locus-tag	class	description
M2905_RS00005	COG0736	holo-[acyl-carrier-protein] synthase activity
M2905_RS00020	COG4443	Transcriptional Coactivator p15 (PC4)
M2905_RS00025	COG1561	YicC-like family, N-terminal region
M2905_RS00030	COG0194	GDP metabolic process
M2905_RS00040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M2905_RS00045	COG0242	peptide deformylase activity
M2905_RS00050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M2905_RS00055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M2905_RS00055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2905_RS00060	COG0631	protein serine/threonine phosphatase activity
M2905_RS00065	COG2815	serine threonine protein kinase
M2905_RS00065	COG0515	serine threonine protein kinase
M2905_RS00070	COG0785	Cytochrome C biogenesis protein
M2905_RS00080	COG1162	GTPase activity
M2905_RS00085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M2905_RS00090	COG1564	THIamine pyrophosphokinase
M2905_RS00095	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M2905_RS00110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M2905_RS00115	COG0416	fatty acid biosynthetic process
M2905_RS00120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2905_RS00130	COG4608	Belongs to the ABC transporter superfamily
M2905_RS00135	COG0601	transmembrane transport
M2905_RS00155	COG0571	ribonuclease III activity
M2905_RS00160	COG1196	nuclear chromosome segregation
M2905_RS00165	COG0561	phosphatase activity
M2905_RS00170	COG0552	protein localization to endoplasmic reticulum
M2905_RS00175	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2905_RS00175	COG2918	glutathione biosynthetic process
M2905_RS00180	COG3853	Toxic anion resistance protein (TelA)
M2905_RS00200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M2905_RS00205	COG1335	isochorismatase
M2905_RS00210	COG3594	Acyltransferase
M2905_RS00215	COG1104	cysteine desulfurase activity
M2905_RS00225	COG0482	sulfurtransferase activity
M2905_RS00230	COG2207	Transcriptional regulator
M2905_RS00230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M2905_RS00235	COG1132	(ABC) transporter
M2905_RS00240	COG1132	(ABC) transporter
M2905_RS00255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M2905_RS00265	COG0719	Fe-S assembly protein
M2905_RS00270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M2905_RS00275	COG0822	iron-sulfur transferase activity
M2905_RS00285	COG3711	transcriptional antiterminator
M2905_RS00290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS00290	COG1263	PTS System
M2905_RS00290	COG2190	(PTS) system
M2905_RS00305	COG1846	Transcriptional regulator
M2905_RS00305	COG1940	carbohydrate kinase activity
M2905_RS00315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2905_RS00335	COG2207	Transcriptional regulator
M2905_RS00335	COG4753	response regulator
M2905_RS00340	COG2972	Histidine kinase
M2905_RS00345	COG1053	succinate dehydrogenase
M2905_RS00345	COG3976	FMN-binding domain protein
M2905_RS00350	COG0346	lactoylglutathione lyase activity
M2905_RS00370	COG0450	alkyl hydroperoxide reductase
M2905_RS00375	COG3104	oligopeptide transport
M2905_RS00390	COG0431	NADPH-dependent FMN reductase
M2905_RS00390	COG3976	FMN-binding domain protein
M2905_RS00390	COG1053	succinate dehydrogenase
M2905_RS00410	COG0406	alpha-ribazole phosphatase activity
M2905_RS00420	COG2190	(PTS) system
M2905_RS00420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS00420	COG1263	PTS System
M2905_RS00425	COG2723	6-phospho-beta-galactosidase activity
M2905_RS00450	COG0395	ABC-type sugar transport system, permease component
M2905_RS00460	COG4209	transmembrane transport
M2905_RS00465	COG2197	response regulator
M2905_RS00470	COG2972	Histidine kinase
M2905_RS00500	COG1940	carbohydrate kinase activity
M2905_RS00510	COG1473	amidohydrolase
M2905_RS00545	COG0420	3'-5' exonuclease activity
M2905_RS00550	COG0419	ATPase involved in DNA repair
M2905_RS00560	COG1846	Transcriptional regulator
M2905_RS00565	COG0346	lactoylglutathione lyase activity
M2905_RS00575	COG0431	NADPH-dependent FMN reductase
M2905_RS00585	COG0415	Belongs to the DNA photolyase family
M2905_RS00600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M2905_RS00610	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M2905_RS00615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M2905_RS00620	COG1534	Rna-binding protein
M2905_RS00625	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M2905_RS00630	COG1713	HD superfamily hydrolase involved in NAD metabolism
M2905_RS00635	COG0799	negative regulation of ribosome biogenesis
M2905_RS00640	COG2226	methyltransferase
M2905_RS00650	COG0516	GMP reductase activity
M2905_RS00660	COG0351	phosphomethylpyrimidine kinase
M2905_RS00665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2905_RS00690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M2905_RS00695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2905_RS00705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M2905_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
M2905_RS00715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M2905_RS00725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M2905_RS00730	COG0439	Biotin carboxylase
M2905_RS00735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M2905_RS00740	COG0825	malonyl-CoA metabolic process
M2905_RS00745	COG0583	DNA-binding transcription factor activity
M2905_RS00770	COG0280	phosphate acetyltransferase
M2905_RS00780	COG1126	abc transporter atp-binding protein
M2905_RS00785	COG0765	amino acid transport
M2905_RS00790	COG2966	Psort location CytoplasmicMembrane, score
M2905_RS00810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2905_RS00815	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M2905_RS00825	COG0514	ATP-dependent DNA helicase (RecQ)
M2905_RS00830	COG2217	Heavy metal translocating P-type atpase
M2905_RS00835	COG1073	alpha beta
M2905_RS00840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2905_RS00845	COG2011	ABC-type metal ion transport system permease component
M2905_RS00850	COG1464	Belongs to the NlpA lipoprotein family
M2905_RS00855	COG1473	amidohydrolase
M2905_RS00865	COG0513	Belongs to the DEAD box helicase family
M2905_RS00870	COG3275	phosphorelay sensor kinase activity
M2905_RS00875	COG3279	Response regulator of the LytR AlgR family
M2905_RS00880	COG1966	Carbon starvation protein
M2905_RS00890	COG1269	ATP hydrolysis coupled proton transport
M2905_RS00895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2905_RS00905	COG1527	subunit (C
M2905_RS00910	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
M2905_RS00915	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
M2905_RS00920	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
M2905_RS00945	COG0363	glucosamine-6-phosphate deaminase activity
M2905_RS00950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M2905_RS00955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M2905_RS00960	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M2905_RS00965	COG1609	Transcriptional regulator
M2905_RS00970	COG1214	PFAM Peptidase M22, glycoprotease
M2905_RS00980	COG0456	acetyltransferase
M2905_RS00985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M2905_RS00995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M2905_RS01020	COG0588	phosphoglycerate mutase activity
M2905_RS01025	COG0745	RESPONSE REGULATOR receiver
M2905_RS01030	COG2205	protein histidine kinase activity
M2905_RS01035	COG0765	amino acid transport
M2905_RS01040	COG1126	abc transporter atp-binding protein
M2905_RS01045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2905_RS01050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M2905_RS01055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M2905_RS01065	COG4585	Histidine kinase
M2905_RS01070	COG2197	response regulator
M2905_RS01075	COG0569	domain protein
M2905_RS01100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M2905_RS01110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2905_RS01120	COG1129	ABC transporter
M2905_RS01135	COG1428	Deoxynucleoside kinase
M2905_RS01140	COG1486	melibiose metabolic process
M2905_RS01150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M2905_RS01155	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M2905_RS01155	COG0392	lysyltransferase activity
M2905_RS01170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2905_RS01180	COG3158	transport of potassium into the cell
