05635	COG1509	lysine 2,3-aminomutase activity
CBW65_RS05640	COG0604	alcohol dehydrogenase
CBW65_RS05645	COG3829	transcription factor binding
CBW65_RS05660	COG3227	Zinc metalloprotease (Elastase)
CBW65_RS05670	COG3227	Zinc metalloprotease (Elastase)
CBW65_RS05680	COG3227	Zinc metalloprotease (Elastase)
CBW65_RS05730	COG1937	Protein conserved in bacteria
CBW65_RS05735	COG0840	transmembrane signaling receptor activity
CBW65_RS05735	COG3290	protein histidine kinase activity
CBW65_RS05755	COG0010	Belongs to the arginase family
CBW65_RS05760	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CBW65_RS05765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CBW65_RS05770	COG0436	Aminotransferase
CBW65_RS05790	COG0840	transmembrane signaling receptor activity
CBW65_RS05815	COG0697	spore germination
CBW65_RS05830	COG2363	Small membrane protein
CBW65_RS05835	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CBW65_RS05850	COG1132	(ABC) transporter
CBW65_RS05855	COG1132	(ABC) transporter
CBW65_RS05860	COG0456	acetyltransferase
CBW65_RS05865	COG3153	acetyltransferase
CBW65_RS05865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBW65_RS05875	COG1733	regulation of RNA biosynthetic process
CBW65_RS05885	COG2814	Major facilitator Superfamily
CBW65_RS05900	COG1598	PFAM Uncharacterised protein family UPF0150
CBW65_RS05905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CBW65_RS05910	COG1984	allophanate hydrolase subunit 2
CBW65_RS05915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CBW65_RS05950	COG0515	serine threonine protein kinase
CBW65_RS05985	COG2814	Major facilitator Superfamily
CBW65_RS05990	COG1054	Belongs to the UPF0176 family
CBW65_RS05995	COG5002	protein histidine kinase activity
CBW65_RS06000	COG0154	amidase activity
CBW65_RS06005	COG0861	Integral membrane protein TerC family
CBW65_RS06020	COG0813	purine-nucleoside phosphorylase activity
CBW65_RS06030	COG0423	glycine-tRNA ligase activity
CBW65_RS06040	COG1113	amino acid transport
CBW65_RS06055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBW65_RS06065	COG0656	L-ascorbic acid biosynthetic process
CBW65_RS06140	COG0492	ferredoxin-NADP+ reductase activity
CBW65_RS06145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBW65_RS06160	COG1643	Atp-dependent helicase
CBW65_RS06165	COG1214	PFAM Peptidase M22, glycoprotease
CBW65_RS06165	COG0456	acetyltransferase
CBW65_RS06170	COG0488	(ABC) transporter
CBW65_RS06175	COG4895	conserved protein (DUF2196)
CBW65_RS06185	COG2814	Major facilitator Superfamily
CBW65_RS06190	COG1187	pseudouridine synthase activity
CBW65_RS06205	COG0167	dihydroorotate dehydrogenase activity
CBW65_RS06240	COG3290	protein histidine kinase activity
CBW65_RS06245	COG4565	transcriptional regulatory protein
CBW65_RS06295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CBW65_RS06295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CBW65_RS06315	COG0783	Belongs to the Dps family
CBW65_RS06320	COG0789	Transcriptional regulator
CBW65_RS06325	COG1902	pentaerythritol trinitrate reductase activity
CBW65_RS06330	COG3266	domain, Protein
CBW65_RS06330	COG2911	Protein conserved in bacteria
CBW65_RS06330	COG1361	Conserved repeat domain
CBW65_RS06360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_RS06370	COG3832	glyoxalase III activity
CBW65_RS06375	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CBW65_RS06380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CBW65_RS06390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CBW65_RS06415	COG4335	DNA alkylation repair
CBW65_RS06435	COG4191	Histidine kinase
CBW65_RS06445	COG2824	Alkylphosphonate utilization operon protein PhnA
CBW65_RS06450	COG3708	Transcriptional regulator
CBW65_RS06450	COG2207	Transcriptional regulator
CBW65_RS06465	COG0084	hydrolase, TatD family'
CBW65_RS06485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CBW65_RS06495	COG3655	Transcriptional regulator
CBW65_RS06505	COG0583	DNA-binding transcription factor activity
CBW65_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS06520	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CBW65_RS06540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CBW65_RS06560	COG0217	transcriptional regulatory protein
CBW65_RS06565	COG2264	protein methyltransferase activity
CBW65_RS06590	COG1484	DNA-dependent DNA replication
CBW65_RS06605	COG1136	(ABC) transporter
CBW65_RS06610	COG0577	efflux transmembrane transporter activity
CBW65_RS06620	COG3655	Transcriptional regulator
CBW65_RS06655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CBW65_RS06665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBW65_RS06675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CBW65_RS06685	COG4863	YycH protein
CBW65_RS06705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CBW65_RS06710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBW65_RS06720	COG0305	Participates in initiation and elongation during chromosome replication
CBW65_RS06725	COG0470	DNA polymerase III
CBW65_RS06725	COG1067	ATP-dependent peptidase activity
CBW65_RS06785	COG0644	oxidoreductase
CBW65_RS06800	COG1131	(ABC) transporter
CBW65_RS06805	COG1725	Transcriptional regulator
CBW65_RS06840	COG2814	Major facilitator Superfamily
CBW65_RS06845	COG1151	hydroxylamine reductase activity
CBW65_RS06855	COG0488	(ABC) transporter
CBW65_RS06865	COG1309	transcriptional regulator
CBW65_RS06870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CBW65_RS06880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CBW65_RS06885	COG1714	RDD family
CBW65_RS06895	COG1595	DNA-templated transcription, initiation
CBW65_RS06930	COG0251	oxidation-reduction process
CBW65_RS06935	COG2814	Major facilitator Superfamily
CBW65_RS06955	COG4941	Belongs to the sigma-70 factor family
CBW65_RS06985	COG4974	Belongs to the 'phage' integrase family
CBW65_RS06995	COG3436	PFAM IS66 Orf2 family protein
CBW65_RS07000	COG4372	Transposase
CBW65_RS07020	COG0629	single-stranded DNA binding
CBW65_RS07025	COG0360	Binds together with S18 to 16S ribosomal RNA
CBW65_RS07030	COG0012	GTP binding
CBW65_RS07055	COG0243	molybdopterin cofactor binding
CBW65_RS07060	COG4481	Protein conserved in bacteria
CBW65_RS07065	COG0668	transmembrane transport
CBW65_RS07105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CBW65_RS07110	COG1475	DNA binding
CBW65_RS07115	COG1192	Involved in chromosome partitioning
CBW65_RS07120	COG1475	DNA binding
CBW65_RS07125	COG0357	Ribosomal RNA small subunit methyltransferase G
CBW65_RS07130	COG0445	tRNA wobble uridine modification
CBW65_RS07135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CBW65_RS07140	COG1847	R3H domain protein
CBW65_RS07150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CBW65_RS07155	COG0594	ribonuclease P activity
CBW65_RS07160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CBW65_RS07175	COG0592	DNA-directed DNA polymerase activity
CBW65_RS07180	COG2501	S4 domain
CBW65_RS07185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBW65_RS07195	COG0187	DNA topoisomerase II activity
CBW65_RS07200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CBW65_RS07210	COG3220	belongs to the UPF0276 family
CBW65_RS07255	COG0516	GMP reductase activity
CBW65_RS07255	COG0517	IMP dehydrogenase activity
CBW65_RS07260	COG1686	Belongs to the peptidase S11 family
CBW65_RS07270	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CBW65_RS07285	COG1428	Deoxynucleoside kinase
CBW65_RS07290	COG1428	Deoxynucleoside kinase
CBW65_RS07310	COG0590	tRNA wobble adenosine to inosine editing
CBW65_RS07325	COG3852	Histidine kinase
CBW65_RS07330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CBW65_RS07335	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CBW65_RS07340	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CBW65_RS07435	COG4372	Transposase
CBW65_RS07440	COG3436	PFAM IS66 Orf2 family protein
CBW65_RS07505	COG1982	Orn Lys Arg decarboxylase major
CBW65_RS07510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CBW65_RS07515	COG3870	Protein conserved in bacteria
CBW65_RS07520	COG1728	Protein conserved in bacteria
CBW65_RS07525	COG0470	DNA polymerase III
CBW65_RS07530	COG1774	PSP1 C-terminal conserved region
CBW65_RS07535	COG4467	Involved in initiation control of chromosome replication
CBW65_RS07575	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CBW65_RS07580	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CBW65_RS07585	COG2002	toxin-antitoxin pair type II binding
CBW65_RS07595	COG0084	hydrolase, TatD family'
CBW65_RS07605	COG0772	Belongs to the SEDS family
CBW65_RS07610	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CBW65_RS07615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CBW65_RS07620	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CBW65_RS07645	COG0697	spore germination
CBW65_RS07665	COG4466	Protein conserved in bacteria
CBW65_RS07675	COG4242	Belongs to the peptidase S51 family
CBW65_RS07680	COG0189	ligase activity
CBW65_RS07680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CBW65_RS07685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CBW65_RS07695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CBW65_RS07700	COG0251	oxidation-reduction process
CBW65_RS07705	COG2088	sporulation resulting in formation of a cellular spore
CBW65_RS07710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CBW65_RS07730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CBW65_RS07735	COG0193	aminoacyl-tRNA hydrolase activity
CBW65_RS07745	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CBW65_RS07755	COG2002	toxin-antitoxin pair type II binding
CBW65_RS07760	COG2244	polysaccharide biosynthetic process
CBW65_RS07765	COG3956	TIGRFAM MazG family protein
CBW65_RS07775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CBW65_RS07795	COG1098	S1 RNA binding domain
CBW65_RS07805	COG3343	RNA polymerase activity
CBW65_RS07810	COG0504	CTP synthase activity
CBW65_RS07850	COG3764	Sortase (surface protein transpeptidase)
CBW65_RS07855	COG0737	Belongs to the 5'-nucleotidase family
CBW65_RS07860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CBW65_RS07870	COG1131	(ABC) transporter
CBW65_RS07885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CBW65_RS07895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CBW65_RS07900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CBW65_RS07905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CBW65_RS07910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CBW65_RS07915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CBW65_RS07925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CBW65_RS07935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CBW65_RS08080	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CBW65_RS08090	COG4555	ABC transporter
CBW65_RS08095	COG1668	transmembrane transport
CBW65_RS08160	COG1309	transcriptional regulator
CBW65_RS08165	COG0546	phosphoglycolate phosphatase activity
CBW65_RS08175	COG3880	PFAM UvrB UvrC protein
