locus-tag	class	description
HLK68_RS00020	COG1686	Belongs to the peptidase S11 family
HLK68_RS00025	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HLK68_RS00045	COG0204	Acyl-transferase
HLK68_RS00050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLK68_RS00060	COG2136	Putative SAM-dependent methyltransferase
HLK68_RS00060	COG2521	methyltransferase
HLK68_RS00065	COG2211	Major facilitator Superfamily
HLK68_RS00070	COG0629	single-stranded DNA binding
HLK68_RS00080	COG0612	Peptidase, M16
HLK68_RS00085	COG2340	Cysteine-rich secretory protein family
HLK68_RS00090	COG0813	purine-nucleoside phosphorylase activity
HLK68_RS00095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HLK68_RS00100	COG0628	permease
HLK68_RS00115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLK68_RS00130	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_RS00145	COG1368	sulfuric ester hydrolase activity
HLK68_RS00150	COG4485	Bacterial membrane protein, YfhO
HLK68_RS00170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLK68_RS00190	COG1216	Glycosyl transferase, family 2
HLK68_RS00200	COG0297	glycogen (starch) synthase activity
HLK68_RS00205	COG1216	Glycosyl transferase, family 2
HLK68_RS00205	COG1442	glycosyl transferase family 8
HLK68_RS00210	COG1442	glycosyl transferase family 8
HLK68_RS00210	COG1216	Glycosyl transferase, family 2
HLK68_RS00215	COG1216	Glycosyl transferase, family 2
HLK68_RS00215	COG1442	glycosyl transferase family 8
HLK68_RS00225	COG1316	TRANSCRIPTIONal
HLK68_RS00245	COG0124	histidyl-tRNA synthetase
HLK68_RS00250	COG1490	D-aminoacyl-tRNA deacylase activity
HLK68_RS00255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLK68_RS00260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLK68_RS00265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLK68_RS00265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HLK68_RS00270	COG2244	polysaccharide biosynthetic process
HLK68_RS00275	COG2323	membrane
HLK68_RS00285	COG1862	Preprotein translocase
HLK68_RS00290	COG0343	queuine tRNA-ribosyltransferase activity
HLK68_RS00295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HLK68_RS00310	COG0632	four-way junction helicase activity
HLK68_RS00315	COG2116	formate transmembrane transporter activity
HLK68_RS00345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLK68_RS00370	COG4989	oxidoreductase activity
HLK68_RS00415	COG0733	neurotransmitter:sodium symporter activity
HLK68_RS00430	COG3621	Patatin-like phospholipase
HLK68_RS00465	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HLK68_RS00720	COG0671	phosphoesterase, PA-phosphatase related
HLK68_RS00740	COG0116	Belongs to the methyltransferase superfamily
HLK68_RS00765	COG4677	pectinesterase activity
HLK68_RS00775	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_RS00795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLK68_RS00800	COG2188	Transcriptional regulator
HLK68_RS00805	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HLK68_RS00810	COG4608	Belongs to the ABC transporter superfamily
HLK68_RS00815	COG0444	Belongs to the ABC transporter superfamily
HLK68_RS00825	COG0601	transmembrane transport
HLK68_RS00830	COG0747	negative chemotaxis
HLK68_RS00835	COG0363	glucosamine-6-phosphate deaminase activity
HLK68_RS00840	COG1940	carbohydrate kinase activity
HLK68_RS00855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK68_RS00865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLK68_RS00870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HLK68_RS00880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HLK68_RS00890	COG1994	Peptidase M50
HLK68_RS00925	COG2003	Belongs to the UPF0758 family
HLK68_RS00935	COG0285	dihydrofolate synthase activity
HLK68_RS00960	COG1363	Peptidase, m42
HLK68_RS00970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HLK68_RS00975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HLK68_RS00985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLK68_RS00990	COG1484	DNA-dependent DNA replication
HLK68_RS00995	COG3611	Membrane attachment protein
HLK68_RS01005	COG0237	dephospho-CoA kinase activity
HLK68_RS01025	COG1164	Oligoendopeptidase f
HLK68_RS01030	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HLK68_RS01035	COG4509	Sortase family
HLK68_RS01045	COG0577	efflux transmembrane transporter activity
HLK68_RS01045	COG1136	(ABC) transporter
HLK68_RS01050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLK68_RS01050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLK68_RS01055	COG1408	metallophosphoesterase
HLK68_RS01065	COG2084	Dehydrogenase
HLK68_RS01085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLK68_RS01095	COG2190	(PTS) system
HLK68_RS01095	COG1263	PTS System
HLK68_RS01095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_RS01105	COG0142	geranyltranstransferase activity
HLK68_RS01110	COG1252	NADH dehydrogenase
HLK68_RS01130	COG1051	belongs to the nudix hydrolase family
HLK68_RS01135	COG0469	pyruvate kinase activity
HLK68_RS01140	COG0205	6-phosphofructokinase activity
HLK68_RS01145	COG0587	DNA-directed DNA polymerase activity
HLK68_RS01150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLK68_RS01155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLK68_RS01160	COG0827	DNA restriction-modification system
HLK68_RS01165	COG3874	Sporulation protein YtfJ
HLK68_RS01175	COG0367	asparagine synthase
HLK68_RS01180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HLK68_RS01185	COG2860	membrane
HLK68_RS01190	COG0488	(ABC) transporter
HLK68_RS01195	COG1362	aminopeptidase activity
HLK68_RS01265	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK68_RS01270	COG1045	serine acetyltransferase
HLK68_RS01285	COG1098	S1 RNA binding domain
HLK68_RS01290	COG0492	ferredoxin-NADP+ reductase activity
HLK68_RS01295	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HLK68_RS01300	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLK68_RS01310	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HLK68_RS01315	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HLK68_RS01320	COG0647	UMP catabolic process
HLK68_RS01325	COG4470	Protein conserved in bacteria
HLK68_RS01340	COG0534	Mate efflux family protein
HLK68_RS01345	COG1609	Transcriptional regulator
HLK68_RS01355	COG1126	abc transporter atp-binding protein
HLK68_RS01360	COG0765	amino acid transport
HLK68_RS01370	COG3842	ATPase activity
HLK68_RS01375	COG2508	Transcriptional regulator
HLK68_RS01385	COG2801	Transposase and inactivated derivatives
HLK68_RS01395	COG0564	pseudouridine synthase activity
HLK68_RS01400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HLK68_RS01405	COG2357	RelA SpoT domain protein
HLK68_RS01410	COG4116	CYTH
HLK68_RS01425	COG1393	Belongs to the ArsC family
HLK68_RS01430	COG4608	Belongs to the ABC transporter superfamily
HLK68_RS01435	COG0444	Belongs to the ABC transporter superfamily
HLK68_RS01440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK68_RS01445	COG0601	transmembrane transport
HLK68_RS01450	COG4166	transmembrane transport
HLK68_RS01460	COG1132	(ABC) transporter
HLK68_RS01465	COG1132	(ABC) transporter
HLK68_RS01480	COG0561	phosphatase activity
HLK68_RS01485	COG0495	leucyl-tRNA aminoacylation
HLK68_RS01490	COG1242	4 iron, 4 sulfur cluster binding
HLK68_RS01495	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HLK68_RS01520	COG0149	triose-phosphate isomerase activity
HLK68_RS01525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLK68_RS01530	COG4191	Histidine kinase
HLK68_RS01530	COG0784	Response regulator, receiver
HLK68_RS01535	COG0697	spore germination
HLK68_RS01560	COG4978	Transcriptional regulator
HLK68_RS01560	COG0789	Transcriptional regulator
HLK68_RS01570	COG2205	protein histidine kinase activity
HLK68_RS01575	COG0745	RESPONSE REGULATOR receiver
HLK68_RS01580	COG2267	carboxylic ester hydrolase activity
HLK68_RS01595	COG2205	protein histidine kinase activity
HLK68_RS01600	COG0745	RESPONSE REGULATOR receiver
HLK68_RS01615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLK68_RS01620	COG1757	Na H antiporter
HLK68_RS01645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLK68_RS01655	COG0697	spore germination
HLK68_RS01660	COG0038	chloride channel
HLK68_RS01730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLK68_RS01795	COG1215	transferase activity, transferring glycosyl groups
HLK68_RS01805	COG1442	glycosyl transferase family 8
HLK68_RS01805	COG1216	Glycosyl transferase, family 2
HLK68_RS01810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLK68_RS01820	COG1442	glycosyl transferase family 8
HLK68_RS01820	COG1216	Glycosyl transferase, family 2
HLK68_RS01830	COG0438	transferase activity, transferring glycosyl groups
HLK68_RS01840	COG0463	Glycosyl transferase, family 2
HLK68_RS01840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HLK68_RS01845	COG0438	transferase activity, transferring glycosyl groups
HLK68_RS01860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLK68_RS01865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HLK68_RS01875	COG0489	protein tyrosine kinase activity
HLK68_RS01890	COG1408	metallophosphoesterase
HLK68_RS01895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLK68_RS01900	COG1316	TRANSCRIPTIONal
HLK68_RS01935	COG0489	protein tyrosine kinase activity
HLK68_RS01945	COG1132	(ABC) transporter
HLK68_RS02000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLK68_RS02005	COG0489	protein tyrosine kinase activity
HLK68_RS02030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLK68_RS02055	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLK68_RS02055	COG1902	pentaerythritol trinitrate reductase activity