M2905_RS01190	COG2814	Major facilitator Superfamily
M2905_RS01195	COG1252	NADH dehydrogenase
M2905_RS01205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2905_RS01210	COG3442	glutamine amidotransferase
M2905_RS01215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2905_RS01230	COG2746	aminoglycoside 3-N-acetyltransferase activity
M2905_RS01245	COG1757	Na H antiporter
M2905_RS01250	COG1609	Transcriptional regulator
M2905_RS01260	COG0556	nucleotide-excision repair
M2905_RS01265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M2905_RS01270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M2905_RS01275	COG1660	Displays ATPase and GTPase activities
M2905_RS01280	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M2905_RS01285	COG1481	regulation of sporulation
M2905_RS01290	COG0740	serine-type endopeptidase activity
M2905_RS01300	COG0335	large ribosomal subunit rRNA binding
M2905_RS01305	COG2514	catechol 2,3-dioxygenase activity
M2905_RS01310	COG1268	BioY protein
M2905_RS01315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2905_RS01320	COG1073	alpha beta
M2905_RS01325	COG2151	metal-sulfur cluster biosynthetic enzyme
M2905_RS01360	COG0280	phosphate acetyltransferase
M2905_RS01365	COG3426	butyrate kinase activity
M2905_RS01370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2905_RS01375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M2905_RS01380	COG0022	dehydrogenase e1 component
M2905_RS01385	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2905_RS01395	COG0583	DNA-binding transcription factor activity
M2905_RS01410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M2905_RS01415	COG1882	Formate acetyltransferase
M2905_RS01420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M2905_RS01425	COG1227	inorganic diphosphatase activity
M2905_RS01430	COG1187	pseudouridine synthase activity
M2905_RS01445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M2905_RS01445	COG1199	ATP-dependent helicase activity
M2905_RS01455	COG0436	Aminotransferase
M2905_RS01470	COG2608	mercury ion transmembrane transporter activity
M2905_RS01475	COG2217	Heavy metal translocating P-type atpase
M2905_RS01485	COG2252	PERMEase
M2905_RS01490	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M2905_RS01500	COG2996	Protein conserved in bacteria
M2905_RS01510	COG0735	belongs to the Fur family
M2905_RS01515	COG4974	Belongs to the 'phage' integrase family
M2905_RS01520	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M2905_RS01525	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M2905_RS01530	COG1187	pseudouridine synthase activity
M2905_RS01535	COG0745	RESPONSE REGULATOR receiver
M2905_RS01540	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M2905_RS01555	COG0514	ATP-dependent DNA helicase (RecQ)
M2905_RS01565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M2905_RS01570	COG0539	negative regulation of cytoplasmic translation
M2905_RS01575	COG1160	GTP binding
M2905_RS01590	COG5582	Belongs to the UPF0302 family
M2905_RS01605	COG0126	phosphoglycerate kinase activity
M2905_RS01610	COG0149	triose-phosphate isomerase activity
M2905_RS01650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2905_RS01715	COG0456	acetyltransferase
M2905_RS01810	COG3448	diguanylate cyclase activity
M2905_RS01810	COG4175	Glycine betaine
M2905_RS01820	COG0039	L-malate dehydrogenase activity
M2905_RS01835	COG1304	FMN binding
M2905_RS01850	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M2905_RS01870	COG3425	synthase
M2905_RS01875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M2905_RS01885	COG3290	protein histidine kinase activity
M2905_RS01885	COG3829	transcription factor binding
M2905_RS01890	COG1454	alcohol dehydrogenase
M2905_RS01895	COG1012	belongs to the aldehyde dehydrogenase family
M2905_RS01910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M2905_RS01920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M2905_RS01925	COG1234	tRNA 3'-trailer cleavage
M2905_RS01930	COG0300	oxidoreductase activity
M2905_RS01945	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2905_RS01945	COG3443	Belongs to the bacterial solute-binding protein 9 family
M2905_RS01950	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M2905_RS01950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M2905_RS01955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2905_RS01970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M2905_RS01975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2905_RS01980	COG3331	DNA recombination
M2905_RS01985	COG4474	Belongs to the UPF0398 family
M2905_RS02000	COG0116	Belongs to the methyltransferase superfamily
M2905_RS02005	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M2905_RS02015	COG0328	RNA-DNA hybrid ribonuclease activity
M2905_RS02025	COG1278	Cold shock
M2905_RS02040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M2905_RS02045	COG0564	pseudouridine synthase activity
M2905_RS02060	COG0540	Belongs to the ATCase OTCase family
M2905_RS02065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M2905_RS02075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M2905_RS02080	COG0543	2 iron, 2 sulfur cluster binding
M2905_RS02090	COG0284	orotidine-5'-phosphate decarboxylase activity
M2905_RS02105	COG0569	domain protein
M2905_RS02105	COG0475	glutathione-regulated potassium exporter activity
M2905_RS02115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M2905_RS02120	COG0745	RESPONSE REGULATOR receiver
M2905_RS02125	COG5002	protein histidine kinase activity
M2905_RS02130	COG0038	chloride channel
M2905_RS02140	COG1473	amidohydrolase
M2905_RS02145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M2905_RS02160	COG3711	transcriptional antiterminator
M2905_RS02165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2905_RS02175	COG0765	amino acid transport
M2905_RS02180	COG0765	amino acid transport
M2905_RS02185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2905_RS02205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M2905_RS02205	COG2755	lipolytic protein G-D-S-L family
M2905_RS02210	COG0628	permease
M2905_RS02215	COG4479	Belongs to the UPF0346 family
M2905_RS02220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M2905_RS02225	COG4698	Protein conserved in bacteria
M2905_RS02230	COG2755	lipolytic protein G-D-S-L family
M2905_RS02235	COG1307	EDD domain protein, DegV family
M2905_RS02240	COG1272	protein, Hemolysin III
M2905_RS02255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M2905_RS02260	COG0367	asparagine synthase
M2905_RS02270	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M2905_RS02275	COG0488	(ABC) transporter
M2905_RS02280	COG0366	Alpha amylase catalytic
M2905_RS02285	COG0366	Alpha amylase catalytic
M2905_RS02300	COG0617	tRNA 3'-terminal CCA addition
M2905_RS02305	COG1694	Mazg nucleotide pyrophosphohydrolase
M2905_RS02310	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M2905_RS02335	COG1846	Transcriptional regulator
M2905_RS02335	COG0456	acetyltransferase
M2905_RS02340	COG0577	efflux transmembrane transporter activity
M2905_RS02345	COG1136	(ABC) transporter
M2905_RS02350	COG1012	belongs to the aldehyde dehydrogenase family
M2905_RS02355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2905_RS02375	COG2182	Extracellular solute-binding protein
M2905_RS02385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2905_RS02390	COG1323	Belongs to the UPF0348 family
M2905_RS02395	COG0492	ferredoxin-NADP+ reductase activity
M2905_RS02400	COG0534	Mate efflux family protein
M2905_RS02405	COG1132	(ABC) transporter
M2905_RS02410	COG1132	(ABC) transporter
M2905_RS02415	COG3763	UPF0154 protein
M2905_RS02420	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M2905_RS02425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M2905_RS02435	COG1609	Transcriptional regulator
M2905_RS02445	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M2905_RS02450	COG3443	Belongs to the bacterial solute-binding protein 9 family
M2905_RS02450	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2905_RS02455	COG0484	heat shock protein binding
M2905_RS02460	COG0443	Heat shock 70 kDa protein
M2905_RS02465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M2905_RS02470	COG1420	regulation of RNA biosynthetic process
M2905_RS02475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M2905_RS02480	COG0196	riboflavin kinase activity
