locus-tag	class	description
H9L18_RS00165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9L18_RS00170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9L18_RS00175	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9L18_RS00185	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H9L18_RS00190	COG0037	tRNA processing
H9L18_RS00195	COG1098	S1 RNA binding domain
H9L18_RS00205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H9L18_RS00210	COG2244	polysaccharide biosynthetic process
H9L18_RS00215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9L18_RS00220	COG0193	aminoacyl-tRNA hydrolase activity
H9L18_RS00225	COG0039	L-malate dehydrogenase activity
H9L18_RS00230	COG0726	polysaccharide deacetylase
H9L18_RS00280	COG1309	transcriptional regulator
H9L18_RS00305	COG1605	Chorismate mutase
H9L18_RS00305	COG0077	Prephenate dehydratase
H9L18_RS00310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9L18_RS00315	COG0765	amino acid transport
H9L18_RS00320	COG1126	abc transporter atp-binding protein
H9L18_RS00335	COG0840	transmembrane signaling receptor activity
H9L18_RS00380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L18_RS00385	COG1187	pseudouridine synthase activity
H9L18_RS00390	COG2244	polysaccharide biosynthetic process
H9L18_RS00395	COG0495	leucyl-tRNA aminoacylation
H9L18_RS00400	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9L18_RS00400	COG1388	LysM domain
H9L18_RS00415	COG0671	phosphoesterase, PA-phosphatase related
H9L18_RS00420	COG1242	4 iron, 4 sulfur cluster binding
H9L18_RS00425	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H9L18_RS00435	COG1395	domain, Protein
H9L18_RS00445	COG3620	sequence-specific DNA binding
H9L18_RS00480	COG1686	Belongs to the peptidase S11 family
H9L18_RS00490	COG0477	Major facilitator Superfamily
H9L18_RS00495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9L18_RS00520	COG0693	protein deglycase activity
H9L18_RS00525	COG0813	purine-nucleoside phosphorylase activity
H9L18_RS00530	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H9L18_RS00535	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H9L18_RS00540	COG1079	Belongs to the binding-protein-dependent transport system permease family
H9L18_RS00545	COG4603	Belongs to the binding-protein-dependent transport system permease family
H9L18_RS00550	COG3845	ABC transporter
H9L18_RS00555	COG1744	ABC transporter substrate-binding protein PnrA-like
H9L18_RS00565	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H9L18_RS00570	COG1609	Transcriptional regulator
H9L18_RS00575	COG2207	Transcriptional regulator
H9L18_RS00590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H9L18_RS00605	COG1349	DNA-binding transcription factor activity
H9L18_RS00610	COG1979	alcohol dehydrogenase
H9L18_RS00640	COG0142	geranyltranstransferase activity
H9L18_RS00645	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
H9L18_RS00650	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
H9L18_RS00655	COG1120	ATPase activity
H9L18_RS00660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L18_RS00670	COG0488	(ABC) transporter
H9L18_RS00685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9L18_RS00690	COG0305	Participates in initiation and elongation during chromosome replication
H9L18_RS00695	COG0359	binds to the 23S rRNA
H9L18_RS00700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9L18_RS00705	COG0629	single-stranded DNA binding
H9L18_RS00710	COG0360	Binds together with S18 to 16S ribosomal RNA
H9L18_RS00720	COG0187	DNA topoisomerase II activity
H9L18_RS00725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9L18_RS00735	COG0592	DNA-directed DNA polymerase activity
H9L18_RS00745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H9L18_RS00750	COG0594	ribonuclease P activity
H9L18_RS00755	COG0706	membrane insertase activity
H9L18_RS00765	COG0018	arginyl-trna synthetase
H9L18_RS00775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9L18_RS00780	COG0445	tRNA wobble uridine modification
H9L18_RS00815	COG0357	Ribosomal RNA small subunit methyltransferase G
H9L18_RS00820	COG1192	Involved in chromosome partitioning
H9L18_RS00825	COG1475	DNA binding
H9L18_RS00830	COG4481	Protein conserved in bacteria
H9L18_RS00835	COG0012	GTP binding
H9L18_RS00845	COG0517	IMP dehydrogenase activity
H9L18_RS00845	COG0516	GMP reductase activity
H9L18_RS00850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9L18_RS01025	COG1114	Component of the transport system for branched-chain amino acids
H9L18_RS01030	COG0588	phosphoglycerate mutase activity
H9L18_RS01035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H9L18_RS01040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9L18_RS01045	COG0049	tRNA binding
H9L18_RS01050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9L18_RS01055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9L18_RS01065	COG0051	transcription antitermination factor activity, RNA binding
H9L18_RS01070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9L18_RS01075	COG0088	Forms part of the polypeptide exit tunnel
H9L18_RS01080	COG0089	rRNA binding
H9L18_RS01085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9L18_RS01095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9L18_RS01100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9L18_RS01105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9L18_RS01110	COG0255	Belongs to the universal ribosomal protein uL29 family
H9L18_RS01115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9L18_RS01120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9L18_RS01125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9L18_RS01130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9L18_RS01135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9L18_RS01140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9L18_RS01145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9L18_RS01150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9L18_RS01155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9L18_RS01160	COG1841	ribosomal large subunit assembly
H9L18_RS01165	COG0200	Binds to the 23S rRNA
H9L18_RS01175	COG0563	adenylate kinase activity
H9L18_RS01180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9L18_RS01185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9L18_RS01190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9L18_RS01195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9L18_RS01200	COG0202	RNA polymerase activity
H9L18_RS01205	COG0203	ribosomal protein L17
H9L18_RS01210	COG1122	ATPase activity
H9L18_RS01215	COG1122	ATPase activity
H9L18_RS01225	COG0101	tRNA pseudouridine synthase activity
H9L18_RS01230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9L18_RS01235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9L18_RS01240	COG0582	viral genome integration into host DNA
H9L18_RS01255	COG0582	viral genome integration into host DNA
H9L18_RS01315	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H9L18_RS01340	COG1674	ftsk spoiiie
H9L18_RS01390	COG0582	viral genome integration into host DNA
H9L18_RS01405	COG3328	transposase activity
H9L18_RS01420	COG0640	Transcriptional regulator
H9L18_RS01430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L18_RS01440	COG1132	(ABC) transporter
H9L18_RS01455	COG1285	pathogenesis
H9L18_RS01480	COG0494	nUDIX hydrolase
H9L18_RS01490	COG1683	Conserved Protein
H9L18_RS01500	COG1846	Transcriptional regulator
H9L18_RS01505	COG0346	lactoylglutathione lyase activity
H9L18_RS01510	COG0346	lactoylglutathione lyase activity
H9L18_RS01515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H9L18_RS01520	COG0400	carboxylic ester hydrolase activity
H9L18_RS01535	COG0584	glycerophosphoryl diester phosphodiesterase
H9L18_RS01540	COG0038	chloride channel
H9L18_RS01545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9L18_RS01555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L18_RS01560	COG2070	2-Nitropropane dioxygenase
H9L18_RS01570	COG0431	NADPH-dependent FMN reductase
H9L18_RS01605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9L18_RS01615	COG0110	maltose O-acetyltransferase activity
H9L18_RS01625	COG1349	DNA-binding transcription factor activity
H9L18_RS01640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L18_RS01645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9L18_RS01655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9L18_RS01685	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L18_RS01690	COG1438	arginine binding
H9L18_RS01710	COG0564	pseudouridine synthase activity
H9L18_RS01715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L18_RS01720	COG3679	Belongs to the UPF0342 family
H9L18_RS01725	COG0420	3'-5' exonuclease activity
H9L18_RS01730	COG4717	serine-type aminopeptidase activity
H9L18_RS01735	COG3481	metal-dependent phosphohydrolase, HD sub domain
H9L18_RS01745	COG3764	Sortase (surface protein transpeptidase)
H9L18_RS01755	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L18_RS01760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L18_RS01770	COG0736	holo-[acyl-carrier-protein] synthase activity
H9L18_RS01790	COG1561	YicC-like family, N-terminal region
H9L18_RS01795	COG0194	GDP metabolic process
H9L18_RS01800	COG1758	RNA polymerase activity
H9L18_RS01810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9L18_RS01815	COG0242	peptide deformylase activity
H9L18_RS01820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9L18_RS01825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L18_RS01825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9L18_RS01835	COG2815	serine threonine protein kinase
H9L18_RS01835	COG0515	serine threonine protein kinase
H9L18_RS01840	COG1162	GTPase activity
H9L18_RS01845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9L18_RS01850	COG1564	THIamine pyrophosphokinase
H9L18_RS01855	COG3620	sequence-specific DNA binding
H9L18_RS01885	COG1175	transmembrane transport
H9L18_RS01890	COG0395	ABC-type sugar transport system, permease component
H9L18_RS01895	COG0673	inositol 2-dehydrogenase activity
H9L18_RS01905	COG0673	inositol 2-dehydrogenase activity
H9L18_RS01930	COG1132	(ABC) transporter
H9L18_RS01950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9L18_RS01960	COG1461	Dihydroxyacetone kinase
H9L18_RS01965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9L18_RS01970	COG0416	fatty acid biosynthetic process
H9L18_RS01975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L18_RS01985	COG4608	Belongs to the ABC transporter superfamily
H9L18_RS01990	COG0601	transmembrane transport
H9L18_RS01995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L18_RS02005	COG0571	ribonuclease III activity
H9L18_RS02010	COG1196	nuclear chromosome segregation
H9L18_RS02015	COG0561	phosphatase activity
H9L18_RS02020	COG0552	protein localization to endoplasmic reticulum
H9L18_RS02025	COG1349	DNA-binding transcription factor activity
H9L18_RS02030	COG1105	Belongs to the carbohydrate kinase PfkB family
