locus-tag	class	description
HLK68_RS00005	ENOG4105CT2	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HLK68_RS00015	ENOG41082AN	stage II sporulation protein
HLK68_RS00020	ENOG4105DZ1	carboxypeptidase
HLK68_RS00025	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HLK68_RS00045	ENOG4107RIS	Acyl-transferase
HLK68_RS00050	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HLK68_RS00055	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HLK68_RS00060	ENOG4107YX5	Pfam:DUF548
HLK68_RS00065	ENOG4105CT4	transporter
HLK68_RS00070	ENOG4105Z8H	single-stranded DNA-binding protein
HLK68_RS00085	ENOG4105K4I	Scp-like extracellular
HLK68_RS00090	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HLK68_RS00095	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HLK68_RS00100	ENOG4105C02	permease
HLK68_RS00115	ENOG4105CUZ	uba thif-type nad fad binding protein
HLK68_RS00130	ENOG4105F9F	transposase
HLK68_RS00145	ENOG4105E0M	Sulfatase
HLK68_RS00150	ENOG4105EJV	Membrane
HLK68_RS00170	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HLK68_RS00185	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HLK68_RS00190	ENOG4105K64	Glycosyl transferase, family 2
HLK68_RS00200	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HLK68_RS00225	ENOG4108KGH	TRANSCRIPTIONal
HLK68_RS00245	ENOG4105CUT	histidyl-tRNA synthetase
HLK68_RS00250	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HLK68_RS00255	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HLK68_RS00260	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HLK68_RS00265	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HLK68_RS00270	ENOG4105CKP	Polysaccharide Biosynthesis Protein
HLK68_RS00275	ENOG4108QG2	Membrane
HLK68_RS00285	ENOG4105VIE	preprotein translocase, subunit YajC
HLK68_RS00290	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HLK68_RS00295	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HLK68_RS00310	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HLK68_RS00315	ENOG4105TMB	Formate nitrite transporter
HLK68_RS00345	ENOG4105C8Y	Acetylornithine aminotransferase
HLK68_RS00350	ENOG4105CFP	Peptidase U32
HLK68_RS00355	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HLK68_RS00370	ENOG4107QM2	Aldo Keto reductase
HLK68_RS00415	ENOG4105C8J	)-transporter
HLK68_RS00720	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
HLK68_RS00740	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HLK68_RS00765	ENOG4105NBR	Pectinesterase
HLK68_RS00775	ENOG4105F9F	transposase
HLK68_RS00795	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HLK68_RS00805	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
HLK68_RS00810	ENOG4108JQ7	(ABC) transporter
HLK68_RS00815	ENOG4105C3U	ABC transporter
HLK68_RS00830	ENOG4105DEF	Extracellular solute-binding protein, family 5
HLK68_RS00835	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HLK68_RS00840	ENOG4105DKQ	ROK family
HLK68_RS00855	ENOG4107SCR	N-acetylneuraminate lyase
HLK68_RS00865	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLK68_RS00870	ENOG4105K46	50S ribosomal protein l27
HLK68_RS00880	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HLK68_RS00885	ENOG4105BZU	Histidine kinase
HLK68_RS00890	ENOG4108Z4T	Peptidase M50
HLK68_RS00925	ENOG4105W5Q	DNA repair protein (RadC
HLK68_RS00935	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HLK68_RS00960	ENOG4105CN9	Peptidase m42 family protein
HLK68_RS00965	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HLK68_RS00970	ENOG4105VJV	50s ribosomal protein L35
HLK68_RS00975	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HLK68_RS00985	ENOG4105C22	threonyL-tRNA synthetase
HLK68_RS01005	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HLK68_RS01025	ENOG4105DPN	Oligoendopeptidase f
HLK68_RS01030	ENOG4108XXK	NUDIX hydrolase
HLK68_RS01035	ENOG4105KFN	sortase, SrtB family
HLK68_RS01045	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HLK68_RS01050	ENOG4105C2M	dna polymerase I
HLK68_RS01065	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HLK68_RS01085	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HLK68_RS01105	ENOG4105EAH	synthase
HLK68_RS01110	ENOG4105CEP	NADH dehydrogenase
HLK68_RS01130	ENOG4108Z4K	mutator MutT protein
HLK68_RS01135	ENOG4105CA9	Pyruvate kinase
HLK68_RS01140	ENOG4105CTQ	phosphohexokinase
HLK68_RS01145	ENOG4105C0B	DNA polymerase III (alpha subunit)
HLK68_RS01150	ENOG4105SFS	phosphoesterase RecJ domain protein
HLK68_RS01155	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HLK68_RS01165	ENOG4105KBJ	sporulation protein ytfj
HLK68_RS01175	ENOG4105CAQ	asparagine synthetase
HLK68_RS01180	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HLK68_RS01185	ENOG4105EN6	Membrane
HLK68_RS01190	ENOG4105C5H	ABC transporter
HLK68_RS01195	ENOG4105DFM	M18 family aminopeptidase
HLK68_RS01265	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HLK68_RS01270	ENOG4105D7W	serine acetyltransferase
HLK68_RS01290	ENOG4105CAY	ferredoxin--nadp reductase
HLK68_RS01300	ENOG4108W5N	phosphatidylglycerophosphatase a
HLK68_RS01310	ENOG41083MR	nifu domain-containing protein
HLK68_RS01315	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HLK68_RS01320	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
HLK68_RS01325	ENOG4105MMD	transcriptional regulator
HLK68_RS01330	ENOG4108YTE	sporulation protein YunB
HLK68_RS01340	ENOG4105UQX	Mate efflux family protein
HLK68_RS01345	ENOG4105ETE	Transcriptional regulator (LacI family
HLK68_RS01355	ENOG4105CDA	abc transporter atp-binding protein
HLK68_RS01360	ENOG4105E5Q	amino acid AbC transporter
HLK68_RS01385	ENOG4105DQ6	Transposase
HLK68_RS01395	ENOG4105EMS	pseudouridine synthase
HLK68_RS01400	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HLK68_RS01410	ENOG4105MIX	Adenylate cyclase
HLK68_RS01425	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
HLK68_RS01430	ENOG4108JQ7	(ABC) transporter
HLK68_RS01440	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HLK68_RS01445	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HLK68_RS01460	ENOG4105BZ1	(ABC) transporter
HLK68_RS01465	ENOG4105BZ1	(ABC) transporter
HLK68_RS01475	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HLK68_RS01480	ENOG4108KP7	hydrolase
HLK68_RS01485	ENOG4105C8T	Leucyl-tRNA synthetase
HLK68_RS01490	ENOG4105N5T	Radical SAM Protein
HLK68_RS01520	ENOG4105CP7	Triose-phosphate isomerase
HLK68_RS01525	ENOG4105ESV	Glycosyl transferase, family 4
HLK68_RS01530	ENOG4105CQZ	Histidine kinase
HLK68_RS01535	ENOG4105E1K	spore germination protein
HLK68_RS01575	ENOG4105CJZ	response regulator
HLK68_RS01580	ENOG4105E5G	Alpha beta hydrolase fold
HLK68_RS01600	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HLK68_RS01615	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HLK68_RS01620	ENOG4107S6Z	Na H antiporter
HLK68_RS01655	ENOG4105E1K	spore germination protein
HLK68_RS01660	ENOG4105CMQ	Chloride channel
HLK68_RS01685	ENOG4105D3R	alkyl hydroperoxide reductase
HLK68_RS01730	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HLK68_RS01790	ENOG4107T8Q	Glycosyl transferase (Group 1
HLK68_RS01810	ENOG4107YSK	Glycerol-3-phosphate cytidylyltransferase
HLK68_RS01830	ENOG4108KMV	Glycosyl transferase (Group 1
HLK68_RS01835	ENOG41068W6	Capsular polysaccharide biosynthesis protein
HLK68_RS01840	ENOG4107SJB	teichoic acid biosynthesis
HLK68_RS01845	ENOG4105CG5	Glycosyl transferase (Group 1
HLK68_RS01860	ENOG4105D3Q	Sugar transferase
HLK68_RS01865	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HLK68_RS01875	ENOG4107YJ4	chain length determinant protein
HLK68_RS01890	ENOG4105DIN	metallophosphoesterase
HLK68_RS01895	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HLK68_RS01900	ENOG4108KGH	TRANSCRIPTIONal
HLK68_RS01930	ENOG4105D3Q	Sugar transferase
HLK68_RS01935	ENOG4107YJ4	chain length determinant protein
HLK68_RS01940	ENOG4105HTX	biosynthesis protein
HLK68_RS01945	ENOG4105BZ1	(ABC) transporter
HLK68_RS02000	ENOG4105D3Q	Sugar transferase
HLK68_RS02005	ENOG4107YJ4	chain length determinant protein
HLK68_RS02030	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HLK68_RS02055	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HLK68_RS02070	ENOG4105DY9	regulatoR
HLK68_RS02075	ENOG4105BZU	Histidine kinase
HLK68_RS02095	ENOG4105KIS	phospholipid-binding protein
HLK68_RS02105	ENOG4105DWF	phosphomethylpyrimidine kinase
HLK68_RS02110	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HLK68_RS02115	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
HLK68_RS02125	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HLK68_RS02130	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HLK68_RS02135	ENOG4105DM4	PTS System
HLK68_RS02140	ENOG4105DM4	PTS System