M2905_RS02485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M2905_RS02495	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M2905_RS02510	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M2905_RS02515	COG0195	Participates in both transcription termination and antitermination
M2905_RS02520	COG0779	Required for maturation of 30S ribosomal subunits
M2905_RS02540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M2905_RS02550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2905_RS02590	COG0481	GTPase activity
M2905_RS02600	COG0542	response to heat
M2905_RS02615	COG2195	Cleaves the N-terminal amino acid of tripeptides
M2905_RS02620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M2905_RS02625	COG2384	SAM-dependent methyltransferase
M2905_RS02640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M2905_RS02645	COG0358	DNA primase activity
M2905_RS02650	COG0751	glycine-tRNA ligase activity
M2905_RS02655	COG0752	glycyl-tRNA synthetase alpha subunit
M2905_RS02660	COG1381	Involved in DNA repair and RecF pathway recombination
M2905_RS02665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M2905_RS02670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M2905_RS02675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M2905_RS02685	COG1702	phosphate starvation-inducible protein PhoH
M2905_RS02690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M2905_RS02695	COG0025	NhaP-type Na H and K H
M2905_RS02710	COG1280	lysine exporter protein (LysE YggA)
M2905_RS02710	COG1674	ftsk spoiiie
M2905_RS02725	COG1464	Belongs to the NlpA lipoprotein family
M2905_RS02730	COG2011	ABC-type metal ion transport system permease component
M2905_RS02735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2905_RS02745	COG1393	Belongs to the ArsC family
M2905_RS02750	COG0772	Belongs to the SEDS family
M2905_RS02770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M2905_RS02775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M2905_RS02780	COG0009	L-threonylcarbamoyladenylate synthase
M2905_RS02785	COG2890	protein-(glutamine-N5) methyltransferase activity
M2905_RS02790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M2905_RS02795	COG1435	thymidine kinase activity
M2905_RS02800	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M2905_RS02805	COG2190	(PTS) system
M2905_RS02805	COG1263	PTS System
M2905_RS02805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS02810	COG0336	Belongs to the RNA methyltransferase TrmD family
M2905_RS02815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M2905_RS02820	COG1837	Belongs to the UPF0109 family
M2905_RS02825	COG0228	four-way junction DNA binding
M2905_RS02830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M2905_RS02835	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M2905_RS02840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M2905_RS02845	COG0436	Aminotransferase
M2905_RS02850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M2905_RS02855	COG0187	DNA topoisomerase II activity
M2905_RS02865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M2905_RS02870	COG0686	Belongs to the AlaDH PNT family
M2905_RS02885	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M2905_RS02890	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M2905_RS02895	COG4974	Belongs to the 'phage' integrase family
M2905_RS02905	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M2905_RS02910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2905_RS02915	COG0758	DNA mediated transformation
M2905_RS02920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M2905_RS02935	COG3409	Peptidoglycan-binding domain 1 protein
M2905_RS02935	COG0793	Belongs to the peptidase S41A family
M2905_RS02945	COG0205	6-phosphofructokinase activity
M2905_RS02950	COG0587	DNA-directed DNA polymerase activity
M2905_RS02960	COG2814	Major facilitator Superfamily
M2905_RS02965	COG2723	6-phospho-beta-galactosidase activity
M2905_RS02970	COG1307	EDD domain protein, DegV family
M2905_RS02980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M2905_RS02990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M2905_RS03000	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M2905_RS03020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M2905_RS03025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M2905_RS03035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M2905_RS03040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M2905_RS03050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M2905_RS03065	COG0668	transmembrane transport
M2905_RS03070	COG1363	Peptidase, m42
M2905_RS03075	COG2233	PERMEase
M2905_RS03080	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
M2905_RS03080	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M2905_RS03095	COG3052	prosthetic group binding
M2905_RS03105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M2905_RS03110	COG0583	DNA-binding transcription factor activity
M2905_RS03120	COG4608	Belongs to the ABC transporter superfamily
M2905_RS03125	COG0444	Belongs to the ABC transporter superfamily
M2905_RS03130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2905_RS03135	COG0601	transmembrane transport
M2905_RS03140	COG0747	negative chemotaxis
M2905_RS03145	COG1473	amidohydrolase
M2905_RS03155	COG0622	Phosphoesterase
M2905_RS03160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M2905_RS03165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M2905_RS03170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2905_RS03170	COG0072	phenylalanine-tRNA ligase activity
M2905_RS03175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M2905_RS03235	COG0791	NLP P60 protein
M2905_RS03235	COG0741	lytic transglycosylase activity
M2905_RS03265	COG2946	Replication initiation factor
M2905_RS03275	COG1674	ftsk spoiiie
M2905_RS03290	COG1733	regulation of RNA biosynthetic process
M2905_RS03300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M2905_RS03305	COG1254	Belongs to the acylphosphatase family
M2905_RS03310	COG0706	membrane insertase activity
M2905_RS03320	COG5002	protein histidine kinase activity
M2905_RS03325	COG0745	RESPONSE REGULATOR receiver
M2905_RS03330	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M2905_RS03335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M2905_RS03345	COG1484	DNA-dependent DNA replication
M2905_RS03355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M2905_RS03360	COG0237	dephospho-CoA kinase activity
M2905_RS03365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M2905_RS03380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M2905_RS03395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M2905_RS03400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M2905_RS03415	COG3091	SprT-like family
M2905_RS03420	COG2183	response to ionizing radiation
M2905_RS03450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2905_RS03455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M2905_RS03460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2905_RS03465	COG4989	oxidoreductase activity
M2905_RS03475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M2905_RS03480	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2905_RS03485	COG1876	peptidase activity
M2905_RS03495	COG4129	membrane
M2905_RS03505	COG2268	Band 7 protein
M2905_RS03535	COG3343	RNA polymerase activity
M2905_RS03545	COG0095	Lipoate-protein ligase
M2905_RS03550	COG1078	dGTPase activity
M2905_RS03570	COG1610	YqeY-like protein
M2905_RS03580	COG0735	belongs to the Fur family
M2905_RS03585	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M2905_RS03590	COG1122	ATPase activity
M2905_RS03595	COG4120	Belongs to the binding-protein-dependent transport system permease family
M2905_RS03610	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M2905_RS03615	COG1950	PFAM Membrane protein of
M2905_RS03635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M2905_RS03640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M2905_RS03645	COG0581	inorganic phosphate transmembrane transporter activity
M2905_RS03650	COG0573	inorganic phosphate transmembrane transporter activity
M2905_RS03655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M2905_RS03660	COG2177	Part of the ABC transporter FtsEX involved in
M2905_RS03665	COG2884	Cell division ATP-binding protein ftsE
M2905_RS03675	COG0653	protein targeting
M2905_RS03690	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M2905_RS03695	COG2267	carboxylic ester hydrolase activity
M2905_RS03705	COG1739	Uncharacterized protein family UPF0029
