locus-tag	class	description
DSM104440_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DSM104440_RS00010	COG0592	DNA-directed DNA polymerase activity
DSM104440_RS00025	COG0758	DNA mediated transformation
DSM104440_RS00035	COG0242	peptide deformylase activity
DSM104440_RS00040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM104440_RS00050	COG5000	phosphorelay sensor kinase activity
DSM104440_RS00055	COG2204	response regulator
DSM104440_RS00070	COG4608	Belongs to the ABC transporter superfamily
DSM104440_RS00075	COG0444	Belongs to the ABC transporter superfamily
DSM104440_RS00080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM104440_RS00085	COG0601	transmembrane transport
DSM104440_RS00090	COG0747	negative chemotaxis
DSM104440_RS00145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DSM104440_RS00150	COG2863	cytochrome
DSM104440_RS00160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DSM104440_RS00165	COG0352	thiamine-phosphate diphosphorylase activity
DSM104440_RS00170	COG0351	phosphomethylpyrimidine kinase
DSM104440_RS00195	COG0840	transmembrane signaling receptor activity
DSM104440_RS00200	COG2198	Histidine kinase
DSM104440_RS00200	COG0784	Response regulator, receiver
DSM104440_RS00200	COG0643	Histidine kinase
DSM104440_RS00205	COG3507	Belongs to the glycosyl hydrolase 43 family
DSM104440_RS00215	COG0596	Alpha beta hydrolase
DSM104440_RS00225	COG1968	undecaprenyl-diphosphatase activity
DSM104440_RS00240	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DSM104440_RS00255	COG1131	(ABC) transporter
DSM104440_RS00260	COG0842	Transport permease protein
DSM104440_RS00265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM104440_RS00280	COG0859	PFAM glycosyl transferase family 9
DSM104440_RS00330	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DSM104440_RS00345	COG1137	ATPase activity
DSM104440_RS00350	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DSM104440_RS00355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DSM104440_RS00360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM104440_RS00365	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DSM104440_RS00370	COG1660	Displays ATPase and GTPase activities
DSM104440_RS00390	COG3275	phosphorelay sensor kinase activity
DSM104440_RS00395	COG3279	Response regulator of the LytR AlgR family
DSM104440_RS00405	COG2022	thiamine diphosphate biosynthetic process
DSM104440_RS00415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DSM104440_RS00425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSM104440_RS00430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DSM104440_RS00435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DSM104440_RS00440	COG0631	protein serine/threonine phosphatase activity
DSM104440_RS00445	COG2815	serine threonine protein kinase
DSM104440_RS00445	COG0515	serine threonine protein kinase
DSM104440_RS00450	COG1561	YicC-like family, N-terminal region
DSM104440_RS00455	COG0194	GDP metabolic process
DSM104440_RS00460	COG1758	RNA polymerase activity
DSM104440_RS00465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSM104440_RS00475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DSM104440_RS00480	COG3161	chorismate lyase activity
DSM104440_RS00485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DSM104440_RS00490	COG2249	NAD(P)H dehydrogenase (quinone) activity
DSM104440_RS00500	COG0183	Belongs to the thiolase family
DSM104440_RS00520	COG0659	secondary active sulfate transmembrane transporter activity
DSM104440_RS00565	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
DSM104440_RS00675	COG4974	Belongs to the 'phage' integrase family
DSM104440_RS00705	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104440_RS00710	COG1960	acyl-CoA dehydrogenase activity
DSM104440_RS00720	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS00725	COG0183	Belongs to the thiolase family
DSM104440_RS00730	COG1024	Enoyl-CoA hydratase
DSM104440_RS00730	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM104440_RS00740	COG1137	ATPase activity
DSM104440_RS00750	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM104440_RS00755	COG0683	leucine binding
DSM104440_RS00760	COG1960	acyl-CoA dehydrogenase activity
DSM104440_RS00765	COG1960	acyl-CoA dehydrogenase activity
DSM104440_RS00770	COG2045	Belongs to the ComB family
DSM104440_RS00775	COG0300	oxidoreductase activity
DSM104440_RS00785	COG1414	Transcriptional regulator
DSM104440_RS00810	COG1530	ribonuclease E activity
DSM104440_RS00815	COG0424	maF-like protein
DSM104440_RS00825	COG0799	negative regulation of ribosome biogenesis
DSM104440_RS00830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DSM104440_RS00835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DSM104440_RS00850	COG0495	leucyl-tRNA aminoacylation
DSM104440_RS00880	COG0210	DNA helicase
DSM104440_RS00895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DSM104440_RS00910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM104440_RS00910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM104440_RS00915	COG0009	L-threonylcarbamoyladenylate synthase
DSM104440_RS00940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM104440_RS00940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM104440_RS00950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM104440_RS00985	COG0138	bifunctional purine biosynthesis protein purh
DSM104440_RS00990	COG0151	Belongs to the GarS family
DSM104440_RS01030	COG2815	serine threonine protein kinase
DSM104440_RS01030	COG0515	serine threonine protein kinase
DSM104440_RS01070	COG4654	Cytochrome c, class I
DSM104440_RS01075	COG1331	Highly conserved protein containing a thioredoxin domain
DSM104440_RS01090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM104440_RS01095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DSM104440_RS01125	COG0667	Aldo Keto reductase
DSM104440_RS01155	COG0129	dihydroxy-acid dehydratase activity
DSM104440_RS01165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DSM104440_RS01190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104440_RS01235	COG2197	response regulator
DSM104440_RS01245	COG4585	Histidine kinase
DSM104440_RS01255	COG5487	UPF0391 membrane protein
DSM104440_RS01270	COG4575	ribosome binding
DSM104440_RS01275	COG2823	Periplasmic or secreted lipoprotein
DSM104440_RS01290	COG3237	CsbD-like
DSM104440_RS01295	COG0628	permease
DSM104440_RS01310	COG0745	RESPONSE REGULATOR receiver
DSM104440_RS01315	COG2205	protein histidine kinase activity
DSM104440_RS01320	COG5001	Diguanylate cyclase
DSM104440_RS01335	COG0626	cystathionine gamma-synthase activity
DSM104440_RS01340	COG3001	Fructosamine kinase
DSM104440_RS01585	COG2329	Antibiotic biosynthesis monooxygenase
DSM104440_RS01620	COG1435	thymidine kinase activity
DSM104440_RS01630	COG0346	lactoylglutathione lyase activity
DSM104440_RS01670	COG0640	Transcriptional regulator
DSM104440_RS01845	COG0456	acetyltransferase
DSM104440_RS01845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DSM104440_RS01880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DSM104440_RS01885	COG0454	-acetyltransferase
DSM104440_RS01900	COG5001	Diguanylate cyclase
DSM104440_RS01900	COG3706	GGDEF domain
DSM104440_RS01900	COG2203	Gaf domain
DSM104440_RS01900	COG4251	negative regulation of phosphorylation
DSM104440_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS01965	COG0681	Belongs to the peptidase S26 family
DSM104440_RS01970	COG1120	ATPase activity
DSM104440_RS01975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM104440_RS01980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DSM104440_RS01985	COG1305	Transglutaminase-like
DSM104440_RS01990	COG1910	domain protein
DSM104440_RS02015	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DSM104440_RS02020	COG4149	molybdate abc transporter
DSM104440_RS02025	COG0725	ABC transporter, periplasmic molybdate-binding protein
DSM104440_RS02035	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DSM104440_RS02050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DSM104440_RS02055	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DSM104440_RS02075	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DSM104440_RS02080	COG0237	dephospho-CoA kinase activity
DSM104440_RS02085	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DSM104440_RS02090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DSM104440_RS02100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DSM104440_RS02105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM104440_RS02110	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DSM104440_RS02120	COG1845	cytochrome c oxidase, subunit III
DSM104440_RS02140	COG0109	protoheme IX farnesyltransferase activity
DSM104440_RS02145	COG1999	signal sequence binding
DSM104440_RS02160	COG2177	Part of the ABC transporter FtsEX involved in
DSM104440_RS02165	COG2884	Cell division ATP-binding protein ftsE
DSM104440_RS02175	COG0742	ribosomal rna small subunit methyltransferase
DSM104440_RS02180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DSM104440_RS02185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DSM104440_RS02195	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM104440_RS02205	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DSM104440_RS02210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DSM104440_RS02220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DSM104440_RS02225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DSM104440_RS02230	COG0193	aminoacyl-tRNA hydrolase activity
DSM104440_RS02235	COG0012	GTP binding
DSM104440_RS02275	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104440_RS02295	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM104440_RS02315	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS02320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DSM104440_RS02325	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104440_RS02355	COG1702	phosphate starvation-inducible protein PhoH
DSM104440_RS02360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DSM104440_RS02365	COG4535	Mg2 and Co2 transporter CorC
DSM104440_RS02370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DSM104440_RS02390	COG0752	glycyl-tRNA synthetase alpha subunit
DSM104440_RS02395	COG0751	glycine-tRNA ligase activity
DSM104440_RS02400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DSM104440_RS02420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DSM104440_RS02425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DSM104440_RS02430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104440_RS02435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DSM104440_RS02450	COG0006	proline dipeptidase activity
DSM104440_RS02455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM104440_RS02460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM104440_RS02465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSM104440_RS02470	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DSM104440_RS02475	COG2967	ApaG domain
DSM104440_RS02480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DSM104440_RS02495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM104440_RS02500	COG0134	indole-3-glycerol-phosphate synthase activity
DSM104440_RS02510	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DSM104440_RS02515	COG1765	OsmC-like protein
DSM104440_RS02520	COG0628	permease
DSM104440_RS02525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DSM104440_RS02530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DSM104440_RS02535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DSM104440_RS02550	COG0316	Belongs to the HesB IscA family
DSM104440_RS02555	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DSM104440_RS02560	COG4942	peptidase
DSM104440_RS02565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DSM104440_RS02595	COG3795	YCII-related domain
DSM104440_RS02620	COG0308	aminopeptidase N
DSM104440_RS02625	COG0513	Belongs to the DEAD box helicase family
DSM104440_RS02640	COG1053	succinate dehydrogenase
DSM104440_RS02650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104440_RS02675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DSM104440_RS02680	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DSM104440_RS02685	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DSM104440_RS02690	COG2224	Isocitrate lyase
DSM104440_RS02700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM104440_RS02750	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DSM104440_RS02750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM104440_RS02755	COG3118	belongs to the thioredoxin family