CBW65_RS08180	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CBW65_RS08185	COG0542	response to heat
CBW65_RS08190	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CBW65_RS08195	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CBW65_RS08200	COG1183	phosphatidylcholine synthase activity
CBW65_RS08205	COG4956	integral membrane protein (PIN domain superfamily)
CBW65_RS08210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CBW65_RS08215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CBW65_RS08220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CBW65_RS08225	COG1045	serine acetyltransferase
CBW65_RS08230	COG0215	cysteine-tRNA ligase activity
CBW65_RS08235	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CBW65_RS08240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBW65_RS08245	COG3688	RNA-binding protein containing a PIN domain
CBW65_RS08255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CBW65_RS08260	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CBW65_RS08265	COG0250	Participates in transcription elongation, termination and antitermination
CBW65_RS08275	COG0081	regulation of translation
CBW65_RS08285	COG0222	ribosome binding
CBW65_RS08290	COG2813	Specifically methylates the guanine in position
CBW65_RS08295	COG0085	RNA polymerase activity
CBW65_RS08300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CBW65_RS08305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CBW65_RS08310	COG0049	tRNA binding
CBW65_RS08315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CBW65_RS08330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CBW65_RS08335	COG0088	Forms part of the polypeptide exit tunnel
CBW65_RS08340	COG0089	rRNA binding
CBW65_RS08345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CBW65_RS08350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CBW65_RS08360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CBW65_RS08365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CBW65_RS08370	COG0255	Belongs to the universal ribosomal protein uL29 family
CBW65_RS08375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CBW65_RS08380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CBW65_RS08385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CBW65_RS08390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CBW65_RS08395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CBW65_RS08400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CBW65_RS08405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CBW65_RS08410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CBW65_RS08415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CBW65_RS08420	COG1841	ribosomal large subunit assembly
CBW65_RS08425	COG0200	Binds to the 23S rRNA
CBW65_RS08430	COG0201	protein transport
CBW65_RS08435	COG0563	adenylate kinase activity
CBW65_RS08440	COG0024	Methionine aminopeptidase
CBW65_RS08450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CBW65_RS08455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CBW65_RS08460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CBW65_RS08465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CBW65_RS08470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CBW65_RS08475	COG0202	RNA polymerase activity
CBW65_RS08480	COG0203	ribosomal protein L17
CBW65_RS08485	COG0101	tRNA pseudouridine synthase activity
CBW65_RS08490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CBW65_RS08495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CBW65_RS08500	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_RS08510	COG0489	protein tyrosine kinase activity
CBW65_RS08525	COG0726	polysaccharide deacetylase
CBW65_RS08550	COG0765	amino acid transport
CBW65_RS08580	COG0653	protein targeting
CBW65_RS08585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CBW65_RS08815	COG2720	vancomycin resistance protein
CBW65_RS08830	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CBW65_RS08835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CBW65_RS08840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CBW65_RS08845	COG1612	heme a metabolic process
CBW65_RS08865	COG0028	Belongs to the TPP enzyme family
CBW65_RS08880	COG2814	Major facilitator Superfamily
CBW65_RS08885	COG0488	(ABC) transporter
CBW65_RS08890	COG0671	phosphoesterase, PA-phosphatase related
CBW65_RS08955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CBW65_RS08960	COG3693	PFAM glycoside hydrolase, family 10
CBW65_RS08970	COG0746	molybdenum cofactor guanylyltransferase activity
CBW65_RS08985	COG0303	'Molybdopterin
CBW65_RS08990	COG1763	Mo-molybdopterin cofactor biosynthetic process
CBW65_RS08995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CBW65_RS09000	COG0805	protein transport
CBW65_RS09010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CBW65_RS09015	COG0459	protein refolding
CBW65_RS09020	COG4942	peptidase
CBW65_RS09025	COG0714	Associated with various cellular activities
CBW65_RS09035	COG1305	Transglutaminase-like
CBW65_RS09040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CBW65_RS09040	COG0519	Catalyzes the synthesis of GMP from XMP
CBW65_RS09045	COG2252	PERMEase
CBW65_RS09060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CBW65_RS09065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CBW65_RS09070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CBW65_RS09075	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CBW65_RS09080	COG0047	phosphoribosylformylglycinamidine synthase activity
CBW65_RS09085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CBW65_RS09090	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CBW65_RS09095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CBW65_RS09100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CBW65_RS09110	COG0151	Belongs to the GarS family
CBW65_RS09130	COG0861	Integral membrane protein TerC family
CBW65_RS09140	COG2319	Wd-40 repeat
CBW65_RS09145	COG2814	Major facilitator Superfamily
CBW65_RS09155	COG1408	metallophosphoesterase
CBW65_RS09170	COG0583	DNA-binding transcription factor activity
CBW65_RS09185	COG0681	Belongs to the peptidase S26 family
CBW65_RS09190	COG0681	Belongs to the peptidase S26 family
CBW65_RS09195	COG1595	DNA-templated transcription, initiation
CBW65_RS09200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CBW65_RS09205	COG5002	protein histidine kinase activity
CBW65_RS09205	COG3850	Histidine kinase
CBW65_RS09210	COG0745	RESPONSE REGULATOR receiver
CBW65_RS09220	COG1073	alpha beta
CBW65_RS09235	COG1595	DNA-templated transcription, initiation
CBW65_RS09260	COG0438	transferase activity, transferring glycosyl groups
CBW65_RS09275	COG0438	transferase activity, transferring glycosyl groups
CBW65_RS09280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CBW65_RS09290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CBW65_RS09295	COG1086	Polysaccharide biosynthesis protein
CBW65_RS09310	COG0166	Belongs to the GPI family
CBW65_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS09400	COG1192	Involved in chromosome partitioning
CBW65_RS09470	COG0180	Tryptophanyl-tRNA synthetase
CBW65_RS09580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBW65_RS09585	COG2078	PFAM AMMECR1 domain protein
CBW65_RS09585	COG3885	ferrous iron binding
CBW65_RS09645	COG0477	Major facilitator Superfamily
CBW65_RS09685	COG1024	Enoyl-CoA hydratase
CBW65_RS09700	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_RS09705	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_RS09710	COG0183	Belongs to the thiolase family
CBW65_RS09715	COG1012	belongs to the aldehyde dehydrogenase family
CBW65_RS09755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CBW65_RS09785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CBW65_RS09790	COG1971	Probably functions as a manganese efflux pump
CBW65_RS09795	COG0861	Integral membrane protein TerC family
CBW65_RS09800	COG2267	carboxylic ester hydrolase activity
CBW65_RS09805	COG0316	Belongs to the HesB IscA family
CBW65_RS09815	COG1131	(ABC) transporter
CBW65_RS09830	COG1131	(ABC) transporter
CBW65_RS09835	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CBW65_RS09860	COG2050	protein possibly involved in aromatic compounds catabolism
CBW65_RS09865	COG0736	holo-[acyl-carrier-protein] synthase activity
CBW65_RS09870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CBW65_RS09875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CBW65_RS09880	COG0864	Transcriptional regulator
CBW65_RS09885	COG2337	Toxic component of a toxin-antitoxin (TA) module
CBW65_RS09895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CBW65_RS09900	COG2205	protein histidine kinase activity
CBW65_RS09910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CBW65_RS09915	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CBW65_RS09995	COG2814	Major facilitator Superfamily
CBW65_RS10060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CBW65_RS10075	COG4585	Histidine kinase
CBW65_RS10080	COG2197	response regulator
CBW65_RS10115	COG5002	protein histidine kinase activity
CBW65_RS10120	COG1205	dead DEAH box helicase
CBW65_RS10120	COG1111	helicase
CBW65_RS10135	COG1846	Transcriptional regulator
CBW65_RS10140	COG2814	Major facilitator Superfamily
CBW65_RS10145	COG0471	metal ion transport
CBW65_RS10145	COG3273	potassium ion transport
CBW65_RS10175	COG3359	exonuclease
CBW65_RS10180	COG3706	GGDEF domain
CBW65_RS10185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CBW65_RS10190	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CBW65_RS10195	COG1473	amidohydrolase
CBW65_RS10240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CBW65_RS10245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CBW65_RS10250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CBW65_RS10255	COG0671	phosphoesterase, PA-phosphatase related
CBW65_RS10270	COG2183	response to ionizing radiation
CBW65_RS10295	COG2720	vancomycin resistance protein
CBW65_RS10320	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CBW65_RS10340	COG2808	Putative FMN-binding domain
CBW65_RS10350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CBW65_RS10355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CBW65_RS10360	COG0802	atpase or kinase
CBW65_RS10365	COG1214	PFAM Peptidase M22, glycoprotease
CBW65_RS10370	COG0456	acetyltransferase
CBW65_RS10375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CBW65_RS10385	COG1247	-acetyltransferase
CBW65_RS10390	COG0640	Transcriptional regulator
CBW65_RS10395	COG0346	lactoylglutathione lyase activity
CBW65_RS10405	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_RS10430	COG5001	Diguanylate cyclase
CBW65_RS10430	COG3300	MHYT domain
CBW65_RS10480	COG2814	Major facilitator Superfamily
CBW65_RS10500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBW65_RS10505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CBW65_RS10510	COG0137	argininosuccinate synthase activity
CBW65_RS10515	COG0165	Argininosuccinate lyase
CBW65_RS10530	COG1136	(ABC) transporter