HLK68_RS02070	COG3279	Response regulator of the LytR AlgR family
HLK68_RS02075	COG3706	GGDEF domain
HLK68_RS02095	COG1881	PFAM PEBP family protein
HLK68_RS02105	COG0351	phosphomethylpyrimidine kinase
HLK68_RS02115	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HLK68_RS02125	COG0756	dUTP diphosphatase activity
HLK68_RS02130	COG0602	queuosine metabolic process
HLK68_RS02135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_RS02135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_RS02135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK68_RS02140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_RS02140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_RS02140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK68_RS02165	COG1328	CTP reductase activity
HLK68_RS02175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLK68_RS02175	COG1328	CTP reductase activity
HLK68_RS02185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLK68_RS02185	COG1328	CTP reductase activity
HLK68_RS02215	COG1121	(ABC) transporter
HLK68_RS02220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLK68_RS02225	COG1121	(ABC) transporter
HLK68_RS02230	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLK68_RS02230	COG3443	Belongs to the bacterial solute-binding protein 9 family
HLK68_RS02245	COG1737	Transcriptional regulator
HLK68_RS02250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK68_RS02265	COG1454	alcohol dehydrogenase
HLK68_RS02270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLK68_RS02275	COG2188	Transcriptional regulator
HLK68_RS02280	COG0366	Alpha amylase catalytic
HLK68_RS02285	COG1263	PTS System
HLK68_RS02285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_RS02305	COG0662	Cupin 2, conserved barrel domain protein
HLK68_RS02305	COG2207	Transcriptional regulator
HLK68_RS02310	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HLK68_RS02330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLK68_RS02340	COG1131	(ABC) transporter
HLK68_RS02365	COG0577	efflux transmembrane transporter activity
HLK68_RS02370	COG1136	(ABC) transporter
HLK68_RS02380	COG0561	phosphatase activity
HLK68_RS02385	COG1349	DNA-binding transcription factor activity
HLK68_RS02395	COG2972	Histidine kinase
HLK68_RS02400	COG2207	Transcriptional regulator
HLK68_RS02400	COG4753	response regulator
HLK68_RS02420	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_RS02425	COG1874	Beta-galactosidase
HLK68_RS02430	COG0546	phosphoglycolate phosphatase activity
HLK68_RS02440	COG1253	flavin adenine dinucleotide binding
HLK68_RS02455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HLK68_RS02480	COG0656	L-ascorbic acid biosynthetic process
HLK68_RS02485	COG0656	L-ascorbic acid biosynthetic process
HLK68_RS02500	COG0402	S-adenosylhomocysteine deaminase activity
HLK68_RS02505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HLK68_RS02510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HLK68_RS02515	COG3842	ATPase activity
HLK68_RS02520	COG0395	ABC-type sugar transport system, permease component
HLK68_RS02525	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK68_RS02530	COG0584	glycerophosphoryl diester phosphodiesterase
HLK68_RS02535	COG1959	2 iron, 2 sulfur cluster binding
HLK68_RS02550	COG0038	chloride channel
HLK68_RS02565	COG1940	carbohydrate kinase activity
HLK68_RS02570	COG1940	carbohydrate kinase activity
HLK68_RS02590	COG0383	alpha-mannosidase activity
HLK68_RS02600	COG0395	ABC-type sugar transport system, permease component
HLK68_RS02605	COG4209	transmembrane transport
HLK68_RS02615	COG2972	Histidine kinase
HLK68_RS02625	COG1482	cell wall glycoprotein biosynthetic process
HLK68_RS02630	COG2723	6-phospho-beta-galactosidase activity
HLK68_RS02635	COG0577	efflux transmembrane transporter activity
HLK68_RS02640	COG1136	(ABC) transporter
HLK68_RS02645	COG0642	Histidine kinase
HLK68_RS02650	COG0745	RESPONSE REGULATOR receiver
HLK68_RS02670	COG1307	EDD domain protein, DegV family
HLK68_RS02675	COG0726	polysaccharide deacetylase
HLK68_RS02690	COG0584	glycerophosphoryl diester phosphodiesterase
HLK68_RS02695	COG2508	Transcriptional regulator
HLK68_RS02725	COG1126	abc transporter atp-binding protein
HLK68_RS02730	COG4215	(ABC) transporter
HLK68_RS02750	COG1028	Short-chain dehydrogenase reductase Sdr
HLK68_RS02755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLK68_RS02765	COG1760	l-serine dehydratase
HLK68_RS02770	COG0556	nucleotide-excision repair
HLK68_RS02775	COG3409	Peptidoglycan-binding domain 1 protein
HLK68_RS02775	COG0793	Belongs to the peptidase S41A family
HLK68_RS02785	COG2177	Part of the ABC transporter FtsEX involved in
HLK68_RS02790	COG2884	Cell division ATP-binding protein ftsE
HLK68_RS02795	COG1854	S-ribosylhomocysteine lyase activity
HLK68_RS02800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HLK68_RS02810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLK68_RS02820	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HLK68_RS02825	COG1105	Belongs to the carbohydrate kinase PfkB family
HLK68_RS02855	COG1307	EDD domain protein, DegV family
HLK68_RS02860	COG1739	Uncharacterized protein family UPF0029
HLK68_RS02865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLK68_RS02870	COG1077	Cell shape determining protein MreB Mrl
HLK68_RS02880	COG2385	sporulation resulting in formation of a cellular spore
HLK68_RS02890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HLK68_RS02895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HLK68_RS02900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HLK68_RS02905	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HLK68_RS02915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HLK68_RS02920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLK68_RS02925	COG0356	it plays a direct role in the translocation of protons across the membrane
HLK68_RS02940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLK68_RS02945	COG0698	ribose 5-phosphate isomerase
HLK68_RS02960	COG0009	L-threonylcarbamoyladenylate synthase
HLK68_RS02965	COG2890	protein-(glutamine-N5) methyltransferase activity
HLK68_RS02970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HLK68_RS02975	COG0305	Participates in initiation and elongation during chromosome replication
HLK68_RS02980	COG0359	binds to the 23S rRNA
HLK68_RS02985	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HLK68_RS03000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HLK68_RS03005	COG0629	single-stranded DNA binding
HLK68_RS03015	COG3639	organic phosphonate transmembrane transporter activity
HLK68_RS03020	COG3639	organic phosphonate transmembrane transporter activity
HLK68_RS03025	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLK68_RS03035	COG0012	GTP binding
HLK68_RS03045	COG1215	transferase activity, transferring glycosyl groups
HLK68_RS03070	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HLK68_RS03120	COG1459	type II secretion system
HLK68_RS03135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLK68_RS03150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLK68_RS03155	COG0084	hydrolase, TatD family'
HLK68_RS03160	COG4608	Belongs to the ABC transporter superfamily
HLK68_RS03165	COG0444	Belongs to the ABC transporter superfamily
HLK68_RS03170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK68_RS03175	COG0601	transmembrane transport
HLK68_RS03180	COG4166	transmembrane transport
HLK68_RS03200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLK68_RS03205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HLK68_RS03215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK68_RS03220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HLK68_RS03225	COG1774	PSP1 C-terminal conserved region
HLK68_RS03230	COG0470	DNA polymerase III
HLK68_RS03235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLK68_RS03250	COG0101	tRNA pseudouridine synthase activity
HLK68_RS03260	COG1122	ATPase activity
HLK68_RS03275	COG1132	(ABC) transporter
HLK68_RS03410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLK68_RS03415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HLK68_RS03425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLK68_RS03430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HLK68_RS03435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLK68_RS03440	COG0534	Mate efflux family protein
HLK68_RS03450	COG0789	Transcriptional regulator
HLK68_RS03460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLK68_RS03465	COG0581	inorganic phosphate transmembrane transporter activity
HLK68_RS03470	COG0573	inorganic phosphate transmembrane transporter activity
HLK68_RS03475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLK68_RS03480	COG5002	protein histidine kinase activity
HLK68_RS03485	COG0745	RESPONSE REGULATOR receiver
HLK68_RS03495	COG0590	tRNA wobble adenosine to inosine editing
HLK68_RS03505	COG1428	Deoxynucleoside kinase
HLK68_RS03510	COG1428	Deoxynucleoside kinase
HLK68_RS03525	COG1918	ferrous iron import across plasma membrane
HLK68_RS03525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HLK68_RS03540	COG1435	thymidine kinase activity
HLK68_RS03545	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLK68_RS03550	COG1473	amidohydrolase
HLK68_RS03585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLK68_RS03590	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HLK68_RS03595	COG0789	Transcriptional regulator
HLK68_RS03600	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HLK68_RS03615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLK68_RS03630	COG0281	malic enzyme
HLK68_RS03640	COG0622	Phosphoesterase
HLK68_RS03660	COG0174	glutamine synthetase
