locus-tag	class	description
M2908_RS00010	COG4129	membrane
M2908_RS00020	COG1876	peptidase activity
M2908_RS00025	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2908_RS00030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M2908_RS00040	COG4989	oxidoreductase activity
M2908_RS00045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2908_RS00050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M2908_RS00055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2908_RS00085	COG2183	response to ionizing radiation
M2908_RS00090	COG3091	SprT-like family
M2908_RS00105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M2908_RS00110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M2908_RS00125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M2908_RS00140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M2908_RS00145	COG0237	dephospho-CoA kinase activity
M2908_RS00150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M2908_RS00160	COG1484	DNA-dependent DNA replication
M2908_RS00170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M2908_RS00175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M2908_RS00180	COG0745	RESPONSE REGULATOR receiver
M2908_RS00185	COG5002	protein histidine kinase activity
M2908_RS00195	COG0706	membrane insertase activity
M2908_RS00200	COG1254	Belongs to the acylphosphatase family
M2908_RS00205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M2908_RS00215	COG1733	regulation of RNA biosynthetic process
M2908_RS00220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M2908_RS00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2908_RS00225	COG0072	phenylalanine-tRNA ligase activity
M2908_RS00230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M2908_RS00235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M2908_RS00240	COG0622	Phosphoesterase
M2908_RS00250	COG1473	amidohydrolase
M2908_RS00255	COG0747	negative chemotaxis
M2908_RS00260	COG0601	transmembrane transport
M2908_RS00265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2908_RS00270	COG0444	Belongs to the ABC transporter superfamily
M2908_RS00275	COG4608	Belongs to the ABC transporter superfamily
M2908_RS00285	COG0583	DNA-binding transcription factor activity
M2908_RS00290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M2908_RS00300	COG3052	prosthetic group binding
M2908_RS00315	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M2908_RS00315	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
M2908_RS00320	COG2233	PERMEase
M2908_RS00325	COG1363	Peptidase, m42
M2908_RS00330	COG0668	transmembrane transport
M2908_RS00345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M2908_RS00355	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M2908_RS00360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M2908_RS00370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M2908_RS00375	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M2908_RS00395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M2908_RS00405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M2908_RS00415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M2908_RS00425	COG1307	EDD domain protein, DegV family
M2908_RS00430	COG2723	6-phospho-beta-galactosidase activity
M2908_RS00435	COG2814	Major facilitator Superfamily
M2908_RS00445	COG0587	DNA-directed DNA polymerase activity
M2908_RS00450	COG0205	6-phosphofructokinase activity
M2908_RS00460	COG3409	Peptidoglycan-binding domain 1 protein
M2908_RS00460	COG0793	Belongs to the peptidase S41A family
M2908_RS00475	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M2908_RS00480	COG0758	DNA mediated transformation
M2908_RS00485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2908_RS00490	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M2908_RS00500	COG4974	Belongs to the 'phage' integrase family
M2908_RS00505	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M2908_RS00510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M2908_RS00515	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M2908_RS00525	COG0686	Belongs to the AlaDH PNT family
M2908_RS00530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M2908_RS00540	COG0187	DNA topoisomerase II activity
M2908_RS00545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M2908_RS00550	COG0436	Aminotransferase
M2908_RS00555	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M2908_RS00560	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M2908_RS00565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M2908_RS00570	COG0228	four-way junction DNA binding
M2908_RS00575	COG1837	Belongs to the UPF0109 family
M2908_RS00580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M2908_RS00585	COG0336	Belongs to the RNA methyltransferase TrmD family
M2908_RS00590	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M2908_RS00595	COG1435	thymidine kinase activity
M2908_RS00600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M2908_RS00605	COG2890	protein-(glutamine-N5) methyltransferase activity
M2908_RS00610	COG0009	L-threonylcarbamoyladenylate synthase
M2908_RS00615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M2908_RS00620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M2908_RS00640	COG0772	Belongs to the SEDS family
M2908_RS00645	COG1393	Belongs to the ArsC family
M2908_RS00650	COG0509	glycine decarboxylation via glycine cleavage system
M2908_RS00655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2908_RS00660	COG2011	ABC-type metal ion transport system permease component
M2908_RS00665	COG1464	Belongs to the NlpA lipoprotein family
M2908_RS00680	COG1280	lysine exporter protein (LysE YggA)
M2908_RS00680	COG1674	ftsk spoiiie
M2908_RS00695	COG0025	NhaP-type Na H and K H
M2908_RS00700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M2908_RS00705	COG1702	phosphate starvation-inducible protein PhoH
M2908_RS00715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M2908_RS00720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M2908_RS00725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M2908_RS00730	COG1381	Involved in DNA repair and RecF pathway recombination
M2908_RS00735	COG0752	glycyl-tRNA synthetase alpha subunit
M2908_RS00740	COG0751	glycine-tRNA ligase activity
M2908_RS00745	COG0358	DNA primase activity
M2908_RS00750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M2908_RS00765	COG2384	SAM-dependent methyltransferase
M2908_RS00770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M2908_RS00775	COG2195	Cleaves the N-terminal amino acid of tripeptides
M2908_RS00790	COG0542	response to heat
M2908_RS00800	COG0481	GTPase activity
M2908_RS00805	COG4974	Belongs to the 'phage' integrase family
M2908_RS00855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2908_RS00865	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M2908_RS00885	COG0779	Required for maturation of 30S ribosomal subunits
M2908_RS00890	COG0195	Participates in both transcription termination and antitermination
M2908_RS00895	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M2908_RS00910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M2908_RS00915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M2908_RS00920	COG0196	riboflavin kinase activity
M2908_RS00925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M2908_RS00930	COG1420	regulation of RNA biosynthetic process
M2908_RS00935	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M2908_RS00940	COG0443	Heat shock 70 kDa protein
M2908_RS00945	COG0484	heat shock protein binding
M2908_RS00950	COG3443	Belongs to the bacterial solute-binding protein 9 family
M2908_RS00950	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2908_RS00955	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M2908_RS00965	COG1609	Transcriptional regulator
M2908_RS00975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M2908_RS00980	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M2908_RS00985	COG3763	UPF0154 protein
M2908_RS00990	COG1132	(ABC) transporter
M2908_RS00995	COG1132	(ABC) transporter
M2908_RS01000	COG0534	Mate efflux family protein
M2908_RS01005	COG0492	ferredoxin-NADP+ reductase activity
M2908_RS01010	COG1323	Belongs to the UPF0348 family
M2908_RS01015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2908_RS01025	COG2182	Extracellular solute-binding protein
M2908_RS01045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2908_RS01050	COG1012	belongs to the aldehyde dehydrogenase family
M2908_RS01055	COG1136	(ABC) transporter
M2908_RS01060	COG0577	efflux transmembrane transporter activity
M2908_RS01065	COG1846	Transcriptional regulator
M2908_RS01065	COG0456	acetyltransferase
M2908_RS01090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M2908_RS01095	COG1694	Mazg nucleotide pyrophosphohydrolase
M2908_RS01100	COG0617	tRNA 3'-terminal CCA addition
M2908_RS01115	COG0366	Alpha amylase catalytic
M2908_RS01120	COG0366	Alpha amylase catalytic
M2908_RS01125	COG0488	(ABC) transporter
M2908_RS01130	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M2908_RS01140	COG0367	asparagine synthase
M2908_RS01145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M2908_RS01160	COG1272	protein, Hemolysin III
M2908_RS01165	COG1307	EDD domain protein, DegV family
M2908_RS01170	COG2755	lipolytic protein G-D-S-L family
M2908_RS01175	COG4698	Protein conserved in bacteria
M2908_RS01180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M2908_RS01190	COG0628	permease
M2908_RS01195	COG2755	lipolytic protein G-D-S-L family
M2908_RS01195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M2908_RS01215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2908_RS01220	COG0765	amino acid transport
M2908_RS01225	COG0765	amino acid transport
M2908_RS01235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_RS01240	COG3711	transcriptional antiterminator
M2908_RS01255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M2908_RS01260	COG1473	amidohydrolase
M2908_RS01270	COG0038	chloride channel
M2908_RS01275	COG5002	protein histidine kinase activity
M2908_RS01280	COG0745	RESPONSE REGULATOR receiver
M2908_RS01285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M2908_RS01290	COG0569	domain protein
M2908_RS01290	COG0475	glutathione-regulated potassium exporter activity
M2908_RS01305	COG0284	orotidine-5'-phosphate decarboxylase activity
M2908_RS01315	COG0543	2 iron, 2 sulfur cluster binding
M2908_RS01320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M2908_RS01330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M2908_RS01335	COG0540	Belongs to the ATCase OTCase family
M2908_RS01350	COG0564	pseudouridine synthase activity
M2908_RS01355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M2908_RS01370	COG1278	Cold shock
M2908_RS01380	COG0328	RNA-DNA hybrid ribonuclease activity
M2908_RS01390	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M2908_RS01395	COG0116	Belongs to the methyltransferase superfamily
M2908_RS01410	COG4474	Belongs to the UPF0398 family
M2908_RS01415	COG3331	DNA recombination
M2908_RS01420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2908_RS01425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M2908_RS01440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_RS01445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M2908_RS01445	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M2908_RS01450	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2908_RS01450	COG3443	Belongs to the bacterial solute-binding protein 9 family
M2908_RS01465	COG0300	oxidoreductase activity
M2908_RS01470	COG1234	tRNA 3'-trailer cleavage
M2908_RS01475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M2908_RS01485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M2908_RS01500	COG1012	belongs to the aldehyde dehydrogenase family
M2908_RS01505	COG1454	alcohol dehydrogenase
M2908_RS01520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M2908_RS01525	COG3425	synthase
M2908_RS01545	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M2908_RS01560	COG1304	FMN binding
M2908_RS01575	COG0039	L-malate dehydrogenase activity
M2908_RS01585	COG4175	Glycine betaine
M2908_RS01585	COG3448	diguanylate cyclase activity
M2908_RS01640	COG1192	Involved in chromosome partitioning
M2908_RS01665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M2908_RS01665	COG0551	DNA topoisomerase type I activity
M2908_RS01675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_RS01695	COG0456	acetyltransferase
M2908_RS01710	COG0456	acetyltransferase
M2908_RS01760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M2908_RS01800	COG0149	triose-phosphate isomerase activity
M2908_RS01805	COG0126	phosphoglycerate kinase activity
M2908_RS01820	COG5582	Belongs to the UPF0302 family
M2908_RS01835	COG1160	GTP binding
M2908_RS01840	COG0539	negative regulation of cytoplasmic translation
M2908_RS01845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M2908_RS01855	COG0514	ATP-dependent DNA helicase (RecQ)
M2908_RS01870	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M2908_RS01875	COG0745	RESPONSE REGULATOR receiver
M2908_RS01880	COG1187	pseudouridine synthase activity
M2908_RS01885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M2908_RS01890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M2908_RS01895	COG4974	Belongs to the 'phage' integrase family
M2908_RS01900	COG0735	belongs to the Fur family
M2908_RS01910	COG2996	Protein conserved in bacteria
M2908_RS01920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M2908_RS01925	COG2252	PERMEase
M2908_RS01935	COG2217	Heavy metal translocating P-type atpase
M2908_RS01940	COG2608	mercury ion transmembrane transporter activity
M2908_RS01955	COG0436	Aminotransferase
M2908_RS01965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M2908_RS01965	COG1199	ATP-dependent helicase activity
M2908_RS01980	COG1187	pseudouridine synthase activity
M2908_RS01985	COG1227	inorganic diphosphatase activity
M2908_RS01990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M2908_RS01995	COG1882	Formate acetyltransferase
M2908_RS02000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M2908_RS02015	COG3684	Belongs to the aldolase LacD family
M2908_RS02030	COG1349	DNA-binding transcription factor activity
M2908_RS02045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2908_RS02045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2908_RS02050	COG1447	Phosphotransferase system cellobiose-specific component IIA
M2908_RS02055	COG0583	DNA-binding transcription factor activity
M2908_RS02065	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2908_RS02070	COG0022	dehydrogenase e1 component
M2908_RS02075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M2908_RS02080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2908_RS02085	COG3426	butyrate kinase activity
M2908_RS02090	COG0280	phosphate acetyltransferase
M2908_RS02095	COG1073	alpha beta
M2908_RS02125	COG2151	metal-sulfur cluster biosynthetic enzyme
M2908_RS02130	COG1073	alpha beta
M2908_RS02135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2908_RS02140	COG1268	BioY protein
M2908_RS02145	COG2514	catechol 2,3-dioxygenase activity
M2908_RS02150	COG0335	large ribosomal subunit rRNA binding
M2908_RS02160	COG0740	serine-type endopeptidase activity
M2908_RS02165	COG1481	regulation of sporulation
M2908_RS02170	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M2908_RS02175	COG1660	Displays ATPase and GTPase activities
M2908_RS02180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M2908_RS02185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M2908_RS02190	COG0556	nucleotide-excision repair
M2908_RS02200	COG1609	Transcriptional regulator
M2908_RS02205	COG1757	Na H antiporter
M2908_RS02215	COG2746	aminoglycoside 3-N-acetyltransferase activity
M2908_RS02230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2908_RS02235	COG3442	glutamine amidotransferase
M2908_RS02240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2908_RS02250	COG1252	NADH dehydrogenase
M2908_RS02255	COG2814	Major facilitator Superfamily
M2908_RS02265	COG3158	transport of potassium into the cell
M2908_RS02275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2908_RS02290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M2908_RS02290	COG0392	lysyltransferase activity
M2908_RS02295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M2908_RS02305	COG1486	melibiose metabolic process
M2908_RS02310	COG1428	Deoxynucleoside kinase
M2908_RS02325	COG1129	ABC transporter
M2908_RS02335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2908_RS02340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M2908_RS02345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M2908_RS02365	COG0569	domain protein
M2908_RS02370	COG2197	response regulator
M2908_RS02375	COG4585	Histidine kinase
M2908_RS02385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M2908_RS02390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M2908_RS02395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2908_RS02400	COG1126	abc transporter atp-binding protein
M2908_RS02405	COG0765	amino acid transport
M2908_RS02410	COG2205	protein histidine kinase activity
M2908_RS02415	COG0745	RESPONSE REGULATOR receiver
M2908_RS02420	COG0588	phosphoglycerate mutase activity
M2908_RS02435	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M2908_RS02445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M2908_RS02450	COG0456	acetyltransferase
M2908_RS02460	COG1214	PFAM Peptidase M22, glycoprotease
M2908_RS02465	COG1609	Transcriptional regulator
M2908_RS02470	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M2908_RS02475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M2908_RS02480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M2908_RS02485	COG0363	glucosamine-6-phosphate deaminase activity
M2908_RS02495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M2908_RS02510	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
M2908_RS02515	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
M2908_RS02520	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
M2908_RS02525	COG1527	subunit (C
M2908_RS02535	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2908_RS02540	COG1269	ATP hydrolysis coupled proton transport
M2908_RS02550	COG1966	Carbon starvation protein
M2908_RS02555	COG3279	Response regulator of the LytR AlgR family
M2908_RS02560	COG3275	phosphorelay sensor kinase activity
M2908_RS02565	COG0513	Belongs to the DEAD box helicase family
M2908_RS02575	COG1473	amidohydrolase
M2908_RS02580	COG1464	Belongs to the NlpA lipoprotein family
M2908_RS02590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2908_RS02595	COG1073	alpha beta
M2908_RS02600	COG2217	Heavy metal translocating P-type atpase
M2908_RS02605	COG0514	ATP-dependent DNA helicase (RecQ)
M2908_RS02615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M2908_RS02620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M2908_RS02640	COG2966	Psort location CytoplasmicMembrane, score
M2908_RS02645	COG0765	amino acid transport
M2908_RS02650	COG1126	abc transporter atp-binding protein
M2908_RS02660	COG0280	phosphate acetyltransferase
M2908_RS02685	COG0583	DNA-binding transcription factor activity
M2908_RS02690	COG0825	malonyl-CoA metabolic process
M2908_RS02695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M2908_RS02700	COG0439	Biotin carboxylase
M2908_RS02705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M2908_RS02715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M2908_RS02720	COG1028	Short-chain dehydrogenase reductase Sdr
M2908_RS02725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M2908_RS02735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2908_RS02740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M2908_RS02750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M2908_RS02755	COG0351	phosphomethylpyrimidine kinase
M2908_RS02765	COG0516	GMP reductase activity
M2908_RS02775	COG2226	methyltransferase
M2908_RS02780	COG0799	negative regulation of ribosome biogenesis
M2908_RS02785	COG1713	HD superfamily hydrolase involved in NAD metabolism
M2908_RS02790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M2908_RS02795	COG1534	Rna-binding protein
M2908_RS02800	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M2908_RS02805	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M2908_RS02815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M2908_RS02830	COG0415	Belongs to the DNA photolyase family
M2908_RS02840	COG0431	NADPH-dependent FMN reductase
M2908_RS02850	COG0346	lactoylglutathione lyase activity
M2908_RS02855	COG1846	Transcriptional regulator
M2908_RS02865	COG0419	ATPase involved in DNA repair
M2908_RS02870	COG0420	3'-5' exonuclease activity
M2908_RS02905	COG1473	amidohydrolase
M2908_RS02915	COG1940	carbohydrate kinase activity
M2908_RS02945	COG2972	Histidine kinase
M2908_RS02950	COG2197	response regulator
M2908_RS02955	COG4209	transmembrane transport
M2908_RS02965	COG0395	ABC-type sugar transport system, permease component
M2908_RS02990	COG2723	6-phospho-beta-galactosidase activity
M2908_RS02995	COG1263	PTS System
M2908_RS02995	COG2190	(PTS) system
M2908_RS02995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_RS03000	COG3711	transcriptional antiterminator
M2908_RS03025	COG3976	FMN-binding domain protein
M2908_RS03025	COG0431	NADPH-dependent FMN reductase
M2908_RS03025	COG1053	succinate dehydrogenase
M2908_RS03040	COG3104	oligopeptide transport
M2908_RS03045	COG0450	alkyl hydroperoxide reductase
M2908_RS03070	COG0346	lactoylglutathione lyase activity
M2908_RS03075	COG3976	FMN-binding domain protein
M2908_RS03075	COG1053	succinate dehydrogenase
M2908_RS03080	COG2972	Histidine kinase
M2908_RS03085	COG2207	Transcriptional regulator
M2908_RS03085	COG4753	response regulator
M2908_RS03105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2908_RS03125	COG0488	(ABC) transporter
M2908_RS03145	COG0149	triose-phosphate isomerase activity
M2908_RS03150	COG0205	6-phosphofructokinase activity
M2908_RS03155	COG1609	Transcriptional regulator
M2908_RS03165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M2908_RS03170	COG0191	fructose-bisphosphate aldolase activity
M2908_RS03175	COG0395	ABC-type sugar transport system, permease component
M2908_RS03180	COG1175	transmembrane transport
M2908_RS03190	COG1609	Transcriptional regulator
M2908_RS03195	COG1606	tRNA processing
M2908_RS03205	COG1691	(AIR) carboxylase
M2908_RS03220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2908_RS03225	COG0601	transmembrane transport
M2908_RS03235	COG0800	Aldolase
M2908_RS03240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2908_RS03275	COG1609	Transcriptional regulator
M2908_RS03285	COG0822	iron-sulfur transferase activity
M2908_RS03290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M2908_RS03295	COG0719	Fe-S assembly protein
M2908_RS03305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M2908_RS03320	COG1132	(ABC) transporter
M2908_RS03325	COG1132	(ABC) transporter
M2908_RS03330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M2908_RS03330	COG2207	Transcriptional regulator
M2908_RS03335	COG0482	sulfurtransferase activity
M2908_RS03345	COG1104	cysteine desulfurase activity
M2908_RS03350	COG3594	Acyltransferase
M2908_RS03355	COG1335	isochorismatase
M2908_RS03360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M2908_RS03380	COG3853	Toxic anion resistance protein (TelA)
M2908_RS03385	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2908_RS03385	COG2918	glutathione biosynthetic process
M2908_RS03390	COG0552	protein localization to endoplasmic reticulum
M2908_RS03395	COG0561	phosphatase activity
M2908_RS03400	COG1196	nuclear chromosome segregation
M2908_RS03405	COG0571	ribonuclease III activity
M2908_RS03425	COG0601	transmembrane transport
M2908_RS03430	COG4608	Belongs to the ABC transporter superfamily
M2908_RS03440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M2908_RS03445	COG0416	fatty acid biosynthetic process
M2908_RS03450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M2908_RS03465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M2908_RS03470	COG1564	THIamine pyrophosphokinase
M2908_RS03475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M2908_RS03480	COG1162	GTPase activity
M2908_RS03490	COG0785	Cytochrome C biogenesis protein
M2908_RS03495	COG2815	serine threonine protein kinase
M2908_RS03495	COG0515	serine threonine protein kinase
M2908_RS03500	COG0631	protein serine/threonine phosphatase activity
M2908_RS03505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M2908_RS03505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2908_RS03510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M2908_RS03515	COG0242	peptide deformylase activity
M2908_RS03520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M2908_RS03530	COG0194	GDP metabolic process
M2908_RS03535	COG1561	YicC-like family, N-terminal region
M2908_RS03540	COG4443	Transcriptional Coactivator p15 (PC4)
M2908_RS03555	COG0736	holo-[acyl-carrier-protein] synthase activity
M2908_RS03565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M2908_RS03570	COG1181	Belongs to the D-alanine--D-alanine ligase family
M2908_RS03580	COG3764	Sortase (surface protein transpeptidase)
M2908_RS03585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M2908_RS03590	COG1671	Belongs to the UPF0178 family
M2908_RS03595	COG0495	leucyl-tRNA aminoacylation
M2908_RS03600	COG1388	LysM domain
M2908_RS03600	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2908_RS03615	COG0671	phosphoesterase, PA-phosphatase related
M2908_RS03620	COG1242	4 iron, 4 sulfur cluster binding
M2908_RS03625	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M2908_RS03630	COG0477	Major facilitator Superfamily
M2908_RS03635	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M2908_RS03645	COG0222	ribosome binding
M2908_RS03650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M2908_RS03655	COG0081	regulation of translation
M2908_RS03660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M2908_RS03665	COG1760	l-serine dehydratase
M2908_RS03670	COG1760	l-serine dehydratase
M2908_RS03675	COG1396	sequence-specific DNA binding
M2908_RS03695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M2908_RS03700	COG3123	guanosine phosphorylase activity
M2908_RS03705	COG0250	Participates in transcription elongation, termination and antitermination
M2908_RS03715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M2908_RS03725	COG1203	CRISPR-associated helicase, Cas3
M2908_RS03755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M2908_RS03760	COG3599	regulation of cell shape
M2908_RS03765	COG2302	S4 RNA-binding domain
M2908_RS03775	COG1799	cell septum assembly
M2908_RS03780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M2908_RS03790	COG0849	cell division
M2908_RS03800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M2908_RS03805	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M2908_RS03810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2908_RS03815	COG0768	penicillin binding
M2908_RS03825	COG0275	rRNA processing
M2908_RS03830	COG2001	Belongs to the MraZ family
M2908_RS03845	COG0497	DNA recombination
M2908_RS03850	COG1438	arginine binding
M2908_RS03855	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M2908_RS03860	COG0142	geranyltranstransferase activity
M2908_RS03865	COG1722	exodeoxyribonuclease VII activity
M2908_RS03870	COG1570	exodeoxyribonuclease VII activity
M2908_RS03875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M2908_RS03880	COG1302	Protein conserved in bacteria
M2908_RS03885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M2908_RS03890	COG0006	proline dipeptidase activity
M2908_RS03895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M2908_RS03905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M2908_RS03925	COG0589	response to stress
M2908_RS03930	COG4106	trans-aconitate 2-methyltransferase activity
M2908_RS03935	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
M2908_RS03940	COG2017	converts alpha-aldose to the beta-anomer
M2908_RS03945	COG1388	LysM domain
M2908_RS03945	COG1705	Flagellar rod assembly protein muramidase FlgJ
M2908_RS03950	COG0254	rRNA binding
M2908_RS03955	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M2908_RS03960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M2908_RS03965	COG1686	Belongs to the peptidase S11 family
M2908_RS03975	COG1132	(ABC) transporter
M2908_RS03990	COG1114	Component of the transport system for branched-chain amino acids
M2908_RS03995	COG2608	mercury ion transmembrane transporter activity
M2908_RS04010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M2908_RS04030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_RS04040	COG2226	methyltransferase
M2908_RS04055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M2908_RS04060	COG1597	lipid kinase activity
M2908_RS04065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2908_RS04070	COG0154	amidase activity
M2908_RS04075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M2908_RS04080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M2908_RS04085	COG0210	DNA helicase
M2908_RS04090	COG1668	transmembrane transport
M2908_RS04095	COG4152	abc transporter atp-binding protein
M2908_RS04105	COG0322	excinuclease ABC activity
M2908_RS04185	COG0735	belongs to the Fur family
M2908_RS04190	COG2176	DNA-directed DNA polymerase activity
M2908_RS04195	COG0442	prolyl-tRNA aminoacylation
M2908_RS04200	COG0750	zinc metalloprotease
M2908_RS04205	COG4589	Belongs to the CDS family
M2908_RS04210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M2908_RS04215	COG0038	chloride channel
M2908_RS04220	COG0233	cytoplasmic translational termination
M2908_RS04225	COG0528	UMP kinase activity
M2908_RS04230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M2908_RS04235	COG0052	Belongs to the universal ribosomal protein uS2 family
M2908_RS04240	COG2813	Specifically methylates the guanine in position
M2908_RS04250	COG1607	acyl-coa hydrolase
M2908_RS04255	COG1072	(Pantothenic acid kinase))
M2908_RS04260	COG0519	Catalyzes the synthesis of GMP from XMP
M2908_RS04260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M2908_RS04270	COG0582	viral genome integration into host DNA
M2908_RS04330	COG0531	amino acid
M2908_RS04335	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M2908_RS04340	COG0508	dehydrogenase complex catalyzes the overall conversion of
M2908_RS04345	COG0022	dehydrogenase e1 component
M2908_RS04350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M2908_RS04355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2908_RS04360	COG3284	Transcriptional regulator
M2908_RS04380	COG0726	polysaccharide deacetylase
M2908_RS04390	COG1196	nuclear chromosome segregation
M2908_RS04390	COG0741	lytic transglycosylase activity
M2908_RS04390	COG0739	heme binding
M2908_RS04395	COG2723	6-phospho-beta-galactosidase activity
M2908_RS04400	COG2188	Transcriptional regulator
M2908_RS04410	COG0789	Transcriptional regulator
M2908_RS04435	COG1263	PTS System
M2908_RS04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_RS04440	COG0366	Alpha amylase catalytic
M2908_RS04445	COG2188	Transcriptional regulator
M2908_RS04450	COG1959	2 iron, 2 sulfur cluster binding
M2908_RS04465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_RS04470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M2908_RS04485	COG1446	asparaginase
M2908_RS04490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2908_RS04495	COG2188	Transcriptional regulator
M2908_RS04500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2908_RS04505	COG4466	Protein conserved in bacteria
M2908_RS04515	COG1164	Oligoendopeptidase f
M2908_RS04540	COG1012	belongs to the aldehyde dehydrogenase family
M2908_RS04540	COG1454	alcohol dehydrogenase
M2908_RS04550	COG1862	Preprotein translocase
M2908_RS04555	COG0343	queuine tRNA-ribosyltransferase activity
M2908_RS04560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M2908_RS04565	COG2255	four-way junction helicase activity
M2908_RS04570	COG0632	four-way junction helicase activity
M2908_RS04580	COG0673	inositol 2-dehydrogenase activity
M2908_RS04585	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M2908_RS04590	COG1082	Xylose isomerase domain protein TIM barrel
M2908_RS04595	COG0673	inositol 2-dehydrogenase activity
M2908_RS04600	COG3962	Belongs to the TPP enzyme family
M2908_RS04605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2908_RS04610	COG3718	enzyme involved in inositol metabolism
M2908_RS04615	COG1012	belongs to the aldehyde dehydrogenase family
M2908_RS04620	COG1349	DNA-binding transcription factor activity
M2908_RS04625	COG1942	4-Oxalocrotonate Tautomerase
M2908_RS04645	COG4607	ABC-type enterochelin transport system periplasmic component
M2908_RS04650	COG4604	ABC transporter, ATP-binding protein
M2908_RS04655	COG4605	iron ion homeostasis
M2908_RS04660	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M2908_RS04665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M2908_RS04670	COG0827	DNA restriction-modification system
M2908_RS04675	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M2908_RS04680	COG1803	Methylglyoxal synthase
M2908_RS04685	COG3842	ATPase activity
M2908_RS04690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M2908_RS04695	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M2908_RS04700	COG0084	hydrolase, TatD family'
M2908_RS04705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2908_RS04705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2908_RS04710	COG0584	glycerophosphoryl diester phosphodiesterase
M2908_RS04715	COG0574	Belongs to the PEP-utilizing enzyme family
M2908_RS04715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M2908_RS04725	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M2908_RS04735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M2908_RS04740	COG0110	maltose O-acetyltransferase activity
M2908_RS04760	COG0436	Aminotransferase
M2908_RS04765	COG1174	glycine betaine transport
M2908_RS04770	COG1732	Glycine betaine
M2908_RS04800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M2908_RS04805	COG0673	inositol 2-dehydrogenase activity
M2908_RS04810	COG1082	Xylose isomerase domain protein TIM barrel
M2908_RS04820	COG0673	inositol 2-dehydrogenase activity
M2908_RS04825	COG2207	Transcriptional regulator
M2908_RS04830	COG1968	undecaprenyl-diphosphatase activity
M2908_RS04835	COG2217	Heavy metal translocating P-type atpase
M2908_RS04840	COG1392	Phosphate transport regulator
M2908_RS04845	COG0306	phosphate transporter
M2908_RS04850	COG0268	Binds directly to 16S ribosomal RNA
M2908_RS04855	COG1466	dna polymerase III delta subunit
M2908_RS04860	COG0658	competence protein
M2908_RS04860	COG2333	competence protein COMEC
M2908_RS04865	COG2131	deaminase
M2908_RS04870	COG1555	photosystem II stabilization
M2908_RS04870	COG1596	polysaccharide export
M2908_RS04880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M2908_RS04885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M2908_RS04895	COG4717	serine-type aminopeptidase activity
M2908_RS04905	COG0765	amino acid transport
M2908_RS04915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M2908_RS04920	COG4475	Protein of unknown function (DUF436)
M2908_RS04925	COG1132	(ABC) transporter
M2908_RS04930	COG1132	(ABC) transporter
M2908_RS04970	COG4467	Involved in initiation control of chromosome replication
M2908_RS04975	COG1774	PSP1 C-terminal conserved region
M2908_RS04980	COG0470	DNA polymerase III
M2908_RS04985	COG3870	Protein conserved in bacteria
M2908_RS04990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M2908_RS04995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M2908_RS05000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M2908_RS05005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M2908_RS05030	COG0590	tRNA wobble adenosine to inosine editing
M2908_RS05035	COG2508	Transcriptional regulator
M2908_RS05045	COG2738	Putative neutral zinc metallopeptidase
M2908_RS05050	COG2824	Alkylphosphonate utilization operon protein PhnA
M2908_RS05070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M2908_RS05080	COG0628	permease
M2908_RS05090	COG2706	6-phosphogluconolactonase activity
M2908_RS05105	COG0191	fructose-bisphosphate aldolase activity
M2908_RS05130	COG1217	gtp-binding protein TYPA
M2908_RS05135	COG0483	inositol monophosphate 1-phosphatase activity
M2908_RS05140	COG4476	Belongs to the UPF0223 family
M2908_RS05145	COG3850	Histidine kinase
M2908_RS05145	COG5002	protein histidine kinase activity
M2908_RS05150	COG0745	RESPONSE REGULATOR receiver
M2908_RS05155	COG0561	phosphatase activity
M2908_RS05165	COG1597	lipid kinase activity
M2908_RS05170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M2908_RS05175	COG0517	IMP dehydrogenase activity
M2908_RS05180	COG1346	cytolysis
M2908_RS05195	COG1418	mRNA catabolic process
M2908_RS05215	COG0424	maF-like protein
M2908_RS05225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M2908_RS05235	COG1692	metallophosphoesterase
M2908_RS05240	COG1349	DNA-binding transcription factor activity
M2908_RS05245	COG1105	Belongs to the carbohydrate kinase PfkB family
M2908_RS05250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M2908_RS05250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_RS05250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M2908_RS05265	COG1378	Sugar-specific transcriptional regulator TrmB
M2908_RS05275	COG2094	Belongs to the DNA glycosylase MPG family
M2908_RS05280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M2908_RS05285	COG1054	Belongs to the UPF0176 family
M2908_RS05315	COG0383	alpha-mannosidase activity
M2908_RS05320	COG1979	alcohol dehydrogenase
M2908_RS05330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M2908_RS05335	COG0156	8-amino-7-oxononanoate synthase activity
M2908_RS05365	COG1621	beta-fructofuranosidase activity
M2908_RS05375	COG1609	Transcriptional regulator
M2908_RS05380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M2908_RS05385	COG1263	PTS System
M2908_RS05385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_RS05385	COG2190	(PTS) system
M2908_RS05390	COG1263	PTS System
M2908_RS05390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_RS05395	COG2233	PERMEase
M2908_RS05400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_RS05405	COG1733	regulation of RNA biosynthetic process
M2908_RS05410	COG2910	NAD(P)H-binding
M2908_RS05420	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2908_RS05440	COG3732	PTS system glucitol sorbitol-specific
M2908_RS05445	COG3730	PTS system glucitol sorbitol-specific
M2908_RS05455	COG3711	transcriptional antiterminator
M2908_RS05455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_RS05465	COG0583	DNA-binding transcription factor activity
M2908_RS05475	COG0390	transport system, permease component
M2908_RS05480	COG4619	ABC transporter
M2908_RS05490	COG0463	Glycosyl transferase, family 2
M2908_RS05495	COG2246	polysaccharide biosynthetic process
M2908_RS05500	COG0737	Belongs to the 5'-nucleotidase family
M2908_RS05510	COG0402	S-adenosylhomocysteine deaminase activity
M2908_RS05530	COG1122	ATPase activity
M2908_RS05535	COG4720	Psort location CytoplasmicMembrane, score
M2908_RS05570	COG3716	PTS system mannose fructose sorbose family IID component
M2908_RS05575	COG3715	PTS system
M2908_RS05585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_RS05585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_RS05590	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M2908_RS05590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M2908_RS05595	COG2814	Major facilitator Superfamily
M2908_RS05600	COG1285	pathogenesis
M2908_RS05610	COG2723	6-phospho-beta-galactosidase activity
M2908_RS05615	COG3711	transcriptional antiterminator
M2908_RS05620	COG1263	PTS System
M2908_RS05620	COG2190	(PTS) system
M2908_RS05620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_RS05630	COG0590	tRNA wobble adenosine to inosine editing
M2908_RS05640	COG0625	glutathione transferase activity
M2908_RS05650	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M2908_RS05655	COG3457	Alanine racemase
M2908_RS05665	COG2188	Transcriptional regulator
M2908_RS05670	COG0626	cystathionine gamma-synthase activity
M2908_RS05695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M2908_RS05700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M2908_RS05715	COG5002	protein histidine kinase activity
M2908_RS05720	COG0745	RESPONSE REGULATOR receiver
M2908_RS05725	COG3973	AAA domain
M2908_RS05730	COG1737	Transcriptional regulator
M2908_RS05735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2908_RS05740	COG1263	PTS System
M2908_RS05740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_RS05745	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M2908_RS05760	COG1278	Cold shock
M2908_RS05780	COG1418	mRNA catabolic process
M2908_RS05785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M2908_RS05790	COG1058	Belongs to the CinA family
M2908_RS05790	COG1546	Belongs to the CinA family
M2908_RS05795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M2908_RS05800	COG1426	Protein conserved in bacteria
M2908_RS05810	COG0612	Peptidase, M16
M2908_RS05815	COG0612	Peptidase, M16
M2908_RS05820	COG1970	mechanosensitive ion channel activity
M2908_RS05825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M2908_RS05835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M2908_RS05840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M2908_RS05845	COG1121	(ABC) transporter
M2908_RS05850	COG1121	(ABC) transporter
M2908_RS05855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M2908_RS05860	COG0803	Belongs to the bacterial solute-binding protein 9 family
M2908_RS05870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_RS05870	COG1263	PTS System
M2908_RS05870	COG2190	(PTS) system
M2908_RS05875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M2908_RS05880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M2908_RS05885	COG1177	transmembrane transport
M2908_RS05890	COG1176	ABC-type spermidine putrescine transport system, permease component I
M2908_RS05895	COG3842	ATPase activity
M2908_RS05905	COG0604	alcohol dehydrogenase
M2908_RS05910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M2908_RS05915	COG0708	Exodeoxyribonuclease III
M2908_RS05930	COG0737	Belongs to the 5'-nucleotidase family
M2908_RS05935	COG0802	atpase or kinase
M2908_RS05940	COG0280	phosphate acetyltransferase
M2908_RS05945	COG0561	phosphatase activity
M2908_RS05960	COG0142	geranyltranstransferase activity
M2908_RS05970	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M2908_RS05975	COG4988	ABC transporter
M2908_RS05980	COG1294	oxidase, subunit
M2908_RS05985	COG1271	oxidase subunit
M2908_RS05990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M2908_RS06000	COG0826	peptidase U32
M2908_RS06010	COG0542	response to heat
M2908_RS06015	COG4463	regulation of RNA biosynthetic process
M2908_RS06075	COG0406	alpha-ribazole phosphatase activity
M2908_RS06090	COG1686	Belongs to the peptidase S11 family
M2908_RS06095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M2908_RS06150	COG0516	GMP reductase activity
M2908_RS06150	COG0517	IMP dehydrogenase activity
M2908_RS06160	COG0012	GTP binding
M2908_RS06165	COG4481	Protein conserved in bacteria
M2908_RS06170	COG1475	DNA binding
M2908_RS06175	COG1192	Involved in chromosome partitioning
M2908_RS06180	COG0357	Ribosomal RNA small subunit methyltransferase G
M2908_RS06195	COG0445	tRNA wobble uridine modification
M2908_RS06200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M2908_RS06210	COG0706	membrane insertase activity
M2908_RS06220	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M2908_RS06225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M2908_RS06230	COG0592	DNA-directed DNA polymerase activity
M2908_RS06235	COG2188	Transcriptional regulator
M2908_RS06240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M2908_RS06250	COG3715	PTS system
M2908_RS06255	COG3716	PTS system mannose fructose sorbose family IID component
M2908_RS06270	COG5492	domain, Protein
M2908_RS06275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2908_RS06280	COG0800	Aldolase
M2908_RS06285	COG1414	Transcriptional regulator
M2908_RS06290	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M2908_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
M2908_RS06310	COG2501	S4 domain
M2908_RS06315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M2908_RS06320	COG0187	DNA topoisomerase II activity
M2908_RS06330	COG0360	Binds together with S18 to 16S ribosomal RNA
M2908_RS06340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M2908_RS06345	COG0359	binds to the 23S rRNA
M2908_RS06350	COG0305	Participates in initiation and elongation during chromosome replication
M2908_RS06360	COG0488	(ABC) transporter
M2908_RS06380	COG4939	FMN-binding domain protein
M2908_RS06400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M2908_RS06405	COG4120	Belongs to the binding-protein-dependent transport system permease family
M2908_RS06420	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M2908_RS06425	COG0295	cytidine deaminase activity
M2908_RS06430	COG1744	ABC transporter substrate-binding protein PnrA-like
M2908_RS06435	COG3845	ABC transporter
M2908_RS06440	COG4603	Belongs to the binding-protein-dependent transport system permease family
M2908_RS06445	COG1079	Belongs to the binding-protein-dependent transport system permease family
M2908_RS06450	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M2908_RS06455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M2908_RS06460	COG0813	purine-nucleoside phosphorylase activity
M2908_RS06465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M2908_RS06470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M2908_RS06475	COG0049	tRNA binding
M2908_RS06480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M2908_RS06485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M2908_RS06495	COG0051	transcription antitermination factor activity, RNA binding
M2908_RS06500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M2908_RS06505	COG0088	Forms part of the polypeptide exit tunnel
M2908_RS06510	COG0089	rRNA binding
M2908_RS06515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M2908_RS06525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M2908_RS06530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M2908_RS06535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M2908_RS06540	COG0255	Belongs to the universal ribosomal protein uL29 family
M2908_RS06545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M2908_RS06550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M2908_RS06555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M2908_RS06560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M2908_RS06565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M2908_RS06570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M2908_RS06575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M2908_RS06585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M2908_RS06590	COG1841	ribosomal large subunit assembly
M2908_RS06595	COG0200	Binds to the 23S rRNA
M2908_RS06600	COG0201	protein transport
M2908_RS06605	COG0563	adenylate kinase activity
M2908_RS06615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M2908_RS06620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M2908_RS06625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M2908_RS06630	COG0202	RNA polymerase activity
M2908_RS06635	COG0203	ribosomal protein L17
M2908_RS06640	COG1122	ATPase activity
M2908_RS06645	COG1122	ATPase activity
M2908_RS06655	COG0101	tRNA pseudouridine synthase activity
M2908_RS06660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M2908_RS06665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M2908_RS06680	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M2908_RS06700	COG1401	restriction endodeoxyribonuclease activity
M2908_RS06785	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M2908_RS06790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M2908_RS06810	COG3973	AAA domain
M2908_RS06820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2908_RS06835	COG2003	Belongs to the UPF0758 family
M2908_RS06845	COG0477	Major facilitator Superfamily
M2908_RS06855	COG0488	(ABC) transporter
M2908_RS06870	COG3291	Pkd domain containing protein
M2908_RS06870	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M2908_RS06885	COG0456	acetyltransferase
M2908_RS06890	COG2723	6-phospho-beta-galactosidase activity
M2908_RS06920	COG4209	transmembrane transport
M2908_RS06925	COG0395	ABC-type sugar transport system, permease component
M2908_RS06940	COG1482	cell wall glycoprotein biosynthetic process
M2908_RS06955	COG2076	Multidrug Resistance protein
M2908_RS06960	COG2076	Multidrug Resistance protein
M2908_RS06965	COG3859	Proton-coupled thiamine transporter YuaJ
M2908_RS06980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2908_RS06995	COG3579	cysteine-type endopeptidase activity
M2908_RS07015	COG3639	organic phosphonate transmembrane transporter activity
M2908_RS07020	COG0737	Belongs to the 5'-nucleotidase family
M2908_RS07025	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2908_RS07030	COG0589	response to stress
M2908_RS07045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M2908_RS07055	COG2264	protein methyltransferase activity
M2908_RS07060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M2908_RS07085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M2908_RS07090	COG1490	D-aminoacyl-tRNA deacylase activity
M2908_RS07095	COG0860	N-Acetylmuramoyl-L-alanine amidase
M2908_RS07095	COG3103	Sh3 type 3 domain protein
M2908_RS07095	COG4991	sh3 domain protein
M2908_RS07100	COG0124	histidyl-tRNA synthetase
M2908_RS07105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M2908_RS07110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M2908_RS07115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2908_RS07130	COG1605	Chorismate mutase
M2908_RS07130	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M2908_RS07135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M2908_RS07140	COG4493	Belongs to the UPF0637 family
M2908_RS07150	COG1363	Peptidase, m42
M2908_RS07155	COG2244	polysaccharide biosynthetic process
M2908_RS07160	COG1187	pseudouridine synthase activity
M2908_RS07170	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2908_RS07175	COG1937	Protein conserved in bacteria
M2908_RS07180	COG0756	dUTP diphosphatase activity
M2908_RS07190	COG4956	integral membrane protein (PIN domain superfamily)
M2908_RS07195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M2908_RS07200	COG1045	serine acetyltransferase
M2908_RS07205	COG0215	cysteine-tRNA ligase activity
M2908_RS07210	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M2908_RS07220	COG3688	RNA-binding protein containing a PIN domain
M2908_RS07230	COG0217	transcriptional regulatory protein
M2908_RS07235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M2908_RS07240	COG1459	type II secretion system
M2908_RS07300	COG1484	DNA-dependent DNA replication
M2908_RS07390	COG2369	cell adhesion
M2908_RS07505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M2908_RS07510	COG0572	uridine kinase
M2908_RS07540	COG2249	NAD(P)H dehydrogenase (quinone) activity
M2908_RS07550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M2908_RS07555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M2908_RS07560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M2908_RS07565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M2908_RS07570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M2908_RS07575	COG1328	CTP reductase activity
M2908_RS07585	COG1363	Peptidase, m42
M2908_RS07590	COG1234	tRNA 3'-trailer cleavage
M2908_RS07595	COG0095	Lipoate-protein ligase
M2908_RS07600	COG0180	Tryptophanyl-tRNA synthetase
M2908_RS07605	COG1393	Belongs to the ArsC family
M2908_RS07610	COG4862	establishment of competence for transformation
M2908_RS07615	COG4684	Psort location CytoplasmicMembrane, score
M2908_RS07620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M2908_RS07625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M2908_RS07635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2908_RS07640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M2908_RS07645	COG1780	Probably involved in ribonucleotide reductase function
M2908_RS07650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M2908_RS07660	COG0193	aminoacyl-tRNA hydrolase activity
M2908_RS07665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M2908_RS07670	COG2244	polysaccharide biosynthetic process
M2908_RS07675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M2908_RS07685	COG1098	S1 RNA binding domain
M2908_RS07690	COG0037	tRNA processing
M2908_RS07695	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M2908_RS07700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M2908_RS07705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M2908_RS07710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M2908_RS07715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M2908_RS07860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2908_RS07880	COG0577	efflux transmembrane transporter activity
M2908_RS07885	COG1136	(ABC) transporter
M2908_RS07890	COG0183	Belongs to the thiolase family
M2908_RS07895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M2908_RS07900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M2908_RS07910	COG0450	alkyl hydroperoxide reductase
M2908_RS07915	COG3634	alkyl hydroperoxide reductase activity
M2908_RS07920	COG2390	Transcriptional regulator
M2908_RS07935	COG0494	nUDIX hydrolase
M2908_RS07945	COG1309	transcriptional regulator
M2908_RS07950	COG2376	Dihydroxyacetone kinase
M2908_RS07960	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
M2908_RS07965	COG1461	Dihydroxyacetone kinase
M2908_RS07970	COG2376	Dihydroxyacetone kinase
M2908_RS07975	COG1288	antiporter activity
M2908_RS07980	COG1959	2 iron, 2 sulfur cluster binding
M2908_RS08005	COG2827	Endonuclease containing a URI domain
M2908_RS08010	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M2908_RS08015	COG0204	Acyl-transferase
M2908_RS08020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M2908_RS08025	COG1132	(ABC) transporter
M2908_RS08035	COG2814	Major facilitator Superfamily
M2908_RS08040	COG4109	DRTGG domain
M2908_RS08045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M2908_RS08055	COG1609	Transcriptional regulator
M2908_RS08060	COG0488	(ABC) transporter
M2908_RS08065	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M2908_RS08070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M2908_RS08075	COG0459	protein refolding
M2908_RS08080	COG2972	Histidine kinase
M2908_RS08095	COG3842	ATPase activity
M2908_RS08105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M2908_RS08110	COG0656	L-ascorbic acid biosynthetic process
M2908_RS08115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_RS08115	COG1263	PTS System
M2908_RS08120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M2908_RS08125	COG0281	malic enzyme
M2908_RS08130	COG0114	fumarate hydratase activity
M2908_RS08135	COG1737	Transcriptional regulator
M2908_RS08140	COG0737	Belongs to the 5'-nucleotidase family
M2908_RS08150	COG2207	Transcriptional regulator
M2908_RS08160	COG0242	peptide deformylase activity
M2908_RS08165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M2908_RS08170	COG1185	polyribonucleotide nucleotidyltransferase activity
M2908_RS08175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M2908_RS08180	COG0768	penicillin binding
M2908_RS08185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M2908_RS08195	COG0457	Tetratricopeptide repeat
M2908_RS08195	COG0705	Rhomboid family
M2908_RS08200	COG1940	carbohydrate kinase activity
M2908_RS08205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M2908_RS08215	COG5503	Protein of unknown function (DUF1447)
M2908_RS08225	COG1132	(ABC) transporter
M2908_RS08235	COG0673	inositol 2-dehydrogenase activity
M2908_RS08245	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M2908_RS08245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M2908_RS08250	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2908_RS08260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M2908_RS08285	COG2309	aminopeptidase activity
M2908_RS08295	COG0716	FMN binding
M2908_RS08300	COG0024	Methionine aminopeptidase
M2908_RS08305	COG1295	ribonuclease BN
M2908_RS08310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M2908_RS08315	COG1316	TRANSCRIPTIONal
M2908_RS08320	COG1134	teichoic acid transport
M2908_RS08325	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2908_RS08330	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M2908_RS08335	COG1682	transport, permease protein
M2908_RS08340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2908_RS08345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M2908_RS08350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2908_RS08350	COG0463	Glycosyl transferase, family 2
M2908_RS08355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M2908_RS08360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M2908_RS08360	COG0463	Glycosyl transferase, family 2
M2908_RS08390	COG3944	biosynthesis protein
M2908_RS08395	COG0489	protein tyrosine kinase activity
M2908_RS08400	COG4464	protein tyrosine phosphatase activity
M2908_RS08410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M2908_RS08425	COG1086	Polysaccharide biosynthesis protein
M2908_RS08455	COG1442	glycosyl transferase family 8
M2908_RS08470	COG0686	Belongs to the AlaDH PNT family
M2908_RS08480	COG1316	TRANSCRIPTIONal
M2908_RS08485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M2908_RS08495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M2908_RS08525	COG2137	regulation of response to DNA damage stimulus
M2908_RS08530	COG1194	a g-specific adenine glycosylase
M2908_RS08535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M2908_RS08535	COG0392	lysyltransferase activity
M2908_RS08555	COG3764	Sortase (surface protein transpeptidase)
M2908_RS08575	COG3557	Belongs to the UPF0374 family
M2908_RS08595	COG0628	permease
M2908_RS08600	COG1253	flavin adenine dinucleotide binding
M2908_RS08615	COG1609	Transcriptional regulator
M2908_RS08620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M2908_RS08630	COG1129	ABC transporter
M2908_RS08635	COG1172	Belongs to the binding-protein-dependent transport system permease family
M2908_RS08640	COG1879	ABC-type sugar transport system periplasmic component
M2908_RS08645	COG1278	Cold shock
M2908_RS08655	COG1136	(ABC) transporter
M2908_RS08655	COG0577	efflux transmembrane transporter activity
M2908_RS08660	COG1136	(ABC) transporter
M2908_RS08660	COG0577	efflux transmembrane transporter activity
M2908_RS08665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M2908_RS08670	COG0640	Transcriptional regulator
M2908_RS08675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M2908_RS08685	COG4116	CYTH
M2908_RS08690	COG2357	RelA SpoT domain protein
M2908_RS08695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M2908_RS08700	COG0564	pseudouridine synthase activity
M2908_RS08705	COG2239	Acts as a magnesium transporter
M2908_RS08710	COG3142	Participates in the control of copper homeostasis
M2908_RS08715	COG0500	methyltransferase
M2908_RS08725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M2908_RS08730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M2908_RS08735	COG1368	sulfuric ester hydrolase activity
M2908_RS08745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M2908_RS08750	COG0765	amino acid transport
M2908_RS08760	COG1368	sulfuric ester hydrolase activity
M2908_RS08765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M2908_RS08775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M2908_RS08780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M2908_RS08800	COG2081	HI0933 family
M2908_RS08805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M2908_RS08810	COG0166	Belongs to the GPI family
M2908_RS08825	COG1801	Protein of unknown function DUF72
M2908_RS08830	COG0561	phosphatase activity
M2908_RS08835	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M2908_RS08840	COG1104	cysteine desulfurase activity
M2908_RS08850	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M2908_RS08855	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M2908_RS08860	COG0525	valine-tRNA ligase activity
M2908_RS08865	COG0285	dihydrofolate synthase activity
M2908_RS08870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M2908_RS08875	COG2003	Belongs to the UPF0758 family
M2908_RS08880	COG1278	Cold shock
M2908_RS08890	COG0584	glycerophosphoryl diester phosphodiesterase
M2908_RS08895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M2908_RS08900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M2908_RS08905	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M2908_RS08915	COG0542	response to heat
M2908_RS08925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_RS08930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M2908_RS08935	COG0438	transferase activity, transferring glycosyl groups
M2908_RS08940	COG0438	transferase activity, transferring glycosyl groups
M2908_RS08950	COG2084	Dehydrogenase
M2908_RS08955	COG2188	Transcriptional regulator
M2908_RS08960	COG2222	sugar isomerase
M2908_RS08965	COG3684	Belongs to the aldolase LacD family
M2908_RS08970	COG1105	Belongs to the carbohydrate kinase PfkB family
M2908_RS08975	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M2908_RS08985	COG3716	PTS system mannose fructose sorbose family IID component
M2908_RS08990	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M2908_RS09000	COG4703	Protein of unknown function (DUF1797)
M2908_RS09010	COG1714	RDD family
M2908_RS09020	COG0544	peptidyl-prolyl cis-trans isomerase activity
M2908_RS09025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M2908_RS09035	COG0351	phosphomethylpyrimidine kinase
M2908_RS09040	COG0352	thiamine-phosphate diphosphorylase activity
M2908_RS09050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M2908_RS09050	COG1116	anion transmembrane transporter activity
M2908_RS09055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2908_RS09060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M2908_RS09065	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M2908_RS09075	COG2011	ABC-type metal ion transport system permease component
M2908_RS09080	COG1464	Belongs to the NlpA lipoprotein family
M2908_RS09085	COG2116	formate transmembrane transporter activity
M2908_RS09145	COG0791	NLP P60 protein
M2908_RS09145	COG0741	lytic transglycosylase activity
M2908_RS09175	COG2946	Replication initiation factor
M2908_RS09185	COG1674	ftsk spoiiie
M2908_RS09200	COG4838	Belongs to the UPF0358 family
M2908_RS09205	COG0772	Belongs to the SEDS family
M2908_RS09210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M2908_RS09225	COG4471	UPF0298 protein
M2908_RS09230	COG0742	ribosomal rna small subunit methyltransferase
M2908_RS09235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M2908_RS09240	COG3480	Lon protease (S16) C-terminal proteolytic domain
M2908_RS09245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M2908_RS09250	COG1597	lipid kinase activity
M2908_RS09255	COG0583	DNA-binding transcription factor activity
M2908_RS09260	COG2391	methyltransferase activity
M2908_RS09265	COG0446	pyridine nucleotide-disulphide oxidoreductase
M2908_RS09270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M2908_RS09275	COG4521	taurine ABC transporter
M2908_RS09280	COG1116	anion transmembrane transporter activity
M2908_RS09290	COG4708	membrane
M2908_RS09295	COG0018	arginyl-trna synthetase
M2908_RS09300	COG1438	arginine binding
M2908_RS09310	COG0564	pseudouridine synthase activity
M2908_RS09315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M2908_RS09320	COG3679	Belongs to the UPF0342 family
M2908_RS09325	COG3481	metal-dependent phosphohydrolase, HD sub domain
M2908_RS09330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M2908_RS09340	COG0537	adenosine 5'-monophosphoramidase activity
M2908_RS09345	COG1131	(ABC) transporter
M2908_RS09355	COG0510	thiamine kinase activity
M2908_RS09360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M2908_RS09375	COG1486	melibiose metabolic process
M2908_RS09385	COG1363	Peptidase, m42
M2908_RS09390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M2908_RS09395	COG0589	response to stress
M2908_RS09400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M2908_RS09405	COG4472	Bacterial protein of unknown function (DUF965)
M2908_RS09415	COG3906	Belongs to the UPF0473 family
M2908_RS09430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M2908_RS09440	COG5294	Protein conserved in bacteria
M2908_RS09445	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M2908_RS09460	COG1193	negative regulation of DNA recombination
M2908_RS09465	COG3118	belongs to the thioredoxin family
M2908_RS09485	COG0601	transmembrane transport
M2908_RS09490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M2908_RS09495	COG0444	Belongs to the ABC transporter superfamily
M2908_RS09500	COG4608	Belongs to the ABC transporter superfamily
M2908_RS09505	COG4166	transmembrane transport
M2908_RS09520	COG2365	Tyrosine phosphatase family
M2908_RS09530	COG4470	Protein conserved in bacteria
M2908_RS09535	COG0647	UMP catabolic process
M2908_RS09545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M2908_RS09550	COG0492	ferredoxin-NADP+ reductase activity
M2908_RS09560	COG1098	S1 RNA binding domain
M2908_RS09605	COG2261	transglycosylase associated protein
M2908_RS09625	COG0709	Synthesizes selenophosphate from selenide and ATP
M2908_RS09645	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M2908_RS09655	COG0557	exoribonuclease II activity
M2908_RS09660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M2908_RS09665	COG0356	it plays a direct role in the translocation of protons across the membrane
M2908_RS09670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2908_RS09675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M2908_RS09680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M2908_RS09685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M2908_RS09690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M2908_RS09695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M2908_RS09700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M2908_RS09710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M2908_RS09720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M2908_RS09755	COG0517	IMP dehydrogenase activity
M2908_RS09785	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M2908_RS09790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M2908_RS09795	COG0546	phosphoglycolate phosphatase activity
M2908_RS09800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M2908_RS09810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M2908_RS09815	COG4224	UPF0291 protein
M2908_RS09825	COG0681	Belongs to the peptidase S26 family
M2908_RS09830	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M2908_RS09835	COG1074	ATP-dependent DNA helicase activity
M2908_RS09840	COG2188	Transcriptional regulator
M2908_RS09845	COG1739	Uncharacterized protein family UPF0029
M2908_RS09855	COG2267	carboxylic ester hydrolase activity
M2908_RS09860	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M2908_RS09875	COG0653	protein targeting
M2908_RS09885	COG2884	Cell division ATP-binding protein ftsE
M2908_RS09890	COG2177	Part of the ABC transporter FtsEX involved in
M2908_RS09895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M2908_RS09900	COG0573	inorganic phosphate transmembrane transporter activity
M2908_RS09905	COG0581	inorganic phosphate transmembrane transporter activity
M2908_RS09910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M2908_RS09915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M2908_RS09970	COG1950	PFAM Membrane protein of
M2908_RS09975	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M2908_RS09990	COG4120	Belongs to the binding-protein-dependent transport system permease family
M2908_RS09995	COG1122	ATPase activity
M2908_RS10000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M2908_RS10005	COG0735	belongs to the Fur family
M2908_RS10015	COG1610	YqeY-like protein
M2908_RS10040	COG0095	Lipoate-protein ligase
M2908_RS10050	COG3343	RNA polymerase activity
M2908_RS10080	COG2268	Band 7 protein