locus-tag	class	description
VAPA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VAPA_RS00010	COG0592	DNA-directed DNA polymerase activity
VAPA_RS00040	COG1408	metallophosphoesterase
VAPA_RS00050	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VAPA_RS00055	COG0392	lysyltransferase activity
VAPA_RS00060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_RS00065	COG3568	Endonuclease Exonuclease Phosphatase
VAPA_RS00095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAPA_RS00115	COG4452	Inner membrane protein CreD
VAPA_RS00130	COG2205	protein histidine kinase activity
VAPA_RS00135	COG0745	RESPONSE REGULATOR receiver
VAPA_RS00150	COG2608	mercury ion transmembrane transporter activity
VAPA_RS00155	COG2217	Heavy metal translocating P-type atpase
VAPA_RS00160	COG0456	acetyltransferase
VAPA_RS00165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAPA_RS00170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAPA_RS00180	COG0745	RESPONSE REGULATOR receiver
VAPA_RS00185	COG0642	Histidine kinase
VAPA_RS00190	COG1902	pentaerythritol trinitrate reductase activity
VAPA_RS00200	COG1024	Enoyl-CoA hydratase
VAPA_RS00215	COG0445	tRNA wobble uridine modification
VAPA_RS00220	COG0357	Ribosomal RNA small subunit methyltransferase G
VAPA_RS00230	COG1192	Involved in chromosome partitioning
VAPA_RS00250	COG0277	FAD linked oxidase domain protein
VAPA_RS00260	COG2096	Adenosyltransferase
VAPA_RS00295	COG0583	DNA-binding transcription factor activity
VAPA_RS00310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VAPA_RS00315	COG2894	cell division
VAPA_RS00320	COG0850	regulation of cytokinetic process
VAPA_RS00325	COG2233	PERMEase
VAPA_RS00330	COG2050	protein possibly involved in aromatic compounds catabolism
VAPA_RS00355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_RS00370	COG0477	Major facilitator Superfamily
VAPA_RS00385	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_RS00395	COG3246	L-lysine catabolic process to acetate
VAPA_RS00410	COG3284	Transcriptional regulator
VAPA_RS00460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAPA_RS00505	COG0492	ferredoxin-NADP+ reductase activity
VAPA_RS00520	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VAPA_RS00525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS00530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS00535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS00535	COG1116	anion transmembrane transporter activity
VAPA_RS00550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAPA_RS00565	COG3971	2-oxopent-4-enoate hydratase activity
VAPA_RS00570	COG0154	amidase activity
VAPA_RS00590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS00610	COG1950	PFAM Membrane protein of
VAPA_RS00615	COG0583	DNA-binding transcription factor activity
VAPA_RS00620	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS00625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS00645	COG1573	uracil-dna glycosylase
VAPA_RS00655	COG0804	urea catabolic process
VAPA_RS00675	COG3246	L-lysine catabolic process to acetate
VAPA_RS00680	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS00685	COG3485	protocatechuate 3,4-dioxygenase
VAPA_RS00705	COG0583	DNA-binding transcription factor activity
VAPA_RS00720	COG4548	von Willebrand factor, type A
VAPA_RS00730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VAPA_RS00740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_RS00750	COG3842	ATPase activity
VAPA_RS00755	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS00780	COG0702	epimerase
VAPA_RS00785	COG2066	Belongs to the glutaminase family
VAPA_RS00800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPA_RS00805	COG0700	Nucleoside recognition
VAPA_RS00810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_RS00840	COG0683	leucine binding
VAPA_RS00845	COG0633	Ferredoxin
VAPA_RS00880	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
VAPA_RS00885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAPA_RS00890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPA_RS00905	COG0514	ATP-dependent DNA helicase (RecQ)
VAPA_RS00915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS00930	COG2986	histidine ammonia-lyase
VAPA_RS00935	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VAPA_RS00960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_RS00965	COG0765	amino acid transport
VAPA_RS00975	COG1228	amidohydrolase
VAPA_RS00980	COG0402	S-adenosylhomocysteine deaminase activity
VAPA_RS01000	COG0583	DNA-binding transcription factor activity
VAPA_RS01010	COG1410	methionine synthase
VAPA_RS01010	COG0646	methionine synthase
VAPA_RS01035	COG1309	transcriptional regulator
VAPA_RS01085	COG1335	isochorismatase
VAPA_RS01095	COG2080	2 iron, 2 sulfur cluster binding
VAPA_RS01100	COG2010	Cytochrome c
VAPA_RS01100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_RS01230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPA_RS01230	COG0515	serine threonine protein kinase
VAPA_RS01245	COG4372	Transposase
VAPA_RS01250	COG3436	PFAM IS66 Orf2 family protein
VAPA_RS01360	COG0347	Belongs to the P(II) protein family
VAPA_RS01365	COG0004	ammonium transporteR
VAPA_RS01375	COG0583	DNA-binding transcription factor activity
VAPA_RS01380	COG0277	FAD linked oxidase domain protein
VAPA_RS01385	COG0277	FAD linked oxidase domain protein
VAPA_RS01390	COG0247	lactate metabolic process
VAPA_RS01400	COG0386	Belongs to the glutathione peroxidase family
VAPA_RS01410	COG0477	Major facilitator Superfamily
VAPA_RS01415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAPA_RS01425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPA_RS01440	COG0129	dihydroxy-acid dehydratase activity
VAPA_RS01450	COG3971	2-oxopent-4-enoate hydratase activity
VAPA_RS01460	COG3384	dioxygenase
VAPA_RS01465	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_RS01470	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPA_RS01480	COG1846	Transcriptional regulator
VAPA_RS01515	COG0583	DNA-binding transcription factor activity
VAPA_RS01525	COG1473	amidohydrolase
VAPA_RS01530	COG2974	May be involved in recombination
VAPA_RS01560	COG0745	RESPONSE REGULATOR receiver
VAPA_RS01565	COG0579	oxidoreductase
VAPA_RS01580	COG2211	Major facilitator Superfamily
VAPA_RS01595	COG4974	Belongs to the 'phage' integrase family
VAPA_RS01615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS01620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS01645	COG1079	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS01650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_RS01655	COG1335	isochorismatase
VAPA_RS01660	COG3845	ABC transporter
VAPA_RS01685	COG0583	DNA-binding transcription factor activity
VAPA_RS01690	COG0708	Exodeoxyribonuclease III
VAPA_RS01695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VAPA_RS01705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VAPA_RS01710	COG0154	amidase activity
VAPA_RS01715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VAPA_RS01720	COG1077	Cell shape determining protein MreB Mrl
VAPA_RS01735	COG0768	penicillin binding
VAPA_RS01745	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VAPA_RS01755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_RS01770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAPA_RS01805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VAPA_RS01810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAPA_RS01815	COG0583	DNA-binding transcription factor activity
VAPA_RS01830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_RS01845	COG1177	transmembrane transport
VAPA_RS01850	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPA_RS01855	COG3842	ATPase activity
VAPA_RS01875	COG0436	Aminotransferase
VAPA_RS01880	COG0028	Belongs to the TPP enzyme family
VAPA_RS01890	COG0730	response to heat
VAPA_RS01910	COG0724	RNA recognition motif
VAPA_RS01920	COG0023	Translation Initiation Factor
VAPA_RS01925	COG0513	Belongs to the DEAD box helicase family
VAPA_RS01930	COG0330	HflC and HflK could
VAPA_RS01935	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS01940	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS01955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAPA_RS01970	COG2733	membrane
VAPA_RS01980	COG0584	glycerophosphoryl diester phosphodiesterase
VAPA_RS01985	COG1473	amidohydrolase
VAPA_RS02000	COG0243	molybdopterin cofactor binding
VAPA_RS02015	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS02020	COG1070	Carbohydrate kinase
VAPA_RS02025	COG1063	alcohol dehydrogenase
VAPA_RS02030	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS02040	COG1879	ABC-type sugar transport system periplasmic component
VAPA_RS02045	COG2207	Transcriptional regulator
VAPA_RS02050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_RS02105	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS02110	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAPA_RS02115	COG1946	Acyl-CoA thioesterase
VAPA_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS02135	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS02140	COG4177	L-phenylalanine transmembrane transporter activity
VAPA_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS02165	COG1053	succinate dehydrogenase
VAPA_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS02180	COG0659	secondary active sulfate transmembrane transporter activity
VAPA_RS02230	COG0667	Aldo Keto reductase
VAPA_RS02235	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS02240	COG1129	ABC transporter
VAPA_RS02250	COG1070	Carbohydrate kinase
VAPA_RS02255	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAPA_RS02260	COG2188	Transcriptional regulator
VAPA_RS02275	COG0629	single-stranded DNA binding
VAPA_RS02290	COG0217	transcriptional regulatory protein
VAPA_RS02305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPA_RS02310	COG0482	sulfurtransferase activity
VAPA_RS02345	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS02350	COG0601	transmembrane transport
VAPA_RS02355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_RS02360	COG0444	Belongs to the ABC transporter superfamily
VAPA_RS02365	COG4608	Belongs to the ABC transporter superfamily
VAPA_RS02375	COG0747	negative chemotaxis
VAPA_RS02380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAPA_RS02395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAPA_RS02405	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
VAPA_RS02410	COG0735	belongs to the Fur family
VAPA_RS02415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPA_RS02420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VAPA_RS02440	COG1522	sequence-specific DNA binding
VAPA_RS02445	COG0058	SHG alpha-glucan phosphorylase activity
VAPA_RS02450	COG0297	glycogen (starch) synthase activity
VAPA_RS02455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAPA_RS02460	COG1523	belongs to the glycosyl hydrolase 13 family
VAPA_RS02465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAPA_RS02470	COG0366	Alpha amylase catalytic
VAPA_RS02475	COG2072	flavoprotein involved in K transport
VAPA_RS02500	COG0495	leucyl-tRNA aminoacylation
VAPA_RS02515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VAPA_RS02525	COG3158	transport of potassium into the cell
VAPA_RS02545	COG3135	benzoate transporter
VAPA_RS02550	COG0189	ligase activity
VAPA_RS02565	COG0121	glutamine amidotransferase
VAPA_RS02575	COG2814	Major facilitator Superfamily
VAPA_RS02590	COG0205	6-phosphofructokinase activity
VAPA_RS02600	COG1024	Enoyl-CoA hydratase
VAPA_RS02605	COG0183	Belongs to the thiolase family
VAPA_RS02615	COG0583	DNA-binding transcription factor activity
VAPA_RS02620	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VAPA_RS02640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VAPA_RS02650	COG1414	Transcriptional regulator
VAPA_RS02655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPA_RS02660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS02665	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS02695	COG0018	arginyl-trna synthetase
VAPA_RS02710	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VAPA_RS02715	COG1137	ATPase activity
VAPA_RS02720	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VAPA_RS02725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_RS02785	COG0069	glutamate synthase activity
VAPA_RS02790	COG0653	protein targeting
VAPA_RS02815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VAPA_RS02835	COG1335	isochorismatase
VAPA_RS02845	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
VAPA_RS02860	COG2967	ApaG domain
VAPA_RS02865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VAPA_RS02920	COG5002	protein histidine kinase activity
VAPA_RS02930	COG0784	Response regulator, receiver
VAPA_RS02930	COG2205	protein histidine kinase activity
VAPA_RS02930	COG2198	Histidine kinase
VAPA_RS02935	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VAPA_RS02940	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VAPA_RS02965	COG0515	serine threonine protein kinase
VAPA_RS03145	COG2072	flavoprotein involved in K transport
VAPA_RS03155	COG2144	transferase activity, transferring acyl groups
VAPA_RS03180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_RS03250	COG2129	metallophosphoesterase
VAPA_RS03265	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS03270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS03275	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
