locus-tag	class	description
K5K99_RS00060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5K99_RS00105	COG0582	viral genome integration into host DNA
K5K99_RS00110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K99_RS00125	COG0456	acetyltransferase
K5K99_RS00130	COG0431	NADPH-dependent FMN reductase
K5K99_RS00135	COG1597	lipid kinase activity
K5K99_RS00140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5K99_RS00145	COG0406	alpha-ribazole phosphatase activity
K5K99_RS00150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K5K99_RS00155	COG0500	methyltransferase
K5K99_RS00160	COG3142	Participates in the control of copper homeostasis
K5K99_RS00180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5K99_RS00185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5K99_RS00190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K99_RS00195	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5K99_RS00195	COG3443	Belongs to the bacterial solute-binding protein 9 family
K5K99_RS00200	COG0626	cystathionine gamma-synthase activity
K5K99_RS00205	COG0251	oxidation-reduction process
K5K99_RS00210	COG0842	Transport permease protein
K5K99_RS00215	COG1131	(ABC) transporter
K5K99_RS00235	COG2239	Acts as a magnesium transporter
K5K99_RS00240	COG0564	pseudouridine synthase activity
K5K99_RS00245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K5K99_RS00250	COG2357	RelA SpoT domain protein
K5K99_RS00255	COG4116	CYTH
K5K99_RS00260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K5K99_RS00265	COG1164	Oligoendopeptidase f
K5K99_RS00275	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5K99_RS00280	COG0488	(ABC) transporter
K5K99_RS00285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5K99_RS00300	COG0459	protein refolding
K5K99_RS00310	COG0783	Belongs to the Dps family
K5K99_RS00315	COG0693	protein deglycase activity
K5K99_RS00335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K5K99_RS00350	COG0183	Belongs to the thiolase family
K5K99_RS00355	COG1028	Short-chain dehydrogenase reductase Sdr
K5K99_RS00360	COG0583	DNA-binding transcription factor activity
K5K99_RS00370	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5K99_RS00375	COG4670	ketone body catabolic process
K5K99_RS00380	COG0583	DNA-binding transcription factor activity
K5K99_RS00395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K5K99_RS00400	COG4109	DRTGG domain
K5K99_RS00405	COG2814	Major facilitator Superfamily
K5K99_RS00415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5K99_RS00420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K5K99_RS00425	COG4720	Psort location CytoplasmicMembrane, score
K5K99_RS00430	COG1132	(ABC) transporter
K5K99_RS00435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5K99_RS00440	COG0419	ATPase involved in DNA repair
K5K99_RS00445	COG0420	3'-5' exonuclease activity
K5K99_RS00450	COG1309	transcriptional regulator
K5K99_RS00460	COG1131	(ABC) transporter
K5K99_RS00465	COG0204	Acyl-transferase
K5K99_RS00470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K5K99_RS00475	COG2827	Endonuclease containing a URI domain
K5K99_RS00485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K99_RS00490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5K99_RS00495	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5K99_RS00510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5K99_RS00530	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K99_RS00540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5K99_RS00545	COG0640	Transcriptional regulator
K5K99_RS00555	COG3878	Protein conserved in bacteria
K5K99_RS00560	COG2357	RelA SpoT domain protein
K5K99_RS00565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5K99_RS00570	COG2264	protein methyltransferase activity
K5K99_RS00580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5K99_RS00600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5K99_RS00605	COG0827	DNA restriction-modification system
K5K99_RS00635	COG4537	Required for transformation and DNA binding
K5K99_RS00645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5K99_RS00655	COG0217	transcriptional regulatory protein
K5K99_RS00685	COG1792	Involved in formation and maintenance of cell shape
K5K99_RS00690	COG1454	alcohol dehydrogenase
K5K99_RS00690	COG1012	belongs to the aldehyde dehydrogenase family
K5K99_RS00705	COG0343	queuine tRNA-ribosyltransferase activity
K5K99_RS00710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K5K99_RS00715	COG2255	four-way junction helicase activity
K5K99_RS00730	COG0424	maF-like protein
K5K99_RS00735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5K99_RS00740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5K99_RS00750	COG1692	metallophosphoesterase
K5K99_RS00770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5K99_RS00775	COG4684	Psort location CytoplasmicMembrane, score
K5K99_RS00800	COG3859	Proton-coupled thiamine transporter YuaJ
K5K99_RS00810	COG1309	transcriptional regulator
K5K99_RS00835	COG1132	(ABC) transporter
K5K99_RS00840	COG1132	(ABC) transporter
K5K99_RS00855	COG1011	Hydrolase
K5K99_RS00860	COG0789	Transcriptional regulator
K5K99_RS00865	COG4221	oxidoreductase activity
K5K99_RS00875	COG1803	Methylglyoxal synthase
K5K99_RS00880	COG3842	ATPase activity
K5K99_RS00890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K5K99_RS00895	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K5K99_RS00900	COG0084	hydrolase, TatD family'
K5K99_RS00905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K99_RS00905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K99_RS00915	COG1914	H( )-stimulated, divalent metal cation uptake system
K5K99_RS00925	COG3708	Transcriptional regulator
K5K99_RS00925	COG2207	Transcriptional regulator
K5K99_RS00930	COG0456	acetyltransferase
K5K99_RS00935	COG1418	mRNA catabolic process
K5K99_RS00940	COG0366	Alpha amylase catalytic
K5K99_RS00945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS00945	COG1263	PTS System
K5K99_RS00950	COG2188	Transcriptional regulator
K5K99_RS00955	COG0415	Belongs to the DNA photolyase family
K5K99_RS00960	COG1737	Transcriptional regulator
K5K99_RS00980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K5K99_RS00995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_RS01005	COG1053	succinate dehydrogenase
K5K99_RS01005	COG3976	FMN-binding domain protein
K5K99_RS01010	COG4607	ABC-type enterochelin transport system periplasmic component
K5K99_RS01015	COG4604	ABC transporter, ATP-binding protein
K5K99_RS01020	COG4605	iron ion homeostasis
K5K99_RS01025	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5K99_RS01030	COG5506	Protein of unknown function (DUF1694)
K5K99_RS01035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K5K99_RS01050	COG2188	Transcriptional regulator
K5K99_RS01055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_RS01060	COG2723	6-phospho-beta-galactosidase activity
K5K99_RS01065	COG2918	glutathione biosynthetic process
K5K99_RS01065	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K99_RS01070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_RS01070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_RS01070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_RS01075	COG1105	Belongs to the carbohydrate kinase PfkB family
K5K99_RS01080	COG1349	DNA-binding transcription factor activity
K5K99_RS01085	COG0552	protein localization to endoplasmic reticulum
K5K99_RS01090	COG0561	phosphatase activity
K5K99_RS01095	COG1196	nuclear chromosome segregation
K5K99_RS01100	COG0571	ribonuclease III activity
K5K99_RS01105	COG0747	negative chemotaxis
K5K99_RS01110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K99_RS01115	COG0601	transmembrane transport
K5K99_RS01120	COG4608	Belongs to the ABC transporter superfamily
K5K99_RS01130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K99_RS01135	COG0416	fatty acid biosynthetic process
K5K99_RS01140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5K99_RS01145	COG1461	Dihydroxyacetone kinase
K5K99_RS01155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5K99_RS01160	COG1564	THIamine pyrophosphokinase
K5K99_RS01165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5K99_RS01170	COG1162	GTPase activity
K5K99_RS01175	COG0515	serine threonine protein kinase
K5K99_RS01175	COG2815	serine threonine protein kinase
K5K99_RS01185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5K99_RS01185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5K99_RS01190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K5K99_RS01195	COG0242	peptide deformylase activity
K5K99_RS01200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5K99_RS01215	COG0384	phenazine biosynthesis protein PhzF
K5K99_RS01225	COG0194	GDP metabolic process
K5K99_RS01230	COG1561	YicC-like family, N-terminal region
K5K99_RS01250	COG0736	holo-[acyl-carrier-protein] synthase activity
K5K99_RS01260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5K99_RS01265	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K99_RS01275	COG3764	Sortase (surface protein transpeptidase)
K5K99_RS01280	COG3481	metal-dependent phosphohydrolase, HD sub domain
K5K99_RS01285	COG4717	serine-type aminopeptidase activity
K5K99_RS01295	COG3679	Belongs to the UPF0342 family
K5K99_RS01300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K99_RS01305	COG0564	pseudouridine synthase activity
K5K99_RS01330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5K99_RS01345	COG1438	arginine binding
K5K99_RS01350	COG1181	Belongs to the D-alanine--D-alanine ligase family
K5K99_RS01360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K99_RS01380	COG2814	Major facilitator Superfamily
K5K99_RS01390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5K99_RS01415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5K99_RS01435	COG3279	Response regulator of the LytR AlgR family
K5K99_RS01445	COG4166	transmembrane transport
K5K99_RS01455	COG1247	-acetyltransferase
K5K99_RS01465	COG0110	maltose O-acetyltransferase activity
K5K99_RS01475	COG0427	acetyl-CoA hydrolase
K5K99_RS01480	COG1024	Enoyl-CoA hydratase
K5K99_RS01485	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K99_RS01490	COG0183	Belongs to the thiolase family
K5K99_RS01495	COG0583	DNA-binding transcription factor activity
K5K99_RS01500	COG1960	acyl-CoA dehydrogenase activity
K5K99_RS01515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5K99_RS01520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5K99_RS01530	COG2323	membrane
K5K99_RS01540	COG2723	6-phospho-beta-galactosidase activity
K5K99_RS01545	COG1737	Transcriptional regulator