DSM104440_RS02800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104440_RS02825	COG2391	methyltransferase activity
DSM104440_RS02835	COG5002	protein histidine kinase activity
DSM104440_RS02835	COG5001	Diguanylate cyclase
DSM104440_RS02835	COG3447	MASE1 domain protein
DSM104440_RS02840	COG1127	ABC transporter
DSM104440_RS02850	COG1595	DNA-templated transcription, initiation
DSM104440_RS02880	COG3011	Protein conserved in bacteria
DSM104440_RS02890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM104440_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS02930	COG0129	dihydroxy-acid dehydratase activity
DSM104440_RS02940	COG0488	(ABC) transporter
DSM104440_RS02970	COG1408	metallophosphoesterase
DSM104440_RS02985	COG5487	UPF0391 membrane protein
DSM104440_RS03010	COG0747	negative chemotaxis
DSM104440_RS03020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104440_RS03025	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DSM104440_RS03035	COG0861	Integral membrane protein TerC family
DSM104440_RS03040	COG4452	Inner membrane protein CreD
DSM104440_RS03060	COG0745	RESPONSE REGULATOR receiver
DSM104440_RS03070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104440_RS03100	COG0484	heat shock protein binding
DSM104440_RS03115	COG3384	dioxygenase
DSM104440_RS03125	COG0793	Belongs to the peptidase S41A family
DSM104440_RS03125	COG3409	Peptidoglycan-binding domain 1 protein
DSM104440_RS03145	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DSM104440_RS03165	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DSM104440_RS03175	COG1376	ErfK ybiS ycfS ynhG family protein
DSM104440_RS03180	COG0277	FAD linked oxidase domain protein
DSM104440_RS03185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DSM104440_RS03195	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DSM104440_RS03200	COG0792	nuclease activity
DSM104440_RS03205	COG3107	peptidoglycan biosynthetic process
DSM104440_RS03215	COG0418	dihydroorotase activity
DSM104440_RS03295	COG2001	Belongs to the MraZ family
DSM104440_RS03300	COG0275	rRNA processing
DSM104440_RS03305	COG3116	cell division
DSM104440_RS03315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM104440_RS03320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DSM104440_RS03325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM104440_RS03330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DSM104440_RS03335	COG0772	Belongs to the SEDS family
DSM104440_RS03340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DSM104440_RS03345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSM104440_RS03350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DSM104440_RS03355	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM104440_RS03360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DSM104440_RS03390	COG0739	heme binding
DSM104440_RS03395	COG0653	protein targeting
DSM104440_RS03400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DSM104440_RS03405	COG2226	methyltransferase
DSM104440_RS03415	COG0494	nUDIX hydrolase
DSM104440_RS03420	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
DSM104440_RS03425	COG1116	anion transmembrane transporter activity
DSM104440_RS03425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM104440_RS03430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM104440_RS03435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM104440_RS03445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DSM104440_RS03450	COG2226	methyltransferase
DSM104440_RS03455	COG2267	carboxylic ester hydrolase activity
DSM104440_RS03460	COG0156	8-amino-7-oxononanoate synthase activity
DSM104440_RS03465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DSM104440_RS03470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DSM104440_RS03475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DSM104440_RS03530	COG3188	usher protein
DSM104440_RS03540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DSM104440_RS03550	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DSM104440_RS03575	COG0588	phosphoglycerate mutase activity
DSM104440_RS03580	COG4942	peptidase
DSM104440_RS03585	COG0793	Belongs to the peptidase S41A family
DSM104440_RS03590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSM104440_RS03610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DSM104440_RS03615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSM104440_RS03620	COG1610	YqeY-like protein
DSM104440_RS03635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104440_RS03660	COG1832	CoA-binding protein
DSM104440_RS03670	COG0330	HflC and HflK could
DSM104440_RS03700	COG1960	acyl-CoA dehydrogenase activity
DSM104440_RS03705	COG0183	Belongs to the thiolase family
DSM104440_RS03735	COG1022	Amp-dependent synthetase and ligase
DSM104440_RS03740	COG1024	Enoyl-CoA hydratase
DSM104440_RS03745	COG2130	NADP-dependent
DSM104440_RS03755	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM104440_RS03755	COG1024	Enoyl-CoA hydratase
DSM104440_RS03765	COG0183	Belongs to the thiolase family
DSM104440_RS03810	COG0678	peroxiredoxin activity
DSM104440_RS03815	COG1280	lysine exporter protein (LysE YggA)
DSM104440_RS03820	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS03825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSM104440_RS03835	COG1956	GAF domain-containing protein
DSM104440_RS03900	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DSM104440_RS03905	COG2815	serine threonine protein kinase
DSM104440_RS03905	COG0515	serine threonine protein kinase
DSM104440_RS03920	COG5002	protein histidine kinase activity
DSM104440_RS03930	COG0784	Response regulator, receiver
DSM104440_RS03935	COG0277	FAD linked oxidase domain protein
DSM104440_RS03940	COG0277	FAD linked oxidase domain protein
DSM104440_RS03945	COG0277	FAD linked oxidase domain protein
DSM104440_RS03950	COG0247	lactate metabolic process
DSM104440_RS03960	COG0254	rRNA binding
DSM104440_RS03970	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DSM104440_RS03980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DSM104440_RS03990	COG4251	negative regulation of phosphorylation
DSM104440_RS03995	COG0784	Response regulator, receiver
DSM104440_RS04005	COG1294	oxidase, subunit
DSM104440_RS04010	COG1271	oxidase subunit
DSM104440_RS04020	COG1074	ATP-dependent DNA helicase activity
DSM104440_RS04045	COG2267	carboxylic ester hydrolase activity
DSM104440_RS04050	COG3132	Protein of unknown function, DUF480
DSM104440_RS04075	COG0583	DNA-binding transcription factor activity
DSM104440_RS04080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DSM104440_RS04105	COG2186	Transcriptional regulator
DSM104440_RS04110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM104440_RS04130	COG0756	dUTP diphosphatase activity
DSM104440_RS04135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DSM104440_RS04140	COG2003	Belongs to the UPF0758 family
DSM104440_RS04145	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DSM104440_RS04150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DSM104440_RS04155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DSM104440_RS04160	COG0840	transmembrane signaling receptor activity
DSM104440_RS04175	COG3264	Mechanosensitive ion channel
DSM104440_RS04175	COG1511	domain protein
DSM104440_RS04180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DSM104440_RS04180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM104440_RS04190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DSM104440_RS04195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DSM104440_RS04200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DSM104440_RS04205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DSM104440_RS04215	COG0617	tRNA 3'-terminal CCA addition
DSM104440_RS04225	COG1428	Deoxynucleoside kinase
DSM104440_RS04230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DSM104440_RS04235	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DSM104440_RS04240	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DSM104440_RS04250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM104440_RS04280	COG0662	Cupin 2, conserved barrel domain protein
DSM104440_RS04285	COG1850	ribulose-bisphosphate carboxylase activity
DSM104440_RS04305	COG0243	molybdopterin cofactor binding
DSM104440_RS04310	COG2146	nitrite reductase [NAD(P)H] activity
DSM104440_RS04315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSM104440_RS04320	COG1116	anion transmembrane transporter activity
DSM104440_RS04325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM104440_RS04330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM104440_RS04335	COG3707	response regulator
DSM104440_RS04345	COG2274	protein secretion by the type I secretion system
DSM104440_RS04350	COG2274	protein secretion by the type I secretion system
DSM104440_RS04385	COG4771	TonB-dependent receptor
DSM104440_RS04390	COG1609	Transcriptional regulator
DSM104440_RS04405	COG0395	ABC-type sugar transport system, permease component
DSM104440_RS04410	COG2723	6-phospho-beta-galactosidase activity
DSM104440_RS04430	COG0583	DNA-binding transcription factor activity
DSM104440_RS04445	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DSM104440_RS04455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DSM104440_RS04470	COG0577	efflux transmembrane transporter activity
DSM104440_RS04470	COG1136	(ABC) transporter
DSM104440_RS04490	COG3655	Transcriptional regulator
DSM104440_RS04505	COG0697	spore germination
DSM104440_RS04520	COG0354	folic acid binding
DSM104440_RS04530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM104440_RS04530	COG0047	phosphoribosylformylglycinamidine synthase activity
DSM104440_RS04570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104440_RS04575	COG0271	Belongs to the BolA IbaG family
DSM104440_RS04580	COG2917	probably involved in intracellular septation
DSM104440_RS04590	COG0613	PHP domain protein
DSM104440_RS04595	COG0009	L-threonylcarbamoyladenylate synthase
DSM104440_RS04600	COG1994	Peptidase M50
DSM104440_RS04605	COG0180	Tryptophanyl-tRNA synthetase
DSM104440_RS04615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DSM104440_RS04620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DSM104440_RS04635	COG0583	DNA-binding transcription factor activity
DSM104440_RS04650	COG1335	isochorismatase
DSM104440_RS04660	COG3795	YCII-related domain
DSM104440_RS04670	COG0259	pyridoxamine-phosphate oxidase activity
DSM104440_RS04700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM104440_RS04720	COG2171	N-acyltransferase activity
DSM104440_RS04725	COG0436	Aminotransferase
DSM104440_RS04730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM104440_RS04735	COG0463	Glycosyl transferase, family 2
DSM104440_RS04745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DSM104440_RS04765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DSM104440_RS04770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DSM104440_RS04775	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DSM104440_RS04785	COG0242	peptide deformylase activity
DSM104440_RS04810	COG0024	Methionine aminopeptidase
DSM104440_RS04815	COG0052	Belongs to the universal ribosomal protein uS2 family
DSM104440_RS04820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DSM104440_RS04825	COG0528	UMP kinase activity
DSM104440_RS04830	COG0233	cytoplasmic translational termination
DSM104440_RS04835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DSM104440_RS04840	COG0575	Belongs to the CDS family
DSM104440_RS04865	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104440_RS04870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM104440_RS04875	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104440_RS04880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104440_RS04885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DSM104440_RS04890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM104440_RS04905	COG1752	Esterase of the alpha-beta hydrolase superfamily
DSM104440_RS04915	COG3240	lipase activity
DSM104440_RS04915	COG4625	pathogenesis
DSM104440_RS04920	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DSM104440_RS04930	COG2153	protein acetylation
DSM104440_RS04940	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS04950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM104440_RS04955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DSM104440_RS04965	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DSM104440_RS05035	COG3706	GGDEF domain