M2905_RS03710	COG2188	Transcriptional regulator
M2905_RS03715	COG1074	ATP-dependent DNA helicase activity
M2905_RS03720	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M2905_RS03725	COG0681	Belongs to the peptidase S26 family
M2905_RS03735	COG4224	UPF0291 protein
M2905_RS03740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M2905_RS03750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M2905_RS03755	COG0546	phosphoglycolate phosphatase activity
M2905_RS03760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M2905_RS03765	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M2905_RS03795	COG0517	IMP dehydrogenase activity
M2905_RS03830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M2905_RS03840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M2905_RS03850	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M2905_RS03855	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M2905_RS03860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M2905_RS03865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M2905_RS03870	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2905_RS03875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M2905_RS03880	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2905_RS03885	COG0356	it plays a direct role in the translocation of protons across the membrane
M2905_RS03890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M2905_RS03895	COG0557	exoribonuclease II activity
M2905_RS03905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M2905_RS03925	COG0709	Synthesizes selenophosphate from selenide and ATP
M2905_RS03940	COG2261	transglycosylase associated protein
M2905_RS03985	COG1098	S1 RNA binding domain
M2905_RS03995	COG0492	ferredoxin-NADP+ reductase activity
M2905_RS04000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M2905_RS04010	COG0647	UMP catabolic process
M2905_RS04015	COG4470	Protein conserved in bacteria
M2905_RS04025	COG2365	Tyrosine phosphatase family
M2905_RS04040	COG4166	transmembrane transport
M2905_RS04045	COG4608	Belongs to the ABC transporter superfamily
M2905_RS04050	COG0444	Belongs to the ABC transporter superfamily
M2905_RS04055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2905_RS04060	COG0601	transmembrane transport
M2905_RS04080	COG3118	belongs to the thioredoxin family
M2905_RS04085	COG1193	negative regulation of DNA recombination
M2905_RS04100	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M2905_RS04105	COG5294	Protein conserved in bacteria
M2905_RS04115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2905_RS04125	COG3906	Belongs to the UPF0473 family
M2905_RS04135	COG4472	Bacterial protein of unknown function (DUF965)
M2905_RS04140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2905_RS04145	COG0589	response to stress
M2905_RS04150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2905_RS04155	COG1363	Peptidase, m42
M2905_RS04165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M2905_RS04170	COG0510	thiamine kinase activity
M2905_RS04180	COG1131	(ABC) transporter
M2905_RS04185	COG0537	adenosine 5'-monophosphoramidase activity
M2905_RS04195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2905_RS04200	COG3481	metal-dependent phosphohydrolase, HD sub domain
M2905_RS04205	COG3679	Belongs to the UPF0342 family
M2905_RS04210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2905_RS04215	COG0564	pseudouridine synthase activity
M2905_RS04225	COG1438	arginine binding
M2905_RS04230	COG0018	arginyl-trna synthetase
M2905_RS04235	COG4708	membrane
M2905_RS04245	COG1116	anion transmembrane transporter activity
M2905_RS04250	COG4521	taurine ABC transporter
M2905_RS04255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2905_RS04260	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2905_RS04265	COG2391	methyltransferase activity
M2905_RS04270	COG0583	DNA-binding transcription factor activity
M2905_RS04275	COG1597	lipid kinase activity
M2905_RS04285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M2905_RS04290	COG3480	Lon protease (S16) C-terminal proteolytic domain
M2905_RS04295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M2905_RS04300	COG0742	ribosomal rna small subunit methyltransferase
M2905_RS04305	COG4471	UPF0298 protein
M2905_RS04320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M2905_RS04325	COG0772	Belongs to the SEDS family
M2905_RS04330	COG4838	Belongs to the UPF0358 family
M2905_RS04340	COG2116	formate transmembrane transporter activity
M2905_RS04345	COG1464	Belongs to the NlpA lipoprotein family
M2905_RS04350	COG2011	ABC-type metal ion transport system permease component
M2905_RS04360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M2905_RS04365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M2905_RS04370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2905_RS04375	COG1116	anion transmembrane transporter activity
M2905_RS04385	COG0352	thiamine-phosphate diphosphorylase activity
M2905_RS04390	COG0351	phosphomethylpyrimidine kinase
M2905_RS04400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M2905_RS04405	COG0544	peptidyl-prolyl cis-trans isomerase activity
M2905_RS04415	COG1714	RDD family
M2905_RS04425	COG4703	Protein of unknown function (DUF1797)
M2905_RS04435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2905_RS04440	COG3716	PTS system mannose fructose sorbose family IID component
M2905_RS04450	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS04455	COG1105	Belongs to the carbohydrate kinase PfkB family
M2905_RS04460	COG3684	Belongs to the aldolase LacD family
M2905_RS04465	COG2222	sugar isomerase
M2905_RS04470	COG2188	Transcriptional regulator
M2905_RS04475	COG2084	Dehydrogenase
M2905_RS04485	COG0438	transferase activity, transferring glycosyl groups
M2905_RS04490	COG0438	transferase activity, transferring glycosyl groups
M2905_RS04495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M2905_RS04500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2905_RS04510	COG0542	response to heat
M2905_RS04520	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M2905_RS04525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M2905_RS04530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M2905_RS04535	COG0584	glycerophosphoryl diester phosphodiesterase
M2905_RS04545	COG1278	Cold shock
M2905_RS04550	COG2003	Belongs to the UPF0758 family
M2905_RS04555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2905_RS04560	COG0285	dihydrofolate synthase activity
M2905_RS04565	COG0525	valine-tRNA ligase activity
M2905_RS04570	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M2905_RS04575	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M2905_RS04585	COG1104	cysteine desulfurase activity
M2905_RS04590	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M2905_RS04595	COG0561	phosphatase activity
M2905_RS04600	COG1801	Protein of unknown function DUF72
M2905_RS04615	COG0166	Belongs to the GPI family
M2905_RS04620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M2905_RS04625	COG2081	HI0933 family
M2905_RS04645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2905_RS04650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M2905_RS04660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M2905_RS04665	COG1368	sulfuric ester hydrolase activity
M2905_RS04675	COG0765	amino acid transport
M2905_RS04680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2905_RS04690	COG1368	sulfuric ester hydrolase activity
M2905_RS04695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M2905_RS04700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M2905_RS04710	COG0500	methyltransferase
M2905_RS04715	COG3142	Participates in the control of copper homeostasis
M2905_RS04725	COG2239	Acts as a magnesium transporter
M2905_RS04730	COG0564	pseudouridine synthase activity
M2905_RS04735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M2905_RS04740	COG2357	RelA SpoT domain protein
M2905_RS04755	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M2905_RS04760	COG0640	Transcriptional regulator
M2905_RS04765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M2905_RS04770	COG0577	efflux transmembrane transporter activity
M2905_RS04770	COG1136	(ABC) transporter
M2905_RS04775	COG0577	efflux transmembrane transporter activity
M2905_RS04775	COG1136	(ABC) transporter
M2905_RS04785	COG1278	Cold shock
M2905_RS04790	COG1879	ABC-type sugar transport system periplasmic component