HLK68_RS02165	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HLK68_RS02175	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HLK68_RS02185	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HLK68_RS02210	ENOG4105CC5	ABC transporter
HLK68_RS02215	ENOG4105DIK	(ABC) transporter
HLK68_RS02220	ENOG4105CC5	ABC transporter
HLK68_RS02225	ENOG4105DIK	(ABC) transporter
HLK68_RS02230	ENOG4105DSE	periplasmic solute binding protein
HLK68_RS02245	ENOG4108Q3X	Transcriptional regulator
HLK68_RS02250	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HLK68_RS02265	ENOG4105C0A	alcohol dehydrogenase
HLK68_RS02275	ENOG4107414	GntR family transcriptional regulator
HLK68_RS02280	ENOG4105CG3	alpha amylase, catalytic region
HLK68_RS02285	ENOG4105C5Y	PTS System
HLK68_RS02305	ENOG4105FTV	AraC Family Transcriptional Regulator
HLK68_RS02310	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HLK68_RS02330	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HLK68_RS02340	ENOG4105CIG	ABC transporter
HLK68_RS02365	ENOG4107RBB	ABC transporter, permease
HLK68_RS02370	ENOG4105C19	ABC transporter
HLK68_RS02380	ENOG4108X4Q	Hydrolase
HLK68_RS02385	ENOG4105E98	transcriptional regulator DeoR family
HLK68_RS02395	ENOG4105C2F	Histidine kinase
HLK68_RS02400	ENOG4105EQD	regulatoR
HLK68_RS02420	ENOG4105F9F	transposase
HLK68_RS02425	ENOG4105C4C	beta-galactosidase
HLK68_RS02430	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HLK68_RS02440	ENOG4105C37	(CBS) domain
HLK68_RS02455	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HLK68_RS02480	ENOG4105CV8	reductase
HLK68_RS02500	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HLK68_RS02505	ENOG4105CPN	adenine deaminase
HLK68_RS02510	ENOG4107RUE	extracellular solute-binding protein family 1
HLK68_RS02515	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HLK68_RS02520	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HLK68_RS02525	ENOG4105F38	ABC transporter, permease
HLK68_RS02530	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HLK68_RS02550	ENOG4107R4J	Chloride channel
HLK68_RS02555	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HLK68_RS02565	ENOG4105DKQ	ROK family
HLK68_RS02570	ENOG41066F8	ROK family
HLK68_RS02590	ENOG4105C8I	hydrolase, family 38
HLK68_RS02600	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HLK68_RS02615	ENOG4105C2F	Histidine kinase
HLK68_RS02625	ENOG4105DG6	mannose-6-phosphate isomerase
HLK68_RS02630	ENOG4105CS2	ec 3.2.1.21
HLK68_RS02640	ENOG4105C19	ABC transporter
HLK68_RS02645	ENOG4105EWM	Histidine kinase
HLK68_RS02650	ENOG4105CJZ	response regulator
HLK68_RS02670	ENOG4105EPR	degv family
HLK68_RS02675	ENOG4108ZJ4	polysaccharide deacetylase
HLK68_RS02690	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
HLK68_RS02695	ENOG4107YHD	transcriptional regulator
HLK68_RS02705	ENOG4105CAX	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)
HLK68_RS02725	ENOG4105CDA	abc transporter atp-binding protein
HLK68_RS02730	ENOG4105DSP	amino acid AbC transporter
HLK68_RS02735	ENOG4105E5Q	amino acid AbC transporter
HLK68_RS02755	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HLK68_RS02765	ENOG4105EJQ	L-serine dehydratase
HLK68_RS02770	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HLK68_RS02775	ENOG4105CN1	protease
HLK68_RS02785	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HLK68_RS02790	ENOG4105CAK	Cell division ATP-binding protein ftsE
HLK68_RS02795	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HLK68_RS02800	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HLK68_RS02810	ENOG4105MS2	ribosomal subunit Interface protein
HLK68_RS02825	ENOG4105DE4	1-phosphofructokinase
HLK68_RS02850	ENOG4105EPR	degv family
HLK68_RS02855	ENOG4105EPR	degv family
HLK68_RS02860	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HLK68_RS02865	ENOG4105D1H	recombination factor protein RarA
HLK68_RS02870	ENOG4105DFF	Rod shape-determining protein mreb
HLK68_RS02890	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HLK68_RS02895	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HLK68_RS02905	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HLK68_RS02915	ENOG4107ZFM	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HLK68_RS02920	ENOG41085E0	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HLK68_RS02925	ENOG4107WJT	it plays a direct role in the translocation of protons across the membrane (By similarity)
HLK68_RS02940	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HLK68_RS02945	ENOG4108YZG	isomerase
HLK68_RS02960	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HLK68_RS02965	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HLK68_RS02970	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HLK68_RS02975	ENOG4105CDU	Replicative dna helicase
HLK68_RS02980	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HLK68_RS02985	ENOG4105BZR	domain protein
HLK68_RS03005	ENOG4108UUM	single-stranded DNA-binding protein
HLK68_RS03020	ENOG4105S7S	phosphonate abc transporter
HLK68_RS03025	ENOG4105D5T	phosphonate abc transporter
HLK68_RS03035	ENOG4105C3G	gtp-binding protein
HLK68_RS03045	ENOG4107QZ7	Cellulose synthase catalytic subunit
HLK68_RS03055	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HLK68_RS03070	ENOG4106A3R	peptidase
HLK68_RS03075	ENOG4105CZX	twitching motility protein
HLK68_RS03120	ENOG4105D7Q	type ii secretion system
HLK68_RS03125	ENOG4107QHF	type ii secretion system protein e
HLK68_RS03135	ENOG4105BZ4	penicillin-binding protein
HLK68_RS03150	ENOG4105C0H	protease
HLK68_RS03155	ENOG4105F8V	Hydrolase, tatD family
HLK68_RS03160	ENOG4108JQ7	(ABC) transporter
HLK68_RS03170	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HLK68_RS03175	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HLK68_RS03180	ENOG4108J59	Extracellular solute-binding protein, family 5
HLK68_RS03200	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HLK68_RS03205	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HLK68_RS03215	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HLK68_RS03220	ENOG41060K3	Methyltransferase
HLK68_RS03225	ENOG4105MA4	psp1 domain protein
HLK68_RS03230	ENOG4105FA2	dna polymerase iii
HLK68_RS03235	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HLK68_RS03250	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HLK68_RS03255	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
HLK68_RS03260	ENOG4108JJB	ABC transporter
HLK68_RS03265	ENOG4108JJB	ABC transporter
HLK68_RS03275	ENOG4105BZ1	(ABC) transporter
HLK68_RS03280	ENOG4105D3R	alkyl hydroperoxide reductase
HLK68_RS03410	ENOG4108UJD	30S ribosomal protein S9
HLK68_RS03425	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HLK68_RS03430	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HLK68_RS03435	ENOG4105C6E	dna polymerase iii
HLK68_RS03440	ENOG4107QJQ	Mate efflux family protein
HLK68_RS03450	ENOG4105VUF	Transcriptional regulator
HLK68_RS03455	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HLK68_RS03465	ENOG4105E2Z	phosphate ABC transporter (Permease
HLK68_RS03470	ENOG4105C8U	phosphate abc transporter
HLK68_RS03475	ENOG4107S17	Phosphate-binding protein
HLK68_RS03480	ENOG4105BZU	Histidine kinase
HLK68_RS03485	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HLK68_RS03495	ENOG4108Z6B	deaminase
HLK68_RS03510	ENOG4105ZMH	deoxynucleoside kinase
HLK68_RS03525	ENOG4105CE1	Ferrous iron transport protein b
HLK68_RS03540	ENOG4107104	thymidine kinase
HLK68_RS03545	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HLK68_RS03550	ENOG4105CH2	amidohydrolase
HLK68_RS03555	ENOG4105BZU	Histidine kinase
HLK68_RS03580	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HLK68_RS03585	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HLK68_RS03590	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HLK68_RS03595	ENOG4107TXC	Transcriptional regulator
HLK68_RS03600	ENOG4105DMC	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3
HLK68_RS03610	ENOG4105VFB	Binds the 23S rRNA (By similarity)
HLK68_RS03615	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HLK68_RS03630	ENOG4105C6K	Malic enzyme
HLK68_RS03640	ENOG4108RE9	Phosphodiesterase
HLK68_RS03660	ENOG4105C5F	glutamine synthetase
HLK68_RS03670	ENOG4105CHR	reductase
HLK68_RS03680	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HLK68_RS03685	ENOG4105KVH	Transcriptional regulator
HLK68_RS03720	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HLK68_RS03730	ENOG4105CD3	dihydroorotase
HLK68_RS03760	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HLK68_RS03765	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HLK68_RS03770	ENOG4105TMB	Formate nitrite transporter
HLK68_RS03780	ENOG4105CNW	domain protein
HLK68_RS03785	ENOG4105C0A	alcohol dehydrogenase
HLK68_RS03790	ENOG4107RVG	penicillin-binding protein