DSM104440_RS05060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DSM104440_RS05065	COG1053	succinate dehydrogenase
DSM104440_RS05080	COG0674	pyruvate-flavodoxin oxidoreductase activity
DSM104440_RS05085	COG1013	pyruvate-flavodoxin oxidoreductase activity
DSM104440_RS05090	COG0493	'glutamate synthase
DSM104440_RS05095	COG0281	malic enzyme
DSM104440_RS05125	COG1007	ATP synthesis coupled electron transport
DSM104440_RS05135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DSM104440_RS05140	COG0713	ATP synthesis coupled electron transport
DSM104440_RS05150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104440_RS05155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DSM104440_RS05160	COG1034	ATP synthesis coupled electron transport
DSM104440_RS05175	COG0649	NAD binding
DSM104440_RS05180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104440_RS05185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104440_RS05200	COG2267	carboxylic ester hydrolase activity
DSM104440_RS05205	COG3278	Belongs to the heme-copper respiratory oxidase family
DSM104440_RS05245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSM104440_RS05245	COG0045	succinate-CoA ligase (ADP-forming) activity
DSM104440_RS05245	COG1042	CoA-binding domain protein
DSM104440_RS05265	COG0589	response to stress
DSM104440_RS05275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104440_RS05280	COG2201	protein-glutamate methylesterase activity
DSM104440_RS05295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSM104440_RS05330	COG2070	2-Nitropropane dioxygenase
DSM104440_RS05350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM104440_RS05375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM104440_RS05405	COG4654	Cytochrome c, class I
DSM104440_RS05410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104440_RS05425	COG1272	protein, Hemolysin III
DSM104440_RS05435	COG3154	lipid carrier protein
DSM104440_RS05440	COG0826	peptidase U32
DSM104440_RS05445	COG0826	peptidase U32
DSM104440_RS05450	COG2832	Protein of unknown function (DUF454)
DSM104440_RS05455	COG1959	2 iron, 2 sulfur cluster binding
DSM104440_RS05460	COG3256	nitric oxide reductase
DSM104440_RS05470	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM104440_RS05475	COG3005	denitrification pathway
DSM104440_RS05480	COG3043	anaerobic respiration
DSM104440_RS05485	COG0243	molybdopterin cofactor binding
DSM104440_RS05490	COG3062	negative regulation of establishment of protein localization
DSM104440_RS05515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSM104440_RS05565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DSM104440_RS05570	COG0670	Belongs to the BI1 family
DSM104440_RS05595	COG5001	Diguanylate cyclase
DSM104440_RS05605	COG1505	serine-type exopeptidase activity
DSM104440_RS05630	COG4191	Histidine kinase
DSM104440_RS05630	COG0784	Response regulator, receiver
DSM104440_RS05675	COG0069	glutamate synthase activity
DSM104440_RS05690	COG0786	glutamate:sodium symporter activity
DSM104440_RS05720	COG1612	heme a metabolic process
DSM104440_RS05740	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS05745	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM104440_RS05760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM104440_RS05775	COG1137	ATPase activity
DSM104440_RS05785	COG0488	(ABC) transporter
DSM104440_RS05810	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DSM104440_RS05830	COG1012	belongs to the aldehyde dehydrogenase family
DSM104440_RS05835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DSM104440_RS05850	COG2267	carboxylic ester hydrolase activity
DSM104440_RS05855	COG2066	Belongs to the glutaminase family
DSM104440_RS05870	COG1228	amidohydrolase
DSM104440_RS05885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DSM104440_RS05895	COG1129	ABC transporter
DSM104440_RS05905	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM104440_RS05915	COG3800	Transcriptional regulator
DSM104440_RS05915	COG1396	sequence-specific DNA binding
DSM104440_RS05930	COG5002	protein histidine kinase activity
DSM104440_RS05940	COG1283	sodium-dependent phosphate transmembrane transporter activity
DSM104440_RS05945	COG1012	belongs to the aldehyde dehydrogenase family
DSM104440_RS05980	COG0583	DNA-binding transcription factor activity
DSM104440_RS05985	COG1840	ABC-type Fe3 transport system, periplasmic component
DSM104440_RS05990	COG3842	ATPase activity
DSM104440_RS06000	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM104440_RS06015	COG2226	methyltransferase
DSM104440_RS06020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM104440_RS06025	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DSM104440_RS06030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104440_RS06045	COG2850	peptidyl-arginine hydroxylation
DSM104440_RS06050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM104440_RS06055	COG1047	Peptidyl-prolyl cis-trans
DSM104440_RS06065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DSM104440_RS06075	COG1652	LysM domain
DSM104440_RS06085	COG1252	NADH dehydrogenase
DSM104440_RS06090	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DSM104440_RS06100	COG1045	serine acetyltransferase
DSM104440_RS06110	COG1104	cysteine desulfurase activity
DSM104440_RS06115	COG0822	iron-sulfur transferase activity
DSM104440_RS06120	COG0316	Belongs to the HesB IscA family
DSM104440_RS06125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DSM104440_RS06130	COG0443	Heat shock 70 kDa protein
DSM104440_RS06145	COG0683	leucine binding
DSM104440_RS06155	COG2204	response regulator
DSM104440_RS06165	COG2205	protein histidine kinase activity
DSM104440_RS06175	COG0560	Phosphoserine phosphatase
DSM104440_RS06180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DSM104440_RS06185	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DSM104440_RS06185	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DSM104440_RS06210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM104440_RS06220	COG5002	protein histidine kinase activity
DSM104440_RS06225	COG4566	intracellular signal transduction
DSM104440_RS06245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DSM104440_RS06260	COG0745	RESPONSE REGULATOR receiver
DSM104440_RS06290	COG0028	Belongs to the TPP enzyme family
DSM104440_RS06300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSM104440_RS06305	COG0688	phosphatidylethanolamine metabolic process
DSM104440_RS06310	COG1183	phosphatidylcholine synthase activity
DSM104440_RS06315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM104440_RS06325	COG0656	L-ascorbic acid biosynthetic process
DSM104440_RS06340	COG0625	glutathione transferase activity
DSM104440_RS06345	COG0482	sulfurtransferase activity
DSM104440_RS06360	COG0538	isocitrate dehydrogenase activity
DSM104440_RS06365	COG1278	Cold shock
DSM104440_RS06370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DSM104440_RS06375	COG0542	response to heat
DSM104440_RS06385	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM104440_RS06390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSM104440_RS06395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSM104440_RS06405	COG0433	COG0433 Predicted ATPase
DSM104440_RS06410	COG0217	transcriptional regulatory protein
DSM104440_RS06415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DSM104440_RS06420	COG0632	four-way junction helicase activity
DSM104440_RS06425	COG2255	four-way junction helicase activity
DSM104440_RS06430	COG0824	Thioesterase
DSM104440_RS06440	COG0848	biopolymer transport protein
DSM104440_RS06450	COG0823	Involved in the tonB-independent uptake of proteins
DSM104440_RS06465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DSM104440_RS06500	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DSM104440_RS06525	COG2251	uridine kinase activity
DSM104440_RS06525	COG0195	Participates in both transcription termination and antitermination
DSM104440_RS06530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DSM104440_RS06535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DSM104440_RS06540	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DSM104440_RS06545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DSM104440_RS06550	COG1185	polyribonucleotide nucleotidyltransferase activity
DSM104440_RS06570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DSM104440_RS06580	COG2914	Belongs to the UPF0125 (RnfH) family
DSM104440_RS06610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DSM104440_RS06610	COG0519	Catalyzes the synthesis of GMP from XMP
DSM104440_RS06615	COG4677	pectinesterase activity
DSM104440_RS06620	COG3618	amidohydrolase
DSM104440_RS06630	COG1393	Belongs to the ArsC family
DSM104440_RS06635	COG5001	Diguanylate cyclase
DSM104440_RS06635	COG3706	GGDEF domain
DSM104440_RS06635	COG2203	Gaf domain
DSM104440_RS06635	COG4251	negative regulation of phosphorylation
DSM104440_RS06640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM104440_RS06640	COG2205	protein histidine kinase activity
DSM104440_RS06670	COG1254	Belongs to the acylphosphatase family
DSM104440_RS06685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104440_RS06685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104440_RS06690	COG0489	protein tyrosine kinase activity
DSM104440_RS06695	COG0717	Belongs to the dCTP deaminase family
DSM104440_RS06700	COG0019	diaminopimelate decarboxylase activity
DSM104440_RS06735	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DSM104440_RS06760	COG1355	regulation of microtubule-based process
DSM104440_RS06765	COG3885	ferrous iron binding
DSM104440_RS06765	COG2078	PFAM AMMECR1 domain protein
DSM104440_RS06775	COG1162	GTPase activity
DSM104440_RS06780	COG2154	pterin-4-alpha-carbinolamine dehydratase
DSM104440_RS06785	COG0501	Belongs to the peptidase M48B family
DSM104440_RS06790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DSM104440_RS06800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DSM104440_RS06820	COG1653	transport
DSM104440_RS06825	COG1175	transmembrane transport
DSM104440_RS06830	COG0395	ABC-type sugar transport system, permease component
DSM104440_RS06845	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
DSM104440_RS06855	COG1546	Belongs to the CinA family
DSM104440_RS06860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DSM104440_RS06865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DSM104440_RS06870	COG2137	regulation of response to DNA damage stimulus
DSM104440_RS06880	COG1335	isochorismatase
DSM104440_RS06900	COG1872	DUF167
DSM104440_RS06910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSM104440_RS06915	COG2816	NAD+ diphosphatase activity
DSM104440_RS06935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM104440_RS06940	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM104440_RS06945	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DSM104440_RS06965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSM104440_RS06970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DSM104440_RS06975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DSM104440_RS07000	COG1136	(ABC) transporter
DSM104440_RS07000	COG0577	efflux transmembrane transporter activity
DSM104440_RS07005	COG1136	(ABC) transporter
DSM104440_RS07005	COG0577	efflux transmembrane transporter activity
DSM104440_RS07010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104440_RS07025	COG4783	chaperone-mediated protein folding
DSM104440_RS07030	COG0315	cyclic pyranopterin monophosphate synthase activity
DSM104440_RS07045	COG0425	Belongs to the sulfur carrier protein TusA family
DSM104440_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS07060	COG0525	valine-tRNA ligase activity
DSM104440_RS07075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM104440_RS07115	COG0543	2 iron, 2 sulfur cluster binding
DSM104440_RS07115	COG0493	'glutamate synthase
DSM104440_RS07120	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DSM104440_RS07130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DSM104440_RS07145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DSM104440_RS07155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DSM104440_RS07160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DSM104440_RS07165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DSM104440_RS07210	COG2205	protein histidine kinase activity
DSM104440_RS07230	COG1585	Membrane protein implicated in regulation of membrane protease activity
DSM104440_RS07235	COG2268	Band 7 protein