K5K99_RS01555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_RS01560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K99_RS01625	COG0400	carboxylic ester hydrolase activity
K5K99_RS01630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K5K99_RS01635	COG0346	lactoylglutathione lyase activity
K5K99_RS01640	COG0346	lactoylglutathione lyase activity
K5K99_RS01645	COG1846	Transcriptional regulator
K5K99_RS01665	COG2070	2-Nitropropane dioxygenase
K5K99_RS01675	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K5K99_RS01680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K5K99_RS01685	COG1024	Enoyl-CoA hydratase
K5K99_RS01690	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K99_RS01695	COG0183	Belongs to the thiolase family
K5K99_RS01700	COG0583	DNA-binding transcription factor activity
K5K99_RS01710	COG0346	lactoylglutathione lyase activity
K5K99_RS01720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5K99_RS01735	COG1304	FMN binding
K5K99_RS01740	COG1346	cytolysis
K5K99_RS01745	COG1380	Effector of murein hydrolase LrgA
K5K99_RS01760	COG1054	Belongs to the UPF0176 family
K5K99_RS01770	COG0604	alcohol dehydrogenase
K5K99_RS01780	COG0656	L-ascorbic acid biosynthetic process
K5K99_RS01785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K99_RS01830	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5K99_RS01855	COG0475	glutathione-regulated potassium exporter activity
K5K99_RS01885	COG3759	membrane
K5K99_RS01890	COG0778	Nitroreductase
K5K99_RS01895	COG1846	Transcriptional regulator
K5K99_RS01910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5K99_RS01935	COG1309	transcriptional regulator
K5K99_RS01940	COG2723	6-phospho-beta-galactosidase activity
K5K99_RS01945	COG1263	PTS System
K5K99_RS01945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS01945	COG2190	(PTS) system
K5K99_RS01950	COG3711	transcriptional antiterminator
K5K99_RS02035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K5K99_RS02040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K5K99_RS02055	COG1122	ATPase activity
K5K99_RS02060	COG1122	ATPase activity
K5K99_RS02065	COG0203	ribosomal protein L17
K5K99_RS02070	COG0202	RNA polymerase activity
K5K99_RS02075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5K99_RS02080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5K99_RS02085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5K99_RS02090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5K99_RS02095	COG0563	adenylate kinase activity
K5K99_RS02105	COG0200	Binds to the 23S rRNA
K5K99_RS02110	COG1841	ribosomal large subunit assembly
K5K99_RS02115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K5K99_RS02125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5K99_RS02130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K5K99_RS02135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5K99_RS02140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5K99_RS02145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5K99_RS02150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5K99_RS02155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5K99_RS02160	COG0255	Belongs to the universal ribosomal protein uL29 family
K5K99_RS02165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K5K99_RS02170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5K99_RS02175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K5K99_RS02180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5K99_RS02185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5K99_RS02190	COG0089	rRNA binding
K5K99_RS02195	COG0088	Forms part of the polypeptide exit tunnel
K5K99_RS02200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5K99_RS02205	COG0051	transcription antitermination factor activity, RNA binding
K5K99_RS02215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5K99_RS02220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5K99_RS02225	COG0049	tRNA binding
K5K99_RS02230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K5K99_RS02235	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K5K99_RS02240	COG0588	phosphoglycerate mutase activity
K5K99_RS02260	COG1114	Component of the transport system for branched-chain amino acids
K5K99_RS02425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5K99_RS02435	COG0517	IMP dehydrogenase activity
K5K99_RS02435	COG0516	GMP reductase activity
K5K99_RS02445	COG0012	GTP binding
K5K99_RS02450	COG4481	Protein conserved in bacteria
K5K99_RS02455	COG1475	DNA binding
K5K99_RS02460	COG1192	Involved in chromosome partitioning
K5K99_RS02465	COG0357	Ribosomal RNA small subunit methyltransferase G
K5K99_RS02480	COG0445	tRNA wobble uridine modification
K5K99_RS02485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K5K99_RS02490	COG2153	protein acetylation
K5K99_RS02495	COG0018	arginyl-trna synthetase
K5K99_RS02505	COG0706	membrane insertase activity
K5K99_RS02510	COG0594	ribonuclease P activity
K5K99_RS02515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K5K99_RS02520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5K99_RS02525	COG0592	DNA-directed DNA polymerase activity
K5K99_RS02535	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5K99_RS02540	COG0187	DNA topoisomerase II activity
K5K99_RS02550	COG0360	Binds together with S18 to 16S ribosomal RNA
K5K99_RS02555	COG0629	single-stranded DNA binding
K5K99_RS02560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K5K99_RS02565	COG0359	binds to the 23S rRNA
K5K99_RS02570	COG0305	Participates in initiation and elongation during chromosome replication
K5K99_RS02575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5K99_RS02595	COG0488	(ABC) transporter
K5K99_RS02610	COG0142	geranyltranstransferase activity
K5K99_RS02625	COG4939	FMN-binding domain protein
K5K99_RS02645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K5K99_RS02660	COG1609	Transcriptional regulator
K5K99_RS02665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K5K99_RS02675	COG1744	ABC transporter substrate-binding protein PnrA-like
K5K99_RS02680	COG3845	ABC transporter
K5K99_RS02685	COG4603	Belongs to the binding-protein-dependent transport system permease family
K5K99_RS02690	COG1079	Belongs to the binding-protein-dependent transport system permease family
K5K99_RS02695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K5K99_RS02705	COG0813	purine-nucleoside phosphorylase activity
K5K99_RS02725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K5K99_RS02730	COG0477	Major facilitator Superfamily
K5K99_RS02745	COG1686	Belongs to the peptidase S11 family
K5K99_RS02750	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K5K99_RS02755	COG1242	4 iron, 4 sulfur cluster binding
K5K99_RS02760	COG0671	phosphoesterase, PA-phosphatase related
K5K99_RS02775	COG1388	LysM domain
K5K99_RS02775	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K99_RS02780	COG0495	leucyl-tRNA aminoacylation
K5K99_RS02785	COG2244	polysaccharide biosynthetic process
K5K99_RS02790	COG1187	pseudouridine synthase activity
K5K99_RS02795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K99_RS02815	COG1126	abc transporter atp-binding protein
K5K99_RS02820	COG0765	amino acid transport
K5K99_RS02830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5K99_RS02840	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5K99_RS02860	COG0395	ABC-type sugar transport system, permease component
K5K99_RS02870	COG1554	hydrolase, family 65, central catalytic
K5K99_RS02875	COG1609	Transcriptional regulator
K5K99_RS02885	COG0366	Alpha amylase catalytic
K5K99_RS02890	COG1653	transport
K5K99_RS02895	COG1175	transmembrane transport
K5K99_RS02900	COG0395	ABC-type sugar transport system, permease component
K5K99_RS02905	COG3842	ATPase activity
K5K99_RS02925	COG5294	Protein conserved in bacteria
K5K99_RS02975	COG3620	sequence-specific DNA binding
K5K99_RS02980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5K99_RS03015	COG3328	transposase activity
K5K99_RS03030	COG3328	transposase activity
K5K99_RS03035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K5K99_RS03055	COG0659	secondary active sulfate transmembrane transporter activity
K5K99_RS03060	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K99_RS03070	COG1269	ATP hydrolysis coupled proton transport
K5K99_RS03075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K99_RS03085	COG1527	subunit (C
K5K99_RS03090	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
K5K99_RS03095	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K5K99_RS03100	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
K5K99_RS03105	COG1394	ATPase activity, coupled to movement of substances
K5K99_RS03115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5K99_RS03120	COG3328	transposase activity
K5K99_RS03135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5K99_RS03145	COG0039	L-malate dehydrogenase activity
K5K99_RS03150	COG0193	aminoacyl-tRNA hydrolase activity
K5K99_RS03155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5K99_RS03160	COG2244	polysaccharide biosynthetic process
K5K99_RS03165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K5K99_RS03175	COG1098	S1 RNA binding domain
K5K99_RS03180	COG0037	tRNA processing
K5K99_RS03185	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K5K99_RS03190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5K99_RS03195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5K99_RS03200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5K99_RS03205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K5K99_RS03280	COG3620	sequence-specific DNA binding
K5K99_RS03385	COG4463	regulation of RNA biosynthetic process
K5K99_RS03390	COG0542	response to heat
K5K99_RS03400	COG0826	peptidase U32
K5K99_RS03405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K99_RS03410	COG1271	oxidase subunit
K5K99_RS03415	COG1294	oxidase, subunit
K5K99_RS03420	COG4988	ABC transporter
K5K99_RS03425	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K5K99_RS03440	COG1054	Belongs to the UPF0176 family
K5K99_RS03490	COG0363	glucosamine-6-phosphate deaminase activity
K5K99_RS03495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5K99_RS03525	COG0798	PFAM Bile acid sodium symporter
K5K99_RS03585	COG1442	glycosyl transferase family 8
K5K99_RS03605	COG0640	Transcriptional regulator
K5K99_RS03610	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5K99_RS03640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K5K99_RS03650	COG1609	Transcriptional regulator
K5K99_RS03665	COG0488	(ABC) transporter
K5K99_RS03670	COG0488	(ABC) transporter
K5K99_RS03675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K5K99_RS03690	COG0628	permease