H9L18_RS02035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L18_RS02035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L18_RS02035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L18_RS02040	COG2918	glutathione biosynthetic process
H9L18_RS02040	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L18_RS02060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L18_RS02065	COG4605	iron ion homeostasis
H9L18_RS02070	COG4604	ABC transporter, ATP-binding protein
H9L18_RS02075	COG4607	ABC-type enterochelin transport system periplasmic component
H9L18_RS02080	COG2971	BadF BadG BcrA BcrD
H9L18_RS02085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9L18_RS02090	COG1447	Phosphotransferase system cellobiose-specific component IIA
H9L18_RS02100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L18_RS02115	COG3876	Protein conserved in bacteria
H9L18_RS02125	COG1737	Transcriptional regulator
H9L18_RS02135	COG0415	Belongs to the DNA photolyase family
H9L18_RS02140	COG1418	mRNA catabolic process
H9L18_RS02165	COG3708	Transcriptional regulator
H9L18_RS02165	COG2207	Transcriptional regulator
H9L18_RS02175	COG1914	H( )-stimulated, divalent metal cation uptake system
H9L18_RS02185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L18_RS02185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L18_RS02190	COG0084	hydrolase, TatD family'
H9L18_RS02195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H9L18_RS02200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9L18_RS02210	COG3842	ATPase activity
H9L18_RS02215	COG1803	Methylglyoxal synthase
H9L18_RS02220	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H9L18_RS02225	COG0300	oxidoreductase activity
H9L18_RS02230	COG0789	Transcriptional regulator
H9L18_RS02235	COG1011	Hydrolase
H9L18_RS02245	COG1132	(ABC) transporter
H9L18_RS02250	COG1132	(ABC) transporter
H9L18_RS02260	COG3584	3D domain protein
H9L18_RS02280	COG1309	transcriptional regulator
H9L18_RS02290	COG3859	Proton-coupled thiamine transporter YuaJ
H9L18_RS02295	COG4684	Psort location CytoplasmicMembrane, score
H9L18_RS02300	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H9L18_RS02315	COG1692	metallophosphoesterase
H9L18_RS02320	COG4550	Control of competence regulator ComK, YlbF/YmcA
H9L18_RS02325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9L18_RS02330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9L18_RS02335	COG0424	maF-like protein
H9L18_RS02340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L18_RS02350	COG0632	four-way junction helicase activity
H9L18_RS02355	COG2255	four-way junction helicase activity
H9L18_RS02360	COG2226	methyltransferase
H9L18_RS02370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9L18_RS02375	COG0343	queuine tRNA-ribosyltransferase activity
H9L18_RS02390	COG1012	belongs to the aldehyde dehydrogenase family
H9L18_RS02390	COG1454	alcohol dehydrogenase
H9L18_RS02425	COG0217	transcriptional regulatory protein
H9L18_RS02435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9L18_RS02470	COG0827	DNA restriction-modification system
H9L18_RS02475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9L18_RS02500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9L18_RS02510	COG2264	protein methyltransferase activity
H9L18_RS02515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9L18_RS02520	COG2357	RelA SpoT domain protein
H9L18_RS02535	COG0640	Transcriptional regulator
H9L18_RS02540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9L18_RS02545	COG1490	D-aminoacyl-tRNA deacylase activity
H9L18_RS02555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9L18_RS02560	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9L18_RS02565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9L18_RS02570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L18_RS02580	COG2827	Endonuclease containing a URI domain
H9L18_RS02585	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9L18_RS02590	COG0204	Acyl-transferase
H9L18_RS02595	COG0384	phenazine biosynthesis protein PhzF
H9L18_RS02600	COG1454	alcohol dehydrogenase
H9L18_RS02605	COG0135	phosphoribosylanthranilate isomerase activity
H9L18_RS02610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L18_RS02615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L18_RS02615	COG1522	sequence-specific DNA binding
H9L18_RS02625	COG1131	(ABC) transporter
H9L18_RS02640	COG0420	3'-5' exonuclease activity
H9L18_RS02645	COG0419	ATPase involved in DNA repair
H9L18_RS02660	COG1132	(ABC) transporter
H9L18_RS02665	COG4720	Psort location CytoplasmicMembrane, score
H9L18_RS02670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9L18_RS02680	COG2814	Major facilitator Superfamily
H9L18_RS02685	COG4109	DRTGG domain
H9L18_RS02690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H9L18_RS02700	COG2197	response regulator
H9L18_RS02705	COG2972	Histidine kinase
H9L18_RS02710	COG1053	succinate dehydrogenase
H9L18_RS02710	COG3976	FMN-binding domain protein
H9L18_RS02725	COG3328	transposase activity
H9L18_RS02735	COG2323	membrane
H9L18_RS02740	COG4886	Leucine-rich repeat (LRR) protein
H9L18_RS02740	COG4932	domain protein
H9L18_RS02800	COG0459	protein refolding
H9L18_RS02805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9L18_RS02815	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H9L18_RS02820	COG0488	(ABC) transporter
H9L18_RS02845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9L18_RS02855	COG1164	Oligoendopeptidase f
H9L18_RS02865	COG4116	CYTH
H9L18_RS02870	COG2357	RelA SpoT domain protein
H9L18_RS02875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9L18_RS02885	COG2239	Acts as a magnesium transporter
H9L18_RS02895	COG3142	Participates in the control of copper homeostasis
H9L18_RS02905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9L18_RS02910	COG0406	alpha-ribazole phosphatase activity
H9L18_RS02915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9L18_RS02920	COG1597	lipid kinase activity
H9L18_RS02925	COG0431	NADPH-dependent FMN reductase
H9L18_RS02930	COG0456	acetyltransferase
H9L18_RS02945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L18_RS02955	COG0250	Participates in transcription elongation, termination and antitermination
H9L18_RS02965	COG1757	Na H antiporter
H9L18_RS02980	COG1760	l-serine dehydratase
H9L18_RS02985	COG1760	l-serine dehydratase
H9L18_RS02990	COG1546	Belongs to the CinA family
H9L18_RS02990	COG1058	Belongs to the CinA family
H9L18_RS02995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9L18_RS03000	COG1418	mRNA catabolic process
H9L18_RS03005	COG1396	sequence-specific DNA binding
H9L18_RS03010	COG1132	(ABC) transporter
H9L18_RS03020	COG5002	protein histidine kinase activity
H9L18_RS03020	COG3850	Histidine kinase
H9L18_RS03025	COG1917	Cupin 2, conserved barrel domain protein
H9L18_RS03025	COG2207	Transcriptional regulator
H9L18_RS03030	COG0673	inositol 2-dehydrogenase activity
H9L18_RS03045	COG0673	inositol 2-dehydrogenase activity
H9L18_RS03050	COG2217	Heavy metal translocating P-type atpase
H9L18_RS03060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9L18_RS03065	COG0081	regulation of translation
H9L18_RS03070	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9L18_RS03075	COG0222	ribosome binding
H9L18_RS03080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9L18_RS03085	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
H9L18_RS03090	COG4122	O-methyltransferase activity
H9L18_RS03105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9L18_RS03110	COG2868	ribosomal protein
H9L18_RS03115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9L18_RS03120	COG0006	proline dipeptidase activity
H9L18_RS03125	COG1302	Protein conserved in bacteria
H9L18_RS03130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L18_RS03135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9L18_RS03140	COG1570	exodeoxyribonuclease VII activity
H9L18_RS03145	COG1722	exodeoxyribonuclease VII activity
H9L18_RS03155	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H9L18_RS03160	COG1438	arginine binding
H9L18_RS03165	COG0497	DNA recombination
H9L18_RS03180	COG2001	Belongs to the MraZ family
H9L18_RS03195	COG0768	penicillin binding
H9L18_RS03200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L18_RS03205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9L18_RS03210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9L18_RS03220	COG0849	cell division
H9L18_RS03230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9L18_RS03235	COG1799	cell septum assembly
H9L18_RS03250	COG3599	regulation of cell shape
H9L18_RS03255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9L18_RS03265	COG1174	glycine betaine transport
H9L18_RS03280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9L18_RS03290	COG0436	Aminotransferase
H9L18_RS03355	COG2268	Band 7 protein
H9L18_RS03365	COG4129	membrane
H9L18_RS03375	COG1876	peptidase activity
H9L18_RS03380	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9L18_RS03390	COG0681	Belongs to the peptidase S26 family
H9L18_RS03395	COG0351	phosphomethylpyrimidine kinase
H9L18_RS03415	COG2183	response to ionizing radiation
H9L18_RS03420	COG3091	SprT-like family
H9L18_RS03470	COG1801	Protein of unknown function DUF72
H9L18_RS03475	COG0561	phosphatase activity
H9L18_RS03485	COG1122	ATPase activity
H9L18_RS03490	COG1122	ATPase activity
H9L18_RS03495	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H9L18_RS03510	COG0527	aspartate kinase activity
H9L18_RS03515	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H9L18_RS03520	COG1104	cysteine desulfurase activity
H9L18_RS03525	COG0301	tRNA thio-modification
H9L18_RS03530	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H9L18_RS03535	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H9L18_RS03540	COG0525	valine-tRNA ligase activity
H9L18_RS03545	COG0285	dihydrofolate synthase activity
H9L18_RS03550	COG0546	phosphoglycolate phosphatase activity
H9L18_RS03555	COG2003	Belongs to the UPF0758 family
H9L18_RS03560	COG1278	Cold shock
H9L18_RS03575	COG5503	Protein of unknown function (DUF1447)
H9L18_RS03625	COG0673	inositol 2-dehydrogenase activity
H9L18_RS03630	COG0513	Belongs to the DEAD box helicase family
H9L18_RS03635	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H9L18_RS03635	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9L18_RS03645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L18_RS03670	COG1447	Phosphotransferase system cellobiose-specific component IIA
H9L18_RS03675	COG1902	pentaerythritol trinitrate reductase activity
H9L18_RS03680	COG1733	regulation of RNA biosynthetic process
H9L18_RS03695	COG1316	TRANSCRIPTIONal
H9L18_RS03705	COG0745	RESPONSE REGULATOR receiver
H9L18_RS03710	COG3850	Histidine kinase
H9L18_RS03710	COG5002	protein histidine kinase activity
H9L18_RS03745	COG2309	aminopeptidase activity
H9L18_RS03755	COG0716	FMN binding
H9L18_RS03760	COG0024	Methionine aminopeptidase
H9L18_RS03775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9L18_RS03790	COG3976	FMN-binding domain protein
H9L18_RS03790	COG0431	NADPH-dependent FMN reductase
H9L18_RS03790	COG1053	succinate dehydrogenase
H9L18_RS03800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L18_RS03805	COG1316	TRANSCRIPTIONal