M2905_RS04795	COG1172	Belongs to the binding-protein-dependent transport system permease family
M2905_RS04800	COG1129	ABC transporter
M2905_RS04805	COG1869	D-ribose catabolic process
M2905_RS04810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2905_RS04815	COG1609	Transcriptional regulator
M2905_RS04820	COG1253	flavin adenine dinucleotide binding
M2905_RS04825	COG0628	permease
M2905_RS04845	COG3557	Belongs to the UPF0374 family
M2905_RS04890	COG0392	lysyltransferase activity
M2905_RS04890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M2905_RS04895	COG1194	a g-specific adenine glycosylase
M2905_RS04900	COG2137	regulation of response to DNA damage stimulus
M2905_RS04925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M2905_RS04930	COG1316	TRANSCRIPTIONal
M2905_RS04945	COG0728	peptidoglycan biosynthetic process
M2905_RS04955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2905_RS04965	COG0438	transferase activity, transferring glycosyl groups
M2905_RS04965	COG0297	glycogen (starch) synthase activity
M2905_RS04975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M2905_RS04980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M2905_RS04990	COG4464	protein tyrosine phosphatase activity
M2905_RS04995	COG0489	protein tyrosine kinase activity
M2905_RS05000	COG3944	biosynthesis protein
M2905_RS05030	COG0860	N-Acetylmuramoyl-L-alanine amidase
M2905_RS05055	COG1091	dTDP-4-dehydrorhamnose reductase activity
M2905_RS05070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M2905_RS05075	COG1442	glycosyl transferase family 8
M2905_RS05075	COG1216	Glycosyl transferase, family 2
M2905_RS05090	COG1316	TRANSCRIPTIONal
M2905_RS05095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2905_RS05100	COG0438	transferase activity, transferring glycosyl groups
M2905_RS05100	COG1216	Glycosyl transferase, family 2
M2905_RS05105	COG0438	transferase activity, transferring glycosyl groups
M2905_RS05105	COG1216	Glycosyl transferase, family 2
M2905_RS05110	COG1134	teichoic acid transport
M2905_RS05115	COG1682	transport, permease protein
M2905_RS05120	COG1368	sulfuric ester hydrolase activity
M2905_RS05125	COG1295	ribonuclease BN
M2905_RS05130	COG0024	Methionine aminopeptidase
M2905_RS05135	COG0716	FMN binding
M2905_RS05145	COG2309	aminopeptidase activity
M2905_RS05170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2905_RS05180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2905_RS05185	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M2905_RS05185	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M2905_RS05195	COG0673	inositol 2-dehydrogenase activity
M2905_RS05205	COG1132	(ABC) transporter
M2905_RS05215	COG5503	Protein of unknown function (DUF1447)
M2905_RS05225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M2905_RS05230	COG1940	carbohydrate kinase activity
M2905_RS05235	COG0705	Rhomboid family
M2905_RS05235	COG0457	Tetratricopeptide repeat
M2905_RS05250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M2905_RS05255	COG0768	penicillin binding
M2905_RS05260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M2905_RS05270	COG1185	polyribonucleotide nucleotidyltransferase activity
M2905_RS05275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M2905_RS05280	COG0242	peptide deformylase activity
M2905_RS05290	COG2207	Transcriptional regulator
M2905_RS05300	COG0737	Belongs to the 5'-nucleotidase family
M2905_RS05305	COG1737	Transcriptional regulator
M2905_RS05310	COG0114	fumarate hydratase activity
M2905_RS05315	COG0281	malic enzyme
M2905_RS05320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M2905_RS05325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS05325	COG1263	PTS System
M2905_RS05330	COG0656	L-ascorbic acid biosynthetic process
M2905_RS05335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M2905_RS05345	COG3842	ATPase activity
M2905_RS05355	COG4753	response regulator
M2905_RS05355	COG2207	Transcriptional regulator
M2905_RS05360	COG2972	Histidine kinase
M2905_RS05365	COG0459	protein refolding
M2905_RS05370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M2905_RS05375	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M2905_RS05380	COG0488	(ABC) transporter
M2905_RS05390	COG1609	Transcriptional regulator
M2905_RS05400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M2905_RS05405	COG4109	DRTGG domain
M2905_RS05410	COG2814	Major facilitator Superfamily
M2905_RS05420	COG1132	(ABC) transporter
M2905_RS05425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M2905_RS05430	COG0204	Acyl-transferase
M2905_RS05435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M2905_RS05440	COG2827	Endonuclease containing a URI domain
M2905_RS05460	COG1959	2 iron, 2 sulfur cluster binding
M2905_RS05465	COG1288	antiporter activity
M2905_RS05470	COG2376	Dihydroxyacetone kinase
M2905_RS05475	COG1461	Dihydroxyacetone kinase
M2905_RS05480	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
M2905_RS05490	COG2376	Dihydroxyacetone kinase
M2905_RS05510	COG0456	acetyltransferase
M2905_RS05520	COG1309	transcriptional regulator
M2905_RS05545	COG2390	Transcriptional regulator
M2905_RS05550	COG3634	alkyl hydroperoxide reductase activity
M2905_RS05555	COG0450	alkyl hydroperoxide reductase
M2905_RS05565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M2905_RS05570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M2905_RS05575	COG0183	Belongs to the thiolase family
M2905_RS05580	COG1136	(ABC) transporter
M2905_RS05585	COG0577	efflux transmembrane transporter activity
M2905_RS05605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2905_RS05750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M2905_RS05755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M2905_RS05760	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M2905_RS05765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M2905_RS05770	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M2905_RS05775	COG0037	tRNA processing
M2905_RS05780	COG1098	S1 RNA binding domain
M2905_RS05790	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M2905_RS05795	COG2244	polysaccharide biosynthetic process
M2905_RS05800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M2905_RS05805	COG0193	aminoacyl-tRNA hydrolase activity
M2905_RS05815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M2905_RS05820	COG1780	Probably involved in ribonucleotide reductase function
M2905_RS05825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2905_RS05830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2905_RS05840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M2905_RS05845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M2905_RS05850	COG4684	Psort location CytoplasmicMembrane, score
M2905_RS05855	COG4862	establishment of competence for transformation
M2905_RS05860	COG1393	Belongs to the ArsC family
M2905_RS05865	COG0180	Tryptophanyl-tRNA synthetase
M2905_RS05870	COG0095	Lipoate-protein ligase
M2905_RS05875	COG1234	tRNA 3'-trailer cleavage
M2905_RS05880	COG1363	Peptidase, m42
M2905_RS05890	COG1328	CTP reductase activity
M2905_RS05895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M2905_RS05900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M2905_RS05905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M2905_RS05910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M2905_RS05925	COG2249	NAD(P)H dehydrogenase (quinone) activity
M2905_RS05955	COG0572	uridine kinase
M2905_RS05960	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M2905_RS05995	COG4537	Required for transformation and DNA binding
M2905_RS06000	COG1459	type II secretion system
M2905_RS06005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M2905_RS06015	COG0217	transcriptional regulatory protein
M2905_RS06025	COG3688	RNA-binding protein containing a PIN domain
M2905_RS06035	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M2905_RS06040	COG0215	cysteine-tRNA ligase activity
M2905_RS06045	COG1045	serine acetyltransferase
M2905_RS06050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M2905_RS06055	COG4956	integral membrane protein (PIN domain superfamily)
M2905_RS06065	COG0756	dUTP diphosphatase activity
M2905_RS06070	COG1937	Protein conserved in bacteria
M2905_RS06075	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2905_RS06085	COG1187	pseudouridine synthase activity
M2905_RS06090	COG2244	polysaccharide biosynthetic process
M2905_RS06095	COG1363	Peptidase, m42
M2905_RS06105	COG4493	Belongs to the UPF0637 family