VAPA_RS03285	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS03290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS03300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPA_RS03305	COG2329	Antibiotic biosynthesis monooxygenase
VAPA_RS03310	COG0400	carboxylic ester hydrolase activity
VAPA_RS03330	COG0583	DNA-binding transcription factor activity
VAPA_RS03335	COG2853	Lipoprotein
VAPA_RS03385	COG0583	DNA-binding transcription factor activity
VAPA_RS03390	COG1942	4-Oxalocrotonate Tautomerase
VAPA_RS03395	COG2267	carboxylic ester hydrolase activity
VAPA_RS03415	COG4214	carbohydrate transport
VAPA_RS03430	COG0583	DNA-binding transcription factor activity
VAPA_RS03460	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
VAPA_RS03505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPA_RS03515	COG3284	Transcriptional regulator
VAPA_RS03525	COG0165	Argininosuccinate lyase
VAPA_RS03535	COG3344	reverse transcriptase
VAPA_RS03540	COG3473	Maleate cis-trans isomerase
VAPA_RS03545	COG0583	DNA-binding transcription factor activity
VAPA_RS03575	COG0546	phosphoglycolate phosphatase activity
VAPA_RS03595	COG0512	Glutamine amidotransferase of anthranilate synthase
VAPA_RS03610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAPA_RS03615	COG0134	indole-3-glycerol-phosphate synthase activity
VAPA_RS03620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VAPA_RS03640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAPA_RS03660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VAPA_RS03665	COG0081	regulation of translation
VAPA_RS03670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VAPA_RS03675	COG0222	ribosome binding
VAPA_RS03680	COG0085	RNA polymerase activity
VAPA_RS03685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VAPA_RS03705	COG5000	phosphorelay sensor kinase activity
VAPA_RS03710	COG2204	response regulator
VAPA_RS03730	COG0840	transmembrane signaling receptor activity
VAPA_RS03775	COG0154	amidase activity
VAPA_RS03790	COG0776	regulation of translation
VAPA_RS03795	COG0583	DNA-binding transcription factor activity
VAPA_RS03815	COG2205	protein histidine kinase activity
VAPA_RS03820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VAPA_RS03835	COG0210	DNA helicase
VAPA_RS03840	COG0679	Auxin Efflux Carrier
VAPA_RS03855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VAPA_RS03860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VAPA_RS03870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAPA_RS03900	COG0583	DNA-binding transcription factor activity
VAPA_RS03905	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS03915	COG1215	transferase activity, transferring glycosyl groups
VAPA_RS03920	COG1649	PFAM Uncharacterised BCR, COG1649
VAPA_RS03920	COG0726	polysaccharide deacetylase
VAPA_RS03950	COG0038	chloride channel
VAPA_RS03965	COG0384	phenazine biosynthesis protein PhzF
VAPA_RS03970	COG0625	glutathione transferase activity
VAPA_RS03975	COG1280	lysine exporter protein (LysE YggA)
VAPA_RS03985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_RS03990	COG0697	spore germination
VAPA_RS04015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_RS04040	COG0463	Glycosyl transferase, family 2
VAPA_RS04040	COG0457	Tetratricopeptide repeat
VAPA_RS04070	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VAPA_RS04090	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VAPA_RS04090	COG0662	Cupin 2, conserved barrel domain protein
VAPA_RS04095	COG1216	Glycosyl transferase, family 2
VAPA_RS04095	COG0438	transferase activity, transferring glycosyl groups
VAPA_RS04100	COG1215	transferase activity, transferring glycosyl groups
VAPA_RS04110	COG2755	lipolytic protein G-D-S-L family
VAPA_RS04110	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAPA_RS04125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAPA_RS04130	COG0438	transferase activity, transferring glycosyl groups
VAPA_RS04130	COG1216	Glycosyl transferase, family 2
VAPA_RS04135	COG0438	transferase activity, transferring glycosyl groups
VAPA_RS04135	COG1216	Glycosyl transferase, family 2
VAPA_RS04140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAPA_RS04145	COG1309	transcriptional regulator
VAPA_RS04165	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VAPA_RS04170	COG2721	sulfolactate sulfo-lyase activity
VAPA_RS04175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_RS04185	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS04190	COG2186	Transcriptional regulator
VAPA_RS04195	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS04205	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPA_RS04215	COG0683	leucine binding
VAPA_RS04245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAPA_RS04250	COG0066	3-isopropylmalate dehydratase activity
VAPA_RS04290	COG0583	DNA-binding transcription factor activity
VAPA_RS04295	COG4221	oxidoreductase activity
VAPA_RS04305	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS04315	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_RS04315	COG1024	Enoyl-CoA hydratase
VAPA_RS04320	COG2852	Protein conserved in bacteria
VAPA_RS04325	COG0183	Belongs to the thiolase family
VAPA_RS04350	COG1024	Enoyl-CoA hydratase
VAPA_RS04355	COG0683	leucine binding
VAPA_RS04365	COG5265	(ABC) transporter
VAPA_RS04370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPA_RS04375	COG0154	amidase activity
VAPA_RS04380	COG0583	DNA-binding transcription factor activity
VAPA_RS04385	COG1027	Aspartate ammonia-lyase
VAPA_RS04390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_RS04395	COG0765	amino acid transport
VAPA_RS04400	COG0765	amino acid transport
VAPA_RS04405	COG1126	abc transporter atp-binding protein
VAPA_RS04415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS04420	COG3344	reverse transcriptase
VAPA_RS04425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPA_RS04425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_RS04430	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPA_RS04440	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS04445	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS04450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS04455	COG1024	Enoyl-CoA hydratase
VAPA_RS04460	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS04465	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS04470	COG0183	Belongs to the thiolase family
VAPA_RS04475	COG1024	Enoyl-CoA hydratase
VAPA_RS04475	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_RS04480	COG0583	DNA-binding transcription factor activity
VAPA_RS04490	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
VAPA_RS04505	COG0154	amidase activity
VAPA_RS04510	COG0444	Belongs to the ABC transporter superfamily
VAPA_RS04515	COG4608	Belongs to the ABC transporter superfamily
VAPA_RS04520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_RS04525	COG0601	transmembrane transport
VAPA_RS04530	COG0747	negative chemotaxis
VAPA_RS04545	COG0418	dihydroorotase activity
VAPA_RS04560	COG0501	Belongs to the peptidase M48B family
VAPA_RS04570	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VAPA_RS04575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPA_RS04580	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VAPA_RS04590	COG1846	Transcriptional regulator
VAPA_RS04605	COG1566	PFAM secretion protein HlyD family protein
VAPA_RS04615	COG2814	Major facilitator Superfamily
VAPA_RS04625	COG1187	pseudouridine synthase activity
VAPA_RS04630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAPA_RS04635	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS04680	COG0656	L-ascorbic acid biosynthetic process
VAPA_RS04685	COG2814	Major facilitator Superfamily
VAPA_RS04710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VAPA_RS04725	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAPA_RS04730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAPA_RS04735	COG0523	cobalamin synthesis protein
VAPA_RS04755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VAPA_RS04760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VAPA_RS04765	COG2001	Belongs to the MraZ family
VAPA_RS04770	COG0275	rRNA processing
VAPA_RS04775	COG3116	cell division
VAPA_RS04785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAPA_RS04790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAPA_RS04795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VAPA_RS04800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VAPA_RS04805	COG0772	Belongs to the SEDS family
VAPA_RS04810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAPA_RS04815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAPA_RS04820	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAPA_RS04825	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VAPA_RS04840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VAPA_RS04845	COG0583	DNA-binding transcription factor activity
VAPA_RS04855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VAPA_RS04860	COG0575	Belongs to the CDS family
VAPA_RS04880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAPA_RS04895	COG3150	esterase
VAPA_RS04900	COG2197	response regulator
VAPA_RS04910	COG0772	Belongs to the SEDS family
VAPA_RS04915	COG0312	modulator of DNA gyrase
VAPA_RS04925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAPA_RS04935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAPA_RS04945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAPA_RS04950	COG0511	ligase activity, forming carbon-carbon bonds
VAPA_RS04955	COG0439	Biotin carboxylase
VAPA_RS04960	COG2264	protein methyltransferase activity
VAPA_RS04970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAPA_RS04980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAPA_RS04985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAPA_RS04985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAPA_RS05015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VAPA_RS05030	COG2943	transferase activity, transferring hexosyl groups
VAPA_RS05035	COG2204	response regulator
VAPA_RS05045	COG2205	protein histidine kinase activity
VAPA_RS05050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAPA_RS05065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_RS05080	COG0037	tRNA processing
VAPA_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS05100	COG2175	clavaminate synthase activity
VAPA_RS05125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_RS05135	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
VAPA_RS05140	COG3387	PFAM Glycoside hydrolase 15-related
VAPA_RS05150	COG0617	tRNA 3'-terminal CCA addition
VAPA_RS05160	COG0625	glutathione transferase activity
VAPA_RS05165	COG1285	pathogenesis
VAPA_RS05170	COG0741	lytic transglycosylase activity
VAPA_RS05175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VAPA_RS05180	COG0583	DNA-binding transcription factor activity
VAPA_RS05205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_RS05225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAPA_RS05230	COG1522	sequence-specific DNA binding
VAPA_RS05265	COG0583	DNA-binding transcription factor activity
VAPA_RS05270	COG0477	Major facilitator Superfamily
VAPA_RS05330	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS05340	COG0583	DNA-binding transcription factor activity
VAPA_RS05350	COG2951	lytic endotransglycosylase activity
VAPA_RS05375	COG0697	spore germination
VAPA_RS05380	COG0583	DNA-binding transcription factor activity
VAPA_RS05395	COG3386	PFAM SMP-30 Gluconolaconase
VAPA_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS05410	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_RS05415	COG1879	ABC-type sugar transport system periplasmic component
VAPA_RS05420	COG4213	ABC transporter substrate-binding protein
VAPA_RS05430	COG4214	carbohydrate transport
VAPA_RS05435	COG1129	ABC transporter
VAPA_RS05440	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS05445	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS05460	COG0583	DNA-binding transcription factor activity
VAPA_RS05465	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS05485	COG0189	ligase activity
VAPA_RS05485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAPA_RS05490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAPA_RS05490	COG0189	ligase activity
VAPA_RS05495	COG1132	(ABC) transporter
VAPA_RS05510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VAPA_RS05515	COG4178	(ABC) transporter
VAPA_RS05525	COG2271	Major facilitator Superfamily
VAPA_RS05610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAPA_RS05625	COG1765	OsmC-like protein
VAPA_RS05630	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
VAPA_RS05645	COG1473	amidohydrolase
VAPA_RS05650	COG0747	negative chemotaxis
VAPA_RS05655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_RS05660	COG0444	Belongs to the ABC transporter superfamily
VAPA_RS05665	COG4608	Belongs to the ABC transporter superfamily
VAPA_RS05670	COG3385	transposase activity
VAPA_RS05675	COG3384	dioxygenase
VAPA_RS05680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VAPA_RS05685	COG1840	ABC-type Fe3 transport system, periplasmic component
VAPA_RS05695	COG3842	ATPase activity
VAPA_RS05710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VAPA_RS05715	COG0166	Belongs to the GPI family
VAPA_RS05745	COG1175	transmembrane transport
VAPA_RS05750	COG0395	ABC-type sugar transport system, permease component
VAPA_RS05755	COG3842	ATPase activity
VAPA_RS05760	COG0246	Mannitol dehydrogenase