K5K99_RS03705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5K99_RS03710	COG1426	Protein conserved in bacteria
K5K99_RS03715	COG0300	oxidoreductase activity
K5K99_RS03720	COG0612	Peptidase, M16
K5K99_RS03725	COG0612	Peptidase, M16
K5K99_RS03730	COG1970	mechanosensitive ion channel activity
K5K99_RS03735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K5K99_RS03745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K99_RS03750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5K99_RS03755	COG1121	(ABC) transporter
K5K99_RS03760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K5K99_RS03770	COG1177	transmembrane transport
K5K99_RS03775	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5K99_RS03780	COG3842	ATPase activity
K5K99_RS03790	COG0604	alcohol dehydrogenase
K5K99_RS03845	COG1473	amidohydrolase
K5K99_RS03850	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K5K99_RS03855	COG0038	chloride channel
K5K99_RS03865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5K99_RS03870	COG4565	transcriptional regulatory protein
K5K99_RS03875	COG3290	protein histidine kinase activity
K5K99_RS03880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5K99_RS03885	COG0708	Exodeoxyribonuclease III
K5K99_RS03905	COG0802	atpase or kinase
K5K99_RS03915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5K99_RS03925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS03925	COG1263	PTS System
K5K99_RS03925	COG2190	(PTS) system
K5K99_RS03935	COG1609	Transcriptional regulator
K5K99_RS03945	COG0280	phosphate acetyltransferase
K5K99_RS03955	COG0561	phosphatase activity
K5K99_RS03965	COG0025	NhaP-type Na H and K H
K5K99_RS03970	COG1278	Cold shock
K5K99_RS03990	COG0745	RESPONSE REGULATOR receiver
K5K99_RS03995	COG5002	protein histidine kinase activity
K5K99_RS04000	COG2433	Pfam Transposase IS66
K5K99_RS04025	COG1131	(ABC) transporter
K5K99_RS04070	COG1215	transferase activity, transferring glycosyl groups
K5K99_RS04080	COG2188	Transcriptional regulator
K5K99_RS04105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K5K99_RS04135	COG1285	pathogenesis
K5K99_RS04140	COG0251	oxidation-reduction process
K5K99_RS04160	COG2390	Transcriptional regulator
K5K99_RS04165	COG0583	DNA-binding transcription factor activity
K5K99_RS04170	COG4166	transmembrane transport
K5K99_RS04175	COG0402	S-adenosylhomocysteine deaminase activity
K5K99_RS04180	COG0402	S-adenosylhomocysteine deaminase activity
K5K99_RS04185	COG4335	DNA alkylation repair
K5K99_RS04210	COG3448	diguanylate cyclase activity
K5K99_RS04210	COG4175	Glycine betaine
K5K99_RS04235	COG1175	transmembrane transport
K5K99_RS04240	COG0395	ABC-type sugar transport system, permease component
K5K99_RS04245	COG3250	beta-galactosidase activity
K5K99_RS04260	COG1609	Transcriptional regulator
K5K99_RS04270	COG1132	(ABC) transporter
K5K99_RS04275	COG1132	(ABC) transporter
K5K99_RS04280	COG0765	amino acid transport
K5K99_RS04285	COG1126	abc transporter atp-binding protein
K5K99_RS04290	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K5K99_RS04300	COG0435	Glutathione S-transferase
K5K99_RS04310	COG3022	response to hydroperoxide
K5K99_RS04315	COG2252	PERMEase
K5K99_RS04340	COG5504	Zn-dependent protease
K5K99_RS04345	COG2723	6-phospho-beta-galactosidase activity
K5K99_RS04350	COG1940	carbohydrate kinase activity
K5K99_RS04360	COG3973	AAA domain
K5K99_RS04380	COG0531	amino acid
K5K99_RS04390	COG1757	Na H antiporter
K5K99_RS04410	COG4166	transmembrane transport
K5K99_RS04425	COG1136	(ABC) transporter
K5K99_RS04430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5K99_RS04430	COG0519	Catalyzes the synthesis of GMP from XMP
K5K99_RS04435	COG1072	(Pantothenic acid kinase))
K5K99_RS04440	COG2755	lipolytic protein G-D-S-L family
K5K99_RS04445	COG2813	Specifically methylates the guanine in position
K5K99_RS04450	COG0085	RNA polymerase activity
K5K99_RS04455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5K99_RS04470	COG3711	transcriptional antiterminator
K5K99_RS04475	COG1263	PTS System
K5K99_RS04475	COG2190	(PTS) system
K5K99_RS04475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS04480	COG2723	6-phospho-beta-galactosidase activity
K5K99_RS04495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5K99_RS04500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K5K99_RS04510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5K99_RS04520	COG3158	transport of potassium into the cell
K5K99_RS04525	COG0756	dUTP diphosphatase activity
K5K99_RS04535	COG4956	integral membrane protein (PIN domain superfamily)
K5K99_RS04540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5K99_RS04545	COG1045	serine acetyltransferase
K5K99_RS04550	COG0215	cysteine-tRNA ligase activity
K5K99_RS04555	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K5K99_RS04560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5K99_RS04565	COG3688	RNA-binding protein containing a PIN domain
K5K99_RS04575	COG4466	Protein conserved in bacteria
K5K99_RS04580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5K99_RS04585	COG4980	gas vesicle protein
K5K99_RS04590	COG0537	adenosine 5'-monophosphoramidase activity
K5K99_RS04595	COG1131	(ABC) transporter
K5K99_RS04600	COG4473	ABC transporter
K5K99_RS04605	COG0510	thiamine kinase activity
K5K99_RS04610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5K99_RS04615	COG1611	Belongs to the LOG family
K5K99_RS04620	COG1694	Mazg nucleotide pyrophosphohydrolase
K5K99_RS04635	COG1363	Peptidase, m42
K5K99_RS04640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K99_RS04650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K99_RS04655	COG4472	Bacterial protein of unknown function (DUF965)
K5K99_RS04660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5K99_RS04675	COG3906	Belongs to the UPF0473 family
K5K99_RS04680	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5K99_RS04695	COG1193	negative regulation of DNA recombination
K5K99_RS04700	COG3118	belongs to the thioredoxin family
K5K99_RS04705	COG0322	excinuclease ABC activity
K5K99_RS04730	COG4152	abc transporter atp-binding protein
K5K99_RS04735	COG1668	transmembrane transport
K5K99_RS04745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5K99_RS04750	COG2116	formate transmembrane transporter activity
K5K99_RS04755	COG0561	phosphatase activity
K5K99_RS04760	COG0242	peptide deformylase activity
K5K99_RS04765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5K99_RS04770	COG1185	polyribonucleotide nucleotidyltransferase activity
K5K99_RS04785	COG0383	alpha-mannosidase activity
K5K99_RS04795	COG1609	Transcriptional regulator
K5K99_RS04805	COG1940	carbohydrate kinase activity
K5K99_RS04815	COG1649	PFAM Uncharacterised BCR, COG1649
K5K99_RS04830	COG1309	transcriptional regulator
K5K99_RS04835	COG2376	Dihydroxyacetone kinase
K5K99_RS04840	COG1461	Dihydroxyacetone kinase
K5K99_RS04845	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
K5K99_RS04850	COG0371	Dehydrogenase
K5K99_RS04855	COG2376	Dihydroxyacetone kinase
K5K99_RS04895	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K5K99_RS04900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5K99_RS04905	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5K99_RS04910	COG0028	Belongs to the TPP enzyme family
K5K99_RS04920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K99_RS04925	COG2011	ABC-type metal ion transport system permease component
K5K99_RS04960	COG0642	Histidine kinase
K5K99_RS04970	COG1136	(ABC) transporter
K5K99_RS04975	COG0577	efflux transmembrane transporter activity
K5K99_RS04980	COG1363	Peptidase, m42
K5K99_RS04995	COG0577	efflux transmembrane transporter activity
K5K99_RS05000	COG1234	tRNA 3'-trailer cleavage
K5K99_RS05005	COG0095	Lipoate-protein ligase
K5K99_RS05010	COG0740	serine-type endopeptidase activity
K5K99_RS05015	COG0180	Tryptophanyl-tRNA synthetase
K5K99_RS05020	COG1393	Belongs to the ArsC family
K5K99_RS05025	COG4862	establishment of competence for transformation
K5K99_RS05035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K99_RS05040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5K99_RS05045	COG1780	Probably involved in ribonucleotide reductase function
K5K99_RS05050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5K99_RS05070	COG0582	viral genome integration into host DNA
K5K99_RS05095	COG1396	sequence-specific DNA binding
K5K99_RS05335	COG3953	SLT domain
K5K99_RS05335	COG5412	phage tail tape measure protein
K5K99_RS05385	COG0745	RESPONSE REGULATOR receiver
K5K99_RS05390	COG5002	protein histidine kinase activity
K5K99_RS05405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K5K99_RS05410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5K99_RS05415	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K5K99_RS05420	COG0582	viral genome integration into host DNA
K5K99_RS05430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5K99_RS05435	COG1396	sequence-specific DNA binding
K5K99_RS05735	COG2003	Belongs to the UPF0758 family
K5K99_RS05795	COG1573	uracil-dna glycosylase
K5K99_RS05820	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K5K99_RS05825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5K99_RS05835	COG4166	transmembrane transport
K5K99_RS05850	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K5K99_RS05855	COG1175	transmembrane transport
K5K99_RS05860	COG0395	ABC-type sugar transport system, permease component
K5K99_RS05880	COG1737	Transcriptional regulator
K5K99_RS05885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5K99_RS05890	COG4166	transmembrane transport
K5K99_RS05900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5K99_RS05905	COG0626	cystathionine gamma-synthase activity
K5K99_RS05930	COG0673	inositol 2-dehydrogenase activity
K5K99_RS05940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K99_RS05945	COG1609	Transcriptional regulator
K5K99_RS05955	COG1175	transmembrane transport
K5K99_RS05960	COG0395	ABC-type sugar transport system, permease component
K5K99_RS05965	COG1621	beta-fructofuranosidase activity
K5K99_RS05970	COG1940	carbohydrate kinase activity
K5K99_RS05980	COG1737	Transcriptional regulator
K5K99_RS05985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_RS05990	COG2723	6-phospho-beta-galactosidase activity
K5K99_RS05995	COG1940	carbohydrate kinase activity
K5K99_RS06000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_RS06005	COG2188	Transcriptional regulator
K5K99_RS06010	COG2723	6-phospho-beta-galactosidase activity
K5K99_RS06025	COG0789	Transcriptional regulator
K5K99_RS06030	COG0667	Aldo Keto reductase
K5K99_RS06035	COG1846	Transcriptional regulator