M2905_RS06110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M2905_RS06130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2905_RS06135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2905_RS06140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M2905_RS06145	COG0124	histidyl-tRNA synthetase
M2905_RS06150	COG0860	N-Acetylmuramoyl-L-alanine amidase
M2905_RS06150	COG4991	sh3 domain protein
M2905_RS06150	COG3103	Sh3 type 3 domain protein
M2905_RS06155	COG1490	D-aminoacyl-tRNA deacylase activity
M2905_RS06160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M2905_RS06185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M2905_RS06190	COG2264	protein methyltransferase activity
M2905_RS06200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M2905_RS06215	COG0589	response to stress
M2905_RS06220	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2905_RS06225	COG0737	Belongs to the 5'-nucleotidase family
M2905_RS06230	COG3639	organic phosphonate transmembrane transporter activity
M2905_RS06265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2905_RS06280	COG3859	Proton-coupled thiamine transporter YuaJ
M2905_RS06285	COG2076	Multidrug Resistance protein
M2905_RS06290	COG2076	Multidrug Resistance protein
M2905_RS06305	COG1482	cell wall glycoprotein biosynthetic process
M2905_RS06310	COG1940	carbohydrate kinase activity
M2905_RS06320	COG0395	ABC-type sugar transport system, permease component
M2905_RS06325	COG4209	transmembrane transport
M2905_RS06355	COG2723	6-phospho-beta-galactosidase activity
M2905_RS06360	COG0456	acetyltransferase
M2905_RS06375	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M2905_RS06375	COG3291	Pkd domain containing protein
M2905_RS06390	COG0488	(ABC) transporter
M2905_RS06400	COG0477	Major facilitator Superfamily
M2905_RS06410	COG2003	Belongs to the UPF0758 family
M2905_RS06425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2905_RS06435	COG3973	AAA domain
M2905_RS06455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M2905_RS06460	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M2905_RS06465	COG1686	Belongs to the peptidase S11 family
M2905_RS06470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M2905_RS06485	COG0395	ABC-type sugar transport system, permease component
M2905_RS06490	COG4209	transmembrane transport
M2905_RS06500	COG1653	transport
M2905_RS06505	COG2207	Transcriptional regulator
M2905_RS06505	COG4753	response regulator
M2905_RS06510	COG3275	phosphorelay sensor kinase activity
M2905_RS06515	COG0673	inositol 2-dehydrogenase activity
M2905_RS06545	COG2207	Transcriptional regulator
M2905_RS06550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS06550	COG1263	PTS System
M2905_RS06555	COG1486	melibiose metabolic process
M2905_RS06560	COG1737	Transcriptional regulator
M2905_RS06575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M2905_RS06605	COG0582	viral genome integration into host DNA
M2905_RS06610	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M2905_RS06615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M2905_RS06620	COG0101	tRNA pseudouridine synthase activity
M2905_RS06630	COG1122	ATPase activity
M2905_RS06635	COG1122	ATPase activity
M2905_RS06640	COG0203	ribosomal protein L17
M2905_RS06645	COG0202	RNA polymerase activity
M2905_RS06650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M2905_RS06655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M2905_RS06660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M2905_RS06670	COG0563	adenylate kinase activity
M2905_RS06675	COG0201	protein transport
M2905_RS06680	COG0200	Binds to the 23S rRNA
M2905_RS06685	COG1841	ribosomal large subunit assembly
M2905_RS06690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M2905_RS06700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M2905_RS06705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M2905_RS06710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M2905_RS06715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M2905_RS06720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M2905_RS06725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M2905_RS06730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M2905_RS06735	COG0255	Belongs to the universal ribosomal protein uL29 family
M2905_RS06740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M2905_RS06745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M2905_RS06750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M2905_RS06760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M2905_RS06765	COG0089	rRNA binding
M2905_RS06770	COG0088	Forms part of the polypeptide exit tunnel
M2905_RS06775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M2905_RS06780	COG0051	transcription antitermination factor activity, RNA binding
M2905_RS06790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M2905_RS06795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M2905_RS06800	COG0049	tRNA binding
M2905_RS06805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M2905_RS06810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M2905_RS06815	COG0813	purine-nucleoside phosphorylase activity
M2905_RS06820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M2905_RS06825	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M2905_RS06830	COG1079	Belongs to the binding-protein-dependent transport system permease family
M2905_RS06835	COG4603	Belongs to the binding-protein-dependent transport system permease family
M2905_RS06840	COG3845	ABC transporter
M2905_RS06845	COG1744	ABC transporter substrate-binding protein PnrA-like
M2905_RS06850	COG0295	cytidine deaminase activity
M2905_RS06855	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M2905_RS06870	COG4120	Belongs to the binding-protein-dependent transport system permease family
M2905_RS06875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2905_RS06880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M2905_RS06880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M2905_RS06895	COG4939	FMN-binding domain protein
M2905_RS06915	COG0488	(ABC) transporter
M2905_RS06920	COG0305	Participates in initiation and elongation during chromosome replication
M2905_RS06925	COG0359	binds to the 23S rRNA
M2905_RS06930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M2905_RS06940	COG0360	Binds together with S18 to 16S ribosomal RNA
M2905_RS06955	COG0187	DNA topoisomerase II activity
M2905_RS06960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M2905_RS06965	COG2501	S4 domain
M2905_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
M2905_RS06985	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M2905_RS06990	COG1414	Transcriptional regulator
M2905_RS06995	COG0800	Aldolase
M2905_RS07000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2905_RS07005	COG5492	domain, Protein
M2905_RS07020	COG3716	PTS system mannose fructose sorbose family IID component
M2905_RS07025	COG3715	PTS system
M2905_RS07035	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M2905_RS07040	COG2188	Transcriptional regulator
M2905_RS07045	COG0592	DNA-directed DNA polymerase activity
M2905_RS07050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M2905_RS07055	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M2905_RS07065	COG0706	membrane insertase activity
M2905_RS07075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2905_RS07080	COG0445	tRNA wobble uridine modification
M2905_RS07105	COG0357	Ribosomal RNA small subunit methyltransferase G
M2905_RS07110	COG1192	Involved in chromosome partitioning
M2905_RS07115	COG1475	DNA binding
M2905_RS07120	COG4481	Protein conserved in bacteria
M2905_RS07125	COG0012	GTP binding
M2905_RS07135	COG0516	GMP reductase activity
M2905_RS07135	COG0517	IMP dehydrogenase activity
M2905_RS07140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M2905_RS07145	COG1686	Belongs to the peptidase S11 family
M2905_RS07160	COG0406	alpha-ribazole phosphatase activity
M2905_RS07220	COG4463	regulation of RNA biosynthetic process
M2905_RS07225	COG0542	response to heat
M2905_RS07235	COG0826	peptidase U32
M2905_RS07245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2905_RS07250	COG1271	oxidase subunit
M2905_RS07255	COG1294	oxidase, subunit
M2905_RS07260	COG4988	ABC transporter
M2905_RS07265	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M2905_RS07275	COG0142	geranyltranstransferase activity
M2905_RS07290	COG0561	phosphatase activity