DSM104440_RS07260	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104440_RS07275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM104440_RS07285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104440_RS07290	COG1609	Transcriptional regulator
DSM104440_RS07300	COG2755	lipolytic protein G-D-S-L family
DSM104440_RS07325	COG0673	inositol 2-dehydrogenase activity
DSM104440_RS07340	COG1619	proteins homologs of microcin C7 resistance protein MccF
DSM104440_RS07350	COG3023	N-Acetylmuramoyl-L-alanine amidase
DSM104440_RS07355	COG4166	transmembrane transport
DSM104440_RS07360	COG2715	membrane protein required for spore maturation
DSM104440_RS07375	COG2124	cytochrome p450
DSM104440_RS07380	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DSM104440_RS07380	COG1672	PFAM Archaeal ATPase
DSM104440_RS07390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DSM104440_RS07395	COG1619	proteins homologs of microcin C7 resistance protein MccF
DSM104440_RS07400	COG0346	lactoylglutathione lyase activity
DSM104440_RS07405	COG0280	phosphate acetyltransferase
DSM104440_RS07405	COG0281	malic enzyme
DSM104440_RS07465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DSM104440_RS07470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DSM104440_RS07480	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DSM104440_RS07515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM104440_RS07520	COG3549	Plasmid maintenance system killer
DSM104440_RS07530	COG1278	Cold shock
DSM104440_RS07540	COG0066	3-isopropylmalate dehydratase activity
DSM104440_RS07545	COG0473	3-isopropylmalate dehydrogenase activity
DSM104440_RS07565	COG0135	phosphoribosylanthranilate isomerase activity
DSM104440_RS07570	COG0133	tryptophan synthase activity
DSM104440_RS07575	COG0159	tryptophan synthase activity
DSM104440_RS07580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DSM104440_RS07585	COG0285	dihydrofolate synthase activity
DSM104440_RS07640	COG0215	cysteine-tRNA ligase activity
DSM104440_RS07650	COG0683	leucine binding
DSM104440_RS07660	COG0443	Heat shock 70 kDa protein
DSM104440_RS07665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DSM104440_RS07670	COG1950	PFAM Membrane protein of
DSM104440_RS07675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DSM104440_RS07680	COG1420	regulation of RNA biosynthetic process
DSM104440_RS07685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DSM104440_RS07690	COG0497	DNA recombination
DSM104440_RS07710	COG0400	carboxylic ester hydrolase activity
DSM104440_RS07715	COG0521	Mo-molybdopterin cofactor biosynthetic process
DSM104440_RS07720	COG3028	Belongs to the UPF0307 family
DSM104440_RS07725	COG0312	modulator of DNA gyrase
DSM104440_RS07730	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM104440_RS07740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM104440_RS07750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104440_RS07770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSM104440_RS07775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DSM104440_RS07780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM104440_RS07780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM104440_RS07795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DSM104440_RS07800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM104440_RS07805	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DSM104440_RS07810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DSM104440_RS07815	COG0584	glycerophosphoryl diester phosphodiesterase
DSM104440_RS07840	COG0678	peroxiredoxin activity
DSM104440_RS07840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DSM104440_RS07845	COG0583	DNA-binding transcription factor activity
DSM104440_RS07850	COG1309	transcriptional regulator
DSM104440_RS07880	COG1592	Rubrerythrin
DSM104440_RS07900	COG1228	amidohydrolase
DSM104440_RS07915	COG2264	protein methyltransferase activity
DSM104440_RS07925	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DSM104440_RS07980	COG0393	Putative heavy-metal-binding
DSM104440_RS08020	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DSM104440_RS08025	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DSM104440_RS08030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSM104440_RS08030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DSM104440_RS08035	COG0666	response to abiotic stimulus
DSM104440_RS08040	COG1174	glycine betaine transport
DSM104440_RS08055	COG2986	histidine ammonia-lyase
DSM104440_RS08100	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS08105	COG0129	dihydroxy-acid dehydratase activity
DSM104440_RS08110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM104440_RS08115	COG3842	ATPase activity
DSM104440_RS08125	COG1175	transmembrane transport
DSM104440_RS08135	COG3833	ABC-type maltose transport systems, permease component
DSM104440_RS08145	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DSM104440_RS08150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM104440_RS08160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM104440_RS08165	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DSM104440_RS08170	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM104440_RS08175	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS08190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM104440_RS08195	COG2721	sulfolactate sulfo-lyase activity
DSM104440_RS08200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM104440_RS08205	COG0589	response to stress
DSM104440_RS08215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSM104440_RS08225	COG1320	monovalent cation:proton antiporter activity
DSM104440_RS08230	COG2212	antiporter activity
DSM104440_RS08235	COG1863	multisubunit Na H antiporter MnhE subunit
DSM104440_RS08240	COG0651	ATP synthesis coupled electron transport
DSM104440_RS08245	COG1006	Multisubunit Na H antiporter MnhC subunit
DSM104440_RS08250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DSM104440_RS08250	COG2111	Na H antiporter
DSM104440_RS08255	COG1253	flavin adenine dinucleotide binding
DSM104440_RS08285	COG0840	transmembrane signaling receptor activity
DSM104440_RS08290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104440_RS08310	COG4771	TonB-dependent receptor
DSM104440_RS08330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM104440_RS08390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DSM104440_RS08400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DSM104440_RS08435	COG2358	TRAP transporter, solute receptor (TAXI family
DSM104440_RS08440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM104440_RS08535	COG0697	spore germination
DSM104440_RS08540	COG0039	L-malate dehydrogenase activity
DSM104440_RS08570	COG1392	Phosphate transport regulator
DSM104440_RS08575	COG0306	phosphate transporter
DSM104440_RS08595	COG4106	trans-aconitate 2-methyltransferase activity
DSM104440_RS08600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DSM104440_RS08625	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DSM104440_RS08635	COG2079	MmgE PrpD family protein
DSM104440_RS08660	COG2030	dehydratase
DSM104440_RS08665	COG2301	Belongs to the HpcH HpaI aldolase family
DSM104440_RS08680	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DSM104440_RS08685	COG1053	succinate dehydrogenase
DSM104440_RS08690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DSM104440_RS08695	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DSM104440_RS08700	COG0372	Belongs to the citrate synthase family
DSM104440_RS08705	COG0567	Dehydrogenase, E1 component
DSM104440_RS08710	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM104440_RS08725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM104440_RS08730	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DSM104440_RS08755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DSM104440_RS08760	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104440_RS08775	COG1024	Enoyl-CoA hydratase
DSM104440_RS08820	COG0488	(ABC) transporter
DSM104440_RS08830	COG2086	electron transfer activity
DSM104440_RS08840	COG1960	acyl-CoA dehydrogenase activity
DSM104440_RS08845	COG1971	Probably functions as a manganese efflux pump
DSM104440_RS08870	COG2133	pyrroloquinoline quinone binding
DSM104440_RS08880	COG3228	Belongs to the MtfA family
DSM104440_RS08905	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM104440_RS08910	COG1024	Enoyl-CoA hydratase
DSM104440_RS08915	COG1024	Enoyl-CoA hydratase
DSM104440_RS08940	COG4191	Histidine kinase
DSM104440_RS08970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM104440_RS09000	COG4770	biotin carboxylase activity
DSM104440_RS09020	COG1024	Enoyl-CoA hydratase
DSM104440_RS09025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM104440_RS09035	COG1960	acyl-CoA dehydrogenase activity
DSM104440_RS09050	COG0183	Belongs to the thiolase family
DSM104440_RS09065	COG1960	acyl-CoA dehydrogenase activity
DSM104440_RS09080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104440_RS09095	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM104440_RS09120	COG3842	ATPase activity
DSM104440_RS09125	COG1840	ABC-type Fe3 transport system, periplasmic component
DSM104440_RS09165	COG4555	ABC transporter
DSM104440_RS09175	COG1199	ATP-dependent helicase activity
DSM104440_RS09225	COG1214	PFAM Peptidase M22, glycoprotease
DSM104440_RS09235	COG1573	uracil-dna glycosylase
DSM104440_RS09245	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DSM104440_RS09255	COG1414	Transcriptional regulator
DSM104440_RS09265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104440_RS09275	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DSM104440_RS09290	COG4133	protoheme IX ABC transporter activity
DSM104440_RS09345	COG0477	Major facilitator Superfamily
DSM104440_RS09385	COG0745	RESPONSE REGULATOR receiver
DSM104440_RS09400	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DSM104440_RS09405	COG2201	protein-glutamate methylesterase activity
DSM104440_RS09410	COG0835	chemotaxis
DSM104440_RS09415	COG2815	serine threonine protein kinase
DSM104440_RS09415	COG0515	serine threonine protein kinase
DSM104440_RS09420	COG0840	transmembrane signaling receptor activity
DSM104440_RS09425	COG0835	chemotaxis
DSM104440_RS09435	COG0674	pyruvate-flavodoxin oxidoreductase activity
DSM104440_RS09435	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DSM104440_RS09440	COG1013	pyruvate-flavodoxin oxidoreductase activity
DSM104440_RS09450	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DSM104440_RS09485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DSM104440_RS09490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM104440_RS09495	COG0726	polysaccharide deacetylase
DSM104440_RS09505	COG4772	TonB-dependent receptor
DSM104440_RS09515	COG2346	COG2346, Truncated hemoglobins
DSM104440_RS09545	COG1322	Protein conserved in bacteria
DSM104440_RS09555	COG0473	3-isopropylmalate dehydrogenase activity
DSM104440_RS09560	COG1763	Mo-molybdopterin cofactor biosynthetic process
DSM104440_RS09565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DSM104440_RS09570	COG0314	molybdopterin synthase activity
DSM104440_RS09590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DSM104440_RS09595	COG4654	Cytochrome c, class I
DSM104440_RS09620	COG2010	Cytochrome c
DSM104440_RS09655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DSM104440_RS09680	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DSM104440_RS09770	COG0640	Transcriptional regulator
DSM104440_RS09795	COG0587	DNA-directed DNA polymerase activity
DSM104440_RS09830	COG0784	Response regulator, receiver
DSM104440_RS09830	COG4191	Histidine kinase
DSM104440_RS09880	COG2985	domain, Protein
DSM104440_RS09885	COG2721	sulfolactate sulfo-lyase activity
DSM104440_RS09895	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104440_RS09900	COG3391	amine dehydrogenase activity
DSM104440_RS09915	COG2204	response regulator
DSM104440_RS09920	COG2204	response regulator
DSM104440_RS09945	COG2823	Periplasmic or secreted lipoprotein
DSM104440_RS09955	COG0114	fumarate hydratase activity
DSM104440_RS09960	COG3038	cytochrome b561
DSM104440_RS09965	COG2353	YceI-like domain
DSM104440_RS09970	COG2353	YceI-like domain
DSM104440_RS09985	COG0823	Involved in the tonB-independent uptake of proteins
DSM104440_RS09985	COG1506	peptidase
DSM104440_RS10010	COG0672	)-iron permease
DSM104440_RS10015	COG4774	siderophore transport
DSM104440_RS10040	COG1960	acyl-CoA dehydrogenase activity