H9L18_RS03810	COG1134	teichoic acid transport
H9L18_RS03815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9L18_RS03825	COG1682	transport, permease protein
H9L18_RS03830	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9L18_RS03835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9L18_RS03835	COG0463	Glycosyl transferase, family 2
H9L18_RS03840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H9L18_RS03850	COG0489	protein tyrosine kinase activity
H9L18_RS03855	COG4464	protein tyrosine phosphatase activity
H9L18_RS03865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9L18_RS03875	COG0438	transferase activity, transferring glycosyl groups
H9L18_RS03880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9L18_RS03880	COG0463	Glycosyl transferase, family 2
H9L18_RS03895	COG0438	transferase activity, transferring glycosyl groups
H9L18_RS03905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H9L18_RS03910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H9L18_RS03955	COG2137	regulation of response to DNA damage stimulus
H9L18_RS03960	COG1194	a g-specific adenine glycosylase
H9L18_RS03965	COG3557	Belongs to the UPF0374 family
H9L18_RS03980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9L18_RS03980	COG2755	lipolytic protein G-D-S-L family
H9L18_RS03990	COG0628	permease
H9L18_RS03995	COG1253	flavin adenine dinucleotide binding
H9L18_RS04005	COG0463	Glycosyl transferase, family 2
H9L18_RS04020	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9L18_RS04025	COG0463	Glycosyl transferase, family 2
H9L18_RS04030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9L18_RS04040	COG0542	response to heat
H9L18_RS04055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9L18_RS04060	COG0438	transferase activity, transferring glycosyl groups
H9L18_RS04065	COG0438	transferase activity, transferring glycosyl groups
H9L18_RS04075	COG2084	Dehydrogenase
H9L18_RS04080	COG4703	Protein of unknown function (DUF1797)
H9L18_RS04090	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9L18_RS04095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9L18_RS04100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9L18_RS04105	COG0745	RESPONSE REGULATOR receiver
H9L18_RS04110	COG5002	protein histidine kinase activity
H9L18_RS04120	COG2217	Heavy metal translocating P-type atpase
H9L18_RS04135	COG1204	response to ionizing radiation
H9L18_RS04145	COG2514	catechol 2,3-dioxygenase activity
H9L18_RS04150	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L18_RS04155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L18_RS04155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L18_RS04155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L18_RS04160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L18_RS04160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L18_RS04160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L18_RS04165	COG0383	alpha-mannosidase activity
H9L18_RS04175	COG2723	6-phospho-beta-galactosidase activity
H9L18_RS04180	COG1940	carbohydrate kinase activity
H9L18_RS04190	COG3620	sequence-specific DNA binding
H9L18_RS04220	COG1476	TRANSCRIPTIONal
H9L18_RS04225	COG2017	converts alpha-aldose to the beta-anomer
H9L18_RS04230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L18_RS04240	COG2190	(PTS) system
H9L18_RS04240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L18_RS04240	COG1263	PTS System
H9L18_RS04255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L18_RS04265	COG0584	glycerophosphoryl diester phosphodiesterase
H9L18_RS04270	COG2217	Heavy metal translocating P-type atpase
H9L18_RS04280	COG1929	Belongs to the glycerate kinase type-1 family
H9L18_RS04295	COG4175	Glycine betaine
H9L18_RS04295	COG3448	diguanylate cyclase activity
H9L18_RS04305	COG3942	CHAP domain
H9L18_RS04305	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9L18_RS04310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9L18_RS04320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9L18_RS04325	COG1522	sequence-specific DNA binding
H9L18_RS04335	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H9L18_RS04350	COG1126	abc transporter atp-binding protein
H9L18_RS04355	COG0765	amino acid transport
H9L18_RS04360	COG4166	transmembrane transport
H9L18_RS04365	COG4166	transmembrane transport
H9L18_RS04370	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9L18_RS04375	COG3711	transcriptional antiterminator
H9L18_RS04380	COG1263	PTS System
H9L18_RS04380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L18_RS04380	COG2190	(PTS) system
H9L18_RS04385	COG2723	6-phospho-beta-galactosidase activity
H9L18_RS04390	COG1609	Transcriptional regulator
H9L18_RS04410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L18_RS04430	COG1053	succinate dehydrogenase
H9L18_RS04440	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9L18_RS04440	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H9L18_RS04445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L18_RS04445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L18_RS04455	COG3715	PTS system
H9L18_RS04460	COG3716	PTS system mannose fructose sorbose family IID component
H9L18_RS04470	COG4166	transmembrane transport
H9L18_RS04480	COG0601	transmembrane transport
H9L18_RS04485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L18_RS04490	COG0444	Belongs to the ABC transporter superfamily
H9L18_RS04495	COG4608	Belongs to the ABC transporter superfamily
H9L18_RS04500	COG1446	asparaginase
H9L18_RS04505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L18_RS04515	COG0390	transport system, permease component
H9L18_RS04520	COG4619	ABC transporter
H9L18_RS04530	COG0572	uridine kinase
H9L18_RS04535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L18_RS04540	COG1098	S1 RNA binding domain
H9L18_RS04590	COG2246	polysaccharide biosynthetic process
H9L18_RS04600	COG1199	ATP-dependent helicase activity
H9L18_RS04600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9L18_RS04610	COG0436	Aminotransferase
H9L18_RS04620	COG2608	mercury ion transmembrane transporter activity
H9L18_RS04625	COG1309	transcriptional regulator
H9L18_RS04635	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H9L18_RS04645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H9L18_RS04650	COG1316	TRANSCRIPTIONal
H9L18_RS04660	COG0556	nucleotide-excision repair
H9L18_RS04665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L18_RS04675	COG1131	(ABC) transporter
H9L18_RS04685	COG1660	Displays ATPase and GTPase activities
H9L18_RS04695	COG1481	regulation of sporulation
H9L18_RS04700	COG3284	Transcriptional regulator
H9L18_RS04705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L18_RS04710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H9L18_RS04715	COG0022	dehydrogenase e1 component
H9L18_RS04720	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L18_RS04730	COG0740	serine-type endopeptidase activity
H9L18_RS04750	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H9L18_RS04755	COG2390	Transcriptional regulator
H9L18_RS04770	COG0149	triose-phosphate isomerase activity
H9L18_RS04775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H9L18_RS04825	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L18_RS04845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9L18_RS04850	COG0306	phosphate transporter
H9L18_RS04870	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L18_RS04895	COG1609	Transcriptional regulator
H9L18_RS04900	COG0024	Methionine aminopeptidase
H9L18_RS04905	COG0702	epimerase
H9L18_RS04910	COG0596	Alpha beta hydrolase
H9L18_RS04915	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H9L18_RS04925	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L18_RS04945	COG3314	Sporulation integral membrane protein YlbJ
H9L18_RS04955	COG1414	Transcriptional regulator
H9L18_RS04960	COG0346	lactoylglutathione lyase activity
H9L18_RS05030	COG4869	propanediol catabolic process
H9L18_RS05040	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
H9L18_RS05060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9L18_RS05065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9L18_RS05080	COG1120	ATPase activity
H9L18_RS05085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L18_RS05105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9L18_RS05110	COG0697	spore germination
H9L18_RS05115	COG3328	transposase activity
H9L18_RS05120	COG0493	'glutamate synthase
H9L18_RS05125	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H9L18_RS05125	COG0167	dihydroorotate dehydrogenase activity
H9L18_RS05130	COG1942	4-Oxalocrotonate Tautomerase
H9L18_RS05145	COG0557	exoribonuclease II activity
H9L18_RS05150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9L18_RS05155	COG0356	it plays a direct role in the translocation of protons across the membrane
H9L18_RS05160	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L18_RS05165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9L18_RS05170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L18_RS05175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9L18_RS05180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9L18_RS05185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9L18_RS05190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9L18_RS05195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L18_RS05205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9L18_RS05215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H9L18_RS05225	COG0559	Belongs to the binding-protein-dependent transport system permease family
H9L18_RS05235	COG0411	ABC transporter
H9L18_RS05300	COG3623	hexulose-6-phosphate isomerase
H9L18_RS05320	COG2188	Transcriptional regulator
H9L18_RS05325	COG1739	Uncharacterized protein family UPF0029
H9L18_RS05335	COG2267	carboxylic ester hydrolase activity
H9L18_RS05340	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H9L18_RS05345	COG1040	competence protein
H9L18_RS05410	COG4869	propanediol catabolic process
H9L18_RS05420	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
H9L18_RS05425	COG2096	Adenosyltransferase
H9L18_RS05440	COG1012	belongs to the aldehyde dehydrogenase family
H9L18_RS05440	COG1454	alcohol dehydrogenase
H9L18_RS05445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9L18_RS05450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9L18_RS05455	COG0653	protein targeting
H9L18_RS05465	COG2884	Cell division ATP-binding protein ftsE
H9L18_RS05470	COG2177	Part of the ABC transporter FtsEX involved in
H9L18_RS05480	COG0573	inorganic phosphate transmembrane transporter activity
H9L18_RS05485	COG0581	inorganic phosphate transmembrane transporter activity
H9L18_RS05490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9L18_RS05495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9L18_RS05505	COG0741	lytic transglycosylase activity
H9L18_RS05505	COG1196	nuclear chromosome segregation
H9L18_RS05505	COG0739	heme binding
H9L18_RS05520	COG1950	PFAM Membrane protein of
H9L18_RS05525	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H9L18_RS05530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9L18_RS05535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9L18_RS05540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H9L18_RS05550	COG1073	alpha beta
H9L18_RS05555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9L18_RS05560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9L18_RS05565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9L18_RS05570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9L18_RS05575	COG3870	Protein conserved in bacteria
H9L18_RS05580	COG0470	DNA polymerase III
H9L18_RS05585	COG1774	PSP1 C-terminal conserved region
H9L18_RS05590	COG4467	Involved in initiation control of chromosome replication
H9L18_RS05605	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9L18_RS05605	COG1388	LysM domain
H9L18_RS05610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L18_RS05625	COG4989	oxidoreductase activity
H9L18_RS05630	COG1131	(ABC) transporter
H9L18_RS05640	COG0516	GMP reductase activity
H9L18_RS05645	COG0561	phosphatase activity
H9L18_RS05650	COG1078	dGTPase activity
H9L18_RS05655	COG0095	Lipoate-protein ligase
H9L18_RS05665	COG3343	RNA polymerase activity
H9L18_RS05675	COG1012	belongs to the aldehyde dehydrogenase family
H9L18_RS05680	COG0191	fructose-bisphosphate aldolase activity
H9L18_RS05685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9L18_RS05690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H9L18_RS05695	COG0254	rRNA binding
H9L18_RS05710	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9L18_RS05715	COG1368	sulfuric ester hydrolase activity
H9L18_RS05720	COG0037	tRNA processing
H9L18_RS05750	COG3844	kynureninase activity
H9L18_RS05765	COG0488	(ABC) transporter
H9L18_RS05775	COG0574	Belongs to the PEP-utilizing enzyme family
H9L18_RS05775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9L18_RS05780	COG0517	IMP dehydrogenase activity
H9L18_RS05785	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9L18_RS05790	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
H9L18_RS05795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9L18_RS05815	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H9L18_RS05820	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L18_RS05825	COG1937	Protein conserved in bacteria
H9L18_RS05830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9L18_RS05835	COG1464	Belongs to the NlpA lipoprotein family
H9L18_RS05840	COG1464	Belongs to the NlpA lipoprotein family
H9L18_RS05845	COG0583	DNA-binding transcription factor activity
H9L18_RS05865	COG3104	oligopeptide transport
H9L18_RS05890	COG0719	Fe-S assembly protein
H9L18_RS05895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9L18_RS05900	COG0822	iron-sulfur transferase activity
H9L18_RS05905	COG0719	Fe-S assembly protein
H9L18_RS05925	COG0583	DNA-binding transcription factor activity
H9L18_RS05935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9L18_RS05950	COG4978	Transcriptional regulator
H9L18_RS05950	COG0789	Transcriptional regulator
H9L18_RS05955	COG4886	Leucine-rich repeat (LRR) protein
H9L18_RS05955	COG4932	domain protein
H9L18_RS06005	COG2223	nitrite transmembrane transporter activity
H9L18_RS06010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L18_RS06030	COG0351	phosphomethylpyrimidine kinase
H9L18_RS06035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9L18_RS06055	COG4895	conserved protein (DUF2196)
H9L18_RS06060	COG1671	Belongs to the UPF0178 family
H9L18_RS06065	COG4807	Protein conserved in bacteria
H9L18_RS06070	COG0318	PFAM AMP-dependent synthetase and ligase
H9L18_RS06075	COG0514	ATP-dependent DNA helicase (RecQ)
H9L18_RS06080	COG2390	Transcriptional regulator
H9L18_RS06085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H9L18_RS06090	COG0280	phosphate acetyltransferase
H9L18_RS06095	COG3426	butyrate kinase activity
H9L18_RS06100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L18_RS06105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H9L18_RS06110	COG0022	dehydrogenase e1 component
H9L18_RS06115	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L18_RS06125	COG0583	DNA-binding transcription factor activity
H9L18_RS06130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9L18_RS06140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9L18_RS06150	COG1979	alcohol dehydrogenase
H9L18_RS06160	COG2851	Citrate transporter
H9L18_RS06170	COG0511	ligase activity, forming carbon-carbon bonds
H9L18_RS06175	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H9L18_RS06190	COG3052	prosthetic group binding
H9L18_RS06200	COG3051	citrate lyase alpha subunit
H9L18_RS06205	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H9L18_RS06205	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
H9L18_RS06225	COG0745	RESPONSE REGULATOR receiver
H9L18_RS06230	COG4191	Histidine kinase
H9L18_RS06230	COG0784	Response regulator, receiver
H9L18_RS06235	COG2378	regulation of single-species biofilm formation
H9L18_RS06265	COG2610	gluconate transmembrane transporter activity
H9L18_RS06270	COG1028	Short-chain dehydrogenase reductase Sdr
H9L18_RS06280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H9L18_RS06285	COG0183	Belongs to the thiolase family
H9L18_RS06290	COG0583	DNA-binding transcription factor activity
H9L18_RS06295	COG2030	dehydratase
H9L18_RS06300	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9L18_RS06310	COG0583	DNA-binding transcription factor activity
H9L18_RS06315	COG1072	(Pantothenic acid kinase))
H9L18_RS06320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9L18_RS06325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L18_RS06330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L18_RS06335	COG2819	hydrolase of the alpha beta superfamily
H9L18_RS06340	COG1120	ATPase activity
H9L18_RS06350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9L18_RS06355	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9L18_RS06360	COG0302	gtp cyclohydrolase
H9L18_RS06365	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9L18_RS06370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9L18_RS06375	COG0531	amino acid
H9L18_RS06380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L18_RS06385	COG0833	amino acid
H9L18_RS06390	COG4187	Peptidase family M20/M25/M40
H9L18_RS06395	COG3457	Alanine racemase
H9L18_RS06400	COG3804	dihydrodipicolinate reductase
H9L18_RS06410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9L18_RS06420	COG5012	cobalamin binding
H9L18_RS06430	COG0583	DNA-binding transcription factor activity
H9L18_RS06460	COG2096	Adenosyltransferase
H9L18_RS06505	COG0531	amino acid
H9L18_RS06510	COG2309	aminopeptidase activity
H9L18_RS06515	COG1953	Uracil, thiamine, allantoin
H9L18_RS06520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L18_RS06525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L18_RS06530	COG2814	Major facilitator Superfamily
H9L18_RS06535	COG3257	ureidoglycine aminohydrolase activity
H9L18_RS06540	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H9L18_RS06545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9L18_RS06550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9L18_RS06565	COG2508	Transcriptional regulator
H9L18_RS06570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H9L18_RS06575	COG0737	Belongs to the 5'-nucleotidase family
H9L18_RS06600	COG1129	ABC transporter
H9L18_RS06615	COG0656	L-ascorbic acid biosynthetic process
H9L18_RS06620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L18_RS06625	COG1104	cysteine desulfurase activity
H9L18_RS06635	COG0247	lactate metabolic process
H9L18_RS06640	COG1139	Iron-sulfur cluster binding protein
H9L18_RS06650	COG2814	Major facilitator Superfamily
H9L18_RS06655	COG0482	sulfurtransferase activity
H9L18_RS06675	COG0551	DNA topoisomerase type I activity
H9L18_RS06675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9L18_RS06680	COG1012	belongs to the aldehyde dehydrogenase family
H9L18_RS06685	COG1674	ftsk spoiiie
H9L18_RS06685	COG1280	lysine exporter protein (LysE YggA)
H9L18_RS06695	COG1136	(ABC) transporter
H9L18_RS06700	COG0577	efflux transmembrane transporter activity
H9L18_RS06710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9L18_RS06715	COG1131	(ABC) transporter
H9L18_RS06725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9L18_RS06730	COG0768	penicillin binding
H9L18_RS06735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L18_RS06750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9L18_RS06755	COG0457	Tetratricopeptide repeat
H9L18_RS06755	COG0705	Rhomboid family
H9L18_RS06765	COG1940	carbohydrate kinase activity
H9L18_RS06770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9L18_RS06780	COG0584	glycerophosphoryl diester phosphodiesterase
H9L18_RS06785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9L18_RS06790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9L18_RS06795	COG0789	Transcriptional regulator
H9L18_RS06805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9L18_RS06820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L18_RS06825	COG0742	ribosomal rna small subunit methyltransferase
H9L18_RS06830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9L18_RS06835	COG3480	Lon protease (S16) C-terminal proteolytic domain
H9L18_RS06840	COG1555	photosystem II stabilization
H9L18_RS06845	COG2131	deaminase
H9L18_RS06850	COG2333	competence protein COMEC
H9L18_RS06850	COG0658	competence protein
H9L18_RS06855	COG1466	dna polymerase III delta subunit
H9L18_RS06865	COG1307	EDD domain protein, DegV family
H9L18_RS06875	COG2217	Heavy metal translocating P-type atpase
H9L18_RS06880	COG1968	undecaprenyl-diphosphatase activity
H9L18_RS06885	COG1263	PTS System
H9L18_RS06885	COG2190	(PTS) system
H9L18_RS06885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L18_RS06890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L18_RS06915	COG0052	Belongs to the universal ribosomal protein uS2 family
H9L18_RS06920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9L18_RS06925	COG0528	UMP kinase activity
H9L18_RS06930	COG0233	cytoplasmic translational termination
H9L18_RS06935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9L18_RS06940	COG4589	Belongs to the CDS family
H9L18_RS06945	COG0750	zinc metalloprotease
H9L18_RS06950	COG0442	prolyl-tRNA aminoacylation
H9L18_RS06960	COG1408	metallophosphoesterase
H9L18_RS06965	COG0779	Required for maturation of 30S ribosomal subunits
H9L18_RS06970	COG0195	Participates in both transcription termination and antitermination
H9L18_RS06975	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H9L18_RS06990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9L18_RS07005	COG0765	amino acid transport
H9L18_RS07010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L18_RS07015	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9L18_RS07020	COG0196	riboflavin kinase activity
H9L18_RS07025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9L18_RS07030	COG1288	antiporter activity
H9L18_RS07035	COG1420	regulation of RNA biosynthetic process
H9L18_RS07040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9L18_RS07045	COG0443	Heat shock 70 kDa protein
H9L18_RS07050	COG0484	heat shock protein binding
H9L18_RS07055	COG3443	Belongs to the bacterial solute-binding protein 9 family
H9L18_RS07055	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9L18_RS07065	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H9L18_RS07070	COG1132	(ABC) transporter
H9L18_RS07075	COG1132	(ABC) transporter
H9L18_RS07080	COG0745	RESPONSE REGULATOR receiver
H9L18_RS07085	COG5002	protein histidine kinase activity
H9L18_RS07090	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H9L18_RS07095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9L18_RS07120	COG1126	abc transporter atp-binding protein
H9L18_RS07125	COG0456	acetyltransferase
H9L18_RS07130	COG0228	four-way junction DNA binding
H9L18_RS07135	COG1837	Belongs to the UPF0109 family
H9L18_RS07145	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9L18_RS07150	COG0336	Belongs to the RNA methyltransferase TrmD family
H9L18_RS07155	COG0335	large ribosomal subunit rRNA binding
H9L18_RS07160	COG3321	synthase
H9L18_RS07160	COG0604	alcohol dehydrogenase
H9L18_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
H9L18_RS07165	COG1609	Transcriptional regulator
H9L18_RS07175	COG0772	Belongs to the SEDS family
H9L18_RS07180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9L18_RS07210	COG1027	Aspartate ammonia-lyase
H9L18_RS07215	COG0281	malic enzyme
H9L18_RS07220	COG0114	fumarate hydratase activity
H9L18_RS07250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9L18_RS07255	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H9L18_RS07260	COG4166	transmembrane transport
H9L18_RS07265	COG0477	Major facilitator Superfamily
H9L18_RS07270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9L18_RS07275	COG0509	glycine decarboxylation via glycine cleavage system
H9L18_RS07280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L18_RS07285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L18_RS07325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9L18_RS07330	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H9L18_RS07335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9L18_RS07340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9L18_RS07345	COG0287	Prephenate dehydrogenase
H9L18_RS07355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9L18_RS07360	COG0077	Prephenate dehydratase
H9L18_RS07375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L18_RS07385	COG0513	Belongs to the DEAD box helicase family
H9L18_RS07390	COG2153	protein acetylation
H9L18_RS07395	COG2267	carboxylic ester hydrolase activity
H9L18_RS07400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9L18_RS07425	COG1131	(ABC) transporter
H9L18_RS07430	COG1725	Transcriptional regulator
H9L18_RS07445	COG2814	Major facilitator Superfamily
H9L18_RS07460	COG0587	DNA-directed DNA polymerase activity
H9L18_RS07465	COG0205	6-phosphofructokinase activity
H9L18_RS07475	COG2814	Major facilitator Superfamily
H9L18_RS07495	COG2996	Protein conserved in bacteria
H9L18_RS07500	COG0735	belongs to the Fur family
H9L18_RS07505	COG0519	Catalyzes the synthesis of GMP from XMP
H9L18_RS07520	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H9L18_RS07525	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H9L18_RS07530	COG1187	pseudouridine synthase activity
H9L18_RS07535	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H9L18_RS07555	COG0514	ATP-dependent DNA helicase (RecQ)
H9L18_RS07560	COG1388	LysM domain
H9L18_RS07560	COG1134	teichoic acid transport
H9L18_RS07565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9L18_RS07570	COG0539	negative regulation of cytoplasmic translation
H9L18_RS07575	COG1160	GTP binding
H9L18_RS07585	COG1360	Flagellar Motor Protein
H9L18_RS07590	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H9L18_RS07595	COG1815	bacterial-type flagellum-dependent cell motility
H9L18_RS07605	COG1677	Flagellar hook-basal body complex protein FliE
H9L18_RS07610	COG1766	The M ring may be actively involved in energy transduction
H9L18_RS07615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H9L18_RS07625	COG1157	protein secretion by the type III secretion system
H9L18_RS07630	COG2882	bacterial-type flagellum organization
H9L18_RS07645	COG4786	Flagellar basal body rod
H9L18_RS07665	COG1338	Plays a role in the flagellum-specific transport system
H9L18_RS07675	COG1684	flagellar biosynthetic protein fliR
H9L18_RS07680	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H9L18_RS07685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H9L18_RS07690	COG1191	sigma factor activity
H9L18_RS07695	COG4786	Flagellar basal body rod
H9L18_RS07705	COG2884	Cell division ATP-binding protein ftsE
H9L18_RS07710	COG0840	transmembrane signaling receptor activity
H9L18_RS07715	COG0840	transmembrane signaling receptor activity
H9L18_RS07730	COG2201	protein-glutamate methylesterase activity
H9L18_RS07735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H9L18_RS07740	COG0643	Histidine kinase
H9L18_RS07740	COG2198	Histidine kinase
H9L18_RS07750	COG2201	protein-glutamate methylesterase activity
H9L18_RS07755	COG0835	chemotaxis
H9L18_RS07760	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H9L18_RS07765	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H9L18_RS07765	COG1776	CheC inhibitor of MCP methylation
H9L18_RS07780	COG4786	Flagellar basal body rod
H9L18_RS07780	COG1256	bacterial-type flagellum assembly
H9L18_RS07805	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H9L18_RS07815	COG1516	flagellar protein fliS
H9L18_RS07825	COG2261	transglycosylase associated protein
H9L18_RS07840	COG5582	Belongs to the UPF0302 family
H9L18_RS07845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L18_RS07850	COG1694	Mazg nucleotide pyrophosphohydrolase
H9L18_RS07855	COG0617	tRNA 3'-terminal CCA addition
H9L18_RS07870	COG0488	(ABC) transporter
H9L18_RS07875	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H9L18_RS07890	COG1272	protein, Hemolysin III
H9L18_RS07895	COG1307	EDD domain protein, DegV family
H9L18_RS07900	COG2755	lipolytic protein G-D-S-L family
H9L18_RS07915	COG4479	Belongs to the UPF0346 family
H9L18_RS07920	COG0793	Belongs to the peptidase S41A family
H9L18_RS07920	COG3409	Peptidoglycan-binding domain 1 protein
H9L18_RS07925	COG0681	Belongs to the peptidase S26 family
H9L18_RS07970	COG0582	viral genome integration into host DNA
H9L18_RS07980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L18_RS07985	COG0758	DNA mediated transformation
H9L18_RS07990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9L18_RS07995	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H9L18_RS08000	COG4974	Belongs to the 'phage' integrase family
H9L18_RS08005	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H9L18_RS08010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9L18_RS08025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9L18_RS08030	COG0735	belongs to the Fur family
H9L18_RS08040	COG1610	YqeY-like protein
H9L18_RS08045	COG1702	phosphate starvation-inducible protein PhoH
H9L18_RS08055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9L18_RS08060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9L18_RS08065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9L18_RS08070	COG1381	Involved in DNA repair and RecF pathway recombination
H9L18_RS08075	COG0752	glycyl-tRNA synthetase alpha subunit
H9L18_RS08080	COG0751	glycine-tRNA ligase activity
H9L18_RS08085	COG0577	efflux transmembrane transporter activity
H9L18_RS08090	COG1136	(ABC) transporter
H9L18_RS08100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L18_RS08105	COG0358	DNA primase activity
H9L18_RS08110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L18_RS08115	COG2384	SAM-dependent methyltransferase
H9L18_RS08120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H9L18_RS08125	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9L18_RS08130	COG0542	response to heat
H9L18_RS08135	COG3942	CHAP domain
H9L18_RS08135	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9L18_RS08165	COG1122	ATPase activity
H9L18_RS08175	COG0714	Associated with various cellular activities
H9L18_RS08195	COG0481	GTPase activity
H9L18_RS08245	COG4221	oxidoreductase activity
H9L18_RS08250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L18_RS08285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9L18_RS08290	COG0768	penicillin binding
H9L18_RS08305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L18_RS08310	COG3850	Histidine kinase
H9L18_RS08310	COG5002	protein histidine kinase activity
H9L18_RS08320	COG1136	(ABC) transporter
H9L18_RS08320	COG1136	(ABC) transporter
H9L18_RS08320	COG0577	efflux transmembrane transporter activity
H9L18_RS08320	COG0577	efflux transmembrane transporter activity
H9L18_RS08370	COG1131	(ABC) transporter
H9L18_RS08385	COG0519	Catalyzes the synthesis of GMP from XMP
H9L18_RS08445	COG4120	Belongs to the binding-protein-dependent transport system permease family
H9L18_RS08470	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H9L18_RS08480	COG0531	amino acid
H9L18_RS08490	COG1278	Cold shock
H9L18_RS08500	COG3223	Belongs to the PsiE family
H9L18_RS08510	COG0058	SHG alpha-glucan phosphorylase activity
H9L18_RS08515	COG0297	glycogen (starch) synthase activity
H9L18_RS08520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9L18_RS08525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9L18_RS08565	COG0167	dihydroorotate dehydrogenase activity
H9L18_RS08570	COG0543	2 iron, 2 sulfur cluster binding
H9L18_RS08575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9L18_RS08580	COG0505	Belongs to the CarA family
H9L18_RS08585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L18_RS08590	COG0540	Belongs to the ATCase OTCase family
H9L18_RS08595	COG2233	PERMEase
H9L18_RS08605	COG0564	pseudouridine synthase activity
H9L18_RS08615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L18_RS08625	COG1227	inorganic diphosphatase activity
H9L18_RS08630	COG2076	Multidrug Resistance protein
H9L18_RS08635	COG2076	Multidrug Resistance protein
H9L18_RS08640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9L18_RS08645	COG1882	Formate acetyltransferase
H9L18_RS08650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9L18_RS08655	COG0187	DNA topoisomerase II activity
H9L18_RS08665	COG0431	NADPH-dependent FMN reductase
H9L18_RS08670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L18_RS08690	COG0737	Belongs to the 5'-nucleotidase family
H9L18_RS08695	COG3639	organic phosphonate transmembrane transporter activity
H9L18_RS08730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9L18_RS08735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9L18_RS08745	COG1484	DNA-dependent DNA replication
H9L18_RS08755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9L18_RS08760	COG0237	dephospho-CoA kinase activity
H9L18_RS08765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9L18_RS08770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L18_RS08770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L18_RS08775	COG0670	Belongs to the BI1 family