M2905_RS07295	COG0280	phosphate acetyltransferase
M2905_RS07300	COG0802	atpase or kinase
M2905_RS07305	COG0737	Belongs to the 5'-nucleotidase family
M2905_RS07320	COG0708	Exodeoxyribonuclease III
M2905_RS07325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M2905_RS07330	COG0604	alcohol dehydrogenase
M2905_RS07340	COG3842	ATPase activity
M2905_RS07345	COG1176	ABC-type spermidine putrescine transport system, permease component I
M2905_RS07350	COG1177	transmembrane transport
M2905_RS07355	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M2905_RS07360	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M2905_RS07365	COG1263	PTS System
M2905_RS07365	COG2190	(PTS) system
M2905_RS07365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS07370	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2905_RS07375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M2905_RS07380	COG1121	(ABC) transporter
M2905_RS07385	COG1121	(ABC) transporter
M2905_RS07390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M2905_RS07395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2905_RS07405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M2905_RS07410	COG1970	mechanosensitive ion channel activity
M2905_RS07415	COG0612	Peptidase, M16
M2905_RS07420	COG0612	Peptidase, M16
M2905_RS07430	COG1426	Protein conserved in bacteria
M2905_RS07435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M2905_RS07440	COG1546	Belongs to the CinA family
M2905_RS07440	COG1058	Belongs to the CinA family
M2905_RS07445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M2905_RS07450	COG1418	mRNA catabolic process
M2905_RS07465	COG1278	Cold shock
M2905_RS07480	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M2905_RS07485	COG1263	PTS System
M2905_RS07485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS07490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2905_RS07495	COG1737	Transcriptional regulator
M2905_RS07500	COG3973	AAA domain
M2905_RS07505	COG0745	RESPONSE REGULATOR receiver
M2905_RS07510	COG5002	protein histidine kinase activity
M2905_RS07525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M2905_RS07530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M2905_RS07535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M2905_RS07555	COG0625	glutathione transferase activity
M2905_RS07560	COG0590	tRNA wobble adenosine to inosine editing
M2905_RS07565	COG2190	(PTS) system
M2905_RS07565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS07565	COG1263	PTS System
M2905_RS07570	COG3711	transcriptional antiterminator
M2905_RS07575	COG2723	6-phospho-beta-galactosidase activity
M2905_RS07585	COG1285	pathogenesis
M2905_RS07590	COG2814	Major facilitator Superfamily
M2905_RS07595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M2905_RS07595	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M2905_RS07600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2905_RS07600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS07610	COG3715	PTS system
M2905_RS07615	COG3716	PTS system mannose fructose sorbose family IID component
M2905_RS07650	COG1122	ATPase activity
M2905_RS07665	COG0463	Glycosyl transferase, family 2
M2905_RS07680	COG0402	S-adenosylhomocysteine deaminase activity
M2905_RS07685	COG0463	Glycosyl transferase, family 2
M2905_RS07690	COG4619	ABC transporter
M2905_RS07695	COG0390	transport system, permease component
M2905_RS07705	COG0583	DNA-binding transcription factor activity
M2905_RS07710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M2905_RS07720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2905_RS07730	COG2910	NAD(P)H-binding
M2905_RS07735	COG1733	regulation of RNA biosynthetic process
M2905_RS07740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2905_RS07745	COG2233	PERMEase
M2905_RS07750	COG2190	(PTS) system
M2905_RS07750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS07750	COG1263	PTS System
M2905_RS07755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M2905_RS07760	COG1609	Transcriptional regulator
M2905_RS07770	COG1621	beta-fructofuranosidase activity
M2905_RS07780	COG0668	transmembrane transport
M2905_RS07810	COG0156	8-amino-7-oxononanoate synthase activity
M2905_RS07815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2905_RS07825	COG1979	alcohol dehydrogenase
M2905_RS07830	COG0383	alpha-mannosidase activity
M2905_RS07860	COG1054	Belongs to the UPF0176 family
M2905_RS07865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M2905_RS07870	COG2094	Belongs to the DNA glycosylase MPG family
M2905_RS07880	COG1378	Sugar-specific transcriptional regulator TrmB
M2905_RS07895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2905_RS07895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M2905_RS07895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M2905_RS07900	COG1105	Belongs to the carbohydrate kinase PfkB family
M2905_RS07905	COG1349	DNA-binding transcription factor activity
M2905_RS07910	COG1692	metallophosphoesterase
M2905_RS07920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M2905_RS07925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M2905_RS07930	COG0424	maF-like protein
M2905_RS07950	COG1418	mRNA catabolic process
M2905_RS07965	COG1346	cytolysis
M2905_RS07970	COG0517	IMP dehydrogenase activity
M2905_RS07975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M2905_RS07980	COG1597	lipid kinase activity
M2905_RS07995	COG0561	phosphatase activity
M2905_RS08000	COG0745	RESPONSE REGULATOR receiver
M2905_RS08005	COG5002	protein histidine kinase activity
M2905_RS08005	COG3850	Histidine kinase
M2905_RS08010	COG4476	Belongs to the UPF0223 family
M2905_RS08015	COG0483	inositol monophosphate 1-phosphatase activity
M2905_RS08020	COG1217	gtp-binding protein TYPA
M2905_RS08045	COG0191	fructose-bisphosphate aldolase activity
M2905_RS08060	COG2706	6-phosphogluconolactonase activity
M2905_RS08070	COG0628	permease
M2905_RS08075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M2905_RS08100	COG2824	Alkylphosphonate utilization operon protein PhnA
M2905_RS08105	COG2738	Putative neutral zinc metallopeptidase
M2905_RS08115	COG2508	Transcriptional regulator
M2905_RS08120	COG0590	tRNA wobble adenosine to inosine editing
M2905_RS08145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M2905_RS08150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M2905_RS08155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M2905_RS08160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M2905_RS08165	COG3870	Protein conserved in bacteria
M2905_RS08170	COG0470	DNA polymerase III
M2905_RS08175	COG1774	PSP1 C-terminal conserved region
M2905_RS08180	COG4467	Involved in initiation control of chromosome replication
M2905_RS08220	COG1132	(ABC) transporter
M2905_RS08225	COG1132	(ABC) transporter
M2905_RS08230	COG4475	Protein of unknown function (DUF436)
M2905_RS08235	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M2905_RS08245	COG0765	amino acid transport
M2905_RS08255	COG4717	serine-type aminopeptidase activity
M2905_RS08265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M2905_RS08270	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M2905_RS08280	COG1596	polysaccharide export
M2905_RS08280	COG1555	photosystem II stabilization
M2905_RS08285	COG2131	deaminase
M2905_RS08290	COG0658	competence protein
M2905_RS08290	COG2333	competence protein COMEC
M2905_RS08295	COG1466	dna polymerase III delta subunit
M2905_RS08300	COG0268	Binds directly to 16S ribosomal RNA
M2905_RS08305	COG0306	phosphate transporter
M2905_RS08310	COG1392	Phosphate transport regulator
M2905_RS08320	COG2217	Heavy metal translocating P-type atpase
M2905_RS08325	COG1968	undecaprenyl-diphosphatase activity
M2905_RS08330	COG2207	Transcriptional regulator
M2905_RS08335	COG0673	inositol 2-dehydrogenase activity
M2905_RS08345	COG1082	Xylose isomerase domain protein TIM barrel
M2905_RS08350	COG0673	inositol 2-dehydrogenase activity
M2905_RS08355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M2905_RS08385	COG1732	Glycine betaine
M2905_RS08390	COG1174	glycine betaine transport
M2905_RS08395	COG0436	Aminotransferase
M2905_RS08415	COG0110	maltose O-acetyltransferase activity
M2905_RS08420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2905_RS08430	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M2905_RS08440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M2905_RS08440	COG0574	Belongs to the PEP-utilizing enzyme family
