locus-tag	class	description
G7081_RS00010	COG0768	penicillin binding
G7081_RS00025	COG2001	Belongs to the MraZ family
G7081_RS00045	COG0497	DNA recombination
G7081_RS00055	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G7081_RS00065	COG1722	exodeoxyribonuclease VII activity
G7081_RS00070	COG1570	exodeoxyribonuclease VII activity
G7081_RS00075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G7081_RS00080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7081_RS00085	COG1302	Protein conserved in bacteria
G7081_RS00090	COG0006	proline dipeptidase activity
G7081_RS00095	COG1053	succinate dehydrogenase
G7081_RS00145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G7081_RS00150	COG1309	transcriptional regulator
G7081_RS00170	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G7081_RS00180	COG2723	6-phospho-beta-galactosidase activity
G7081_RS00185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G7081_RS00200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G7081_RS00205	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
G7081_RS00205	COG3933	PFAM sigma-54 factor interaction domain-containing protein
G7081_RS00215	COG4122	O-methyltransferase activity
G7081_RS00225	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G7081_RS00230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G7081_RS00235	COG0544	peptidyl-prolyl cis-trans isomerase activity
G7081_RS00245	COG4703	Protein of unknown function (DUF1797)
G7081_RS00250	COG2084	Dehydrogenase
G7081_RS00260	COG0438	transferase activity, transferring glycosyl groups
G7081_RS00270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7081_RS00275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7081_RS00290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G7081_RS00295	COG1253	flavin adenine dinucleotide binding
G7081_RS00300	COG0628	permease
G7081_RS00305	COG3557	Belongs to the UPF0374 family
G7081_RS00310	COG1194	a g-specific adenine glycosylase
G7081_RS00315	COG2137	regulation of response to DNA damage stimulus
G7081_RS00320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G7081_RS00340	COG1316	TRANSCRIPTIONal
G7081_RS00345	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G7081_RS00350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G7081_RS00355	COG1682	transport, permease protein
G7081_RS00370	COG1134	teichoic acid transport
G7081_RS00375	COG1316	TRANSCRIPTIONal
G7081_RS00380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G7081_RS00385	COG1295	ribonuclease BN
G7081_RS00390	COG0024	Methionine aminopeptidase
G7081_RS00395	COG0716	FMN binding
G7081_RS00415	COG3620	sequence-specific DNA binding
G7081_RS00445	COG3842	ATPase activity
G7081_RS00475	COG1196	nuclear chromosome segregation
G7081_RS00485	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
G7081_RS00495	COG1129	ABC transporter
G7081_RS00510	COG2971	BadF BadG BcrA BcrD
G7081_RS00525	COG0513	Belongs to the DEAD box helicase family
G7081_RS00530	COG0673	inositol 2-dehydrogenase activity
G7081_RS00545	COG2814	Major facilitator Superfamily
G7081_RS00555	COG1482	cell wall glycoprotein biosynthetic process
G7081_RS00560	COG3158	transport of potassium into the cell
G7081_RS00565	COG4485	Bacterial membrane protein, YfhO
G7081_RS00570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7081_RS00575	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G7081_RS00585	COG0392	lysyltransferase activity
G7081_RS00585	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G7081_RS00590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G7081_RS00595	COG0803	Belongs to the bacterial solute-binding protein 9 family
G7081_RS00600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G7081_RS00605	COG1121	(ABC) transporter
G7081_RS00610	COG3118	belongs to the thioredoxin family
G7081_RS00615	COG1193	negative regulation of DNA recombination
G7081_RS00630	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G7081_RS00635	COG3906	Belongs to the UPF0473 family
G7081_RS00640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G7081_RS00645	COG4472	Bacterial protein of unknown function (DUF965)
G7081_RS00650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7081_RS00660	COG0537	adenosine 5'-monophosphoramidase activity
G7081_RS00665	COG1131	(ABC) transporter
G7081_RS00680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G7081_RS00695	COG1363	Peptidase, m42
G7081_RS00700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7081_RS00705	COG0589	response to stress
G7081_RS00710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7081_RS00725	COG4717	serine-type aminopeptidase activity
G7081_RS00735	COG3679	Belongs to the UPF0342 family
G7081_RS00740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7081_RS00745	COG0564	pseudouridine synthase activity
G7081_RS00750	COG1438	arginine binding
G7081_RS00755	COG0018	arginyl-trna synthetase
G7081_RS00765	COG1597	lipid kinase activity
G7081_RS00770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G7081_RS00780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G7081_RS00785	COG0500	methyltransferase
G7081_RS00790	COG3142	Participates in the control of copper homeostasis
G7081_RS00795	COG2239	Acts as a magnesium transporter
G7081_RS00800	COG0564	pseudouridine synthase activity
G7081_RS00805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G7081_RS00810	COG2357	RelA SpoT domain protein
G7081_RS00845	COG0459	protein refolding
G7081_RS00850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G7081_RS00860	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G7081_RS00865	COG0488	(ABC) transporter
G7081_RS00870	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G7081_RS00875	COG4109	DRTGG domain
G7081_RS00885	COG1132	(ABC) transporter
G7081_RS00900	COG1575	Belongs to the MenA family. Type 1 subfamily
G7081_RS00905	COG3425	synthase
G7081_RS00910	COG0183	Belongs to the thiolase family
G7081_RS00925	COG3104	oligopeptide transport
G7081_RS00940	COG3715	PTS system
G7081_RS00945	COG3716	PTS system mannose fructose sorbose family IID component
G7081_RS00965	COG2814	Major facilitator Superfamily
G7081_RS00970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G7081_RS00975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G7081_RS00990	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G7081_RS00995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7081_RS01000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G7081_RS01015	COG5002	protein histidine kinase activity
G7081_RS01020	COG0745	RESPONSE REGULATOR receiver
G7081_RS01025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G7081_RS01030	COG3973	AAA domain
G7081_RS01040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G7081_RS01045	COG0783	Belongs to the Dps family
G7081_RS01055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G7081_RS01060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G7081_RS01065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G7081_RS01070	COG1011	Hydrolase
G7081_RS01075	COG4862	establishment of competence for transformation
G7081_RS01080	COG1393	Belongs to the ArsC family
G7081_RS01085	COG0180	Tryptophanyl-tRNA synthetase
G7081_RS01090	COG0740	serine-type endopeptidase activity
G7081_RS01100	COG0095	Lipoate-protein ligase
G7081_RS01105	COG1363	Peptidase, m42
G7081_RS01110	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
G7081_RS01115	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
G7081_RS01120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7081_RS01125	COG1696	Membrane protein involved in D-alanine export
G7081_RS01140	COG0602	queuosine metabolic process
G7081_RS01155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G7081_RS01160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G7081_RS01165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G7081_RS01170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G7081_RS01175	COG1185	polyribonucleotide nucleotidyltransferase activity
G7081_RS01185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G7081_RS01190	COG0242	peptide deformylase activity
G7081_RS01215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G7081_RS01230	COG1459	type II secretion system
G7081_RS01260	COG3942	CHAP domain
G7081_RS01260	COG1705	Flagellar rod assembly protein muramidase FlgJ
G7081_RS01270	COG0681	Belongs to the peptidase S26 family
G7081_RS01285	COG0561	phosphatase activity
G7081_RS01290	COG1346	cytolysis
G7081_RS01295	COG1380	Effector of murein hydrolase LrgA
G7081_RS01305	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
G7081_RS01310	COG1263	PTS System
G7081_RS01310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7081_RS01320	COG1737	Transcriptional regulator
G7081_RS01325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G7081_RS01350	COG4537	Required for transformation and DNA binding
G7081_RS01355	COG1459	type II secretion system
G7081_RS01360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G7081_RS01380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G7081_RS01390	COG1396	sequence-specific DNA binding
G7081_RS01395	COG2813	Specifically methylates the guanine in position
G7081_RS01400	COG2755	lipolytic protein G-D-S-L family
G7081_RS01405	COG1072	(Pantothenic acid kinase))
G7081_RS01410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G7081_RS01410	COG0519	Catalyzes the synthesis of GMP from XMP
G7081_RS01435	COG0842	Transport permease protein
G7081_RS01440	COG1131	(ABC) transporter
G7081_RS01455	COG4886	Leucine-rich repeat (LRR) protein
G7081_RS01455	COG4932	domain protein
G7081_RS01480	COG5646	InterPro IPR014922
G7081_RS01500	COG1395	domain, Protein
G7081_RS01515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G7081_RS01545	COG0739	heme binding
G7081_RS01545	COG0741	lytic transglycosylase activity
G7081_RS01545	COG1196	nuclear chromosome segregation
G7081_RS01550	COG0745	RESPONSE REGULATOR receiver
G7081_RS01555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G7081_RS01560	COG0517	IMP dehydrogenase activity
G7081_RS01565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7081_RS01565	COG0574	Belongs to the PEP-utilizing enzyme family
G7081_RS01585	COG1307	EDD domain protein, DegV family
G7081_RS01590	COG0039	L-malate dehydrogenase activity
G7081_RS01595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7081_RS01600	COG0156	8-amino-7-oxononanoate synthase activity
G7081_RS01610	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G7081_RS01615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G7081_RS01620	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
G7081_RS01625	COG0084	hydrolase, TatD family'
G7081_RS01630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7081_RS01630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7081_RS01635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G7081_RS01640	COG0322	excinuclease ABC activity
G7081_RS01645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G7081_RS01660	COG1792	Involved in formation and maintenance of cell shape
G7081_RS01665	COG1454	alcohol dehydrogenase
G7081_RS01665	COG1012	belongs to the aldehyde dehydrogenase family
G7081_RS01675	COG1862	Preprotein translocase
G7081_RS01680	COG0343	queuine tRNA-ribosyltransferase activity
G7081_RS01685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G7081_RS01690	COG2255	four-way junction helicase activity
G7081_RS01700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G7081_RS01705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G7081_RS01715	COG1692	metallophosphoesterase
G7081_RS01720	COG1418	mRNA catabolic process
G7081_RS01725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G7081_RS01730	COG1058	Belongs to the CinA family
G7081_RS01730	COG1546	Belongs to the CinA family
G7081_RS01735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G7081_RS01740	COG1426	Protein conserved in bacteria
G7081_RS01745	COG0612	Peptidase, M16
G7081_RS01750	COG0612	Peptidase, M16
G7081_RS01755	COG1970	mechanosensitive ion channel activity
G7081_RS01760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G7081_RS01765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G7081_RS01770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G7081_RS01775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G7081_RS01780	COG1121	(ABC) transporter
G7081_RS01785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G7081_RS01790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G7081_RS01800	COG1176	ABC-type spermidine putrescine transport system, permease component I
G7081_RS01805	COG3842	ATPase activity
G7081_RS01810	COG3800	Transcriptional regulator
G7081_RS01810	COG1396	sequence-specific DNA binding
G7081_RS01815	COG0604	alcohol dehydrogenase
G7081_RS01820	COG4684	Psort location CytoplasmicMembrane, score
G7081_RS01830	COG4975	Glucose uptake
G7081_RS01835	COG1869	D-ribose catabolic process
G7081_RS01845	COG1609	Transcriptional regulator
G7081_RS01850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G7081_RS01855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G7081_RS01870	COG1122	ATPase activity
G7081_RS01875	COG1122	ATPase activity
G7081_RS01880	COG0203	ribosomal protein L17
G7081_RS01885	COG0202	RNA polymerase activity
G7081_RS01890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G7081_RS01895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G7081_RS01900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G7081_RS01905	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G7081_RS01910	COG0563	adenylate kinase activity
G7081_RS01920	COG0200	Binds to the 23S rRNA
G7081_RS01925	COG1841	ribosomal large subunit assembly
G7081_RS01930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G7081_RS01935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G7081_RS01940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G7081_RS01945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G7081_RS01950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G7081_RS01955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G7081_RS01960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G7081_RS01965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G7081_RS01970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G7081_RS01975	COG0255	Belongs to the universal ribosomal protein uL29 family
G7081_RS01980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G7081_RS01985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G7081_RS01990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G7081_RS01995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G7081_RS02000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G7081_RS02005	COG0089	rRNA binding
G7081_RS02010	COG0088	Forms part of the polypeptide exit tunnel
G7081_RS02015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G7081_RS02020	COG0051	transcription antitermination factor activity, RNA binding
G7081_RS02025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G7081_RS02030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G7081_RS02035	COG0049	tRNA binding
G7081_RS02040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G7081_RS02045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G7081_RS02050	COG2116	formate transmembrane transporter activity
G7081_RS02055	COG0588	phosphoglycerate mutase activity
G7081_RS02060	COG1979	alcohol dehydrogenase
G7081_RS02065	COG0813	purine-nucleoside phosphorylase activity
G7081_RS02070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G7081_RS02075	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
G7081_RS02095	COG1744	ABC transporter substrate-binding protein PnrA-like
G7081_RS02105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G7081_RS02110	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
G7081_RS02115	COG1609	Transcriptional regulator
G7081_RS02130	COG4939	FMN-binding domain protein
G7081_RS02150	COG0561	phosphatase activity
G7081_RS02155	COG0488	(ABC) transporter
G7081_RS02160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G7081_RS02165	COG0305	Participates in initiation and elongation during chromosome replication
G7081_RS02170	COG0359	binds to the 23S rRNA
G7081_RS02175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G7081_RS02180	COG0629	single-stranded DNA binding
G7081_RS02185	COG0360	Binds together with S18 to 16S ribosomal RNA
G7081_RS02195	COG0187	DNA topoisomerase II activity
G7081_RS02200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G7081_RS02210	COG0592	DNA-directed DNA polymerase activity
G7081_RS02215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G7081_RS02225	COG0594	ribonuclease P activity
G7081_RS02230	COG0706	membrane insertase activity
G7081_RS02245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G7081_RS02250	COG0445	tRNA wobble uridine modification
G7081_RS02255	COG0357	Ribosomal RNA small subunit methyltransferase G
G7081_RS02260	COG1192	Involved in chromosome partitioning
G7081_RS02265	COG1475	DNA binding
G7081_RS02270	COG4481	Protein conserved in bacteria
G7081_RS02275	COG0012	GTP binding
G7081_RS02285	COG0517	IMP dehydrogenase activity
G7081_RS02285	COG0516	GMP reductase activity
G7081_RS02290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G7081_RS02295	COG1686	Belongs to the peptidase S11 family
G7081_RS02370	COG4463	regulation of RNA biosynthetic process
G7081_RS02375	COG0542	response to heat
G7081_RS02390	COG1271	oxidase subunit
G7081_RS02395	COG1294	oxidase, subunit
G7081_RS02400	COG4988	ABC transporter
G7081_RS02405	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G7081_RS02420	COG2217	Heavy metal translocating P-type atpase
G7081_RS02435	COG0456	acetyltransferase
G7081_RS02445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G7081_RS02460	COG0561	phosphatase activity
G7081_RS02465	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G7081_RS02470	COG0280	phosphate acetyltransferase
G7081_RS02475	COG0802	atpase or kinase
G7081_RS02490	COG0708	Exodeoxyribonuclease III
G7081_RS02500	COG1132	(ABC) transporter
G7081_RS02510	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G7081_RS02520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G7081_RS02525	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G7081_RS02525	COG1605	Chorismate mutase
G7081_RS02535	COG0193	aminoacyl-tRNA hydrolase activity
G7081_RS02540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G7081_RS02545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G7081_RS02555	COG1098	S1 RNA binding domain
G7081_RS02560	COG0037	tRNA processing
G7081_RS02570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7081_RS02575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G7081_RS02580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G7081_RS02585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G7081_RS02730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G7081_RS02735	COG0477	Major facilitator Superfamily
G7081_RS02740	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
G7081_RS02745	COG1242	4 iron, 4 sulfur cluster binding
G7081_RS02750	COG0671	phosphoesterase, PA-phosphatase related
G7081_RS02765	COG0495	leucyl-tRNA aminoacylation
G7081_RS02770	COG2244	polysaccharide biosynthetic process
G7081_RS02775	COG1187	pseudouridine synthase activity
G7081_RS02785	COG2309	aminopeptidase activity
G7081_RS02790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7081_RS02800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G7081_RS02810	COG0250	Participates in transcription elongation, termination and antitermination
G7081_RS02815	COG1760	l-serine dehydratase
G7081_RS02820	COG1760	l-serine dehydratase
G7081_RS02825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G7081_RS02830	COG0081	regulation of translation
G7081_RS02835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G7081_RS02840	COG0222	ribosome binding
G7081_RS02845	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G7081_RS02850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G7081_RS02855	COG0037	tRNA processing
G7081_RS02875	COG1187	pseudouridine synthase activity
G7081_RS02880	COG0572	uridine kinase
G7081_RS02890	COG5506	Protein of unknown function (DUF1694)
G7081_RS02895	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7081_RS02900	COG4605	iron ion homeostasis
G7081_RS02905	COG4604	ABC transporter, ATP-binding protein
G7081_RS02910	COG4607	ABC-type enterochelin transport system periplasmic component
G7081_RS02915	COG4493	Belongs to the UPF0637 family
G7081_RS02920	COG0827	DNA restriction-modification system
G7081_RS02925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G7081_RS02930	COG0589	response to stress
G7081_RS02945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G7081_RS02955	COG2264	protein methyltransferase activity
G7081_RS02960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G7081_RS02965	COG1012	belongs to the aldehyde dehydrogenase family
G7081_RS02970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G7081_RS02975	COG1490	D-aminoacyl-tRNA deacylase activity
G7081_RS02980	COG0860	N-Acetylmuramoyl-L-alanine amidase
G7081_RS02980	COG3103	Sh3 type 3 domain protein
G7081_RS02980	COG4991	sh3 domain protein
G7081_RS02985	COG0124	histidyl-tRNA synthetase
G7081_RS02990	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G7081_RS02995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G7081_RS03000	COG2827	Endonuclease containing a URI domain
G7081_RS03005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G7081_RS03010	COG0204	Acyl-transferase
G7081_RS03015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G7081_RS03020	COG1132	(ABC) transporter
G7081_RS03025	COG1363	Peptidase, m42
G7081_RS03030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G7081_RS03035	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7081_RS03040	COG1937	Protein conserved in bacteria
G7081_RS03050	COG0756	dUTP diphosphatase activity
G7081_RS03060	COG4956	integral membrane protein (PIN domain superfamily)
G7081_RS03065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G7081_RS03070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7081_RS03075	COG0215	cysteine-tRNA ligase activity
G7081_RS03080	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G7081_RS03085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7081_RS03095	COG4466	Protein conserved in bacteria
G7081_RS03100	COG1671	Belongs to the UPF0178 family
G7081_RS03105	COG3764	Sortase (surface protein transpeptidase)
G7081_RS03115	COG1181	Belongs to the D-alanine--D-alanine ligase family
G7081_RS03120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G7081_RS03130	COG0736	holo-[acyl-carrier-protein] synthase activity
G7081_RS03150	COG0194	GDP metabolic process
G7081_RS03160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G7081_RS03170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G7081_RS03175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G7081_RS03175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7081_RS03185	COG2815	serine threonine protein kinase
G7081_RS03185	COG0515	serine threonine protein kinase
G7081_RS03190	COG1162	GTPase activity
G7081_RS03195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G7081_RS03200	COG1564	THIamine pyrophosphokinase
G7081_RS03205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G7081_RS03215	COG1461	Dihydroxyacetone kinase
G7081_RS03225	COG3448	diguanylate cyclase activity
G7081_RS03225	COG4175	Glycine betaine
G7081_RS03235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G7081_RS03240	COG0416	fatty acid biosynthetic process
G7081_RS03255	COG4608	Belongs to the ABC transporter superfamily
G7081_RS03260	COG0601	transmembrane transport
G7081_RS03275	COG1027	Aspartate ammonia-lyase
G7081_RS03280	COG0114	fumarate hydratase activity
G7081_RS03285	COG0626	cystathionine gamma-synthase activity
G7081_RS03290	COG0571	ribonuclease III activity
G7081_RS03295	COG1196	nuclear chromosome segregation
G7081_RS03300	COG0561	phosphatase activity
G7081_RS03305	COG0552	protein localization to endoplasmic reticulum
G7081_RS03310	COG1181	Belongs to the D-alanine--D-alanine ligase family
G7081_RS03310	COG2918	glutathione biosynthetic process
G7081_RS03325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G7081_RS03330	COG1335	isochorismatase
G7081_RS03335	COG2376	Dihydroxyacetone kinase
G7081_RS03340	COG1461	Dihydroxyacetone kinase
G7081_RS03345	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
G7081_RS03355	COG2376	Dihydroxyacetone kinase
G7081_RS03360	COG1309	transcriptional regulator
G7081_RS03365	COG1104	cysteine desulfurase activity
G7081_RS03380	COG0482	sulfurtransferase activity
G7081_RS03390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G7081_RS03395	COG2153	protein acetylation
G7081_RS03405	COG0719	Fe-S assembly protein
G7081_RS03410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G7081_RS03440	COG0464	growth
G7081_RS03475	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G7081_RS03480	COG0596	Alpha beta hydrolase
G7081_RS03485	COG0384	phenazine biosynthesis protein PhzF
G7081_RS03505	COG4335	DNA alkylation repair
G7081_RS03520	COG0778	Nitroreductase
G7081_RS03560	COG4932	domain protein
G7081_RS03560	COG4886	Leucine-rich repeat (LRR) protein
G7081_RS03575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G7081_RS03580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G7081_RS03590	COG0640	Transcriptional regulator
G7081_RS03610	COG0765	amino acid transport
G7081_RS03615	COG1126	abc transporter atp-binding protein
G7081_RS03630	COG1473	amidohydrolase
G7081_RS03635	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
G7081_RS03655	COG0833	amino acid
G7081_RS03660	COG0420	3'-5' exonuclease activity
G7081_RS03665	COG0419	ATPase involved in DNA repair
G7081_RS03675	COG1297	OPT oligopeptide transporter protein
G7081_RS03690	COG3201	nicotinamide mononucleotide transporter
G7081_RS03695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G7081_RS03705	COG0701	Predicted permease
G7081_RS03710	COG3689	TIGRFAM TIGR03943 family protein
G7081_RS03735	COG0513	Belongs to the DEAD box helicase family
G7081_RS03770	COG0745	RESPONSE REGULATOR receiver
G7081_RS03775	COG3850	Histidine kinase
G7081_RS03775	COG5002	protein histidine kinase activity
G7081_RS03780	COG4476	Belongs to the UPF0223 family
G7081_RS03795	COG0210	DNA helicase