HLK68_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
HLK68_RS03680	COG0284	orotidine-5'-phosphate decarboxylase activity
HLK68_RS03685	COG1733	regulation of RNA biosynthetic process
HLK68_RS03715	COG0543	2 iron, 2 sulfur cluster binding
HLK68_RS03720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLK68_RS03730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLK68_RS03735	COG0540	Belongs to the ATCase OTCase family
HLK68_RS03740	COG2233	PERMEase
HLK68_RS03745	COG1418	mRNA catabolic process
HLK68_RS03760	COG0706	membrane insertase activity
HLK68_RS03765	COG0706	membrane insertase activity
HLK68_RS03770	COG2116	formate transmembrane transporter activity
HLK68_RS03780	COG0426	domain, Protein
HLK68_RS03785	COG1012	belongs to the aldehyde dehydrogenase family
HLK68_RS03785	COG1454	alcohol dehydrogenase
HLK68_RS03790	COG0768	penicillin binding
HLK68_RS03800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLK68_RS03815	COG2252	PERMEase
HLK68_RS03830	COG1363	Peptidase, m42
HLK68_RS03835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLK68_RS03870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLK68_RS03880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLK68_RS03885	COG1592	Rubrerythrin
HLK68_RS03895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLK68_RS03930	COG4464	protein tyrosine phosphatase activity
HLK68_RS03955	COG4607	ABC-type enterochelin transport system periplasmic component
HLK68_RS03960	COG4604	ABC transporter, ATP-binding protein
HLK68_RS03965	COG4605	iron ion homeostasis
HLK68_RS03970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK68_RS03975	COG1917	Cupin 2, conserved barrel domain protein
HLK68_RS03975	COG4977	sequence-specific DNA binding
HLK68_RS03995	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HLK68_RS04000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLK68_RS04020	COG0534	Mate efflux family protein
HLK68_RS04025	COG1725	Transcriptional regulator
HLK68_RS04030	COG1131	(ABC) transporter
HLK68_RS04040	COG1098	S1 RNA binding domain
HLK68_RS04070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLK68_RS04075	COG3956	TIGRFAM MazG family protein
HLK68_RS04080	COG2244	polysaccharide biosynthetic process
HLK68_RS04085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLK68_RS04105	COG1132	(ABC) transporter
HLK68_RS04115	COG1846	Transcriptional regulator
HLK68_RS04125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HLK68_RS04125	COG2199	diguanylate cyclase activity
HLK68_RS04145	COG2205	protein histidine kinase activity
HLK68_RS04150	COG1876	peptidase activity
HLK68_RS04175	COG2801	Transposase and inactivated derivatives
HLK68_RS04230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLK68_RS04235	COG0151	Belongs to the GarS family
HLK68_RS04240	COG0138	bifunctional purine biosynthesis protein purh
HLK68_RS04245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLK68_RS04250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HLK68_RS04255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLK68_RS04260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLK68_RS04270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLK68_RS04275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLK68_RS04285	COG0517	IMP dehydrogenase activity
HLK68_RS04285	COG0516	GMP reductase activity
HLK68_RS04290	COG2002	toxin-antitoxin pair type II binding
HLK68_RS04295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLK68_RS04300	COG0193	aminoacyl-tRNA hydrolase activity
HLK68_RS04305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLK68_RS04310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLK68_RS04315	COG2088	sporulation resulting in formation of a cellular spore
HLK68_RS04320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HLK68_RS04325	COG4466	Protein conserved in bacteria
HLK68_RS04335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLK68_RS04340	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HLK68_RS04345	COG1078	dGTPase activity
HLK68_RS04355	COG4844	belongs to the
HLK68_RS04360	COG0280	phosphate acetyltransferase
HLK68_RS04365	COG3773	Cell wall hydrolase
HLK68_RS04375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HLK68_RS04390	COG0537	adenosine 5'-monophosphoramidase activity
HLK68_RS04400	COG0142	geranyltranstransferase activity
HLK68_RS04405	COG0561	phosphatase activity
HLK68_RS04410	COG1592	Rubrerythrin
HLK68_RS04415	COG1592	Rubrerythrin
HLK68_RS04420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLK68_RS04435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK68_RS04440	COG2011	ABC-type metal ion transport system permease component
HLK68_RS04445	COG1464	Belongs to the NlpA lipoprotein family
HLK68_RS04450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLK68_RS04455	COG1115	amino acid carrier protein
HLK68_RS04470	COG0534	Mate efflux family protein
HLK68_RS04485	COG3546	catalase activity
HLK68_RS04490	COG0659	secondary active sulfate transmembrane transporter activity
HLK68_RS04495	COG0513	Belongs to the DEAD box helicase family
HLK68_RS04500	COG0488	(ABC) transporter
HLK68_RS04535	COG0393	Putative heavy-metal-binding
HLK68_RS04550	COG1733	regulation of RNA biosynthetic process
HLK68_RS04575	COG1595	DNA-templated transcription, initiation
HLK68_RS04580	COG0393	Putative heavy-metal-binding
HLK68_RS04585	COG0217	transcriptional regulatory protein
HLK68_RS04630	COG1397	ADP-ribosylglycohydrolase
HLK68_RS04635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK68_RS04645	COG1482	cell wall glycoprotein biosynthetic process
HLK68_RS04650	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK68_RS04655	COG1940	carbohydrate kinase activity
HLK68_RS04660	COG2723	6-phospho-beta-galactosidase activity
HLK68_RS04665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK68_RS04670	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK68_RS04675	COG1940	carbohydrate kinase activity
HLK68_RS04680	COG2188	Transcriptional regulator
HLK68_RS04685	COG1876	peptidase activity
HLK68_RS04690	COG1595	DNA-templated transcription, initiation
HLK68_RS04715	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK68_RS04730	COG0745	RESPONSE REGULATOR receiver
HLK68_RS04735	COG1741	Belongs to the pirin family
HLK68_RS04740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HLK68_RS04755	COG0584	glycerophosphoryl diester phosphodiesterase
HLK68_RS04770	COG0395	ABC-type sugar transport system, permease component
HLK68_RS04775	COG1175	transmembrane transport
HLK68_RS04780	COG0737	Belongs to the 5'-nucleotidase family
HLK68_RS04790	COG1408	metallophosphoesterase
HLK68_RS04800	COG4978	Transcriptional regulator
HLK68_RS04800	COG0789	Transcriptional regulator
HLK68_RS04845	COG0588	phosphoglycerate mutase activity
HLK68_RS04850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLK68_RS04865	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HLK68_RS04865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLK68_RS04870	COG0387	Pfam Sodium calcium exchanger
HLK68_RS04875	COG3706	GGDEF domain
HLK68_RS04880	COG2824	Alkylphosphonate utilization operon protein PhnA
HLK68_RS04895	COG2223	nitrite transmembrane transporter activity
HLK68_RS04920	COG1357	PFAM Pentapeptide repeats (8 copies)
HLK68_RS04935	COG0786	glutamate:sodium symporter activity
HLK68_RS04940	COG0561	phosphatase activity
HLK68_RS04950	COG2814	Major facilitator Superfamily
HLK68_RS04975	COG3263	regulation of cellular component size
HLK68_RS05000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HLK68_RS05005	COG0739	heme binding
HLK68_RS05010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HLK68_RS05015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLK68_RS05020	COG0187	DNA topoisomerase II activity
HLK68_RS05025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLK68_RS05030	COG2501	S4 domain
HLK68_RS05035	COG4481	Protein conserved in bacteria
HLK68_RS05040	COG0668	transmembrane transport
HLK68_RS05045	COG1475	DNA binding
HLK68_RS05050	COG1192	Involved in chromosome partitioning
HLK68_RS05055	COG1475	DNA binding
HLK68_RS05070	COG4152	abc transporter atp-binding protein
HLK68_RS05075	COG1668	transmembrane transport
HLK68_RS05080	COG0592	DNA-directed DNA polymerase activity
HLK68_RS05105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HLK68_RS05115	COG2502	aspartate--ammonia ligase
HLK68_RS05120	COG0017	Asparaginyl-tRNA synthetase
HLK68_RS05145	COG1523	belongs to the glycosyl hydrolase 13 family
HLK68_RS05160	COG0018	arginyl-trna synthetase
HLK68_RS05190	COG0504	CTP synthase activity
HLK68_RS05200	COG3706	GGDEF domain
HLK68_RS05205	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HLK68_RS05225	COG0745	RESPONSE REGULATOR receiver
HLK68_RS05230	COG2205	protein histidine kinase activity
HLK68_RS05230	COG2770	Histidine kinase
HLK68_RS05235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLK68_RS05240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLK68_RS05245	COG3620	sequence-specific DNA binding
HLK68_RS05250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLK68_RS05255	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLK68_RS05270	COG1501	Belongs to the glycosyl hydrolase 31 family
HLK68_RS05295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLK68_RS05305	COG0366	Alpha amylase catalytic
HLK68_RS05315	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HLK68_RS05340	COG2199	diguanylate cyclase activity
HLK68_RS05340	COG2202	Pas domain
HLK68_RS05340	COG2200	EAL domain
HLK68_RS05350	COG1595	DNA-templated transcription, initiation
HLK68_RS05360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLK68_RS05365	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLK68_RS05380	COG0475	glutathione-regulated potassium exporter activity