VAPA_RS05770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VAPA_RS05780	COG4753	response regulator
VAPA_RS05780	COG2207	Transcriptional regulator
VAPA_RS05785	COG1070	Carbohydrate kinase
VAPA_RS05790	COG0459	protein refolding
VAPA_RS05795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VAPA_RS05800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_RS05805	COG4774	siderophore transport
VAPA_RS05820	COG4772	TonB-dependent receptor
VAPA_RS05825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_RS05830	COG1126	abc transporter atp-binding protein
VAPA_RS05835	COG0765	amino acid transport
VAPA_RS05840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_RS05850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAPA_RS05860	COG1560	Kdo2-lipid A biosynthetic process
VAPA_RS05870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VAPA_RS05880	COG1333	cytochrome c biogenesis protein
VAPA_RS05885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAPA_RS05890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VAPA_RS05895	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
VAPA_RS05900	COG0019	diaminopimelate decarboxylase activity
VAPA_RS05905	COG1965	Belongs to the frataxin family
VAPA_RS05940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAPA_RS05945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VAPA_RS05950	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VAPA_RS05975	COG0070	glutamate synthase
VAPA_RS05975	COG0067	glutamate synthase
VAPA_RS05975	COG0069	glutamate synthase activity
VAPA_RS05985	COG1127	ABC transporter
VAPA_RS05990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAPA_RS05995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAPA_RS06000	COG2853	Lipoprotein
VAPA_RS06015	COG1131	(ABC) transporter
VAPA_RS06020	COG0842	Transport permease protein
VAPA_RS06025	COG5007	Belongs to the BolA IbaG family
VAPA_RS06030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAPA_RS06035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VAPA_RS06050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_RS06055	COG0131	Imidazoleglycerol-phosphate dehydratase
VAPA_RS06065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VAPA_RS06070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAPA_RS06080	COG1301	dicarboxylic acid transport
VAPA_RS06090	COG0107	imidazoleglycerol-phosphate synthase activity
VAPA_RS06095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VAPA_RS06100	COG0140	phosphoribosyl-ATP diphosphatase activity
VAPA_RS06110	COG0537	adenosine 5'-monophosphoramidase activity
VAPA_RS06115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAPA_RS06120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAPA_RS06125	COG0805	protein transport
VAPA_RS06140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VAPA_RS06145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VAPA_RS06150	COG1970	mechanosensitive ion channel activity
VAPA_RS06160	COG1596	polysaccharide export
VAPA_RS06165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAPA_RS06170	COG0489	protein tyrosine kinase activity
VAPA_RS06170	COG3206	protein involved in exopolysaccharide biosynthesis
VAPA_RS06200	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPA_RS06215	COG0723	plastoquinol--plastocyanin reductase activity
VAPA_RS06220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VAPA_RS06225	COG2857	Cytochrome c1
VAPA_RS06230	COG0625	glutathione transferase activity
VAPA_RS06235	COG2969	positive regulation of protein catabolic process
VAPA_RS06255	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS06260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VAPA_RS06270	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAPA_RS06275	COG1136	(ABC) transporter
VAPA_RS06280	COG0740	serine-type endopeptidase activity
VAPA_RS06295	COG0601	transmembrane transport
VAPA_RS06325	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VAPA_RS06340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPA_RS06350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VAPA_RS06355	COG0463	Glycosyl transferase, family 2
VAPA_RS06360	COG0671	phosphoesterase, PA-phosphatase related
VAPA_RS06375	COG2030	dehydratase
VAPA_RS06375	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_RS06400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAPA_RS06405	COG2151	metal-sulfur cluster biosynthetic enzyme
VAPA_RS06410	COG3396	Phenylacetate-CoA oxygenase
VAPA_RS06415	COG3460	Phenylacetate-CoA oxygenase
VAPA_RS06420	COG3396	Phenylacetate-CoA oxygenase
VAPA_RS06430	COG2050	protein possibly involved in aromatic compounds catabolism
VAPA_RS06435	COG1024	Enoyl-CoA hydratase
VAPA_RS06445	COG1309	transcriptional regulator
VAPA_RS06450	COG2304	oxidoreductase activity
VAPA_RS06460	COG0714	Associated with various cellular activities
VAPA_RS06465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAPA_RS06470	COG0084	hydrolase, TatD family'
VAPA_RS06485	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VAPA_RS06490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAPA_RS06505	COG0583	DNA-binding transcription factor activity
VAPA_RS06545	COG1283	sodium-dependent phosphate transmembrane transporter activity
VAPA_RS06550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VAPA_RS06555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAPA_RS06580	COG1609	Transcriptional regulator
VAPA_RS06585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VAPA_RS06595	COG0196	riboflavin kinase activity
VAPA_RS06620	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS06625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VAPA_RS06645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VAPA_RS06645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAPA_RS06655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VAPA_RS06660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VAPA_RS06665	COG0492	ferredoxin-NADP+ reductase activity
VAPA_RS06675	COG1674	ftsk spoiiie
VAPA_RS06680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VAPA_RS06685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VAPA_RS06690	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS06715	COG0543	2 iron, 2 sulfur cluster binding
VAPA_RS06715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAPA_RS06765	COG2816	NAD+ diphosphatase activity
VAPA_RS06770	COG0425	Belongs to the sulfur carrier protein TusA family
VAPA_RS06780	COG0525	valine-tRNA ligase activity
VAPA_RS06785	COG3022	response to hydroperoxide
VAPA_RS06795	COG2267	carboxylic ester hydrolase activity
VAPA_RS06800	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAPA_RS06800	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAPA_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS06820	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_RS06825	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS06835	COG2079	MmgE PrpD family protein
VAPA_RS06840	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS06850	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS06860	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS06890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VAPA_RS06915	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS06920	COG0583	DNA-binding transcription factor activity
VAPA_RS06925	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VAPA_RS06940	COG0477	Major facilitator Superfamily
VAPA_RS06945	COG1304	FMN binding
VAPA_RS06950	COG0583	DNA-binding transcription factor activity
VAPA_RS06975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS06980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS06985	COG1116	anion transmembrane transporter activity
VAPA_RS06985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS06990	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
VAPA_RS06995	COG4221	oxidoreductase activity
VAPA_RS07000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_RS07005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_RS07020	COG0747	negative chemotaxis
VAPA_RS07025	COG0601	transmembrane transport
VAPA_RS07035	COG4172	Belongs to the ABC transporter superfamily
VAPA_RS07045	COG1473	amidohydrolase
VAPA_RS07050	COG2807	transmembrane transport
VAPA_RS07055	COG2186	Transcriptional regulator
VAPA_RS07070	COG1280	lysine exporter protein (LysE YggA)
VAPA_RS07090	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
VAPA_RS07110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAPA_RS07115	COG0569	domain protein
VAPA_RS07120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VAPA_RS07175	COG0165	Argininosuccinate lyase
VAPA_RS07180	COG3275	phosphorelay sensor kinase activity
VAPA_RS07215	COG0583	DNA-binding transcription factor activity
VAPA_RS07230	COG3459	Glycosyltransferase 36 associated
VAPA_RS07240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VAPA_RS07245	COG0181	hydroxymethylbilane synthase activity
VAPA_RS07265	COG1530	ribonuclease E activity
VAPA_RS07285	COG0616	signal peptide processing
VAPA_RS07285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAPA_RS07290	COG2223	nitrite transmembrane transporter activity
VAPA_RS07295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAPA_RS07300	COG0424	maF-like protein
VAPA_RS07305	COG1399	metal-binding, possibly nucleic acid-binding protein
VAPA_RS07310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VAPA_RS07315	COG0416	fatty acid biosynthetic process
VAPA_RS07320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAPA_RS07330	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS07335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAPA_RS07340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAPA_RS07365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAPA_RS07370	COG0481	GTPase activity
VAPA_RS07375	COG0681	Belongs to the peptidase S26 family
VAPA_RS07385	COG0571	ribonuclease III activity
VAPA_RS07390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VAPA_RS07395	COG1381	Involved in DNA repair and RecF pathway recombination
VAPA_RS07400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VAPA_RS07405	COG0736	holo-[acyl-carrier-protein] synthase activity
VAPA_RS07410	COG1472	Belongs to the glycosyl hydrolase 3 family
VAPA_RS07415	COG1451	nucleotide metabolic process
VAPA_RS07420	COG0443	Heat shock 70 kDa protein
VAPA_RS07425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VAPA_RS07435	COG0762	integral membrane protein
VAPA_RS07440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAPA_RS07445	COG0159	tryptophan synthase activity
VAPA_RS07450	COG0133	tryptophan synthase activity
VAPA_RS07455	COG0135	phosphoribosylanthranilate isomerase activity
VAPA_RS07460	COG0101	tRNA pseudouridine synthase activity
VAPA_RS07470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAPA_RS07475	COG0473	3-isopropylmalate dehydrogenase activity
VAPA_RS07480	COG0066	3-isopropylmalate dehydratase activity
VAPA_RS07485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAPA_RS07500	COG0372	Belongs to the citrate synthase family
VAPA_RS07505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VAPA_RS07510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VAPA_RS07515	COG1053	succinate dehydrogenase
VAPA_RS07530	COG2188	Transcriptional regulator
VAPA_RS07535	COG0039	L-malate dehydrogenase activity
VAPA_RS07540	COG4106	trans-aconitate 2-methyltransferase activity
VAPA_RS07575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VAPA_RS07600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_RS07610	COG3483	tryptophan 2,3-dioxygenase activity
VAPA_RS07620	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VAPA_RS07630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VAPA_RS07635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAPA_RS07645	COG0268	Binds directly to 16S ribosomal RNA
VAPA_RS07650	COG0728	peptidoglycan biosynthetic process
VAPA_RS07665	COG3795	YCII-related domain
VAPA_RS07670	COG3795	YCII-related domain
VAPA_RS07675	COG4941	Belongs to the sigma-70 factor family
VAPA_RS07680	COG1917	Cupin 2, conserved barrel domain protein
VAPA_RS07680	COG4977	sequence-specific DNA binding
VAPA_RS07695	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VAPA_RS07700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VAPA_RS07705	COG0617	tRNA 3'-terminal CCA addition
VAPA_RS07715	COG1392	Phosphate transport regulator
VAPA_RS07720	COG0306	phosphate transporter
VAPA_RS07735	COG0228	four-way junction DNA binding
VAPA_RS07740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VAPA_RS07745	COG0336	Belongs to the RNA methyltransferase TrmD family
VAPA_RS07750	COG0335	large ribosomal subunit rRNA binding
VAPA_RS07760	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VAPA_RS07765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_RS07770	COG1162	GTPase activity
VAPA_RS07775	COG2154	pterin-4-alpha-carbinolamine dehydratase
VAPA_RS07780	COG0501	Belongs to the peptidase M48B family
VAPA_RS07785	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VAPA_RS07790	COG0513	Belongs to the DEAD box helicase family
VAPA_RS07795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAPA_RS07800	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_RS07805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VAPA_RS07810	COG0604	alcohol dehydrogenase
VAPA_RS07835	COG4638	Rieske (2fe-2S)
VAPA_RS07860	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VAPA_RS07870	COG0683	leucine binding
VAPA_RS07910	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS07915	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS07975	COG4964	Belongs to the GSP D family
VAPA_RS08030	COG2197	response regulator
VAPA_RS08050	COG0516	GMP reductase activity
VAPA_RS08055	COG3047	cAMP biosynthetic process
VAPA_RS08060	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VAPA_RS08065	COG0210	DNA helicase
VAPA_RS08075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAPA_RS08100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_RS08105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_RS08115	COG0412	Dienelactone hydrolase
VAPA_RS08130	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VAPA_RS08135	COG4608	Belongs to the ABC transporter superfamily
VAPA_RS08140	COG0444	Belongs to the ABC transporter superfamily
VAPA_RS08145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_RS08150	COG0601	transmembrane transport
VAPA_RS08155	COG4166	transmembrane transport
VAPA_RS08180	COG3064	Membrane
VAPA_RS08220	COG1722	exodeoxyribonuclease VII activity
VAPA_RS08225	COG0142	geranyltranstransferase activity
VAPA_RS08230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VAPA_RS08235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAPA_RS08240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_RS08250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAPA_RS08255	COG0477	Major facilitator Superfamily
VAPA_RS08260	COG1910	domain protein
VAPA_RS08275	COG2188	Transcriptional regulator
VAPA_RS08285	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS08320	COG1122	ATPase activity
VAPA_RS08370	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
VAPA_RS08370	COG3608	succinylglutamate desuccinylase aspartoacylase
VAPA_RS08375	COG1320	monovalent cation:proton antiporter activity
VAPA_RS08380	COG2212	antiporter activity
VAPA_RS08390	COG0651	ATP synthesis coupled electron transport
VAPA_RS08395	COG1006	Multisubunit Na H antiporter MnhC subunit
VAPA_RS08400	COG2111	Na H antiporter
VAPA_RS08400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAPA_RS08405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VAPA_RS08430	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VAPA_RS08450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VAPA_RS08455	COG0287	Prephenate dehydrogenase
VAPA_RS08460	COG0077	Prephenate dehydratase
VAPA_RS08460	COG1605	Chorismate mutase
VAPA_RS08465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VAPA_RS08485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAPA_RS08515	COG3772	lysozyme
VAPA_RS08535	COG3668	Plasmid stabilization system
VAPA_RS08540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAPA_RS08540	COG4797	methyltransferase
VAPA_RS08550	COG1187	pseudouridine synthase activity
VAPA_RS08575	COG1546	Belongs to the CinA family
VAPA_RS08575	COG1058	Belongs to the CinA family
VAPA_RS08580	COG0174	glutamine synthetase
VAPA_RS08590	COG3852	Histidine kinase
VAPA_RS08605	COG0708	Exodeoxyribonuclease III
VAPA_RS08620	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
VAPA_RS08625	COG2205	protein histidine kinase activity
VAPA_RS08630	COG0392	lysyltransferase activity
VAPA_RS08650	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAPA_RS08670	COG0277	FAD linked oxidase domain protein
VAPA_RS08680	COG1295	ribonuclease BN
VAPA_RS08690	COG3118	belongs to the thioredoxin family
VAPA_RS08700	COG0583	DNA-binding transcription factor activity
VAPA_RS08710	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS08715	COG2267	carboxylic ester hydrolase activity
VAPA_RS08735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAPA_RS08740	COG0583	DNA-binding transcription factor activity
VAPA_RS08790	COG3265	gluconokinase activity
VAPA_RS08795	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VAPA_RS08805	COG3070	regulator of competence-specific genes
VAPA_RS08815	COG0346	lactoylglutathione lyase activity
VAPA_RS08825	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VAPA_RS08840	COG0625	glutathione transferase activity
VAPA_RS08855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VAPA_RS08860	COG2719	SpoVR family
VAPA_RS08865	COG2718	Belongs to the UPF0229 family
VAPA_RS08870	COG2766	serine protein kinase
VAPA_RS08875	COG0484	heat shock protein binding
VAPA_RS08880	COG0443	Heat shock 70 kDa protein
VAPA_RS08885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VAPA_RS08900	COG0688	phosphatidylethanolamine metabolic process
VAPA_RS08905	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS08910	COG2706	6-phosphogluconolactonase activity
VAPA_RS08920	COG2721	sulfolactate sulfo-lyase activity
VAPA_RS08925	COG2706	6-phosphogluconolactonase activity
VAPA_RS08940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS08945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPA_RS08950	COG2186	Transcriptional regulator
VAPA_RS08955	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS08960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_RS08970	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS08980	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_RS09000	COG0842	Transport permease protein
VAPA_RS09005	COG0842	Transport permease protein
VAPA_RS09010	COG1131	(ABC) transporter
VAPA_RS09015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_RS09025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_RS09035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAPA_RS09040	COG1802	Transcriptional regulator
VAPA_RS09070	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VAPA_RS09085	COG0583	DNA-binding transcription factor activity
VAPA_RS09090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPA_RS09095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS09115	COG2814	Major facilitator Superfamily
VAPA_RS09125	COG0358	DNA primase activity
VAPA_RS09130	COG1295	ribonuclease BN
VAPA_RS09130	COG1959	2 iron, 2 sulfur cluster binding
VAPA_RS09145	COG0123	including yeast histone deacetylase and acetoin utilization protein
VAPA_RS09150	COG0824	Thioesterase
VAPA_RS09160	COG3237	CsbD-like
VAPA_RS09165	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VAPA_RS09175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPA_RS09195	COG1611	Belongs to the LOG family
VAPA_RS09200	COG1024	Enoyl-CoA hydratase
VAPA_RS09205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAPA_RS09215	COG0322	excinuclease ABC activity
VAPA_RS09220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VAPA_RS09230	COG0583	DNA-binding transcription factor activity
VAPA_RS09235	COG0596	Alpha beta hydrolase
VAPA_RS09240	COG0473	3-isopropylmalate dehydrogenase activity
VAPA_RS09255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAPA_RS09275	COG1881	PFAM PEBP family protein
VAPA_RS09295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VAPA_RS09300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAPA_RS09315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAPA_RS09320	COG0670	Belongs to the BI1 family
VAPA_RS09325	COG3193	protein, possibly involved in utilization of glycolate and propanediol
VAPA_RS09375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VAPA_RS09390	COG0360	Binds together with S18 to 16S ribosomal RNA
VAPA_RS09395	COG2965	DNA replication, synthesis of RNA primer
VAPA_RS09400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VAPA_RS09405	COG0359	binds to the 23S rRNA
VAPA_RS09425	COG1673	EVE domain
VAPA_RS09435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VAPA_RS09440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VAPA_RS09450	COG0436	Aminotransferase
VAPA_RS09460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VAPA_RS09465	COG1763	Mo-molybdopterin cofactor biosynthetic process
VAPA_RS09470	COG0303	'Molybdopterin
VAPA_RS09475	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VAPA_RS09480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_RS09485	COG0314	molybdopterin synthase activity
VAPA_RS09495	COG0542	response to heat
VAPA_RS09505	COG1022	Amp-dependent synthetase and ligase
VAPA_RS09535	COG1309	transcriptional regulator
VAPA_RS09540	COG0183	Belongs to the thiolase family
VAPA_RS09560	COG0583	DNA-binding transcription factor activity
VAPA_RS09575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAPA_RS09580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAPA_RS09595	COG2814	Major facilitator Superfamily
VAPA_RS09610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VAPA_RS09615	COG3214	Protein conserved in bacteria
VAPA_RS09630	COG0673	inositol 2-dehydrogenase activity
VAPA_RS09645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS09650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS09660	COG1309	transcriptional regulator
VAPA_RS09665	COG0028	Belongs to the TPP enzyme family
VAPA_RS09700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VAPA_RS09705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VAPA_RS09710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VAPA_RS09715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VAPA_RS09720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VAPA_RS09725	COG0072	phenylalanine-tRNA ligase activity
VAPA_RS09725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAPA_RS09730	COG0776	regulation of translation
VAPA_RS09780	COG1525	nuclease
VAPA_RS09805	COG0640	Transcriptional regulator
VAPA_RS09825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAPA_RS09840	COG0431	NADPH-dependent FMN reductase
VAPA_RS09850	COG2072	flavoprotein involved in K transport
VAPA_RS09875	COG1136	(ABC) transporter
VAPA_RS09925	COG0701	Predicted permease
VAPA_RS09945	COG2186	Transcriptional regulator
VAPA_RS09950	COG1396	sequence-specific DNA binding
VAPA_RS09955	COG1396	sequence-specific DNA binding
VAPA_RS09975	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS09995	COG3246	L-lysine catabolic process to acetate
VAPA_RS10000	COG2175	clavaminate synthase activity
VAPA_RS10010	COG2207	Transcriptional regulator
VAPA_RS10030	COG2175	clavaminate synthase activity
VAPA_RS10035	COG3246	L-lysine catabolic process to acetate
VAPA_RS10045	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS10050	COG3246	L-lysine catabolic process to acetate
VAPA_RS10095	COG1024	Enoyl-CoA hydratase
VAPA_RS10105	COG2079	MmgE PrpD family protein
VAPA_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS10125	COG0596	Alpha beta hydrolase
VAPA_RS10140	COG1335	isochorismatase
VAPA_RS10170	COG1596	polysaccharide export
VAPA_RS10185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAPA_RS10190	COG0517	IMP dehydrogenase activity
VAPA_RS10190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VAPA_RS10195	COG0489	protein tyrosine kinase activity
VAPA_RS10195	COG3206	protein involved in exopolysaccharide biosynthesis
VAPA_RS10200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAPA_RS10205	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPA_RS10220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VAPA_RS10230	COG1850	ribulose-bisphosphate carboxylase activity
VAPA_RS10240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_RS10245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS10250	COG1609	Transcriptional regulator
VAPA_RS10260	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_RS10265	COG2721	sulfolactate sulfo-lyase activity
VAPA_RS10290	COG0431	NADPH-dependent FMN reductase
VAPA_RS10305	COG0346	lactoylglutathione lyase activity
VAPA_RS10310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAPA_RS10320	COG0798	PFAM Bile acid sodium symporter
VAPA_RS10335	COG2199	diguanylate cyclase activity
VAPA_RS10335	COG2200	EAL domain
VAPA_RS10335	COG3287	FIST C domain
VAPA_RS10340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAPA_RS10345	COG3300	MHYT domain
VAPA_RS10345	COG5001	Diguanylate cyclase
VAPA_RS10385	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAPA_RS10390	COG0366	Alpha amylase catalytic
VAPA_RS10395	COG0366	Alpha amylase catalytic
VAPA_RS10410	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAPA_RS10415	COG1640	4-alpha-glucanotransferase
VAPA_RS10480	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VAPA_RS10485	COG1335	isochorismatase
VAPA_RS10515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_RS10525	COG3045	CreA protein
VAPA_RS10555	COG3243	poly(R)-hydroxyalkanoic acid synthase
VAPA_RS10560	COG0183	Belongs to the thiolase family
VAPA_RS10565	COG0583	DNA-binding transcription factor activity
VAPA_RS10575	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
VAPA_RS10600	COG1058	Belongs to the CinA family
VAPA_RS10600	COG1546	Belongs to the CinA family
VAPA_RS10605	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS10610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAPA_RS10610	COG4651	solute:proton antiporter activity
VAPA_RS10660	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS10670	COG2249	NAD(P)H dehydrogenase (quinone) activity
VAPA_RS10675	COG0583	DNA-binding transcription factor activity
VAPA_RS10680	COG2197	response regulator
VAPA_RS10715	COG0028	Belongs to the TPP enzyme family
VAPA_RS10740	COG1846	Transcriptional regulator
VAPA_RS10760	COG0765	amino acid transport
VAPA_RS10775	COG4670	ketone body catabolic process
VAPA_RS10780	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS10790	COG1609	Transcriptional regulator
VAPA_RS10800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_RS10805	COG1126	abc transporter atp-binding protein
VAPA_RS10820	COG2084	Dehydrogenase
VAPA_RS10825	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS10830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPA_RS10835	COG1063	alcohol dehydrogenase
VAPA_RS10840	COG1609	Transcriptional regulator
VAPA_RS10865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAPA_RS10875	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VAPA_RS10900	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS10940	COG4221	oxidoreductase activity
VAPA_RS10945	COG0583	DNA-binding transcription factor activity
VAPA_RS10950	COG4977	sequence-specific DNA binding
VAPA_RS10950	COG1917	Cupin 2, conserved barrel domain protein
VAPA_RS10970	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
VAPA_RS10975	COG1116	anion transmembrane transporter activity
VAPA_RS10980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS10985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS10990	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAPA_RS11040	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS11045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_RS11055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_RS11060	COG0765	amino acid transport
VAPA_RS11065	COG0765	amino acid transport
VAPA_RS11070	COG1126	abc transporter atp-binding protein
VAPA_RS11105	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS11110	COG4638	Rieske (2fe-2S)
VAPA_RS11125	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS11130	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS11135	COG0028	Belongs to the TPP enzyme family
VAPA_RS11145	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPA_RS11155	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_RS11160	COG3384	dioxygenase
VAPA_RS11165	COG3971	2-oxopent-4-enoate hydratase activity
VAPA_RS11185	COG0445	tRNA wobble uridine modification
VAPA_RS11190	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS11200	COG3039	Transposase
VAPA_RS11210	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS11240	COG1942	4-Oxalocrotonate Tautomerase
VAPA_RS11245	COG4569	acetaldehyde dehydrogenase (acetylating) activity
VAPA_RS11265	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS11290	COG1802	Transcriptional regulator
VAPA_RS11295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VAPA_RS11295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VAPA_RS11305	COG1703	isobutyryl-CoA mutase activity
VAPA_RS11310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAPA_RS11315	COG4770	biotin carboxylase activity
VAPA_RS11320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAPA_RS11340	COG1522	sequence-specific DNA binding
VAPA_RS11345	COG0697	spore germination
VAPA_RS11355	COG2878	Part of a membrane complex involved in electron transport
VAPA_RS11370	COG0556	nucleotide-excision repair
VAPA_RS11375	COG1959	2 iron, 2 sulfur cluster binding
VAPA_RS11380	COG1104	cysteine desulfurase activity
VAPA_RS11385	COG0822	iron-sulfur transferase activity
VAPA_RS11400	COG0443	Heat shock 70 kDa protein
VAPA_RS11405	COG0633	Ferredoxin
VAPA_RS11470	COG0579	oxidoreductase
VAPA_RS11485	COG0167	dihydroorotate dehydrogenase activity
VAPA_RS11490	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VAPA_RS11505	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VAPA_RS11510	COG4566	intracellular signal transduction
VAPA_RS11520	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VAPA_RS11525	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAPA_RS11530	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VAPA_RS11535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAPA_RS11540	COG0791	NLP P60 protein
VAPA_RS11545	COG2133	pyrroloquinoline quinone binding
VAPA_RS11575	COG0567	Dehydrogenase, E1 component
VAPA_RS11580	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAPA_RS11585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAPA_RS11590	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VAPA_RS11610	COG1199	ATP-dependent helicase activity
VAPA_RS11620	COG0564	pseudouridine synthase activity
VAPA_RS11625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VAPA_RS11630	COG1187	pseudouridine synthase activity
VAPA_RS11635	COG0105	UTP biosynthetic process
VAPA_RS11640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VAPA_RS11655	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VAPA_RS11660	COG0124	histidyl-tRNA synthetase
VAPA_RS11675	COG1160	GTP binding
VAPA_RS11680	COG1923	regulation of RNA biosynthetic process
VAPA_RS11685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VAPA_RS11690	COG0330	HflC and HflK could
VAPA_RS11695	COG0330	HflC and HflK could
VAPA_RS11705	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
VAPA_RS11710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VAPA_RS11735	COG0626	cystathionine gamma-synthase activity
VAPA_RS11750	COG1136	(ABC) transporter
VAPA_RS11760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAPA_RS11780	COG0667	Aldo Keto reductase
VAPA_RS11785	COG2059	Chromate
VAPA_RS11795	COG1295	ribonuclease BN
VAPA_RS11815	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS11865	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS11885	COG1024	Enoyl-CoA hydratase
VAPA_RS11920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS11925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS11930	COG0235	Class ii aldolase
VAPA_RS11940	COG2186	Transcriptional regulator
VAPA_RS11945	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS11950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_RS11990	COG3385	transposase activity
VAPA_RS12020	COG0625	glutathione transferase activity
VAPA_RS12025	COG0492	ferredoxin-NADP+ reductase activity
VAPA_RS12060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAPA_RS12065	COG0573	inorganic phosphate transmembrane transporter activity
VAPA_RS12070	COG0581	inorganic phosphate transmembrane transporter activity
VAPA_RS12075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAPA_RS12090	COG5002	protein histidine kinase activity
VAPA_RS12095	COG0534	Mate efflux family protein
VAPA_RS12105	COG0254	rRNA binding
VAPA_RS12110	COG0673	inositol 2-dehydrogenase activity
VAPA_RS12115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VAPA_RS12130	COG1074	ATP-dependent DNA helicase activity
VAPA_RS12140	COG1733	regulation of RNA biosynthetic process
VAPA_RS12150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VAPA_RS12155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VAPA_RS12160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VAPA_RS12170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS12180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS12185	COG0741	lytic transglycosylase activity
VAPA_RS12185	COG1388	LysM domain
VAPA_RS12190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAPA_RS12195	COG2226	methyltransferase
VAPA_RS12200	COG0328	RNA-DNA hybrid ribonuclease activity
VAPA_RS12205	COG0303	'Molybdopterin
VAPA_RS12210	COG0746	molybdenum cofactor guanylyltransferase activity
VAPA_RS12215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VAPA_RS12220	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_RS12230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_RS12290	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VAPA_RS12300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_RS12300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VAPA_RS12315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAPA_RS12340	COG0028	Belongs to the TPP enzyme family
VAPA_RS12345	COG0440	acetolactate synthase activity
VAPA_RS12355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VAPA_RS12360	COG1183	phosphatidylcholine synthase activity
VAPA_RS12365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPA_RS12370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPA_RS12380	COG1414	Transcriptional regulator
VAPA_RS12385	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VAPA_RS12390	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VAPA_RS12420	COG1414	Transcriptional regulator
VAPA_RS12430	COG0642	Histidine kinase
VAPA_RS12435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAPA_RS12480	COG2022	thiamine diphosphate biosynthetic process
VAPA_RS12495	COG0351	phosphomethylpyrimidine kinase
VAPA_RS12510	COG2764	glyoxalase bleomycin resistance protein dioxygenase
VAPA_RS12520	COG0492	ferredoxin-NADP+ reductase activity
VAPA_RS12525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VAPA_RS12530	COG2895	sulfate adenylyltransferase (ATP) activity
VAPA_RS12565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_RS12570	COG0601	transmembrane transport
VAPA_RS12580	COG4172	Belongs to the ABC transporter superfamily
VAPA_RS12585	COG1446	asparaginase
VAPA_RS12600	COG0789	Transcriptional regulator
VAPA_RS12610	COG0667	Aldo Keto reductase
VAPA_RS12615	COG0583	DNA-binding transcription factor activity
VAPA_RS12620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_RS12625	COG3588	fructose-bisphosphate aldolase
VAPA_RS12630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAPA_RS12650	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAPA_RS12650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_RS12655	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VAPA_RS12665	COG0431	NADPH-dependent FMN reductase
VAPA_RS12670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS12675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPA_RS12680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS12685	COG1116	anion transmembrane transporter activity
VAPA_RS12700	COG1045	serine acetyltransferase
VAPA_RS12715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPA_RS12725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VAPA_RS12735	COG0450	alkyl hydroperoxide reductase
VAPA_RS12745	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VAPA_RS12755	COG4208	sulfate ABC transporter
VAPA_RS12760	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAPA_RS12765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VAPA_RS12775	COG3550	peptidyl-serine autophosphorylation
VAPA_RS12790	COG1196	nuclear chromosome segregation
VAPA_RS12800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VAPA_RS12805	COG0242	peptide deformylase activity
VAPA_RS12815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_RS12820	COG4597	amino acid ABC transporter
VAPA_RS12825	COG0765	amino acid transport
VAPA_RS12840	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VAPA_RS12845	COG0024	Methionine aminopeptidase
VAPA_RS12850	COG0047	phosphoribosylformylglycinamidine synthase activity
VAPA_RS12850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VAPA_RS12855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAPA_RS12865	COG2917	probably involved in intracellular septation
VAPA_RS12870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAPA_RS12875	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VAPA_RS12885	COG2272	Belongs to the type-B carboxylesterase lipase family
VAPA_RS12890	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS12915	COG0411	ABC transporter
VAPA_RS12925	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_RS12925	COG1024	Enoyl-CoA hydratase
VAPA_RS12930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPA_RS12935	COG0183	Belongs to the thiolase family
VAPA_RS12940	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS12965	COG2130	NADP-dependent
VAPA_RS12970	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS12990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VAPA_RS12995	COG0667	Aldo Keto reductase
VAPA_RS13000	COG2814	Major facilitator Superfamily
VAPA_RS13005	COG0583	DNA-binding transcription factor activity
VAPA_RS13030	COG0247	lactate metabolic process
VAPA_RS13030	COG0277	FAD linked oxidase domain protein
VAPA_RS13045	COG0583	DNA-binding transcription factor activity
VAPA_RS13070	COG2814	Major facilitator Superfamily
VAPA_RS13075	COG2814	Major facilitator Superfamily
VAPA_RS13080	COG2995	paraquat-inducible protein a
VAPA_RS13085	COG2995	paraquat-inducible protein a
VAPA_RS13090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAPA_RS13090	COG3008	intermembrane lipid transfer
VAPA_RS13100	COG0477	Major facilitator Superfamily
VAPA_RS13125	COG0534	Mate efflux family protein
VAPA_RS13150	COG0246	Mannitol dehydrogenase
VAPA_RS13155	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_RS13165	COG0765	amino acid transport
VAPA_RS13170	COG0765	amino acid transport
VAPA_RS13175	COG1063	alcohol dehydrogenase
VAPA_RS13190	COG2186	Transcriptional regulator
VAPA_RS13195	COG2183	response to ionizing radiation
VAPA_RS13245	COG0657	acetylesterase activity
VAPA_RS13265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VAPA_RS13270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAPA_RS13285	COG0084	hydrolase, TatD family'
VAPA_RS13290	COG0666	response to abiotic stimulus
VAPA_RS13305	COG0432	Pfam Uncharacterised protein family UPF0047
VAPA_RS13310	COG3360	Dodecin
VAPA_RS13315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAPA_RS13335	COG0515	serine threonine protein kinase
VAPA_RS13335	COG2815	serine threonine protein kinase
VAPA_RS13395	COG0589	response to stress
VAPA_RS13415	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
VAPA_RS13425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAPA_RS13460	COG3278	Belongs to the heme-copper respiratory oxidase family
VAPA_RS13470	COG2217	Heavy metal translocating P-type atpase
VAPA_RS13480	COG2207	Transcriptional regulator
VAPA_RS13485	COG0667	Aldo Keto reductase
VAPA_RS13490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VAPA_RS13495	COG0156	8-amino-7-oxononanoate synthase activity
VAPA_RS13520	COG1199	ATP-dependent helicase activity
VAPA_RS13525	COG5002	protein histidine kinase activity
VAPA_RS13525	COG2205	protein histidine kinase activity
VAPA_RS13525	COG0784	Response regulator, receiver
VAPA_RS13530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAPA_RS13565	COG1619	proteins homologs of microcin C7 resistance protein MccF
VAPA_RS13595	COG4566	intracellular signal transduction
VAPA_RS13600	COG4191	Histidine kinase
VAPA_RS13635	COG0523	cobalamin synthesis protein
VAPA_RS13680	COG0583	DNA-binding transcription factor activity
VAPA_RS13700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAPA_RS13730	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS13735	COG1733	regulation of RNA biosynthetic process
VAPA_RS13750	COG0519	Catalyzes the synthesis of GMP from XMP
VAPA_RS13750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VAPA_RS13775	COG2914	Belongs to the UPF0125 (RnfH) family
VAPA_RS13780	COG2867	negative regulation of translational initiation
VAPA_RS13785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VAPA_RS13820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VAPA_RS13825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VAPA_RS13830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VAPA_RS13835	COG0195	Participates in both transcription termination and antitermination
VAPA_RS13840	COG0779	Required for maturation of 30S ribosomal subunits
VAPA_RS13845	COG0477	Major facilitator Superfamily
VAPA_RS13850	COG4172	Belongs to the ABC transporter superfamily
VAPA_RS13855	COG4239	(ABC) transporter, permease
VAPA_RS13860	COG4174	ABC transporter (Permease)
VAPA_RS13865	COG4166	transmembrane transport
VAPA_RS13875	COG1793	dna ligase
VAPA_RS13925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAPA_RS13945	COG0583	DNA-binding transcription factor activity
VAPA_RS13950	COG0436	Aminotransferase
VAPA_RS13955	COG1643	Atp-dependent helicase
VAPA_RS13960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPA_RS13965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAPA_RS13965	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAPA_RS13985	COG2171	N-acyltransferase activity
VAPA_RS13995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPA_RS14000	COG2890	protein-(glutamine-N5) methyltransferase activity
VAPA_RS14005	COG0488	(ABC) transporter
VAPA_RS14025	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VAPA_RS14035	COG2885	chlorophyll binding
VAPA_RS14040	COG0823	Involved in the tonB-independent uptake of proteins
VAPA_RS14045	COG1132	(ABC) transporter
VAPA_RS14050	COG1530	ribonuclease E activity
VAPA_RS14055	COG0424	maF-like protein
VAPA_RS14060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VAPA_RS14065	COG0799	negative regulation of ribosome biogenesis
VAPA_RS14070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VAPA_RS14075	COG0408	coproporphyrinogen oxidase activity
VAPA_RS14080	COG0151	Belongs to the GarS family
VAPA_RS14085	COG0217	transcriptional regulatory protein
VAPA_RS14090	COG2226	methyltransferase
VAPA_RS14145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAPA_RS14160	COG0433	COG0433 Predicted ATPase
VAPA_RS14170	COG1595	DNA-templated transcription, initiation
VAPA_RS14195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VAPA_RS14200	COG1744	ABC transporter substrate-binding protein PnrA-like
VAPA_RS14210	COG3845	ABC transporter
VAPA_RS14215	COG4603	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS14220	COG1079	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS14230	COG0402	S-adenosylhomocysteine deaminase activity
VAPA_RS14265	COG2925	Exonuclease
VAPA_RS14270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_RS14275	COG0542	response to heat
VAPA_RS14280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VAPA_RS14305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VAPA_RS14310	COG1570	exodeoxyribonuclease VII activity
VAPA_RS14315	COG0811	peptide transport
VAPA_RS14320	COG0848	biopolymer transport protein
VAPA_RS14325	COG1663	tetraacyldisaccharide 4'-kinase activity
VAPA_RS14330	COG2835	tetraacyldisaccharide 4'-kinase activity
VAPA_RS14335	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VAPA_RS14340	COG0563	adenylate kinase activity
VAPA_RS14345	COG0252	asparaginase activity
VAPA_RS14350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VAPA_RS14360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_RS14365	COG2814	Major facilitator Superfamily
VAPA_RS14370	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_RS14375	COG1024	Enoyl-CoA hydratase
VAPA_RS14380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_RS14400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAPA_RS14410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPA_RS14415	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VAPA_RS14420	COG1534	Rna-binding protein
VAPA_RS14435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAPA_RS14445	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VAPA_RS14455	COG0505	Belongs to the CarA family
VAPA_RS14460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAPA_RS14465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VAPA_RS14470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPA_RS14475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPA_RS14480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAPA_RS14485	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPA_RS14500	COG0750	zinc metalloprotease
VAPA_RS14505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VAPA_RS14520	COG0233	cytoplasmic translational termination
VAPA_RS14525	COG0528	UMP kinase activity
VAPA_RS14530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VAPA_RS14535	COG0052	Belongs to the universal ribosomal protein uS2 family
VAPA_RS14545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_RS14550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VAPA_RS14550	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VAPA_RS14555	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS14560	COG0557	exoribonuclease II activity
VAPA_RS14570	COG3339	Conserved Protein
VAPA_RS14585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAPA_RS14590	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
VAPA_RS14605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAPA_RS14615	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS14640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAPA_RS14640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAPA_RS14645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAPA_RS14645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAPA_RS14650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VAPA_RS14655	COG0560	Phosphoserine phosphatase
VAPA_RS14675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_RS14680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VAPA_RS14685	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS14700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VAPA_RS14705	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VAPA_RS14710	COG1492	cobalamin metabolic process
VAPA_RS14715	COG1538	Outer membrane efflux protein
VAPA_RS14750	COG1380	Effector of murein hydrolase LrgA
VAPA_RS14755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPA_RS14760	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VAPA_RS14765	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VAPA_RS14770	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VAPA_RS14775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAPA_RS14790	COG1797	cobyrinic acid a,c-diamide synthase activity
VAPA_RS14810	COG0730	response to heat
VAPA_RS14820	COG4977	sequence-specific DNA binding
VAPA_RS14825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPA_RS14840	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS14855	COG1802	Transcriptional regulator
VAPA_RS14860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VAPA_RS14875	COG0583	DNA-binding transcription factor activity
VAPA_RS14880	COG0583	DNA-binding transcription factor activity
VAPA_RS14885	COG0129	dihydroxy-acid dehydratase activity
VAPA_RS14895	COG4654	Cytochrome c, class I
VAPA_RS14905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAPA_RS14915	COG0583	DNA-binding transcription factor activity
VAPA_RS14920	COG2910	NAD(P)H-binding
VAPA_RS14925	COG0114	fumarate hydratase activity
VAPA_RS14930	COG4175	Glycine betaine
VAPA_RS14935	COG4176	ABC-type proline glycine betaine transport system permease component
VAPA_RS14940	COG2113	Glycine betaine
VAPA_RS14985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAPA_RS14990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VAPA_RS14995	COG0740	serine-type endopeptidase activity
VAPA_RS15000	COG0544	peptidyl-prolyl cis-trans isomerase activity
VAPA_RS15015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_RS15020	COG3158	transport of potassium into the cell
VAPA_RS15030	COG1562	ergosterol biosynthetic process
VAPA_RS15035	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
VAPA_RS15050	COG1011	Hydrolase
VAPA_RS15055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VAPA_RS15085	COG0411	ABC transporter
VAPA_RS15105	COG2204	response regulator
VAPA_RS15145	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS15155	COG0642	Histidine kinase
VAPA_RS15165	COG2326	polyphosphate kinase activity
VAPA_RS15195	COG3383	formate dehydrogenase (NAD+) activity
VAPA_RS15200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAPA_RS15210	COG0191	fructose-bisphosphate aldolase activity
VAPA_RS15215	COG0126	phosphoglycerate kinase activity
VAPA_RS15220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAPA_RS15225	COG3954	Phosphoribulokinase
VAPA_RS15230	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VAPA_RS15240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VAPA_RS15250	COG0464	growth
VAPA_RS15260	COG1850	ribulose-bisphosphate carboxylase activity
VAPA_RS15265	COG0583	DNA-binding transcription factor activity
VAPA_RS15305	COG2010	Cytochrome c
VAPA_RS15335	COG0714	Associated with various cellular activities
VAPA_RS15365	COG0535	radical SAM domain protein
VAPA_RS15380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VAPA_RS15395	COG2197	response regulator
VAPA_RS15405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAPA_RS15405	COG0512	Glutamine amidotransferase of anthranilate synthase
VAPA_RS15420	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
VAPA_RS15425	COG1229	Formylmethanofuran dehydrogenase subunit A
VAPA_RS15475	COG3284	Transcriptional regulator
VAPA_RS15485	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
VAPA_RS15500	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
VAPA_RS15510	COG0702	epimerase
VAPA_RS15545	COG0527	aspartate kinase activity
VAPA_RS15550	COG0037	tRNA processing
VAPA_RS15555	COG0825	malonyl-CoA metabolic process
VAPA_RS15565	COG0215	cysteine-tRNA ligase activity
VAPA_RS15585	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPA_RS15610	COG0741	lytic transglycosylase activity
VAPA_RS15615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAPA_RS15620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAPA_RS15655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAPA_RS15655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAPA_RS15670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VAPA_RS15675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAPA_RS15680	COG0436	Aminotransferase
VAPA_RS15685	COG0824	Thioesterase
VAPA_RS15695	COG0848	biopolymer transport protein
VAPA_RS15710	COG1054	Belongs to the UPF0176 family
VAPA_RS15735	COG1741	Belongs to the pirin family
VAPA_RS15750	COG1741	Belongs to the pirin family
VAPA_RS15760	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAPA_RS15760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_RS15765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAPA_RS15770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VAPA_RS15780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_RS15800	COG3976	FMN-binding domain protein
VAPA_RS15800	COG0431	NADPH-dependent FMN reductase
VAPA_RS15800	COG1053	succinate dehydrogenase
VAPA_RS15810	COG0235	Class ii aldolase
VAPA_RS15865	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VAPA_RS15875	COG0647	UMP catabolic process
VAPA_RS15880	COG1737	Transcriptional regulator
VAPA_RS15920	COG3842	ATPase activity
VAPA_RS15940	COG2205	protein histidine kinase activity
VAPA_RS15940	COG2198	Histidine kinase
VAPA_RS15940	COG0784	Response regulator, receiver
VAPA_RS15945	COG3437	response regulator, receiver
VAPA_RS15975	COG2207	Transcriptional regulator
VAPA_RS15995	COG0308	aminopeptidase N
VAPA_RS16035	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_RS16040	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
VAPA_RS16045	COG0028	Belongs to the TPP enzyme family
VAPA_RS16050	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS16055	COG1414	Transcriptional regulator
VAPA_RS16060	COG2267	carboxylic ester hydrolase activity
VAPA_RS16070	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS16075	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS16080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_RS16085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPA_RS16090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAPA_RS16100	COG4716	Myosin-crossreactive antigen
VAPA_RS16200	COG1596	polysaccharide export
VAPA_RS16205	COG0489	protein tyrosine kinase activity
VAPA_RS16205	COG3206	protein involved in exopolysaccharide biosynthesis
VAPA_RS16210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAPA_RS16215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPA_RS16245	COG0297	glycogen (starch) synthase activity
VAPA_RS16250	COG2197	response regulator
VAPA_RS16280	COG0587	DNA-directed DNA polymerase activity
VAPA_RS16310	COG0129	dihydroxy-acid dehydratase activity
VAPA_RS16350	COG3384	dioxygenase
VAPA_RS16360	COG1132	(ABC) transporter
VAPA_RS16370	COG1309	transcriptional regulator
VAPA_RS16385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VAPA_RS16395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_RS16400	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
VAPA_RS16405	COG2080	2 iron, 2 sulfur cluster binding
VAPA_RS16420	COG1272	protein, Hemolysin III
VAPA_RS16430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAPA_RS16440	COG0640	Transcriptional regulator
VAPA_RS16450	COG1183	phosphatidylcholine synthase activity
VAPA_RS16455	COG0625	glutathione transferase activity
VAPA_RS16480	COG1360	Flagellar Motor Protein
VAPA_RS16510	COG2818	Glycosylase
VAPA_RS16520	COG2079	MmgE PrpD family protein
VAPA_RS16545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAPA_RS16550	COG0583	DNA-binding transcription factor activity
VAPA_RS16555	COG0583	DNA-binding transcription factor activity
VAPA_RS16560	COG2223	nitrite transmembrane transporter activity
VAPA_RS16570	COG1024	Enoyl-CoA hydratase
VAPA_RS16600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS16630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPA_RS16635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS16640	COG0583	DNA-binding transcription factor activity
VAPA_RS16660	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VAPA_RS16665	COG0545	Peptidyl-prolyl cis-trans isomerase
VAPA_RS16670	COG0531	amino acid
VAPA_RS16675	COG4303	Ethanolamine ammonia lyase large subunit
VAPA_RS16680	COG4302	ethanolamine ammonia-lyase activity
VAPA_RS16710	COG0671	phosphoesterase, PA-phosphatase related
VAPA_RS16720	COG0745	RESPONSE REGULATOR receiver
VAPA_RS16725	COG0642	Histidine kinase
VAPA_RS16730	COG0824	Thioesterase
VAPA_RS16735	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS16750	COG2814	Major facilitator Superfamily
VAPA_RS16755	COG4336	lyase activity
VAPA_RS16765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPA_RS16770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS16780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPA_RS16780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_RS16790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VAPA_RS16795	COG0509	glycine decarboxylation via glycine cleavage system
VAPA_RS16800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAPA_RS16800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAPA_RS16825	COG2084	Dehydrogenase
VAPA_RS16830	COG3148	PFAM DTW domain containing protein
VAPA_RS16840	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VAPA_RS16860	COG0477	Major facilitator Superfamily
VAPA_RS16865	COG1082	Xylose isomerase domain protein TIM barrel
VAPA_RS16865	COG3185	4-Hydroxyphenylpyruvate dioxygenase
VAPA_RS16875	COG2814	Major facilitator Superfamily
VAPA_RS16880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VAPA_RS16885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAPA_RS16890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAPA_RS16895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS16900	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_RS16905	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPA_RS16910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAPA_RS16915	COG1414	Transcriptional regulator
VAPA_RS16925	COG0745	RESPONSE REGULATOR receiver
VAPA_RS16945	COG0583	DNA-binding transcription factor activity
VAPA_RS16960	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS16995	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VAPA_RS17005	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VAPA_RS17020	COG0640	Transcriptional regulator
VAPA_RS17030	COG4948	Mandelate Racemase Muconate Lactonizing
VAPA_RS17035	COG2271	Major facilitator Superfamily
VAPA_RS17040	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS17065	COG1294	oxidase, subunit
VAPA_RS17070	COG1271	oxidase subunit
VAPA_RS17075	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VAPA_RS17080	COG4988	ABC transporter
VAPA_RS17095	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS17110	COG1511	domain protein
VAPA_RS17110	COG3264	Mechanosensitive ion channel
VAPA_RS17120	COG0714	Associated with various cellular activities
VAPA_RS17135	COG2951	lytic endotransglycosylase activity
VAPA_RS17165	COG1131	(ABC) transporter
VAPA_RS17200	COG0395	ABC-type sugar transport system, permease component
VAPA_RS17210	COG3842	ATPase activity
VAPA_RS17215	COG3842	ATPase activity
VAPA_RS17235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VAPA_RS17255	COG2308	Evidence 4 Homologs of previously reported genes of
VAPA_RS17275	COG1305	Transglutaminase-like
VAPA_RS17285	COG4585	Histidine kinase
VAPA_RS17290	COG2197	response regulator
VAPA_RS17315	COG0583	DNA-binding transcription factor activity
VAPA_RS17325	COG1024	Enoyl-CoA hydratase
VAPA_RS17340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS17355	COG1609	Transcriptional regulator
VAPA_RS17365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAPA_RS17375	COG1126	abc transporter atp-binding protein
VAPA_RS17380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_RS17385	COG0765	amino acid transport
VAPA_RS17390	COG0765	amino acid transport
VAPA_RS17430	COG0739	heme binding
VAPA_RS17430	COG0741	lytic transglycosylase activity
VAPA_RS17430	COG1196	nuclear chromosome segregation
VAPA_RS17450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_RS17455	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VAPA_RS17460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VAPA_RS17475	COG2850	peptidyl-arginine hydroxylation
VAPA_RS17480	COG1047	Peptidyl-prolyl cis-trans
VAPA_RS17490	COG0756	dUTP diphosphatase activity
VAPA_RS17500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VAPA_RS17505	COG0504	CTP synthase activity
VAPA_RS17510	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAPA_RS17520	COG0148	phosphopyruvate hydratase activity
VAPA_RS17525	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VAPA_RS17530	COG3201	nicotinamide mononucleotide transporter
VAPA_RS17545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VAPA_RS17555	COG2833	Protein of unknown function (DUF455)
VAPA_RS17565	COG0183	Belongs to the thiolase family
VAPA_RS17575	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS17580	COG4974	Belongs to the 'phage' integrase family
VAPA_RS17585	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS17595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VAPA_RS17600	COG0802	atpase or kinase
VAPA_RS17605	COG0860	N-Acetylmuramoyl-L-alanine amidase
VAPA_RS17615	COG0586	Pfam SNARE associated Golgi protein
VAPA_RS17625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VAPA_RS17635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VAPA_RS17640	COG4181	ATPase activity
VAPA_RS17655	COG5285	phytanoyl-CoA dioxygenase
VAPA_RS17665	COG3795	YCII-related domain
VAPA_RS17670	COG4941	Belongs to the sigma-70 factor family
VAPA_RS17680	COG0577	efflux transmembrane transporter activity
VAPA_RS17745	COG1566	PFAM secretion protein HlyD family protein
VAPA_RS17755	COG1846	Transcriptional regulator
VAPA_RS17760	COG1132	(ABC) transporter
VAPA_RS17770	COG0494	nUDIX hydrolase
VAPA_RS17780	COG1007	ATP synthesis coupled electron transport
VAPA_RS17795	COG0713	ATP synthesis coupled electron transport
VAPA_RS17805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_RS17810	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VAPA_RS17815	COG1034	ATP synthesis coupled electron transport
VAPA_RS17830	COG0649	NAD binding
VAPA_RS17835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_RS17840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_RS17845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPA_RS17860	COG0149	triose-phosphate isomerase activity
VAPA_RS17870	COG1185	polyribonucleotide nucleotidyltransferase activity
VAPA_RS17875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VAPA_RS17880	COG0436	Aminotransferase
VAPA_RS17885	COG0683	leucine binding
VAPA_RS17900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VAPA_RS17905	COG3707	response regulator
VAPA_RS17910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS17915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS17920	COG1116	anion transmembrane transporter activity
VAPA_RS17930	COG2223	nitrite transmembrane transporter activity
VAPA_RS17935	COG0515	serine threonine protein kinase
VAPA_RS17935	COG2815	serine threonine protein kinase
VAPA_RS17940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAPA_RS17950	COG0243	molybdopterin cofactor binding
VAPA_RS17955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAPA_RS17975	COG3842	ATPase activity
VAPA_RS17985	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPA_RS17990	COG3833	ABC-type maltose transport systems, permease component
VAPA_RS18000	COG0791	NLP P60 protein
VAPA_RS18005	COG2081	HI0933 family
VAPA_RS18010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VAPA_RS18015	COG1610	YqeY-like protein
VAPA_RS18020	COG0494	nUDIX hydrolase
VAPA_RS18055	COG1672	PFAM Archaeal ATPase
VAPA_RS18055	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VAPA_RS18070	COG0405	Gamma-glutamyltransferase
VAPA_RS18075	COG0583	DNA-binding transcription factor activity
VAPA_RS18090	COG0312	modulator of DNA gyrase
VAPA_RS18095	COG3028	Belongs to the UPF0307 family
VAPA_RS18100	COG0521	Mo-molybdopterin cofactor biosynthetic process
VAPA_RS18140	COG0475	glutathione-regulated potassium exporter activity
VAPA_RS18160	COG0789	Transcriptional regulator
VAPA_RS18165	COG1045	serine acetyltransferase
VAPA_RS18175	COG0483	inositol monophosphate 1-phosphatase activity
VAPA_RS18180	COG1289	transmembrane transporter activity
VAPA_RS18190	COG1522	sequence-specific DNA binding
VAPA_RS18200	COG2311	Membrane
VAPA_RS18205	COG0583	DNA-binding transcription factor activity
VAPA_RS18215	COG1846	Transcriptional regulator
VAPA_RS18230	COG3119	arylsulfatase activity
VAPA_RS18255	COG1858	cytochrome C peroxidase
VAPA_RS18275	COG2375	cellular response to nickel ion
VAPA_RS18280	COG0598	Magnesium transport protein CorA
VAPA_RS18290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VAPA_RS18330	COG0601	transmembrane transport
VAPA_RS18335	COG0747	negative chemotaxis
VAPA_RS18365	COG1968	undecaprenyl-diphosphatase activity
VAPA_RS18375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_RS18380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAPA_RS18385	COG1737	Transcriptional regulator
VAPA_RS18400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_RS18405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_RS18410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_RS18425	COG2972	Histidine kinase
VAPA_RS18440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAPA_RS18460	COG0004	ammonium transporteR
VAPA_RS18465	COG3279	Response regulator of the LytR AlgR family
VAPA_RS18490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VAPA_RS18510	COG0789	Transcriptional regulator
VAPA_RS18520	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS18525	COG2201	protein-glutamate methylesterase activity
VAPA_RS18530	COG2918	glutathione biosynthetic process
VAPA_RS18550	COG0523	cobalamin synthesis protein
VAPA_RS18595	COG2354	Protein conserved in bacteria
VAPA_RS18605	COG4628	conserved protein (DUF2132)
VAPA_RS18620	COG0564	pseudouridine synthase activity
VAPA_RS18640	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
VAPA_RS18645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAPA_RS18650	COG1252	NADH dehydrogenase
VAPA_RS18665	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS18670	COG1764	response to oxidative stress
VAPA_RS18690	COG0765	amino acid transport
VAPA_RS18695	COG0765	amino acid transport
VAPA_RS18710	COG0583	DNA-binding transcription factor activity
VAPA_RS18730	COG0584	glycerophosphoryl diester phosphodiesterase
VAPA_RS18750	COG3191	aminopeptidase activity
VAPA_RS18770	COG0488	(ABC) transporter
VAPA_RS18775	COG0513	Belongs to the DEAD box helicase family
VAPA_RS18795	COG3842	ATPase activity
VAPA_RS18805	COG1175	transmembrane transport
VAPA_RS18815	COG2186	Transcriptional regulator
VAPA_RS18820	COG0129	dihydroxy-acid dehydratase activity
VAPA_RS18825	COG3734	2-keto-3-deoxy-galactonokinase
VAPA_RS18830	COG0800	Aldolase
VAPA_RS18845	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS18875	COG1840	ABC-type Fe3 transport system, periplasmic component
VAPA_RS18885	COG3842	ATPase activity
VAPA_RS18895	COG0346	lactoylglutathione lyase activity