K5K99_RS06040	COG2814	Major facilitator Superfamily
K5K99_RS06045	COG1132	(ABC) transporter
K5K99_RS06060	COG0745	RESPONSE REGULATOR receiver
K5K99_RS06065	COG1414	Transcriptional regulator
K5K99_RS06070	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K5K99_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
K5K99_RS06085	COG0800	Aldolase
K5K99_RS06100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5K99_RS06100	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5K99_RS06105	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K5K99_RS06110	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS06115	COG3715	PTS system
K5K99_RS06145	COG1105	Belongs to the carbohydrate kinase PfkB family
K5K99_RS06150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_RS06150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_RS06150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_RS06155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_RS06155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_RS06155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_RS06160	COG3684	Belongs to the aldolase LacD family
K5K99_RS06170	COG3716	PTS system mannose fructose sorbose family IID component
K5K99_RS06175	COG2188	Transcriptional regulator
K5K99_RS06180	COG2222	sugar isomerase
K5K99_RS06185	COG3684	Belongs to the aldolase LacD family
K5K99_RS06190	COG1105	Belongs to the carbohydrate kinase PfkB family
K5K99_RS06195	COG1187	pseudouridine synthase activity
K5K99_RS06200	COG0217	transcriptional regulatory protein
K5K99_RS06210	COG1132	(ABC) transporter
K5K99_RS06215	COG1132	(ABC) transporter
K5K99_RS06225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K5K99_RS06245	COG0641	radical SAM
K5K99_RS06255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K5K99_RS06260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5K99_RS06275	COG0395	ABC-type sugar transport system, permease component
K5K99_RS06280	COG1175	transmembrane transport
K5K99_RS06290	COG0564	pseudouridine synthase activity
K5K99_RS06295	COG4684	Psort location CytoplasmicMembrane, score
K5K99_RS06315	COG3730	PTS system glucitol sorbitol-specific
K5K99_RS06320	COG3732	PTS system glucitol sorbitol-specific
K5K99_RS06335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5K99_RS06345	COG0604	alcohol dehydrogenase
K5K99_RS06365	COG2169	Transcriptional regulator
K5K99_RS06375	COG0698	ribose 5-phosphate isomerase
K5K99_RS06390	COG3775	system Galactitol-specific IIC component
K5K99_RS06395	COG0235	Class ii aldolase
K5K99_RS06400	COG3414	Phosphotransferase system galactitol-specific IIB component
K5K99_RS06405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K99_RS06410	COG0022	dehydrogenase e1 component
K5K99_RS06440	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K5K99_RS06450	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K5K99_RS06455	COG0352	thiamine-phosphate diphosphorylase activity
K5K99_RS06460	COG0351	phosphomethylpyrimidine kinase
K5K99_RS06465	COG0531	amino acid
K5K99_RS06470	COG0662	Cupin 2, conserved barrel domain protein
K5K99_RS06500	COG3639	organic phosphonate transmembrane transporter activity
K5K99_RS06505	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K5K99_RS06515	COG1695	Transcriptional regulator
K5K99_RS06520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_RS06535	COG0159	tryptophan synthase activity
K5K99_RS06560	COG0513	Belongs to the DEAD box helicase family
K5K99_RS06565	COG0105	UTP biosynthetic process
K5K99_RS06575	COG5002	protein histidine kinase activity
K5K99_RS06595	COG0431	NADPH-dependent FMN reductase
K5K99_RS06595	COG3976	FMN-binding domain protein
K5K99_RS06595	COG1053	succinate dehydrogenase
K5K99_RS06605	COG0714	Associated with various cellular activities
K5K99_RS06615	COG1305	Transglutaminase-like
K5K99_RS06625	COG1609	Transcriptional regulator
K5K99_RS06635	COG1869	D-ribose catabolic process
K5K99_RS06640	COG4975	Glucose uptake
K5K99_RS06675	COG1263	PTS System
K5K99_RS06675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS06675	COG2190	(PTS) system
K5K99_RS06680	COG3711	transcriptional antiterminator
K5K99_RS06685	COG2213	PTS system mannitol-specific
K5K99_RS06690	COG3711	transcriptional antiterminator
K5K99_RS06695	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_RS06700	COG2213	PTS system mannitol-specific
K5K99_RS06705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_RS06710	COG0246	Mannitol dehydrogenase
K5K99_RS06775	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K5K99_RS06780	COG1609	Transcriptional regulator
K5K99_RS06785	COG2017	converts alpha-aldose to the beta-anomer
K5K99_RS06790	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5K99_RS06795	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K5K99_RS06800	COG1609	Transcriptional regulator
K5K99_RS06820	COG0745	RESPONSE REGULATOR receiver
K5K99_RS06830	COG0367	asparagine synthase
K5K99_RS06850	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K5K99_RS06860	COG1506	peptidase
K5K99_RS06860	COG4946	Tricorn protease homolog
K5K99_RS06860	COG0823	Involved in the tonB-independent uptake of proteins
K5K99_RS06870	COG1126	abc transporter atp-binding protein
K5K99_RS06875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K99_RS06880	COG0765	amino acid transport
K5K99_RS06885	COG0765	amino acid transport
K5K99_RS06895	COG1268	BioY protein
K5K99_RS06905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K99_RS06910	COG2011	ABC-type metal ion transport system permease component
K5K99_RS06915	COG1464	Belongs to the NlpA lipoprotein family
K5K99_RS06925	COG1486	melibiose metabolic process
K5K99_RS06930	COG1609	Transcriptional regulator
K5K99_RS06945	COG3404	Formiminotransferase-cyclodeaminase
K5K99_RS06950	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K5K99_RS06960	COG0531	amino acid
K5K99_RS06970	COG0124	histidyl-tRNA synthetase
K5K99_RS06975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K99_RS06980	COG0456	acetyltransferase
K5K99_RS06985	COG1597	lipid kinase activity
K5K99_RS06990	COG1228	amidohydrolase
K5K99_RS06995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K5K99_RS07020	COG1070	Carbohydrate kinase
K5K99_RS07025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5K99_RS07030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5K99_RS07035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5K99_RS07050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5K99_RS07055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5K99_RS07065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5K99_RS07075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5K99_RS07080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5K99_RS07085	COG0138	bifunctional purine biosynthesis protein purh
K5K99_RS07100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5K99_RS07105	COG1534	Rna-binding protein
K5K99_RS07110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5K99_RS07120	COG0799	negative regulation of ribosome biogenesis
K5K99_RS07125	COG2226	methyltransferase
K5K99_RS07130	COG1323	Belongs to the UPF0348 family
K5K99_RS07150	COG3655	Transcriptional regulator
K5K99_RS07155	COG1304	FMN binding
K5K99_RS07170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K5K99_RS07175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5K99_RS07180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5K99_RS07195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5K99_RS07200	COG1121	(ABC) transporter
K5K99_RS07205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5K99_RS07220	COG0300	oxidoreductase activity
K5K99_RS07230	COG0772	Belongs to the SEDS family
K5K99_RS07240	COG1393	Belongs to the ArsC family
K5K99_RS07245	COG0509	glycine decarboxylation via glycine cleavage system
K5K99_RS07250	COG0716	FMN binding
K5K99_RS07260	COG3706	GGDEF domain
K5K99_RS07270	COG2738	Putative neutral zinc metallopeptidase
K5K99_RS07275	COG2508	Transcriptional regulator
K5K99_RS07280	COG0590	tRNA wobble adenosine to inosine editing
K5K99_RS07290	COG1428	Deoxynucleoside kinase
K5K99_RS07315	COG1653	transport
K5K99_RS07320	COG1175	transmembrane transport
K5K99_RS07325	COG0395	ABC-type sugar transport system, permease component
K5K99_RS07330	COG0366	Alpha amylase catalytic
K5K99_RS07335	COG1960	acyl-CoA dehydrogenase activity
K5K99_RS07340	COG0583	DNA-binding transcription factor activity
K5K99_RS07345	COG0183	Belongs to the thiolase family
K5K99_RS07350	COG1960	acyl-CoA dehydrogenase activity
K5K99_RS07355	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5K99_RS07360	COG1024	Enoyl-CoA hydratase
K5K99_RS07365	COG0427	acetyl-CoA hydrolase
K5K99_RS07370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5K99_RS07375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5K99_RS07380	COG0351	phosphomethylpyrimidine kinase
K5K99_RS07385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K99_RS07420	COG0504	CTP synthase activity
K5K99_RS07445	COG1335	isochorismatase
K5K99_RS07450	COG1522	sequence-specific DNA binding
K5K99_RS07460	COG0681	Belongs to the peptidase S26 family
K5K99_RS07470	COG1136	(ABC) transporter
K5K99_RS07470	COG0577	efflux transmembrane transporter activity
K5K99_RS07475	COG0577	efflux transmembrane transporter activity
K5K99_RS07475	COG1136	(ABC) transporter
K5K99_RS07490	COG3425	synthase
K5K99_RS07495	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5K99_RS07500	COG1363	Peptidase, m42
K5K99_RS07515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K5K99_RS07530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_RS07545	COG2807	transmembrane transport
K5K99_RS07550	COG1396	sequence-specific DNA binding
K5K99_RS07570	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K5K99_RS07575	COG1074	ATP-dependent DNA helicase activity
K5K99_RS07590	COG3853	Toxic anion resistance protein (TelA)
K5K99_RS07595	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
K5K99_RS07610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5K99_RS07615	COG1335	isochorismatase
K5K99_RS07620	COG2855	membrane
K5K99_RS07635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5K99_RS07640	COG2706	6-phosphogluconolactonase activity
K5K99_RS07650	COG0628	permease
K5K99_RS07655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K5K99_RS07660	COG1435	thymidine kinase activity
K5K99_RS07665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5K99_RS07670	COG2890	protein-(glutamine-N5) methyltransferase activity
K5K99_RS07675	COG0009	L-threonylcarbamoyladenylate synthase