DSM104440_RS10060	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104440_RS10065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM104440_RS10070	COG0277	FAD linked oxidase domain protein
DSM104440_RS10070	COG0247	lactate metabolic process
DSM104440_RS10075	COG2186	Transcriptional regulator
DSM104440_RS10080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM104440_RS10085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM104440_RS10130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSM104440_RS10135	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104440_RS10195	COG4221	oxidoreductase activity
DSM104440_RS10200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM104440_RS10205	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DSM104440_RS10215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104440_RS10220	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DSM104440_RS10225	COG0084	hydrolase, TatD family'
DSM104440_RS10230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM104440_RS10245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DSM104440_RS10250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DSM104440_RS10255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM104440_RS10260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM104440_RS10265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DSM104440_RS10280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM104440_RS10285	COG0416	fatty acid biosynthetic process
DSM104440_RS10290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DSM104440_RS10295	COG1399	metal-binding, possibly nucleic acid-binding protein
DSM104440_RS10300	COG0424	maF-like protein
DSM104440_RS10305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DSM104440_RS10325	COG0546	phosphoglycolate phosphatase activity
DSM104440_RS10330	COG0564	pseudouridine synthase activity
DSM104440_RS10335	COG1530	ribonuclease E activity
DSM104440_RS10350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSM104440_RS10355	COG0556	nucleotide-excision repair
DSM104440_RS10360	COG0436	Aminotransferase
DSM104440_RS10365	COG3459	Glycosyltransferase 36 associated
DSM104440_RS10380	COG0667	Aldo Keto reductase
DSM104440_RS10390	COG4214	carbohydrate transport
DSM104440_RS10395	COG4213	ABC transporter substrate-binding protein
DSM104440_RS10400	COG2115	Belongs to the xylose isomerase family
DSM104440_RS10405	COG2115	Belongs to the xylose isomerase family
DSM104440_RS10410	COG1070	Carbohydrate kinase
DSM104440_RS10420	COG0395	ABC-type sugar transport system, permease component
DSM104440_RS10425	COG1175	transmembrane transport
DSM104440_RS10440	COG4771	TonB-dependent receptor
DSM104440_RS10445	COG3661	Belongs to the glycosyl hydrolase 67 family
DSM104440_RS10450	COG1472	Belongs to the glycosyl hydrolase 3 family
DSM104440_RS10455	COG1472	Belongs to the glycosyl hydrolase 3 family
DSM104440_RS10465	COG0840	transmembrane signaling receptor activity
DSM104440_RS10485	COG3507	Belongs to the glycosyl hydrolase 43 family
DSM104440_RS10510	COG1566	PFAM secretion protein HlyD family protein
DSM104440_RS10540	COG1187	pseudouridine synthase activity
DSM104440_RS10550	COG2264	protein methyltransferase activity
DSM104440_RS10565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104440_RS10575	COG3195	allantoin biosynthetic process
DSM104440_RS10575	COG3648	Uricase
DSM104440_RS10595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM104440_RS10610	COG0402	S-adenosylhomocysteine deaminase activity
DSM104440_RS10615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DSM104440_RS10620	COG1744	ABC transporter substrate-binding protein PnrA-like
DSM104440_RS10625	COG1609	Transcriptional regulator
DSM104440_RS10630	COG3845	ABC transporter
DSM104440_RS10635	COG4603	Belongs to the binding-protein-dependent transport system permease family
DSM104440_RS10640	COG1079	Belongs to the binding-protein-dependent transport system permease family
DSM104440_RS10660	COG1012	belongs to the aldehyde dehydrogenase family
DSM104440_RS10675	COG1525	nuclease
DSM104440_RS10675	COG0737	Belongs to the 5'-nucleotidase family
DSM104440_RS10675	COG4085	toxin activity
DSM104440_RS10680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM104440_RS10690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DSM104440_RS10725	COG0322	excinuclease ABC activity
DSM104440_RS10735	COG0736	holo-[acyl-carrier-protein] synthase activity
DSM104440_RS10740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DSM104440_RS10745	COG1381	Involved in DNA repair and RecF pathway recombination
DSM104440_RS10750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DSM104440_RS10755	COG0571	ribonuclease III activity
DSM104440_RS10765	COG0681	Belongs to the peptidase S26 family
DSM104440_RS10770	COG0481	GTPase activity
DSM104440_RS10780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104440_RS10800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DSM104440_RS10805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DSM104440_RS10805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DSM104440_RS10815	COG0517	IMP dehydrogenase activity
DSM104440_RS10815	COG0516	GMP reductase activity
DSM104440_RS10820	COG1136	(ABC) transporter
DSM104440_RS10825	COG0577	efflux transmembrane transporter activity
DSM104440_RS10835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DSM104440_RS10835	COG2755	lipolytic protein G-D-S-L family
DSM104440_RS10840	COG0519	Catalyzes the synthesis of GMP from XMP
DSM104440_RS10855	COG1024	Enoyl-CoA hydratase
DSM104440_RS10860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104440_RS10885	COG5001	Diguanylate cyclase
DSM104440_RS10885	COG3300	MHYT domain
DSM104440_RS10890	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM104440_RS10905	COG2050	protein possibly involved in aromatic compounds catabolism
DSM104440_RS10920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DSM104440_RS10925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DSM104440_RS10940	COG0243	molybdopterin cofactor binding
DSM104440_RS10955	COG0006	proline dipeptidase activity
DSM104440_RS10960	COG1802	Transcriptional regulator
DSM104440_RS10965	COG3938	Belongs to the proline racemase family
DSM104440_RS10970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM104440_RS10985	COG1506	peptidase
DSM104440_RS10985	COG0823	Involved in the tonB-independent uptake of proteins
DSM104440_RS10995	COG1917	Cupin 2, conserved barrel domain protein
DSM104440_RS10995	COG2169	Transcriptional regulator
DSM104440_RS11000	COG0346	lactoylglutathione lyase activity
DSM104440_RS11010	COG0596	Alpha beta hydrolase
DSM104440_RS11065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSM104440_RS11080	COG0300	oxidoreductase activity
DSM104440_RS11105	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DSM104440_RS11125	COG0732	type I restriction modification DNA specificity domain
DSM104440_RS11130	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DSM104440_RS11140	COG0542	response to heat
DSM104440_RS11145	COG1215	transferase activity, transferring glycosyl groups
DSM104440_RS11180	COG0436	Aminotransferase
DSM104440_RS11190	COG0484	heat shock protein binding
DSM104440_RS11195	COG0484	heat shock protein binding
DSM104440_RS11200	COG2902	Dehydrogenase
DSM104440_RS11205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM104440_RS11210	COG0765	amino acid transport
DSM104440_RS11215	COG0765	amino acid transport
DSM104440_RS11220	COG1126	abc transporter atp-binding protein
DSM104440_RS11240	COG0714	Associated with various cellular activities
DSM104440_RS11265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM104440_RS11270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DSM104440_RS11275	COG3590	peptidase
DSM104440_RS11280	COG3964	amidohydrolase
DSM104440_RS11290	COG0509	glycine decarboxylation via glycine cleavage system
DSM104440_RS11295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM104440_RS11300	COG0156	8-amino-7-oxononanoate synthase activity
DSM104440_RS11305	COG1063	alcohol dehydrogenase
DSM104440_RS11325	COG3842	ATPase activity
DSM104440_RS11340	COG0546	phosphoglycolate phosphatase activity
DSM104440_RS11360	COG0776	regulation of translation
DSM104440_RS11365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104440_RS11365	COG0072	phenylalanine-tRNA ligase activity
DSM104440_RS11370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DSM104440_RS11375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DSM104440_RS11380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DSM104440_RS11385	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DSM104440_RS11390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DSM104440_RS11395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DSM104440_RS11400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DSM104440_RS11430	COG0829	nickel cation binding
DSM104440_RS11435	COG0831	urea catabolic process
DSM104440_RS11440	COG0832	Belongs to the urease beta subunit family
DSM104440_RS11445	COG0804	urea catabolic process
DSM104440_RS11450	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DSM104440_RS11455	COG0830	nickel cation binding
DSM104440_RS11460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DSM104440_RS11490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSM104440_RS11500	COG2308	Evidence 4 Homologs of previously reported genes of
DSM104440_RS11540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DSM104440_RS11580	COG1136	(ABC) transporter
DSM104440_RS11595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DSM104440_RS11600	COG4771	TonB-dependent receptor
DSM104440_RS11615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DSM104440_RS11625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM104440_RS11630	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DSM104440_RS11645	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS11650	COG1505	serine-type exopeptidase activity
DSM104440_RS11655	COG2197	response regulator
DSM104440_RS11660	COG4585	Histidine kinase
DSM104440_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS11680	COG3243	poly(R)-hydroxyalkanoic acid synthase
DSM104440_RS11695	COG0564	pseudouridine synthase activity
DSM104440_RS11705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DSM104440_RS11710	COG0248	Ppx GppA phosphatase
DSM104440_RS11715	COG2062	phosphohistidine phosphatase, SixA
DSM104440_RS11730	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DSM104440_RS11735	COG4181	ATPase activity
DSM104440_RS11745	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DSM104440_RS11750	COG0515	serine threonine protein kinase
DSM104440_RS11750	COG2815	serine threonine protein kinase
DSM104440_RS11755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DSM104440_RS11760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DSM104440_RS11765	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DSM104440_RS11770	COG0406	alpha-ribazole phosphatase activity
DSM104440_RS11775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DSM104440_RS11780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DSM104440_RS11795	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DSM104440_RS11800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSM104440_RS11805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM104440_RS11810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DSM104440_RS11815	COG1674	ftsk spoiiie
DSM104440_RS11825	COG0492	ferredoxin-NADP+ reductase activity
DSM104440_RS11835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DSM104440_RS11840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DSM104440_RS11890	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104440_RS11900	COG1024	Enoyl-CoA hydratase
DSM104440_RS11905	COG1596	polysaccharide export
DSM104440_RS11905	COG1555	photosystem II stabilization
DSM104440_RS11915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104440_RS11920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DSM104440_RS11930	COG0284	orotidine-5'-phosphate decarboxylase activity
DSM104440_RS11935	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DSM104440_RS11960	COG0776	regulation of translation
DSM104440_RS11970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DSM104440_RS11975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DSM104440_RS11980	COG0287	Prephenate dehydrogenase
DSM104440_RS11985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM104440_RS11995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104440_RS12000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DSM104440_RS12015	COG0402	S-adenosylhomocysteine deaminase activity
DSM104440_RS12020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM104440_RS12045	COG1216	Glycosyl transferase, family 2
DSM104440_RS12045	COG0438	transferase activity, transferring glycosyl groups
DSM104440_RS12060	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DSM104440_RS12070	COG3629	intracellular signal transduction
DSM104440_RS12070	COG3903	Transcriptional regulator
DSM104440_RS12090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM104440_RS12105	COG2032	superoxide dismutase activity
DSM104440_RS12115	COG2864	formate dehydrogenase
DSM104440_RS12125	COG0437	4 iron, 4 sulfur cluster binding
DSM104440_RS12130	COG3383	formate dehydrogenase (NAD+) activity
DSM104440_RS12130	COG0243	molybdopterin cofactor binding
DSM104440_RS12160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSM104440_RS12165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DSM104440_RS12175	COG0746	molybdenum cofactor guanylyltransferase activity
DSM104440_RS12195	COG1309	transcriptional regulator
DSM104440_RS12220	COG0583	DNA-binding transcription factor activity
DSM104440_RS12225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSM104440_RS12235	COG0175	sulfate reduction
DSM104440_RS12240	COG0175	sulfate reduction
DSM104440_RS12245	COG2895	sulfate adenylyltransferase (ATP) activity
DSM104440_RS12255	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DSM104440_RS12265	COG4208	sulfate ABC transporter
DSM104440_RS12270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DSM104440_RS12295	COG4654	Cytochrome c, class I
DSM104440_RS12300	COG3005	denitrification pathway
DSM104440_RS12325	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSM104440_RS12335	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DSM104440_RS12340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DSM104440_RS12345	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DSM104440_RS12350	COG0167	dihydroorotate dehydrogenase activity
DSM104440_RS12355	COG0686	Belongs to the AlaDH PNT family
DSM104440_RS12360	COG2878	Part of a membrane complex involved in electron transport
DSM104440_RS12365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DSM104440_RS12395	COG1595	DNA-templated transcription, initiation
DSM104440_RS12400	COG5001	Diguanylate cyclase
DSM104440_RS12400	COG5002	protein histidine kinase activity
DSM104440_RS12405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DSM104440_RS12410	COG0328	RNA-DNA hybrid ribonuclease activity
DSM104440_RS12420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104440_RS12450	COG1388	LysM domain
DSM104440_RS12450	COG0741	lytic transglycosylase activity
DSM104440_RS12455	COG0339	signal peptide processing
DSM104440_RS12470	COG0601	transmembrane transport
DSM104440_RS12475	COG0747	negative chemotaxis
DSM104440_RS12480	COG4166	transmembrane transport
DSM104440_RS12495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104440_RS12510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM104440_RS12515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DSM104440_RS12520	COG0740	serine-type endopeptidase activity
DSM104440_RS12525	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSM104440_RS12540	COG1562	ergosterol biosynthetic process
DSM104440_RS12545	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DSM104440_RS12550	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS12565	COG0515	serine threonine protein kinase
DSM104440_RS12565	COG2815	serine threonine protein kinase
DSM104440_RS12575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DSM104440_RS12580	COG0305	Participates in initiation and elongation during chromosome replication
DSM104440_RS12585	COG0359	binds to the 23S rRNA
DSM104440_RS12590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DSM104440_RS12600	COG0360	Binds together with S18 to 16S ribosomal RNA
DSM104440_RS12655	COG0297	glycogen (starch) synthase activity
DSM104440_RS12660	COG1091	dTDP-4-dehydrorhamnose reductase activity
DSM104440_RS12675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSM104440_RS12710	COG0612	Peptidase, M16
DSM104440_RS12715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM104440_RS12720	COG0557	exoribonuclease II activity
DSM104440_RS12735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSM104440_RS12740	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DSM104440_RS12750	COG0330	HflC and HflK could
DSM104440_RS12755	COG0330	HflC and HflK could
DSM104440_RS12760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DSM104440_RS12765	COG1923	regulation of RNA biosynthetic process
DSM104440_RS12770	COG1160	GTP binding
DSM104440_RS12780	COG2976	Protein conserved in bacteria
DSM104440_RS12785	COG0124	histidyl-tRNA synthetase
DSM104440_RS12790	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DSM104440_RS12805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DSM104440_RS12810	COG0105	UTP biosynthetic process
DSM104440_RS12815	COG0037	tRNA processing
DSM104440_RS12820	COG0825	malonyl-CoA metabolic process
DSM104440_RS12825	COG2096	Adenosyltransferase
DSM104440_RS12845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DSM104440_RS12850	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DSM104440_RS12855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DSM104440_RS12860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DSM104440_RS12880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM104440_RS12900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM104440_RS12935	COG0312	modulator of DNA gyrase
DSM104440_RS12950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DSM104440_RS13025	COG1073	alpha beta
DSM104440_RS13025	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
DSM104440_RS13025	COG3064	Membrane
DSM104440_RS13115	COG0429	hydrolase of the alpha beta-hydrolase fold
DSM104440_RS13175	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS13190	COG0625	glutathione transferase activity
DSM104440_RS13215	COG0625	glutathione transferase activity
DSM104440_RS13250	COG2217	Heavy metal translocating P-type atpase
DSM104440_RS13255	COG1505	serine-type exopeptidase activity
DSM104440_RS13260	COG1132	(ABC) transporter
DSM104440_RS13290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DSM104440_RS13310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104440_RS13315	COG3647	Membrane
DSM104440_RS13320	COG1940	carbohydrate kinase activity
DSM104440_RS13340	COG0438	transferase activity, transferring glycosyl groups
DSM104440_RS13360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DSM104440_RS13365	COG3540	Alkaline phosphatase
DSM104440_RS13380	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS13420	COG3158	transport of potassium into the cell
DSM104440_RS13440	COG2135	peptidase activity
DSM104440_RS13450	COG0322	excinuclease ABC activity
DSM104440_RS13455	COG0583	DNA-binding transcription factor activity
DSM104440_RS13480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSM104440_RS13480	COG4651	solute:proton antiporter activity
DSM104440_RS13485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DSM104440_RS13510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104440_RS13520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM104440_RS13540	COG1278	Cold shock
DSM104440_RS13560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM104440_RS13575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM104440_RS13580	COG2755	lipolytic protein G-D-S-L family
DSM104440_RS13610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DSM104440_RS13615	COG0583	DNA-binding transcription factor activity
DSM104440_RS13620	COG1678	Uncharacterized ACR, COG1678
DSM104440_RS13625	COG2972	Histidine kinase
DSM104440_RS13640	COG1733	regulation of RNA biosynthetic process
DSM104440_RS13650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DSM104440_RS13650	COG2124	cytochrome p450
DSM104440_RS13665	COG3710	Transcriptional regulator
DSM104440_RS13665	COG0457	Tetratricopeptide repeat
DSM104440_RS13675	COG0431	NADPH-dependent FMN reductase
DSM104440_RS13710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM104440_RS13715	COG0765	amino acid transport
DSM104440_RS13720	COG0765	amino acid transport
DSM104440_RS13735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM104440_RS13750	COG0513	Belongs to the DEAD box helicase family
DSM104440_RS13760	COG0534	Mate efflux family protein
DSM104440_RS13770	COG0222	ribosome binding
DSM104440_RS13800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM104440_RS13810	COG1690	Belongs to the RtcB family
DSM104440_RS13815	COG3795	YCII-related domain
DSM104440_RS13830	COG1309	transcriptional regulator
DSM104440_RS13850	COG0625	glutathione transferase activity
DSM104440_RS13855	COG0165	Argininosuccinate lyase
DSM104440_RS13865	COG0583	DNA-binding transcription factor activity
DSM104440_RS13910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DSM104440_RS13910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM104440_RS13955	COG1538	Outer membrane efflux protein
DSM104440_RS13965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104440_RS13985	COG2205	protein histidine kinase activity
DSM104440_RS13990	COG0745	RESPONSE REGULATOR receiver
DSM104440_RS14005	COG0142	geranyltranstransferase activity
DSM104440_RS14010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM104440_RS14015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DSM104440_RS14020	COG1280	lysine exporter protein (LysE YggA)
DSM104440_RS14025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DSM104440_RS14055	COG0494	nUDIX hydrolase
DSM104440_RS14060	COG0442	prolyl-tRNA aminoacylation
DSM104440_RS14065	COG0741	lytic transglycosylase activity
DSM104440_RS14070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104440_RS14080	COG1959	2 iron, 2 sulfur cluster binding
DSM104440_RS14080	COG1295	ribonuclease BN
DSM104440_RS14095	COG0586	Pfam SNARE associated Golgi protein
DSM104440_RS14100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM104440_RS14105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM104440_RS14110	COG1862	Preprotein translocase
DSM104440_RS14115	COG0343	queuine tRNA-ribosyltransferase activity
DSM104440_RS14125	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DSM104440_RS14130	COG0205	6-phosphofructokinase activity
DSM104440_RS14135	COG0563	adenylate kinase activity
DSM104440_RS14140	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DSM104440_RS14145	COG2835	tetraacyldisaccharide 4'-kinase activity
DSM104440_RS14150	COG1663	tetraacyldisaccharide 4'-kinase activity
DSM104440_RS14165	COG1570	exodeoxyribonuclease VII activity
DSM104440_RS14170	COG3360	Dodecin
DSM104440_RS14175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DSM104440_RS14180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DSM104440_RS14190	COG0860	N-Acetylmuramoyl-L-alanine amidase
DSM104440_RS14195	COG0802	atpase or kinase
DSM104440_RS14200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DSM104440_RS14230	COG0277	FAD linked oxidase domain protein
DSM104440_RS14245	COG3735	TraB family
DSM104440_RS14255	COG2095	MarC family integral membrane protein
DSM104440_RS14260	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104440_RS14270	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DSM104440_RS14275	COG0148	phosphopyruvate hydratase activity
DSM104440_RS14310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM104440_RS14355	COG3201	nicotinamide mononucleotide transporter
DSM104440_RS14395	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DSM104440_RS14410	COG0004	ammonium transporteR
DSM104440_RS14425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DSM104440_RS14430	COG0504	CTP synthase activity
DSM104440_RS14445	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DSM104440_RS14450	COG0235	Class ii aldolase
DSM104440_RS14470	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DSM104440_RS14505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104440_RS14520	COG0251	oxidation-reduction process
DSM104440_RS14530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM104440_RS14535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM104440_RS14550	COG0166	Belongs to the GPI family
DSM104440_RS14600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DSM104440_RS14610	COG1007	ATP synthesis coupled electron transport
DSM104440_RS14625	COG0713	ATP synthesis coupled electron transport
DSM104440_RS14630	COG0839	Belongs to the complex I subunit 6 family
DSM104440_RS14635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104440_RS14640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DSM104440_RS14645	COG1034	ATP synthesis coupled electron transport
DSM104440_RS14650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DSM104440_RS14665	COG0649	NAD binding
DSM104440_RS14670	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104440_RS14675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104440_RS14680	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104440_RS14695	COG0149	triose-phosphate isomerase activity
DSM104440_RS14715	COG0798	PFAM Bile acid sodium symporter
DSM104440_RS14725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DSM104440_RS14730	COG0581	inorganic phosphate transmembrane transporter activity
DSM104440_RS14735	COG0573	inorganic phosphate transmembrane transporter activity
DSM104440_RS14740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DSM104440_RS14745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSM104440_RS14750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DSM104440_RS14755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM104440_RS14760	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DSM104440_RS14770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSM104440_RS14775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSM104440_RS14780	COG0505	Belongs to the CarA family
DSM104440_RS14785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DSM104440_RS14790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DSM104440_RS14795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM104440_RS14800	COG0735	belongs to the Fur family
DSM104440_RS14815	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DSM104440_RS14815	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DSM104440_RS14815	COG0506	proline dehydrogenase activity
DSM104440_RS14820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104440_RS14825	COG0783	Belongs to the Dps family
DSM104440_RS14845	COG1741	Belongs to the pirin family
DSM104440_RS14850	COG0583	DNA-binding transcription factor activity
DSM104440_RS14855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104440_RS14905	COG0515	serine threonine protein kinase
DSM104440_RS14930	COG0473	3-isopropylmalate dehydrogenase activity
DSM104440_RS14935	COG0596	Alpha beta hydrolase
DSM104440_RS14950	COG0515	serine threonine protein kinase
DSM104440_RS14960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DSM104440_RS14990	COG1881	PFAM PEBP family protein
DSM104440_RS14995	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSM104440_RS15000	COG0405	Gamma-glutamyltransferase
DSM104440_RS15020	COG5001	Diguanylate cyclase
DSM104440_RS15020	COG3300	MHYT domain
DSM104440_RS15030	COG0747	negative chemotaxis
DSM104440_RS15060	COG1733	regulation of RNA biosynthetic process
DSM104440_RS15065	COG3186	Phenylalanine-4-hydroxylase
DSM104440_RS15075	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DSM104440_RS15100	COG0747	negative chemotaxis
DSM104440_RS15105	COG4166	transmembrane transport
DSM104440_RS15110	COG0601	transmembrane transport
DSM104440_RS15115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM104440_RS15130	COG0444	Belongs to the ABC transporter superfamily
DSM104440_RS15135	COG4608	Belongs to the ABC transporter superfamily
DSM104440_RS15150	COG1696	Membrane protein involved in D-alanine export
DSM104440_RS15165	COG0436	Aminotransferase
DSM104440_RS15170	COG1643	Atp-dependent helicase
DSM104440_RS15200	COG0625	glutathione transferase activity
DSM104440_RS15205	COG2084	Dehydrogenase
DSM104440_RS15230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM104440_RS15240	COG1556	Lactate utilization protein
DSM104440_RS15250	COG0247	lactate metabolic process
DSM104440_RS15255	COG0739	heme binding
DSM104440_RS15255	COG0741	lytic transglycosylase activity
DSM104440_RS15255	COG1196	nuclear chromosome segregation
DSM104440_RS15260	COG1686	Belongs to the peptidase S11 family
DSM104440_RS15275	COG5265	(ABC) transporter
DSM104440_RS15280	COG0662	Cupin 2, conserved barrel domain protein
DSM104440_RS15315	COG4771	TonB-dependent receptor
DSM104440_RS15330	COG3622	Belongs to the hyi family
DSM104440_RS15335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104440_RS15375	COG3383	formate dehydrogenase (NAD+) activity
DSM104440_RS15385	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DSM104440_RS15395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DSM104440_RS15400	COG0045	succinate-CoA ligase (ADP-forming) activity
DSM104440_RS15410	COG2815	serine threonine protein kinase
DSM104440_RS15410	COG0515	serine threonine protein kinase
DSM104440_RS15430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM104440_RS15435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104440_RS15470	COG0861	Integral membrane protein TerC family
DSM104440_RS15485	COG0617	tRNA 3'-terminal CCA addition
DSM104440_RS15500	COG2358	TRAP transporter, solute receptor (TAXI family
DSM104440_RS15505	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DSM104440_RS15510	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DSM104440_RS15570	COG0037	tRNA processing
DSM104440_RS15585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM104440_RS15620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DSM104440_RS15630	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DSM104440_RS15635	COG0625	glutathione transferase activity
DSM104440_RS15690	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DSM104440_RS15710	COG1560	Kdo2-lipid A biosynthetic process
DSM104440_RS15715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DSM104440_RS15725	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DSM104440_RS15730	COG0523	cobalamin synthesis protein
DSM104440_RS15735	COG0523	cobalamin synthesis protein
DSM104440_RS15745	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DSM104440_RS15750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DSM104440_RS15770	COG3220	belongs to the UPF0276 family
DSM104440_RS15785	COG0071	Belongs to the small heat shock protein (HSP20) family
DSM104440_RS15790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSM104440_RS15800	COG3568	Endonuclease Exonuclease Phosphatase
DSM104440_RS15805	COG0494	nUDIX hydrolase
DSM104440_RS15810	COG1446	asparaginase
DSM104440_RS15815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DSM104440_RS15830	COG0501	Belongs to the peptidase M48B family
DSM104440_RS15835	COG0629	single-stranded DNA binding
DSM104440_RS15840	COG2814	Major facilitator Superfamily
DSM104440_RS15855	COG0203	ribosomal protein L17
DSM104440_RS15860	COG0202	RNA polymerase activity
DSM104440_RS15865	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DSM104440_RS15870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DSM104440_RS15875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DSM104440_RS15880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DSM104440_RS15885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DSM104440_RS15890	COG0201	protein transport
DSM104440_RS15895	COG0200	Binds to the 23S rRNA
DSM104440_RS15900	COG1841	ribosomal large subunit assembly
DSM104440_RS15905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DSM104440_RS15910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DSM104440_RS15915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DSM104440_RS15930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DSM104440_RS15935	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DSM104440_RS15940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DSM104440_RS15945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DSM104440_RS15950	COG0255	Belongs to the universal ribosomal protein uL29 family
DSM104440_RS15955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DSM104440_RS15960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DSM104440_RS15965	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DSM104440_RS15970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DSM104440_RS15975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DSM104440_RS15980	COG0089	rRNA binding
DSM104440_RS15985	COG0088	Forms part of the polypeptide exit tunnel
DSM104440_RS15990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DSM104440_RS15995	COG0051	transcription antitermination factor activity, RNA binding
DSM104440_RS16005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSM104440_RS16010	COG0049	tRNA binding
DSM104440_RS16015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DSM104440_RS16020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DSM104440_RS16025	COG0085	RNA polymerase activity
DSM104440_RS16030	COG0222	ribosome binding
DSM104440_RS16035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DSM104440_RS16040	COG0081	regulation of translation
DSM104440_RS16045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DSM104440_RS16055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DSM104440_RS16090	COG2969	positive regulation of protein catabolic process
DSM104440_RS16095	COG0625	glutathione transferase activity
DSM104440_RS16100	COG2857	Cytochrome c1
DSM104440_RS16105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DSM104440_RS16110	COG0723	plastoquinol--plastocyanin reductase activity
DSM104440_RS16115	COG1970	mechanosensitive ion channel activity
DSM104440_RS16125	COG0805	protein transport
DSM104440_RS16130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM104440_RS16135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM104440_RS16145	COG0140	phosphoribosyl-ATP diphosphatase activity
DSM104440_RS16150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DSM104440_RS16160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DSM104440_RS16165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DSM104440_RS16170	COG0131	Imidazoleglycerol-phosphate dehydratase
DSM104440_RS16175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM104440_RS16180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSM104440_RS16185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DSM104440_RS16190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DSM104440_RS16195	COG0271	Belongs to the BolA IbaG family
DSM104440_RS16200	COG0842	Transport permease protein
DSM104440_RS16205	COG1131	(ABC) transporter
DSM104440_RS16215	COG2854	intermembrane phospholipid transfer
DSM104440_RS16220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DSM104440_RS16225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DSM104440_RS16230	COG1127	ABC transporter
DSM104440_RS16240	COG3267	Type II secretory pathway component ExeA
DSM104440_RS16240	COG3409	Peptidoglycan-binding domain 1 protein
DSM104440_RS16255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSM104440_RS16290	COG1469	GTP cyclohydrolase I activity
DSM104440_RS16300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DSM104440_RS16315	COG0137	argininosuccinate synthase activity
DSM104440_RS16320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DSM104440_RS16325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSM104440_RS16330	COG0268	Binds directly to 16S ribosomal RNA
DSM104440_RS16335	COG0728	peptidoglycan biosynthetic process
DSM104440_RS16340	COG0196	riboflavin kinase activity
DSM104440_RS16345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DSM104440_RS16350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DSM104440_RS16355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DSM104440_RS16400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM104440_RS16405	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DSM104440_RS16420	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DSM104440_RS16425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSM104440_RS16425	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DSM104440_RS16430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DSM104440_RS16435	COG3766	membrane
DSM104440_RS16440	COG0754	glutathionylspermidine amidase activity
DSM104440_RS16450	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DSM104440_RS16455	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DSM104440_RS16460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DSM104440_RS16470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DSM104440_RS16485	COG0126	phosphoglycerate kinase activity
DSM104440_RS16490	COG0469	pyruvate kinase activity
DSM104440_RS16505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DSM104440_RS16520	COG0730	response to heat
DSM104440_RS16540	COG4206	TonB-dependent receptor
DSM104440_RS16545	COG3510	cephalosporin hydroxylase
DSM104440_RS16570	COG0859	PFAM glycosyl transferase family 9
DSM104440_RS16575	COG0438	transferase activity, transferring glycosyl groups
DSM104440_RS16580	COG1132	(ABC) transporter
DSM104440_RS16585	COG0438	transferase activity, transferring glycosyl groups
DSM104440_RS16590	COG0859	PFAM glycosyl transferase family 9
DSM104440_RS16635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104440_RS16655	COG1450	Type ii and iii secretion system protein
DSM104440_RS16670	COG3166	PFAM Fimbrial assembly family protein
DSM104440_RS16675	COG3156	type II secretion system protein K
DSM104440_RS16685	COG2165	general secretion pathway protein
DSM104440_RS16690	COG4970	Tfp pilus assembly protein FimT
DSM104440_RS16695	COG2165	general secretion pathway protein
DSM104440_RS16700	COG1459	type II secretion system
DSM104440_RS16705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSM104440_RS16710	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DSM104440_RS16710	COG0662	Cupin 2, conserved barrel domain protein
DSM104440_RS16720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104440_RS16750	COG2264	protein methyltransferase activity
DSM104440_RS16755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM104440_RS16770	COG1215	transferase activity, transferring glycosyl groups
DSM104440_RS16775	COG0463	Glycosyl transferase, family 2
DSM104440_RS16780	COG0367	asparagine synthase
DSM104440_RS16790	COG2226	methyltransferase
DSM104440_RS16830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DSM104440_RS16845	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS16870	COG0463	Glycosyl transferase, family 2
DSM104440_RS16955	COG0438	transferase activity, transferring glycosyl groups
DSM104440_RS16955	COG1216	Glycosyl transferase, family 2
DSM104440_RS16970	COG0438	transferase activity, transferring glycosyl groups
DSM104440_RS16980	COG0004	ammonium transporteR
DSM104440_RS16985	COG0347	Belongs to the P(II) protein family
DSM104440_RS17005	COG0606	chelatase, subunit chli
DSM104440_RS17010	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DSM104440_RS17025	COG2814	Major facilitator Superfamily
DSM104440_RS17030	COG2814	Major facilitator Superfamily
DSM104440_RS17040	COG1473	amidohydrolase
DSM104440_RS17055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104440_RS17070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104440_RS17075	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM104440_RS17110	COG0625	glutathione transferase activity
DSM104440_RS17125	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS17140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DSM104440_RS17145	COG0142	geranyltranstransferase activity
DSM104440_RS17150	COG1722	exodeoxyribonuclease VII activity
DSM104440_RS17195	COG1450	Type ii and iii secretion system protein
DSM104440_RS17250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104440_RS17275	COG1649	PFAM Uncharacterised BCR, COG1649
DSM104440_RS17305	COG0745	RESPONSE REGULATOR receiver
DSM104440_RS17325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DSM104440_RS17340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM104440_RS17345	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DSM104440_RS17350	COG1053	succinate dehydrogenase
DSM104440_RS17415	COG2855	membrane
DSM104440_RS17420	COG2721	sulfolactate sulfo-lyase activity
DSM104440_RS17430	COG1609	Transcriptional regulator
DSM104440_RS17440	COG2321	neutral zinc metallopeptidase
DSM104440_RS17445	COG0335	large ribosomal subunit rRNA binding
DSM104440_RS17450	COG0336	Belongs to the RNA methyltransferase TrmD family
DSM104440_RS17455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DSM104440_RS17460	COG0228	four-way junction DNA binding
DSM104440_RS17465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM104440_RS17475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DSM104440_RS17485	COG4536	flavin adenine dinucleotide binding
DSM104440_RS17515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM104440_RS17520	COG0288	reversible hydration of carbon dioxide
DSM104440_RS17535	COG3483	tryptophan 2,3-dioxygenase activity
DSM104440_RS17565	COG2208	phosphoserine phosphatase activity
DSM104440_RS17570	COG1234	tRNA 3'-trailer cleavage
DSM104440_RS17575	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM104440_RS17580	COG0745	RESPONSE REGULATOR receiver
DSM104440_RS17585	COG2205	protein histidine kinase activity
DSM104440_RS17605	COG1609	Transcriptional regulator
DSM104440_RS17620	COG3386	PFAM SMP-30 Gluconolaconase
DSM104440_RS17625	COG3836	Belongs to the HpcH HpaI aldolase family
DSM104440_RS17635	COG0842	Transport permease protein
DSM104440_RS17640	COG1131	(ABC) transporter
DSM104440_RS17650	COG1752	Esterase of the alpha-beta hydrolase superfamily
DSM104440_RS17670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM104440_RS17675	COG2081	HI0933 family
DSM104440_RS17680	COG0667	Aldo Keto reductase
DSM104440_RS17685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DSM104440_RS17710	COG0789	Transcriptional regulator
DSM104440_RS17735	COG1131	(ABC) transporter
DSM104440_RS17760	COG2312	Erythromycin esterase
DSM104440_RS17840	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS17910	COG0459	protein refolding
DSM104440_RS17915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DSM104440_RS17945	COG2823	Periplasmic or secreted lipoprotein
DSM104440_RS17975	COG0564	pseudouridine synthase activity
DSM104440_RS17990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DSM104440_RS18000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DSM104440_RS18005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DSM104440_RS18010	COG2188	Transcriptional regulator
DSM104440_RS18020	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DSM104440_RS18025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM104440_RS18025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM104440_RS18030	COG1263	PTS System
DSM104440_RS18030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DSM104440_RS18030	COG2190	(PTS) system
DSM104440_RS18035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM104440_RS18055	COG2027	D-alanyl-D-alanine carboxypeptidase
DSM104440_RS18080	COG4941	Belongs to the sigma-70 factor family
DSM104440_RS18085	COG3795	YCII-related domain
DSM104440_RS18100	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DSM104440_RS18140	COG1960	acyl-CoA dehydrogenase activity
DSM104440_RS18150	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DSM104440_RS18160	COG1981	membrane
DSM104440_RS18165	COG4232	protein-disulfide reductase activity
DSM104440_RS18200	COG2945	thiolester hydrolase activity
DSM104440_RS18225	COG2972	Histidine kinase
DSM104440_RS18265	COG3842	ATPase activity
DSM104440_RS18275	COG1175	transmembrane transport
DSM104440_RS18280	COG0395	ABC-type sugar transport system, permease component
DSM104440_RS18300	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104440_RS18305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DSM104440_RS18320	COG0515	serine threonine protein kinase
DSM104440_RS18330	COG2814	Major facilitator Superfamily
DSM104440_RS18345	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DSM104440_RS18350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104440_RS18385	COG2226	methyltransferase
DSM104440_RS18410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM104440_RS18415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM104440_RS18425	COG3064	Membrane
DSM104440_RS18430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM104440_RS18435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM104440_RS18435	COG2813	Specifically methylates the guanine in position
DSM104440_RS18445	COG2223	nitrite transmembrane transporter activity
DSM104440_RS18450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104440_RS18460	COG0488	(ABC) transporter
DSM104440_RS18465	COG0708	Exodeoxyribonuclease III
DSM104440_RS18470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DSM104440_RS18480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM104440_RS18485	COG0154	amidase activity
DSM104440_RS18490	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM104440_RS18495	COG1077	Cell shape determining protein MreB Mrl
DSM104440_RS18500	COG1792	Involved in formation and maintenance of cell shape
DSM104440_RS18505	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DSM104440_RS18510	COG0768	penicillin binding
DSM104440_RS18515	COG0772	Belongs to the SEDS family
DSM104440_RS18525	COG1686	Belongs to the peptidase S11 family
DSM104440_RS18530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM104440_RS18535	COG2921	Belongs to the UPF0250 family
DSM104440_RS18540	COG0321	lipoyl(octanoyl) transferase activity
DSM104440_RS18565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DSM104440_RS18575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DSM104440_RS18595	COG3275	phosphorelay sensor kinase activity
DSM104440_RS18600	COG0165	Argininosuccinate lyase
DSM104440_RS18630	COG2239	Acts as a magnesium transporter
DSM104440_RS18635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DSM104440_RS18640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DSM104440_RS18645	COG0174	glutamine synthetase
DSM104440_RS18655	COG3852	Histidine kinase
DSM104440_RS18660	COG2204	response regulator
DSM104440_RS18680	COG0339	signal peptide processing
DSM104440_RS18690	COG0540	Belongs to the ATCase OTCase family
DSM104440_RS18700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DSM104440_RS18705	COG1678	Uncharacterized ACR, COG1678
DSM104440_RS18730	COG3150	esterase
DSM104440_RS18740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSM104440_RS18755	COG0189	ligase activity
DSM104440_RS18775	COG1238	metal cluster binding
DSM104440_RS18780	COG0181	hydroxymethylbilane synthase activity
DSM104440_RS18785	COG1587	Uroporphyrinogen-III synthase
DSM104440_RS18815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104440_RS18820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DSM104440_RS18825	COG0511	ligase activity, forming carbon-carbon bonds
DSM104440_RS18830	COG0439	Biotin carboxylase
DSM104440_RS18835	COG2264	protein methyltransferase activity
DSM104440_RS18850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM104440_RS18870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DSM104440_RS18875	COG3245	cytochrome
DSM104440_RS18895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM104440_RS18915	COG0067	glutamate synthase
DSM104440_RS18915	COG0070	glutamate synthase
DSM104440_RS18915	COG0069	glutamate synthase activity
DSM104440_RS18935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DSM104440_RS18945	COG0018	arginyl-trna synthetase
DSM104440_RS18955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSM104440_RS18960	COG0300	oxidoreductase activity
DSM104440_RS18965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM104440_RS18975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM104440_RS18985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM104440_RS19000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104440_RS19005	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM104440_RS19020	COG2271	Major facilitator Superfamily
DSM104440_RS19050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSM104440_RS19055	COG2323	membrane
DSM104440_RS19060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DSM104440_RS19080	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DSM104440_RS19085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104440_RS19090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM104440_RS19095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DSM104440_RS19115	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM104440_RS19120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DSM104440_RS19130	COG0356	it plays a direct role in the translocation of protons across the membrane
DSM104440_RS19140	COG1475	DNA binding
DSM104440_RS19145	COG1192	Involved in chromosome partitioning
DSM104440_RS19150	COG0357	Ribosomal RNA small subunit methyltransferase G
DSM104440_RS19155	COG0445	tRNA wobble uridine modification
DSM104440_RS19170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DSM104440_RS19175	COG0706	membrane insertase activity
DSM104440_RS19180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DSM104440_RS19185	COG0594	ribonuclease P activity
DSM104440_RS19190	COG0230	Belongs to the bacterial ribosomal protein bL34 family