HLK68_RS05390	COG1494	fructose-1,6-bisphosphatase
HLK68_RS05395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HLK68_RS05405	COG1695	Transcriptional regulator
HLK68_RS05420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HLK68_RS05440	COG0251	oxidation-reduction process
HLK68_RS05445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLK68_RS05450	COG0215	cysteine-tRNA ligase activity
HLK68_RS05455	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HLK68_RS05460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLK68_RS05470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLK68_RS05475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLK68_RS05485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLK68_RS05490	COG0081	regulation of translation
HLK68_RS05495	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HLK68_RS05500	COG0222	ribosome binding
HLK68_RS05505	COG2813	Specifically methylates the guanine in position
HLK68_RS05510	COG0085	RNA polymerase activity
HLK68_RS05515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLK68_RS05520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLK68_RS05525	COG0049	tRNA binding
HLK68_RS05535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLK68_RS05540	COG0051	transcription antitermination factor activity, RNA binding
HLK68_RS05550	COG0088	Forms part of the polypeptide exit tunnel
HLK68_RS05555	COG0089	rRNA binding
HLK68_RS05560	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLK68_RS05565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLK68_RS05570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HLK68_RS05575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HLK68_RS05580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HLK68_RS05585	COG0255	Belongs to the universal ribosomal protein uL29 family
HLK68_RS05595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HLK68_RS05610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLK68_RS05615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HLK68_RS05625	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HLK68_RS05630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HLK68_RS05635	COG1841	ribosomal large subunit assembly
HLK68_RS05645	COG0201	protein transport
HLK68_RS05650	COG0563	adenylate kinase activity
HLK68_RS05655	COG0024	Methionine aminopeptidase
HLK68_RS05665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLK68_RS05675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HLK68_RS05680	COG0202	RNA polymerase activity
HLK68_RS05690	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HLK68_RS05700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLK68_RS05705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLK68_RS05710	COG1846	Transcriptional regulator
HLK68_RS05715	COG0534	Mate efflux family protein
HLK68_RS05730	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HLK68_RS05735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLK68_RS05750	COG4485	Bacterial membrane protein, YfhO
HLK68_RS05760	COG2267	carboxylic ester hydrolase activity
HLK68_RS05765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLK68_RS05775	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLK68_RS05780	COG0561	phosphatase activity
HLK68_RS05795	COG1058	Belongs to the CinA family
HLK68_RS05795	COG1546	Belongs to the CinA family
HLK68_RS05805	COG0149	triose-phosphate isomerase activity
HLK68_RS05815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLK68_RS05820	COG5658	integral membrane protein
HLK68_RS05830	COG2188	Transcriptional regulator
HLK68_RS05835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLK68_RS05855	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HLK68_RS05860	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_RS05870	COG3859	Proton-coupled thiamine transporter YuaJ
HLK68_RS05875	COG1278	Cold shock
HLK68_RS05905	COG0561	phosphatase activity
HLK68_RS05915	COG1609	Transcriptional regulator
HLK68_RS05920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_RS05920	COG1263	PTS System
HLK68_RS05925	COG1621	beta-fructofuranosidase activity
HLK68_RS05930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLK68_RS05935	COG2239	Acts as a magnesium transporter
HLK68_RS05940	COG0745	RESPONSE REGULATOR receiver
HLK68_RS05945	COG5002	protein histidine kinase activity
HLK68_RS05950	COG2183	response to ionizing radiation
HLK68_RS05965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLK68_RS05970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLK68_RS05980	COG1686	Belongs to the peptidase S11 family
HLK68_RS05990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLK68_RS06025	COG1309	transcriptional regulator
HLK68_RS06030	COG0778	Nitroreductase
HLK68_RS06040	COG4894	glucomannan catabolic process
HLK68_RS06055	COG1136	(ABC) transporter
HLK68_RS06055	COG0577	efflux transmembrane transporter activity
HLK68_RS06070	COG0745	RESPONSE REGULATOR receiver
HLK68_RS06075	COG2205	protein histidine kinase activity
HLK68_RS06080	COG1592	Rubrerythrin
HLK68_RS06100	COG1472	Belongs to the glycosyl hydrolase 3 family
HLK68_RS06115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HLK68_RS06125	COG1737	Transcriptional regulator
HLK68_RS06135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HLK68_RS06150	COG1131	(ABC) transporter
HLK68_RS06155	COG1428	Deoxynucleoside kinase
HLK68_RS06160	COG3344	reverse transcriptase
HLK68_RS06170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLK68_RS06180	COG3655	Transcriptional regulator
HLK68_RS06190	COG3118	belongs to the thioredoxin family
HLK68_RS06215	COG3620	sequence-specific DNA binding
HLK68_RS06225	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLK68_RS06235	COG2207	Transcriptional regulator
HLK68_RS06240	COG0667	Aldo Keto reductase
HLK68_RS06245	COG0456	acetyltransferase
HLK68_RS06250	COG0745	RESPONSE REGULATOR receiver
HLK68_RS06255	COG0642	Histidine kinase
HLK68_RS06265	COG1136	(ABC) transporter
HLK68_RS06265	COG0577	efflux transmembrane transporter activity
HLK68_RS06275	COG0577	efflux transmembrane transporter activity
HLK68_RS06275	COG1136	(ABC) transporter
HLK68_RS06285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLK68_RS06290	COG1328	CTP reductase activity
HLK68_RS06300	COG0733	neurotransmitter:sodium symporter activity
HLK68_RS06305	COG1114	Component of the transport system for branched-chain amino acids
HLK68_RS06330	COG2188	Transcriptional regulator
HLK68_RS06335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLK68_RS06345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_RS06345	COG1263	PTS System
HLK68_RS06355	COG3142	Participates in the control of copper homeostasis
HLK68_RS06370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLK68_RS06375	COG1288	antiporter activity
HLK68_RS06380	COG1473	amidohydrolase
HLK68_RS06385	COG0628	permease
HLK68_RS06395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLK68_RS06440	COG0511	ligase activity, forming carbon-carbon bonds
HLK68_RS06445	COG0439	Biotin carboxylase
HLK68_RS06450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HLK68_RS06465	COG2070	2-Nitropropane dioxygenase
HLK68_RS06470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLK68_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
HLK68_RS06480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLK68_RS06485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLK68_RS06495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLK68_RS06500	COG0739	heme binding
HLK68_RS06570	COG0802	atpase or kinase
HLK68_RS06575	COG1214	PFAM Peptidase M22, glycoprotease
HLK68_RS06595	COG0488	(ABC) transporter
HLK68_RS06600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HLK68_RS06610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLK68_RS06620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HLK68_RS06625	COG0459	protein refolding
HLK68_RS06630	COG0736	holo-[acyl-carrier-protein] synthase activity
HLK68_RS06635	COG2155	Conserved Protein
HLK68_RS06640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLK68_RS06650	COG0745	RESPONSE REGULATOR receiver
HLK68_RS06655	COG5002	protein histidine kinase activity
HLK68_RS06660	COG0436	Aminotransferase
HLK68_RS06670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLK68_RS06675	COG2137	regulation of response to DNA damage stimulus
HLK68_RS06680	COG2188	Transcriptional regulator
HLK68_RS06695	COG0366	Alpha amylase catalytic
HLK68_RS06700	COG0739	heme binding
HLK68_RS06705	COG4536	flavin adenine dinucleotide binding
HLK68_RS06715	COG0463	Glycosyl transferase, family 2
HLK68_RS06725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLK68_RS06730	COG1597	lipid kinase activity
HLK68_RS06735	COG4193	domain, Protein
HLK68_RS06735	COG5263	repeat protein
HLK68_RS06745	COG1442	glycosyl transferase family 8
HLK68_RS06745	COG1216	Glycosyl transferase, family 2
HLK68_RS06750	COG1216	Glycosyl transferase, family 2
HLK68_RS06750	COG1442	glycosyl transferase family 8
HLK68_RS06760	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_RS06775	COG3955	Domain of unknown function (DUF1919)
HLK68_RS06780	COG1215	transferase activity, transferring glycosyl groups
HLK68_RS06790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK68_RS06840	COG2801	Transposase and inactivated derivatives
HLK68_RS06860	COG4193	domain, Protein
HLK68_RS06860	COG5263	repeat protein
HLK68_RS06875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLK68_RS06880	COG0210	DNA helicase
HLK68_RS06885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLK68_RS06895	COG0784	Response regulator, receiver