K5K99_RS07680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5K99_RS07685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5K99_RS07700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5K99_RS07705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K99_RS07725	COG0116	Belongs to the methyltransferase superfamily
K5K99_RS07730	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K5K99_RS07735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5K99_RS07740	COG3588	fructose-bisphosphate aldolase
K5K99_RS07745	COG2188	Transcriptional regulator
K5K99_RS07750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_RS07765	COG3964	amidohydrolase
K5K99_RS07785	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5K99_RS07800	COG1131	(ABC) transporter
K5K99_RS07810	COG2365	Tyrosine phosphatase family
K5K99_RS07815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5K99_RS07820	COG0737	Belongs to the 5'-nucleotidase family
K5K99_RS07825	COG4470	Protein conserved in bacteria
K5K99_RS07830	COG0647	UMP catabolic process
K5K99_RS07845	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K5K99_RS07850	COG0492	ferredoxin-NADP+ reductase activity
K5K99_RS07865	COG1132	(ABC) transporter
K5K99_RS07880	COG1482	cell wall glycoprotein biosynthetic process
K5K99_RS07885	COG1609	Transcriptional regulator
K5K99_RS07890	COG0686	Belongs to the AlaDH PNT family
K5K99_RS07895	COG3442	glutamine amidotransferase
K5K99_RS07900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5K99_RS07910	COG0601	transmembrane transport
K5K99_RS07915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K99_RS07920	COG0444	Belongs to the ABC transporter superfamily
K5K99_RS07925	COG4608	Belongs to the ABC transporter superfamily
K5K99_RS07935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5K99_RS07950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5K99_RS07955	COG0328	RNA-DNA hybrid ribonuclease activity
K5K99_RS07965	COG1278	Cold shock
K5K99_RS07970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K5K99_RS07975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5K99_RS07980	COG0735	belongs to the Fur family
K5K99_RS08105	COG1696	Membrane protein involved in D-alanine export
K5K99_RS08110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K99_RS08115	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K5K99_RS08130	COG2391	methyltransferase activity
K5K99_RS08135	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K99_RS08140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5K99_RS08145	COG4521	taurine ABC transporter
K5K99_RS08150	COG1116	anion transmembrane transporter activity
K5K99_RS08155	COG0741	lytic transglycosylase activity
K5K99_RS08160	COG0726	polysaccharide deacetylase
K5K99_RS08165	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K5K99_RS08165	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K5K99_RS08170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K99_RS08175	COG1175	transmembrane transport
K5K99_RS08180	COG0395	ABC-type sugar transport system, permease component
K5K99_RS08185	COG1653	transport
K5K99_RS08195	COG2972	Histidine kinase
K5K99_RS08200	COG2207	Transcriptional regulator
K5K99_RS08200	COG4753	response regulator
K5K99_RS08215	COG2824	Alkylphosphonate utilization operon protein PhnA
K5K99_RS08220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5K99_RS08225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5K99_RS08235	COG4585	Histidine kinase
K5K99_RS08240	COG2197	response regulator
K5K99_RS08245	COG0569	domain protein
K5K99_RS08250	COG4841	protein insertion into membrane
K5K99_RS08260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K5K99_RS08265	COG4838	Belongs to the UPF0358 family
K5K99_RS08270	COG0772	Belongs to the SEDS family
K5K99_RS08275	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K5K99_RS08290	COG4471	UPF0298 protein
K5K99_RS08300	COG0488	(ABC) transporter
K5K99_RS08310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5K99_RS08315	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K5K99_RS08320	COG1253	flavin adenine dinucleotide binding
K5K99_RS08325	COG0494	nUDIX hydrolase
K5K99_RS08330	COG1214	PFAM Peptidase M22, glycoprotease
K5K99_RS08340	COG0456	acetyltransferase
K5K99_RS08345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5K99_RS08360	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5K99_RS08375	COG1473	amidohydrolase
K5K99_RS08380	COG0668	transmembrane transport
K5K99_RS08395	COG1609	Transcriptional regulator
K5K99_RS08400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5K99_RS08405	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K5K99_RS08410	COG3763	UPF0154 protein
K5K99_RS08415	COG1132	(ABC) transporter
K5K99_RS08420	COG1132	(ABC) transporter
K5K99_RS08430	COG1609	Transcriptional regulator
K5K99_RS08435	COG0366	Alpha amylase catalytic
K5K99_RS08445	COG2182	Extracellular solute-binding protein
K5K99_RS08450	COG1175	transmembrane transport
K5K99_RS08455	COG3833	ABC-type maltose transport systems, permease component
K5K99_RS08470	COG0534	Mate efflux family protein
K5K99_RS08480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5K99_RS08485	COG0640	Transcriptional regulator
K5K99_RS08495	COG0083	homoserine kinase activity
K5K99_RS08510	COG1254	Belongs to the acylphosphatase family
K5K99_RS08515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5K99_RS08525	COG1733	regulation of RNA biosynthetic process
K5K99_RS08530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K5K99_RS08535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5K99_RS08535	COG0072	phenylalanine-tRNA ligase activity
K5K99_RS08540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5K99_RS08545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5K99_RS08550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K99_RS08560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5K99_RS08565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K5K99_RS08575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5K99_RS08585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5K99_RS08595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5K99_RS08600	COG0439	Biotin carboxylase
K5K99_RS08605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K5K99_RS08610	COG0825	malonyl-CoA metabolic process
K5K99_RS08620	COG2151	metal-sulfur cluster biosynthetic enzyme
K5K99_RS08660	COG1523	belongs to the glycosyl hydrolase 13 family
K5K99_RS08665	COG2267	carboxylic ester hydrolase activity
K5K99_RS08685	COG3328	transposase activity
K5K99_RS08720	COG5566	PFAM Mor transcription activator
K5K99_RS08725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5K99_RS08730	COG1073	alpha beta
K5K99_RS08735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5K99_RS08795	COG0745	RESPONSE REGULATOR receiver
K5K99_RS08800	COG3850	Histidine kinase
K5K99_RS08800	COG5002	protein histidine kinase activity
K5K99_RS08805	COG4476	Belongs to the UPF0223 family
K5K99_RS08810	COG0483	inositol monophosphate 1-phosphatase activity
K5K99_RS08815	COG1217	gtp-binding protein TYPA
K5K99_RS08830	COG0210	DNA helicase
K5K99_RS08835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5K99_RS08840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5K99_RS08845	COG0154	amidase activity
K5K99_RS08850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K5K99_RS08855	COG1597	lipid kinase activity
K5K99_RS08860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5K99_RS08895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K99_RS08910	COG2608	mercury ion transmembrane transporter activity
K5K99_RS08935	COG3328	transposase activity
K5K99_RS08945	COG1136	(ABC) transporter
K5K99_RS08960	COG5002	protein histidine kinase activity
K5K99_RS09015	COG2030	dehydratase
K5K99_RS09030	COG1368	sulfuric ester hydrolase activity
K5K99_RS09035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K5K99_RS09040	COG0710	3-dehydroquinate dehydratase activity
K5K99_RS09045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5K99_RS09050	COG2081	HI0933 family
K5K99_RS09055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K5K99_RS09060	COG0166	Belongs to the GPI family
K5K99_RS09085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5K99_RS09095	COG0670	Belongs to the BI1 family
K5K99_RS09100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5K99_RS09100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5K99_RS09105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5K99_RS09110	COG0237	dephospho-CoA kinase activity
K5K99_RS09115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5K99_RS09125	COG1484	DNA-dependent DNA replication
K5K99_RS09135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5K99_RS09140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K5K99_RS09160	COG0765	amino acid transport
K5K99_RS09165	COG1126	abc transporter atp-binding protein
K5K99_RS09170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5K99_RS09195	COG0737	Belongs to the 5'-nucleotidase family
K5K99_RS09215	COG0187	DNA topoisomerase II activity
K5K99_RS09220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5K99_RS09225	COG1882	Formate acetyltransferase
K5K99_RS09230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5K99_RS09245	COG2076	Multidrug Resistance protein
K5K99_RS09250	COG2076	Multidrug Resistance protein
K5K99_RS09255	COG1227	inorganic diphosphatase activity
K5K99_RS09265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5K99_RS09275	COG0564	pseudouridine synthase activity
K5K99_RS09285	COG2233	PERMEase
K5K99_RS09290	COG0540	Belongs to the ATCase OTCase family
K5K99_RS09295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5K99_RS09300	COG0505	Belongs to the CarA family
K5K99_RS09305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5K99_RS09310	COG0543	2 iron, 2 sulfur cluster binding
K5K99_RS09315	COG0167	dihydroorotate dehydrogenase activity
K5K99_RS09320	COG0284	orotidine-5'-phosphate decarboxylase activity
K5K99_RS09355	COG1278	Cold shock
K5K99_RS09360	COG0531	amino acid
K5K99_RS09370	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K5K99_RS09390	COG4120	Belongs to the binding-protein-dependent transport system permease family
K5K99_RS09395	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K5K99_RS09425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K99_RS09435	COG3328	transposase activity
K5K99_RS09460	COG0577	efflux transmembrane transporter activity
K5K99_RS09460	COG0577	efflux transmembrane transporter activity
K5K99_RS09460	COG1136	(ABC) transporter
K5K99_RS09460	COG1136	(ABC) transporter
K5K99_RS09465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5K99_RS09480	COG0768	penicillin binding
K5K99_RS09485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5K99_RS09490	COG1472	Belongs to the glycosyl hydrolase 3 family