HLK68_RS03800	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HLK68_RS03815	ENOG4105C7N	Xanthine uracil vitamin C permease
HLK68_RS03830	ENOG4105DER	m42 family
HLK68_RS03835	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HLK68_RS03870	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLK68_RS03880	ENOG4105EEI	dihydropteroate synthase
HLK68_RS03885	ENOG4108RAC	Rubrerythrin
HLK68_RS03895	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HLK68_RS03930	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
HLK68_RS03960	ENOG4108IPW	abc transporter atp-binding protein
HLK68_RS03965	ENOG4105CM4	permease protein
HLK68_RS03970	ENOG4105DHS	permease protein
HLK68_RS03975	ENOG4105ID8	Transcriptional regulator, ARAC family
HLK68_RS03995	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HLK68_RS04000	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HLK68_RS04005	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HLK68_RS04015	ENOG4105G3A	stage ii sporulation protein e
HLK68_RS04020	ENOG4105UQX	Mate efflux family protein
HLK68_RS04025	ENOG410811P	TRANSCRIPTIONAl REGULATOR GntR family
HLK68_RS04030	ENOG4105DA5	(ABC) transporter
HLK68_RS04040	ENOG41060GV	RNA binding s1 domain protein
HLK68_RS04055	ENOG4105VYY	sporulation protein yabp
HLK68_RS04070	ENOG41082I2	s4 domain protein
HLK68_RS04075	ENOG4108IY2	MazG family
HLK68_RS04095	ENOG4105KNA	-acetyltransferase
HLK68_RS04105	ENOG4105BZ1	(ABC) transporter
HLK68_RS04115	ENOG4105K56	Transcriptional regulator
HLK68_RS04120	ENOG4105DWD	nucleoside recognition domain protein
HLK68_RS04125	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HLK68_RS04150	ENOG4108VXD	carboxy-peptidase
HLK68_RS04175	ENOG4105DQ6	Transposase
HLK68_RS04230	ENOG4105C5R	Aminotransferase
HLK68_RS04235	ENOG4105C12	Phosphoribosylglycinamide synthetase
HLK68_RS04240	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HLK68_RS04245	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HLK68_RS04250	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HLK68_RS04260	ENOG4105C8V	SAICAR synthetase
HLK68_RS04270	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HLK68_RS04275	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HLK68_RS04285	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HLK68_RS04290	ENOG4108M14	stage v sporulation protein t
HLK68_RS04295	ENOG4108JA2	transcriptioN-repair coupling factor
HLK68_RS04300	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HLK68_RS04305	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HLK68_RS04310	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HLK68_RS04315	ENOG4105K4W	Could be involved in septation (By similarity)
HLK68_RS04320	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HLK68_RS04325	ENOG4105W42	Veg protein
HLK68_RS04330	ENOG4105XFA	sporulation peptidase YabG
HLK68_RS04335	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HLK68_RS04345	ENOG4105DCI	Phosphohydrolase
HLK68_RS04360	ENOG4108IJ2	phosphate acetyltransferase
HLK68_RS04365	ENOG4108VKI	Cell wall hydrolase
HLK68_RS04375	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HLK68_RS04390	ENOG4105K59	histidine triad (HIT) protein
HLK68_RS04400	ENOG4105EAH	synthase
HLK68_RS04405	ENOG410667J	hydrolase
HLK68_RS04410	ENOG4108RAC	Rubrerythrin
HLK68_RS04415	ENOG4108RAC	Rubrerythrin
HLK68_RS04420	ENOG4105F1A	Pyruvate formate-lyase
HLK68_RS04435	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HLK68_RS04440	ENOG4108UMI	ABC transporter, permease
HLK68_RS04445	ENOG4105D01	(LipO)protein
HLK68_RS04450	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HLK68_RS04470	ENOG4107QI1	Mate efflux family protein
HLK68_RS04485	ENOG4105WEF	catalase
HLK68_RS04490	ENOG4105CHH	sulfate transporter
HLK68_RS04495	ENOG4105C1J	atp-dependent rna helicase
HLK68_RS04500	ENOG4105C5H	ABC transporter
HLK68_RS04535	ENOG4108115	UPF0145 protein
HLK68_RS04550	ENOG4105KVH	Transcriptional regulator
HLK68_RS04575	ENOG4108AEY	RNA polymerase sigma factor
HLK68_RS04585	ENOG4105CDY	transcriptional regulatory protein
HLK68_RS04630	ENOG4108KD5	ADP-ribosylation crystallin J1
HLK68_RS04635	ENOG4108TFM	Kinase, PfkB family
HLK68_RS04640	ENOG4107XDY	Nicotinamide Mononucleotide Transporter
HLK68_RS04645	ENOG4105DG6	mannose-6-phosphate isomerase
HLK68_RS04650	ENOG4105VCP	PTS System
HLK68_RS04655	ENOG41066F8	ROK family
HLK68_RS04660	ENOG4105CS2	ec 3.2.1.21
HLK68_RS04665	ENOG4105CK1	PTS System
HLK68_RS04670	ENOG4105VZJ	PTS System
HLK68_RS04675	ENOG4105DKQ	ROK family
HLK68_RS04680	ENOG4108S3Y	transcriptional regulator
HLK68_RS04685	ENOG4108VXD	carboxy-peptidase
HLK68_RS04690	ENOG4105EMN	RNA polymerase sigma factor
HLK68_RS04715	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HLK68_RS04730	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HLK68_RS04735	ENOG4105C2I	pirin domain protein
HLK68_RS04740	ENOG4105CFC	Transporter
HLK68_RS04755	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HLK68_RS04775	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
HLK68_RS04780	ENOG4105CGH	5'-nucleotidase
HLK68_RS04800	ENOG41090E6	transcriptional regulator MERR family
HLK68_RS04820	ENOG4107UWA	esterase
HLK68_RS04845	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HLK68_RS04865	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HLK68_RS04875	ENOG4105BZU	Histidine kinase
HLK68_RS04880	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HLK68_RS04895	ENOG4105FCD	Major Facilitator
HLK68_RS04920	ENOG4105DDN	Pentapeptide repeat-containing protein
HLK68_RS04935	ENOG4105D6U	Sodium Glutamate Symporter
HLK68_RS04940	ENOG4108X4Q	Hydrolase
HLK68_RS04960	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HLK68_RS04975	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
HLK68_RS05000	ENOG4105Q2H	domain protein
HLK68_RS05005	ENOG4105DR5	peptidase
HLK68_RS05010	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HLK68_RS05015	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HLK68_RS05020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HLK68_RS05025	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HLK68_RS05030	ENOG410848D	S4 domain protein YaaA
HLK68_RS05035	ENOG4105VDK	protein, conserved in bacteria
HLK68_RS05040	ENOG4105D8X	mechanosensitive ion channel
HLK68_RS05045	ENOG4105FA0	parb-like partition protein
HLK68_RS05050	ENOG4107QJE	Chromosome Partitioning Protein
HLK68_RS05055	ENOG410636K	Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity)
HLK68_RS05060	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HLK68_RS05070	ENOG4108IUX	(ABC) transporter
HLK68_RS05075	ENOG4105RHA	ABC transporter, permease
HLK68_RS05080	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HLK68_RS05090	ENOG4105VG0	50S ribosomal protein l34
HLK68_RS05105	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HLK68_RS05115	ENOG4105CU9	asparagine synthetase A
HLK68_RS05120	ENOG4105C5S	asparaginyl-tRNA synthetase
HLK68_RS05145	ENOG4108IUM	Glycogen debranching enzyme
HLK68_RS05150	ENOG4105BZU	Histidine kinase
HLK68_RS05160	ENOG4105C75	arginyL-tRNA synthetase
HLK68_RS05190	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HLK68_RS05200	ENOG4105BZU	Histidine kinase
HLK68_RS05205	ENOG4105DZ0	fad dependent oxidoreductase
HLK68_RS05230	ENOG4105F3H	Histidine kinase
HLK68_RS05235	ENOG4105C83	adenylosuccinate lyase
HLK68_RS05240	ENOG4105NAE	bifunctional deaminase-reductase domain protein
HLK68_RS05245	ENOG41067QW	Transcriptional regulator
HLK68_RS05250	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HLK68_RS05255	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HLK68_RS05295	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HLK68_RS05305	ENOG4105CG3	alpha amylase, catalytic region
HLK68_RS05315	ENOG41081HM	2'-5' rna ligase
HLK68_RS05340	ENOG4105BZU	Histidine kinase
HLK68_RS05350	ENOG4105EMN	RNA polymerase sigma factor
HLK68_RS05360	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HLK68_RS05365	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HLK68_RS05380	ENOG4107RWR	Sodium hydrogen exchanger
HLK68_RS05390	ENOG4105CBT	Fructose-1,6-bisphosphatase
HLK68_RS05395	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HLK68_RS05405	ENOG4105K7K	Transcriptional regulator
HLK68_RS05420	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HLK68_RS05425	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HLK68_RS05440	ENOG4105KME	endoribonuclease L-psp
HLK68_RS05445	ENOG4105C7B	Threonine dehydratase
HLK68_RS05450	ENOG4105C8N	cysteinyl-tRNA synthetase
HLK68_RS05455	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HLK68_RS05460	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HLK68_RS05470	ENOG4107FGU	50S ribosomal protein L33
HLK68_RS05475	ENOG410683Z	Preprotein translocase SecE subunit
HLK68_RS05480	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HLK68_RS05485	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HLK68_RS05490	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HLK68_RS05495	ENOG4108VZM	50s ribosomal protein L10
HLK68_RS05500	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HLK68_RS05505	ENOG4107Y49	methyltransferase
HLK68_RS05510	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HLK68_RS05515	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HLK68_RS05520	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HLK68_RS05525	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HLK68_RS05535	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HLK68_RS05545	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HLK68_RS05550	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HLK68_RS05555	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HLK68_RS05560	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLK68_RS05565	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HLK68_RS05570	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HLK68_RS05575	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HLK68_RS05580	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HLK68_RS05585	ENOG41082SA	50s ribosomal protein l29
HLK68_RS05595	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HLK68_RS05605	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HLK68_RS05610	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HLK68_RS05615	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HLK68_RS05625	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HLK68_RS05630	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HLK68_RS05635	ENOG4105VPB	50S ribosomal protein L30
HLK68_RS05645	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HLK68_RS05650	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HLK68_RS05655	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HLK68_RS05665	ENOG41067V7	50S ribosomal protein L36
HLK68_RS05670	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HLK68_RS05675	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HLK68_RS05680	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HLK68_RS05690	ENOG4105C8B	TIGR00159 family
HLK68_RS05700	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HLK68_RS05705	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HLK68_RS05710	ENOG41067TZ	transcriptional regulator, MarR family
HLK68_RS05735	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HLK68_RS05750	ENOG4105EJV	Membrane
HLK68_RS05760	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HLK68_RS05775	ENOG4105CPF	Cell wall formation (By similarity)
HLK68_RS05780	ENOG4108X4Q	Hydrolase
HLK68_RS05785	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HLK68_RS05795	ENOG4105CEV	competence damage-inducible protein
HLK68_RS05805	ENOG4105CP7	Triose-phosphate isomerase
HLK68_RS05815	ENOG4105CN5	Metallo-Beta-Lactamase
HLK68_RS05820	ENOG4106AKJ	
HLK68_RS05855	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HLK68_RS05860	ENOG4105F9F	transposase
HLK68_RS05870	ENOG4105N67	Proton-coupled thiamine transporter YuaJ
HLK68_RS05875	ENOG4105VEQ	Cold shock protein
HLK68_RS05905	ENOG4108X4Q	Hydrolase
HLK68_RS05920	ENOG4105C5Y	PTS System
HLK68_RS05930	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HLK68_RS05935	ENOG4105CJW	magnesium transporter
HLK68_RS05940	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HLK68_RS05945	ENOG4105GR3	Histidine kinase
HLK68_RS05965	ENOG41085KW	ppic-type peptidyL-prolyl cis-trans isomerase
HLK68_RS05970	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HLK68_RS05980	ENOG4105DZ1	carboxypeptidase
HLK68_RS05990	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HLK68_RS06010	ENOG4105DU0	nucleoside hydrolase
HLK68_RS06025	ENOG4105ST3	Transcriptional regulator
HLK68_RS06030	ENOG4108RCM	Nitroreductase
HLK68_RS06055	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HLK68_RS06070	ENOG4105F44	Two component transcriptional regulator, winged helix family
HLK68_RS06075	ENOG4106F60	Histidine kinase
HLK68_RS06080	ENOG4108RAC	Rubrerythrin
HLK68_RS06105	ENOG41076HS	cation diffusion facilitator family transporter
HLK68_RS06115	ENOG4105E66	phosphoriboisomerase A
HLK68_RS06125	ENOG4106KNT	transcriptional regulator
HLK68_RS06150	ENOG4105CZV	ABC transporter
HLK68_RS06155	ENOG4105ZMH	deoxynucleoside kinase
HLK68_RS06160	ENOG4105EKQ	RNA-directed DNA polymerase
HLK68_RS06180	ENOG4105VMP	Transcriptional regulator
HLK68_RS06190	ENOG4105K63	Thioredoxin
HLK68_RS06215	ENOG41067QW	Transcriptional regulator
HLK68_RS06225	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HLK68_RS06240	ENOG4105CPC	Aldo Keto reductase
HLK68_RS06250	ENOG4105F44	Two component transcriptional regulator, winged helix family
HLK68_RS06255	ENOG4105GR3	Histidine kinase
HLK68_RS06265	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HLK68_RS06275	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HLK68_RS06285	ENOG41076CZ	activating enzyme
HLK68_RS06290	ENOG4105G0K	glycine radical enzyme YjjI family
HLK68_RS06300	ENOG4105C8J	)-transporter
HLK68_RS06335	ENOG4105CE4	GlcNAc 6-P deacetylase
HLK68_RS06355	ENOG4106N3A	copper homeostasis protein cutc
HLK68_RS06370	ENOG4105II7	pyrroline-5-carboxylate reductase
HLK68_RS06375	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HLK68_RS06380	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
HLK68_RS06385	ENOG4105C02	permease
HLK68_RS06395	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HLK68_RS06405	ENOG4108UB7	
HLK68_RS06415	ENOG4108QCI	YvbH-like oligomerisation region
HLK68_RS06435	ENOG4105EA8	2-Nitropropane dioxygenase
HLK68_RS06440	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HLK68_RS06445	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HLK68_RS06450	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HLK68_RS06455	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HLK68_RS06465	ENOG4105EA8	2-Nitropropane dioxygenase
HLK68_RS06470	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HLK68_RS06475	ENOG4105CHR	reductase
HLK68_RS06480	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HLK68_RS06495	ENOG4108W76	histidinol phosphate phosphatase hisj family
HLK68_RS06500	ENOG4105FAA	peptidase M23
HLK68_RS06570	ENOG4105K8N	protein family UPF0079, ATPase
HLK68_RS06575	ENOG41072GX	Peptidase M22 Glycoprotease
HLK68_RS06585	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HLK68_RS06595	ENOG4105C5H	ABC transporter
HLK68_RS06600	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
HLK68_RS06610	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HLK68_RS06620	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HLK68_RS06625	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HLK68_RS06630	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HLK68_RS06635	ENOG4105WG9	Conserved Protein
HLK68_RS06640	ENOG4108SGW	outer membrane lipoprotein-sorting protein-like protein
HLK68_RS06650	ENOG4108STX	response regulator
HLK68_RS06655	ENOG4105BZU	Histidine kinase
HLK68_RS06660	ENOG4105CHM	Aminotransferase
HLK68_RS06665	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
HLK68_RS06675	ENOG410691R	Modulates RecA activity (By similarity)
HLK68_RS06680	ENOG4105FDP	GntR family transcriptional regulator
HLK68_RS06695	ENOG4105CG3	alpha amylase, catalytic region
HLK68_RS06700	ENOG4105DR5	peptidase
HLK68_RS06705	ENOG4108JU6	CBS domain protein
HLK68_RS06715	ENOG4105CKK	Glycosyl transferase, family 2
HLK68_RS06725	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HLK68_RS06730	ENOG4105CBD	Diacylglycerol kinase
HLK68_RS06735	ENOG4105IEH	endo-beta-N-acetylglucosaminidase
HLK68_RS06760	ENOG4105F9F	transposase
HLK68_RS06775	ENOG4105TWJ	Domain of unknown function (DUF1919)
HLK68_RS06780	ENOG4105CND	Glycosyl transferase, family 2
HLK68_RS06790	ENOG4105CMR	udp-glucose 4-epimerase
HLK68_RS06860	ENOG4105IEH	endo-beta-N-acetylglucosaminidase
HLK68_RS06875	ENOG4105CX6	glutaminyL-tRNA synthetase
HLK68_RS06880	ENOG4105C4R	Atp-dependent dna helicase
HLK68_RS06885	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HLK68_RS06900	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HLK68_RS06910	ENOG41086DT	Membrane protein of unknown function
HLK68_RS06920	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HLK68_RS06925	ENOG4107XGZ	Hydrolase
HLK68_RS06930	ENOG4105C3M	thioredoxin reductase
HLK68_RS06950	ENOG4105CHW	UPF0052 protein
HLK68_RS06955	ENOG4105CIE	May be required for sporulation (By similarity)
HLK68_RS06960	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HLK68_RS06970	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HLK68_RS06975	ENOG4105C02	permease
HLK68_RS06980	ENOG4105FEU	K -dependent Na -Ca exchanger
HLK68_RS06990	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HLK68_RS06995	ENOG4105PNM	synthesis protein
HLK68_RS07000	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HLK68_RS07005	ENOG4105EWK	phytoene
HLK68_RS07020	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HLK68_RS07035	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
HLK68_RS07045	ENOG4105D2X	ABC transporter substrate-binding protein
HLK68_RS07050	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HLK68_RS07055	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HLK68_RS07060	ENOG4105DRS	transport system, permease
HLK68_RS07065	ENOG4108IJG	ABC transporter substrate-binding protein
HLK68_RS07070	ENOG4105SFS	phosphoesterase RecJ domain protein
HLK68_RS07075	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HLK68_RS07080	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HLK68_RS07090	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HLK68_RS07095	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
HLK68_RS07105	ENOG4105WZW	rhodanese family
HLK68_RS07125	ENOG4108UT2	hemolysin iii
HLK68_RS07135	ENOG4105CEM	UPF0597 protein
HLK68_RS07140	ENOG4105DZ6	Band 7 protein
HLK68_RS07155	ENOG4105C02	permease
HLK68_RS07170	ENOG4105C59	p-type ATPase
HLK68_RS07180	ENOG4105BZU	Histidine kinase
HLK68_RS07190	ENOG4108RVA	ribokinase
HLK68_RS07200	ENOG4105DND	Transcriptional regulator
HLK68_RS07205	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HLK68_RS07220	ENOG4105EWK	phytoene
HLK68_RS07230	ENOG4107QMU	Mate efflux family protein
HLK68_RS07240	ENOG4105BZU	Histidine kinase
HLK68_RS07260	ENOG410681U	heavy metal transport detoxification protein
HLK68_RS07275	ENOG4105C19	ABC transporter
HLK68_RS07290	ENOG4105CJ1	ABC, transporter
HLK68_RS07310	ENOG4105BZU	Histidine kinase
HLK68_RS07315	ENOG4105CID	antiterminator
HLK68_RS07325	ENOG4105C5Y	PTS System
HLK68_RS07330	ENOG4105CS2	ec 3.2.1.21
HLK68_RS07355	ENOG4107R73	Mate efflux family protein
HLK68_RS07360	ENOG4105VEQ	Cold shock protein
HLK68_RS07365	ENOG4107Y2X	deaminase
HLK68_RS07385	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HLK68_RS07390	ENOG41083WA	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
HLK68_RS07410	ENOG4105DNP	FAD linked oxidase domain protein
HLK68_RS07420	ENOG4105MAX	Superoxide reductase
HLK68_RS07435	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HLK68_RS07450	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
HLK68_RS07460	ENOG4105DQ5	transport system permease protein
HLK68_RS07465	ENOG4105E0A	ABC, transporter
HLK68_RS07490	ENOG4108R6W	Transcriptional regulator, ARAC family
HLK68_RS07510	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HLK68_RS07530	ENOG4108YYD	acetyltransferase
HLK68_RS07545	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HLK68_RS07565	ENOG4107EFR	Flavocytochrome c
HLK68_RS07580	ENOG4105D9P	serine threonine protein kinase
HLK68_RS07590	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HLK68_RS07595	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HLK68_RS07600	ENOG4108YZT	Adenosylcobinamide kinase
HLK68_RS07605	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HLK68_RS07625	ENOG4107QZB	decarboxylase
HLK68_RS07645	ENOG4105EHG	Permease protein
HLK68_RS07650	ENOG4105E0A	ABC, transporter
HLK68_RS07675	ENOG4105KT7	mgtC SapB transporter
HLK68_RS07685	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HLK68_RS07690	ENOG4105CFI	type iii restriction protein res subunit
HLK68_RS07695	ENOG4105M6F	mutator MutT protein
HLK68_RS07740	ENOG4105D0C	transport protein
HLK68_RS07745	ENOG4107QIV	Cytochrome c biogenesis protein
HLK68_RS07760	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
HLK68_RS07765	ENOG4105DQ5	transport system permease protein
HLK68_RS07770	ENOG4105EHG	Permease protein
HLK68_RS07775	ENOG4105E0A	ABC, transporter
HLK68_RS07780	ENOG4107Y80	Major Facilitator superfamily
HLK68_RS07795	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HLK68_RS07800	ENOG4105CFH	Aspartokinase
HLK68_RS07805	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HLK68_RS07810	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HLK68_RS07815	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HLK68_RS07820	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HLK68_RS07825	ENOG4105VUF	Transcriptional regulator
HLK68_RS07835	ENOG4105C2X	Arabinose 5-phosphate isomerase
HLK68_RS07845	ENOG4105CS2	ec 3.2.1.21
HLK68_RS07865	ENOG4105HMI	Membrane
HLK68_RS07875	ENOG4105BZU	Histidine kinase
HLK68_RS07895	ENOG4105W5Q	DNA repair protein (RadC
HLK68_RS07900	ENOG410695V	Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP (By similarity)
HLK68_RS07925	ENOG410826E	Dna repair protein radc
HLK68_RS07955	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HLK68_RS07980	ENOG4105W5Q	DNA repair protein (RadC
HLK68_RS08065	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
HLK68_RS08075	ENOG4108F3G	Type I restriction-modification system, R subunit
HLK68_RS08080	ENOG4105W5Q	DNA repair protein (RadC
HLK68_RS08110	ENOG4105DZR	Type I site-specific deoxyribonuclease
HLK68_RS08125	ENOG4105W5Q	DNA repair protein (RadC
HLK68_RS08215	ENOG4105C5Q	Transcriptional regulator
HLK68_RS08230	ENOG4105CBC	glutamate synthase
HLK68_RS08250	ENOG4105F6S	Spore photoproduct lyase
HLK68_RS08260	ENOG4108KGH	TRANSCRIPTIONal
HLK68_RS08265	ENOG4105CFP	Peptidase U32
HLK68_RS08270	ENOG4108QG2	Membrane
HLK68_RS08275	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HLK68_RS08285	ENOG4105YWU	small acid-soluble spore protein
HLK68_RS08290	ENOG4105YWU	small acid-soluble spore protein
HLK68_RS08295	ENOG4105YWU	small acid-soluble spore protein
HLK68_RS08300	ENOG41080E8	Transcriptional regulator, Spx MgsR family
HLK68_RS08310	ENOG4105EVI	UPF0374 protein
HLK68_RS08405	ENOG4105CG3	alpha amylase, catalytic region
HLK68_RS08420	ENOG4105F9F	transposase
HLK68_RS08430	ENOG4105EG2	ABC transporter, permease
HLK68_RS08435	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HLK68_RS08445	ENOG41067QW	Transcriptional regulator
HLK68_RS08525	ENOG4107QJE	Chromosome Partitioning Protein
HLK68_RS08540	ENOG4108UW5	maltose o-acetyltransferase
HLK68_RS08560	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HLK68_RS08575	ENOG41067QW	Transcriptional regulator
HLK68_RS08580	ENOG41069JR	
HLK68_RS08585	ENOG4105DA5	(ABC) transporter
HLK68_RS08600	ENOG4105ETE	Transcriptional regulator (LacI family
HLK68_RS08605	ENOG4105C5Y	PTS System
HLK68_RS08645	ENOG4108R6W	Transcriptional regulator, ARAC family
HLK68_RS08655	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HLK68_RS08660	ENOG4105DRS	transport system, permease
HLK68_RS08680	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HLK68_RS08695	ENOG4105CNT	hydrolase family 2
HLK68_RS08700	ENOG4105CNT	hydrolase family 2
HLK68_RS08705	ENOG4105KRI	phosphocarrier protein (HPr
HLK68_RS08720	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HLK68_RS08730	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HLK68_RS08735	ENOG4105CQ4	Transcriptional regulator
HLK68_RS08740	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HLK68_RS08745	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
HLK68_RS08750	ENOG4105CMR	udp-glucose 4-epimerase
HLK68_RS08765	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HLK68_RS08805	ENOG4107RAQ	aminopeptidase
HLK68_RS08825	ENOG4105EAM	Na Pi-cotransporter
HLK68_RS08830	ENOG4105C3K	feS assembly ATPase SufC
HLK68_RS08835	ENOG4105JRK	feS assembly protein SufD
HLK68_RS08840	ENOG4105C9B	Cysteine desulfurase
HLK68_RS08845	ENOG4108UNV	SUF system FeS assembly protein, NifU family
HLK68_RS08850	ENOG4105DIW	FeS assembly protein SUFB
HLK68_RS08860	ENOG41080XQ	Signal transduction protein with cbs domains
HLK68_RS08865	ENOG4105KZD	Domain of unknown function (DUF1805)
HLK68_RS08875	ENOG4105C19	ABC transporter
HLK68_RS08880	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HLK68_RS08895	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HLK68_RS08900	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HLK68_RS08925	ENOG4108P49	AntiSigma factor
HLK68_RS08930	ENOG4105JVQ	RNA Polymerase
HLK68_RS08935	ENOG4108P49	AntiSigma factor
HLK68_RS08945	ENOG4105C4X	radical SAM domain protein
HLK68_RS08960	ENOG4105CFI	type iii restriction protein res subunit
HLK68_RS08985	ENOG4105DB7	PHP domain protein
HLK68_RS08995	ENOG4108RAC	Rubrerythrin
HLK68_RS09010	ENOG4108ETY	sodium dicarboxylate symporter
HLK68_RS09020	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HLK68_RS09050	ENOG4108NRW	Phospholipase, patatin family
HLK68_RS09055	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HLK68_RS09060	ENOG4107YDN	peptide deformylase
HLK68_RS09065	ENOG4108KYE	ABC-2 type transporter