H9L18_RS08785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L18_RS08820	COG0166	Belongs to the GPI family
H9L18_RS08825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H9L18_RS08830	COG2081	HI0933 family
H9L18_RS08835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9L18_RS08840	COG0710	3-dehydroquinate dehydratase activity
H9L18_RS08845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9L18_RS08850	COG1368	sulfuric ester hydrolase activity
H9L18_RS08865	COG2910	NAD(P)H-binding
H9L18_RS08870	COG1733	regulation of RNA biosynthetic process
H9L18_RS08875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L18_RS08880	COG1597	lipid kinase activity
H9L18_RS08885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L18_RS08890	COG0154	amidase activity
H9L18_RS08895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L18_RS08900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9L18_RS08905	COG0210	DNA helicase
H9L18_RS08910	COG1217	gtp-binding protein TYPA
H9L18_RS08915	COG0483	inositol monophosphate 1-phosphatase activity
H9L18_RS08920	COG4476	Belongs to the UPF0223 family
H9L18_RS08925	COG3850	Histidine kinase
H9L18_RS08925	COG5002	protein histidine kinase activity
H9L18_RS08930	COG0745	RESPONSE REGULATOR receiver
H9L18_RS08980	COG2207	Transcriptional regulator
H9L18_RS08980	COG3708	Transcriptional regulator
H9L18_RS09000	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H9L18_RS09005	COG0561	phosphatase activity
H9L18_RS09010	COG1132	(ABC) transporter
H9L18_RS09015	COG4988	ABC transporter
H9L18_RS09070	COG0640	Transcriptional regulator
H9L18_RS09090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L18_RS09090	COG1263	PTS System
H9L18_RS09095	COG2723	6-phospho-beta-galactosidase activity
H9L18_RS09100	COG2207	Transcriptional regulator
H9L18_RS09100	COG1917	Cupin 2, conserved barrel domain protein
H9L18_RS09105	COG2151	metal-sulfur cluster biosynthetic enzyme
H9L18_RS09110	COG0825	malonyl-CoA metabolic process
H9L18_RS09115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9L18_RS09120	COG0439	Biotin carboxylase
H9L18_RS09125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9L18_RS09135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L18_RS09145	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H9L18_RS09155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L18_RS09160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L18_RS09170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L18_RS09180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L18_RS09180	COG0072	phenylalanine-tRNA ligase activity
H9L18_RS09185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9L18_RS09190	COG1733	regulation of RNA biosynthetic process
H9L18_RS09200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L18_RS09205	COG1254	Belongs to the acylphosphatase family
H9L18_RS09215	COG0083	homoserine kinase activity
H9L18_RS09220	COG0460	homoserine dehydrogenase
H9L18_RS09225	COG0640	Transcriptional regulator
H9L18_RS09230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L18_RS09235	COG0492	ferredoxin-NADP+ reductase activity
H9L18_RS09240	COG0534	Mate efflux family protein
H9L18_RS09255	COG3833	ABC-type maltose transport systems, permease component
H9L18_RS09260	COG1175	transmembrane transport
H9L18_RS09265	COG2182	Extracellular solute-binding protein
H9L18_RS09275	COG0366	Alpha amylase catalytic
H9L18_RS09280	COG1609	Transcriptional regulator
H9L18_RS09290	COG1132	(ABC) transporter
H9L18_RS09295	COG1132	(ABC) transporter
H9L18_RS09300	COG3763	UPF0154 protein
H9L18_RS09305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H9L18_RS09315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L18_RS09320	COG1609	Transcriptional regulator
H9L18_RS09335	COG0668	transmembrane transport
H9L18_RS09350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H9L18_RS09365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9L18_RS09370	COG0456	acetyltransferase
H9L18_RS09380	COG1214	PFAM Peptidase M22, glycoprotease
H9L18_RS09385	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H9L18_RS09390	COG1253	flavin adenine dinucleotide binding
H9L18_RS09400	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H9L18_RS09405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9L18_RS09410	COG0363	glucosamine-6-phosphate deaminase activity
H9L18_RS09415	COG0488	(ABC) transporter
H9L18_RS09420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9L18_RS09425	COG4471	UPF0298 protein
H9L18_RS09440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H9L18_RS09445	COG0772	Belongs to the SEDS family
H9L18_RS09450	COG4838	Belongs to the UPF0358 family
H9L18_RS09455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H9L18_RS09465	COG4841	protein insertion into membrane
H9L18_RS09470	COG0569	domain protein
H9L18_RS09475	COG2197	response regulator
H9L18_RS09480	COG4585	Histidine kinase
H9L18_RS09490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L18_RS09495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9L18_RS09500	COG2824	Alkylphosphonate utilization operon protein PhnA
H9L18_RS09505	COG1410	methionine synthase
H9L18_RS09505	COG0646	methionine synthase
H9L18_RS09525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L18_RS09530	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H9L18_RS09530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9L18_RS09535	COG0726	polysaccharide deacetylase
H9L18_RS09545	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H9L18_RS09550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L18_RS09555	COG1696	Membrane protein involved in D-alanine export
H9L18_RS09560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H9L18_RS09680	COG0735	belongs to the Fur family
H9L18_RS09685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9L18_RS09690	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9L18_RS09700	COG1278	Cold shock
H9L18_RS09710	COG0328	RNA-DNA hybrid ribonuclease activity
H9L18_RS09725	COG1757	Na H antiporter
H9L18_RS09735	COG0531	amino acid
H9L18_RS09750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9L18_RS09760	COG4608	Belongs to the ABC transporter superfamily
H9L18_RS09765	COG0444	Belongs to the ABC transporter superfamily
H9L18_RS09770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L18_RS09775	COG0601	transmembrane transport
H9L18_RS09785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L18_RS09790	COG3442	glutamine amidotransferase
H9L18_RS09795	COG0686	Belongs to the AlaDH PNT family
H9L18_RS09800	COG1482	cell wall glycoprotein biosynthetic process
H9L18_RS09805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9L18_RS09815	COG1132	(ABC) transporter
H9L18_RS09830	COG0492	ferredoxin-NADP+ reductase activity
H9L18_RS09835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H9L18_RS09845	COG0647	UMP catabolic process
H9L18_RS09850	COG4470	Protein conserved in bacteria
H9L18_RS09855	COG0737	Belongs to the 5'-nucleotidase family
H9L18_RS09860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L18_RS09865	COG2365	Tyrosine phosphatase family
H9L18_RS09880	COG1131	(ABC) transporter
H9L18_RS09890	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9L18_RS09910	COG3964	amidohydrolase
H9L18_RS09925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L18_RS09940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9L18_RS09965	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H9L18_RS09970	COG0116	Belongs to the methyltransferase superfamily
H9L18_RS09985	COG3331	DNA recombination
H9L18_RS09990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L18_RS09995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9L18_RS10005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9L18_RS10010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9L18_RS10015	COG0009	L-threonylcarbamoyladenylate synthase
H9L18_RS10020	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L18_RS10025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9L18_RS10030	COG1435	thymidine kinase activity
H9L18_RS10035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9L18_RS10040	COG0628	permease
H9L18_RS10050	COG2706	6-phosphogluconolactonase activity
H9L18_RS10075	COG2855	membrane
H9L18_RS10080	COG1335	isochorismatase
H9L18_RS10085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9L18_RS10095	COG0494	nUDIX hydrolase
H9L18_RS10105	COG3853	Toxic anion resistance protein (TelA)
H9L18_RS10120	COG1074	ATP-dependent DNA helicase activity
H9L18_RS10125	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H9L18_RS10155	COG1396	sequence-specific DNA binding
H9L18_RS10160	COG2807	transmembrane transport
H9L18_RS10175	COG0383	alpha-mannosidase activity
H9L18_RS10195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9L18_RS10210	COG1363	Peptidase, m42
H9L18_RS10215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9L18_RS10220	COG3425	synthase
H9L18_RS10235	COG1136	(ABC) transporter
H9L18_RS10240	COG0577	efflux transmembrane transporter activity
H9L18_RS10250	COG0006	proline dipeptidase activity
H9L18_RS10255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L18_RS10265	COG0504	CTP synthase activity
H9L18_RS10285	COG0022	dehydrogenase e1 component
H9L18_RS10295	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L18_RS10300	COG0351	phosphomethylpyrimidine kinase
H9L18_RS10310	COG0183	Belongs to the thiolase family
H9L18_RS10315	COG0366	Alpha amylase catalytic
H9L18_RS10320	COG0395	ABC-type sugar transport system, permease component
H9L18_RS10330	COG1653	transport
H9L18_RS10355	COG1428	Deoxynucleoside kinase
H9L18_RS10370	COG0590	tRNA wobble adenosine to inosine editing
H9L18_RS10380	COG2738	Putative neutral zinc metallopeptidase
H9L18_RS10390	COG3706	GGDEF domain
H9L18_RS10400	COG0716	FMN binding
H9L18_RS10405	COG0509	glycine decarboxylation via glycine cleavage system
H9L18_RS10410	COG1393	Belongs to the ArsC family
H9L18_RS10420	COG0772	Belongs to the SEDS family
H9L18_RS10430	COG0300	oxidoreductase activity
H9L18_RS10435	COG1234	tRNA 3'-trailer cleavage
H9L18_RS10445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9L18_RS10450	COG1121	(ABC) transporter
H9L18_RS10460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9L18_RS10470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L18_RS10475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9L18_RS10505	COG1304	FMN binding
H9L18_RS10510	COG3655	Transcriptional regulator
H9L18_RS10530	COG1323	Belongs to the UPF0348 family
H9L18_RS10535	COG2226	methyltransferase
H9L18_RS10540	COG0799	negative regulation of ribosome biogenesis
H9L18_RS10545	COG1713	HD superfamily hydrolase involved in NAD metabolism
H9L18_RS10550	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9L18_RS10555	COG1534	Rna-binding protein
H9L18_RS10560	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H9L18_RS10570	COG2357	RelA SpoT domain protein
H9L18_RS10580	COG0151	Belongs to the GarS family
H9L18_RS10585	COG0138	bifunctional purine biosynthesis protein purh
H9L18_RS10590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9L18_RS10595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9L18_RS10605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L18_RS10615	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L18_RS10620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9L18_RS10635	COG1136	(ABC) transporter
H9L18_RS10645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9L18_RS10650	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9L18_RS10655	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9L18_RS10660	COG1070	Carbohydrate kinase
H9L18_RS10685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9L18_RS10690	COG1228	amidohydrolase
H9L18_RS10695	COG1597	lipid kinase activity
H9L18_RS10705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L18_RS10710	COG0124	histidyl-tRNA synthetase
H9L18_RS10720	COG0531	amino acid
H9L18_RS10730	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H9L18_RS10735	COG3404	Formiminotransferase-cyclodeaminase
H9L18_RS10750	COG0531	amino acid
H9L18_RS10755	COG2188	Transcriptional regulator
H9L18_RS10760	COG1554	hydrolase, family 65, central catalytic
H9L18_RS10765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L18_RS10765	COG1263	PTS System
H9L18_RS10790	COG3338	carbonate dehydratase activity
H9L18_RS10795	COG1268	BioY protein
H9L18_RS10800	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H9L18_RS10800	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H9L18_RS10805	COG0765	amino acid transport
H9L18_RS10810	COG0765	amino acid transport
H9L18_RS10815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L18_RS10830	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H9L18_RS10835	COG0488	(ABC) transporter
H9L18_RS10845	COG1794	racemase activity, acting on amino acids and derivatives
H9L18_RS10855	COG0367	asparagine synthase
H9L18_RS10860	COG5002	protein histidine kinase activity
H9L18_RS10895	COG1131	(ABC) transporter
H9L18_RS10900	COG0626	cystathionine gamma-synthase activity
H9L18_RS10910	COG4716	Myosin-crossreactive antigen
H9L18_RS10920	COG0456	acetyltransferase
H9L18_RS10925	COG1921	L-seryl-tRNASec selenium transferase activity
H9L18_RS10945	COG0425	Belongs to the sulfur carrier protein TusA family
H9L18_RS10950	COG0709	Synthesizes selenophosphate from selenide and ATP
H9L18_RS10965	COG0252	asparaginase activity
H9L18_RS10965	COG5275	peptidyl-tyrosine sulfation
H9L18_RS10985	COG0252	asparaginase activity
H9L18_RS10985	COG5275	peptidyl-tyrosine sulfation
H9L18_RS10995	COG1924	4 iron, 4 sulfur cluster binding
H9L18_RS11000	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
H9L18_RS11005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9L18_RS11015	COG4753	response regulator
H9L18_RS11015	COG2207	Transcriptional regulator
H9L18_RS11020	COG2972	Histidine kinase
H9L18_RS11030	COG1653	transport
H9L18_RS11035	COG0395	ABC-type sugar transport system, permease component
H9L18_RS11040	COG1175	transmembrane transport
H9L18_RS11045	COG2957	Belongs to the agmatine deiminase family
H9L18_RS11055	COG1704	LemA family
H9L18_RS11060	COG0546	phosphoglycolate phosphatase activity
H9L18_RS11100	COG3201	nicotinamide mononucleotide transporter
H9L18_RS11115	COG4975	Glucose uptake
H9L18_RS11120	COG1869	D-ribose catabolic process
H9L18_RS11145	COG2205	protein histidine kinase activity
H9L18_RS11150	COG0745	RESPONSE REGULATOR receiver
H9L18_RS11155	COG1609	Transcriptional regulator
H9L18_RS11160	COG1305	Transglutaminase-like
H9L18_RS11170	COG0714	Associated with various cellular activities
H9L18_RS11190	COG3590	peptidase
H9L18_RS11195	COG5002	protein histidine kinase activity
H9L18_RS11205	COG0513	Belongs to the DEAD box helicase family
H9L18_RS11220	COG1217	gtp-binding protein TYPA
H9L18_RS11230	COG1131	(ABC) transporter
H9L18_RS11290	COG0251	oxidation-reduction process
H9L18_RS11295	COG0235	Class ii aldolase
H9L18_RS11300	COG1454	alcohol dehydrogenase
H9L18_RS11305	COG1069	ribulokinase activity
H9L18_RS11320	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9L18_RS11325	COG1129	ABC transporter
H9L18_RS11335	COG1070	Carbohydrate kinase
H9L18_RS11340	COG0235	Class ii aldolase
H9L18_RS11345	COG1349	DNA-binding transcription factor activity
H9L18_RS11350	COG0351	phosphomethylpyrimidine kinase
H9L18_RS11355	COG0352	thiamine-phosphate diphosphorylase activity
H9L18_RS11370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9L18_RS11380	COG1122	ATPase activity
H9L18_RS11410	COG0564	pseudouridine synthase activity
H9L18_RS11425	COG0745	RESPONSE REGULATOR receiver
H9L18_RS11450	COG0789	Transcriptional regulator
H9L18_RS11450	COG4978	Transcriptional regulator
H9L18_RS11455	COG4978	Transcriptional regulator
H9L18_RS11455	COG0789	Transcriptional regulator
H9L18_RS11470	COG1132	(ABC) transporter
H9L18_RS11475	COG0406	alpha-ribazole phosphatase activity
H9L18_RS11480	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H9L18_RS11495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9L18_RS11510	COG0181	hydroxymethylbilane synthase activity
H9L18_RS11515	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9L18_RS11520	COG1648	precorrin-2 dehydrogenase activity
H9L18_RS11530	COG1492	cobalamin metabolic process
H9L18_RS11550	COG0310	cobalt ion transport
H9L18_RS11600	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
H9L18_RS11610	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H9L18_RS11640	COG4820	ethanolamine utilization protein (EutJ)
H9L18_RS11650	COG3192	ethanolamine utilization protein
H9L18_RS11655	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
H9L18_RS11665	COG4869	propanediol catabolic process
H9L18_RS11680	COG1454	alcohol dehydrogenase
H9L18_RS11680	COG1012	belongs to the aldehyde dehydrogenase family
H9L18_RS11695	COG4302	ethanolamine ammonia-lyase activity
H9L18_RS11700	COG4303	Ethanolamine ammonia lyase large subunit
H9L18_RS11730	COG2096	Adenosyltransferase
H9L18_RS11740	COG4810	utilization protein
H9L18_RS11750	COG4656	Part of a membrane complex involved in electron transport
H9L18_RS11760	COG1201	RNA secondary structure unwinding
H9L18_RS11790	COG3118	belongs to the thioredoxin family
H9L18_RS11825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H9L18_RS11840	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
H9L18_RS11845	COG2244	polysaccharide biosynthetic process
H9L18_RS11865	COG3328	transposase activity
H9L18_RS11870	COG3620	sequence-specific DNA binding
H9L18_RS11890	COG0217	transcriptional regulatory protein
H9L18_RS11895	COG1187	pseudouridine synthase activity
H9L18_RS11900	COG0456	acetyltransferase
H9L18_RS11910	COG0010	Belongs to the arginase family
H9L18_RS11920	COG2271	Major facilitator Superfamily
H9L18_RS11925	COG1473	amidohydrolase
H9L18_RS11950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H9L18_RS11985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L18_RS11990	COG0546	phosphoglycolate phosphatase activity
H9L18_RS12000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L18_RS12020	COG1132	(ABC) transporter
H9L18_RS12030	COG0159	tryptophan synthase activity
H9L18_RS12045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L18_RS12050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L18_RS12060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9L18_RS12075	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H9L18_RS12080	COG3457	Alanine racemase
H9L18_RS12090	COG2188	Transcriptional regulator
H9L18_RS12095	COG0626	cystathionine gamma-synthase activity
H9L18_RS12130	COG1573	uracil-dna glycosylase
H9L18_RS12145	COG0745	RESPONSE REGULATOR receiver
H9L18_RS12150	COG1408	metallophosphoesterase
H9L18_RS12170	COG0183	Belongs to the thiolase family
H9L18_RS12175	COG1024	Enoyl-CoA hydratase
H9L18_RS12175	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9L18_RS12180	COG0427	acetyl-CoA hydrolase
H9L18_RS12185	COG1024	Enoyl-CoA hydratase
H9L18_RS12190	COG1024	Enoyl-CoA hydratase
H9L18_RS12200	COG2723	6-phospho-beta-galactosidase activity
H9L18_RS12205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L18_RS12205	COG2190	(PTS) system
H9L18_RS12205	COG1263	PTS System
H9L18_RS12215	COG1396	sequence-specific DNA binding
H9L18_RS12220	COG3048	D-serine ammonia-lyase activity
H9L18_RS12225	COG2610	gluconate transmembrane transporter activity
H9L18_RS12230	COG0251	oxidation-reduction process
H9L18_RS12240	COG3328	transposase activity
H9L18_RS12245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L18_RS12245	COG3711	transcriptional antiterminator
H9L18_RS12250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L18_RS12260	COG2723	6-phospho-beta-galactosidase activity
H9L18_RS12270	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H9L18_RS12275	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H9L18_RS12285	COG1802	Transcriptional regulator
H9L18_RS12315	COG1132	(ABC) transporter
H9L18_RS12335	COG0456	acetyltransferase
H9L18_RS12335	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H9L18_RS12340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H9L18_RS12345	COG1309	transcriptional regulator
H9L18_RS12350	COG1193	negative regulation of DNA recombination
H9L18_RS12355	COG1132	(ABC) transporter
H9L18_RS12360	COG1132	(ABC) transporter
H9L18_RS12365	COG2207	Transcriptional regulator
H9L18_RS12385	COG4821	SIS domain
H9L18_RS12390	COG3037	sugar-specific permease SgaT UlaA
H9L18_RS12400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L18_RS12405	COG3711	transcriptional antiterminator
H9L18_RS12410	COG3588	fructose-bisphosphate aldolase
H9L18_RS12415	COG3328	transposase activity
H9L18_RS12425	COG0402	S-adenosylhomocysteine deaminase activity
H9L18_RS12455	COG3395	kinase activity
H9L18_RS12470	COG0698	ribose 5-phosphate isomerase
H9L18_RS12485	COG0577	efflux transmembrane transporter activity
H9L18_RS12490	COG1136	(ABC) transporter
H9L18_RS12495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L18_RS12560	COG3715	PTS system
H9L18_RS12565	COG3716	PTS system mannose fructose sorbose family IID component
H9L18_RS12570	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H9L18_RS12570	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9L18_RS12620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9L18_RS12625	COG1278	Cold shock
H9L18_RS12640	COG2207	Transcriptional regulator
H9L18_RS12655	COG3279	Response regulator of the LytR AlgR family
H9L18_RS12660	COG3290	protein histidine kinase activity
H9L18_RS12670	COG1131	(ABC) transporter
H9L18_RS12680	COG1131	(ABC) transporter
H9L18_RS12690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9L18_RS12705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9L18_RS12710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L18_RS12715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H9L18_RS12730	COG5002	protein histidine kinase activity
H9L18_RS12735	COG0745	RESPONSE REGULATOR receiver
H9L18_RS12770	COG0582	viral genome integration into host DNA
H9L18_RS12805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9L18_RS12810	COG1780	Probably involved in ribonucleotide reductase function
H9L18_RS12815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L18_RS12830	COG4862	establishment of competence for transformation
H9L18_RS12835	COG1393	Belongs to the ArsC family
H9L18_RS12840	COG0180	Tryptophanyl-tRNA synthetase
H9L18_RS12845	COG0740	serine-type endopeptidase activity
H9L18_RS12860	COG0095	Lipoate-protein ligase
H9L18_RS12865	COG1234	tRNA 3'-trailer cleavage
H9L18_RS12870	COG0577	efflux transmembrane transporter activity
H9L18_RS12875	COG1136	(ABC) transporter
H9L18_RS12890	COG1363	Peptidase, m42
H9L18_RS12900	COG0577	efflux transmembrane transporter activity
H9L18_RS12905	COG1136	(ABC) transporter
H9L18_RS12915	COG0745	RESPONSE REGULATOR receiver
H9L18_RS12920	COG0642	Histidine kinase
H9L18_RS12935	COG2340	Cysteine-rich secretory protein family
H9L18_RS12960	COG1464	Belongs to the NlpA lipoprotein family
H9L18_RS12965	COG2011	ABC-type metal ion transport system permease component
H9L18_RS12970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9L18_RS12975	COG0095	Lipoate-protein ligase
H9L18_RS12985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9L18_RS12990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9L18_RS12995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9L18_RS13020	COG0737	Belongs to the 5'-nucleotidase family
H9L18_RS13025	COG2376	Dihydroxyacetone kinase
H9L18_RS13035	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H9L18_RS13040	COG1461	Dihydroxyacetone kinase
H9L18_RS13045	COG2376	Dihydroxyacetone kinase
H9L18_RS13050	COG1309	transcriptional regulator
H9L18_RS13060	COG1959	2 iron, 2 sulfur cluster binding
H9L18_RS13070	COG1131	(ABC) transporter
H9L18_RS13075	COG1725	Transcriptional regulator
H9L18_RS13105	COG1185	polyribonucleotide nucleotidyltransferase activity
H9L18_RS13110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9L18_RS13115	COG0242	peptide deformylase activity
H9L18_RS13120	COG0561	phosphatase activity
H9L18_RS13135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9L18_RS13145	COG1668	transmembrane transport
H9L18_RS13150	COG4152	abc transporter atp-binding protein
H9L18_RS13175	COG0322	excinuclease ABC activity
H9L18_RS13180	COG3118	belongs to the thioredoxin family
H9L18_RS13185	COG1193	negative regulation of DNA recombination
H9L18_RS13200	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L18_RS13205	COG3906	Belongs to the UPF0473 family
H9L18_RS13210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9L18_RS13215	COG4472	Bacterial protein of unknown function (DUF965)
H9L18_RS13220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L18_RS13230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L18_RS13235	COG1363	Peptidase, m42
H9L18_RS13245	COG3620	sequence-specific DNA binding
H9L18_RS13265	COG1694	Mazg nucleotide pyrophosphohydrolase
H9L18_RS13270	COG1611	Belongs to the LOG family
H9L18_RS13275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9L18_RS13280	COG0510	thiamine kinase activity
H9L18_RS13285	COG4473	ABC transporter
H9L18_RS13290	COG1131	(ABC) transporter
H9L18_RS13295	COG0537	adenosine 5'-monophosphoramidase activity
H9L18_RS13300	COG4980	gas vesicle protein
H9L18_RS13305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9L18_RS13310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L18_RS13315	COG4466	Protein conserved in bacteria
H9L18_RS13325	COG3688	RNA-binding protein containing a PIN domain
H9L18_RS13330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L18_RS13335	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H9L18_RS13340	COG0215	cysteine-tRNA ligase activity
H9L18_RS13345	COG1045	serine acetyltransferase
H9L18_RS13350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L18_RS13355	COG4956	integral membrane protein (PIN domain superfamily)
H9L18_RS13365	COG0756	dUTP diphosphatase activity
H9L18_RS13370	COG3158	transport of potassium into the cell
H9L18_RS13390	COG0561	phosphatase activity
H9L18_RS13395	COG2723	6-phospho-beta-galactosidase activity
H9L18_RS13400	COG2190	(PTS) system
H9L18_RS13400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L18_RS13400	COG1263	PTS System
H9L18_RS13415	COG0783	Belongs to the Dps family
H9L18_RS13425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H9L18_RS13430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9L18_RS13435	COG0085	RNA polymerase activity
H9L18_RS13440	COG2813	Specifically methylates the guanine in position
H9L18_RS13445	COG2755	lipolytic protein G-D-S-L family
H9L18_RS13450	COG1607	acyl-coa hydrolase
H9L18_RS13455	COG1072	(Pantothenic acid kinase))
H9L18_RS13460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9L18_RS13460	COG0519	Catalyzes the synthesis of GMP from XMP
H9L18_RS13505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9L18_RS13550	COG2267	carboxylic ester hydrolase activity
H9L18_RS13555	COG2378	regulation of single-species biofilm formation
H9L18_RS13560	COG0280	phosphate acetyltransferase
H9L18_RS13565	COG3426	butyrate kinase activity
H9L18_RS13575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9L18_RS13605	COG0456	acetyltransferase
H9L18_RS13625	COG1309	transcriptional regulator
H9L18_RS13645	COG0384	phenazine biosynthesis protein PhzF
H9L18_RS13655	COG1846	Transcriptional regulator
H9L18_RS13660	COG0789	Transcriptional regulator
H9L18_RS13665	COG2252	PERMEase
H9L18_RS13670	COG3022	response to hydroperoxide
H9L18_RS13685	COG0435	Glutathione S-transferase
H9L18_RS13690	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L18_RS13700	COG0842	Transport permease protein
H9L18_RS13705	COG1131	(ABC) transporter
H9L18_RS13715	COG0697	spore germination
H9L18_RS13725	COG0076	glutamate decarboxylase activity
H9L18_RS13760	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
H9L18_RS13765	COG1714	RDD family
H9L18_RS13805	COG0251	oxidation-reduction process
H9L18_RS13810	COG1285	pathogenesis
H9L18_RS13820	COG2217	Heavy metal translocating P-type atpase
H9L18_RS13830	COG2132	Multicopper oxidase
H9L18_RS13835	COG0745	RESPONSE REGULATOR receiver
H9L18_RS13840	COG5002	protein histidine kinase activity
H9L18_RS13860	COG2755	lipolytic protein G-D-S-L family
H9L18_RS13860	COG0657	acetylesterase activity
H9L18_RS13865	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H9L18_RS13875	COG2814	Major facilitator Superfamily
H9L18_RS13885	COG1609	Transcriptional regulator
H9L18_RS13895	COG1120	ATPase activity
H9L18_RS13900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L18_RS13905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L18_RS13925	COG1725	Transcriptional regulator
H9L18_RS14020	COG2207	Transcriptional regulator
H9L18_RS14020	COG1917	Cupin 2, conserved barrel domain protein
H9L18_RS14050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L18_RS14050	COG3711	transcriptional antiterminator
H9L18_RS14060	COG0726	polysaccharide deacetylase
H9L18_RS14070	COG2814	Major facilitator Superfamily
H9L18_RS14075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L18_RS14115	COG1131	(ABC) transporter
H9L18_RS14135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9L18_RS14140	COG0726	polysaccharide deacetylase
H9L18_RS14140	COG1649	PFAM Uncharacterised BCR, COG1649
H9L18_RS14145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H9L18_RS14150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9L18_RS14155	COG1695	Transcriptional regulator
H9L18_RS14170	COG0025	NhaP-type Na H and K H
H9L18_RS14180	COG0561	phosphatase activity
H9L18_RS14185	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9L18_RS14190	COG0280	phosphate acetyltransferase
H9L18_RS14195	COG0802	atpase or kinase
H9L18_RS14205	COG2176	DNA-directed DNA polymerase activity
H9L18_RS14215	COG0708	Exodeoxyribonuclease III
H9L18_RS14220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9L18_RS14225	COG0038	chloride channel
H9L18_RS14230	COG0492	ferredoxin-NADP+ reductase activity
H9L18_RS14245	COG1473	amidohydrolase
H9L18_RS14250	COG0604	alcohol dehydrogenase
H9L18_RS14260	COG3842	ATPase activity
H9L18_RS14265	COG1176	ABC-type spermidine putrescine transport system, permease component I
H9L18_RS14270	COG1177	transmembrane transport
H9L18_RS14280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9L18_RS14295	COG1121	(ABC) transporter
H9L18_RS14300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9L18_RS14320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L18_RS14330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9L18_RS14335	COG1970	mechanosensitive ion channel activity
H9L18_RS14340	COG0612	Peptidase, M16
H9L18_RS14345	COG0612	Peptidase, M16
H9L18_RS14350	COG1426	Protein conserved in bacteria
H9L18_RS14355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9L18_RS14375	COG0628	permease
H9L18_RS14385	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9L18_RS14390	COG0488	(ABC) transporter
H9L18_RS14395	COG1609	Transcriptional regulator
H9L18_RS14410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9L18_RS14430	COG3655	Transcriptional regulator
H9L18_RS14455	COG1394	ATPase activity, coupled to movement of substances
H9L18_RS14460	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
H9L18_RS14465	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
H9L18_RS14470	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
H9L18_RS14475	COG1527	subunit (C
H9L18_RS14485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L18_RS14490	COG1269	ATP hydrolysis coupled proton transport
H9L18_RS14500	COG2169	Transcriptional regulator
H9L18_RS14500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L18_RS14505	COG0142	geranyltranstransferase activity
H9L18_RS14520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9L18_RS14540	COG3620	sequence-specific DNA binding
H9L18_RS14565	COG1131	(ABC) transporter
H9L18_RS14615	COG1054	Belongs to the UPF0176 family
H9L18_RS14635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L18_RS14665	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H9L18_RS14670	COG4988	ABC transporter
H9L18_RS14675	COG1294	oxidase, subunit
H9L18_RS14680	COG1271	oxidase subunit
H9L18_RS14685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L18_RS14690	COG0826	peptidase U32
H9L18_RS14695	COG0826	peptidase U32
H9L18_RS14705	COG4463	regulation of RNA biosynthetic process
H9L18_RS14740	COG0739	heme binding
H9L18_RS14795	COG3942	CHAP domain
H9L18_RS14795	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9L18_RS14855	COG1192	Involved in chromosome partitioning
H9L18_RS14860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H9L18_RS14875	COG0577	efflux transmembrane transporter activity
H9L18_RS14875	COG1136	(ABC) transporter
H9L18_RS14915	COG2076	Multidrug Resistance protein
H9L18_RS14920	COG2076	Multidrug Resistance protein
H9L18_RS14965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L18_RS15040	COG1278	Cold shock
H9L18_RS15050	COG0686	Belongs to the AlaDH PNT family
H9L18_RS15055	COG1764	response to oxidative stress
H9L18_RS15125	COG2217	Heavy metal translocating P-type atpase
H9L18_RS15130	COG0640	Transcriptional regulator
H9L18_RS15195	COG1192	Involved in chromosome partitioning
H9L18_RS15220	COG2003	Belongs to the UPF0758 family
H9L18_RS15235	COG3328	transposase activity
H9L18_RS15245	COG2261	transglycosylase associated protein
H9L18_RS15265	COG3328	transposase activity