K5K99_RS09505	COG4895	conserved protein (DUF2196)
K5K99_RS09570	COG0481	GTPase activity
K5K99_RS09580	COG0542	response to heat
K5K99_RS09590	COG0463	Glycosyl transferase, family 2
K5K99_RS09600	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5K99_RS09605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5K99_RS09610	COG2384	SAM-dependent methyltransferase
K5K99_RS09615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5K99_RS09620	COG0358	DNA primase activity
K5K99_RS09625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K99_RS09630	COG0515	serine threonine protein kinase
K5K99_RS09635	COG1136	(ABC) transporter
K5K99_RS09640	COG0577	efflux transmembrane transporter activity
K5K99_RS09645	COG0751	glycine-tRNA ligase activity
K5K99_RS09650	COG0752	glycyl-tRNA synthetase alpha subunit
K5K99_RS09655	COG1381	Involved in DNA repair and RecF pathway recombination
K5K99_RS09660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5K99_RS09665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K5K99_RS09670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K5K99_RS09680	COG1702	phosphate starvation-inducible protein PhoH
K5K99_RS09690	COG0735	belongs to the Fur family
K5K99_RS09695	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5K99_RS09705	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K5K99_RS09710	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K5K99_RS09715	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K5K99_RS09720	COG4974	Belongs to the 'phage' integrase family
K5K99_RS09725	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K5K99_RS09730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5K99_RS09735	COG0758	DNA mediated transformation
K5K99_RS09740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5K99_RS09745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5K99_RS09755	COG3409	Peptidoglycan-binding domain 1 protein
K5K99_RS09755	COG0793	Belongs to the peptidase S41A family
K5K99_RS09760	COG4479	Belongs to the UPF0346 family
K5K99_RS09775	COG2755	lipolytic protein G-D-S-L family
K5K99_RS09780	COG1307	EDD domain protein, DegV family
K5K99_RS09785	COG1272	protein, Hemolysin III
K5K99_RS09800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K5K99_RS09805	COG0488	(ABC) transporter
K5K99_RS09820	COG0617	tRNA 3'-terminal CCA addition
K5K99_RS09825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K5K99_RS09830	COG1694	Mazg nucleotide pyrophosphohydrolase
K5K99_RS09835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K99_RS09845	COG3426	butyrate kinase activity
K5K99_RS09850	COG0280	phosphate acetyltransferase
K5K99_RS09880	COG0583	DNA-binding transcription factor activity
K5K99_RS09890	COG5582	Belongs to the UPF0302 family
K5K99_RS09915	COG1160	GTP binding
K5K99_RS09920	COG0539	negative regulation of cytoplasmic translation
K5K99_RS09925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5K99_RS09930	COG1134	teichoic acid transport
K5K99_RS09930	COG1388	LysM domain
K5K99_RS09935	COG0514	ATP-dependent DNA helicase (RecQ)
K5K99_RS09950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5K99_RS09950	COG2755	lipolytic protein G-D-S-L family
K5K99_RS09955	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K5K99_RS09960	COG1187	pseudouridine synthase activity
K5K99_RS09965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K5K99_RS09970	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K5K99_RS09975	COG4974	Belongs to the 'phage' integrase family
K5K99_RS09990	COG0735	belongs to the Fur family
K5K99_RS09995	COG2996	Protein conserved in bacteria
K5K99_RS10010	COG2814	Major facilitator Superfamily
K5K99_RS10020	COG0205	6-phosphofructokinase activity
K5K99_RS10025	COG0587	DNA-directed DNA polymerase activity
K5K99_RS10040	COG2814	Major facilitator Superfamily
K5K99_RS10050	COG2252	PERMEase
K5K99_RS10055	COG1725	Transcriptional regulator
K5K99_RS10060	COG1131	(ABC) transporter
K5K99_RS10080	COG0653	protein targeting
K5K99_RS10125	COG3541	Predicted nucleotidyltransferase
K5K99_RS10210	COG4974	Belongs to the 'phage' integrase family
K5K99_RS10220	COG0577	efflux transmembrane transporter activity
K5K99_RS10225	COG1136	(ABC) transporter
K5K99_RS10230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K5K99_RS10240	COG2153	protein acetylation
K5K99_RS10245	COG2910	NAD(P)H-binding
K5K99_RS10250	COG1959	2 iron, 2 sulfur cluster binding
K5K99_RS10255	COG0513	Belongs to the DEAD box helicase family
K5K99_RS10265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5K99_RS10275	COG1307	EDD domain protein, DegV family
K5K99_RS10285	COG0077	Prephenate dehydratase
K5K99_RS10290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K5K99_RS10300	COG0287	Prephenate dehydrogenase
K5K99_RS10305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5K99_RS10315	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K5K99_RS10320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5K99_RS10330	COG0406	alpha-ribazole phosphatase activity
K5K99_RS10360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5K99_RS10365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K5K99_RS10370	COG0509	glycine decarboxylation via glycine cleavage system
K5K99_RS10375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5K99_RS10380	COG0477	Major facilitator Superfamily
K5K99_RS10385	COG4166	transmembrane transport
K5K99_RS10390	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K5K99_RS10395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K5K99_RS10410	COG5002	protein histidine kinase activity
K5K99_RS10415	COG0745	RESPONSE REGULATOR receiver
K5K99_RS10420	COG0114	fumarate hydratase activity
K5K99_RS10425	COG0281	malic enzyme
K5K99_RS10430	COG1027	Aspartate ammonia-lyase
K5K99_RS10440	COG4753	response regulator
K5K99_RS10440	COG2207	Transcriptional regulator
K5K99_RS10460	COG0772	Belongs to the SEDS family
K5K99_RS10470	COG1609	Transcriptional regulator
K5K99_RS10480	COG0745	RESPONSE REGULATOR receiver
K5K99_RS10490	COG1136	(ABC) transporter
K5K99_RS10495	COG0577	efflux transmembrane transporter activity
K5K99_RS10500	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5K99_RS10505	COG1263	PTS System
K5K99_RS10505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS10505	COG2190	(PTS) system
K5K99_RS10510	COG3711	transcriptional antiterminator
K5K99_RS10520	COG0436	Aminotransferase
K5K99_RS10525	COG1522	sequence-specific DNA binding
K5K99_RS10530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5K99_RS10550	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K5K99_RS10560	COG3711	transcriptional antiterminator
K5K99_RS10565	COG2723	6-phospho-beta-galactosidase activity
K5K99_RS10570	COG2190	(PTS) system
K5K99_RS10570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS10570	COG1263	PTS System
K5K99_RS10575	COG1764	response to oxidative stress
K5K99_RS10580	COG0335	large ribosomal subunit rRNA binding
K5K99_RS10585	COG0336	Belongs to the RNA methyltransferase TrmD family
K5K99_RS10590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5K99_RS10600	COG1837	Belongs to the UPF0109 family
K5K99_RS10610	COG1131	(ABC) transporter
K5K99_RS10625	COG0745	RESPONSE REGULATOR receiver
K5K99_RS10630	COG2205	protein histidine kinase activity
K5K99_RS10635	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K5K99_RS10640	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K5K99_RS10645	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K5K99_RS10670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5K99_RS10675	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K5K99_RS10680	COG5002	protein histidine kinase activity
K5K99_RS10685	COG0745	RESPONSE REGULATOR receiver
K5K99_RS10690	COG1132	(ABC) transporter
K5K99_RS10695	COG1132	(ABC) transporter
K5K99_RS10700	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5K99_RS10710	COG0803	Belongs to the bacterial solute-binding protein 9 family
K5K99_RS10715	COG0484	heat shock protein binding
K5K99_RS10720	COG0443	Heat shock 70 kDa protein
K5K99_RS10725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5K99_RS10730	COG1420	regulation of RNA biosynthetic process
K5K99_RS10735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5K99_RS10740	COG0196	riboflavin kinase activity
K5K99_RS10745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K5K99_RS10750	COG1363	Peptidase, m42
K5K99_RS10755	COG0673	inositol 2-dehydrogenase activity
K5K99_RS10760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K5K99_RS10775	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K5K99_RS10780	COG0195	Participates in both transcription termination and antitermination
K5K99_RS10785	COG0779	Required for maturation of 30S ribosomal subunits
K5K99_RS10790	COG1408	metallophosphoesterase
K5K99_RS10800	COG0442	prolyl-tRNA aminoacylation
K5K99_RS10805	COG0750	zinc metalloprotease
K5K99_RS10810	COG4589	Belongs to the CDS family
K5K99_RS10815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5K99_RS10820	COG0233	cytoplasmic translational termination
K5K99_RS10825	COG0528	UMP kinase activity
K5K99_RS10830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5K99_RS10835	COG0052	Belongs to the universal ribosomal protein uS2 family
K5K99_RS10840	COG0588	phosphoglycerate mutase activity
K5K99_RS10855	COG0789	Transcriptional regulator
K5K99_RS10865	COG1968	undecaprenyl-diphosphatase activity
K5K99_RS10870	COG2217	Heavy metal translocating P-type atpase
K5K99_RS10875	COG1307	EDD domain protein, DegV family
K5K99_RS10885	COG1307	EDD domain protein, DegV family
K5K99_RS10895	COG1466	dna polymerase III delta subunit
K5K99_RS10900	COG0658	competence protein
K5K99_RS10900	COG2333	competence protein COMEC
K5K99_RS10905	COG2131	deaminase
K5K99_RS10910	COG1555	photosystem II stabilization
K5K99_RS10915	COG3480	Lon protease (S16) C-terminal proteolytic domain
K5K99_RS10920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K5K99_RS10925	COG0742	ribosomal rna small subunit methyltransferase
K5K99_RS10930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5K99_RS10945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5K99_RS10955	COG0789	Transcriptional regulator
K5K99_RS10960	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K5K99_RS10965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5K99_RS10970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5K99_RS10975	COG0584	glycerophosphoryl diester phosphodiesterase
K5K99_RS10985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5K99_RS10990	COG1940	carbohydrate kinase activity
K5K99_RS11000	COG0457	Tetratricopeptide repeat
K5K99_RS11000	COG0705	Rhomboid family
K5K99_RS11005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5K99_RS11030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K5K99_RS11035	COG0768	penicillin binding
K5K99_RS11040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5K99_RS11050	COG1131	(ABC) transporter
K5K99_RS11055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5K99_RS11065	COG0577	efflux transmembrane transporter activity
K5K99_RS11070	COG1136	(ABC) transporter
K5K99_RS11075	COG0025	NhaP-type Na H and K H
K5K99_RS11080	COG1674	ftsk spoiiie
K5K99_RS11080	COG1280	lysine exporter protein (LysE YggA)
K5K99_RS11085	COG1012	belongs to the aldehyde dehydrogenase family
K5K99_RS11090	COG0551	DNA topoisomerase type I activity
K5K99_RS11090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5K99_RS11100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K99_RS11110	COG0482	sulfurtransferase activity
K5K99_RS11115	COG2814	Major facilitator Superfamily
K5K99_RS11130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5K99_RS11150	COG2184	nucleotidyltransferase activity
K5K99_RS11165	COG1104	cysteine desulfurase activity
K5K99_RS11170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5K99_RS11175	COG0656	L-ascorbic acid biosynthetic process
K5K99_RS11195	COG1129	ABC transporter
K5K99_RS11210	COG0737	Belongs to the 5'-nucleotidase family
K5K99_RS11220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K5K99_RS11240	COG0583	DNA-binding transcription factor activity
K5K99_RS11250	COG1979	alcohol dehydrogenase
K5K99_RS11260	COG0514	ATP-dependent DNA helicase (RecQ)
K5K99_RS11265	COG2860	membrane
K5K99_RS11280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5K99_RS11290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5K99_RS11295	COG0583	DNA-binding transcription factor activity
K5K99_RS11305	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5K99_RS11310	COG0022	dehydrogenase e1 component
K5K99_RS11315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K99_RS11320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K99_RS11325	COG3426	butyrate kinase activity
K5K99_RS11330	COG0280	phosphate acetyltransferase
K5K99_RS11335	COG0386	Belongs to the glutathione peroxidase family
K5K99_RS11340	COG4807	Protein conserved in bacteria
K5K99_RS11345	COG1671	Belongs to the UPF0178 family
K5K99_RS11350	COG2223	nitrite transmembrane transporter activity
K5K99_RS11370	COG1473	amidohydrolase
K5K99_RS11380	COG0673	inositol 2-dehydrogenase activity
K5K99_RS11385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_RS11385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5K99_RS11410	COG0673	inositol 2-dehydrogenase activity
K5K99_RS11425	COG0395	ABC-type sugar transport system, permease component
K5K99_RS11430	COG1175	transmembrane transport
K5K99_RS11435	COG2182	Extracellular solute-binding protein
K5K99_RS11440	COG0673	inositol 2-dehydrogenase activity
K5K99_RS11480	COG3493	citrate carrier protein
K5K99_RS11485	COG3290	protein histidine kinase activity
K5K99_RS11490	COG4565	transcriptional regulatory protein
K5K99_RS11505	COG3328	transposase activity
K5K99_RS11590	COG3328	transposase activity
K5K99_RS11605	COG1609	Transcriptional regulator
K5K99_RS11605	COG2207	Transcriptional regulator
K5K99_RS11610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5K99_RS11655	COG0582	viral genome integration into host DNA
K5K99_RS11665	COG0719	Fe-S assembly protein
K5K99_RS11670	COG0822	iron-sulfur transferase activity
K5K99_RS11675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5K99_RS11680	COG0719	Fe-S assembly protein
K5K99_RS11690	COG1464	Belongs to the NlpA lipoprotein family
K5K99_RS11695	COG2011	ABC-type metal ion transport system permease component
K5K99_RS11700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5K99_RS11710	COG1937	Protein conserved in bacteria
K5K99_RS11715	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K99_RS11720	COG0488	(ABC) transporter
K5K99_RS11735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5K99_RS11740	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K5K99_RS11750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5K99_RS11755	COG0517	IMP dehydrogenase activity
K5K99_RS11760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5K99_RS11760	COG0574	Belongs to the PEP-utilizing enzyme family
K5K99_RS11770	COG1131	(ABC) transporter
K5K99_RS11790	COG0488	(ABC) transporter
K5K99_RS11795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5K99_RS11810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K5K99_RS11825	COG1476	TRANSCRIPTIONal
K5K99_RS11830	COG1368	sulfuric ester hydrolase activity
K5K99_RS11835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K5K99_RS11840	COG1660	Displays ATPase and GTPase activities
K5K99_RS11845	COG0254	rRNA binding
K5K99_RS11850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K5K99_RS11855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5K99_RS11865	COG1012	belongs to the aldehyde dehydrogenase family
K5K99_RS11880	COG3343	RNA polymerase activity
K5K99_RS11895	COG1078	dGTPase activity
K5K99_RS11900	COG0561	phosphatase activity
K5K99_RS11910	COG0516	GMP reductase activity
K5K99_RS11920	COG1131	(ABC) transporter
K5K99_RS11925	COG4989	oxidoreductase activity
K5K99_RS11935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5K99_RS11940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5K99_RS11945	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K99_RS11945	COG3942	CHAP domain
K5K99_RS11970	COG4467	Involved in initiation control of chromosome replication
K5K99_RS11975	COG1774	PSP1 C-terminal conserved region
K5K99_RS11980	COG0470	DNA polymerase III
K5K99_RS11985	COG3870	Protein conserved in bacteria
K5K99_RS11990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5K99_RS11995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5K99_RS12000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5K99_RS12005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5K99_RS12010	COG1073	alpha beta
K5K99_RS12020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K5K99_RS12025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K5K99_RS12030	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K5K99_RS12035	COG1950	PFAM Membrane protein of
K5K99_RS12050	COG1196	nuclear chromosome segregation
K5K99_RS12050	COG0741	lytic transglycosylase activity
K5K99_RS12050	COG0739	heme binding
K5K99_RS12055	COG0704	Plays a role in the regulation of phosphate uptake
K5K99_RS12060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5K99_RS12065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5K99_RS12070	COG0581	inorganic phosphate transmembrane transporter activity
K5K99_RS12075	COG0573	inorganic phosphate transmembrane transporter activity
K5K99_RS12090	COG2177	Part of the ABC transporter FtsEX involved in
K5K99_RS12095	COG2884	Cell division ATP-binding protein ftsE
K5K99_RS12105	COG0653	protein targeting
K5K99_RS12115	COG1040	competence protein
K5K99_RS12120	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K5K99_RS12125	COG2267	carboxylic ester hydrolase activity
K5K99_RS12135	COG1739	Uncharacterized protein family UPF0029
K5K99_RS12140	COG2188	Transcriptional regulator
K5K99_RS12150	COG1309	transcriptional regulator
K5K99_RS12185	COG0517	IMP dehydrogenase activity
K5K99_RS12195	COG0411	ABC transporter
K5K99_RS12205	COG0559	Belongs to the binding-protein-dependent transport system permease family
K5K99_RS12215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5K99_RS12225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K5K99_RS12240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5K99_RS12245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5K99_RS12250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5K99_RS12255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5K99_RS12260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K99_RS12265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5K99_RS12270	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5K99_RS12275	COG0356	it plays a direct role in the translocation of protons across the membrane
K5K99_RS12280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K5K99_RS12285	COG0557	exoribonuclease II activity
K5K99_RS12300	COG3397	chitin binding
K5K99_RS12305	COG1942	4-Oxalocrotonate Tautomerase
K5K99_RS12345	COG2378	regulation of single-species biofilm formation
K5K99_RS12360	COG0716	FMN binding
K5K99_RS12380	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K5K99_RS12400	COG0590	tRNA wobble adenosine to inosine editing
K5K99_RS12405	COG1953	Uracil, thiamine, allantoin
K5K99_RS12410	COG0666	response to abiotic stimulus
K5K99_RS12415	COG1304	FMN binding
K5K99_RS12420	COG1304	FMN binding
K5K99_RS12425	COG2508	Transcriptional regulator
K5K99_RS12435	COG1132	(ABC) transporter
K5K99_RS12440	COG4988	ABC transporter
K5K99_RS12450	COG1288	antiporter activity
K5K99_RS12455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K99_RS12465	COG1609	Transcriptional regulator
K5K99_RS12475	COG0024	Methionine aminopeptidase
K5K99_RS12485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K5K99_RS12490	COG0149	triose-phosphate isomerase activity
K5K99_RS12495	COG0126	phosphoglycerate kinase activity
K5K99_RS12505	COG2390	Transcriptional regulator
K5K99_RS12510	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K5K99_RS12520	COG0740	serine-type endopeptidase activity
K5K99_RS12545	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5K99_RS12550	COG0022	dehydrogenase e1 component
K5K99_RS12555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5K99_RS12560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5K99_RS12565	COG3284	Transcriptional regulator
K5K99_RS12570	COG1481	regulation of sporulation
K5K99_RS12580	COG1660	Displays ATPase and GTPase activities
K5K99_RS12585	COG2186	Transcriptional regulator
K5K99_RS12590	COG1131	(ABC) transporter
K5K99_RS12605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5K99_RS12610	COG0556	nucleotide-excision repair
K5K99_RS12615	COG3579	cysteine-type endopeptidase activity
K5K99_RS12620	COG1316	TRANSCRIPTIONal
K5K99_RS12625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K5K99_RS12635	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K5K99_RS12640	COG2304	oxidoreductase activity
K5K99_RS12650	COG0714	Associated with various cellular activities
K5K99_RS12655	COG4716	Myosin-crossreactive antigen
K5K99_RS12670	COG2608	mercury ion transmembrane transporter activity
K5K99_RS12675	COG2723	6-phospho-beta-galactosidase activity
K5K99_RS12680	COG1263	PTS System
K5K99_RS12680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS12680	COG2190	(PTS) system