HLK68_RS09075	ENOG4105CJ1	ABC, transporter
HLK68_RS09080	ENOG4105WH1	Two component transcriptional regulator luxr family
HLK68_RS09085	ENOG4105BZU	Histidine kinase
HLK68_RS09110	ENOG4105C4R	Atp-dependent dna helicase
HLK68_RS09130	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HLK68_RS09135	ENOG4108UMI	ABC transporter, permease
HLK68_RS09140	ENOG4105D01	(LipO)protein
HLK68_RS09160	ENOG4105D0C	transport protein
HLK68_RS09165	ENOG4105NBF	ammecr1 domain protein
HLK68_RS09190	ENOG4108QBV	Monogalactosyldiacylglycerol synthase
HLK68_RS09195	ENOG4105CH2	amidohydrolase
HLK68_RS09215	ENOG4105C5Y	PTS System
HLK68_RS09235	ENOG4105CAH	Chromate
HLK68_RS09240	ENOG4105F9F	transposase
HLK68_RS09245	ENOG4105C1J	atp-dependent rna helicase
HLK68_RS09250	ENOG4105BZU	Histidine kinase
HLK68_RS09255	ENOG4105C1J	atp-dependent rna helicase
HLK68_RS09260	ENOG4108VW9	Membrane
HLK68_RS09265	ENOG4108IUM	Glycogen debranching enzyme
HLK68_RS09275	ENOG4105D4P	Coproporphyrinogen iii oxidase
HLK68_RS09280	ENOG4105EQI	Metal Dependent Phosphohydrolase
HLK68_RS09285	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HLK68_RS09305	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
HLK68_RS09320	ENOG4108Z6M	essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA B D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin cytochrome c6- ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn
HLK68_RS09345	ENOG4107QIZ	NADH dehydrogenase
HLK68_RS09350	ENOG4107QHI	-hydrogenase
HLK68_RS09360	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HLK68_RS09365	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HLK68_RS09370	ENOG4105EUJ	GTP cyclohydrolase i
HLK68_RS09375	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HLK68_RS09380	ENOG4105D49	3-dehydroquinate synthase
HLK68_RS09385	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HLK68_RS09390	ENOG41068YB	TPR repeat-containing protein
HLK68_RS09400	ENOG4108JYZ	YitT family
HLK68_RS09410	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HLK68_RS09425	ENOG4105CSM	endonuclease III
HLK68_RS09430	ENOG4105BZ4	penicillin-binding protein
HLK68_RS09450	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HLK68_RS09460	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HLK68_RS09465	ENOG4105D48	metallophosphoesterase
HLK68_RS09470	ENOG4105MCT	stage V sporulation protein S
HLK68_RS09475	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HLK68_RS09495	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HLK68_RS09500	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HLK68_RS09505	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HLK68_RS09515	ENOG4105VPS	UPF0291 protein
HLK68_RS09535	ENOG4105VXM	UPF0154 protein
HLK68_RS09545	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HLK68_RS09550	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HLK68_RS09570	ENOG4105C9A	Phoh family
HLK68_RS09575	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HLK68_RS09580	ENOG4107YR5	Diacylglycerol kinase
HLK68_RS09585	ENOG4105KG3	cytidine deaminase
HLK68_RS09590	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HLK68_RS09600	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
HLK68_RS09605	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HLK68_RS09610	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HLK68_RS09615	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HLK68_RS09625	ENOG4105EGD	dinuclear metal center protein, YbgI family
HLK68_RS09630	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HLK68_RS09635	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HLK68_RS09640	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HLK68_RS09645	ENOG4105ETE	Transcriptional regulator (LacI family
HLK68_RS09655	ENOG4105ID8	Transcriptional regulator, ARAC family
HLK68_RS09670	ENOG4105DUM	transcriptional regulator, lysR family
HLK68_RS09695	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HLK68_RS09700	ENOG4105C0A	alcohol dehydrogenase
HLK68_RS09710	ENOG4107WD8	ABC transporter, permease
HLK68_RS09715	ENOG4105YWU	small acid-soluble spore protein
HLK68_RS09735	ENOG4108RWN	rrna methyltransferase
HLK68_RS09740	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HLK68_RS09745	ENOG4105CHV	Transcription elongation factor NusA
HLK68_RS09750	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
HLK68_RS09755	ENOG4105VHM	ribosomal protein
HLK68_RS09760	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HLK68_RS09765	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HLK68_RS09775	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HLK68_RS09780	ENOG4105PFC	Transcriptional regulator
HLK68_RS09795	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HLK68_RS09805	ENOG4105M59	Phosphodiesterase, mj0936 family
HLK68_RS09835	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HLK68_RS09845	ENOG4105DUM	transcriptional regulator, lysR family
HLK68_RS09870	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HLK68_RS09875	ENOG4107ZYR	domain protein
HLK68_RS09915	ENOG4105PTM	secreted protein
HLK68_RS09955	ENOG4108X4Q	Hydrolase
HLK68_RS09965	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HLK68_RS10000	ENOG4105CNI	cell division protein FtsW
HLK68_RS10020	ENOG4105WUC	UPF0298 protein
HLK68_RS10025	ENOG4105K5M	30s ribosomal protein S16
HLK68_RS10030	ENOG4105VB6	UPF0109 protein
HLK68_RS10065	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HLK68_RS10070	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HLK68_RS10075	ENOG4107PPM	cobalt chelatase
HLK68_RS10090	ENOG4105D52	delta-aminolevulinic acid dehydratase
HLK68_RS10095	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HLK68_RS10100	ENOG4105EAB	amino acid AbC transporter
HLK68_RS10105	ENOG4105E5Q	amino acid AbC transporter
HLK68_RS10110	ENOG4105CDA	abc transporter atp-binding protein
HLK68_RS10120	ENOG4105E70	isomerase
HLK68_RS10125	ENOG4105D2N	Aldolase
HLK68_RS10130	ENOG4105C2F	Histidine kinase
HLK68_RS10135	ENOG4105EQD	regulatoR
HLK68_RS10190	ENOG4105CT8	Phosphorylase
HLK68_RS10215	ENOG4105K56	Transcriptional regulator
HLK68_RS10220	ENOG4108V06	Glutathione peroxidase
HLK68_RS10250	ENOG4105BZ1	(ABC) transporter
HLK68_RS10270	ENOG4105J7I	hydrolase
HLK68_RS10320	ENOG4107QW3	Sucrose phosphorylase
HLK68_RS10335	ENOG4105BZW	Glycerate kinase
HLK68_RS10340	ENOG4107QQ0	gntp family
HLK68_RS10345	ENOG41087YS	Phage shock protein A
HLK68_RS10365	ENOG4106D6I	small acid-soluble spore protein
HLK68_RS10370	ENOG4108Z0R	Transferase
HLK68_RS10395	ENOG4105DB7	PHP domain protein
HLK68_RS10400	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HLK68_RS10405	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HLK68_RS10425	ENOG4105DFU	Cell wall formation (By similarity)
HLK68_RS10450	ENOG4105D1F	ATP-binding protein
HLK68_RS10455	ENOG4105CDE	UPF0348 protein
HLK68_RS10460	ENOG4105KNH	Nucleic acid-binding protein
HLK68_RS10465	ENOG41067VY	50S ribosomal protein L32
HLK68_RS10480	ENOG4108IUH	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HLK68_RS10485	ENOG4105C1J	atp-dependent rna helicase
HLK68_RS10490	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HLK68_RS10510	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HLK68_RS10520	ENOG4107RF6	penicillin-binding protein
HLK68_RS10535	ENOG4105DKQ	ROK family
HLK68_RS10540	ENOG4105C5X	domain protein
HLK68_RS10550	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HLK68_RS10610	ENOG4105DZ0	fad dependent oxidoreductase
HLK68_RS10615	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HLK68_RS10655	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HLK68_RS10665	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HLK68_RS10690	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HLK68_RS10695	ENOG4105DIB	Oligopeptide-binding protein
HLK68_RS10700	ENOG4105C5H	ABC transporter
HLK68_RS10715	ENOG4105DVT	helicase
HLK68_RS10720	ENOG41067TZ	transcriptional regulator, MarR family
HLK68_RS10725	ENOG4105BZ1	(ABC) transporter
HLK68_RS10730	ENOG4105BZ1	(ABC) transporter
HLK68_RS10735	ENOG4105D3Q	Sugar transferase
HLK68_RS10740	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HLK68_RS10750	ENOG4108YBP	pseudouridine synthase
HLK68_RS10790	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HLK68_RS10800	ENOG4105C2I	pirin domain protein
HLK68_RS10805	ENOG4105CMR	udp-glucose 4-epimerase
HLK68_RS10845	ENOG4107SC7	Inner membrane transporter yjeM
HLK68_RS10850	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HLK68_RS10855	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HLK68_RS10865	ENOG4108JJ9	ABC, transporter
HLK68_RS10870	ENOG4105BZ1	(ABC) transporter
HLK68_RS10875	ENOG4105VXR	cytoplasmic protein
HLK68_RS10880	ENOG4105WD1	Membrane
HLK68_RS10900	ENOG4105D5B	Sulfite reductase, subunit A
HLK68_RS10905	ENOG4107SHJ	sulfite reductase subunit b
HLK68_RS10910	ENOG410810Y	Sulfite reductase
HLK68_RS10915	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HLK68_RS10940	ENOG4107QW4	alcohol dehydrogenase
HLK68_RS10955	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLK68_RS10960	ENOG4105D1Q	UPF0246 protein
HLK68_RS11020	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HLK68_RS11035	ENOG4105C5H	ABC transporter
HLK68_RS11045	ENOG4108UW5	maltose o-acetyltransferase
HLK68_RS11060	ENOG4105VKD	bioY protein
HLK68_RS11085	ENOG4105C1J	atp-dependent rna helicase
HLK68_RS11095	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HLK68_RS11105	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HLK68_RS11110	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HLK68_RS11115	ENOG4105E0C	molybdate abc transporter
HLK68_RS11125	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HLK68_RS11145	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HLK68_RS11160	ENOG4105FE9	pseudouridine synthase
HLK68_RS11180	ENOG4108W15	Protein of unknown function (DUF1456)
HLK68_RS11190	ENOG4105E0M	Sulfatase
HLK68_RS11230	ENOG4108UW5	maltose o-acetyltransferase
HLK68_RS11250	ENOG4108UW5	maltose o-acetyltransferase
HLK68_RS11255	ENOG410667J	hydrolase
HLK68_RS11260	ENOG4105KHA	Glyoxalase Bleomycin resistance protein (Dioxygenase
HLK68_RS11265	ENOG4105C5W	Aldolase
HLK68_RS11280	ENOG4105HDK	L-asparaginase
HLK68_RS11300	ENOG4105BZ1	(ABC) transporter
HLK68_RS11305	ENOG4105D29	Helix-turn-helix type 11 domain protein
HLK68_RS11355	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HLK68_RS11360	ENOG4105BZU	Histidine kinase
HLK68_RS11375	ENOG4105D44	asparaginase
HLK68_RS11405	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HLK68_RS11415	ENOG4105E98	transcriptional regulator DeoR family
HLK68_RS11420	ENOG4105DE4	1-phosphofructokinase
HLK68_RS11425	ENOG4105DM4	PTS System
HLK68_RS11450	ENOG4107R4J	Chloride channel
HLK68_RS11455	ENOG4105CGK	Exodeoxyribonuclease III
HLK68_RS11460	ENOG4105US7	Histidine kinase
HLK68_RS11465	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HLK68_RS11485	ENOG41075D4	Aminoglycoside 6-adenylyltransferase
HLK68_RS11545	ENOG41082YX	Transcriptional regulator, arsr family
HLK68_RS11555	ENOG4105UQX	Mate efflux family protein
HLK68_RS11580	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HLK68_RS11585	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HLK68_RS11590	ENOG4105EUJ	GTP cyclohydrolase i
HLK68_RS11595	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HLK68_RS11600	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HLK68_RS11605	ENOG4105CTD	carboxy-peptidase
HLK68_RS11615	ENOG4108HCJ	Hydrolase
HLK68_RS11630	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HLK68_RS11655	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HLK68_RS11670	ENOG4105DIB	Oligopeptide-binding protein
HLK68_RS11675	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HLK68_RS11680	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HLK68_RS11685	ENOG4105C3U	ABC transporter
HLK68_RS11690	ENOG4108JQ7	(ABC) transporter
HLK68_RS11720	ENOG4105M7K	Involved in the transcription termination process (By similarity)
HLK68_RS11725	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HLK68_RS11730	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HLK68_RS11735	ENOG4105CTB	Polyprenyl synthetase
HLK68_RS11740	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HLK68_RS11745	ENOG4105DX0	Hemolysin A
HLK68_RS11750	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HLK68_RS11755	ENOG4105S1Z	Stage IV sporulation protein B
HLK68_RS11760	ENOG4107QQR	Sporulation
HLK68_RS11765	ENOG4105F32	YngK protein
HLK68_RS11775	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HLK68_RS11790	ENOG4105I3K	Ferric uptake regulator, Fur family
HLK68_RS11795	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HLK68_RS11805	ENOG4108Z3G	3H domain protein
HLK68_RS11815	ENOG4105DD7	kinase (PfkB family
HLK68_RS11825	ENOG4105CI1	PTS System
HLK68_RS11890	ENOG4108Z66	YbaK ebsC protein
HLK68_RS11895	ENOG410696E	Membrane
HLK68_RS11905	ENOG4107STQ	Multicopper oxidase
HLK68_RS11910	ENOG41082IR	Excinuclease ABC C subunit domain protein
HLK68_RS11920	ENOG4105QEK	Transcriptional regulator
HLK68_RS11930	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HLK68_RS11935	ENOG4105DRS	transport system, permease
HLK68_RS11940	ENOG4105UQX	Mate efflux family protein
HLK68_RS11950	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HLK68_RS11965	ENOG4105CGH	5'-nucleotidase
HLK68_RS11990	ENOG4105DFD	Na H antiporter
HLK68_RS11995	ENOG4105VEQ	Cold shock protein
HLK68_RS12035	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HLK68_RS12050	ENOG4105EPR	degv family
HLK68_RS12055	ENOG4107XJU	UPF0178 protein
HLK68_RS12060	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HLK68_RS12065	ENOG4108QEG	Membrane
HLK68_RS12080	ENOG4105W7A	Protein of unknown function (DUF503)
HLK68_RS12085	ENOG4105C02	permease
HLK68_RS12095	ENOG4105UQX	Mate efflux family protein
HLK68_RS12100	ENOG4108ZB6	transcriptional regulator AsnC family
HLK68_RS12105	ENOG4105CHM	Aminotransferase
HLK68_RS12120	ENOG4105EYW	Ion transport protein
HLK68_RS12130	ENOG41090T1	Membrane
HLK68_RS12135	ENOG41082BM	Transcriptional regulator, arsr family
HLK68_RS12150	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HLK68_RS12185	ENOG4105C31	Tryptophanyl-tRNA synthetase
HLK68_RS12200	ENOG4107SDT	Homocitrate synthase
HLK68_RS12210	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HLK68_RS12215	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HLK68_RS12250	ENOG4108RG5	PTS system N-acetylgalactosamine-specific transporter subunit IIB
HLK68_RS12255	ENOG4105ETZ	PTS System
HLK68_RS12260	ENOG4105F3R	pts system mannose fructose sorbose family iid
HLK68_RS12275	ENOG4105WEF	catalase
HLK68_RS12280	ENOG4105WEF	catalase
HLK68_RS12310	ENOG4105BZ1	(ABC) transporter
HLK68_RS12320	ENOG4105BZU	Histidine kinase
HLK68_RS12325	ENOG4105C7Z	Conserved Protein
HLK68_RS12335	ENOG4108QY0	Membrane
HLK68_RS12375	ENOG4105CFI	type iii restriction protein res subunit
HLK68_RS12390	ENOG4105ENX	hydrolase
HLK68_RS12415	ENOG4105CPC	Aldo Keto reductase
HLK68_RS12450	ENOG4105C5I	Dehydrogenase
HLK68_RS12460	ENOG4108MRH	transcriptional regulatory protein
HLK68_RS12470	ENOG4105CPC	Aldo Keto reductase
HLK68_RS12490	ENOG4105CN9	Peptidase m42 family protein
HLK68_RS12495	ENOG4105FQP	Beta-lactamase
HLK68_RS12520	ENOG4107QI1	Mate efflux family protein
HLK68_RS12545	ENOG410667J	hydrolase
HLK68_RS12565	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HLK68_RS12570	ENOG4105CAQ	asparagine synthetase
HLK68_RS12585	ENOG4107RB3	L-asparaginase
HLK68_RS12595	ENOG4108JJB	ABC transporter
HLK68_RS12600	ENOG4105C7J	ABC transporter, permease
HLK68_RS12635	ENOG4105C8J	)-transporter
HLK68_RS12655	ENOG4105ED2	Beta-lactamase
HLK68_RS12665	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HLK68_RS12670	ENOG4105CYW	agmatinase
HLK68_RS12680	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
HLK68_RS12685	ENOG4105CXN	decarboxylase
HLK68_RS12715	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HLK68_RS12735	ENOG4108IUM	Glycogen debranching enzyme
HLK68_RS12745	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HLK68_RS12750	ENOG4105UQX	Mate efflux family protein
HLK68_RS12755	ENOG4105CHR	reductase
HLK68_RS12765	ENOG4108RTU	Aldolase
HLK68_RS12770	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
HLK68_RS12785	ENOG4105CTX	dehydratase
HLK68_RS12790	ENOG4107QZW	Altronate oxidoreductase
HLK68_RS12795	ENOG4105D2H	Uronic isomerase
HLK68_RS12810	ENOG4105F5H	Glycosyl Hydrolase Family 88
HLK68_RS12815	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HLK68_RS12820	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HLK68_RS12855	ENOG4108V7D	UPF0397 protein
HLK68_RS12860	ENOG4105CBX	hi0933 family
HLK68_RS12880	ENOG4108HM4	ABC transporter
HLK68_RS12885	ENOG4105D38	putrescine abc transporter
HLK68_RS12890	ENOG4105F38	ABC transporter, permease
HLK68_RS12895	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HLK68_RS12910	ENOG4105CI3	gtp-binding protein typa
HLK68_RS12915	ENOG4105TQK	DNA polymerase iii, delta' subunit
HLK68_RS12920	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HLK68_RS12925	ENOG4105KQC	Competence protein
HLK68_RS12935	ENOG4105DXX	methyltransferase
HLK68_RS12945	ENOG4108WF2	Metal Dependent Phosphohydrolase
HLK68_RS12950	ENOG410812S	Rna-binding protein
HLK68_RS12960	ENOG4105CQW	ribosome biogenesis GTPase YqeH
HLK68_RS12965	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
HLK68_RS12970	ENOG4105DMD	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HLK68_RS12975	ENOG4108DWA	Nad synthetase
HLK68_RS12980	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HLK68_RS12990	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HLK68_RS12995	ENOG4105DBI	uridine monophosphokinase
HLK68_RS13000	ENOG4105CFP	Peptidase U32
HLK68_RS13005	ENOG4105XYU	peptidase (U32 family)
HLK68_RS13020	ENOG4105VPH	UPF0473 protein
HLK68_RS13025	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HLK68_RS13035	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HLK68_RS13045	ENOG4105C7H	Helicase, RecD TraA family
HLK68_RS13050	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HLK68_RS13060	ENOG4105UIB	(ABC) transporter
HLK68_RS13065	ENOG4108JQ9	ABC transporter
HLK68_RS13070	ENOG4107TFB	basic membrane
HLK68_RS13075	ENOG4105DIH	basic membrane
HLK68_RS13085	ENOG4105CNU	cell division protein FtsK
HLK68_RS13095	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HLK68_RS13105	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HLK68_RS13110	ENOG4105E35	Dipicolinate synthase subunit A
HLK68_RS13120	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HLK68_RS13125	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HLK68_RS13130	ENOG4105DTN	riboflavin biosynthesis protein ribF
HLK68_RS13135	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HLK68_RS13140	ENOG4105CSA	Coproporphyrinogen iii oxidase
HLK68_RS13150	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HLK68_RS13175	ENOG4105CIN	aminoacyl-histidine dipeptidase
HLK68_RS13190	ENOG4105DAP	Nicotinate phosphoribosyltransferase
HLK68_RS13195	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HLK68_RS13235	ENOG4105F9F	transposase
HLK68_RS13240	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HLK68_RS13245	ENOG4105WZW	rhodanese family
HLK68_RS13250	ENOG4105KTH	gatB Yqey
HLK68_RS13270	ENOG4105DQ6	Transposase
HLK68_RS13275	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HLK68_RS13280	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HLK68_RS13285	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HLK68_RS13290	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HLK68_RS13295	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HLK68_RS13300	ENOG4105CFG	Acts as a chaperone (By similarity)
HLK68_RS13305	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLK68_RS13310	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HLK68_RS13315	ENOG4105K63	Thioredoxin
HLK68_RS13325	ENOG4108HW4	amino acid AbC transporter
HLK68_RS13330	ENOG4107RP9	extracellular solute-binding protein, family 3
HLK68_RS13335	ENOG4105C98	muts2 protein
HLK68_RS13345	ENOG4107ZXI	Rhomboid family
HLK68_RS13350	ENOG4105C34	Pseudouridine synthase
HLK68_RS13360	ENOG4107YWA	deoxycytidylate deaminase
HLK68_RS13375	ENOG4105K7K	Transcriptional regulator
HLK68_RS13380	ENOG4105CE4	GlcNAc 6-P deacetylase
HLK68_RS13385	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HLK68_RS13395	ENOG4105DBK	s4 domain protein
HLK68_RS13400	ENOG41067XK	integral membrane protein
HLK68_RS13405	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
HLK68_RS13410	ENOG4105DFA	alanine racemase domain protein
HLK68_RS13415	ENOG4105WR5	sporulation protein, YlmC YmxH family
HLK68_RS13425	ENOG4105DAV	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HLK68_RS13440	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HLK68_RS13445	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HLK68_RS13455	ENOG4105D4A	Cell wall formation (By similarity)
HLK68_RS13460	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HLK68_RS13465	ENOG4105CNI	cell division protein FtsW
HLK68_RS13470	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HLK68_RS13480	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HLK68_RS13485	ENOG4105CJN	penicillin-binding protein
HLK68_RS13490	ENOG4105CJN	penicillin-binding protein
HLK68_RS13500	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HLK68_RS13505	ENOG4108V6E	Cell division protein mraZ
HLK68_RS13510	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HLK68_RS13515	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HLK68_RS13520	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HLK68_RS13525	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HLK68_RS13575	ENOG4105CEE	C4-dicarboxylate transporter
HLK68_RS13585	ENOG4105ENA	helicase
HLK68_RS13605	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HLK68_RS13610	ENOG4105EE0	oxidoreductase
HLK68_RS13630	ENOG4107RWR	Sodium hydrogen exchanger
HLK68_RS13650	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HLK68_RS13665	ENOG4105E5G	Alpha beta hydrolase fold
HLK68_RS13675	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HLK68_RS13685	ENOG4105DZP	Membrane-associated zinc metalloprotease
HLK68_RS13695	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HLK68_RS13715	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HLK68_RS13720	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HLK68_RS13725	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HLK68_RS13735	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HLK68_RS13740	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HLK68_RS13755	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HLK68_RS13765	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
HLK68_RS13775	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HLK68_RS13780	ENOG4107VMI	polysaccharide deacetylase
HLK68_RS13785	ENOG4105C79	DNA protecting protein DprA
HLK68_RS13805	ENOG4105C3F	Signal peptidase i
HLK68_RS13810	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HLK68_RS13820	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HLK68_RS13825	ENOG4108R3D	Electron transport complex
HLK68_RS13835	ENOG4105DGN	Electron transport complex
HLK68_RS13840	ENOG4105DZB	Electron transport complex
HLK68_RS13850	ENOG4105D6A	Electron transport complex
HLK68_RS13855	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
HLK68_RS13885	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HLK68_RS13890	ENOG4106H78	methyltransferase
HLK68_RS13910	ENOG4105G6Z	alkaline phosphatase
HLK68_RS13920	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
HLK68_RS13925	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HLK68_RS13930	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HLK68_RS13955	ENOG4105C26	Dehydrogenase
HLK68_RS14010	ENOG4105BZG	amino acid carrier protein
HLK68_RS14055	ENOG41076QQ	Glycosyl transferase, family 2
HLK68_RS14100	ENOG4105JVQ	RNA Polymerase
HLK68_RS14125	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
HLK68_RS14140	ENOG4105EYH	Exonuclease
HLK68_RS14145	ENOG4107RFY	SbcCD D subunit
HLK68_RS14150	ENOG4105CMD	Transcriptional regulator, GntR family
HLK68_RS14185	ENOG4108IXY	short-chain dehydrogenase reductase
HLK68_RS14200	ENOG4105CB5	ATP-dependent DNA helicase recG
HLK68_RS14205	ENOG4105DP4	dak2 domain fusion protein ylov
HLK68_RS14210	ENOG4108ZAA	Alkaline-shock protein
HLK68_RS14215	ENOG4105VB9	50S ribosomal protein l28
HLK68_RS14240	ENOG4105FJ0	thiamine
HLK68_RS14245	ENOG4105DJV	ribulose-phosphate 3-epimerase
HLK68_RS14250	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HLK68_RS14255	ENOG4105D9P	serine threonine protein kinase
HLK68_RS14260	ENOG4108ZF3	Phosphatase
HLK68_RS14270	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HLK68_RS14275	ENOG4107AYK	membrAne
HLK68_RS14280	ENOG4107AYK	membrAne
HLK68_RS14285	ENOG4105QNR	S1 RNA binding domain protein
HLK68_RS14300	ENOG4105CNW	domain protein
HLK68_RS14305	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HLK68_RS14315	ENOG4105C25	Primosomal protein n'
HLK68_RS14320	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HLK68_RS14325	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HLK68_RS14335	ENOG41073R8	VanW family
HLK68_RS14345	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HLK68_RS14360	ENOG4105Y5S	NADH ubiquinone oxidoreductase, 24 kD
HLK68_RS14365	ENOG4108VXD	carboxy-peptidase
HLK68_RS14385	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HLK68_RS14390	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HLK68_RS14400	ENOG4105DXU	ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity)
HLK68_RS14410	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HLK68_RS14415	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HLK68_RS14420	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HLK68_RS14425	ENOG4105CAT	Cytidine monophosphate kinase
HLK68_RS14440	ENOG4105FE9	pseudouridine synthase
HLK68_RS14450	ENOG4108JIC	nucleoside recognition domain protein
HLK68_RS14455	ENOG4105DZ1	carboxypeptidase
HLK68_RS14465	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HLK68_RS14485	ENOG4105CZ3	stage V sporulation protein ad
HLK68_RS14490	ENOG41090VF	Stage v sporulation protein ac