M2905_RS08445	COG0584	glycerophosphoryl diester phosphodiesterase
M2905_RS08450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2905_RS08450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2905_RS08455	COG0084	hydrolase, TatD family'
M2905_RS08460	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M2905_RS08465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2905_RS08470	COG3842	ATPase activity
M2905_RS08475	COG1803	Methylglyoxal synthase
M2905_RS08480	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M2905_RS08485	COG0827	DNA restriction-modification system
M2905_RS08490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M2905_RS08495	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M2905_RS08500	COG4605	iron ion homeostasis
M2905_RS08505	COG4604	ABC transporter, ATP-binding protein
M2905_RS08510	COG4607	ABC-type enterochelin transport system periplasmic component
M2905_RS08525	COG1942	4-Oxalocrotonate Tautomerase
M2905_RS08530	COG1349	DNA-binding transcription factor activity
M2905_RS08535	COG1012	belongs to the aldehyde dehydrogenase family
M2905_RS08540	COG3718	enzyme involved in inositol metabolism
M2905_RS08545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2905_RS08550	COG3962	Belongs to the TPP enzyme family
M2905_RS08555	COG0673	inositol 2-dehydrogenase activity
M2905_RS08560	COG1082	Xylose isomerase domain protein TIM barrel
M2905_RS08565	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M2905_RS08570	COG0673	inositol 2-dehydrogenase activity
M2905_RS08580	COG0632	four-way junction helicase activity
M2905_RS08585	COG2255	four-way junction helicase activity
M2905_RS08590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M2905_RS08595	COG0343	queuine tRNA-ribosyltransferase activity
M2905_RS08600	COG1862	Preprotein translocase
M2905_RS08610	COG1454	alcohol dehydrogenase
M2905_RS08610	COG1012	belongs to the aldehyde dehydrogenase family
M2905_RS08635	COG1164	Oligoendopeptidase f
M2905_RS08645	COG4466	Protein conserved in bacteria
M2905_RS08650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2905_RS08655	COG2188	Transcriptional regulator
M2905_RS08660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2905_RS08665	COG1446	asparaginase
M2905_RS08705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M2905_RS08710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2905_RS08725	COG1959	2 iron, 2 sulfur cluster binding
M2905_RS08730	COG2188	Transcriptional regulator
M2905_RS08735	COG0366	Alpha amylase catalytic
M2905_RS08740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2905_RS08740	COG1263	PTS System
M2905_RS08765	COG0789	Transcriptional regulator
M2905_RS08775	COG2188	Transcriptional regulator
M2905_RS08780	COG2723	6-phospho-beta-galactosidase activity
M2905_RS08785	COG0739	heme binding
M2905_RS08785	COG0741	lytic transglycosylase activity
M2905_RS08785	COG1196	nuclear chromosome segregation
M2905_RS08790	COG0726	polysaccharide deacetylase
M2905_RS08810	COG3284	Transcriptional regulator
M2905_RS08815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2905_RS08820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M2905_RS08825	COG0022	dehydrogenase e1 component
M2905_RS08830	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2905_RS08835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M2905_RS08835	COG0519	Catalyzes the synthesis of GMP from XMP
M2905_RS08840	COG1072	(Pantothenic acid kinase))
M2905_RS08845	COG1607	acyl-coa hydrolase
M2905_RS08855	COG2813	Specifically methylates the guanine in position
M2905_RS08860	COG0052	Belongs to the universal ribosomal protein uS2 family
M2905_RS08865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M2905_RS08870	COG0528	UMP kinase activity
M2905_RS08875	COG0233	cytoplasmic translational termination
M2905_RS08880	COG0038	chloride channel
M2905_RS08885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M2905_RS08890	COG4589	Belongs to the CDS family
M2905_RS08895	COG0750	zinc metalloprotease
M2905_RS08900	COG0442	prolyl-tRNA aminoacylation
M2905_RS08905	COG2176	DNA-directed DNA polymerase activity
M2905_RS08910	COG0735	belongs to the Fur family
M2905_RS08990	COG0322	excinuclease ABC activity
M2905_RS09000	COG4152	abc transporter atp-binding protein
M2905_RS09005	COG1668	transmembrane transport
M2905_RS09010	COG0210	DNA helicase
M2905_RS09015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M2905_RS09020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2905_RS09025	COG0154	amidase activity
M2905_RS09030	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2905_RS09035	COG1597	lipid kinase activity
M2905_RS09040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M2905_RS09060	COG0488	(ABC) transporter
M2905_RS09080	COG2226	methyltransferase
M2905_RS09090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2905_RS09110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M2905_RS09125	COG2608	mercury ion transmembrane transporter activity
M2905_RS09130	COG1114	Component of the transport system for branched-chain amino acids
M2905_RS09145	COG1132	(ABC) transporter
M2905_RS09155	COG1686	Belongs to the peptidase S11 family
M2905_RS09160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M2905_RS09165	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M2905_RS09170	COG0254	rRNA binding
M2905_RS09175	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2905_RS09175	COG1388	LysM domain
M2905_RS09180	COG2017	converts alpha-aldose to the beta-anomer
M2905_RS09185	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
M2905_RS09195	COG0589	response to stress
M2905_RS09210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M2905_RS09220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M2905_RS09225	COG0006	proline dipeptidase activity
M2905_RS09230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M2905_RS09235	COG1302	Protein conserved in bacteria
M2905_RS09240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2905_RS09245	COG1570	exodeoxyribonuclease VII activity
M2905_RS09250	COG1722	exodeoxyribonuclease VII activity
M2905_RS09255	COG0142	geranyltranstransferase activity
M2905_RS09260	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M2905_RS09265	COG1438	arginine binding
M2905_RS09270	COG0497	DNA recombination
M2905_RS09285	COG2001	Belongs to the MraZ family
M2905_RS09290	COG0275	rRNA processing
M2905_RS09300	COG0768	penicillin binding
M2905_RS09305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2905_RS09310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M2905_RS09315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M2905_RS09320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M2905_RS09325	COG0849	cell division
M2905_RS09335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M2905_RS09340	COG1799	cell septum assembly
M2905_RS09350	COG2302	S4 RNA-binding domain
M2905_RS09355	COG3599	regulation of cell shape
M2905_RS09360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M2905_RS09385	COG1203	CRISPR-associated helicase, Cas3
M2905_RS09395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M2905_RS09405	COG0250	Participates in transcription elongation, termination and antitermination
M2905_RS09410	COG3123	guanosine phosphorylase activity
M2905_RS09415	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M2905_RS09435	COG1396	sequence-specific DNA binding
M2905_RS09440	COG1760	l-serine dehydratase
M2905_RS09445	COG1760	l-serine dehydratase
M2905_RS09450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M2905_RS09455	COG0081	regulation of translation
M2905_RS09460	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M2905_RS09465	COG0222	ribosome binding
M2905_RS09475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M2905_RS09480	COG0477	Major facilitator Superfamily
M2905_RS09485	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M2905_RS09490	COG1242	4 iron, 4 sulfur cluster binding
M2905_RS09495	COG0671	phosphoesterase, PA-phosphatase related
M2905_RS09520	COG1388	LysM domain
M2905_RS09520	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2905_RS09525	COG0495	leucyl-tRNA aminoacylation
M2905_RS09530	COG1671	Belongs to the UPF0178 family
M2905_RS09535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M2905_RS09540	COG3764	Sortase (surface protein transpeptidase)
M2905_RS09550	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2905_RS09555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity