locus-tag	class	description
E4Z98_RS00050	COG0359	binds to the 23S rRNA
E4Z98_RS00055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E4Z98_RS00060	COG0629	single-stranded DNA binding
E4Z98_RS00065	COG0360	Binds together with S18 to 16S ribosomal RNA
E4Z98_RS00080	COG0187	DNA topoisomerase II activity
E4Z98_RS00085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4Z98_RS00090	COG2501	S4 domain
E4Z98_RS00095	COG0592	DNA-directed DNA polymerase activity
E4Z98_RS00100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4Z98_RS00105	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4Z98_RS00110	COG0594	ribonuclease P activity
E4Z98_RS00115	COG0706	membrane insertase activity
E4Z98_RS00125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E4Z98_RS00130	COG0445	tRNA wobble uridine modification
E4Z98_RS00135	COG0586	Pfam SNARE associated Golgi protein
E4Z98_RS00140	COG0357	Ribosomal RNA small subunit methyltransferase G
E4Z98_RS00145	COG1192	Involved in chromosome partitioning
E4Z98_RS00150	COG1475	DNA binding
E4Z98_RS00155	COG4481	Protein conserved in bacteria
E4Z98_RS00160	COG0012	GTP binding
E4Z98_RS00170	COG0516	GMP reductase activity
E4Z98_RS00170	COG0517	IMP dehydrogenase activity
E4Z98_RS00175	COG0686	Belongs to the AlaDH PNT family
E4Z98_RS00180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4Z98_RS00185	COG1686	Belongs to the peptidase S11 family
E4Z98_RS00265	COG1285	pathogenesis
E4Z98_RS00275	COG3584	3D domain protein
E4Z98_RS00275	COG3583	domain protein
E4Z98_RS00295	COG3973	AAA domain
E4Z98_RS00300	COG0745	RESPONSE REGULATOR receiver
E4Z98_RS00305	COG5002	protein histidine kinase activity
E4Z98_RS00325	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E4Z98_RS00340	COG1363	Peptidase, m42
E4Z98_RS00345	COG2244	polysaccharide biosynthetic process
E4Z98_RS00350	COG1187	pseudouridine synthase activity
E4Z98_RS00355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4Z98_RS00360	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4Z98_RS00365	COG1937	Protein conserved in bacteria
E4Z98_RS00380	COG0384	phenazine biosynthesis protein PhzF
E4Z98_RS00385	COG0756	dUTP diphosphatase activity
E4Z98_RS00395	COG4956	integral membrane protein (PIN domain superfamily)
E4Z98_RS00400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4Z98_RS00405	COG1045	serine acetyltransferase
E4Z98_RS00410	COG0215	cysteine-tRNA ligase activity
E4Z98_RS00415	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E4Z98_RS00420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4Z98_RS00425	COG3688	RNA-binding protein containing a PIN domain
E4Z98_RS00445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4Z98_RS00455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4Z98_RS00460	COG0572	uridine kinase
E4Z98_RS00490	COG2823	Periplasmic or secreted lipoprotein
E4Z98_RS00490	COG1652	LysM domain
E4Z98_RS00500	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E4Z98_RS00510	COG0737	Belongs to the 5'-nucleotidase family
E4Z98_RS00515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4Z98_RS00530	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4Z98_RS00545	COG2827	Endonuclease containing a URI domain
E4Z98_RS00550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E4Z98_RS00555	COG0204	Acyl-transferase
E4Z98_RS00570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4Z98_RS00575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E4Z98_RS00580	COG1760	l-serine dehydratase
E4Z98_RS00585	COG1760	l-serine dehydratase
E4Z98_RS00590	COG4109	DRTGG domain
E4Z98_RS00595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E4Z98_RS00600	COG0488	(ABC) transporter
E4Z98_RS00605	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4Z98_RS00635	COG0402	S-adenosylhomocysteine deaminase activity
E4Z98_RS00640	COG2233	PERMEase
E4Z98_RS00645	COG4166	transmembrane transport
E4Z98_RS00655	COG0601	transmembrane transport
E4Z98_RS00660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4Z98_RS00665	COG0444	Belongs to the ABC transporter superfamily
E4Z98_RS00670	COG4608	Belongs to the ABC transporter superfamily
E4Z98_RS00695	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E4Z98_RS00700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4Z98_RS00700	COG1263	PTS System
E4Z98_RS00705	COG0546	phosphoglycolate phosphatase activity
E4Z98_RS00710	COG1737	Transcriptional regulator
E4Z98_RS00720	COG0420	3'-5' exonuclease activity
E4Z98_RS00725	COG0419	ATPase involved in DNA repair
E4Z98_RS00730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E4Z98_RS00735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4Z98_RS00740	COG1132	(ABC) transporter
E4Z98_RS00760	COG2252	PERMEase
E4Z98_RS00785	COG0861	Integral membrane protein TerC family
E4Z98_RS00795	COG1028	Short-chain dehydrogenase reductase Sdr
E4Z98_RS00805	COG1846	Transcriptional regulator
E4Z98_RS00810	COG2814	Major facilitator Superfamily
E4Z98_RS00825	COG0561	phosphatase activity
E4Z98_RS00835	COG3711	transcriptional antiterminator
E4Z98_RS00840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4Z98_RS00840	COG2190	(PTS) system
E4Z98_RS00840	COG1263	PTS System
E4Z98_RS00845	COG2723	6-phospho-beta-galactosidase activity
E4Z98_RS00850	COG4152	abc transporter atp-binding protein
E4Z98_RS00855	COG1668	transmembrane transport
E4Z98_RS00870	COG3104	oligopeptide transport
E4Z98_RS00875	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E4Z98_RS00880	COG0827	DNA restriction-modification system
E4Z98_RS00885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4Z98_RS00890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4Z98_RS00895	COG0475	glutathione-regulated potassium exporter activity
E4Z98_RS00905	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4Z98_RS00920	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E4Z98_RS00945	COG2255	four-way junction helicase activity
E4Z98_RS00950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E4Z98_RS00955	COG0343	queuine tRNA-ribosyltransferase activity
E4Z98_RS00960	COG1862	Preprotein translocase
E4Z98_RS00970	COG1454	alcohol dehydrogenase
E4Z98_RS00970	COG1012	belongs to the aldehyde dehydrogenase family
E4Z98_RS00975	COG1792	Involved in formation and maintenance of cell shape
E4Z98_RS01020	COG4608	Belongs to the ABC transporter superfamily
E4Z98_RS01025	COG0444	Belongs to the ABC transporter superfamily
E4Z98_RS01030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4Z98_RS01035	COG0601	transmembrane transport
E4Z98_RS01045	COG4116	CYTH
E4Z98_RS01050	COG2357	RelA SpoT domain protein
E4Z98_RS01055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4Z98_RS01060	COG0564	pseudouridine synthase activity
E4Z98_RS01065	COG2239	Acts as a magnesium transporter
E4Z98_RS01075	COG3142	Participates in the control of copper homeostasis
E4Z98_RS01085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4Z98_RS01090	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4Z98_RS01100	COG1368	sulfuric ester hydrolase activity
E4Z98_RS01105	COG3706	GGDEF domain
E4Z98_RS01120	COG2738	Putative neutral zinc metallopeptidase
E4Z98_RS01135	COG0193	aminoacyl-tRNA hydrolase activity
E4Z98_RS01140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4Z98_RS01145	COG2244	polysaccharide biosynthetic process
E4Z98_RS01150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4Z98_RS01160	COG1098	S1 RNA binding domain
E4Z98_RS01165	COG0037	tRNA processing
E4Z98_RS01170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4Z98_RS01180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4Z98_RS01185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4Z98_RS01190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E4Z98_RS01280	COG1268	BioY protein
E4Z98_RS01285	COG2176	DNA-directed DNA polymerase activity
E4Z98_RS01290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4Z98_RS01295	COG0735	belongs to the Fur family
E4Z98_RS01450	COG4466	Protein conserved in bacteria
E4Z98_RS01455	COG2514	catechol 2,3-dioxygenase activity