K5K99_RS12685	COG3711	transcriptional antiterminator
K5K99_RS12695	COG0436	Aminotransferase
K5K99_RS12705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5K99_RS12705	COG1199	ATP-dependent helicase activity
K5K99_RS12715	COG2246	polysaccharide biosynthetic process
K5K99_RS12765	COG1098	S1 RNA binding domain
K5K99_RS12770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5K99_RS12775	COG0572	uridine kinase
K5K99_RS12780	COG4619	ABC transporter
K5K99_RS12785	COG0390	transport system, permease component
K5K99_RS12795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5K99_RS12800	COG2188	Transcriptional regulator
K5K99_RS12805	COG1446	asparaginase
K5K99_RS12825	COG4608	Belongs to the ABC transporter superfamily
K5K99_RS12830	COG0444	Belongs to the ABC transporter superfamily
K5K99_RS12835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5K99_RS12840	COG0601	transmembrane transport
K5K99_RS12850	COG4166	transmembrane transport
K5K99_RS12860	COG3716	PTS system mannose fructose sorbose family IID component
K5K99_RS12865	COG3715	PTS system
K5K99_RS12875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS12875	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5K99_RS12880	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5K99_RS12880	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5K99_RS12895	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5K99_RS12900	COG4166	transmembrane transport
K5K99_RS12905	COG4166	transmembrane transport
K5K99_RS12910	COG4166	transmembrane transport
K5K99_RS12920	COG4948	Mandelate Racemase Muconate Lactonizing
K5K99_RS12935	COG2723	6-phospho-beta-galactosidase activity
K5K99_RS12940	COG0371	Dehydrogenase
K5K99_RS12945	COG0765	amino acid transport
K5K99_RS12950	COG1126	abc transporter atp-binding protein
K5K99_RS12955	COG0436	Aminotransferase
K5K99_RS12965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K5K99_RS12970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5K99_RS12985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5K99_RS12990	COG0741	lytic transglycosylase activity
K5K99_RS12990	COG1196	nuclear chromosome segregation
K5K99_RS12990	COG0739	heme binding
K5K99_RS12995	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K99_RS12995	COG3942	CHAP domain
K5K99_RS13010	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5K99_RS13015	COG2514	catechol 2,3-dioxygenase activity
K5K99_RS13030	COG2217	Heavy metal translocating P-type atpase
K5K99_RS13040	COG5002	protein histidine kinase activity
K5K99_RS13045	COG0745	RESPONSE REGULATOR receiver
K5K99_RS13050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5K99_RS13055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5K99_RS13060	COG0544	peptidyl-prolyl cis-trans isomerase activity
K5K99_RS13070	COG4703	Protein of unknown function (DUF1797)
K5K99_RS13075	COG2084	Dehydrogenase
K5K99_RS13085	COG0438	transferase activity, transferring glycosyl groups
K5K99_RS13090	COG0438	transferase activity, transferring glycosyl groups
K5K99_RS13095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5K99_RS13110	COG0542	response to heat
K5K99_RS13120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K99_RS13120	COG0463	Glycosyl transferase, family 2
K5K99_RS13130	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K5K99_RS13150	COG1216	Glycosyl transferase, family 2
K5K99_RS13160	COG0463	Glycosyl transferase, family 2
K5K99_RS13175	COG1253	flavin adenine dinucleotide binding
K5K99_RS13180	COG0628	permease
K5K99_RS13185	COG2153	protein acetylation
K5K99_RS13200	COG3328	transposase activity
K5K99_RS13205	COG1215	transferase activity, transferring glycosyl groups
K5K99_RS13205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K99_RS13210	COG3557	Belongs to the UPF0374 family
K5K99_RS13215	COG1194	a g-specific adenine glycosylase
K5K99_RS13220	COG2137	regulation of response to DNA damage stimulus
K5K99_RS13225	COG0583	DNA-binding transcription factor activity
K5K99_RS13255	COG3328	transposase activity
K5K99_RS13260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5K99_RS13295	COG3328	transposase activity
K5K99_RS13320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5K99_RS13350	COG0589	response to stress
K5K99_RS13360	COG1316	TRANSCRIPTIONal
K5K99_RS13365	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5K99_RS13375	COG1216	Glycosyl transferase, family 2
K5K99_RS13400	COG1086	Polysaccharide biosynthesis protein
K5K99_RS13405	COG0297	glycogen (starch) synthase activity
K5K99_RS13425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5K99_RS13430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5K99_RS13440	COG4464	protein tyrosine phosphatase activity
K5K99_RS13445	COG0489	protein tyrosine kinase activity
K5K99_RS13455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K99_RS13460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K99_RS13465	COG1682	transport, permease protein
K5K99_RS13470	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K5K99_RS13475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K5K99_RS13480	COG1134	teichoic acid transport
K5K99_RS13485	COG1316	TRANSCRIPTIONal
K5K99_RS13490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5K99_RS13500	COG1295	ribonuclease BN
K5K99_RS13505	COG0024	Methionine aminopeptidase
K5K99_RS13510	COG0716	FMN binding
K5K99_RS13520	COG2309	aminopeptidase activity
K5K99_RS13525	COG0726	polysaccharide deacetylase
K5K99_RS13535	COG3850	Histidine kinase
K5K99_RS13535	COG5002	protein histidine kinase activity
K5K99_RS13540	COG0745	RESPONSE REGULATOR receiver
K5K99_RS13550	COG1316	TRANSCRIPTIONal
K5K99_RS13565	COG1447	Phosphotransferase system cellobiose-specific component IIA
K5K99_RS13570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_RS13590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5K99_RS13600	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5K99_RS13600	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K5K99_RS13605	COG0513	Belongs to the DEAD box helicase family
K5K99_RS13625	COG1846	Transcriptional regulator
K5K99_RS13630	COG1132	(ABC) transporter
K5K99_RS13645	COG2388	GCN5-related N-acetyl-transferase
K5K99_RS13650	COG5503	Protein of unknown function (DUF1447)
K5K99_RS13660	COG1278	Cold shock
K5K99_RS13665	COG2003	Belongs to the UPF0758 family
K5K99_RS13670	COG0546	phosphoglycolate phosphatase activity
K5K99_RS13675	COG0285	dihydrofolate synthase activity
K5K99_RS13680	COG0525	valine-tRNA ligase activity
K5K99_RS13690	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K5K99_RS13695	COG0301	tRNA thio-modification
K5K99_RS13700	COG1104	cysteine desulfurase activity
K5K99_RS13705	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K5K99_RS13710	COG0527	aspartate kinase activity
K5K99_RS13725	COG0561	phosphatase activity
K5K99_RS13745	COG3594	Acyltransferase
K5K99_RS13765	COG3091	SprT-like family
K5K99_RS13770	COG2183	response to ionizing radiation
K5K99_RS13780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K5K99_RS13795	COG0681	Belongs to the peptidase S26 family
K5K99_RS13805	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5K99_RS13810	COG1876	peptidase activity
K5K99_RS13820	COG4129	membrane
K5K99_RS13835	COG0384	phenazine biosynthesis protein PhzF
K5K99_RS13845	COG0789	Transcriptional regulator
K5K99_RS13860	COG2268	Band 7 protein
K5K99_RS13920	COG0436	Aminotransferase
K5K99_RS13930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K5K99_RS13945	COG1174	glycine betaine transport
K5K99_RS13955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K5K99_RS13960	COG3599	regulation of cell shape
K5K99_RS13965	COG2302	S4 RNA-binding domain
K5K99_RS13975	COG1799	cell septum assembly
K5K99_RS13980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5K99_RS13985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5K99_RS13990	COG0849	cell division
K5K99_RS13995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5K99_RS14000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K5K99_RS14005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5K99_RS14010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5K99_RS14015	COG0768	penicillin binding
K5K99_RS14025	COG0275	rRNA processing
K5K99_RS14030	COG2001	Belongs to the MraZ family
K5K99_RS14045	COG0497	DNA recombination
K5K99_RS14050	COG1438	arginine binding
K5K99_RS14055	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K5K99_RS14065	COG1722	exodeoxyribonuclease VII activity
K5K99_RS14070	COG1570	exodeoxyribonuclease VII activity
K5K99_RS14075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K5K99_RS14080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5K99_RS14085	COG1302	Protein conserved in bacteria
K5K99_RS14090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K5K99_RS14095	COG0006	proline dipeptidase activity
K5K99_RS14175	COG0582	viral genome integration into host DNA
K5K99_RS14180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K5K99_RS14185	COG2868	ribosomal protein
K5K99_RS14190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5K99_RS14205	COG4122	O-methyltransferase activity
K5K99_RS14210	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K5K99_RS14215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K5K99_RS14220	COG0222	ribosome binding
K5K99_RS14225	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5K99_RS14230	COG0081	regulation of translation
K5K99_RS14235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5K99_RS14245	COG2217	Heavy metal translocating P-type atpase
K5K99_RS14250	COG0673	inositol 2-dehydrogenase activity
K5K99_RS14270	COG0673	inositol 2-dehydrogenase activity
K5K99_RS14280	COG1418	mRNA catabolic process
K5K99_RS14285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5K99_RS14290	COG1546	Belongs to the CinA family
K5K99_RS14290	COG1058	Belongs to the CinA family
K5K99_RS14295	COG1760	l-serine dehydratase
K5K99_RS14300	COG1760	l-serine dehydratase
K5K99_RS14315	COG1757	Na H antiporter
K5K99_RS14325	COG0250	Participates in transcription elongation, termination and antitermination
K5K99_RS14365	COG1609	Transcriptional regulator
K5K99_RS14370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5K99_RS14375	COG0698	ribose 5-phosphate isomerase
K5K99_RS14380	COG1263	PTS System
K5K99_RS14380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5K99_RS14380	COG2190	(PTS) system
K5K99_RS14415	COG1192	Involved in chromosome partitioning
K5K99_RS14545	COG0741	lytic transglycosylase activity
K5K99_RS14545	COG0791	NLP P60 protein
K5K99_RS14635	COG0768	penicillin binding
K5K99_RS14780	COG1953	Uracil, thiamine, allantoin