HLK68_RS06895	COG2205	protein histidine kinase activity
HLK68_RS06900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLK68_RS06910	COG1950	PFAM Membrane protein of
HLK68_RS06920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HLK68_RS06925	COG0546	phosphoglycolate phosphatase activity
HLK68_RS06950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLK68_RS06955	COG1481	regulation of sporulation
HLK68_RS06970	COG0148	phosphopyruvate hydratase activity
HLK68_RS06975	COG0628	permease
HLK68_RS06980	COG0530	calcium, potassium:sodium antiporter activity
HLK68_RS06990	COG0557	exoribonuclease II activity
HLK68_RS06995	COG2843	Capsule synthesis protein
HLK68_RS07000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HLK68_RS07035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLK68_RS07040	COG1116	anion transmembrane transporter activity
HLK68_RS07045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLK68_RS07050	COG3842	ATPase activity
HLK68_RS07055	COG1175	transmembrane transport
HLK68_RS07060	COG0395	ABC-type sugar transport system, permease component
HLK68_RS07065	COG1653	transport
HLK68_RS07070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLK68_RS07075	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HLK68_RS07090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK68_RS07095	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HLK68_RS07100	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HLK68_RS07105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLK68_RS07125	COG1272	protein, Hemolysin III
HLK68_RS07135	COG3681	Belongs to the UPF0597 family
HLK68_RS07140	COG2268	Band 7 protein
HLK68_RS07155	COG0628	permease
HLK68_RS07170	COG2217	Heavy metal translocating P-type atpase
HLK68_RS07180	COG5002	protein histidine kinase activity
HLK68_RS07190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK68_RS07200	COG0583	DNA-binding transcription factor activity
HLK68_RS07205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HLK68_RS07220	COG1233	COG1233 Phytoene dehydrogenase and related
HLK68_RS07230	COG0534	Mate efflux family protein
HLK68_RS07240	COG5002	protein histidine kinase activity
HLK68_RS07250	COG1937	Protein conserved in bacteria
HLK68_RS07260	COG2608	mercury ion transmembrane transporter activity
HLK68_RS07275	COG1136	(ABC) transporter
HLK68_RS07280	COG0577	efflux transmembrane transporter activity
HLK68_RS07290	COG1131	(ABC) transporter
HLK68_RS07310	COG5002	protein histidine kinase activity
HLK68_RS07315	COG3711	transcriptional antiterminator
HLK68_RS07325	COG2190	(PTS) system
HLK68_RS07325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_RS07325	COG1263	PTS System
HLK68_RS07330	COG2723	6-phospho-beta-galactosidase activity
HLK68_RS07355	COG0534	Mate efflux family protein
HLK68_RS07365	COG0590	tRNA wobble adenosine to inosine editing
HLK68_RS07385	COG1234	tRNA 3'-trailer cleavage
HLK68_RS07390	COG0346	lactoylglutathione lyase activity
HLK68_RS07410	COG0277	FAD linked oxidase domain protein
HLK68_RS07415	COG0534	Mate efflux family protein
HLK68_RS07420	COG2033	superoxide reductase activity
HLK68_RS07435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLK68_RS07450	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HLK68_RS07460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK68_RS07465	COG1120	ATPase activity
HLK68_RS07485	COG2364	Membrane
HLK68_RS07490	COG2207	Transcriptional regulator
HLK68_RS07510	COG1136	(ABC) transporter
HLK68_RS07530	COG3153	acetyltransferase
HLK68_RS07545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLK68_RS07565	COG1053	succinate dehydrogenase
HLK68_RS07565	COG3976	FMN-binding domain protein
HLK68_RS07565	COG0431	NADPH-dependent FMN reductase
HLK68_RS07580	COG0515	serine threonine protein kinase
HLK68_RS07580	COG2815	serine threonine protein kinase
HLK68_RS07590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HLK68_RS07595	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HLK68_RS07600	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HLK68_RS07605	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HLK68_RS07625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLK68_RS07645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK68_RS07650	COG1120	ATPase activity
HLK68_RS07675	COG1285	pathogenesis
HLK68_RS07690	COG1061	Type III restriction enzyme res subunit
HLK68_RS07695	COG0494	nUDIX hydrolase
HLK68_RS07740	COG2985	domain, Protein
HLK68_RS07745	COG0785	Cytochrome C biogenesis protein
HLK68_RS07760	COG4592	Periplasmic binding protein
HLK68_RS07765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK68_RS07770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK68_RS07775	COG1120	ATPase activity
HLK68_RS07780	COG2814	Major facilitator Superfamily
HLK68_RS07795	COG0019	diaminopimelate decarboxylase activity
HLK68_RS07800	COG0527	aspartate kinase activity
HLK68_RS07805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLK68_RS07810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK68_RS07815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HLK68_RS07820	COG2171	N-acyltransferase activity
HLK68_RS07825	COG0789	Transcriptional regulator
HLK68_RS07830	COG0656	L-ascorbic acid biosynthetic process
HLK68_RS07835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HLK68_RS07835	COG0517	IMP dehydrogenase activity
HLK68_RS07845	COG2723	6-phospho-beta-galactosidase activity
HLK68_RS07870	COG0583	DNA-binding transcription factor activity
HLK68_RS07875	COG5001	Diguanylate cyclase
HLK68_RS07875	COG3300	MHYT domain
HLK68_RS07895	COG2003	Belongs to the UPF0758 family
HLK68_RS07900	COG4512	PFAM Accessory gene regulator B
HLK68_RS07925	COG2003	Belongs to the UPF0758 family
HLK68_RS07955	COG1136	(ABC) transporter
HLK68_RS07955	COG0577	efflux transmembrane transporter activity
HLK68_RS07980	COG2003	Belongs to the UPF0758 family
HLK68_RS08065	COG1401	restriction endodeoxyribonuclease activity
HLK68_RS08080	COG2003	Belongs to the UPF0758 family
HLK68_RS08110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HLK68_RS08125	COG2003	Belongs to the UPF0758 family
HLK68_RS08215	COG0583	DNA-binding transcription factor activity
HLK68_RS08230	COG0070	glutamate synthase
HLK68_RS08230	COG0069	glutamate synthase activity
HLK68_RS08230	COG0067	glutamate synthase
HLK68_RS08250	COG1533	DNA photolyase activity
HLK68_RS08260	COG1316	TRANSCRIPTIONal
HLK68_RS08265	COG0826	peptidase U32
HLK68_RS08270	COG2323	membrane
HLK68_RS08275	COG0037	tRNA processing
HLK68_RS08300	COG1393	Belongs to the ArsC family
HLK68_RS08310	COG3557	Belongs to the UPF0374 family
HLK68_RS08420	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_RS08425	COG1175	transmembrane transport
HLK68_RS08430	COG3833	ABC-type maltose transport systems, permease component
HLK68_RS08435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLK68_RS08445	COG3620	sequence-specific DNA binding
HLK68_RS08460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLK68_RS08525	COG1192	Involved in chromosome partitioning
HLK68_RS08540	COG0110	maltose O-acetyltransferase activity
HLK68_RS08555	COG2205	protein histidine kinase activity
HLK68_RS08560	COG0745	RESPONSE REGULATOR receiver
HLK68_RS08575	COG3620	sequence-specific DNA binding
HLK68_RS08585	COG1131	(ABC) transporter
HLK68_RS08600	COG1609	Transcriptional regulator
HLK68_RS08605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_RS08605	COG1263	PTS System
HLK68_RS08610	COG1621	beta-fructofuranosidase activity
HLK68_RS08655	COG1175	transmembrane transport
HLK68_RS08660	COG0395	ABC-type sugar transport system, permease component
HLK68_RS08665	COG1486	melibiose metabolic process
HLK68_RS08675	COG2211	Major facilitator Superfamily
HLK68_RS08680	COG0297	glycogen (starch) synthase activity
HLK68_RS08685	COG0024	Methionine aminopeptidase
HLK68_RS08695	COG3250	beta-galactosidase activity
HLK68_RS08700	COG3250	beta-galactosidase activity
HLK68_RS08705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK68_RS08720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLK68_RS08735	COG1609	Transcriptional regulator
HLK68_RS08740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HLK68_RS08745	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HLK68_RS08750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK68_RS08765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLK68_RS08775	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLK68_RS08805	COG0006	proline dipeptidase activity
HLK68_RS08810	COG5398	heme oxygenase
HLK68_RS08825	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLK68_RS08830	COG0396	ATPase activity
HLK68_RS08835	COG0719	Fe-S assembly protein
HLK68_RS08840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLK68_RS08845	COG0822	iron-sulfur transferase activity
HLK68_RS08850	COG0719	Fe-S assembly protein
HLK68_RS08860	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HLK68_RS08865	COG3377	Domain of unknown function (DUF1805)
HLK68_RS08875	COG1136	(ABC) transporter
HLK68_RS08880	COG1136	(ABC) transporter
HLK68_RS08880	COG0577	efflux transmembrane transporter activity
HLK68_RS08895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLK68_RS08900	COG0297	glycogen (starch) synthase activity
HLK68_RS08905	COG0058	SHG alpha-glucan phosphorylase activity
HLK68_RS08930	COG1595	DNA-templated transcription, initiation
HLK68_RS08945	COG0641	radical SAM
HLK68_RS08950	COG3408	Glycogen debranching enzyme
HLK68_RS08950	COG3119	arylsulfatase activity
HLK68_RS08960	COG1061	Type III restriction enzyme res subunit
HLK68_RS08980	COG1653	transport
HLK68_RS08985	COG0613	PHP domain protein
HLK68_RS08995	COG1592	Rubrerythrin
HLK68_RS09020	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HLK68_RS09050	COG4667	esterase of the alpha-beta hydrolase superfamily
HLK68_RS09055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLK68_RS09060	COG0242	peptide deformylase activity
HLK68_RS09065	COG0842	Transport permease protein
HLK68_RS09075	COG1131	(ABC) transporter
HLK68_RS09080	COG2197	response regulator
HLK68_RS09085	COG4585	Histidine kinase
HLK68_RS09110	COG0210	DNA helicase
HLK68_RS09130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK68_RS09135	COG2011	ABC-type metal ion transport system permease component
HLK68_RS09140	COG1464	Belongs to the NlpA lipoprotein family
HLK68_RS09160	COG2985	domain, Protein
HLK68_RS09165	COG3885	ferrous iron binding
HLK68_RS09165	COG2078	PFAM AMMECR1 domain protein
HLK68_RS09190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLK68_RS09195	COG1473	amidohydrolase
HLK68_RS09210	COG1609	Transcriptional regulator
HLK68_RS09215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_RS09215	COG1263	PTS System
HLK68_RS09220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK68_RS09225	COG1621	beta-fructofuranosidase activity
HLK68_RS09235	COG2059	Chromate
HLK68_RS09240	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_RS09250	COG3706	GGDEF domain
HLK68_RS09255	COG0513	Belongs to the DEAD box helicase family
HLK68_RS09260	COG2364	Membrane
HLK68_RS09265	COG1523	belongs to the glycosyl hydrolase 13 family
HLK68_RS09275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLK68_RS09280	COG3481	metal-dependent phosphohydrolase, HD sub domain
HLK68_RS09285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLK68_RS09320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLK68_RS09360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLK68_RS09370	COG0302	gtp cyclohydrolase
HLK68_RS09375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HLK68_RS09380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HLK68_RS09385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLK68_RS09390	COG0457	Tetratricopeptide repeat
HLK68_RS09395	COG2738	Putative neutral zinc metallopeptidase
HLK68_RS09400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK68_RS09410	COG0617	tRNA 3'-terminal CCA addition
HLK68_RS09420	COG3935	DnaD domain protein
HLK68_RS09425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLK68_RS09430	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLK68_RS09430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLK68_RS09450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLK68_RS09455	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLK68_RS09460	COG1418	mRNA catabolic process
HLK68_RS09465	COG1692	metallophosphoesterase
HLK68_RS09470	COG2359	stage V sporulation protein S
HLK68_RS09475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLK68_RS09490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLK68_RS09495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLK68_RS09500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HLK68_RS09505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLK68_RS09535	COG3763	UPF0154 protein
HLK68_RS09545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HLK68_RS09550	COG0187	DNA topoisomerase II activity
HLK68_RS09555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLK68_RS09570	COG1702	phosphate starvation-inducible protein PhoH
HLK68_RS09575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HLK68_RS09580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLK68_RS09585	COG0295	cytidine deaminase activity
HLK68_RS09600	COG1381	Involved in DNA repair and RecF pathway recombination
HLK68_RS09605	COG0423	glycine-tRNA ligase activity
HLK68_RS09610	COG0358	DNA primase activity
HLK68_RS09615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLK68_RS09620	COG2384	SAM-dependent methyltransferase
HLK68_RS09625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLK68_RS09630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HLK68_RS09635	COG0072	phenylalanine-tRNA ligase activity
HLK68_RS09635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLK68_RS09640	COG1605	Chorismate mutase
HLK68_RS09640	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HLK68_RS09645	COG1609	Transcriptional regulator
HLK68_RS09655	COG1917	Cupin 2, conserved barrel domain protein
HLK68_RS09655	COG4977	sequence-specific DNA binding
HLK68_RS09670	COG0583	DNA-binding transcription factor activity
HLK68_RS09680	COG1956	GAF domain-containing protein
HLK68_RS09690	COG1104	cysteine desulfurase activity
HLK68_RS09695	COG0301	tRNA thio-modification
HLK68_RS09700	COG1454	alcohol dehydrogenase
HLK68_RS09700	COG1012	belongs to the aldehyde dehydrogenase family
HLK68_RS09705	COG1136	(ABC) transporter
HLK68_RS09710	COG0577	efflux transmembrane transporter activity
HLK68_RS09735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLK68_RS09740	COG0779	Required for maturation of 30S ribosomal subunits
HLK68_RS09745	COG0195	Participates in both transcription termination and antitermination
HLK68_RS09750	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HLK68_RS09755	COG1358	cellular component organization or biogenesis
HLK68_RS09760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HLK68_RS09765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLK68_RS09775	COG0322	excinuclease ABC activity
HLK68_RS09780	COG2197	response regulator
HLK68_RS09795	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HLK68_RS09805	COG0622	Phosphoesterase
HLK68_RS09835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLK68_RS09835	COG0551	DNA topoisomerase type I activity
HLK68_RS09845	COG0583	DNA-binding transcription factor activity
HLK68_RS09875	COG0569	domain protein
HLK68_RS09910	COG1476	TRANSCRIPTIONal
HLK68_RS09915	COG4086	secreted protein
HLK68_RS09955	COG0561	phosphatase activity
HLK68_RS09965	COG0242	peptide deformylase activity
HLK68_RS10000	COG0772	Belongs to the SEDS family
HLK68_RS10020	COG4471	UPF0298 protein
HLK68_RS10025	COG0228	four-way junction DNA binding
HLK68_RS10030	COG1837	Belongs to the UPF0109 family
HLK68_RS10065	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HLK68_RS10070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLK68_RS10080	COG0181	hydroxymethylbilane synthase activity
HLK68_RS10090	COG0113	porphobilinogen synthase activity
HLK68_RS10095	COG1648	precorrin-2 dehydrogenase activity
HLK68_RS10095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLK68_RS10100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK68_RS10105	COG0765	amino acid transport
HLK68_RS10110	COG1126	abc transporter atp-binding protein
HLK68_RS10120	COG2222	sugar isomerase
HLK68_RS10130	COG2972	Histidine kinase
HLK68_RS10135	COG4753	response regulator
HLK68_RS10135	COG2207	Transcriptional regulator
HLK68_RS10180	COG1175	transmembrane transport
HLK68_RS10185	COG0395	ABC-type sugar transport system, permease component
HLK68_RS10190	COG5426	von Willebrand factor, type A
HLK68_RS10215	COG1846	Transcriptional regulator
HLK68_RS10220	COG0386	Belongs to the glutathione peroxidase family
HLK68_RS10225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK68_RS10230	COG1664	Polymer-forming cytoskeletal
HLK68_RS10230	COG1664	Polymer-forming cytoskeletal
HLK68_RS10235	COG1664	Polymer-forming cytoskeletal
HLK68_RS10245	COG0789	Transcriptional regulator
HLK68_RS10250	COG1132	(ABC) transporter
HLK68_RS10270	COG0561	phosphatase activity
HLK68_RS10335	COG1929	Belongs to the glycerate kinase type-1 family
HLK68_RS10340	COG2610	gluconate transmembrane transporter activity
HLK68_RS10345	COG1842	Phage shock protein A
HLK68_RS10355	COG4260	virion core protein, lumpy skin disease virus
HLK68_RS10375	COG2244	polysaccharide biosynthetic process
HLK68_RS10390	COG1187	pseudouridine synthase activity
HLK68_RS10395	COG0613	PHP domain protein
HLK68_RS10405	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HLK68_RS10415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK68_RS10420	COG1674	ftsk spoiiie
HLK68_RS10425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLK68_RS10450	COG0489	protein tyrosine kinase activity
HLK68_RS10455	COG1323	Belongs to the UPF0348 family
HLK68_RS10460	COG1399	metal-binding, possibly nucleic acid-binding protein
HLK68_RS10465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HLK68_RS10480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HLK68_RS10485	COG0513	Belongs to the DEAD box helicase family
HLK68_RS10490	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HLK68_RS10510	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HLK68_RS10535	COG1940	carbohydrate kinase activity
HLK68_RS10540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLK68_RS10550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HLK68_RS10570	COG4970	Tfp pilus assembly protein FimT
HLK68_RS10575	COG4537	Required for transformation and DNA binding
HLK68_RS10580	COG1459	type II secretion system
HLK68_RS10585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLK68_RS10610	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HLK68_RS10615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLK68_RS10665	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK68_RS10675	COG0004	ammonium transporteR
HLK68_RS10690	COG2333	competence protein COMEC
HLK68_RS10690	COG0658	competence protein
HLK68_RS10695	COG4166	transmembrane transport
HLK68_RS10700	COG0488	(ABC) transporter
HLK68_RS10715	COG1199	ATP-dependent helicase activity
HLK68_RS10720	COG1846	Transcriptional regulator
HLK68_RS10725	COG1132	(ABC) transporter
HLK68_RS10730	COG1132	(ABC) transporter
HLK68_RS10735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLK68_RS10740	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLK68_RS10745	COG0681	Belongs to the peptidase S26 family
HLK68_RS10750	COG0564	pseudouridine synthase activity
HLK68_RS10790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLK68_RS10805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK68_RS10835	COG2153	protein acetylation
HLK68_RS10850	COG0312	modulator of DNA gyrase
HLK68_RS10855	COG0312	modulator of DNA gyrase
HLK68_RS10865	COG4988	ABC transporter
HLK68_RS10870	COG1132	(ABC) transporter
HLK68_RS10880	COG2832	Protein of unknown function (DUF454)
HLK68_RS10915	COG0243	molybdopterin cofactor binding
HLK68_RS10940	COG1979	alcohol dehydrogenase
HLK68_RS10945	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLK68_RS10955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLK68_RS10975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_RS10975	COG2190	(PTS) system
HLK68_RS10975	COG1263	PTS System
HLK68_RS11000	COG2205	protein histidine kinase activity
HLK68_RS11020	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLK68_RS11035	COG0488	(ABC) transporter
HLK68_RS11045	COG0110	maltose O-acetyltransferase activity
HLK68_RS11060	COG1268	BioY protein
HLK68_RS11075	COG0494	nUDIX hydrolase
HLK68_RS11095	COG0303	'Molybdopterin
HLK68_RS11105	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLK68_RS11110	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLK68_RS11115	COG4149	molybdate abc transporter
HLK68_RS11125	COG0315	cyclic pyranopterin monophosphate synthase activity
HLK68_RS11135	COG2258	MOSC domain
HLK68_RS11145	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLK68_RS11160	COG1187	pseudouridine synthase activity
HLK68_RS11180	COG4807	Protein conserved in bacteria
HLK68_RS11190	COG1368	sulfuric ester hydrolase activity
HLK68_RS11230	COG0110	maltose O-acetyltransferase activity
HLK68_RS11250	COG0110	maltose O-acetyltransferase activity
HLK68_RS11255	COG0561	phosphatase activity
HLK68_RS11260	COG0346	lactoylglutathione lyase activity
HLK68_RS11280	COG0252	asparaginase activity
HLK68_RS11285	COG0745	RESPONSE REGULATOR receiver
HLK68_RS11300	COG1132	(ABC) transporter
HLK68_RS11305	COG2378	regulation of single-species biofilm formation
HLK68_RS11310	COG1473	amidohydrolase
HLK68_RS11355	COG0745	RESPONSE REGULATOR receiver
HLK68_RS11360	COG5002	protein histidine kinase activity
HLK68_RS11375	COG1446	asparaginase
HLK68_RS11405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLK68_RS11415	COG1349	DNA-binding transcription factor activity
HLK68_RS11420	COG1105	Belongs to the carbohydrate kinase PfkB family
HLK68_RS11425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_RS11425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK68_RS11425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK68_RS11450	COG0038	chloride channel
HLK68_RS11455	COG0708	Exodeoxyribonuclease III
HLK68_RS11460	COG5002	protein histidine kinase activity
HLK68_RS11465	COG0745	RESPONSE REGULATOR receiver
HLK68_RS11545	COG0640	Transcriptional regulator
HLK68_RS11550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLK68_RS11555	COG0534	Mate efflux family protein
HLK68_RS11580	COG0720	synthase
HLK68_RS11585	COG0602	queuosine metabolic process
HLK68_RS11590	COG0302	gtp cyclohydrolase
HLK68_RS11600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HLK68_RS11605	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HLK68_RS11615	COG0561	phosphatase activity
HLK68_RS11620	COG1803	Methylglyoxal synthase
HLK68_RS11630	COG0671	phosphoesterase, PA-phosphatase related
HLK68_RS11655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLK68_RS11670	COG4166	transmembrane transport
HLK68_RS11675	COG0601	transmembrane transport
HLK68_RS11680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK68_RS11685	COG0444	Belongs to the ABC transporter superfamily
HLK68_RS11720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLK68_RS11725	COG1570	exodeoxyribonuclease VII activity
HLK68_RS11735	COG0142	geranyltranstransferase activity
HLK68_RS11740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLK68_RS11745	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HLK68_RS11750	COG0497	DNA recombination
HLK68_RS11755	COG0750	zinc metalloprotease
HLK68_RS11760	COG0745	RESPONSE REGULATOR receiver
HLK68_RS11765	COG1649	PFAM Uncharacterised BCR, COG1649
HLK68_RS11775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLK68_RS11790	COG0735	belongs to the Fur family
HLK68_RS11795	COG4974	Belongs to the 'phage' integrase family
HLK68_RS11805	COG1827	regulation of RNA biosynthetic process
HLK68_RS11815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK68_RS11820	COG0366	Alpha amylase catalytic
HLK68_RS11825	COG2190	(PTS) system
HLK68_RS11825	COG1263	PTS System
HLK68_RS11825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_RS11860	COG0366	Alpha amylase catalytic
HLK68_RS11890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLK68_RS11895	COG3326	Membrane
HLK68_RS11905	COG2132	Multicopper oxidase
HLK68_RS11910	COG2827	Endonuclease containing a URI domain
HLK68_RS11920	COG1737	Transcriptional regulator
HLK68_RS11930	COG1175	transmembrane transport
HLK68_RS11935	COG0395	ABC-type sugar transport system, permease component
HLK68_RS11940	COG0534	Mate efflux family protein
HLK68_RS11950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLK68_RS11965	COG0737	Belongs to the 5'-nucleotidase family
HLK68_RS12035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLK68_RS12040	COG1115	amino acid carrier protein
HLK68_RS12050	COG1307	EDD domain protein, DegV family
HLK68_RS12055	COG1671	Belongs to the UPF0178 family
HLK68_RS12060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK68_RS12065	COG4129	membrane
HLK68_RS12080	COG1550	Protein conserved in bacteria
HLK68_RS12085	COG0628	permease
HLK68_RS12095	COG0534	Mate efflux family protein
HLK68_RS12100	COG1522	sequence-specific DNA binding
HLK68_RS12105	COG0436	Aminotransferase
HLK68_RS12110	COG0534	Mate efflux family protein
HLK68_RS12120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK68_RS12130	COG4377	Putative membrane peptidase family (DUF2324)
HLK68_RS12135	COG0640	Transcriptional regulator
HLK68_RS12150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK68_RS12180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLK68_RS12185	COG0180	Tryptophanyl-tRNA synthetase
HLK68_RS12200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLK68_RS12210	COG0473	3-isopropylmalate dehydrogenase activity
HLK68_RS12215	COG2226	methyltransferase
HLK68_RS12250	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK68_RS12255	COG3715	PTS system
HLK68_RS12260	COG3716	PTS system mannose fructose sorbose family IID component
HLK68_RS12275	COG3546	catalase activity
HLK68_RS12280	COG3546	catalase activity
HLK68_RS12310	COG1132	(ABC) transporter
HLK68_RS12320	COG2202	Pas domain
HLK68_RS12320	COG2205	protein histidine kinase activity
HLK68_RS12325	COG1331	Highly conserved protein containing a thioredoxin domain
HLK68_RS12335	COG2323	membrane
HLK68_RS12375	COG1061	Type III restriction enzyme res subunit
HLK68_RS12400	COG0656	L-ascorbic acid biosynthetic process
HLK68_RS12415	COG0667	Aldo Keto reductase
HLK68_RS12450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK68_RS12460	COG4565	transcriptional regulatory protein
HLK68_RS12470	COG0667	Aldo Keto reductase
HLK68_RS12490	COG1363	Peptidase, m42
HLK68_RS12495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLK68_RS12520	COG0534	Mate efflux family protein
HLK68_RS12545	COG0561	phosphatase activity
HLK68_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
HLK68_RS12570	COG0367	asparagine synthase
HLK68_RS12580	COG2357	RelA SpoT domain protein
HLK68_RS12585	COG0252	asparaginase activity
HLK68_RS12595	COG1122	ATPase activity
HLK68_RS12600	COG4120	Belongs to the binding-protein-dependent transport system permease family
HLK68_RS12610	COG0723	plastoquinol--plastocyanin reductase activity
HLK68_RS12610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLK68_RS12635	COG0733	neurotransmitter:sodium symporter activity
HLK68_RS12665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLK68_RS12670	COG0010	Belongs to the arginase family
HLK68_RS12675	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HLK68_RS12680	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HLK68_RS12685	COG1982	Orn Lys Arg decarboxylase major
HLK68_RS12715	COG4974	Belongs to the 'phage' integrase family
HLK68_RS12735	COG1523	belongs to the glycosyl hydrolase 13 family
HLK68_RS12750	COG0534	Mate efflux family protein
HLK68_RS12755	COG1028	Short-chain dehydrogenase reductase Sdr
HLK68_RS12765	COG0800	Aldolase
HLK68_RS12785	COG2721	sulfolactate sulfo-lyase activity
HLK68_RS12790	COG0246	Mannitol dehydrogenase
HLK68_RS12795	COG1904	glucuronate isomerase
HLK68_RS12810	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HLK68_RS12815	COG0395	ABC-type sugar transport system, permease component
HLK68_RS12820	COG1175	transmembrane transport
HLK68_RS12855	COG4720	Psort location CytoplasmicMembrane, score
HLK68_RS12860	COG2081	HI0933 family
HLK68_RS12885	COG1177	transmembrane transport
HLK68_RS12890	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK68_RS12895	COG3842	ATPase activity
HLK68_RS12915	COG1466	dna polymerase III delta subunit
HLK68_RS12920	COG2333	competence protein COMEC
HLK68_RS12920	COG0658	competence protein
HLK68_RS12925	COG1555	photosystem II stabilization
HLK68_RS12925	COG1596	polysaccharide export
HLK68_RS12935	COG2226	methyltransferase
HLK68_RS12940	COG0799	negative regulation of ribosome biogenesis
HLK68_RS12945	COG1713	HD superfamily hydrolase involved in NAD metabolism
HLK68_RS12950	COG1534	Rna-binding protein
HLK68_RS12960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HLK68_RS12965	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HLK68_RS12975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HLK68_RS12975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLK68_RS12980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLK68_RS12985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLK68_RS12990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLK68_RS12995	COG0572	uridine kinase
HLK68_RS13010	COG4122	O-methyltransferase activity
HLK68_RS13015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLK68_RS13020	COG3906	Belongs to the UPF0473 family
HLK68_RS13035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLK68_RS13045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLK68_RS13050	COG0482	sulfurtransferase activity
HLK68_RS13070	COG1744	ABC transporter substrate-binding protein PnrA-like
HLK68_RS13095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK68_RS13100	COG0527	aspartate kinase activity
HLK68_RS13105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLK68_RS13110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK68_RS13115	COG0726	polysaccharide deacetylase
HLK68_RS13120	COG1185	polyribonucleotide nucleotidyltransferase activity
HLK68_RS13125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HLK68_RS13130	COG0196	riboflavin kinase activity
HLK68_RS13135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLK68_RS13140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLK68_RS13150	COG0481	GTPase activity
HLK68_RS13165	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HLK68_RS13175	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLK68_RS13190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HLK68_RS13195	COG0268	Binds directly to 16S ribosomal RNA
HLK68_RS13235	COG2826	transposase and inactivated derivatives, IS30 family
HLK68_RS13240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HLK68_RS13245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLK68_RS13250	COG1610	YqeY-like protein
HLK68_RS13255	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HLK68_RS13270	COG2801	Transposase and inactivated derivatives
HLK68_RS13280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLK68_RS13285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLK68_RS13290	COG2264	protein methyltransferase activity
HLK68_RS13295	COG0484	heat shock protein binding
HLK68_RS13300	COG0443	Heat shock 70 kDa protein
HLK68_RS13305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLK68_RS13310	COG1420	regulation of RNA biosynthetic process
HLK68_RS13315	COG3118	belongs to the thioredoxin family
HLK68_RS13325	COG0765	amino acid transport
HLK68_RS13330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK68_RS13335	COG1193	negative regulation of DNA recombination
HLK68_RS13340	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLK68_RS13345	COG0705	Rhomboid family
HLK68_RS13345	COG0457	Tetratricopeptide repeat
HLK68_RS13350	COG0564	pseudouridine synthase activity
HLK68_RS13355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HLK68_RS13375	COG1695	Transcriptional regulator
HLK68_RS13380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLK68_RS13385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLK68_RS13395	COG2302	S4 RNA-binding domain
HLK68_RS13400	COG0762	integral membrane protein
HLK68_RS13405	COG1799	cell septum assembly
HLK68_RS13410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLK68_RS13415	COG1873	PFAM PRC-barrel domain
HLK68_RS13420	COG1191	sigma factor activity
HLK68_RS13425	COG1191	sigma factor activity
HLK68_RS13440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLK68_RS13445	COG0849	cell division
HLK68_RS13455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HLK68_RS13460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLK68_RS13465	COG0772	Belongs to the SEDS family
HLK68_RS13470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLK68_RS13475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLK68_RS13480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLK68_RS13485	COG0768	penicillin binding
HLK68_RS13500	COG0275	rRNA processing
HLK68_RS13505	COG2001	Belongs to the MraZ family
HLK68_RS13515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLK68_RS13520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HLK68_RS13525	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLK68_RS13575	COG3069	C4-dicarboxylate transmembrane transporter activity
HLK68_RS13585	COG0210	DNA helicase
HLK68_RS13605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK68_RS13610	COG0673	inositol 2-dehydrogenase activity
HLK68_RS13615	COG1114	Component of the transport system for branched-chain amino acids
HLK68_RS13630	COG0475	glutathione-regulated potassium exporter activity
HLK68_RS13650	COG1227	inorganic diphosphatase activity
HLK68_RS13660	COG2271	Major facilitator Superfamily
HLK68_RS13665	COG2267	carboxylic ester hydrolase activity
HLK68_RS13675	COG2176	DNA-directed DNA polymerase activity
HLK68_RS13685	COG0750	zinc metalloprotease
HLK68_RS13695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLK68_RS13715	COG0233	cytoplasmic translational termination
HLK68_RS13720	COG0528	UMP kinase activity
HLK68_RS13725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HLK68_RS13735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLK68_RS13740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLK68_RS13755	COG4974	Belongs to the 'phage' integrase family
HLK68_RS13765	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HLK68_RS13775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLK68_RS13780	COG0726	polysaccharide deacetylase
HLK68_RS13785	COG0758	DNA mediated transformation
HLK68_RS13810	COG0335	large ribosomal subunit rRNA binding
HLK68_RS13820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLK68_RS13825	COG2878	Part of a membrane complex involved in electron transport
HLK68_RS13835	COG4657	Part of a membrane complex involved in electron transport
HLK68_RS13840	COG4660	Part of a membrane complex involved in electron transport
HLK68_RS13850	COG4658	electron transport chain
HLK68_RS13855	COG4656	Part of a membrane complex involved in electron transport
HLK68_RS13885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HLK68_RS13890	COG0742	ribosomal rna small subunit methyltransferase
HLK68_RS13910	COG1785	Belongs to the alkaline phosphatase family
HLK68_RS13915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLK68_RS13920	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HLK68_RS13925	COG0552	protein localization to endoplasmic reticulum
HLK68_RS13930	COG1196	nuclear chromosome segregation
HLK68_RS13955	COG1012	belongs to the aldehyde dehydrogenase family
HLK68_RS14010	COG1115	amino acid carrier protein
HLK68_RS14055	COG0463	Glycosyl transferase, family 2
HLK68_RS14100	COG1595	DNA-templated transcription, initiation
HLK68_RS14125	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HLK68_RS14140	COG0419	ATPase involved in DNA repair
HLK68_RS14145	COG0420	3'-5' exonuclease activity
HLK68_RS14150	COG1609	Transcriptional regulator
HLK68_RS14185	COG0300	oxidoreductase activity
HLK68_RS14200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLK68_RS14205	COG1461	Dihydroxyacetone kinase
HLK68_RS14210	COG1302	Protein conserved in bacteria
HLK68_RS14215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLK68_RS14240	COG1564	THIamine pyrophosphokinase
HLK68_RS14245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLK68_RS14250	COG1162	GTPase activity
HLK68_RS14255	COG2815	serine threonine protein kinase
HLK68_RS14255	COG0515	serine threonine protein kinase
HLK68_RS14260	COG0631	protein serine/threonine phosphatase activity
HLK68_RS14270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLK68_RS14270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLK68_RS14275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK68_RS14280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK68_RS14285	COG2996	Protein conserved in bacteria
HLK68_RS14300	COG0426	domain, Protein
HLK68_RS14305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLK68_RS14315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLK68_RS14320	COG1758	RNA polymerase activity
HLK68_RS14325	COG0194	GDP metabolic process
HLK68_RS14335	COG2720	vancomycin resistance protein
HLK68_RS14345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLK68_RS14360	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HLK68_RS14365	COG1876	peptidase activity
HLK68_RS14380	COG0772	Belongs to the SEDS family
HLK68_RS14385	COG1074	ATP-dependent DNA helicase activity
HLK68_RS14390	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HLK68_RS14400	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLK68_RS14410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HLK68_RS14415	COG1160	GTP binding
HLK68_RS14420	COG0539	negative regulation of cytoplasmic translation
HLK68_RS14425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HLK68_RS14435	COG1141	Ferredoxin
HLK68_RS14440	COG1187	pseudouridine synthase activity
HLK68_RS14445	COG0700	Nucleoside recognition
HLK68_RS14450	COG2715	membrane protein required for spore maturation
HLK68_RS14455	COG1686	Belongs to the peptidase S11 family
HLK68_RS14465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLK68_RS14475	COG0697	spore germination
HLK68_RS14485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids