locus-tag	class	description
BHY08_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BHY08_RS00010	COG0592	DNA-directed DNA polymerase activity
BHY08_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BHY08_RS00030	COG0187	DNA topoisomerase II activity
BHY08_RS00045	COG0360	Binds together with S18 to 16S ribosomal RNA
BHY08_RS00050	COG0629	single-stranded DNA binding
BHY08_RS00060	COG0359	binds to the 23S rRNA
BHY08_RS00065	COG0305	Participates in initiation and elongation during chromosome replication
BHY08_RS00070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BHY08_RS00075	COG1307	EDD domain protein, DegV family
BHY08_RS00090	COG0488	(ABC) transporter
BHY08_RS00095	COG0142	geranyltranstransferase activity
BHY08_RS00130	COG1609	Transcriptional regulator
BHY08_RS00135	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BHY08_RS00145	COG1744	ABC transporter substrate-binding protein PnrA-like
BHY08_RS00150	COG3845	ABC transporter
BHY08_RS00155	COG4603	Belongs to the binding-protein-dependent transport system permease family
BHY08_RS00160	COG1079	Belongs to the binding-protein-dependent transport system permease family
BHY08_RS00165	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BHY08_RS00170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BHY08_RS00175	COG0813	purine-nucleoside phosphorylase activity
BHY08_RS00185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BHY08_RS00190	COG0477	Major facilitator Superfamily
BHY08_RS00205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BHY08_RS00210	COG4565	transcriptional regulatory protein
BHY08_RS00215	COG3290	protein histidine kinase activity
BHY08_RS00220	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BHY08_RS00225	COG1242	4 iron, 4 sulfur cluster binding
BHY08_RS00230	COG0671	phosphoesterase, PA-phosphatase related
BHY08_RS00250	COG1388	LysM domain
BHY08_RS00250	COG1705	Flagellar rod assembly protein muramidase FlgJ
BHY08_RS00255	COG0495	leucyl-tRNA aminoacylation
BHY08_RS00260	COG2244	polysaccharide biosynthetic process
BHY08_RS00265	COG1187	pseudouridine synthase activity
BHY08_RS00270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHY08_RS00275	COG0584	glycerophosphoryl diester phosphodiesterase
BHY08_RS00280	COG1136	(ABC) transporter
BHY08_RS00280	COG0577	efflux transmembrane transporter activity
BHY08_RS00280	COG1136	(ABC) transporter
BHY08_RS00280	COG0577	efflux transmembrane transporter activity
BHY08_RS00310	COG2816	NAD+ diphosphatase activity
BHY08_RS00325	COG1126	abc transporter atp-binding protein
BHY08_RS00330	COG0765	amino acid transport
BHY08_RS00340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BHY08_RS00360	COG3620	sequence-specific DNA binding
BHY08_RS00385	COG0039	L-malate dehydrogenase activity
BHY08_RS00390	COG0193	aminoacyl-tRNA hydrolase activity
BHY08_RS00395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BHY08_RS00400	COG2244	polysaccharide biosynthetic process
BHY08_RS00405	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BHY08_RS00415	COG1098	S1 RNA binding domain
BHY08_RS00420	COG0037	tRNA processing
BHY08_RS00425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BHY08_RS00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BHY08_RS00440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BHY08_RS00445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BHY08_RS00575	COG4463	regulation of RNA biosynthetic process
BHY08_RS00580	COG0542	response to heat
BHY08_RS00590	COG0826	peptidase U32
BHY08_RS00595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHY08_RS00600	COG1271	oxidase subunit
BHY08_RS00605	COG1294	oxidase, subunit
BHY08_RS00610	COG4988	ABC transporter
BHY08_RS00615	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BHY08_RS00630	COG0475	glutathione-regulated potassium exporter activity
BHY08_RS00640	COG3942	CHAP domain
BHY08_RS00655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BHY08_RS00660	COG3679	Belongs to the UPF0342 family
BHY08_RS00675	COG3481	metal-dependent phosphohydrolase, HD sub domain
BHY08_RS00680	COG3764	Sortase (surface protein transpeptidase)
BHY08_RS00690	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHY08_RS00695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BHY08_RS00705	COG0736	holo-[acyl-carrier-protein] synthase activity
BHY08_RS00725	COG1561	YicC-like family, N-terminal region
BHY08_RS00730	COG0194	GDP metabolic process
BHY08_RS00735	COG1758	RNA polymerase activity
BHY08_RS00740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BHY08_RS00750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BHY08_RS00755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BHY08_RS00755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHY08_RS00765	COG0515	serine threonine protein kinase
BHY08_RS00765	COG2815	serine threonine protein kinase
BHY08_RS00770	COG1162	GTPase activity
BHY08_RS00775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BHY08_RS00795	COG1461	Dihydroxyacetone kinase
BHY08_RS00800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BHY08_RS00805	COG0416	fatty acid biosynthetic process
BHY08_RS00810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BHY08_RS00850	COG1136	(ABC) transporter
BHY08_RS00905	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BHY08_RS00910	COG1028	Short-chain dehydrogenase reductase Sdr
BHY08_RS00920	COG0800	Aldolase
BHY08_RS00935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BHY08_RS00935	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BHY08_RS00940	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BHY08_RS00945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_RS00950	COG3715	PTS system
BHY08_RS00980	COG2188	Transcriptional regulator
BHY08_RS00985	COG2222	sugar isomerase
BHY08_RS00990	COG3684	Belongs to the aldolase LacD family
BHY08_RS01005	COG1438	arginine binding
BHY08_RS01015	COG0018	arginyl-trna synthetase
BHY08_RS01020	COG1349	DNA-binding transcription factor activity
BHY08_RS01025	COG1105	Belongs to the carbohydrate kinase PfkB family
BHY08_RS01030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BHY08_RS01030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHY08_RS01030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BHY08_RS01035	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHY08_RS01035	COG2918	glutathione biosynthetic process
BHY08_RS01040	COG3711	transcriptional antiterminator
BHY08_RS01045	COG2190	(PTS) system
BHY08_RS01045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_RS01045	COG1263	PTS System
BHY08_RS01050	COG2723	6-phospho-beta-galactosidase activity
BHY08_RS01060	COG1012	belongs to the aldehyde dehydrogenase family
BHY08_RS01065	COG5506	Protein of unknown function (DUF1694)
BHY08_RS01070	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BHY08_RS01075	COG4605	iron ion homeostasis
BHY08_RS01080	COG4604	ABC transporter, ATP-binding protein
BHY08_RS01085	COG4607	ABC-type enterochelin transport system periplasmic component
BHY08_RS01095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BHY08_RS01115	COG1447	Phosphotransferase system cellobiose-specific component IIA
BHY08_RS01130	COG1737	Transcriptional regulator
BHY08_RS01135	COG2246	polysaccharide biosynthetic process
BHY08_RS01145	COG0463	Glycosyl transferase, family 2
BHY08_RS01170	COG4493	Belongs to the UPF0637 family
BHY08_RS01180	COG0084	hydrolase, TatD family'
BHY08_RS01185	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BHY08_RS01190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BHY08_RS01200	COG3842	ATPase activity
BHY08_RS01205	COG1803	Methylglyoxal synthase
BHY08_RS01210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BHY08_RS01215	COG1011	Hydrolase
BHY08_RS01225	COG1132	(ABC) transporter
BHY08_RS01240	COG3584	3D domain protein
BHY08_RS01240	COG1388	LysM domain
BHY08_RS01245	COG0860	N-Acetylmuramoyl-L-alanine amidase
BHY08_RS01250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BHY08_RS01255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BHY08_RS01265	COG4608	Belongs to the ABC transporter superfamily
BHY08_RS01270	COG0601	transmembrane transport
BHY08_RS01275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BHY08_RS01280	COG0747	negative chemotaxis
BHY08_RS01285	COG0571	ribonuclease III activity
BHY08_RS01290	COG1196	nuclear chromosome segregation
BHY08_RS01295	COG0561	phosphatase activity
BHY08_RS01300	COG0552	protein localization to endoplasmic reticulum
BHY08_RS01305	COG1349	DNA-binding transcription factor activity
BHY08_RS01310	COG1012	belongs to the aldehyde dehydrogenase family
BHY08_RS01320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BHY08_RS01325	COG3962	Belongs to the TPP enzyme family
BHY08_RS01330	COG1082	Xylose isomerase domain protein TIM barrel
BHY08_RS01335	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BHY08_RS01340	COG0673	inositol 2-dehydrogenase activity
BHY08_RS01365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BHY08_RS01385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BHY08_RS01390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BHY08_RS01395	COG1780	Probably involved in ribonucleotide reductase function
BHY08_RS01400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BHY08_RS01420	COG0745	RESPONSE REGULATOR receiver
BHY08_RS01425	COG5002	protein histidine kinase activity
BHY08_RS01440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BHY08_RS01445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHY08_RS01450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BHY08_RS01465	COG2003	Belongs to the UPF0758 family
BHY08_RS01530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BHY08_RS01550	COG3711	transcriptional antiterminator
BHY08_RS01575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BHY08_RS01590	COG2003	Belongs to the UPF0758 family
BHY08_RS01640	COG1136	(ABC) transporter
BHY08_RS01645	COG0577	efflux transmembrane transporter activity
BHY08_RS01650	COG0745	RESPONSE REGULATOR receiver
BHY08_RS01655	COG5002	protein histidine kinase activity
BHY08_RS01670	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BHY08_RS01690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BHY08_RS01695	COG0402	S-adenosylhomocysteine deaminase activity
BHY08_RS01700	COG2272	Belongs to the type-B carboxylesterase lipase family
BHY08_RS01725	COG2188	Transcriptional regulator
BHY08_RS01730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHY08_RS01735	COG1446	asparaginase
BHY08_RS01740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BHY08_RS01745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BHY08_RS01765	COG1175	transmembrane transport
BHY08_RS01770	COG0395	ABC-type sugar transport system, permease component
BHY08_RS01780	COG3842	ATPase activity
BHY08_RS01785	COG1349	DNA-binding transcription factor activity
BHY08_RS01795	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BHY08_RS01800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHY08_RS01815	COG0494	nUDIX hydrolase
BHY08_RS01830	COG0625	glutathione transferase activity
BHY08_RS01870	COG0783	Belongs to the Dps family
BHY08_RS01910	COG0318	PFAM AMP-dependent synthetase and ligase
BHY08_RS01915	COG1169	isochorismate synthase
BHY08_RS01920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BHY08_RS01925	COG0596	Alpha beta hydrolase
BHY08_RS01930	COG4948	Mandelate Racemase Muconate Lactonizing
BHY08_RS01935	COG2252	PERMEase
BHY08_RS01940	COG0402	S-adenosylhomocysteine deaminase activity
BHY08_RS01950	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BHY08_RS01955	COG0431	NADPH-dependent FMN reductase
BHY08_RS01960	COG1854	S-ribosylhomocysteine lyase activity
BHY08_RS01965	COG0803	Belongs to the bacterial solute-binding protein 9 family
BHY08_RS01965	COG3443	Belongs to the bacterial solute-binding protein 9 family
BHY08_RS01975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BHY08_RS01985	COG0523	cobalamin synthesis protein
BHY08_RS02000	COG0142	geranyltranstransferase activity
BHY08_RS02005	COG1346	cytolysis
BHY08_RS02015	COG3279	Response regulator of the LytR AlgR family
BHY08_RS02020	COG3275	phosphorelay sensor kinase activity
BHY08_RS02030	COG0789	Transcriptional regulator
BHY08_RS02035	COG0628	permease
BHY08_RS02045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BHY08_RS02050	COG1426	Protein conserved in bacteria
BHY08_RS02055	COG0300	oxidoreductase activity
BHY08_RS02060	COG0612	Peptidase, M16
BHY08_RS02065	COG0612	Peptidase, M16
BHY08_RS02070	COG1970	mechanosensitive ion channel activity
BHY08_RS02075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BHY08_RS02085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BHY08_RS02090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BHY08_RS02095	COG1121	(ABC) transporter
BHY08_RS02100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BHY08_RS02105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BHY08_RS02110	COG1177	transmembrane transport
BHY08_RS02115	COG1176	ABC-type spermidine putrescine transport system, permease component I
BHY08_RS02120	COG3842	ATPase activity
BHY08_RS02130	COG0604	alcohol dehydrogenase
BHY08_RS02135	COG1473	amidohydrolase
BHY08_RS02140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BHY08_RS02145	COG0038	chloride channel
BHY08_RS02150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BHY08_RS02155	COG0708	Exodeoxyribonuclease III
BHY08_RS02170	COG0802	atpase or kinase
BHY08_RS02175	COG0280	phosphate acetyltransferase
BHY08_RS02180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BHY08_RS02185	COG0561	phosphatase activity
BHY08_RS02195	COG2502	aspartate--ammonia ligase
BHY08_RS02200	COG1609	Transcriptional regulator
BHY08_RS02210	COG1175	transmembrane transport
BHY08_RS02215	COG0395	ABC-type sugar transport system, permease component
BHY08_RS02240	COG1940	carbohydrate kinase activity
BHY08_RS02260	COG2814	Major facilitator Superfamily
BHY08_RS02270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BHY08_RS02275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BHY08_RS02285	COG1464	Belongs to the NlpA lipoprotein family
BHY08_RS02290	COG1473	amidohydrolase
BHY08_RS02295	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BHY08_RS02300	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BHY08_RS02320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BHY08_RS02325	COG1959	2 iron, 2 sulfur cluster binding
BHY08_RS02345	COG1363	Peptidase, m42
BHY08_RS02350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHY08_RS02360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHY08_RS02365	COG4472	Bacterial protein of unknown function (DUF965)
BHY08_RS02370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BHY08_RS02375	COG3906	Belongs to the UPF0473 family
BHY08_RS02390	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BHY08_RS02405	COG1193	negative regulation of DNA recombination
BHY08_RS02410	COG3118	belongs to the thioredoxin family
BHY08_RS02415	COG0322	excinuclease ABC activity
BHY08_RS02425	COG1252	NADH dehydrogenase
BHY08_RS02430	COG1760	l-serine dehydratase
BHY08_RS02435	COG1760	l-serine dehydratase
BHY08_RS02440	COG1546	Belongs to the CinA family
BHY08_RS02440	COG1058	Belongs to the CinA family
BHY08_RS02445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BHY08_RS02450	COG1418	mRNA catabolic process
BHY08_RS02455	COG1328	CTP reductase activity
BHY08_RS02470	COG0745	RESPONSE REGULATOR receiver
BHY08_RS02475	COG1363	Peptidase, m42
BHY08_RS02480	COG1234	tRNA 3'-trailer cleavage
BHY08_RS02485	COG0095	Lipoate-protein ligase
BHY08_RS02490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BHY08_RS02500	COG0537	adenosine 5'-monophosphoramidase activity
BHY08_RS02505	COG1131	(ABC) transporter
BHY08_RS02510	COG4473	ABC transporter
BHY08_RS02515	COG0510	thiamine kinase activity
BHY08_RS02520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BHY08_RS02530	COG2376	Dihydroxyacetone kinase
BHY08_RS02535	COG1461	Dihydroxyacetone kinase
BHY08_RS02540	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BHY08_RS02550	COG2376	Dihydroxyacetone kinase
BHY08_RS02565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BHY08_RS02570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BHY08_RS02575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BHY08_RS02580	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BHY08_RS02585	COG4122	O-methyltransferase activity
BHY08_RS02600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BHY08_RS02610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BHY08_RS02615	COG0006	proline dipeptidase activity
BHY08_RS02620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BHY08_RS02625	COG1302	Protein conserved in bacteria
BHY08_RS02630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHY08_RS02645	COG1570	exodeoxyribonuclease VII activity
BHY08_RS02650	COG1722	exodeoxyribonuclease VII activity
BHY08_RS02655	COG0142	geranyltranstransferase activity
BHY08_RS02660	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BHY08_RS02665	COG1438	arginine binding
BHY08_RS02670	COG0497	DNA recombination
BHY08_RS02685	COG2001	Belongs to the MraZ family
BHY08_RS02690	COG0275	rRNA processing
BHY08_RS02695	COG4839	cell division protein FtsL
BHY08_RS02700	COG0768	penicillin binding
BHY08_RS02705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BHY08_RS02710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BHY08_RS02715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BHY08_RS02720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BHY08_RS02725	COG0849	cell division
BHY08_RS02730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BHY08_RS02735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BHY08_RS02740	COG1799	cell septum assembly
BHY08_RS02755	COG3599	regulation of cell shape
BHY08_RS02760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BHY08_RS02775	COG1609	Transcriptional regulator
BHY08_RS02780	COG2723	6-phospho-beta-galactosidase activity
BHY08_RS02785	COG1263	PTS System
BHY08_RS02785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_RS02785	COG2190	(PTS) system
BHY08_RS02790	COG3711	transcriptional antiterminator
BHY08_RS02795	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BHY08_RS02800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BHY08_RS02815	COG0363	glucosamine-6-phosphate deaminase activity
BHY08_RS02820	COG0765	amino acid transport
BHY08_RS02825	COG1126	abc transporter atp-binding protein
BHY08_RS02830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BHY08_RS02840	COG0531	amino acid
BHY08_RS02845	COG0673	inositol 2-dehydrogenase activity
BHY08_RS02850	COG1942	4-Oxalocrotonate Tautomerase
BHY08_RS02875	COG3976	FMN-binding domain protein
BHY08_RS02875	COG1053	succinate dehydrogenase
BHY08_RS02875	COG0431	NADPH-dependent FMN reductase
BHY08_RS02890	COG0628	permease
BHY08_RS02895	COG0583	DNA-binding transcription factor activity
BHY08_RS02905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BHY08_RS02920	COG1174	glycine betaine transport
BHY08_RS02930	COG1174	glycine betaine transport
BHY08_RS02935	COG0436	Aminotransferase
BHY08_RS02960	COG1695	Transcriptional regulator
BHY08_RS02985	COG1136	(ABC) transporter
BHY08_RS03000	COG2268	Band 7 protein
BHY08_RS03005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BHY08_RS03020	COG2076	Multidrug Resistance protein
BHY08_RS03025	COG2076	Multidrug Resistance protein
BHY08_RS03035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BHY08_RS03040	COG1595	DNA-templated transcription, initiation
BHY08_RS03055	COG0542	response to heat
BHY08_RS03065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BHY08_RS03070	COG0438	transferase activity, transferring glycosyl groups
BHY08_RS03075	COG0438	transferase activity, transferring glycosyl groups
BHY08_RS03085	COG2084	Dehydrogenase
BHY08_RS03090	COG4703	Protein of unknown function (DUF1797)
BHY08_RS03100	COG0544	peptidyl-prolyl cis-trans isomerase activity
BHY08_RS03105	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BHY08_RS03115	COG0745	RESPONSE REGULATOR receiver
BHY08_RS03120	COG5002	protein histidine kinase activity
BHY08_RS03125	COG3682	Transcriptional regulator
BHY08_RS03130	COG2217	Heavy metal translocating P-type atpase
BHY08_RS03135	COG3942	CHAP domain
BHY08_RS03135	COG1388	LysM domain
BHY08_RS03145	COG0446	pyridine nucleotide-disulphide oxidoreductase
BHY08_RS03150	COG1940	carbohydrate kinase activity
BHY08_RS03165	COG0450	alkyl hydroperoxide reductase
BHY08_RS03190	COG3448	diguanylate cyclase activity
BHY08_RS03190	COG4175	Glycine betaine
BHY08_RS03205	COG3973	AAA domain
BHY08_RS03215	COG4716	Myosin-crossreactive antigen
BHY08_RS03225	COG3425	synthase
BHY08_RS03230	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BHY08_RS03235	COG1363	Peptidase, m42
BHY08_RS03245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BHY08_RS03260	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
BHY08_RS03265	COG1518	maintenance of DNA repeat elements
BHY08_RS03270	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BHY08_RS03280	COG2814	Major facilitator Superfamily
BHY08_RS03295	COG0367	asparagine synthase
BHY08_RS03305	COG1794	racemase activity, acting on amino acids and derivatives
BHY08_RS03310	COG4946	Tricorn protease homolog
BHY08_RS03310	COG1506	peptidase
BHY08_RS03310	COG0823	Involved in the tonB-independent uptake of proteins
BHY08_RS03320	COG1268	BioY protein
BHY08_RS03325	COG0726	polysaccharide deacetylase
BHY08_RS03330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BHY08_RS03330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BHY08_RS03335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BHY08_RS03350	COG2824	Alkylphosphonate utilization operon protein PhnA
BHY08_RS03355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BHY08_RS03360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHY08_RS03375	COG2197	response regulator
BHY08_RS03380	COG0569	domain protein
BHY08_RS03385	COG4841	protein insertion into membrane
BHY08_RS03395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BHY08_RS03400	COG4838	Belongs to the UPF0358 family
BHY08_RS03405	COG0772	Belongs to the SEDS family
BHY08_RS03410	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BHY08_RS03425	COG4471	UPF0298 protein
BHY08_RS03430	COG0742	ribosomal rna small subunit methyltransferase
BHY08_RS03435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BHY08_RS03440	COG3480	Lon protease (S16) C-terminal proteolytic domain
BHY08_RS03445	COG1596	polysaccharide export
BHY08_RS03445	COG1555	photosystem II stabilization
BHY08_RS03455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BHY08_RS03460	COG2131	deaminase
BHY08_RS03465	COG2333	competence protein COMEC
BHY08_RS03465	COG0658	competence protein
BHY08_RS03470	COG1466	dna polymerase III delta subunit
BHY08_RS03480	COG1307	EDD domain protein, DegV family
BHY08_RS03490	COG2217	Heavy metal translocating P-type atpase
BHY08_RS03495	COG1968	undecaprenyl-diphosphatase activity
BHY08_RS03520	COG0052	Belongs to the universal ribosomal protein uS2 family
BHY08_RS03525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BHY08_RS03530	COG0528	UMP kinase activity
BHY08_RS03535	COG0233	cytoplasmic translational termination
BHY08_RS03540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BHY08_RS03545	COG4589	Belongs to the CDS family
BHY08_RS03550	COG0750	zinc metalloprotease
BHY08_RS03555	COG0442	prolyl-tRNA aminoacylation
BHY08_RS03565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BHY08_RS03570	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BHY08_RS03575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BHY08_RS03580	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BHY08_RS03585	COG1609	Transcriptional regulator
BHY08_RS03595	COG0779	Required for maturation of 30S ribosomal subunits
BHY08_RS03600	COG0195	Participates in both transcription termination and antitermination
BHY08_RS03605	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BHY08_RS03620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BHY08_RS03625	COG0673	inositol 2-dehydrogenase activity
BHY08_RS03635	COG0196	riboflavin kinase activity
BHY08_RS03640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BHY08_RS03645	COG1420	regulation of RNA biosynthetic process
BHY08_RS03650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BHY08_RS03655	COG0443	Heat shock 70 kDa protein
BHY08_RS03660	COG0484	heat shock protein binding
BHY08_RS03665	COG0803	Belongs to the bacterial solute-binding protein 9 family
BHY08_RS03670	COG0697	spore germination
BHY08_RS03675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BHY08_RS03680	COG0561	phosphatase activity
BHY08_RS03685	COG1078	dGTPase activity
BHY08_RS03690	COG0095	Lipoate-protein ligase
BHY08_RS03700	COG3343	RNA polymerase activity
BHY08_RS03710	COG1012	belongs to the aldehyde dehydrogenase family
BHY08_RS03715	COG0191	fructose-bisphosphate aldolase activity
BHY08_RS03720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BHY08_RS03725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BHY08_RS03730	COG0254	rRNA binding
BHY08_RS03745	COG1368	sulfuric ester hydrolase activity
BHY08_RS03760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BHY08_RS03770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BHY08_RS03775	COG0336	Belongs to the RNA methyltransferase TrmD family
BHY08_RS03780	COG0335	large ribosomal subunit rRNA binding
BHY08_RS03790	COG1098	S1 RNA binding domain
BHY08_RS03845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BHY08_RS03845	COG1199	ATP-dependent helicase activity
BHY08_RS03855	COG0436	Aminotransferase
BHY08_RS03870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BHY08_RS03885	COG1316	TRANSCRIPTIONal
BHY08_RS03890	COG3579	cysteine-type endopeptidase activity
BHY08_RS03895	COG0556	nucleotide-excision repair
BHY08_RS03900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BHY08_RS03910	COG0573	inorganic phosphate transmembrane transporter activity
BHY08_RS03915	COG0581	inorganic phosphate transmembrane transporter activity
BHY08_RS03920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BHY08_RS03925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BHY08_RS03930	COG0704	Plays a role in the regulation of phosphate uptake
BHY08_RS03935	COG0137	argininosuccinate synthase activity
BHY08_RS03945	COG0739	heme binding
BHY08_RS03945	COG0741	lytic transglycosylase activity
BHY08_RS03945	COG1196	nuclear chromosome segregation
BHY08_RS03960	COG1983	PspC domain protein
BHY08_RS03965	COG1950	PFAM Membrane protein of
BHY08_RS03980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHY08_RS03995	COG1131	(ABC) transporter
BHY08_RS04000	COG0228	four-way junction DNA binding
BHY08_RS04005	COG1837	Belongs to the UPF0109 family
BHY08_RS04010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BHY08_RS04015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BHY08_RS04015	COG0574	Belongs to the PEP-utilizing enzyme family
BHY08_RS04020	COG0517	IMP dehydrogenase activity
BHY08_RS04025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BHY08_RS04045	COG0446	pyridine nucleotide-disulphide oxidoreductase
BHY08_RS04050	COG1937	Protein conserved in bacteria
BHY08_RS04055	COG2367	Beta-lactamase
BHY08_RS04060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BHY08_RS04065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BHY08_RS04065	COG0302	gtp cyclohydrolase
BHY08_RS04070	COG0302	gtp cyclohydrolase
BHY08_RS04075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BHY08_RS04110	COG2207	Transcriptional regulator
BHY08_RS04125	COG1609	Transcriptional regulator
BHY08_RS04135	COG1869	D-ribose catabolic process
BHY08_RS04140	COG4975	Glucose uptake
BHY08_RS04165	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BHY08_RS04175	COG1979	alcohol dehydrogenase
BHY08_RS04180	COG0247	lactate metabolic process
BHY08_RS04185	COG1139	Iron-sulfur cluster binding protein
BHY08_RS04190	COG1556	Lactate utilization protein
BHY08_RS04210	COG0765	amino acid transport
BHY08_RS04215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BHY08_RS04220	COG1942	4-Oxalocrotonate Tautomerase
BHY08_RS04235	COG0557	exoribonuclease II activity
BHY08_RS04240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BHY08_RS04245	COG0356	it plays a direct role in the translocation of protons across the membrane
BHY08_RS04250	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BHY08_RS04255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BHY08_RS04260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BHY08_RS04265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BHY08_RS04270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BHY08_RS04275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BHY08_RS04280	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BHY08_RS04305	COG2508	Transcriptional regulator
BHY08_RS04310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BHY08_RS04325	COG1129	ABC transporter
BHY08_RS04340	COG0706	membrane insertase activity
BHY08_RS04345	COG1254	Belongs to the acylphosphatase family
BHY08_RS04350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BHY08_RS04360	COG1733	regulation of RNA biosynthetic process
BHY08_RS04365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BHY08_RS04370	COG0072	phenylalanine-tRNA ligase activity
BHY08_RS04370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHY08_RS04375	COG1686	Belongs to the peptidase S11 family
BHY08_RS04380	COG0656	L-ascorbic acid biosynthetic process
BHY08_RS04385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHY08_RS04390	COG1104	cysteine desulfurase activity
BHY08_RS04400	COG0482	sulfurtransferase activity
BHY08_RS04420	COG1126	abc transporter atp-binding protein
BHY08_RS04425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BHY08_RS04440	COG4807	Protein conserved in bacteria
BHY08_RS04445	COG1671	Belongs to the UPF0178 family
BHY08_RS04450	COG2188	Transcriptional regulator
BHY08_RS04460	COG2723	6-phospho-beta-galactosidase activity
BHY08_RS04470	COG2860	membrane
BHY08_RS04475	COG0488	(ABC) transporter
BHY08_RS04480	COG0280	phosphate acetyltransferase
BHY08_RS04485	COG3426	butyrate kinase activity
BHY08_RS04490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHY08_RS04495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BHY08_RS04500	COG0022	dehydrogenase e1 component
BHY08_RS04505	COG0508	dehydrogenase complex catalyzes the overall conversion of
BHY08_RS04515	COG0583	DNA-binding transcription factor activity
BHY08_RS04520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BHY08_RS04525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BHY08_RS04545	COG0772	Belongs to the SEDS family
BHY08_RS04550	COG0492	ferredoxin-NADP+ reductase activity
BHY08_RS04555	COG1609	Transcriptional regulator
BHY08_RS04560	COG1272	protein, Hemolysin III
BHY08_RS04565	COG1307	EDD domain protein, DegV family
BHY08_RS04570	COG2755	lipolytic protein G-D-S-L family
BHY08_RS04580	COG4479	Belongs to the UPF0346 family
BHY08_RS04585	COG0793	Belongs to the peptidase S41A family
BHY08_RS04585	COG3409	Peptidoglycan-binding domain 1 protein
BHY08_RS04600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BHY08_RS04605	COG0758	DNA mediated transformation
BHY08_RS04610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BHY08_RS04615	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BHY08_RS04620	COG4974	Belongs to the 'phage' integrase family
BHY08_RS04625	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BHY08_RS04630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BHY08_RS04635	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BHY08_RS04645	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BHY08_RS04660	COG1610	YqeY-like protein
BHY08_RS04670	COG1280	lysine exporter protein (LysE YggA)
BHY08_RS04670	COG1674	ftsk spoiiie
BHY08_RS04675	COG0463	Glycosyl transferase, family 2
BHY08_RS04695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BHY08_RS04700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BHY08_RS04705	COG0154	amidase activity
BHY08_RS04710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BHY08_RS04715	COG1597	lipid kinase activity
BHY08_RS04720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BHY08_RS04725	COG1131	(ABC) transporter
BHY08_RS04750	COG2514	catechol 2,3-dioxygenase activity
BHY08_RS04760	COG1687	branched-chain amino acid
BHY08_RS04765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BHY08_RS04770	COG0488	(ABC) transporter
BHY08_RS04775	COG1368	sulfuric ester hydrolase activity
BHY08_RS04780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BHY08_RS04785	COG0710	3-dehydroquinate dehydratase activity
BHY08_RS04790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BHY08_RS04800	COG2081	HI0933 family
BHY08_RS04805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BHY08_RS04830	COG0187	DNA topoisomerase II activity
BHY08_RS04835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BHY08_RS04840	COG1882	Formate acetyltransferase
BHY08_RS04845	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BHY08_RS04855	COG1227	inorganic diphosphatase activity
BHY08_RS04865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHY08_RS04895	COG0745	RESPONSE REGULATOR receiver
BHY08_RS04900	COG3850	Histidine kinase
BHY08_RS04900	COG5002	protein histidine kinase activity
BHY08_RS04905	COG4476	Belongs to the UPF0223 family
BHY08_RS04910	COG0483	inositol monophosphate 1-phosphatase activity
BHY08_RS04915	COG1217	gtp-binding protein TYPA
BHY08_RS04920	COG2384	SAM-dependent methyltransferase
BHY08_RS04925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BHY08_RS04930	COG2195	Cleaves the N-terminal amino acid of tripeptides
BHY08_RS04935	COG0542	response to heat
BHY08_RS04960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BHY08_RS04975	COG2188	Transcriptional regulator
BHY08_RS04985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BHY08_RS04985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BHY08_RS04990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BHY08_RS04995	COG0237	dephospho-CoA kinase activity
BHY08_RS05005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BHY08_RS05015	COG1484	DNA-dependent DNA replication
BHY08_RS05025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BHY08_RS05030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BHY08_RS05035	COG1832	CoA-binding protein
BHY08_RS05055	COG3639	organic phosphonate transmembrane transporter activity
BHY08_RS05060	COG0737	Belongs to the 5'-nucleotidase family
BHY08_RS05070	COG2337	Toxic component of a toxin-antitoxin (TA) module
BHY08_RS05080	COG1160	GTP binding
BHY08_RS05095	COG0481	GTPase activity
BHY08_RS05120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHY08_RS05130	COG2217	Heavy metal translocating P-type atpase
BHY08_RS05135	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BHY08_RS05145	COG0582	viral genome integration into host DNA
BHY08_RS05160	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BHY08_RS05170	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BHY08_RS05175	COG0287	Prephenate dehydrogenase
BHY08_RS05185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BHY08_RS05190	COG0077	Prephenate dehydratase
BHY08_RS05195	COG1119	ATPase activity
BHY08_RS05245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BHY08_RS05265	COG4120	Belongs to the binding-protein-dependent transport system permease family
BHY08_RS05285	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BHY08_RS05310	COG3223	Belongs to the PsiE family
BHY08_RS05320	COG0284	orotidine-5'-phosphate decarboxylase activity
BHY08_RS05325	COG0167	dihydroorotate dehydrogenase activity
BHY08_RS05330	COG0543	2 iron, 2 sulfur cluster binding
BHY08_RS05345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BHY08_RS05350	COG0540	Belongs to the ATCase OTCase family
BHY08_RS05355	COG2233	PERMEase
BHY08_RS05365	COG0564	pseudouridine synthase activity
BHY08_RS05370	COG1823	symporter activity
BHY08_RS05375	COG0251	oxidation-reduction process
BHY08_RS05380	COG0626	cystathionine gamma-synthase activity
BHY08_RS05385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BHY08_RS05400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BHY08_RS05405	COG0577	efflux transmembrane transporter activity
BHY08_RS05410	COG1136	(ABC) transporter
BHY08_RS05425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHY08_RS05435	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BHY08_RS05440	COG2252	PERMEase
BHY08_RS05445	COG0577	efflux transmembrane transporter activity
BHY08_RS05445	COG1136	(ABC) transporter
BHY08_RS05450	COG1136	(ABC) transporter
BHY08_RS05465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BHY08_RS05470	COG0358	DNA primase activity
BHY08_RS05475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BHY08_RS05490	COG1136	(ABC) transporter
BHY08_RS05500	COG1132	(ABC) transporter
BHY08_RS05505	COG1132	(ABC) transporter
BHY08_RS05510	COG3763	UPF0154 protein
BHY08_RS05515	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BHY08_RS05520	COG0765	amino acid transport
BHY08_RS05525	COG0765	amino acid transport
BHY08_RS05530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BHY08_RS05540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BHY08_RS05550	COG0751	glycine-tRNA ligase activity
BHY08_RS05555	COG0752	glycyl-tRNA synthetase alpha subunit
BHY08_RS05560	COG1381	Involved in DNA repair and RecF pathway recombination
BHY08_RS05565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BHY08_RS05575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BHY08_RS05585	COG1702	phosphate starvation-inducible protein PhoH
BHY08_RS05610	COG0719	Fe-S assembly protein
BHY08_RS05620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BHY08_RS05625	COG0719	Fe-S assembly protein
BHY08_RS05640	COG1464	Belongs to the NlpA lipoprotein family
BHY08_RS05645	COG2011	ABC-type metal ion transport system permease component
BHY08_RS05650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BHY08_RS05655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BHY08_RS05665	COG3716	PTS system mannose fructose sorbose family IID component
BHY08_RS05670	COG3715	PTS system
BHY08_RS05690	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BHY08_RS05690	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BHY08_RS05695	COG0513	Belongs to the DEAD box helicase family
BHY08_RS05705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BHY08_RS05710	COG1307	EDD domain protein, DegV family
BHY08_RS05725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BHY08_RS05735	COG0393	Putative heavy-metal-binding
BHY08_RS05745	COG0789	Transcriptional regulator
BHY08_RS05750	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BHY08_RS05755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BHY08_RS05760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BHY08_RS05765	COG0584	glycerophosphoryl diester phosphodiesterase
BHY08_RS05775	COG1573	uracil-dna glycosylase
BHY08_RS05780	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BHY08_RS05785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BHY08_RS05790	COG1940	carbohydrate kinase activity
BHY08_RS05800	COG0457	Tetratricopeptide repeat
BHY08_RS05800	COG0705	Rhomboid family
BHY08_RS05805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BHY08_RS05820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BHY08_RS05835	COG0726	polysaccharide deacetylase
BHY08_RS05840	COG0076	glutamate decarboxylase activity
BHY08_RS05865	COG0460	homoserine dehydrogenase
BHY08_RS05870	COG0527	aspartate kinase activity
BHY08_RS05875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BHY08_RS05885	COG3759	membrane
BHY08_RS05895	COG0778	Nitroreductase
BHY08_RS05900	COG0604	alcohol dehydrogenase
BHY08_RS05905	COG1846	Transcriptional regulator
BHY08_RS05920	COG2151	metal-sulfur cluster biosynthetic enzyme
BHY08_RS05925	COG0825	malonyl-CoA metabolic process
BHY08_RS05930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BHY08_RS05935	COG0439	Biotin carboxylase
BHY08_RS05940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHY08_RS05950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BHY08_RS05960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BHY08_RS05975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHY08_RS05985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BHY08_RS05990	COG0778	Nitroreductase
BHY08_RS05995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BHY08_RS06000	COG0798	PFAM Bile acid sodium symporter
BHY08_RS06030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BHY08_RS06035	COG1073	alpha beta
BHY08_RS06040	COG2153	protein acetylation
BHY08_RS06055	COG0668	transmembrane transport
BHY08_RS06065	COG0517	IMP dehydrogenase activity
BHY08_RS06075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BHY08_RS06085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BHY08_RS06090	COG0456	acetyltransferase
BHY08_RS06095	COG1214	PFAM Peptidase M22, glycoprotease
BHY08_RS06095	COG0456	acetyltransferase
BHY08_RS06100	COG1214	PFAM Peptidase M22, glycoprotease
BHY08_RS06110	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BHY08_RS06115	COG0363	glucosamine-6-phosphate deaminase activity
BHY08_RS06120	COG0710	3-dehydroquinate dehydratase activity
BHY08_RS06125	COG0640	Transcriptional regulator
BHY08_RS06130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHY08_RS06145	COG0617	tRNA 3'-terminal CCA addition
BHY08_RS06150	COG1694	Mazg nucleotide pyrophosphohydrolase
BHY08_RS06155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BHY08_RS06165	COG0457	Tetratricopeptide repeat
BHY08_RS06170	COG2261	transglycosylase associated protein
BHY08_RS06180	COG1160	GTP binding
BHY08_RS06185	COG0539	negative regulation of cytoplasmic translation
BHY08_RS06200	COG0514	ATP-dependent DNA helicase (RecQ)
BHY08_RS06215	COG2755	lipolytic protein G-D-S-L family
BHY08_RS06215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BHY08_RS06220	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BHY08_RS06225	COG1187	pseudouridine synthase activity
BHY08_RS06230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BHY08_RS06235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BHY08_RS06250	COG0735	belongs to the Fur family
BHY08_RS06255	COG2996	Protein conserved in bacteria
BHY08_RS06260	COG2814	Major facilitator Superfamily
BHY08_RS06270	COG0205	6-phosphofructokinase activity
BHY08_RS06275	COG0587	DNA-directed DNA polymerase activity
BHY08_RS06285	COG2814	Major facilitator Superfamily
BHY08_RS06290	COG0477	Major facilitator Superfamily
BHY08_RS06295	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BHY08_RS06305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BHY08_RS06310	COG0768	penicillin binding
BHY08_RS06320	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BHY08_RS06335	COG1040	competence protein
BHY08_RS06340	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BHY08_RS06360	COG1739	Uncharacterized protein family UPF0029
BHY08_RS06365	COG2188	Transcriptional regulator
BHY08_RS06390	COG0516	GMP reductase activity
BHY08_RS06390	COG0517	IMP dehydrogenase activity
BHY08_RS06400	COG0411	ABC transporter
BHY08_RS06410	COG0559	Belongs to the binding-protein-dependent transport system permease family
BHY08_RS06420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BHY08_RS06430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BHY08_RS06450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BHY08_RS06455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BHY08_RS06460	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BHY08_RS06465	COG3257	ureidoglycine aminohydrolase activity
BHY08_RS06470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHY08_RS06480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BHY08_RS06485	COG1953	Uracil, thiamine, allantoin
BHY08_RS06500	COG0772	Belongs to the SEDS family
BHY08_RS06510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BHY08_RS06515	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BHY08_RS06520	COG1481	regulation of sporulation
BHY08_RS06525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BHY08_RS06530	COG1660	Displays ATPase and GTPase activities
BHY08_RS06535	COG2177	Part of the ABC transporter FtsEX involved in
BHY08_RS06540	COG2884	Cell division ATP-binding protein ftsE
BHY08_RS06545	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BHY08_RS06550	COG0653	protein targeting
BHY08_RS06555	COG0561	phosphatase activity
BHY08_RS06575	COG0148	phosphopyruvate hydratase activity
BHY08_RS06580	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BHY08_RS06585	COG0149	triose-phosphate isomerase activity
BHY08_RS06600	COG2390	Transcriptional regulator
BHY08_RS06605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BHY08_RS06615	COG0740	serine-type endopeptidase activity
BHY08_RS06625	COG5002	protein histidine kinase activity
BHY08_RS06630	COG0745	RESPONSE REGULATOR receiver
BHY08_RS06635	COG1132	(ABC) transporter
BHY08_RS06640	COG1132	(ABC) transporter
BHY08_RS06645	COG0516	GMP reductase activity
BHY08_RS06655	COG1131	(ABC) transporter
BHY08_RS06660	COG4989	oxidoreductase activity
BHY08_RS06675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BHY08_RS06695	COG4467	Involved in initiation control of chromosome replication
BHY08_RS06700	COG1774	PSP1 C-terminal conserved region
BHY08_RS06705	COG0470	DNA polymerase III
BHY08_RS06710	COG3870	Protein conserved in bacteria
BHY08_RS06715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BHY08_RS06720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BHY08_RS06725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BHY08_RS06730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BHY08_RS06740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BHY08_RS06765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BHY08_RS06770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BHY08_RS06775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BHY08_RS06795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BHY08_RS06800	COG0572	uridine kinase
BHY08_RS06805	COG4619	ABC transporter
BHY08_RS06810	COG0390	transport system, permease component
BHY08_RS06820	COG4608	Belongs to the ABC transporter superfamily
BHY08_RS06825	COG0444	Belongs to the ABC transporter superfamily
BHY08_RS06830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BHY08_RS06835	COG0601	transmembrane transport
BHY08_RS06845	COG4166	transmembrane transport
BHY08_RS06855	COG3716	PTS system mannose fructose sorbose family IID component
BHY08_RS06860	COG3715	PTS system
BHY08_RS06870	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHY08_RS06870	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_RS06875	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BHY08_RS06875	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BHY08_RS06900	COG0076	glutamate decarboxylase activity
BHY08_RS06905	COG0076	glutamate decarboxylase activity
BHY08_RS06910	COG1511	domain protein
BHY08_RS06915	COG0531	amino acid
BHY08_RS06925	COG0583	DNA-binding transcription factor activity
BHY08_RS06930	COG2855	membrane
BHY08_RS06935	COG1335	isochorismatase
BHY08_RS06950	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BHY08_RS06955	COG3853	Toxic anion resistance protein (TelA)
BHY08_RS06960	COG0735	belongs to the Fur family
BHY08_RS06965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BHY08_RS06970	COG1278	Cold shock
BHY08_RS06990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BHY08_RS06995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BHY08_RS07000	COG3442	glutamine amidotransferase
BHY08_RS07015	COG1482	cell wall glycoprotein biosynthetic process
BHY08_RS07030	COG1132	(ABC) transporter
BHY08_RS07045	COG0492	ferredoxin-NADP+ reductase activity
BHY08_RS07050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BHY08_RS07060	COG0647	UMP catabolic process
BHY08_RS07065	COG4470	Protein conserved in bacteria
BHY08_RS07070	COG0737	Belongs to the 5'-nucleotidase family
BHY08_RS07075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BHY08_RS07080	COG2365	Tyrosine phosphatase family
BHY08_RS07090	COG2249	NAD(P)H dehydrogenase (quinone) activity
BHY08_RS07100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BHY08_RS07105	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BHY08_RS07110	COG0116	Belongs to the methyltransferase superfamily
BHY08_RS07125	COG3331	DNA recombination
BHY08_RS07130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BHY08_RS07135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BHY08_RS07145	COG2070	2-Nitropropane dioxygenase
BHY08_RS07150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BHY08_RS07160	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BHY08_RS07165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BHY08_RS07170	COG0009	L-threonylcarbamoyladenylate synthase
BHY08_RS07175	COG2890	protein-(glutamine-N5) methyltransferase activity
BHY08_RS07180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BHY08_RS07185	COG1435	thymidine kinase activity
BHY08_RS07190	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BHY08_RS07215	COG1378	Sugar-specific transcriptional regulator TrmB
BHY08_RS07220	COG1122	ATPase activity
BHY08_RS07225	COG4120	Belongs to the binding-protein-dependent transport system permease family
BHY08_RS07260	COG2706	6-phosphogluconolactonase activity
BHY08_RS07280	COG2195	Cleaves the N-terminal amino acid of tripeptides
BHY08_RS07285	COG4166	transmembrane transport
BHY08_RS07290	COG0765	amino acid transport
BHY08_RS07295	COG1126	abc transporter atp-binding protein
BHY08_RS07300	COG0436	Aminotransferase
BHY08_RS07310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BHY08_RS07315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHY08_RS07320	COG0509	glycine decarboxylation via glycine cleavage system
BHY08_RS07325	COG1393	Belongs to the ArsC family
BHY08_RS07335	COG0772	Belongs to the SEDS family
BHY08_RS07340	COG5416	Lipopolysaccharide assembly protein A domain
BHY08_RS07345	COG0300	oxidoreductase activity
BHY08_RS07355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BHY08_RS07360	COG2226	methyltransferase
BHY08_RS07385	COG1304	FMN binding
BHY08_RS07395	COG1323	Belongs to the UPF0348 family
BHY08_RS07400	COG2226	methyltransferase
BHY08_RS07405	COG0799	negative regulation of ribosome biogenesis
BHY08_RS07410	COG1713	HD superfamily hydrolase involved in NAD metabolism
BHY08_RS07415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BHY08_RS07420	COG1534	Rna-binding protein
BHY08_RS07425	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BHY08_RS07435	COG1263	PTS System
BHY08_RS07435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_RS07435	COG2190	(PTS) system
BHY08_RS07440	COG2190	(PTS) system
BHY08_RS07440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_RS07440	COG1263	PTS System
BHY08_RS07445	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BHY08_RS07450	COG1737	Transcriptional regulator
BHY08_RS07465	COG0138	bifunctional purine biosynthesis protein purh
BHY08_RS07470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BHY08_RS07475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BHY08_RS07485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BHY08_RS07495	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BHY08_RS07500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BHY08_RS07505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BHY08_RS07510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BHY08_RS07515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BHY08_RS07520	COG1070	Carbohydrate kinase
BHY08_RS07530	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BHY08_RS07535	COG1228	amidohydrolase
BHY08_RS07540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BHY08_RS07545	COG0124	histidyl-tRNA synthetase
BHY08_RS07550	COG2986	histidine ammonia-lyase
BHY08_RS07555	COG0531	amino acid
BHY08_RS07570	COG3404	Formiminotransferase-cyclodeaminase
BHY08_RS07585	COG1705	Flagellar rod assembly protein muramidase FlgJ
BHY08_RS07585	COG3942	CHAP domain
BHY08_RS07595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BHY08_RS07615	COG0446	pyridine nucleotide-disulphide oxidoreductase
BHY08_RS07650	COG1216	Glycosyl transferase, family 2
BHY08_RS07655	COG1091	dTDP-4-dehydrorhamnose reductase activity
BHY08_RS07660	COG1088	dTDP-glucose 4,6-dehydratase activity
BHY08_RS07670	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BHY08_RS07705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BHY08_RS07710	COG1253	flavin adenine dinucleotide binding
BHY08_RS07715	COG0628	permease
BHY08_RS07730	COG3557	Belongs to the UPF0374 family
BHY08_RS07735	COG1194	a g-specific adenine glycosylase
BHY08_RS07740	COG2137	regulation of response to DNA damage stimulus
BHY08_RS07775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BHY08_RS07785	COG1091	dTDP-4-dehydrorhamnose reductase activity
BHY08_RS07800	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BHY08_RS07810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BHY08_RS07830	COG1215	transferase activity, transferring glycosyl groups
BHY08_RS07840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BHY08_RS07850	COG4464	protein tyrosine phosphatase activity
BHY08_RS07865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BHY08_RS07865	COG0463	Glycosyl transferase, family 2
BHY08_RS07870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BHY08_RS07875	COG1682	transport, permease protein
BHY08_RS07880	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BHY08_RS07885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BHY08_RS07890	COG1134	teichoic acid transport
BHY08_RS07895	COG1316	TRANSCRIPTIONal
BHY08_RS07900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BHY08_RS07905	COG1295	ribonuclease BN
BHY08_RS07910	COG0024	Methionine aminopeptidase
BHY08_RS07915	COG0716	FMN binding
BHY08_RS07925	COG2309	aminopeptidase activity
BHY08_RS07930	COG0301	tRNA thio-modification
BHY08_RS07935	COG1104	cysteine desulfurase activity
BHY08_RS07940	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BHY08_RS07950	COG4608	Belongs to the ABC transporter superfamily
BHY08_RS07955	COG0444	Belongs to the ABC transporter superfamily
BHY08_RS07960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BHY08_RS07975	COG1464	Belongs to the NlpA lipoprotein family
BHY08_RS07980	COG2011	ABC-type metal ion transport system permease component
BHY08_RS07985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BHY08_RS08000	COG3091	SprT-like family
BHY08_RS08005	COG2183	response to ionizing radiation
BHY08_RS08025	COG1705	Flagellar rod assembly protein muramidase FlgJ
BHY08_RS08030	COG1876	peptidase activity
BHY08_RS08040	COG4129	membrane
BHY08_RS08055	COG0577	efflux transmembrane transporter activity
BHY08_RS08060	COG1136	(ABC) transporter
BHY08_RS08065	COG0642	Histidine kinase
BHY08_RS08070	COG0745	RESPONSE REGULATOR receiver
BHY08_RS08080	COG0716	FMN binding
BHY08_RS08085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BHY08_RS08095	COG0584	glycerophosphoryl diester phosphodiesterase
BHY08_RS08100	COG3338	carbonate dehydratase activity
BHY08_RS08120	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BHY08_RS08125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BHY08_RS08130	COG1696	Membrane protein involved in D-alanine export
BHY08_RS08165	COG1074	ATP-dependent DNA helicase activity
BHY08_RS08170	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BHY08_RS08185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BHY08_RS08190	COG1121	(ABC) transporter
BHY08_RS08205	COG0504	CTP synthase activity
BHY08_RS08210	COG0659	secondary active sulfate transmembrane transporter activity
BHY08_RS08235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BHY08_RS08240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BHY08_RS08245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHY08_RS08250	COG0427	acetyl-CoA hydrolase
BHY08_RS08255	COG1024	Enoyl-CoA hydratase
BHY08_RS08260	COG1250	3-hydroxyacyl-CoA dehydrogenase
BHY08_RS08265	COG1960	acyl-CoA dehydrogenase activity
BHY08_RS08270	COG0183	Belongs to the thiolase family
BHY08_RS08280	COG1960	acyl-CoA dehydrogenase activity
BHY08_RS08285	COG0662	Cupin 2, conserved barrel domain protein
BHY08_RS08295	COG0590	tRNA wobble adenosine to inosine editing
BHY08_RS08305	COG2738	Putative neutral zinc metallopeptidase
BHY08_RS08315	COG2199	diguanylate cyclase activity
BHY08_RS08315	COG2203	Gaf domain
BHY08_RS08320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BHY08_RS08330	COG0366	Alpha amylase catalytic
BHY08_RS08335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_RS08335	COG1263	PTS System
BHY08_RS08340	COG2188	Transcriptional regulator
BHY08_RS08345	COG1185	polyribonucleotide nucleotidyltransferase activity
BHY08_RS08350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BHY08_RS08355	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BHY08_RS08360	COG0242	peptide deformylase activity
BHY08_RS08370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BHY08_RS08380	COG2239	Acts as a magnesium transporter
BHY08_RS08385	COG0564	pseudouridine synthase activity
BHY08_RS08390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BHY08_RS08395	COG2357	RelA SpoT domain protein
BHY08_RS08410	COG1164	Oligoendopeptidase f
BHY08_RS08420	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BHY08_RS08425	COG0531	amino acid
BHY08_RS08435	COG0488	(ABC) transporter
BHY08_RS08440	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BHY08_RS08450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BHY08_RS08455	COG0459	protein refolding
BHY08_RS08480	COG0596	Alpha beta hydrolase
BHY08_RS08530	COG0217	transcriptional regulatory protein
BHY08_RS08540	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BHY08_RS08545	COG4109	DRTGG domain
BHY08_RS08575	COG0747	negative chemotaxis
BHY08_RS08580	COG2226	methyltransferase
BHY08_RS08585	COG0829	nickel cation binding
BHY08_RS08605	COG0804	urea catabolic process
BHY08_RS08630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BHY08_RS08635	COG0351	phosphomethylpyrimidine kinase
BHY08_RS08645	COG1757	Na H antiporter
BHY08_RS08655	COG0250	Participates in transcription elongation, termination and antitermination
BHY08_RS08665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BHY08_RS08690	COG1597	lipid kinase activity
BHY08_RS08695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BHY08_RS08700	COG0406	alpha-ribazole phosphatase activity
BHY08_RS08705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BHY08_RS08710	COG0500	methyltransferase
BHY08_RS08715	COG3142	Participates in the control of copper homeostasis
BHY08_RS08720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BHY08_RS08725	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BHY08_RS08730	COG1668	transmembrane transport
BHY08_RS08735	COG4152	abc transporter atp-binding protein
BHY08_RS08770	COG1454	alcohol dehydrogenase
BHY08_RS08770	COG1012	belongs to the aldehyde dehydrogenase family
BHY08_RS08785	COG0366	Alpha amylase catalytic
BHY08_RS08795	COG0673	inositol 2-dehydrogenase activity
BHY08_RS08800	COG1082	Xylose isomerase domain protein TIM barrel
BHY08_RS08815	COG1917	Cupin 2, conserved barrel domain protein
BHY08_RS08815	COG2207	Transcriptional regulator
BHY08_RS08830	COG2190	(PTS) system
BHY08_RS08830	COG1263	PTS System
BHY08_RS08830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_RS08840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BHY08_RS08855	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BHY08_RS08860	COG0222	ribosome binding
BHY08_RS08865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BHY08_RS08870	COG0081	regulation of translation
BHY08_RS08885	COG2217	Heavy metal translocating P-type atpase
BHY08_RS08890	COG0765	amino acid transport
BHY08_RS08895	COG1126	abc transporter atp-binding protein
BHY08_RS08900	COG0371	Dehydrogenase
BHY08_RS08915	COG0343	queuine tRNA-ribosyltransferase activity
BHY08_RS08920	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BHY08_RS08925	COG2255	four-way junction helicase activity
BHY08_RS08930	COG0632	four-way junction helicase activity
BHY08_RS08940	COG0424	maF-like protein
BHY08_RS08945	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BHY08_RS08950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BHY08_RS08960	COG1692	metallophosphoesterase
BHY08_RS08975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BHY08_RS08980	COG4684	Psort location CytoplasmicMembrane, score
BHY08_RS08995	COG1054	Belongs to the UPF0176 family
BHY08_RS09000	COG2814	Major facilitator Superfamily
BHY08_RS09005	COG1490	D-aminoacyl-tRNA deacylase activity
BHY08_RS09010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BHY08_RS09015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BHY08_RS09020	COG2264	protein methyltransferase activity
BHY08_RS09030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BHY08_RS09045	COG0589	response to stress
BHY08_RS09050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BHY08_RS09055	COG0827	DNA restriction-modification system
BHY08_RS09080	COG4537	Required for transformation and DNA binding
BHY08_RS09090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHY08_RS09095	COG0217	transcriptional regulatory protein
BHY08_RS09110	COG4708	membrane
BHY08_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
BHY08_RS09130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BHY08_RS09145	COG2813	Specifically methylates the guanine in position
BHY08_RS09155	COG1607	acyl-coa hydrolase
BHY08_RS09160	COG1072	(Pantothenic acid kinase))
BHY08_RS09165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BHY08_RS09165	COG0519	Catalyzes the synthesis of GMP from XMP
BHY08_RS09205	COG2723	6-phospho-beta-galactosidase activity
BHY08_RS09210	COG1263	PTS System
BHY08_RS09210	COG2190	(PTS) system
BHY08_RS09210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHY08_RS09215	COG3711	transcriptional antiterminator
BHY08_RS09225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BHY08_RS09230	COG0513	Belongs to the DEAD box helicase family
BHY08_RS09235	COG0673	inositol 2-dehydrogenase activity
BHY08_RS09240	COG1132	(ABC) transporter
BHY08_RS09250	COG5503	Protein of unknown function (DUF1447)
BHY08_RS09260	COG2153	protein acetylation
BHY08_RS09265	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BHY08_RS09270	COG1278	Cold shock
BHY08_RS09275	COG2003	Belongs to the UPF0758 family
BHY08_RS09280	COG0546	phosphoglycolate phosphatase activity
BHY08_RS09285	COG0285	dihydrofolate synthase activity
BHY08_RS09290	COG0525	valine-tRNA ligase activity
BHY08_RS09295	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BHY08_RS09300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BHY08_RS09330	COG1045	serine acetyltransferase
BHY08_RS09340	COG4862	establishment of competence for transformation
BHY08_RS09345	COG1393	Belongs to the ArsC family
BHY08_RS09350	COG0180	Tryptophanyl-tRNA synthetase
BHY08_RS09355	COG0740	serine-type endopeptidase activity
BHY08_RS09360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BHY08_RS09365	COG4466	Protein conserved in bacteria
BHY08_RS09375	COG0789	Transcriptional regulator
BHY08_RS09380	COG2814	Major facilitator Superfamily
BHY08_RS09395	COG3688	RNA-binding protein containing a PIN domain
BHY08_RS09400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BHY08_RS09405	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BHY08_RS09410	COG0215	cysteine-tRNA ligase activity
BHY08_RS09415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHY08_RS09420	COG4956	integral membrane protein (PIN domain superfamily)
BHY08_RS09430	COG0756	dUTP diphosphatase activity
BHY08_RS09435	COG3158	transport of potassium into the cell
BHY08_RS09440	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BHY08_RS09445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BHY08_RS09465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BHY08_RS09475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BHY08_RS09480	COG0110	maltose O-acetyltransferase activity
BHY08_RS09485	COG0436	Aminotransferase
BHY08_RS09510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BHY08_RS09515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BHY08_RS09520	COG0527	aspartate kinase activity
BHY08_RS09535	COG0351	phosphomethylpyrimidine kinase
BHY08_RS09540	COG0352	thiamine-phosphate diphosphorylase activity
BHY08_RS09545	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BHY08_RS09555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BHY08_RS09565	COG1129	ABC transporter
BHY08_RS09585	COG1285	pathogenesis
BHY08_RS09670	COG1660	Displays ATPase and GTPase activities
BHY08_RS09675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BHY08_RS09710	COG0066	3-isopropylmalate dehydratase activity
BHY08_RS09720	COG0473	3-isopropylmalate dehydrogenase activity
BHY08_RS09725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BHY08_RS09730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BHY08_RS09740	COG0440	acetolactate synthase activity
BHY08_RS09745	COG0028	Belongs to the TPP enzyme family
BHY08_RS09750	COG0129	dihydroxy-acid dehydratase activity
BHY08_RS09770	COG1902	pentaerythritol trinitrate reductase activity
BHY08_RS09785	COG0519	Catalyzes the synthesis of GMP from XMP
BHY08_RS09800	COG1132	(ABC) transporter
BHY08_RS09815	COG0420	3'-5' exonuclease activity
BHY08_RS09820	COG0204	Acyl-transferase
BHY08_RS09825	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BHY08_RS09830	COG2827	Endonuclease containing a URI domain
BHY08_RS09860	COG1447	Phosphotransferase system cellobiose-specific component IIA
BHY08_RS09865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BHY08_RS09880	COG3579	cysteine-type endopeptidase activity
BHY08_RS09890	COG1914	H( )-stimulated, divalent metal cation uptake system
BHY08_RS09895	COG2271	Major facilitator Superfamily
BHY08_RS09900	COG1473	amidohydrolase
BHY08_RS09905	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BHY08_RS09905	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BHY08_RS09910	COG3716	PTS system mannose fructose sorbose family IID component
BHY08_RS09915	COG3715	PTS system
BHY08_RS09930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BHY08_RS09940	COG1304	FMN binding
BHY08_RS09945	COG1346	cytolysis
BHY08_RS10010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BHY08_RS10015	COG0583	DNA-binding transcription factor activity
BHY08_RS10020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BHY08_RS10025	COG0400	carboxylic ester hydrolase activity
BHY08_RS10030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BHY08_RS10035	COG0346	lactoylglutathione lyase activity
BHY08_RS10040	COG0346	lactoylglutathione lyase activity
BHY08_RS10045	COG1846	Transcriptional regulator
BHY08_RS10070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BHY08_RS10075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BHY08_RS10080	COG0101	tRNA pseudouridine synthase activity
BHY08_RS10090	COG1122	ATPase activity
BHY08_RS10095	COG1122	ATPase activity
BHY08_RS10100	COG0203	ribosomal protein L17
BHY08_RS10105	COG0202	RNA polymerase activity
BHY08_RS10110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BHY08_RS10115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BHY08_RS10120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BHY08_RS10125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BHY08_RS10130	COG0563	adenylate kinase activity
BHY08_RS10145	COG1841	ribosomal large subunit assembly
BHY08_RS10150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BHY08_RS10155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BHY08_RS10160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BHY08_RS10165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BHY08_RS10170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BHY08_RS10175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BHY08_RS10180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BHY08_RS10185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BHY08_RS10190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BHY08_RS10195	COG0255	Belongs to the universal ribosomal protein uL29 family
BHY08_RS10200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BHY08_RS10205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BHY08_RS10210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BHY08_RS10220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BHY08_RS10225	COG0089	rRNA binding
BHY08_RS10230	COG0088	Forms part of the polypeptide exit tunnel
BHY08_RS10235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BHY08_RS10240	COG0051	transcription antitermination factor activity, RNA binding
BHY08_RS10245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BHY08_RS10250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BHY08_RS10255	COG0049	tRNA binding
BHY08_RS10260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BHY08_RS10265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BHY08_RS10270	COG0588	phosphoglycerate mutase activity
BHY08_RS10275	COG1114	Component of the transport system for branched-chain amino acids
BHY08_RS10465	COG1686	Belongs to the peptidase S11 family
BHY08_RS10470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BHY08_RS10480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BHY08_RS10495	COG0012	GTP binding
BHY08_RS10500	COG4481	Protein conserved in bacteria
BHY08_RS10505	COG1475	DNA binding
BHY08_RS10510	COG1192	Involved in chromosome partitioning
BHY08_RS10515	COG0357	Ribosomal RNA small subunit methyltransferase G
BHY08_RS10525	COG0445	tRNA wobble uridine modification
BHY08_RS10530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BHY08_RS10535	COG4166	transmembrane transport
BHY08_RS10540	COG1847	R3H domain protein
BHY08_RS10545	COG0706	membrane insertase activity
BHY08_RS10550	COG0594	ribonuclease P activity
BHY08_RS10555	COG0230	Belongs to the bacterial ribosomal protein bL34 family