E4Z98_RS01475	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
E4Z98_RS01480	COG1104	cysteine desulfurase activity
E4Z98_RS01485	COG0301	tRNA thio-modification
E4Z98_RS01490	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E4Z98_RS01535	COG0525	valine-tRNA ligase activity
E4Z98_RS01540	COG0285	dihydrofolate synthase activity
E4Z98_RS01545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4Z98_RS01560	COG2003	Belongs to the UPF0758 family
E4Z98_RS01565	COG1278	Cold shock
E4Z98_RS01575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4Z98_RS01585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4Z98_RS01595	COG1121	(ABC) transporter
E4Z98_RS01600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4Z98_RS01605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4Z98_RS01610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E4Z98_RS01615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4Z98_RS01625	COG1970	mechanosensitive ion channel activity
E4Z98_RS01630	COG0612	Peptidase, M16
E4Z98_RS01635	COG0612	Peptidase, M16
E4Z98_RS01640	COG0300	oxidoreductase activity
E4Z98_RS01645	COG1426	Protein conserved in bacteria
E4Z98_RS01650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4Z98_RS01685	COG0561	phosphatase activity
E4Z98_RS01690	COG0745	RESPONSE REGULATOR receiver
E4Z98_RS01695	COG3850	Histidine kinase
E4Z98_RS01695	COG5002	protein histidine kinase activity
E4Z98_RS01700	COG4476	Belongs to the UPF0223 family
E4Z98_RS01705	COG0483	inositol monophosphate 1-phosphatase activity
E4Z98_RS01710	COG1217	gtp-binding protein TYPA
E4Z98_RS01715	COG0191	fructose-bisphosphate aldolase activity
E4Z98_RS01720	COG2723	6-phospho-beta-galactosidase activity
E4Z98_RS01735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4Z98_RS01740	COG1459	type II secretion system
E4Z98_RS01745	COG4537	Required for transformation and DNA binding
E4Z98_RS01770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4Z98_RS01770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4Z98_RS01775	COG0084	hydrolase, TatD family'
E4Z98_RS01780	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E4Z98_RS01785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4Z98_RS01790	COG1960	acyl-CoA dehydrogenase activity
E4Z98_RS01795	COG0583	DNA-binding transcription factor activity
E4Z98_RS01800	COG0183	Belongs to the thiolase family
E4Z98_RS01805	COG1960	acyl-CoA dehydrogenase activity
E4Z98_RS01810	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4Z98_RS01815	COG1024	Enoyl-CoA hydratase
E4Z98_RS01820	COG0427	acetyl-CoA hydrolase
E4Z98_RS01825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4Z98_RS01830	COG3842	ATPase activity
E4Z98_RS01850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4Z98_RS01850	COG1263	PTS System
E4Z98_RS01850	COG2190	(PTS) system
E4Z98_RS01860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4Z98_RS01865	COG2017	converts alpha-aldose to the beta-anomer
E4Z98_RS01870	COG1609	Transcriptional regulator
E4Z98_RS01875	COG0366	Alpha amylase catalytic
E4Z98_RS01880	COG0366	Alpha amylase catalytic
E4Z98_RS01885	COG0366	Alpha amylase catalytic
E4Z98_RS01895	COG1175	transmembrane transport
E4Z98_RS01900	COG3833	ABC-type maltose transport systems, permease component
E4Z98_RS01915	COG1609	Transcriptional regulator
E4Z98_RS01925	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E4Z98_RS01930	COG2706	6-phosphogluconolactonase activity
E4Z98_RS01940	COG0628	permease
E4Z98_RS01945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4Z98_RS01955	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4Z98_RS01955	COG3942	CHAP domain
E4Z98_RS01965	COG1368	sulfuric ester hydrolase activity
E4Z98_RS01970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E4Z98_RS01975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4Z98_RS01980	COG4716	Myosin-crossreactive antigen
E4Z98_RS01995	COG2081	HI0933 family
E4Z98_RS02000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4Z98_RS02005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4Z98_RS02010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4Z98_RS02015	COG1120	ATPase activity
E4Z98_RS02025	COG1252	NADH dehydrogenase
E4Z98_RS02035	COG2910	NAD(P)H-binding
E4Z98_RS02050	COG2271	Major facilitator Superfamily
E4Z98_RS02055	COG1473	amidohydrolase
E4Z98_RS02075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4Z98_RS02075	COG0519	Catalyzes the synthesis of GMP from XMP
E4Z98_RS02080	COG1072	(Pantothenic acid kinase))
E4Z98_RS02085	COG1607	acyl-coa hydrolase
E4Z98_RS02095	COG2813	Specifically methylates the guanine in position
E4Z98_RS02100	COG0052	Belongs to the universal ribosomal protein uS2 family
E4Z98_RS02105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E4Z98_RS02110	COG0528	UMP kinase activity
E4Z98_RS02115	COG0233	cytoplasmic translational termination
E4Z98_RS02170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4Z98_RS02175	COG4589	Belongs to the CDS family
E4Z98_RS02180	COG0750	zinc metalloprotease
E4Z98_RS02185	COG0442	prolyl-tRNA aminoacylation
E4Z98_RS02190	COG2235	arginine
E4Z98_RS02195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4Z98_RS02200	COG0549	Belongs to the carbamate kinase family
E4Z98_RS02205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4Z98_RS02210	COG1288	antiporter activity
E4Z98_RS02215	COG1438	arginine binding
E4Z98_RS02225	COG0322	excinuclease ABC activity
E4Z98_RS02235	COG0210	DNA helicase
E4Z98_RS02240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E4Z98_RS02245	COG4851	CamS sex pheromone cAM373 precursor
E4Z98_RS02250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4Z98_RS02255	COG0154	amidase activity
E4Z98_RS02260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4Z98_RS02265	COG1597	lipid kinase activity
E4Z98_RS02270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4Z98_RS02280	COG4493	Belongs to the UPF0637 family
E4Z98_RS02295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4Z98_RS02300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4Z98_RS02325	COG1278	Cold shock
E4Z98_RS02330	COG4948	Mandelate Racemase Muconate Lactonizing
E4Z98_RS02335	COG0596	Alpha beta hydrolase
E4Z98_RS02340	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E4Z98_RS02345	COG1169	isochorismate synthase
E4Z98_RS02350	COG0318	PFAM AMP-dependent synthetase and ligase
E4Z98_RS02375	COG0531	amino acid
E4Z98_RS02395	COG0531	amino acid
E4Z98_RS02400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4Z98_RS02405	COG0768	penicillin binding
E4Z98_RS02410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4Z98_RS02415	COG0582	viral genome integration into host DNA
E4Z98_RS02430	COG1396	sequence-specific DNA binding
E4Z98_RS02450	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4Z98_RS02665	COG5632	N-Acetylmuramoyl-L-alanine amidase
E4Z98_RS02665	COG5263	repeat protein
E4Z98_RS02675	COG0571	ribonuclease III activity
E4Z98_RS02680	COG1196	nuclear chromosome segregation
E4Z98_RS02685	COG0561	phosphatase activity
E4Z98_RS02690	COG0552	protein localization to endoplasmic reticulum
E4Z98_RS02720	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4Z98_RS02720	COG3933	PFAM sigma-54 factor interaction domain-containing protein
E4Z98_RS02725	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4Z98_RS02725	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4Z98_RS02735	COG3715	PTS system
E4Z98_RS02740	COG3716	PTS system mannose fructose sorbose family IID component
E4Z98_RS02750	COG0006	proline dipeptidase activity
E4Z98_RS02755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E4Z98_RS02760	COG1302	Protein conserved in bacteria
E4Z98_RS02765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4Z98_RS02770	COG1570	exodeoxyribonuclease VII activity
E4Z98_RS02775	COG1722	exodeoxyribonuclease VII activity
E4Z98_RS02785	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E4Z98_RS02790	COG0497	DNA recombination
E4Z98_RS02795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4Z98_RS02810	COG1610	YqeY-like protein
E4Z98_RS02825	COG2814	Major facilitator Superfamily
E4Z98_RS02840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E4Z98_RS02850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E4Z98_RS02855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4Z98_RS02860	COG0705	Rhomboid family
E4Z98_RS02870	COG1940	carbohydrate kinase activity
E4Z98_RS02875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4Z98_RS02885	COG0542	response to heat
E4Z98_RS02890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4Z98_RS02895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4Z98_RS02900	COG0438	transferase activity, transferring glycosyl groups
E4Z98_RS02905	COG2084	Dehydrogenase
E4Z98_RS02920	COG0544	peptidyl-prolyl cis-trans isomerase activity
E4Z98_RS02925	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E4Z98_RS02930	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E4Z98_RS02935	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E4Z98_RS02940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4Z98_RS02945	COG1534	Rna-binding protein
E4Z98_RS02950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E4Z98_RS02955	COG1713	HD superfamily hydrolase involved in NAD metabolism
E4Z98_RS02960	COG0799	negative regulation of ribosome biogenesis
E4Z98_RS02965	COG2226	methyltransferase
E4Z98_RS02975	COG0516	GMP reductase activity
E4Z98_RS02985	COG0351	phosphomethylpyrimidine kinase
E4Z98_RS02990	COG0351	phosphomethylpyrimidine kinase
E4Z98_RS02995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4Z98_RS03005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4Z98_RS03010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4Z98_RS03015	COG2070	2-Nitropropane dioxygenase
E4Z98_RS03020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4Z98_RS03030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4Z98_RS03040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E4Z98_RS03045	COG0439	Biotin carboxylase
E4Z98_RS03050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4Z98_RS03055	COG0825	malonyl-CoA metabolic process
E4Z98_RS03075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4Z98_RS03080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4Z98_RS03090	COG2217	Heavy metal translocating P-type atpase
E4Z98_RS03100	COG0513	Belongs to the DEAD box helicase family
E4Z98_RS03105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4Z98_RS03120	COG3711	transcriptional antiterminator
E4Z98_RS03125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4Z98_RS03130	COG0246	Mannitol dehydrogenase
E4Z98_RS03140	COG1214	PFAM Peptidase M22, glycoprotease
E4Z98_RS03145	COG0456	acetyltransferase
E4Z98_RS03155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E4Z98_RS03165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E4Z98_RS03185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4Z98_RS03205	COG4585	Histidine kinase
E4Z98_RS03210	COG2197	response regulator
E4Z98_RS03215	COG0569	domain protein
E4Z98_RS03220	COG4841	protein insertion into membrane
E4Z98_RS03230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4Z98_RS03235	COG4838	Belongs to the UPF0358 family
E4Z98_RS03240	COG0772	Belongs to the SEDS family
E4Z98_RS03245	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E4Z98_RS03255	COG3679	Belongs to the UPF0342 family
E4Z98_RS03260	COG4471	UPF0298 protein
E4Z98_RS03265	COG0742	ribosomal rna small subunit methyltransferase
E4Z98_RS03270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E4Z98_RS03275	COG3480	Lon protease (S16) C-terminal proteolytic domain
E4Z98_RS03280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4Z98_RS03290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4Z98_RS03300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4Z98_RS03300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E4Z98_RS03305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E4Z98_RS03310	COG0237	dephospho-CoA kinase activity
E4Z98_RS03315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E4Z98_RS03325	COG1484	DNA-dependent DNA replication
E4Z98_RS03335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E4Z98_RS03340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4Z98_RS03345	COG0745	RESPONSE REGULATOR receiver
E4Z98_RS03350	COG5002	protein histidine kinase activity
E4Z98_RS03360	COG0706	membrane insertase activity
E4Z98_RS03365	COG1254	Belongs to the acylphosphatase family
E4Z98_RS03370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4Z98_RS03380	COG1733	regulation of RNA biosynthetic process
E4Z98_RS03385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E4Z98_RS03390	COG0072	phenylalanine-tRNA ligase activity
E4Z98_RS03390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4Z98_RS03400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4Z98_RS03405	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E4Z98_RS03410	COG0622	Phosphoesterase
E4Z98_RS03425	COG0640	Transcriptional regulator
E4Z98_RS03440	COG1950	PFAM Membrane protein of
E4Z98_RS03445	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E4Z98_RS03460	COG1253	flavin adenine dinucleotide binding
E4Z98_RS03475	COG2723	6-phospho-beta-galactosidase activity
E4Z98_RS03490	COG0671	phosphoesterase, PA-phosphatase related
E4Z98_RS03495	COG2076	Multidrug Resistance protein
E4Z98_RS03500	COG2076	Multidrug Resistance protein
E4Z98_RS03510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4Z98_RS03525	COG0531	amino acid
E4Z98_RS03530	COG1263	PTS System
E4Z98_RS03530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4Z98_RS03535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4Z98_RS03550	COG0281	malic enzyme
E4Z98_RS03555	COG0114	fumarate hydratase activity
E4Z98_RS03560	COG3594	Acyltransferase
E4Z98_RS03575	COG1126	abc transporter atp-binding protein
E4Z98_RS03580	COG0765	amino acid transport
E4Z98_RS03585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E4Z98_RS03590	COG4485	Bacterial membrane protein, YfhO
E4Z98_RS03600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4Z98_RS03605	COG1435	thymidine kinase activity
E4Z98_RS03610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E4Z98_RS03615	COG2890	protein-(glutamine-N5) methyltransferase activity
E4Z98_RS03620	COG0009	L-threonylcarbamoyladenylate synthase
E4Z98_RS03625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E4Z98_RS03630	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E4Z98_RS03635	COG0772	Belongs to the SEDS family
E4Z98_RS03640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4Z98_RS03645	COG1301	dicarboxylic acid transport
E4Z98_RS03650	COG0367	asparagine synthase
E4Z98_RS03655	COG0383	alpha-mannosidase activity
E4Z98_RS03660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4Z98_RS03675	COG0105	UTP biosynthetic process
E4Z98_RS03680	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
E4Z98_RS03710	COG0039	L-malate dehydrogenase activity
E4Z98_RS03720	COG0745	RESPONSE REGULATOR receiver
E4Z98_RS03725	COG5002	protein histidine kinase activity
E4Z98_RS03730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4Z98_RS03735	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E4Z98_RS03745	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E4Z98_RS03750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4Z98_RS03755	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E4Z98_RS03765	COG1307	EDD domain protein, DegV family
E4Z98_RS03775	COG0587	DNA-directed DNA polymerase activity
E4Z98_RS03780	COG0205	6-phosphofructokinase activity
E4Z98_RS03790	COG3409	Peptidoglycan-binding domain 1 protein
E4Z98_RS03790	COG0793	Belongs to the peptidase S41A family
E4Z98_RS03795	COG0681	Belongs to the peptidase S26 family
E4Z98_RS03800	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E4Z98_RS03805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4Z98_RS03810	COG0758	DNA mediated transformation
E4Z98_RS03815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E4Z98_RS03820	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E4Z98_RS03825	COG4974	Belongs to the 'phage' integrase family
E4Z98_RS03830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E4Z98_RS03835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E4Z98_RS03845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E4Z98_RS03855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4Z98_RS03870	COG0556	nucleotide-excision repair
E4Z98_RS03875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4Z98_RS03880	COG1660	Displays ATPase and GTPase activities
E4Z98_RS03885	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E4Z98_RS03890	COG1481	regulation of sporulation
E4Z98_RS03900	COG0740	serine-type endopeptidase activity
E4Z98_RS03915	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4Z98_RS03925	COG0557	exoribonuclease II activity
E4Z98_RS03930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E4Z98_RS03935	COG0356	it plays a direct role in the translocation of protons across the membrane
E4Z98_RS03940	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4Z98_RS03945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4Z98_RS03950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4Z98_RS03955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4Z98_RS03960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4Z98_RS03965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E4Z98_RS03980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4Z98_RS03990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E4Z98_RS03995	COG1940	carbohydrate kinase activity
E4Z98_RS04020	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E4Z98_RS04025	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E4Z98_RS04030	COG0546	phosphoglycolate phosphatase activity
E4Z98_RS04035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E4Z98_RS04040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4Z98_RS04050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4Z98_RS04070	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E4Z98_RS04075	COG1074	ATP-dependent DNA helicase activity
E4Z98_RS04080	COG0217	transcriptional regulatory protein
E4Z98_RS04100	COG2261	transglycosylase associated protein
E4Z98_RS04105	COG0778	Nitroreductase
E4Z98_RS04110	COG0504	CTP synthase activity
E4Z98_RS04125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4Z98_RS04130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E4Z98_RS04135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4Z98_RS04140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4Z98_RS04150	COG4684	Psort location CytoplasmicMembrane, score
E4Z98_RS04155	COG1309	transcriptional regulator
E4Z98_RS04160	COG0187	DNA topoisomerase II activity
E4Z98_RS04165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E4Z98_RS04180	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
E4Z98_RS04185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4Z98_RS04190	COG0228	four-way junction DNA binding
E4Z98_RS04195	COG1846	Transcriptional regulator
E4Z98_RS04195	COG0456	acetyltransferase
E4Z98_RS04200	COG2321	neutral zinc metallopeptidase
E4Z98_RS04210	COG1136	(ABC) transporter
E4Z98_RS04220	COG1428	Deoxynucleoside kinase
E4Z98_RS04225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4Z98_RS04230	COG1882	Formate acetyltransferase
E4Z98_RS04235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E4Z98_RS04240	COG1027	Aspartate ammonia-lyase
E4Z98_RS04245	COG1227	inorganic diphosphatase activity
E4Z98_RS04255	COG3442	glutamine amidotransferase
E4Z98_RS04260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4Z98_RS04265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4Z98_RS04280	COG2608	mercury ion transmembrane transporter activity
E4Z98_RS04285	COG2217	Heavy metal translocating P-type atpase
E4Z98_RS04290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4Z98_RS04295	COG0336	Belongs to the RNA methyltransferase TrmD family
E4Z98_RS04300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4Z98_RS04305	COG3331	DNA recombination
E4Z98_RS04310	COG4474	Belongs to the UPF0398 family
E4Z98_RS04325	COG0116	Belongs to the methyltransferase superfamily
E4Z98_RS04330	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E4Z98_RS04335	COG1288	antiporter activity
E4Z98_RS04340	COG1307	EDD domain protein, DegV family
E4Z98_RS04350	COG0328	RNA-DNA hybrid ribonuclease activity
E4Z98_RS04360	COG1278	Cold shock
E4Z98_RS04375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E4Z98_RS04380	COG0564	pseudouridine synthase activity
E4Z98_RS04385	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E4Z98_RS04395	COG0540	Belongs to the ATCase OTCase family
E4Z98_RS04400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4Z98_RS04405	COG0505	Belongs to the CarA family
E4Z98_RS04410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4Z98_RS04415	COG0543	2 iron, 2 sulfur cluster binding
E4Z98_RS04425	COG0284	orotidine-5'-phosphate decarboxylase activity
E4Z98_RS04435	COG3338	carbonate dehydratase activity
E4Z98_RS04445	COG0745	RESPONSE REGULATOR receiver
E4Z98_RS04455	COG1942	4-Oxalocrotonate Tautomerase
E4Z98_RS04460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E4Z98_RS04465	COG0584	glycerophosphoryl diester phosphodiesterase
E4Z98_RS04470	COG0335	large ribosomal subunit rRNA binding
E4Z98_RS04475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4Z98_RS04475	COG0730	response to heat
E4Z98_RS04495	COG4894	glucomannan catabolic process
E4Z98_RS04500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4Z98_RS04510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4Z98_RS04515	COG2151	metal-sulfur cluster biosynthetic enzyme
E4Z98_RS04535	COG2723	6-phospho-beta-galactosidase activity
E4Z98_RS04540	COG1199	ATP-dependent helicase activity
E4Z98_RS04540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4Z98_RS04550	COG0436	Aminotransferase
E4Z98_RS04560	COG1725	Transcriptional regulator
E4Z98_RS04565	COG1131	(ABC) transporter
E4Z98_RS04575	COG0577	efflux transmembrane transporter activity
E4Z98_RS04580	COG1136	(ABC) transporter
E4Z98_RS04590	COG0358	DNA primase activity
E4Z98_RS04595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4Z98_RS04600	COG0710	3-dehydroquinate dehydratase activity
E4Z98_RS04605	COG2384	SAM-dependent methyltransferase
E4Z98_RS04610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4Z98_RS04615	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4Z98_RS04630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4Z98_RS04635	COG1011	Hydrolase
E4Z98_RS04645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E4Z98_RS04650	COG3763	UPF0154 protein
E4Z98_RS04655	COG1132	(ABC) transporter
E4Z98_RS04660	COG1132	(ABC) transporter
E4Z98_RS04665	COG2207	Transcriptional regulator
E4Z98_RS04665	COG4753	response regulator
E4Z98_RS04670	COG2972	Histidine kinase
E4Z98_RS04675	COG1879	ABC-type sugar transport system periplasmic component
E4Z98_RS04690	COG4211	Belongs to the binding-protein-dependent transport system permease family
E4Z98_RS04695	COG0534	Mate efflux family protein
E4Z98_RS04700	COG0492	ferredoxin-NADP+ reductase activity
E4Z98_RS04705	COG1323	Belongs to the UPF0348 family
E4Z98_RS04710	COG1136	(ABC) transporter
E4Z98_RS04720	COG0228	four-way junction DNA binding
E4Z98_RS04725	COG1837	Belongs to the UPF0109 family
E4Z98_RS04740	COG2814	Major facilitator Superfamily
E4Z98_RS04755	COG2723	6-phospho-beta-galactosidase activity
E4Z98_RS04760	COG2188	Transcriptional regulator
E4Z98_RS04765	COG2267	carboxylic ester hydrolase activity
E4Z98_RS04795	COG3425	synthase
E4Z98_RS04800	COG1846	Transcriptional regulator
E4Z98_RS04805	COG0346	lactoylglutathione lyase activity
E4Z98_RS04810	COG0346	lactoylglutathione lyase activity
E4Z98_RS04815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4Z98_RS04825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4Z98_RS04835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E4Z98_RS04840	COG1234	tRNA 3'-trailer cleavage
E4Z98_RS04845	COG0300	oxidoreductase activity
E4Z98_RS04855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E4Z98_RS04855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4Z98_RS04860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4Z98_RS04875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4Z98_RS04880	COG4974	Belongs to the 'phage' integrase family
E4Z98_RS04890	COG1012	belongs to the aldehyde dehydrogenase family
E4Z98_RS04895	COG4607	ABC-type enterochelin transport system periplasmic component
E4Z98_RS04900	COG4604	ABC transporter, ATP-binding protein
E4Z98_RS04905	COG4605	iron ion homeostasis
E4Z98_RS04910	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4Z98_RS04915	COG2755	lipolytic protein G-D-S-L family
E4Z98_RS04915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4Z98_RS04925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4Z98_RS04935	COG2755	lipolytic protein G-D-S-L family
E4Z98_RS04940	COG1307	EDD domain protein, DegV family
E4Z98_RS04945	COG1272	protein, Hemolysin III
E4Z98_RS04960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4Z98_RS04965	COG1803	Methylglyoxal synthase
E4Z98_RS04970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E4Z98_RS04975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4Z98_RS04980	COG0488	(ABC) transporter
E4Z98_RS04995	COG0617	tRNA 3'-terminal CCA addition
E4Z98_RS05000	COG1694	Mazg nucleotide pyrophosphohydrolase
E4Z98_RS05005	COG5582	Belongs to the UPF0302 family
E4Z98_RS05020	COG1160	GTP binding
E4Z98_RS05025	COG0539	negative regulation of cytoplasmic translation
E4Z98_RS05040	COG0514	ATP-dependent DNA helicase (RecQ)
E4Z98_RS05055	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E4Z98_RS05060	COG1187	pseudouridine synthase activity
E4Z98_RS05065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4Z98_RS05070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4Z98_RS05075	COG4974	Belongs to the 'phage' integrase family
E4Z98_RS05080	COG0735	belongs to the Fur family
E4Z98_RS05090	COG2996	Protein conserved in bacteria
E4Z98_RS05095	COG2252	PERMEase
E4Z98_RS05100	COG1914	H( )-stimulated, divalent metal cation uptake system
E4Z98_RS05240	COG4974	Belongs to the 'phage' integrase family
E4Z98_RS05250	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4Z98_RS05255	COG0149	triose-phosphate isomerase activity
E4Z98_RS05260	COG0126	phosphoglycerate kinase activity
E4Z98_RS05265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4Z98_RS05275	COG0038	chloride channel
E4Z98_RS05280	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4Z98_RS05310	COG0673	inositol 2-dehydrogenase activity
E4Z98_RS05315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4Z98_RS05315	COG0517	IMP dehydrogenase activity
E4Z98_RS05320	COG1136	(ABC) transporter
E4Z98_RS05345	COG1609	Transcriptional regulator
E4Z98_RS05350	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4Z98_RS05355	COG0484	heat shock protein binding
E4Z98_RS05360	COG0443	Heat shock 70 kDa protein
E4Z98_RS05365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E4Z98_RS05370	COG1420	regulation of RNA biosynthetic process
E4Z98_RS05375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4Z98_RS05380	COG0196	riboflavin kinase activity
E4Z98_RS05385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4Z98_RS05390	COG2814	Major facilitator Superfamily
E4Z98_RS05395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E4Z98_RS05410	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E4Z98_RS05415	COG0195	Participates in both transcription termination and antitermination
E4Z98_RS05420	COG0779	Required for maturation of 30S ribosomal subunits
E4Z98_RS05425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4Z98_RS05430	COG2116	formate transmembrane transporter activity
E4Z98_RS05435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4Z98_RS05445	COG1040	competence protein
E4Z98_RS05450	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E4Z98_RS05465	COG1739	Uncharacterized protein family UPF0029
E4Z98_RS05470	COG2188	Transcriptional regulator
E4Z98_RS05480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4Z98_RS05495	COG0668	transmembrane transport
E4Z98_RS05505	COG3404	Formiminotransferase-cyclodeaminase
E4Z98_RS05510	COG0151	Belongs to the GarS family
E4Z98_RS05535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4Z98_RS05540	COG0047	phosphoribosylformylglycinamidine synthase activity
E4Z98_RS05545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4Z98_RS05550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4Z98_RS05555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4Z98_RS05560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4Z98_RS05565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4Z98_RS05570	COG0704	Plays a role in the regulation of phosphate uptake
E4Z98_RS05575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4Z98_RS05580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4Z98_RS05585	COG0581	inorganic phosphate transmembrane transporter activity
E4Z98_RS05590	COG0573	inorganic phosphate transmembrane transporter activity
E4Z98_RS05595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4Z98_RS05600	COG2177	Part of the ABC transporter FtsEX involved in
E4Z98_RS05605	COG2884	Cell division ATP-binding protein ftsE
E4Z98_RS05615	COG0653	protein targeting
E4Z98_RS05635	COG0481	GTPase activity
E4Z98_RS05640	COG0542	response to heat
E4Z98_RS05655	COG0751	glycine-tRNA ligase activity
E4Z98_RS05660	COG0752	glycyl-tRNA synthetase alpha subunit
E4Z98_RS05665	COG1381	Involved in DNA repair and RecF pathway recombination
E4Z98_RS05670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4Z98_RS05675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E4Z98_RS05680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E4Z98_RS05690	COG1702	phosphate starvation-inducible protein PhoH
E4Z98_RS05695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E4Z98_RS05700	COG0025	NhaP-type Na H and K H
E4Z98_RS05705	COG0183	Belongs to the thiolase family
E4Z98_RS05710	COG1280	lysine exporter protein (LysE YggA)
E4Z98_RS05710	COG1674	ftsk spoiiie
E4Z98_RS05730	COG1464	Belongs to the NlpA lipoprotein family
E4Z98_RS05735	COG2011	ABC-type metal ion transport system permease component
E4Z98_RS05740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4Z98_RS05745	COG0509	glycine decarboxylation via glycine cleavage system
E4Z98_RS05750	COG1393	Belongs to the ArsC family
E4Z98_RS05775	COG0667	Aldo Keto reductase
E4Z98_RS05780	COG0534	Mate efflux family protein
E4Z98_RS05790	COG0656	L-ascorbic acid biosynthetic process
E4Z98_RS05800	COG2261	transglycosylase associated protein
E4Z98_RS05805	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E4Z98_RS05815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4Z98_RS05815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4Z98_RS05820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4Z98_RS05820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4Z98_RS05820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4Z98_RS05825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4Z98_RS05825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4Z98_RS05825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4Z98_RS05830	COG3711	transcriptional antiterminator
E4Z98_RS05830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4Z98_RS05840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4Z98_RS05850	COG1373	ATPase (AAA superfamily
E4Z98_RS05875	COG1401	restriction endodeoxyribonuclease activity
E4Z98_RS05885	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4Z98_RS05890	COG3457	Alanine racemase
E4Z98_RS05900	COG2188	Transcriptional regulator
E4Z98_RS05905	COG0626	cystathionine gamma-synthase activity
E4Z98_RS05910	COG1735	metal-dependent hydrolase with the TIM-barrel fold
E4Z98_RS05925	COG1473	amidohydrolase
E4Z98_RS05930	COG2723	6-phospho-beta-galactosidase activity
E4Z98_RS05935	COG2190	(PTS) system
E4Z98_RS05935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4Z98_RS05935	COG1263	PTS System
E4Z98_RS05940	COG3711	transcriptional antiterminator
E4Z98_RS05945	COG0719	Fe-S assembly protein
E4Z98_RS05955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4Z98_RS05960	COG0719	Fe-S assembly protein
E4Z98_RS05975	COG0482	sulfurtransferase activity
E4Z98_RS06050	COG1104	cysteine desulfurase activity
E4Z98_RS06055	COG0768	penicillin binding
E4Z98_RS06060	COG1879	ABC-type sugar transport system periplasmic component
E4Z98_RS06065	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4Z98_RS06075	COG1869	D-ribose catabolic process
E4Z98_RS06080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4Z98_RS06085	COG1609	Transcriptional regulator
E4Z98_RS06090	COG1335	isochorismatase
E4Z98_RS06095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4Z98_RS06115	COG3853	Toxic anion resistance protein (TelA)
E4Z98_RS06120	COG1196	nuclear chromosome segregation
E4Z98_RS06120	COG0741	lytic transglycosylase activity
E4Z98_RS06120	COG0739	heme binding
E4Z98_RS06130	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4Z98_RS06130	COG2918	glutathione biosynthetic process
E4Z98_RS06165	COG0601	transmembrane transport
E4Z98_RS06170	COG4608	Belongs to the ABC transporter superfamily
E4Z98_RS06180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4Z98_RS06185	COG0416	fatty acid biosynthetic process
E4Z98_RS06190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4Z98_RS06195	COG1461	Dihydroxyacetone kinase
E4Z98_RS06205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4Z98_RS06210	COG1564	THIamine pyrophosphokinase
E4Z98_RS06215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4Z98_RS06220	COG1162	GTPase activity
E4Z98_RS06225	COG0515	serine threonine protein kinase
E4Z98_RS06225	COG2815	serine threonine protein kinase
E4Z98_RS06235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4Z98_RS06235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4Z98_RS06240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4Z98_RS06245	COG0242	peptide deformylase activity
E4Z98_RS06250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4Z98_RS06260	COG0194	GDP metabolic process
E4Z98_RS06265	COG1561	YicC-like family, N-terminal region
E4Z98_RS06270	COG4443	Transcriptional Coactivator p15 (PC4)
E4Z98_RS06285	COG0736	holo-[acyl-carrier-protein] synthase activity
E4Z98_RS06295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4Z98_RS06300	COG1181	Belongs to the D-alanine--D-alanine ligase family
E4Z98_RS06310	COG3764	Sortase (surface protein transpeptidase)
E4Z98_RS06360	COG3942	CHAP domain
E4Z98_RS06360	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4Z98_RS06380	COG0681	Belongs to the peptidase S26 family
E4Z98_RS06385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4Z98_RS06395	COG0495	leucyl-tRNA aminoacylation
E4Z98_RS06400	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4Z98_RS06400	COG1388	LysM domain
E4Z98_RS06415	COG0671	phosphoesterase, PA-phosphatase related
E4Z98_RS06420	COG1242	4 iron, 4 sulfur cluster binding
E4Z98_RS06425	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E4Z98_RS06430	COG0477	Major facilitator Superfamily
E4Z98_RS06440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E4Z98_RS06450	COG0222	ribosome binding
E4Z98_RS06455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E4Z98_RS06460	COG0081	regulation of translation
E4Z98_RS06465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E4Z98_RS06475	COG0250	Participates in transcription elongation, termination and antitermination
E4Z98_RS06485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4Z98_RS06495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4Z98_RS06500	COG3599	regulation of cell shape
E4Z98_RS06505	COG2302	S4 RNA-binding domain
E4Z98_RS06515	COG1799	cell septum assembly
E4Z98_RS06520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E4Z98_RS06530	COG0849	cell division
E4Z98_RS06535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4Z98_RS06540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E4Z98_RS06545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E4Z98_RS06550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4Z98_RS06555	COG0768	penicillin binding
E4Z98_RS06565	COG0275	rRNA processing
E4Z98_RS06570	COG2001	Belongs to the MraZ family
E4Z98_RS06615	COG1098	S1 RNA binding domain
E4Z98_RS06625	COG0492	ferredoxin-NADP+ reductase activity
E4Z98_RS06630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4Z98_RS06640	COG0647	UMP catabolic process
E4Z98_RS06645	COG4470	Protein conserved in bacteria
E4Z98_RS06650	COG0737	Belongs to the 5'-nucleotidase family
E4Z98_RS06655	COG2365	Tyrosine phosphatase family
E4Z98_RS06660	COG0783	Belongs to the Dps family
E4Z98_RS06665	COG3118	belongs to the thioredoxin family
E4Z98_RS06670	COG1193	negative regulation of DNA recombination
E4Z98_RS06680	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E4Z98_RS06685	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4Z98_RS06695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4Z98_RS06700	COG1394	ATPase activity, coupled to movement of substances
E4Z98_RS06705	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E4Z98_RS06710	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E4Z98_RS06715	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4Z98_RS06725	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E4Z98_RS06730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4Z98_RS06735	COG1269	ATP hydrolysis coupled proton transport
E4Z98_RS06745	COG3906	Belongs to the UPF0473 family
E4Z98_RS06750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4Z98_RS06755	COG4472	Bacterial protein of unknown function (DUF965)
E4Z98_RS06760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4Z98_RS06765	COG0589	response to stress
E4Z98_RS06770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4Z98_RS06775	COG1363	Peptidase, m42
E4Z98_RS06785	COG1464	Belongs to the NlpA lipoprotein family
E4Z98_RS06790	COG2011	ABC-type metal ion transport system permease component
E4Z98_RS06795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4Z98_RS06800	COG1132	(ABC) transporter
E4Z98_RS06815	COG0510	thiamine kinase activity
E4Z98_RS06820	COG4473	ABC transporter
E4Z98_RS06825	COG1131	(ABC) transporter
E4Z98_RS06830	COG0537	adenosine 5'-monophosphoramidase activity
E4Z98_RS06840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4Z98_RS06845	COG3481	metal-dependent phosphohydrolase, HD sub domain
E4Z98_RS06850	COG4717	serine-type aminopeptidase activity
E4Z98_RS06860	COG3679	Belongs to the UPF0342 family
E4Z98_RS06865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4Z98_RS06870	COG0564	pseudouridine synthase activity
E4Z98_RS06875	COG0018	arginyl-trna synthetase
E4Z98_RS06890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4Z98_RS06900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4Z98_RS06910	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E4Z98_RS06920	COG2910	NAD(P)H-binding
E4Z98_RS06925	COG3091	SprT-like family
E4Z98_RS06930	COG2183	response to ionizing radiation
E4Z98_RS06945	COG1288	antiporter activity
E4Z98_RS06950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4Z98_RS06955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4Z98_RS06960	COG1126	abc transporter atp-binding protein
E4Z98_RS06965	COG0765	amino acid transport
E4Z98_RS06975	COG2814	Major facilitator Superfamily
E4Z98_RS06980	COG0789	Transcriptional regulator
E4Z98_RS07005	COG4989	oxidoreductase activity
E4Z98_RS07010	COG1802	Transcriptional regulator
E4Z98_RS07015	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4Z98_RS07020	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4Z98_RS07025	COG1876	peptidase activity
E4Z98_RS07035	COG4129	membrane
E4Z98_RS07055	COG3343	RNA polymerase activity
E4Z98_RS07065	COG0095	Lipoate-protein ligase
E4Z98_RS07070	COG1078	dGTPase activity
E4Z98_RS07075	COG0561	phosphatase activity
E4Z98_RS07080	COG0346	lactoylglutathione lyase activity
E4Z98_RS07095	COG4467	Involved in initiation control of chromosome replication
E4Z98_RS07100	COG1774	PSP1 C-terminal conserved region
E4Z98_RS07105	COG0470	DNA polymerase III
E4Z98_RS07110	COG3870	Protein conserved in bacteria
E4Z98_RS07115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E4Z98_RS07120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4Z98_RS07125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E4Z98_RS07130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4Z98_RS07155	COG0590	tRNA wobble adenosine to inosine editing
E4Z98_RS07170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4Z98_RS07175	COG1780	Probably involved in ribonucleotide reductase function
E4Z98_RS07180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4Z98_RS07185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4Z98_RS07190	COG1011	Hydrolase
E4Z98_RS07195	COG4862	establishment of competence for transformation
E4Z98_RS07200	COG1393	Belongs to the ArsC family
E4Z98_RS07205	COG0180	Tryptophanyl-tRNA synthetase
E4Z98_RS07220	COG0095	Lipoate-protein ligase
E4Z98_RS07225	COG1234	tRNA 3'-trailer cleavage
E4Z98_RS07230	COG1363	Peptidase, m42
E4Z98_RS07245	COG1253	flavin adenine dinucleotide binding
E4Z98_RS07250	COG0628	permease
E4Z98_RS07260	COG0367	asparagine synthase
E4Z98_RS07265	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4Z98_RS07270	COG1132	(ABC) transporter
E4Z98_RS07300	COG1136	(ABC) transporter
E4Z98_RS07305	COG0577	efflux transmembrane transporter activity
E4Z98_RS07315	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4Z98_RS07320	COG1741	Belongs to the pirin family
E4Z98_RS07325	COG1113	amino acid transport
E4Z98_RS07340	COG1129	ABC transporter
E4Z98_RS07350	COG0583	DNA-binding transcription factor activity
E4Z98_RS07360	COG1486	melibiose metabolic process
E4Z98_RS07370	COG0657	acetylesterase activity
E4Z98_RS07375	COG2233	PERMEase
E4Z98_RS07380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E4Z98_RS07385	COG1136	(ABC) transporter
E4Z98_RS07385	COG0577	efflux transmembrane transporter activity
E4Z98_RS07390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E4Z98_RS07400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E4Z98_RS07405	COG1473	amidohydrolase
E4Z98_RS07415	COG0431	NADPH-dependent FMN reductase
E4Z98_RS07420	COG1376	ErfK ybiS ycfS ynhG family protein
E4Z98_RS07425	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4Z98_RS07430	COG0640	Transcriptional regulator
E4Z98_RS07435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4Z98_RS07525	COG0582	viral genome integration into host DNA
E4Z98_RS07530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4Z98_RS07535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E4Z98_RS07540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4Z98_RS07545	COG0803	Belongs to the bacterial solute-binding protein 9 family
E4Z98_RS07550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4Z98_RS07555	COG1121	(ABC) transporter
E4Z98_RS07565	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4Z98_RS07570	COG1611	Belongs to the LOG family
E4Z98_RS07590	COG0166	Belongs to the GPI family
E4Z98_RS07605	COG1473	amidohydrolase
E4Z98_RS07615	COG2388	GCN5-related N-acetyl-transferase
E4Z98_RS07625	COG1185	polyribonucleotide nucleotidyltransferase activity
E4Z98_RS07630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E4Z98_RS07640	COG0242	peptide deformylase activity
E4Z98_RS07650	COG1346	cytolysis
E4Z98_RS07655	COG1380	Effector of murein hydrolase LrgA
E4Z98_RS07660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E4Z98_RS07685	COG0436	Aminotransferase
E4Z98_RS07695	COG1321	iron dependent repressor
E4Z98_RS07700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4Z98_RS07705	COG3428	Bacterial PH domain
E4Z98_RS07715	COG3402	PFAM membrane-flanked domain
E4Z98_RS07725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E4Z98_RS07730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E4Z98_RS07735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E4Z98_RS07740	COG0124	histidyl-tRNA synthetase
E4Z98_RS07745	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4Z98_RS07745	COG4991	sh3 domain protein
E4Z98_RS07745	COG3103	Sh3 type 3 domain protein
E4Z98_RS07750	COG1490	D-aminoacyl-tRNA deacylase activity
E4Z98_RS07755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4Z98_RS07760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4Z98_RS07765	COG2264	protein methyltransferase activity
E4Z98_RS07775	COG1263	PTS System
E4Z98_RS07775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4Z98_RS07785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4Z98_RS07800	COG0589	response to stress
E4Z98_RS07810	COG0531	amino acid
E4Z98_RS07820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4Z98_RS07830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4Z98_RS07835	COG3655	Transcriptional regulator
E4Z98_RS07850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E4Z98_RS07855	COG1132	(ABC) transporter
E4Z98_RS07860	COG1132	(ABC) transporter
E4Z98_RS07880	COG0659	secondary active sulfate transmembrane transporter activity
E4Z98_RS07885	COG3557	Belongs to the UPF0374 family
E4Z98_RS07895	COG1194	a g-specific adenine glycosylase
E4Z98_RS07900	COG2137	regulation of response to DNA damage stimulus
E4Z98_RS07935	COG1316	TRANSCRIPTIONal
E4Z98_RS07945	COG4464	protein tyrosine phosphatase activity
E4Z98_RS07955	COG3944	biosynthesis protein
E4Z98_RS07965	COG0791	NLP P60 protein
E4Z98_RS07980	COG0463	Glycosyl transferase, family 2
E4Z98_RS07985	COG2246	polysaccharide biosynthetic process
E4Z98_RS07990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4Z98_RS07990	COG0463	Glycosyl transferase, family 2
E4Z98_RS08005	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4Z98_RS08015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4Z98_RS08020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4Z98_RS08045	COG1682	transport, permease protein
E4Z98_RS08050	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E4Z98_RS08055	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E4Z98_RS08060	COG1134	teichoic acid transport
E4Z98_RS08065	COG1316	TRANSCRIPTIONal
E4Z98_RS08070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4Z98_RS08075	COG1295	ribonuclease BN
E4Z98_RS08080	COG0024	Methionine aminopeptidase
E4Z98_RS08085	COG0716	FMN binding
E4Z98_RS08095	COG2309	aminopeptidase activity
E4Z98_RS08130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4Z98_RS08140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4Z98_RS08165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4Z98_RS08170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4Z98_RS08180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4Z98_RS08185	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E4Z98_RS08185	COG3933	PFAM sigma-54 factor interaction domain-containing protein
E4Z98_RS08190	COG0513	Belongs to the DEAD box helicase family
E4Z98_RS08195	COG0673	inositol 2-dehydrogenase activity
E4Z98_RS08205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4Z98_RS08210	COG1132	(ABC) transporter
E4Z98_RS08220	COG5503	Protein of unknown function (DUF1447)
E4Z98_RS08245	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E4Z98_RS08250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4Z98_RS08255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E4Z98_RS08260	COG0584	glycerophosphoryl diester phosphodiesterase
E4Z98_RS08270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4Z98_RS08275	COG1546	Belongs to the CinA family
E4Z98_RS08275	COG1058	Belongs to the CinA family
E4Z98_RS08285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4Z98_RS08290	COG1392	Phosphate transport regulator
E4Z98_RS08295	COG0306	phosphate transporter
E4Z98_RS08300	COG0268	Binds directly to 16S ribosomal RNA
E4Z98_RS08305	COG0726	polysaccharide deacetylase
E4Z98_RS08330	COG1466	dna polymerase III delta subunit
E4Z98_RS08335	COG0514	ATP-dependent DNA helicase (RecQ)
E4Z98_RS08340	COG0658	competence protein
E4Z98_RS08340	COG2333	competence protein COMEC
E4Z98_RS08345	COG2131	deaminase
E4Z98_RS08350	COG1596	polysaccharide export
E4Z98_RS08350	COG1555	photosystem II stabilization
E4Z98_RS08360	COG3397	chitin binding
E4Z98_RS08375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4Z98_RS08395	COG0459	protein refolding
E4Z98_RS08405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E4Z98_RS08425	COG1278	Cold shock
E4Z98_RS08435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E4Z98_RS08440	COG2153	protein acetylation
E4Z98_RS08445	COG0708	Exodeoxyribonuclease III
E4Z98_RS08455	COG1482	cell wall glycoprotein biosynthetic process
E4Z98_RS08490	COG0765	amino acid transport
E4Z98_RS08500	COG1968	undecaprenyl-diphosphatase activity
E4Z98_RS08535	COG0424	maF-like protein
E4Z98_RS08540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4Z98_RS08545	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E4Z98_RS08555	COG1692	metallophosphoesterase
E4Z98_RS08560	COG1263	PTS System
E4Z98_RS08560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4Z98_RS08560	COG2190	(PTS) system
E4Z98_RS08565	COG3711	transcriptional antiterminator
E4Z98_RS08570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E4Z98_RS08575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4Z98_RS08580	COG1177	transmembrane transport
E4Z98_RS08585	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4Z98_RS08590	COG3842	ATPase activity
E4Z98_RS08600	COG0604	alcohol dehydrogenase
E4Z98_RS08605	COG0628	permease
E4Z98_RS08610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4Z98_RS08610	COG3711	transcriptional antiterminator
E4Z98_RS08615	COG0802	atpase or kinase
E4Z98_RS08620	COG0280	phosphate acetyltransferase
E4Z98_RS08630	COG0561	phosphatase activity
E4Z98_RS08640	COG0142	geranyltranstransferase activity
E4Z98_RS08645	COG1266	CAAX protease self-immunity
E4Z98_RS08650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E4Z98_RS08655	COG4988	ABC transporter
E4Z98_RS08660	COG1294	oxidase, subunit
E4Z98_RS08665	COG1271	oxidase subunit
E4Z98_RS08670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4Z98_RS08680	COG0542	response to heat
E4Z98_RS08685	COG4463	regulation of RNA biosynthetic process
E4Z98_RS08690	COG0494	nUDIX hydrolase
E4Z98_RS08700	COG3964	amidohydrolase
E4Z98_RS08715	COG3964	amidohydrolase
E4Z98_RS08750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4Z98_RS08755	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4Z98_RS08760	COG0517	IMP dehydrogenase activity
E4Z98_RS08765	COG0574	Belongs to the PEP-utilizing enzyme family
E4Z98_RS08765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4Z98_RS08770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4Z98_RS08770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4Z98_RS08770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4Z98_RS08775	COG1105	Belongs to the carbohydrate kinase PfkB family
E4Z98_RS08780	COG1349	DNA-binding transcription factor activity
E4Z98_RS08800	COG3158	transport of potassium into the cell
E4Z98_RS08810	COG2964	Protein conserved in bacteria
E4Z98_RS08815	COG1823	symporter activity
E4Z98_RS08820	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4Z98_RS08825	COG0251	oxidation-reduction process
E4Z98_RS08830	COG0626	cystathionine gamma-synthase activity
E4Z98_RS08845	COG3158	transport of potassium into the cell
E4Z98_RS08850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E4Z98_RS08855	COG3959	Transketolase, thiamine diphosphate binding domain
E4Z98_RS08860	COG1461	Dihydroxyacetone kinase
E4Z98_RS08875	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E4Z98_RS08880	COG0149	triose-phosphate isomerase activity
E4Z98_RS08885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E4Z98_RS08890	COG0698	ribose 5-phosphate isomerase
E4Z98_RS08895	COG1349	DNA-binding transcription factor activity
E4Z98_RS08900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E4Z98_RS08905	COG2376	Dihydroxyacetone kinase
E4Z98_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
E4Z98_RS08990	COG1136	(ABC) transporter
E4Z98_RS08995	COG0577	efflux transmembrane transporter activity
E4Z98_RS09105	COG1388	LysM domain
E4Z98_RS09105	COG1705	Flagellar rod assembly protein muramidase FlgJ
E4Z98_RS09110	COG3584	3D domain protein
E4Z98_RS09110	COG1388	LysM domain
E4Z98_RS09190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4Z98_RS09195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E4Z98_RS09210	COG1122	ATPase activity
E4Z98_RS09215	COG1122	ATPase activity
E4Z98_RS09220	COG0203	ribosomal protein L17
E4Z98_RS09225	COG0202	RNA polymerase activity
E4Z98_RS09230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4Z98_RS09235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E4Z98_RS09240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4Z98_RS09250	COG0563	adenylate kinase activity
E4Z98_RS09255	COG0201	protein transport
E4Z98_RS09260	COG0200	Binds to the 23S rRNA
E4Z98_RS09265	COG1841	ribosomal large subunit assembly
E4Z98_RS09270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E4Z98_RS09275	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E4Z98_RS09280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E4Z98_RS09285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E4Z98_RS09290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E4Z98_RS09295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E4Z98_RS09300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E4Z98_RS09305	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E4Z98_RS09310	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E4Z98_RS09315	COG0255	Belongs to the universal ribosomal protein uL29 family
E4Z98_RS09320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E4Z98_RS09325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E4Z98_RS09330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E4Z98_RS09340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E4Z98_RS09345	COG0089	rRNA binding
E4Z98_RS09350	COG0088	Forms part of the polypeptide exit tunnel
E4Z98_RS09355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E4Z98_RS09360	COG0051	transcription antitermination factor activity, RNA binding
E4Z98_RS09370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E4Z98_RS09375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4Z98_RS09380	COG0049	tRNA binding
E4Z98_RS09385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E4Z98_RS09390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E4Z98_RS09395	COG0588	phosphoglycerate mutase activity
E4Z98_RS09415	COG1696	Membrane protein involved in D-alanine export
E4Z98_RS09420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4Z98_RS09425	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E4Z98_RS09430	COG1979	alcohol dehydrogenase
E4Z98_RS09435	COG1132	(ABC) transporter
E4Z98_RS09440	COG1278	Cold shock
E4Z98_RS09450	COG0813	purine-nucleoside phosphorylase activity
E4Z98_RS09455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E4Z98_RS09460	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E4Z98_RS09465	COG1079	Belongs to the binding-protein-dependent transport system permease family
E4Z98_RS09470	COG4603	Belongs to the binding-protein-dependent transport system permease family
E4Z98_RS09475	COG3845	ABC transporter
E4Z98_RS09480	COG1744	ABC transporter substrate-binding protein PnrA-like
E4Z98_RS09490	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E4Z98_RS09495	COG1609	Transcriptional regulator
E4Z98_RS09500	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E4Z98_RS09500	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E4Z98_RS09570	COG0791	NLP P60 protein
E4Z98_RS09570	COG0741	lytic transglycosylase activity
E4Z98_RS09625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4Z98_RS09635	COG1192	Involved in chromosome partitioning
E4Z98_RS09680	COG0484	heat shock protein binding