CBW65_RS10535	COG0577	efflux transmembrane transporter activity
CBW65_RS10545	COG0803	Belongs to the bacterial solute-binding protein 9 family
CBW65_RS10550	COG1121	(ABC) transporter
CBW65_RS10555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CBW65_RS10560	COG2884	Cell division ATP-binding protein ftsE
CBW65_RS10565	COG2177	Part of the ABC transporter FtsEX involved in
CBW65_RS10570	COG0739	heme binding
CBW65_RS10570	COG0741	lytic transglycosylase activity
CBW65_RS10570	COG1196	nuclear chromosome segregation
CBW65_RS10575	COG3409	Peptidoglycan-binding domain 1 protein
CBW65_RS10575	COG0793	Belongs to the peptidase S41A family
CBW65_RS10585	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CBW65_RS10590	COG1360	Flagellar Motor Protein
CBW65_RS10595	COG0556	nucleotide-excision repair
CBW65_RS10605	COG1106	Psort location Cytoplasmic, score
CBW65_RS10620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CBW65_RS10635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CBW65_RS10645	COG0741	lytic transglycosylase activity
CBW65_RS10645	COG1196	nuclear chromosome segregation
CBW65_RS10645	COG0739	heme binding
CBW65_RS10650	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBW65_RS10655	COG0546	phosphoglycolate phosphatase activity
CBW65_RS10660	COG0110	maltose O-acetyltransferase activity
CBW65_RS10665	COG0439	Biotin carboxylase
CBW65_RS10675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBW65_RS10680	COG1509	lysine 2,3-aminomutase activity
CBW65_RS10685	COG0124	histidyl-tRNA synthetase
CBW65_RS10690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CBW65_RS10695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CBW65_RS10700	COG0131	Imidazoleglycerol-phosphate dehydratase
CBW65_RS10705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CBW65_RS10710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CBW65_RS10720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CBW65_RS10720	COG0140	phosphoribosyl-ATP diphosphatase activity
CBW65_RS10730	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_RS10755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CBW65_RS10790	COG0697	spore germination
CBW65_RS10800	COG0386	Belongs to the glutathione peroxidase family
CBW65_RS10805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CBW65_RS10810	COG0601	transmembrane transport
CBW65_RS10815	COG4166	transmembrane transport
CBW65_RS10830	COG1592	Rubrerythrin
CBW65_RS10835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CBW65_RS10840	COG0457	Tetratricopeptide repeat
CBW65_RS10845	COG0492	ferredoxin-NADP+ reductase activity
CBW65_RS10855	COG1051	belongs to the nudix hydrolase family
CBW65_RS10860	COG0840	transmembrane signaling receptor activity
CBW65_RS10865	COG1660	Displays ATPase and GTPase activities
CBW65_RS10870	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CBW65_RS10875	COG1481	regulation of sporulation
CBW65_RS10880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CBW65_RS10905	COG1573	uracil-dna glycosylase
CBW65_RS10910	COG1368	sulfuric ester hydrolase activity
CBW65_RS10930	COG1368	sulfuric ester hydrolase activity
CBW65_RS10935	COG3300	MHYT domain
CBW65_RS10935	COG5001	Diguanylate cyclase
CBW65_RS10965	COG0351	phosphomethylpyrimidine kinase
CBW65_RS10970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CBW65_RS10975	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CBW65_RS10980	COG2390	Transcriptional regulator
CBW65_RS10990	COG0126	phosphoglycerate kinase activity
CBW65_RS10995	COG0149	triose-phosphate isomerase activity
CBW65_RS11000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CBW65_RS11005	COG0148	phosphopyruvate hydratase activity
CBW65_RS11010	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CBW65_RS11020	COG0557	exoribonuclease II activity
CBW65_RS11040	COG1090	epimerase
CBW65_RS11045	COG1842	Phage shock protein A
CBW65_RS11060	COG1278	Cold shock
CBW65_RS11070	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_RS11080	COG2135	peptidase activity
CBW65_RS11090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CBW65_RS11095	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CBW65_RS11100	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CBW65_RS11155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CBW65_RS11165	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CBW65_RS11170	COG0406	alpha-ribazole phosphatase activity
CBW65_RS11175	COG1492	cobalamin metabolic process
CBW65_RS11200	COG3885	ferrous iron binding
CBW65_RS11200	COG2078	PFAM AMMECR1 domain protein
CBW65_RS11210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CBW65_RS11215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CBW65_RS11220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CBW65_RS11265	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CBW65_RS11280	COG1074	ATP-dependent DNA helicase activity
CBW65_RS11320	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBW65_RS11365	COG4372	Transposase
CBW65_RS11385	COG0019	diaminopimelate decarboxylase activity
CBW65_RS11400	COG4264	IucA IucC family
CBW65_RS11410	COG2423	ornithine cyclodeaminase activity
CBW65_RS11425	COG4264	IucA IucC family
CBW65_RS11430	COG2814	Major facilitator Superfamily
CBW65_RS11435	COG4264	IucA IucC family
CBW65_RS11440	COG0019	diaminopimelate decarboxylase activity
CBW65_RS11450	COG1309	transcriptional regulator
CBW65_RS11485	COG3620	sequence-specific DNA binding
CBW65_RS11490	COG1476	TRANSCRIPTIONal
CBW65_RS11495	COG0436	Aminotransferase
CBW65_RS11505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBW65_RS11510	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CBW65_RS11530	COG2080	2 iron, 2 sulfur cluster binding
CBW65_RS11530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CBW65_RS11545	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CBW65_RS11550	COG0746	molybdenum cofactor guanylyltransferase activity
CBW65_RS11555	COG3253	May function as heme-dependent peroxidase
CBW65_RS11560	COG3186	Phenylalanine-4-hydroxylase
CBW65_RS11575	COG0116	Belongs to the methyltransferase superfamily
CBW65_RS11585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CBW65_RS11590	COG0109	protoheme IX farnesyltransferase activity
CBW65_RS11600	COG1132	(ABC) transporter
CBW65_RS11605	COG1132	(ABC) transporter
CBW65_RS11625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CBW65_RS11645	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBW65_RS11650	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBW65_RS11680	COG4721	ABC-type cobalt transport system, permease component
CBW65_RS11685	COG1122	ATPase activity
CBW65_RS11690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CBW65_RS11695	COG2205	protein histidine kinase activity
CBW65_RS11700	COG2205	protein histidine kinase activity
CBW65_RS11715	COG1309	transcriptional regulator
CBW65_RS11725	COG1242	4 iron, 4 sulfur cluster binding
CBW65_RS11730	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CBW65_RS11735	COG1595	DNA-templated transcription, initiation
CBW65_RS11755	COG1074	ATP-dependent DNA helicase activity
CBW65_RS11770	COG2357	RelA SpoT domain protein
CBW65_RS11785	COG0396	ATPase activity
CBW65_RS11790	COG0719	Fe-S assembly protein
CBW65_RS11795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CBW65_RS11800	COG0822	iron-sulfur transferase activity
CBW65_RS11805	COG0719	Fe-S assembly protein
CBW65_RS11810	COG0840	transmembrane signaling receptor activity
CBW65_RS11815	COG0840	transmembrane signaling receptor activity
CBW65_RS11820	COG0475	glutathione-regulated potassium exporter activity
CBW65_RS11835	COG1309	transcriptional regulator
CBW65_RS11840	COG2086	electron transfer activity
CBW65_RS11845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CBW65_RS11885	COG0124	histidyl-tRNA synthetase
CBW65_RS11905	COG2264	protein methyltransferase activity
CBW65_RS11920	COG2814	Major facilitator Superfamily
CBW65_RS11930	COG3402	PFAM membrane-flanked domain
CBW65_RS11935	COG3428	Bacterial PH domain
CBW65_RS11940	COG0372	Belongs to the citrate synthase family
CBW65_RS11945	COG0583	DNA-binding transcription factor activity
CBW65_RS11955	COG0564	pseudouridine synthase activity
CBW65_RS11965	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CBW65_RS11970	COG0179	Fumarylacetoacetate (FAA) hydrolase
CBW65_RS11975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CBW65_RS11980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CBW65_RS12045	COG0537	adenosine 5'-monophosphoramidase activity
CBW65_RS12085	COG4372	Transposase
CBW65_RS12090	COG3436	PFAM IS66 Orf2 family protein
CBW65_RS12135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CBW65_RS12150	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CBW65_RS12160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CBW65_RS12175	COG3436	PFAM IS66 Orf2 family protein
CBW65_RS12180	COG4372	Transposase
CBW65_RS12205	COG1363	Peptidase, m42
CBW65_RS12255	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CBW65_RS12260	COG4166	transmembrane transport
CBW65_RS12265	COG3266	domain, Protein
CBW65_RS12265	COG1361	Conserved repeat domain
CBW65_RS12265	COG2911	Protein conserved in bacteria
CBW65_RS12275	COG5002	protein histidine kinase activity
CBW65_RS12285	COG3842	ATPase activity
CBW65_RS12290	COG1098	S1 RNA binding domain
CBW65_RS12310	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CBW65_RS12335	COG3584	3D domain protein
CBW65_RS12335	COG3583	domain protein
CBW65_RS12340	COG1024	Enoyl-CoA hydratase
CBW65_RS12340	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_RS12345	COG0183	Belongs to the thiolase family
CBW65_RS12350	COG1960	acyl-CoA dehydrogenase activity
CBW65_RS12355	COG1122	ATPase activity
CBW65_RS12360	COG1122	ATPase activity
CBW65_RS12365	COG1268	BioY protein
CBW65_RS12375	COG0671	phosphoesterase, PA-phosphatase related
CBW65_RS12380	COG1575	Belongs to the MenA family. Type 1 subfamily
CBW65_RS12390	COG1070	Carbohydrate kinase
CBW65_RS12400	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CBW65_RS12425	COG3875	lactate racemase activity
CBW65_RS12430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_RS12430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_RS12430	COG1703	isobutyryl-CoA mutase activity
CBW65_RS12455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBW65_RS12460	COG2222	sugar isomerase
CBW65_RS12465	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_RS12470	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_RS12475	COG2172	sigma factor antagonist activity
CBW65_RS12485	COG0531	amino acid
CBW65_RS12505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CBW65_RS12510	COG0583	DNA-binding transcription factor activity
CBW65_RS12515	COG2340	Cysteine-rich secretory protein family
CBW65_RS12525	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CBW65_RS12530	COG1252	NADH dehydrogenase
CBW65_RS12550	COG0612	Peptidase, M16
CBW65_RS12555	COG0612	Peptidase, M16
CBW65_RS12565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBW65_RS12570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBW65_RS12625	COG1337	RAMP superfamily
CBW65_RS12655	COG3209	COG3209 Rhs family protein
CBW65_RS12665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CBW65_RS12670	COG0602	queuosine metabolic process
CBW65_RS12675	COG0720	synthase
CBW65_RS12680	COG4974	Belongs to the 'phage' integrase family
CBW65_RS12690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CBW65_RS12700	COG1956	GAF domain-containing protein
CBW65_RS12715	COG1213	nucleotidyl transferase
CBW65_RS12725	COG0426	domain, Protein
CBW65_RS12730	COG0772	Belongs to the SEDS family
CBW65_RS12735	COG5002	protein histidine kinase activity
CBW65_RS12760	COG0584	glycerophosphoryl diester phosphodiesterase
CBW65_RS12765	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CBW65_RS12775	COG1595	DNA-templated transcription, initiation
CBW65_RS12785	COG2814	Major facilitator Superfamily
CBW65_RS12790	COG0785	Cytochrome C biogenesis protein
CBW65_RS12795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_RS12805	COG0745	RESPONSE REGULATOR receiver
CBW65_RS12810	COG5002	protein histidine kinase activity
CBW65_RS12815	COG2132	Multicopper oxidase
CBW65_RS12825	COG0640	Transcriptional regulator
CBW65_RS12845	COG0436	Aminotransferase
CBW65_RS12850	COG1850	ribulose-bisphosphate carboxylase activity
CBW65_RS12855	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CBW65_RS12860	COG0235	Class ii aldolase
CBW65_RS12865	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CBW65_RS12935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CBW65_RS12955	COG0583	DNA-binding transcription factor activity
CBW65_RS12970	COG3340	Belongs to the peptidase S51 family
CBW65_RS12975	COG0346	lactoylglutathione lyase activity
CBW65_RS12985	COG1607	acyl-coa hydrolase
CBW65_RS12990	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CBW65_RS13015	COG5002	protein histidine kinase activity
CBW65_RS13020	COG0561	phosphatase activity
CBW65_RS13030	COG3290	protein histidine kinase activity
CBW65_RS13030	COG3829	transcription factor binding
CBW65_RS13070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CBW65_RS13075	COG1294	oxidase, subunit
CBW65_RS13080	COG1271	oxidase subunit
CBW65_RS13095	COG3546	catalase activity
CBW65_RS13110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CBW65_RS13120	COG0791	NLP P60 protein
CBW65_RS13125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CBW65_RS13160	COG2270	Major facilitator Superfamily
CBW65_RS13170	COG1164	Oligoendopeptidase f
CBW65_RS13175	COG3852	Histidine kinase
CBW65_RS13185	COG1022	Amp-dependent synthetase and ligase
CBW65_RS13205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_RS13215	COG0006	proline dipeptidase activity
CBW65_RS13220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CBW65_RS13225	COG2357	RelA SpoT domain protein
CBW65_RS13235	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CBW65_RS13240	COG1832	CoA-binding protein
CBW65_RS13245	COG1393	Belongs to the ArsC family
CBW65_RS13250	COG0612	Peptidase, M16
CBW65_RS13255	COG0697	spore germination
CBW65_RS13260	COG1368	sulfuric ester hydrolase activity
CBW65_RS13275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CBW65_RS13280	COG0765	amino acid transport
CBW65_RS13285	COG1126	abc transporter atp-binding protein
CBW65_RS13315	COG2814	Major facilitator Superfamily
CBW65_RS13330	COG1982	Orn Lys Arg decarboxylase major
CBW65_RS13335	COG3584	3D domain protein
CBW65_RS13335	COG1388	LysM domain
CBW65_RS13340	COG0297	glycogen (starch) synthase activity
CBW65_RS13350	COG0674	pyruvate-flavodoxin oxidoreductase activity
CBW65_RS13350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CBW65_RS13355	COG1013	pyruvate-flavodoxin oxidoreductase activity
CBW65_RS13375	COG0583	DNA-binding transcription factor activity
CBW65_RS13380	COG2211	Major facilitator Superfamily
CBW65_RS13390	COG0628	permease
CBW65_RS13395	COG0628	permease
CBW65_RS13400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CBW65_RS13410	COG1078	dGTPase activity
CBW65_RS13415	COG0561	phosphatase activity
CBW65_RS13420	COG0840	transmembrane signaling receptor activity
CBW65_RS13435	COG3639	organic phosphonate transmembrane transporter activity
CBW65_RS13440	COG3639	organic phosphonate transmembrane transporter activity
CBW65_RS13455	COG0586	Pfam SNARE associated Golgi protein
CBW65_RS13470	COG3377	Domain of unknown function (DUF1805)
CBW65_RS13485	COG1396	sequence-specific DNA binding
CBW65_RS13495	COG1363	Peptidase, m42
CBW65_RS13500	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CBW65_RS13520	COG2843	Capsule synthesis protein
CBW65_RS13530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CBW65_RS13550	COG0494	nUDIX hydrolase
CBW65_RS13575	COG1013	pyruvate-flavodoxin oxidoreductase activity
CBW65_RS13580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CBW65_RS13580	COG0674	pyruvate-flavodoxin oxidoreductase activity
CBW65_RS13585	COG1725	Transcriptional regulator
CBW65_RS13590	COG0584	glycerophosphoryl diester phosphodiesterase
CBW65_RS13595	COG5577	PFAM Coat F domain
CBW65_RS13610	COG0513	Belongs to the DEAD box helicase family
CBW65_RS13620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CBW65_RS13625	COG0352	thiamine-phosphate diphosphorylase activity
CBW65_RS13635	COG1131	(ABC) transporter
CBW65_RS13650	COG3584	3D domain protein
CBW65_RS13660	COG0674	pyruvate-flavodoxin oxidoreductase activity
CBW65_RS13660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CBW65_RS13665	COG1013	pyruvate-flavodoxin oxidoreductase activity
CBW65_RS13770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CBW65_RS13800	COG4122	O-methyltransferase activity
CBW65_RS13855	COG4974	Belongs to the 'phage' integrase family
CBW65_RS13915	COG1181	Belongs to the D-alanine--D-alanine ligase family
CBW65_RS13920	COG0189	ligase activity
CBW65_RS13945	COG2096	Adenosyltransferase
CBW65_RS13950	COG0647	UMP catabolic process
CBW65_RS13960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBW65_RS13965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CBW65_RS14005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBW65_RS14005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBW65_RS14025	COG0640	Transcriptional regulator
CBW65_RS14040	COG4294	response to UV
CBW65_RS14045	COG1252	NADH dehydrogenase
CBW65_RS14050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBW65_RS14055	COG1466	dna polymerase III delta subunit
CBW65_RS14065	COG0268	Binds directly to 16S ribosomal RNA
CBW65_RS14080	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_RS14095	COG1522	sequence-specific DNA binding
CBW65_RS14100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBW65_RS14105	COG0481	GTPase activity
CBW65_RS14115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBW65_RS14130	COG1420	regulation of RNA biosynthetic process
CBW65_RS14135	COG0459	protein refolding
CBW65_RS14140	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CBW65_RS14145	COG0443	Heat shock 70 kDa protein
CBW65_RS14155	COG2264	protein methyltransferase activity
CBW65_RS14160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CBW65_RS14165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBW65_RS14170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CBW65_RS14175	COG1283	sodium-dependent phosphate transmembrane transporter activity
CBW65_RS14180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CBW65_RS14185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CBW65_RS14190	COG1610	YqeY-like protein
CBW65_RS14195	COG1030	water channel activity
CBW65_RS14200	COG4864	UPF0365 protein
CBW65_RS14220	COG1702	phosphate starvation-inducible protein PhoH
CBW65_RS14225	COG1480	7TM receptor with intracellular HD hydrolase
CBW65_RS14230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CBW65_RS14235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CBW65_RS14245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CBW65_RS14255	COG1381	Involved in DNA repair and RecF pathway recombination
CBW65_RS14295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CBW65_RS14305	COG0517	IMP dehydrogenase activity
CBW65_RS14310	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CBW65_RS14315	COG0574	Belongs to the PEP-utilizing enzyme family
CBW65_RS14315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CBW65_RS14320	COG0358	DNA primase activity
CBW65_RS14325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CBW65_RS14335	COG1960	acyl-CoA dehydrogenase activity
CBW65_RS14345	COG0583	DNA-binding transcription factor activity
CBW65_RS14360	COG0583	DNA-binding transcription factor activity
CBW65_RS14365	COG2384	SAM-dependent methyltransferase
CBW65_RS14370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CBW65_RS14385	COG1272	protein, Hemolysin III
CBW65_RS14395	COG2169	Transcriptional regulator
CBW65_RS14405	COG0367	asparagine synthase
CBW65_RS14415	COG2329	Antibiotic biosynthesis monooxygenase
CBW65_RS14445	COG2268	Band 7 protein
CBW65_RS14450	COG1215	transferase activity, transferring glycosyl groups
CBW65_RS14470	COG0546	phosphoglycolate phosphatase activity
CBW65_RS14485	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CBW65_RS14490	COG0561	phosphatase activity
CBW65_RS14500	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CBW65_RS14505	COG1131	(ABC) transporter
CBW65_RS14510	COG2755	lipolytic protein G-D-S-L family
CBW65_RS14515	COG2323	membrane
CBW65_RS14520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CBW65_RS14525	COG0826	peptidase U32
CBW65_RS14535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CBW65_RS14535	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CBW65_RS14545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CBW65_RS14550	COG0512	Glutamine amidotransferase of anthranilate synthase
CBW65_RS14555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CBW65_RS14625	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CBW65_RS14655	COG4974	Belongs to the 'phage' integrase family
CBW65_RS14680	COG0582	viral genome integration into host DNA
CBW65_RS14720	COG1396	sequence-specific DNA binding
CBW65_RS14720	COG3800	Transcriptional regulator
CBW65_RS14770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBW65_RS14780	COG0745	RESPONSE REGULATOR receiver
CBW65_RS14800	COG3714	YhhN family
CBW65_RS14810	COG0583	DNA-binding transcription factor activity
CBW65_RS14830	COG2962	Rard protein
CBW65_RS14850	COG1132	(ABC) transporter
CBW65_RS14855	COG1132	(ABC) transporter
CBW65_RS14865	COG1285	pathogenesis
CBW65_RS14890	COG3279	Response regulator of the LytR AlgR family
CBW65_RS14895	COG0427	acetyl-CoA hydrolase
CBW65_RS14900	COG0726	polysaccharide deacetylase
CBW65_RS14925	COG0840	transmembrane signaling receptor activity
CBW65_RS14930	COG0583	DNA-binding transcription factor activity
CBW65_RS14935	COG0697	spore germination
CBW65_RS14965	COG2746	aminoglycoside 3-N-acetyltransferase activity
CBW65_RS14970	COG3507	Belongs to the glycosyl hydrolase 43 family
CBW65_RS14970	COG3693	PFAM glycoside hydrolase, family 10
CBW65_RS14970	COG2382	esterase
CBW65_RS14995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CBW65_RS15030	COG1073	alpha beta
CBW65_RS15035	COG0512	Glutamine amidotransferase of anthranilate synthase
CBW65_RS15045	COG1376	ErfK ybiS ycfS ynhG family protein
CBW65_RS15065	COG3442	glutamine amidotransferase
CBW65_RS15070	COG2814	Major facilitator Superfamily
CBW65_RS15075	COG2081	HI0933 family
CBW65_RS15110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CBW65_RS15130	COG0740	serine-type endopeptidase activity
CBW65_RS15140	COG1307	EDD domain protein, DegV family
CBW65_RS15155	COG0301	tRNA thio-modification
CBW65_RS15165	COG4224	UPF0291 protein
CBW65_RS15170	COG0454	-acetyltransferase
CBW65_RS15180	COG1011	Hydrolase
CBW65_RS15185	COG2815	serine threonine protein kinase
CBW65_RS15185	COG0515	serine threonine protein kinase
CBW65_RS15220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CBW65_RS15225	COG1695	Transcriptional regulator
CBW65_RS15235	COG2226	methyltransferase
CBW65_RS15245	COG0697	spore germination
CBW65_RS15250	COG0814	amino acid
CBW65_RS15270	COG1671	Belongs to the UPF0178 family
CBW65_RS15275	COG3854	ATPases associated with a variety of cellular activities
CBW65_RS15315	COG0511	ligase activity, forming carbon-carbon bonds
CBW65_RS15320	COG0439	Biotin carboxylase
CBW65_RS15325	COG1302	Protein conserved in bacteria
CBW65_RS15340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CBW65_RS15345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CBW65_RS15355	COG1570	exodeoxyribonuclease VII activity
CBW65_RS15360	COG1722	exodeoxyribonuclease VII activity
CBW65_RS15370	COG2323	membrane
CBW65_RS15375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CBW65_RS15380	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CBW65_RS15385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CBW65_RS15390	COG1438	arginine binding
CBW65_RS15395	COG0497	DNA recombination
CBW65_RS15400	COG0750	zinc metalloprotease
CBW65_RS15440	COG1595	DNA-templated transcription, initiation
CBW65_RS15470	COG4166	transmembrane transport
CBW65_RS15480	COG4166	transmembrane transport
CBW65_RS15495	COG2203	Gaf domain
CBW65_RS15495	COG2199	diguanylate cyclase activity
CBW65_RS15500	COG2267	carboxylic ester hydrolase activity
CBW65_RS15525	COG2086	electron transfer activity
CBW65_RS15530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CBW65_RS15535	COG0644	oxidoreductase
CBW65_RS15545	COG2153	protein acetylation
CBW65_RS15550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CBW65_RS15555	COG0488	(ABC) transporter
CBW65_RS15560	COG0725	ABC transporter, periplasmic molybdate-binding protein
CBW65_RS15565	COG4149	molybdate abc transporter
CBW65_RS15570	COG1217	gtp-binding protein TYPA
CBW65_RS15590	COG0316	Belongs to the HesB IscA family
CBW65_RS15595	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CBW65_RS15600	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS15605	COG2267	carboxylic ester hydrolase activity
CBW65_RS15615	COG0439	Biotin carboxylase
CBW65_RS15620	COG0511	ligase activity, forming carbon-carbon bonds
CBW65_RS15625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CBW65_RS15630	COG1024	Enoyl-CoA hydratase
CBW65_RS15635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CBW65_RS15640	COG4166	transmembrane transport
CBW65_RS15645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CBW65_RS15660	COG1733	regulation of RNA biosynthetic process
CBW65_RS15665	COG1902	pentaerythritol trinitrate reductase activity
CBW65_RS15670	COG2001	Belongs to the MraZ family
CBW65_RS15675	COG0275	rRNA processing
CBW65_RS15685	COG0768	penicillin binding
CBW65_RS15700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CBW65_RS15705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBW65_RS15710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CBW65_RS15715	COG0772	Belongs to the SEDS family
CBW65_RS15725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CBW65_RS15740	COG3879	Bacterial protein of unknown function (DUF881)
CBW65_RS15745	COG3856	small basic protein
CBW65_RS15750	COG0849	cell division
CBW65_RS15755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CBW65_RS15890	COG4974	Belongs to the 'phage' integrase family
CBW65_RS15905	COG1484	DNA-dependent DNA replication
CBW65_RS15965	COG0644	oxidoreductase
CBW65_RS15995	COG1191	sigma factor activity
CBW65_RS16000	COG1191	sigma factor activity
CBW65_RS16005	COG1873	PFAM PRC-barrel domain
CBW65_RS16015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CBW65_RS16020	COG1799	cell septum assembly
CBW65_RS16035	COG3599	regulation of cell shape
CBW65_RS16245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CBW65_RS16250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CBW65_RS16255	COG0564	pseudouridine synthase activity
CBW65_RS16260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CBW65_RS16270	COG0540	Belongs to the ATCase OTCase family
CBW65_RS16275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CBW65_RS16285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CBW65_RS16290	COG0543	2 iron, 2 sulfur cluster binding
CBW65_RS16295	COG0167	dihydroorotate dehydrogenase activity
CBW65_RS16300	COG0284	orotidine-5'-phosphate decarboxylase activity
CBW65_RS16325	COG2267	carboxylic ester hydrolase activity
CBW65_RS16330	COG0488	(ABC) transporter
CBW65_RS16340	COG0840	transmembrane signaling receptor activity
CBW65_RS16345	COG0697	spore germination
CBW65_RS16365	COG0277	FAD linked oxidase domain protein
CBW65_RS16400	COG2382	esterase
CBW65_RS16410	COG0189	ligase activity
CBW65_RS16415	COG0297	glycogen (starch) synthase activity
CBW65_RS16430	COG1131	(ABC) transporter
CBW65_RS16455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CBW65_RS16460	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CBW65_RS16465	COG1561	YicC-like family, N-terminal region
CBW65_RS16470	COG2052	Domain of unknown function (DUF370)
CBW65_RS16475	COG0194	GDP metabolic process
CBW65_RS16480	COG1758	RNA polymerase activity
CBW65_RS16485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CBW65_RS16490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CBW65_RS16495	COG0242	peptide deformylase activity
CBW65_RS16505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CBW65_RS16505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CBW65_RS16510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CBW65_RS16515	COG0631	protein serine/threonine phosphatase activity
CBW65_RS16520	COG2815	serine threonine protein kinase
CBW65_RS16520	COG0515	serine threonine protein kinase
CBW65_RS16525	COG1162	GTPase activity
CBW65_RS16530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CBW65_RS16540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CBW65_RS16545	COG1302	Protein conserved in bacteria
CBW65_RS16550	COG1461	Dihydroxyacetone kinase
CBW65_RS16555	COG1760	l-serine dehydratase
CBW65_RS16560	COG1760	l-serine dehydratase
CBW65_RS16565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CBW65_RS16590	COG0742	ribosomal rna small subunit methyltransferase
CBW65_RS16595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CBW65_RS16600	COG1752	Esterase of the alpha-beta hydrolase superfamily
CBW65_RS16605	COG3480	Lon protease (S16) C-terminal proteolytic domain
CBW65_RS16610	COG1323	Belongs to the UPF0348 family
CBW65_RS16620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CBW65_RS16630	COG0416	fatty acid biosynthetic process
CBW65_RS16635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBW65_RS16640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CBW65_RS16645	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS16650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CBW65_RS16660	COG0571	ribonuclease III activity
CBW65_RS16670	COG1196	nuclear chromosome segregation
CBW65_RS16675	COG0552	protein localization to endoplasmic reticulum
CBW65_RS16680	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CBW65_RS16685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CBW65_RS16690	COG0228	four-way junction DNA binding
CBW65_RS16695	COG1837	Belongs to the UPF0109 family
CBW65_RS16710	COG0336	Belongs to the RNA methyltransferase TrmD family
CBW65_RS16765	COG1376	ErfK ybiS ycfS ynhG family protein
CBW65_RS16770	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CBW65_RS16780	COG0335	large ribosomal subunit rRNA binding
CBW65_RS16785	COG0681	Belongs to the peptidase S26 family
CBW65_RS16795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CBW65_RS16805	COG2257	FlhB HrpN YscU SpaS Family
CBW65_RS16810	COG0792	nuclease activity
CBW65_RS16845	COG0606	chelatase, subunit chli
CBW65_RS16870	COG2814	Major facilitator Superfamily
CBW65_RS16890	COG0045	succinate-CoA ligase (ADP-forming) activity
CBW65_RS16895	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CBW65_RS16900	COG0758	DNA mediated transformation
CBW65_RS16905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CBW65_RS16910	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CBW65_RS16915	COG4974	Belongs to the 'phage' integrase family
CBW65_RS16920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CBW65_RS16925	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CBW65_RS16930	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CBW65_RS16935	COG1815	bacterial-type flagellum-dependent cell motility
CBW65_RS16940	COG1558	bacterial-type flagellum-dependent cell motility
CBW65_RS16955	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CBW65_RS16960	COG1317	bacterial-type flagellum organization
CBW65_RS16965	COG1157	protein secretion by the type III secretion system
CBW65_RS16985	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CBW65_RS16995	COG4786	Flagellar basal body rod
CBW65_RS17010	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CBW65_RS17015	COG1776	CheC inhibitor of MCP methylation
CBW65_RS17015	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CBW65_RS17020	COG2201	protein-glutamate methylesterase activity
CBW65_RS17030	COG1338	Plays a role in the flagellum-specific transport system
CBW65_RS17035	COG1987	bacterial-type flagellum assembly
CBW65_RS17040	COG1684	flagellar biosynthetic protein fliR
CBW65_RS17045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CBW65_RS17050	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CBW65_RS17055	COG1419	protein localization to endoplasmic reticulum
CBW65_RS17065	COG2201	protein-glutamate methylesterase activity
CBW65_RS17070	COG2198	Histidine kinase
CBW65_RS17070	COG0643	Histidine kinase
CBW65_RS17075	COG0835	chemotaxis
CBW65_RS17080	COG1776	CheC inhibitor of MCP methylation
CBW65_RS17085	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CBW65_RS17095	COG1191	sigma factor activity
CBW65_RS17120	COG0052	Belongs to the universal ribosomal protein uS2 family
CBW65_RS17125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CBW65_RS17130	COG0528	UMP kinase activity
CBW65_RS17135	COG0233	cytoplasmic translational termination
CBW65_RS17140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CBW65_RS17145	COG4589	Belongs to the CDS family
CBW65_RS17160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CBW65_RS17165	COG0584	glycerophosphoryl diester phosphodiesterase
CBW65_RS17170	COG0531	amino acid
CBW65_RS17185	COG0442	prolyl-tRNA aminoacylation
CBW65_RS17190	COG0463	Glycosyl transferase, family 2
CBW65_RS17195	COG2176	DNA-directed DNA polymerase activity
CBW65_RS17200	COG0779	Required for maturation of 30S ribosomal subunits
CBW65_RS17205	COG0195	Participates in both transcription termination and antitermination
CBW65_RS17220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CBW65_RS17230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CBW65_RS17235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CBW65_RS17240	COG0196	riboflavin kinase activity
CBW65_RS17255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CBW65_RS17260	COG1185	polyribonucleotide nucleotidyltransferase activity
CBW65_RS17270	COG0726	polysaccharide deacetylase
CBW65_RS17275	COG0612	Peptidase, M16
CBW65_RS17280	COG1873	PFAM PRC-barrel domain
CBW65_RS17285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBW65_RS17290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CBW65_RS17295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CBW65_RS17300	COG0527	aspartate kinase activity
CBW65_RS17305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CBW65_RS17310	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CBW65_RS17315	COG0740	serine-type endopeptidase activity
CBW65_RS17325	COG1674	ftsk spoiiie
CBW65_RS17325	COG4980	gas vesicle protein
CBW65_RS17330	COG2188	Transcriptional regulator
CBW65_RS17335	COG1744	ABC transporter substrate-binding protein PnrA-like
CBW65_RS17340	COG3845	ABC transporter
CBW65_RS17345	COG4603	Belongs to the binding-protein-dependent transport system permease family
CBW65_RS17350	COG1079	Belongs to the binding-protein-dependent transport system permease family
CBW65_RS17385	COG0477	Major facilitator Superfamily
CBW65_RS17420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBW65_RS17425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBW65_RS17430	COG1058	Belongs to the CinA family
CBW65_RS17430	COG1546	Belongs to the CinA family
CBW65_RS17445	COG2137	regulation of response to DNA damage stimulus
CBW65_RS17450	COG1418	mRNA catabolic process
CBW65_RS17460	COG1692	metallophosphoesterase
CBW65_RS17465	COG2359	stage V sporulation protein S
CBW65_RS17475	COG0613	PHP domain protein
CBW65_RS17480	COG4869	propanediol catabolic process
CBW65_RS17485	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CBW65_RS17510	COG0531	amino acid
CBW65_RS17515	COG0583	DNA-binding transcription factor activity
CBW65_RS17535	COG0189	ligase activity
CBW65_RS17555	COG0189	ligase activity
CBW65_RS17560	COG0384	phenazine biosynthesis protein PhzF
CBW65_RS17565	COG0688	phosphatidylethanolamine metabolic process
CBW65_RS17580	COG2112	serine threonine protein kinase
CBW65_RS17595	COG1061	Type III restriction enzyme res subunit
CBW65_RS17605	COG5582	Belongs to the UPF0302 family
CBW65_RS17620	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CBW65_RS17625	COG2010	Cytochrome c
CBW65_RS17625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CBW65_RS17640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBW65_RS17650	COG0586	Pfam SNARE associated Golgi protein
CBW65_RS17655	COG3949	Membrane
CBW65_RS17660	COG1968	undecaprenyl-diphosphatase activity
CBW65_RS17665	COG3314	Sporulation integral membrane protein YlbJ
CBW65_RS17670	COG1694	Mazg nucleotide pyrophosphohydrolase
CBW65_RS17675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CBW65_RS17680	COG1803	Methylglyoxal synthase
CBW65_RS17685	COG0617	tRNA 3'-terminal CCA addition
CBW65_RS17715	COG0784	Response regulator, receiver
CBW65_RS17715	COG3437	response regulator, receiver
CBW65_RS17735	COG0489	protein tyrosine kinase activity
CBW65_RS17740	COG4464	protein tyrosine phosphatase activity
CBW65_RS17760	COG1215	transferase activity, transferring glycosyl groups
CBW65_RS17765	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CBW65_RS17770	COG1316	TRANSCRIPTIONal
CBW65_RS17775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBW65_RS17785	COG3483	tryptophan 2,3-dioxygenase activity
CBW65_RS17800	COG0640	Transcriptional regulator
CBW65_RS17805	COG2226	methyltransferase
CBW65_RS17815	COG1222	aaa ATPase
CBW65_RS18000	COG0714	Associated with various cellular activities
CBW65_RS18150	COG1396	sequence-specific DNA binding
CBW65_RS18290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CBW65_RS18295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CBW65_RS18305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CBW65_RS18310	COG0134	indole-3-glycerol-phosphate synthase activity
CBW65_RS18315	COG0135	phosphoribosylanthranilate isomerase activity
CBW65_RS18320	COG0133	tryptophan synthase activity
CBW65_RS18330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CBW65_RS18345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CBW65_RS18355	COG0586	Pfam SNARE associated Golgi protein
CBW65_RS18370	COG1404	Belongs to the peptidase S8 family
CBW65_RS18375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBW65_RS18385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CBW65_RS18390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CBW65_RS18395	COG2136	Putative SAM-dependent methyltransferase
CBW65_RS18395	COG2521	methyltransferase
CBW65_RS18400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CBW65_RS18405	COG1923	regulation of RNA biosynthetic process
CBW65_RS18490	COG2409	Drug exporters of the RND superfamily
CBW65_RS18490	COG1033	growth of symbiont in host cell
CBW65_RS18495	COG1309	transcriptional regulator
CBW65_RS18500	COG0482	sulfurtransferase activity
CBW65_RS18525	COG5002	protein histidine kinase activity
CBW65_RS18655	COG0697	spore germination
CBW65_RS18660	COG0531	amino acid
CBW65_RS18735	COG4166	transmembrane transport
CBW65_RS18755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CBW65_RS18760	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CBW65_RS18765	COG0464	growth
CBW65_RS18770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CBW65_RS18795	COG0531	amino acid
CBW65_RS18810	COG0697	spore germination
CBW65_RS18830	COG3844	kynureninase activity
CBW65_RS18840	COG1741	Belongs to the pirin family
CBW65_RS18850	COG0693	protein deglycase activity
CBW65_RS18915	COG0493	'glutamate synthase
CBW65_RS18920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CBW65_RS18920	COG0167	dihydroorotate dehydrogenase activity
CBW65_RS18935	COG1953	Uracil, thiamine, allantoin
CBW65_RS18955	COG5337	Spore coat protein CotH
CBW65_RS18960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CBW65_RS18970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CBW65_RS19010	COG2986	histidine ammonia-lyase
CBW65_RS19020	COG1228	amidohydrolase
CBW65_RS19025	COG0010	Belongs to the arginase family
CBW65_RS19055	COG1404	Belongs to the peptidase S8 family
CBW65_RS19060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBW65_RS19110	COG2259	Doxx family
CBW65_RS19130	COG0477	Major facilitator Superfamily
CBW65_RS19150	COG0456	acetyltransferase
CBW65_RS19150	COG1846	Transcriptional regulator
CBW65_RS19155	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS19165	COG2738	Putative neutral zinc metallopeptidase
CBW65_RS19190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CBW65_RS19205	COG3858	chitin binding
CBW65_RS19205	COG1388	LysM domain
CBW65_RS19215	COG0363	glucosamine-6-phosphate deaminase activity
CBW65_RS19220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CBW65_RS19225	COG0395	ABC-type sugar transport system, permease component
CBW65_RS19230	COG1175	transmembrane transport
CBW65_RS19240	COG3876	Protein conserved in bacteria
CBW65_RS19245	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CBW65_RS19250	COG1472	Belongs to the glycosyl hydrolase 3 family
CBW65_RS19255	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CBW65_RS19260	COG2971	BadF BadG BcrA BcrD
CBW65_RS19265	COG2188	Transcriptional regulator
CBW65_RS19275	COG2385	sporulation resulting in formation of a cellular spore
CBW65_RS19275	COG2247	cell wall binding repeat
CBW65_RS19305	COG0559	Belongs to the binding-protein-dependent transport system permease family
CBW65_RS19315	COG0411	ABC transporter
CBW65_RS19325	COG0733	neurotransmitter:sodium symporter activity
CBW65_RS19330	COG0740	serine-type endopeptidase activity
CBW65_RS19345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBW65_RS19360	COG0318	PFAM AMP-dependent synthetase and ligase
CBW65_RS19365	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS19370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CBW65_RS19375	COG0174	glutamine synthetase
CBW65_RS19380	COG0789	Transcriptional regulator
CBW65_RS19385	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CBW65_RS19395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CBW65_RS19420	COG3266	domain, Protein
CBW65_RS19420	COG2911	Protein conserved in bacteria
CBW65_RS19420	COG1361	Conserved repeat domain
CBW65_RS19425	COG0488	(ABC) transporter
CBW65_RS19435	COG3935	DnaD domain protein
CBW65_RS19440	COG0017	Asparaginyl-tRNA synthetase
CBW65_RS19445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CBW65_RS19450	COG1250	3-hydroxyacyl-CoA dehydrogenase
CBW65_RS19460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBW65_RS19475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CBW65_RS19485	COG0402	S-adenosylhomocysteine deaminase activity
CBW65_RS19490	COG0235	Class ii aldolase
CBW65_RS19495	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CBW65_RS19500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CBW65_RS19510	COG1793	dna ligase
CBW65_RS19515	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CBW65_RS19520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CBW65_RS19530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CBW65_RS19530	COG1199	ATP-dependent helicase activity
CBW65_RS19550	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CBW65_RS19555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CBW65_RS19620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_RS19620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CBW65_RS19625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CBW65_RS19630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CBW65_RS19635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CBW65_RS19640	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CBW65_RS19640	COG0028	Belongs to the TPP enzyme family
CBW65_RS19665	COG3383	formate dehydrogenase (NAD+) activity
CBW65_RS19670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CBW65_RS19680	COG2207	Transcriptional regulator
CBW65_RS19680	COG1917	Cupin 2, conserved barrel domain protein
CBW65_RS19690	COG0589	response to stress
CBW65_RS19730	COG2329	Antibiotic biosynthesis monooxygenase
CBW65_RS19735	COG2855	membrane
CBW65_RS19745	COG0564	pseudouridine synthase activity
CBW65_RS19755	COG0438	transferase activity, transferring glycosyl groups
CBW65_RS19800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CBW65_RS19810	COG0105	UTP biosynthetic process
CBW65_RS19820	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CBW65_RS19830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CBW65_RS19835	COG0163	prenyltransferase activity
CBW65_RS19840	COG2226	methyltransferase
CBW65_RS19860	COG2155	Conserved Protein
CBW65_RS19880	COG0492	ferredoxin-NADP+ reductase activity
CBW65_RS19900	COG3695	enzyme binding
CBW65_RS19930	COG0488	(ABC) transporter
CBW65_RS19940	COG1484	DNA-dependent DNA replication
CBW65_RS20035	COG5549	protein import
CBW65_RS20035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBW65_RS20070	COG0179	Fumarylacetoacetate (FAA) hydrolase
CBW65_RS20085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CBW65_RS20095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CBW65_RS20100	COG0095	Lipoate-protein ligase
CBW65_RS20105	COG0509	glycine decarboxylation via glycine cleavage system
CBW65_RS20110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CBW65_RS20115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CBW65_RS20160	COG1304	FMN binding
CBW65_RS20175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CBW65_RS20195	COG2959	enzyme of heme biosynthesis
CBW65_RS20205	COG2339	peptidase activity
CBW65_RS20215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CBW65_RS20225	COG0626	cystathionine gamma-synthase activity
CBW65_RS20230	COG0626	cystathionine gamma-synthase activity
CBW65_RS20235	COG2814	Major facilitator Superfamily
CBW65_RS20260	COG1809	phosphosulfolactate synthase activity
CBW65_RS20265	COG2707	UPF0756 membrane protein
CBW65_RS20275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBW65_RS20280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CBW65_RS20285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBW65_RS20290	COG1609	Transcriptional regulator
CBW65_RS20300	COG4637	Psort location Cytoplasmic, score
CBW65_RS20305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CBW65_RS20340	COG3858	chitin binding
CBW65_RS20345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CBW65_RS20350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CBW65_RS20355	COG0438	transferase activity, transferring glycosyl groups
CBW65_RS20360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBW65_RS20370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CBW65_RS20405	COG0210	DNA helicase
CBW65_RS20420	COG3091	SprT-like family
CBW65_RS20430	COG0840	transmembrane signaling receptor activity
CBW65_RS20435	COG0705	Rhomboid family
CBW65_RS20435	COG0457	Tetratricopeptide repeat
CBW65_RS20450	COG0302	gtp cyclohydrolase
CBW65_RS20455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CBW65_RS20465	COG0726	polysaccharide deacetylase
CBW65_RS20470	COG1278	Cold shock
CBW65_RS20480	COG0300	oxidoreductase activity
CBW65_RS20485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CBW65_RS20490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CBW65_RS20495	COG0791	NLP P60 protein
CBW65_RS20495	COG1388	LysM domain
CBW65_RS20510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CBW65_RS20525	COG2814	Major facilitator Superfamily
CBW65_RS20535	COG0312	modulator of DNA gyrase
CBW65_RS20540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBW65_RS20570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBW65_RS20580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CBW65_RS20610	COG0431	NADPH-dependent FMN reductase
CBW65_RS20615	COG0681	Belongs to the peptidase S26 family
CBW65_RS20655	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CBW65_RS20675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CBW65_RS20680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CBW65_RS20685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CBW65_RS20710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CBW65_RS20725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CBW65_RS20730	COG2022	thiamine diphosphate biosynthetic process
CBW65_RS20740	COG0352	thiamine-phosphate diphosphorylase activity
CBW65_RS20750	COG1832	CoA-binding protein
CBW65_RS20760	COG5002	protein histidine kinase activity
CBW65_RS20765	COG0745	RESPONSE REGULATOR receiver
CBW65_RS20770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CBW65_RS20775	COG1333	cytochrome c biogenesis protein
CBW65_RS20780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_RS20790	COG1187	pseudouridine synthase activity
CBW65_RS20800	COG0700	Nucleoside recognition
CBW65_RS20805	COG2715	membrane protein required for spore maturation
CBW65_RS20810	COG1686	Belongs to the peptidase S11 family
CBW65_RS20815	COG3874	Sporulation protein YtfJ
CBW65_RS20825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CBW65_RS20830	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CBW65_RS20835	COG1994	Peptidase M50
CBW65_RS20840	COG0477	Major facilitator Superfamily
CBW65_RS20845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CBW65_RS20860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CBW65_RS20860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CBW65_RS20865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CBW65_RS20870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CBW65_RS20875	COG1686	Belongs to the peptidase S11 family
CBW65_RS20885	COG3409	Peptidoglycan-binding domain 1 protein
CBW65_RS20885	COG3773	Cell wall hydrolase
CBW65_RS20890	COG0019	diaminopimelate decarboxylase activity
CBW65_RS20895	COG0697	spore germination
CBW65_RS20910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBW65_RS20920	COG1191	sigma factor activity
CBW65_RS20930	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_RS20935	COG0446	pyridine nucleotide-disulphide oxidoreductase
CBW65_RS20940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_RS21005	COG2217	Heavy metal translocating P-type atpase
CBW65_RS21010	COG0840	transmembrane signaling receptor activity
CBW65_RS21030	COG0514	ATP-dependent DNA helicase (RecQ)
CBW65_RS21040	COG4187	Peptidase family M20/M25/M40
CBW65_RS21045	COG1686	Belongs to the peptidase S11 family
CBW65_RS21060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CBW65_RS21065	COG1366	Belongs to the anti-sigma-factor antagonist family
CBW65_RS21070	COG4974	Belongs to the 'phage' integrase family
CBW65_RS21080	COG0686	Belongs to the AlaDH PNT family
CBW65_RS21085	COG0735	belongs to the Fur family
CBW65_RS21100	COG1300	Membrane
CBW65_RS21105	COG1379	DNA repair
CBW65_RS21110	COG0494	nUDIX hydrolase
CBW65_RS21125	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBW65_RS21145	COG0697	spore germination
CBW65_RS21150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CBW65_RS21165	COG0840	transmembrane signaling receptor activity
CBW65_RS21170	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBW65_RS21180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CBW65_RS21185	COG0346	lactoylglutathione lyase activity
CBW65_RS21190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_RS21190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_RS21195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_RS21195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CBW65_RS21200	COG0180	Tryptophanyl-tRNA synthetase
CBW65_RS21215	COG0321	lipoyl(octanoyl) transferase activity
CBW65_RS21220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CBW65_RS21225	COG0508	dehydrogenase complex catalyzes the overall conversion of
CBW65_RS21230	COG0022	dehydrogenase e1 component
CBW65_RS21235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CBW65_RS21240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CBW65_RS21250	COG3829	transcription factor binding
CBW65_RS21250	COG3290	protein histidine kinase activity
CBW65_RS21265	COG3858	chitin binding
CBW65_RS21290	COG0521	Mo-molybdopterin cofactor biosynthetic process
CBW65_RS21295	COG0315	cyclic pyranopterin monophosphate synthase activity
CBW65_RS21300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CBW65_RS21305	COG0314	molybdopterin synthase activity
CBW65_RS21310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CBW65_RS21335	COG0697	spore germination
CBW65_RS21340	COG3361	conserved protein (COG2071)
CBW65_RS21350	COG0726	polysaccharide deacetylase
CBW65_RS21355	COG2223	nitrite transmembrane transporter activity
CBW65_RS21370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CBW65_RS21375	COG0006	proline dipeptidase activity
CBW65_RS21390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CBW65_RS21395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CBW65_RS21400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CBW65_RS21405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CBW65_RS21435	COG4492	Belongs to the UPF0735 family
CBW65_RS21440	COG0367	asparagine synthase
CBW65_RS21445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CBW65_RS21485	COG4970	Tfp pilus assembly protein FimT
CBW65_RS21490	COG4537	Required for transformation and DNA binding
CBW65_RS21505	COG1408	metallophosphoesterase
CBW65_RS21515	COG1619	proteins homologs of microcin C7 resistance protein MccF
CBW65_RS21525	COG0730	response to heat
CBW65_RS21535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CBW65_RS21545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CBW65_RS21555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CBW65_RS21560	COG1530	ribonuclease E activity
CBW65_RS21565	COG0750	zinc metalloprotease
CBW65_RS21575	COG2894	cell division
CBW65_RS21580	COG0850	regulation of cytokinetic process
CBW65_RS21585	COG0768	penicillin binding
CBW65_RS21595	COG1792	Involved in formation and maintenance of cell shape
CBW65_RS21600	COG1077	Cell shape determining protein MreB Mrl
CBW65_RS21610	COG0424	maF-like protein
CBW65_RS21615	COG1027	Aspartate ammonia-lyase
CBW65_RS21630	COG3584	3D domain protein
CBW65_RS21630	COG3583	domain protein
CBW65_RS21635	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CBW65_RS21650	COG0525	valine-tRNA ligase activity
CBW65_RS21660	COG1136	(ABC) transporter
CBW65_RS21660	COG0577	efflux transmembrane transporter activity
CBW65_RS21670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBW65_RS21675	COG1388	LysM domain
CBW65_RS21675	COG0791	NLP P60 protein
CBW65_RS21715	COG4912	Dna alkylation repair
CBW65_RS21735	COG1388	LysM domain
CBW65_RS21745	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CBW65_RS21775	COG0564	pseudouridine synthase activity
CBW65_RS21785	COG2233	PERMEase
CBW65_RS21790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CBW65_RS21795	COG0113	porphobilinogen synthase activity
CBW65_RS21805	COG0181	hydroxymethylbilane synthase activity
CBW65_RS21810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CBW65_RS21810	COG1648	precorrin-2 dehydrogenase activity
CBW65_RS21815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CBW65_RS21820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CBW65_RS21825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CBW65_RS21835	COG1116	anion transmembrane transporter activity
CBW65_RS21840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CBW65_RS21845	COG0697	spore germination
CBW65_RS21855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CBW65_RS21865	COG0470	DNA polymerase III
CBW65_RS21865	COG1067	ATP-dependent peptidase activity
CBW65_RS21870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CBW65_RS21875	COG0544	peptidyl-prolyl cis-trans isomerase activity
CBW65_RS21905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CBW65_RS21910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CBW65_RS21920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CBW65_RS21925	COG1846	Transcriptional regulator
CBW65_RS21930	COG2814	Major facilitator Superfamily
CBW65_RS21935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CBW65_RS21965	COG2197	response regulator
CBW65_RS21970	COG1406	Chemotaxis phosphatase CheX
CBW65_RS21975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CBW65_RS21980	COG1053	succinate dehydrogenase
CBW65_RS21985	COG2009	succinate dehydrogenase
CBW65_RS21990	COG0460	homoserine dehydrogenase
CBW65_RS21995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CBW65_RS22010	COG0322	excinuclease ABC activity
CBW65_RS22015	COG3118	belongs to the thioredoxin family
CBW65_RS22020	COG0071	Belongs to the small heat shock protein (HSP20) family
CBW65_RS22025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CBW65_RS22025	COG5322	oxidoreductase activity
CBW65_RS22040	COG0697	spore germination
CBW65_RS22050	COG1842	Phage shock protein A
CBW65_RS22055	COG4166	transmembrane transport
CBW65_RS22060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CBW65_RS22065	COG0454	-acetyltransferase
CBW65_RS22070	COG0517	IMP dehydrogenase activity
CBW65_RS22075	COG0123	including yeast histone deacetylase and acetoin utilization protein
CBW65_RS22085	COG1376	ErfK ybiS ycfS ynhG family protein
CBW65_RS22090	COG3278	Belongs to the heme-copper respiratory oxidase family
CBW65_RS22115	COG4585	Histidine kinase
CBW65_RS22120	COG2197	response regulator
CBW65_RS22135	COG4549	nuclear export factor GLE1
CBW65_RS22140	COG1605	Chorismate mutase
CBW65_RS22140	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CBW65_RS22145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CBW65_RS22150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CBW65_RS22160	COG0697	spore germination
CBW65_RS22175	COG1757	Na H antiporter
CBW65_RS22185	COG0741	lytic transglycosylase activity
CBW65_RS22190	COG0387	Pfam Sodium calcium exchanger
CBW65_RS22200	COG2827	Endonuclease containing a URI domain
CBW65_RS22205	COG1132	(ABC) transporter
CBW65_RS22210	COG1132	(ABC) transporter
CBW65_RS22255	COG0598	Magnesium transport protein CorA
CBW65_RS22265	COG0814	amino acid
CBW65_RS22270	COG0697	spore germination
CBW65_RS22290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CBW65_RS22300	COG0318	PFAM AMP-dependent synthetase and ligase
CBW65_RS22305	COG1024	Enoyl-CoA hydratase
CBW65_RS22315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CBW65_RS22320	COG0598	Magnesium transport protein CorA
CBW65_RS22325	COG0598	Magnesium transport protein CorA
CBW65_RS22345	COG1959	2 iron, 2 sulfur cluster binding
CBW65_RS22355	COG1801	Protein of unknown function DUF72
CBW65_RS22420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CBW65_RS22425	COG3437	response regulator, receiver
CBW65_RS22425	COG2770	Histidine kinase
CBW65_RS22430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CBW65_RS22435	COG1132	(ABC) transporter
CBW65_RS22440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBW65_RS22450	COG0626	cystathionine gamma-synthase activity
CBW65_RS22475	COG1061	Type III restriction enzyme res subunit
CBW65_RS22490	COG0601	transmembrane transport
CBW65_RS22495	COG1361	Conserved repeat domain
CBW65_RS22495	COG2911	Protein conserved in bacteria
CBW65_RS22495	COG3266	domain, Protein
CBW65_RS22500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CBW65_RS22525	COG0523	cobalamin synthesis protein
CBW65_RS22540	COG3436	PFAM IS66 Orf2 family protein
CBW65_RS22545	COG4372	Transposase
CBW65_RS22585	COG1484	DNA-dependent DNA replication
CBW65_RS22625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CBW65_RS22645	COG2323	membrane
CBW65_RS22655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CBW65_RS22660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CBW65_RS22665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CBW65_RS22675	COG1012	belongs to the aldehyde dehydrogenase family
CBW65_RS22705	COG0077	Prephenate dehydratase
CBW65_RS22710	COG0077	Prephenate dehydratase
CBW65_RS22710	COG1605	Chorismate mutase
CBW65_RS22715	COG0183	Belongs to the thiolase family
CBW65_RS22740	COG0714	Associated with various cellular activities
CBW65_RS22745	COG2084	Dehydrogenase
CBW65_RS22750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CBW65_RS22755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CBW65_RS22760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CBW65_RS22760	COG1321	iron dependent repressor
CBW65_RS22765	COG1121	(ABC) transporter
CBW65_RS22770	COG0803	Belongs to the bacterial solute-binding protein 9 family
CBW65_RS22775	COG1141	Ferredoxin
CBW65_RS22790	COG1595	DNA-templated transcription, initiation
CBW65_RS22820	COG1596	polysaccharide export
CBW65_RS22820	COG1555	photosystem II stabilization
CBW65_RS22825	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CBW65_RS22830	COG1321	iron dependent repressor
CBW65_RS22835	COG1181	Belongs to the D-alanine--D-alanine ligase family
CBW65_RS22845	COG0495	leucyl-tRNA aminoacylation
CBW65_RS22850	COG1388	LysM domain
CBW65_RS22850	COG3858	chitin binding
CBW65_RS22855	COG2226	methyltransferase
CBW65_RS22860	COG0799	negative regulation of ribosome biogenesis
CBW65_RS22865	COG1713	HD superfamily hydrolase involved in NAD metabolism
CBW65_RS22875	COG1534	Rna-binding protein
CBW65_RS22880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CBW65_RS22890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CBW65_RS22895	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CBW65_RS22905	COG1388	LysM domain
CBW65_RS22905	COG0791	NLP P60 protein
CBW65_RS22920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CBW65_RS22960	COG2814	Major facilitator Superfamily
CBW65_RS22980	COG0768	penicillin binding
CBW65_RS22985	COG0572	uridine kinase
CBW65_RS22990	COG4122	O-methyltransferase activity
CBW65_RS22995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CBW65_RS23005	COG3906	Belongs to the UPF0473 family
CBW65_RS23010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CBW65_RS23015	COG4472	Bacterial protein of unknown function (DUF965)
CBW65_RS23020	COG0628	permease
CBW65_RS23040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBW65_RS23045	COG0450	alkyl hydroperoxide reductase
CBW65_RS23080	COG1104	cysteine desulfurase activity
CBW65_RS23085	COG1959	2 iron, 2 sulfur cluster binding
CBW65_RS23090	COG2364	Membrane
CBW65_RS23110	COG0024	Methionine aminopeptidase
CBW65_RS23120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CBW65_RS23125	COG0124	histidyl-tRNA synthetase
CBW65_RS23135	COG2244	polysaccharide biosynthetic process
CBW65_RS23140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBW65_RS23145	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBW65_RS23150	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CBW65_RS23175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CBW65_RS23185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CBW65_RS23190	COG1418	mRNA catabolic process
CBW65_RS23200	COG1410	methionine synthase
CBW65_RS23200	COG0646	methionine synthase
CBW65_RS23235	COG1063	alcohol dehydrogenase
CBW65_RS23255	COG0531	amino acid
CBW65_RS23260	COG5002	protein histidine kinase activity
CBW65_RS23280	COG0427	acetyl-CoA hydrolase
CBW65_RS23285	COG2217	Heavy metal translocating P-type atpase
CBW65_RS23295	COG2814	Major facilitator Superfamily
CBW65_RS23345	COG1794	racemase activity, acting on amino acids and derivatives
CBW65_RS23435	COG2311	Membrane
CBW65_RS23455	COG1164	Oligoendopeptidase f
CBW65_RS23465	COG2205	protein histidine kinase activity
CBW65_RS23515	COG3290	protein histidine kinase activity
CBW65_RS23515	COG3829	transcription factor binding
CBW65_RS23520	COG2610	gluconate transmembrane transporter activity
CBW65_RS23525	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS23530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CBW65_RS23535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CBW65_RS23540	COG1794	racemase activity, acting on amino acids and derivatives
CBW65_RS23560	COG2807	transmembrane transport
CBW65_RS23565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CBW65_RS23570	COG0778	Nitroreductase
CBW65_RS23575	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CBW65_RS23585	COG0326	Molecular chaperone. Has ATPase activity
CBW65_RS23615	COG3878	Protein conserved in bacteria
CBW65_RS23640	COG1396	sequence-specific DNA binding
CBW65_RS23675	COG4372	Transposase
CBW65_RS23680	COG3436	PFAM IS66 Orf2 family protein
CBW65_RS23750	COG0697	spore germination
CBW65_RS23755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CBW65_RS23760	COG2814	Major facilitator Superfamily
CBW65_RS23780	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CBW65_RS23800	COG1490	D-aminoacyl-tRNA deacylase activity
CBW65_RS23805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CBW65_RS23810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CBW65_RS23815	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CBW65_RS23815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CBW65_RS23820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBW65_RS23825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBW65_RS23840	COG2244	polysaccharide biosynthetic process
CBW65_RS23845	COG2323	membrane
CBW65_RS23850	COG3706	GGDEF domain
CBW65_RS23860	COG1862	Preprotein translocase
CBW65_RS23865	COG0343	queuine tRNA-ribosyltransferase activity
CBW65_RS23870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CBW65_RS23875	COG2385	sporulation resulting in formation of a cellular spore
CBW65_RS23885	COG4447	cellulose binding
CBW65_RS23890	COG1191	sigma factor activity
CBW65_RS23895	COG2255	four-way junction helicase activity
CBW65_RS23900	COG0632	four-way junction helicase activity
CBW65_RS23920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CBW65_RS23925	COG2211	Major facilitator Superfamily
CBW65_RS23930	COG2814	Major facilitator Superfamily
CBW65_RS23940	COG1028	Short-chain dehydrogenase reductase Sdr
CBW65_RS23960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system