G7081_RS03800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G7081_RS03805	COG4851	CamS sex pheromone cAM373 precursor
G7081_RS03810	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G7081_RS03815	COG0154	amidase activity
G7081_RS03820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G7081_RS03825	COG1597	lipid kinase activity
G7081_RS03830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G7081_RS03835	COG1368	sulfuric ester hydrolase activity
G7081_RS03840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G7081_RS03845	COG0710	3-dehydroquinate dehydratase activity
G7081_RS03850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G7081_RS03860	COG2081	HI0933 family
G7081_RS03865	COG0166	Belongs to the GPI family
G7081_RS03870	COG2249	NAD(P)H dehydrogenase (quinone) activity
G7081_RS03885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G7081_RS03890	COG0768	penicillin binding
G7081_RS03900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G7081_RS03905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G7081_RS03960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G7081_RS03965	COG3442	glutamine amidotransferase
G7081_RS03970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G7081_RS03975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G7081_RS03985	COG1435	thymidine kinase activity
G7081_RS03990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G7081_RS03995	COG2890	protein-(glutamine-N5) methyltransferase activity
G7081_RS04000	COG0009	L-threonylcarbamoyladenylate synthase
G7081_RS04005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G7081_RS04010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G7081_RS04015	COG0726	polysaccharide deacetylase
G7081_RS04025	COG0772	Belongs to the SEDS family
G7081_RS04030	COG1393	Belongs to the ArsC family
G7081_RS04035	COG0509	glycine decarboxylation via glycine cleavage system
G7081_RS04045	COG1280	lysine exporter protein (LysE YggA)
G7081_RS04045	COG1674	ftsk spoiiie
G7081_RS04050	COG0025	NhaP-type Na H and K H
G7081_RS04060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G7081_RS04075	COG1078	dGTPase activity
G7081_RS04080	COG0095	Lipoate-protein ligase
G7081_RS04095	COG1555	photosystem II stabilization
G7081_RS04095	COG1596	polysaccharide export
G7081_RS04100	COG2131	deaminase
G7081_RS04105	COG2333	competence protein COMEC
G7081_RS04105	COG0658	competence protein
G7081_RS04110	COG1466	dna polymerase III delta subunit
G7081_RS04115	COG0268	Binds directly to 16S ribosomal RNA
G7081_RS04120	COG0306	phosphate transporter
G7081_RS04125	COG1968	undecaprenyl-diphosphatase activity
G7081_RS04135	COG0789	Transcriptional regulator
G7081_RS04145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G7081_RS04150	COG2252	PERMEase
G7081_RS04155	COG1285	pathogenesis
G7081_RS04160	COG2365	Tyrosine phosphatase family
G7081_RS04165	COG4470	Protein conserved in bacteria
G7081_RS04170	COG0647	UMP catabolic process
G7081_RS04180	COG0492	ferredoxin-NADP+ reductase activity
G7081_RS04190	COG1098	S1 RNA binding domain
G7081_RS04225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G7081_RS04230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G7081_RS04240	COG4585	Histidine kinase
G7081_RS04245	COG2197	response regulator
G7081_RS04250	COG0569	domain protein
G7081_RS04255	COG4841	protein insertion into membrane
G7081_RS04265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G7081_RS04270	COG4838	Belongs to the UPF0358 family
G7081_RS04275	COG0772	Belongs to the SEDS family
G7081_RS04290	COG4471	UPF0298 protein
G7081_RS04295	COG0742	ribosomal rna small subunit methyltransferase
G7081_RS04300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G7081_RS04305	COG3480	Lon protease (S16) C-terminal proteolytic domain
G7081_RS04310	COG0191	fructose-bisphosphate aldolase activity
G7081_RS04315	COG1959	2 iron, 2 sulfur cluster binding
G7081_RS04325	COG2706	6-phosphogluconolactonase activity
G7081_RS04330	COG0628	permease
G7081_RS04335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G7081_RS04345	COG3706	GGDEF domain
G7081_RS04355	COG2824	Alkylphosphonate utilization operon protein PhnA
G7081_RS04360	COG2738	Putative neutral zinc metallopeptidase
G7081_RS04365	COG0590	tRNA wobble adenosine to inosine editing
G7081_RS04375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G7081_RS04380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G7081_RS04385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G7081_RS04395	COG3870	Protein conserved in bacteria
G7081_RS04400	COG0470	DNA polymerase III
G7081_RS04405	COG1774	PSP1 C-terminal conserved region
G7081_RS04410	COG4467	Involved in initiation control of chromosome replication
G7081_RS04415	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G7081_RS04420	COG0531	amino acid
G7081_RS04435	COG1132	(ABC) transporter
G7081_RS04440	COG2514	catechol 2,3-dioxygenase activity
G7081_RS04445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G7081_RS04450	COG0254	rRNA binding
G7081_RS04455	COG0737	Belongs to the 5'-nucleotidase family
G7081_RS04465	COG2814	Major facilitator Superfamily
G7081_RS04490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7081_RS04495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G7081_RS04500	COG4807	Protein conserved in bacteria
G7081_RS04505	COG2321	neutral zinc metallopeptidase
G7081_RS04510	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
G7081_RS04515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G7081_RS04520	COG1534	Rna-binding protein
G7081_RS04525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G7081_RS04530	COG1713	HD superfamily hydrolase involved in NAD metabolism
G7081_RS04535	COG0799	negative regulation of ribosome biogenesis
G7081_RS04540	COG2226	methyltransferase
G7081_RS04550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
G7081_RS04560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G7081_RS04565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G7081_RS04570	COG0363	glucosamine-6-phosphate deaminase activity
G7081_RS04575	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
G7081_RS04580	COG1214	PFAM Peptidase M22, glycoprotease
G7081_RS04595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G7081_RS04600	COG0052	Belongs to the universal ribosomal protein uS2 family
G7081_RS04605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G7081_RS04610	COG0528	UMP kinase activity
G7081_RS04615	COG0233	cytoplasmic translational termination
G7081_RS04620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G7081_RS04625	COG4589	Belongs to the CDS family
G7081_RS04630	COG0750	zinc metalloprotease
G7081_RS04635	COG0442	prolyl-tRNA aminoacylation
G7081_RS04650	COG0779	Required for maturation of 30S ribosomal subunits
G7081_RS04655	COG0195	Participates in both transcription termination and antitermination
G7081_RS04660	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G7081_RS04670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G7081_RS04675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G7081_RS04680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G7081_RS04685	COG0196	riboflavin kinase activity
G7081_RS04690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G7081_RS04695	COG1288	antiporter activity
G7081_RS04700	COG1420	regulation of RNA biosynthetic process
G7081_RS04705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G7081_RS04710	COG0443	Heat shock 70 kDa protein
G7081_RS04715	COG0484	heat shock protein binding
G7081_RS04720	COG0803	Belongs to the bacterial solute-binding protein 9 family
G7081_RS04725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G7081_RS04740	COG0513	Belongs to the DEAD box helicase family
G7081_RS04755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G7081_RS04765	COG0561	phosphatase activity
G7081_RS04775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G7081_RS04785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G7081_RS04785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G7081_RS04790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G7081_RS04795	COG0237	dephospho-CoA kinase activity
G7081_RS04800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G7081_RS04810	COG1484	DNA-dependent DNA replication
G7081_RS04820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G7081_RS04825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G7081_RS04830	COG0745	RESPONSE REGULATOR receiver
G7081_RS04835	COG5002	protein histidine kinase activity
G7081_RS04840	COG0306	phosphate transporter
G7081_RS04845	COG1392	Phosphate transport regulator
G7081_RS04855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7081_RS04865	COG1733	regulation of RNA biosynthetic process
G7081_RS04870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G7081_RS04875	COG0072	phenylalanine-tRNA ligase activity
G7081_RS04875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7081_RS04890	COG2076	Multidrug Resistance protein
G7081_RS04895	COG2076	Multidrug Resistance protein
G7081_RS04900	COG2910	NAD(P)H-binding
G7081_RS04920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G7081_RS04930	COG0584	glycerophosphoryl diester phosphodiesterase
G7081_RS04935	COG1304	FMN binding
G7081_RS04950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G7081_RS04955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G7081_RS04965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G7081_RS04970	COG1234	tRNA 3'-trailer cleavage
G7081_RS04975	COG5416	Lipopolysaccharide assembly protein A domain
G7081_RS04980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G7081_RS04980	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G7081_RS04985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G7081_RS04990	COG0745	RESPONSE REGULATOR receiver
G7081_RS04995	COG5002	protein histidine kinase activity
G7081_RS05000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G7081_RS05005	COG0573	inorganic phosphate transmembrane transporter activity
G7081_RS05010	COG0581	inorganic phosphate transmembrane transporter activity
G7081_RS05015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G7081_RS05020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G7081_RS05025	COG0704	Plays a role in the regulation of phosphate uptake
G7081_RS05030	COG0861	Integral membrane protein TerC family
G7081_RS05045	COG0741	lytic transglycosylase activity
G7081_RS05050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G7081_RS05055	COG3935	DnaD domain protein
G7081_RS05060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G7081_RS05065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7081_RS05070	COG3331	DNA recombination
G7081_RS05075	COG4474	Belongs to the UPF0398 family
G7081_RS05090	COG0116	Belongs to the methyltransferase superfamily
G7081_RS05100	COG0328	RNA-DNA hybrid ribonuclease activity
G7081_RS05110	COG1278	Cold shock
G7081_RS05120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G7081_RS05125	COG0564	pseudouridine synthase activity
G7081_RS05135	COG2233	PERMEase
G7081_RS05145	COG0038	chloride channel
G7081_RS05150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G7081_RS05155	COG1120	ATPase activity
G7081_RS05165	COG0477	Major facilitator Superfamily
G7081_RS05170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G7081_RS05170	COG1199	ATP-dependent helicase activity
G7081_RS05180	COG0017	Asparaginyl-tRNA synthetase
G7081_RS05185	COG1073	alpha beta
G7081_RS05190	COG0778	Nitroreductase
G7081_RS05195	COG0393	Putative heavy-metal-binding
G7081_RS05200	COG3682	Transcriptional regulator
G7081_RS05205	COG2608	mercury ion transmembrane transporter activity
G7081_RS05210	COG2217	Heavy metal translocating P-type atpase
G7081_RS05215	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
G7081_RS05220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G7081_RS05230	COG0228	four-way junction DNA binding
G7081_RS05235	COG1837	Belongs to the UPF0109 family
G7081_RS05240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G7081_RS05245	COG0336	Belongs to the RNA methyltransferase TrmD family
G7081_RS05250	COG0335	large ribosomal subunit rRNA binding
G7081_RS05260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G7081_RS05300	COG1064	alcohol dehydrogenase
G7081_RS05305	COG2514	catechol 2,3-dioxygenase activity
G7081_RS05310	COG0662	Cupin 2, conserved barrel domain protein
G7081_RS05315	COG0433	COG0433 Predicted ATPase
G7081_RS05325	COG2188	Transcriptional regulator
G7081_RS05330	COG1131	(ABC) transporter
G7081_RS05345	COG1739	Uncharacterized protein family UPF0029
G7081_RS05355	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
G7081_RS05360	COG1040	competence protein
G7081_RS05370	COG0653	protein targeting
G7081_RS05380	COG2884	Cell division ATP-binding protein ftsE
G7081_RS05385	COG2177	Part of the ABC transporter FtsEX involved in
G7081_RS05390	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7081_RS05400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G7081_RS05420	COG1293	RNA-binding protein homologous to eukaryotic snRNP
G7081_RS05435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G7081_RS05440	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G7081_RS05450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G7081_RS05455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G7081_RS05460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G7081_RS05470	COG1307	EDD domain protein, DegV family
G7081_RS05480	COG2814	Major facilitator Superfamily
G7081_RS05490	COG0587	DNA-directed DNA polymerase activity
G7081_RS05495	COG0205	6-phosphofructokinase activity
G7081_RS05505	COG3409	Peptidoglycan-binding domain 1 protein
G7081_RS05505	COG0793	Belongs to the peptidase S41A family
G7081_RS05510	COG0681	Belongs to the peptidase S26 family
G7081_RS05520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G7081_RS05525	COG0758	DNA mediated transformation
G7081_RS05530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G7081_RS05535	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
G7081_RS05540	COG4974	Belongs to the 'phage' integrase family
G7081_RS05555	COG2807	transmembrane transport
G7081_RS05565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G7081_RS05585	COG0861	Integral membrane protein TerC family
G7081_RS05590	COG0778	Nitroreductase
G7081_RS05600	COG1666	GTP binding
G7081_RS05605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G7081_RS05610	COG2151	metal-sulfur cluster biosynthetic enzyme
G7081_RS05620	COG2996	Protein conserved in bacteria
G7081_RS05635	COG0735	belongs to the Fur family
G7081_RS05640	COG4974	Belongs to the 'phage' integrase family
G7081_RS05645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G7081_RS05650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G7081_RS05655	COG1187	pseudouridine synthase activity
G7081_RS05680	COG0514	ATP-dependent DNA helicase (RecQ)
G7081_RS05690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G7081_RS05695	COG0539	negative regulation of cytoplasmic translation
G7081_RS05700	COG1160	GTP binding
G7081_RS05710	COG0457	Tetratricopeptide repeat
G7081_RS05715	COG5582	Belongs to the UPF0302 family
G7081_RS05720	COG0617	tRNA 3'-terminal CCA addition
G7081_RS05735	COG0488	(ABC) transporter
G7081_RS05740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G7081_RS05750	COG0367	asparagine synthase
G7081_RS05755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7081_RS05765	COG1794	racemase activity, acting on amino acids and derivatives
G7081_RS05770	COG1272	protein, Hemolysin III
G7081_RS05775	COG1307	EDD domain protein, DegV family
G7081_RS05780	COG2755	lipolytic protein G-D-S-L family
G7081_RS05790	COG4479	Belongs to the UPF0346 family
G7081_RS05800	COG0628	permease
G7081_RS05805	COG2814	Major facilitator Superfamily
G7081_RS05810	COG1132	(ABC) transporter
G7081_RS05815	COG1132	(ABC) transporter
G7081_RS05820	COG3201	nicotinamide mononucleotide transporter
G7081_RS05850	COG0431	NADPH-dependent FMN reductase
G7081_RS05855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G7081_RS05860	COG1733	regulation of RNA biosynthetic process
G7081_RS05875	COG1253	flavin adenine dinucleotide binding
G7081_RS05890	COG1187	pseudouridine synthase activity
G7081_RS05900	COG1227	inorganic diphosphatase activity
G7081_RS05915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G7081_RS05920	COG1882	Formate acetyltransferase
G7081_RS05925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G7081_RS05930	COG0187	DNA topoisomerase II activity
G7081_RS05950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G7081_RS05960	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G7081_RS05970	COG2188	Transcriptional regulator
G7081_RS05975	COG1074	ATP-dependent DNA helicase activity
G7081_RS05980	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
G7081_RS06000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G7081_RS06015	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G7081_RS06020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G7081_RS06025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G7081_RS06030	COG1028	Short-chain dehydrogenase reductase Sdr
G7081_RS06055	COG0456	acetyltransferase
G7081_RS06060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G7081_RS06070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G7081_RS06080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G7081_RS06085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G7081_RS06090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G7081_RS06095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G7081_RS06100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G7081_RS06105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G7081_RS06110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G7081_RS06115	COG0356	it plays a direct role in the translocation of protons across the membrane
G7081_RS06120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G7081_RS06125	COG0557	exoribonuclease II activity
G7081_RS06130	COG1647	Serine aminopeptidase, S33
G7081_RS06135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G7081_RS06195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G7081_RS06215	COG0709	Synthesizes selenophosphate from selenide and ATP
G7081_RS06275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
G7081_RS06280	COG0149	triose-phosphate isomerase activity
G7081_RS06285	COG0126	phosphoglycerate kinase activity
G7081_RS06315	COG0740	serine-type endopeptidase activity
G7081_RS06320	COG1481	regulation of sporulation
G7081_RS06325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G7081_RS06330	COG1660	Displays ATPase and GTPase activities
G7081_RS06335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G7081_RS06340	COG0556	nucleotide-excision repair
G7081_RS06345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7081_RS06350	COG0586	Pfam SNARE associated Golgi protein
G7081_RS06355	COG0688	phosphatidylethanolamine metabolic process
G7081_RS06360	COG1183	phosphatidylcholine synthase activity
G7081_RS06365	COG0217	transcriptional regulatory protein
G7081_RS06370	COG1323	Belongs to the UPF0348 family
G7081_RS06375	COG0492	ferredoxin-NADP+ reductase activity
G7081_RS06380	COG0534	Mate efflux family protein
G7081_RS06390	COG1132	(ABC) transporter
G7081_RS06395	COG1132	(ABC) transporter
G7081_RS06400	COG3763	UPF0154 protein
G7081_RS06405	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
G7081_RS06415	COG1609	Transcriptional regulator
G7081_RS06440	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G7081_RS06455	COG1278	Cold shock
G7081_RS06540	COG0735	belongs to the Fur family
G7081_RS06555	COG1363	Peptidase, m42
G7081_RS06560	COG1363	Peptidase, m42
G7081_RS06570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G7081_RS06575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G7081_RS06580	COG1446	asparaginase
G7081_RS06585	COG1447	Phosphotransferase system cellobiose-specific component IIA
G7081_RS06590	COG2188	Transcriptional regulator
G7081_RS06595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7081_RS06600	COG1113	amino acid transport
G7081_RS06605	COG1113	amino acid transport
G7081_RS06620	COG0463	Glycosyl transferase, family 2
G7081_RS06625	COG2246	polysaccharide biosynthetic process
G7081_RS06635	COG1136	(ABC) transporter
G7081_RS06645	COG1970	mechanosensitive ion channel activity
G7081_RS06685	COG1309	transcriptional regulator
G7081_RS06735	COG2814	Major facilitator Superfamily
G7081_RS06745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G7081_RS06785	COG1263	PTS System
G7081_RS06785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7081_RS06785	COG2190	(PTS) system
G7081_RS06790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7081_RS06790	COG1263	PTS System
G7081_RS06790	COG2190	(PTS) system
G7081_RS06795	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
G7081_RS06800	COG1737	Transcriptional regulator
G7081_RS06805	COG1959	2 iron, 2 sulfur cluster binding
G7081_RS06815	COG0431	NADPH-dependent FMN reductase
G7081_RS06830	COG0488	(ABC) transporter
G7081_RS06860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G7081_RS06875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7081_RS06880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7081_RS06885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G7081_RS06900	COG0135	phosphoribosylanthranilate isomerase activity
G7081_RS06905	COG1522	sequence-specific DNA binding
G7081_RS06905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7081_RS06910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7081_RS06910	COG1522	sequence-specific DNA binding
G7081_RS06915	COG1957	nucleoside hydrolase
G7081_RS06925	COG3623	hexulose-6-phosphate isomerase
G7081_RS06965	COG1486	melibiose metabolic process
G7081_RS06980	COG2190	(PTS) system
G7081_RS06980	COG1263	PTS System
G7081_RS06980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G7081_RS06985	COG3711	transcriptional antiterminator
G7081_RS06990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G7081_RS06995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G7081_RS07000	COG1447	Phosphotransferase system cellobiose-specific component IIA
G7081_RS07015	COG1447	Phosphotransferase system cellobiose-specific component IIA
G7081_RS07020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G7081_RS07025	COG1940	carbohydrate kinase activity
G7081_RS07030	COG1486	melibiose metabolic process
G7081_RS07035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G7081_RS07040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G7081_RS07115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G7081_RS07135	COG0789	Transcriptional regulator
G7081_RS07140	COG4221	oxidoreductase activity
G7081_RS07150	COG0789	Transcriptional regulator
G7081_RS07155	COG1609	Transcriptional regulator
G7081_RS07175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G7081_RS07200	COG1686	Belongs to the peptidase S11 family
G7081_RS07210	COG0481	GTPase activity
G7081_RS07235	COG0542	response to heat
G7081_RS07245	COG2195	Cleaves the N-terminal amino acid of tripeptides
G7081_RS07250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G7081_RS07255	COG2384	SAM-dependent methyltransferase
G7081_RS07265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G7081_RS07270	COG0358	DNA primase activity
G7081_RS07275	COG0515	serine threonine protein kinase
G7081_RS07275	COG2815	serine threonine protein kinase
G7081_RS07280	COG1136	(ABC) transporter
G7081_RS07285	COG0577	efflux transmembrane transporter activity
G7081_RS07290	COG0251	oxidation-reduction process
G7081_RS07295	COG0751	glycine-tRNA ligase activity
G7081_RS07300	COG0752	glycyl-tRNA synthetase alpha subunit
G7081_RS07305	COG1381	Involved in DNA repair and RecF pathway recombination
G7081_RS07310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G7081_RS07315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G7081_RS07320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G7081_RS07330	COG1702	phosphate starvation-inducible protein PhoH
G7081_RS07335	COG1610	YqeY-like protein
G7081_RS07345	COG0735	belongs to the Fur family
G7081_RS07350	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G7081_RS07355	COG0640	Transcriptional regulator
G7081_RS07365	COG0789	Transcriptional regulator
G7081_RS07370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G7081_RS07375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G7081_RS07380	COG0584	glycerophosphoryl diester phosphodiesterase
G7081_RS07390	COG2003	Belongs to the UPF0758 family
G7081_RS07395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G7081_RS07400	COG0285	dihydrofolate synthase activity
G7081_RS07405	COG0525	valine-tRNA ligase activity
G7081_RS07410	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G7081_RS07415	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G7081_RS07420	COG0301	tRNA thio-modification
G7081_RS07425	COG1104	cysteine desulfurase activity
G7081_RS07430	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
G7081_RS07440	COG3091	SprT-like family
G7081_RS07445	COG2183	response to ionizing radiation
G7081_RS07455	COG1705	Flagellar rod assembly protein muramidase FlgJ
G7081_RS07455	COG3942	CHAP domain
G7081_RS07485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G7081_RS07490	COG0351	phosphomethylpyrimidine kinase
G7081_RS07500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G7081_RS07505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G7081_RS07510	COG1705	Flagellar rod assembly protein muramidase FlgJ
G7081_RS07515	COG1876	peptidase activity
G7081_RS07565	COG1321	iron dependent repressor
G7081_RS07570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G7081_RS07575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G7081_RS07580	COG3599	regulation of cell shape
G7081_RS07585	COG2302	S4 RNA-binding domain
G7081_RS07590	COG0762	integral membrane protein
G7081_RS07595	COG1799	cell septum assembly
G7081_RS07600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G7081_RS07605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G7081_RS07610	COG0849	cell division
G7081_RS07615	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G7081_RS07620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G7081_RS07625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)