VAPA_RS18905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAPA_RS18915	COG0800	Aldolase
VAPA_RS18940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAPA_RS18945	COG0259	pyridoxamine-phosphate oxidase activity
VAPA_RS18960	COG0679	Auxin Efflux Carrier
VAPA_RS18975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAPA_RS18980	COG1309	transcriptional regulator
VAPA_RS18985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAPA_RS19010	COG2169	Transcriptional regulator
VAPA_RS19020	COG0697	spore germination
VAPA_RS19040	COG0625	glutathione transferase activity
VAPA_RS19070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VAPA_RS19085	COG4774	siderophore transport
VAPA_RS19125	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
VAPA_RS19165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPA_RS19190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAPA_RS19215	COG0285	dihydrofolate synthase activity
VAPA_RS19220	COG1393	Belongs to the ArsC family
VAPA_RS19230	COG3123	guanosine phosphorylase activity
VAPA_RS19235	COG0137	argininosuccinate synthase activity
VAPA_RS19245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VAPA_RS19250	COG1666	GTP binding
VAPA_RS19260	COG0251	oxidation-reduction process
VAPA_RS19265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VAPA_RS19270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VAPA_RS19275	COG0667	Aldo Keto reductase
VAPA_RS19295	COG1464	Belongs to the NlpA lipoprotein family
VAPA_RS19300	COG2011	ABC-type metal ion transport system permease component
VAPA_RS19310	COG1464	Belongs to the NlpA lipoprotein family
VAPA_RS19315	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAPA_RS19320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAPA_RS19325	COG0308	aminopeptidase N
VAPA_RS19330	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VAPA_RS19360	COG2080	2 iron, 2 sulfur cluster binding
VAPA_RS19365	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
VAPA_RS19370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_RS19375	COG3386	PFAM SMP-30 Gluconolaconase
VAPA_RS19380	COG3302	dmso reductase anchor subunit
VAPA_RS19385	COG0437	4 iron, 4 sulfur cluster binding
VAPA_RS19390	COG0243	molybdopterin cofactor binding
VAPA_RS19395	COG0583	DNA-binding transcription factor activity
VAPA_RS19410	COG2721	sulfolactate sulfo-lyase activity
VAPA_RS19415	COG2721	sulfolactate sulfo-lyase activity
VAPA_RS19420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_RS19425	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VAPA_RS19435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAPA_RS19445	COG1414	Transcriptional regulator
VAPA_RS19470	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_RS19475	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS19490	COG1414	Transcriptional regulator
VAPA_RS19495	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
VAPA_RS19500	COG0477	Major facilitator Superfamily
VAPA_RS19505	COG2771	luxR family
VAPA_RS19525	COG2010	Cytochrome c
VAPA_RS19525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_RS19530	COG0583	DNA-binding transcription factor activity
VAPA_RS19535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS19540	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
VAPA_RS19545	COG4521	taurine ABC transporter
VAPA_RS19550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_RS19575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_RS19580	COG0444	Belongs to the ABC transporter superfamily
VAPA_RS19585	COG4608	Belongs to the ABC transporter superfamily
VAPA_RS19590	COG1228	amidohydrolase
VAPA_RS19620	COG1253	flavin adenine dinucleotide binding
VAPA_RS19625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VAPA_RS19660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS19670	COG1116	anion transmembrane transporter activity
VAPA_RS19675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS19680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS19690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPA_RS19700	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS19705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPA_RS19725	COG0513	Belongs to the DEAD box helicase family
VAPA_RS19730	COG2321	neutral zinc metallopeptidase
VAPA_RS19735	COG0717	Belongs to the dCTP deaminase family
VAPA_RS19740	COG0402	S-adenosylhomocysteine deaminase activity
VAPA_RS19755	COG0583	DNA-binding transcription factor activity
VAPA_RS19765	COG2366	antibiotic biosynthetic process
VAPA_RS19770	COG4977	sequence-specific DNA binding
VAPA_RS19775	COG0583	DNA-binding transcription factor activity
VAPA_RS19780	COG2814	Major facilitator Superfamily
VAPA_RS19785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAPA_RS19790	COG4654	Cytochrome c, class I
VAPA_RS19800	COG0604	alcohol dehydrogenase
VAPA_RS19835	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS19840	COG2301	Belongs to the HpcH HpaI aldolase family
VAPA_RS19845	COG0583	DNA-binding transcription factor activity
VAPA_RS19860	COG4603	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS19865	COG3845	ABC transporter
VAPA_RS19870	COG2252	PERMEase
VAPA_RS19880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPA_RS19900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAPA_RS19915	COG3344	reverse transcriptase
VAPA_RS19940	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS20005	COG2186	Transcriptional regulator
VAPA_RS20020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPA_RS20025	COG1802	Transcriptional regulator
VAPA_RS20035	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPA_RS20040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPA_RS20045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS20065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_RS20075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_RS20095	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS20105	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS20115	COG1953	Uracil, thiamine, allantoin
VAPA_RS20135	COG1309	transcriptional regulator
VAPA_RS20150	COG2233	PERMEase
VAPA_RS20155	COG0656	L-ascorbic acid biosynthetic process
VAPA_RS20165	COG4566	intracellular signal transduction
VAPA_RS20170	COG0477	Major facilitator Superfamily
VAPA_RS20185	COG1301	dicarboxylic acid transport
VAPA_RS20195	COG0628	permease
VAPA_RS20210	COG0583	DNA-binding transcription factor activity
VAPA_RS20215	COG3960	tartronate-semialdehyde synthase activity
VAPA_RS20220	COG3622	Belongs to the hyi family
VAPA_RS20225	COG2084	Dehydrogenase
VAPA_RS20235	COG0281	malic enzyme
VAPA_RS20235	COG0280	phosphate acetyltransferase
VAPA_RS20240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_RS20255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS20265	COG1116	anion transmembrane transporter activity
VAPA_RS20270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS20310	COG1733	regulation of RNA biosynthetic process
VAPA_RS20325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPA_RS20345	COG0829	nickel cation binding
VAPA_RS20350	COG0583	DNA-binding transcription factor activity
VAPA_RS20365	COG0583	DNA-binding transcription factor activity
VAPA_RS20410	COG2879	small protein
VAPA_RS20415	COG1966	Carbon starvation protein
VAPA_RS20430	COG0791	NLP P60 protein
VAPA_RS20485	COG0667	Aldo Keto reductase
VAPA_RS20490	COG3540	Alkaline phosphatase
VAPA_RS20495	COG0584	glycerophosphoryl diester phosphodiesterase
VAPA_RS20500	COG0395	ABC-type sugar transport system, permease component
VAPA_RS20505	COG1175	transmembrane transport
VAPA_RS20520	COG2390	Transcriptional regulator
VAPA_RS20525	COG2814	Major facilitator Superfamily
VAPA_RS20555	COG0477	Major facilitator Superfamily
VAPA_RS20585	COG0613	PHP domain protein
VAPA_RS20595	COG0009	L-threonylcarbamoyladenylate synthase
VAPA_RS20600	COG1994	Peptidase M50
VAPA_RS20605	COG0180	Tryptophanyl-tRNA synthetase
VAPA_RS20610	COG2197	response regulator
VAPA_RS20625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VAPA_RS20630	COG2764	glyoxalase bleomycin resistance protein dioxygenase
VAPA_RS20635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAPA_RS20640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VAPA_RS20645	COG1047	Peptidyl-prolyl cis-trans
VAPA_RS20650	COG2003	Belongs to the UPF0758 family
VAPA_RS20670	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAPA_RS20680	COG0765	amino acid transport
VAPA_RS20685	COG0765	amino acid transport
VAPA_RS20695	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
VAPA_RS20700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAPA_RS20705	COG0477	Major facilitator Superfamily
VAPA_RS20710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VAPA_RS20715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPA_RS20720	COG1845	cytochrome c oxidase, subunit III
VAPA_RS20725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VAPA_RS20740	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
VAPA_RS20745	COG1272	protein, Hemolysin III
VAPA_RS20750	COG2900	Belongs to the SlyX family
VAPA_RS20755	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS20765	COG0583	DNA-binding transcription factor activity
VAPA_RS20770	COG0477	Major facilitator Superfamily
VAPA_RS20775	COG0583	DNA-binding transcription factor activity
VAPA_RS20785	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VAPA_RS20790	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAPA_RS20810	COG0437	4 iron, 4 sulfur cluster binding
VAPA_RS20815	COG0243	molybdopterin cofactor binding
VAPA_RS20815	COG3383	formate dehydrogenase (NAD+) activity
VAPA_RS20850	COG0725	ABC transporter, periplasmic molybdate-binding protein
VAPA_RS20855	COG4149	molybdate abc transporter
VAPA_RS20865	COG3383	formate dehydrogenase (NAD+) activity
VAPA_RS20875	COG0583	DNA-binding transcription factor activity
VAPA_RS20880	COG0489	protein tyrosine kinase activity
VAPA_RS20905	COG3132	Protein of unknown function, DUF480
VAPA_RS20910	COG3698	Phosphodiester glycosidase
VAPA_RS20915	COG0473	3-isopropylmalate dehydrogenase activity
VAPA_RS20920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAPA_RS20920	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAPA_RS20950	COG0659	secondary active sulfate transmembrane transporter activity
VAPA_RS20960	COG3293	Transposase
VAPA_RS20980	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VAPA_RS20985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VAPA_RS20990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VAPA_RS20995	COG0602	queuosine metabolic process
VAPA_RS21005	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VAPA_RS21015	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAPA_RS21020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VAPA_RS21030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAPA_RS21035	COG0588	phosphoglycerate mutase activity
VAPA_RS21040	COG0793	Belongs to the peptidase S41A family
VAPA_RS21045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VAPA_RS21050	COG2982	Protein involved in outer membrane biogenesis
VAPA_RS21060	COG2197	response regulator
VAPA_RS21065	COG4585	Histidine kinase
VAPA_RS21095	COG2823	Periplasmic or secreted lipoprotein
VAPA_RS21120	COG3568	Endonuclease Exonuclease Phosphatase
VAPA_RS21125	COG0494	nUDIX hydrolase
VAPA_RS21130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VAPA_RS21145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAPA_RS21150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VAPA_RS21165	COG2226	methyltransferase
VAPA_RS21185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_RS21195	COG1175	transmembrane transport
VAPA_RS21200	COG0395	ABC-type sugar transport system, permease component
VAPA_RS21205	COG3842	ATPase activity
VAPA_RS21210	COG0584	glycerophosphoryl diester phosphodiesterase
VAPA_RS21215	COG1511	domain protein
VAPA_RS21215	COG3264	Mechanosensitive ion channel
VAPA_RS21225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VAPA_RS21240	COG1191	sigma factor activity
VAPA_RS21250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAPA_RS21250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAPA_RS21275	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VAPA_RS21280	COG0745	RESPONSE REGULATOR receiver
VAPA_RS21290	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VAPA_RS21295	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAPA_RS21300	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAPA_RS21350	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VAPA_RS21355	COG1334	flagellar protein FlaG
VAPA_RS21365	COG1677	Flagellar hook-basal body complex protein FliE
VAPA_RS21380	COG1317	bacterial-type flagellum organization
VAPA_RS21390	COG2882	bacterial-type flagellum organization
VAPA_RS21400	COG1580	Controls the rotational direction of flagella during chemotaxis
VAPA_RS21420	COG1338	Plays a role in the flagellum-specific transport system
VAPA_RS21440	COG1256	bacterial-type flagellum assembly
VAPA_RS21445	COG0840	transmembrane signaling receptor activity
VAPA_RS21455	COG0835	chemotaxis
VAPA_RS21460	COG0840	transmembrane signaling receptor activity
VAPA_RS21465	COG0840	transmembrane signaling receptor activity
VAPA_RS21470	COG0840	transmembrane signaling receptor activity
VAPA_RS21480	COG0835	chemotaxis
VAPA_RS21485	COG1705	Flagellar rod assembly protein muramidase FlgJ
VAPA_RS21485	COG3951	Flagellar rod assembly protein muramidase FlgJ
VAPA_RS21490	COG1706	bacterial-type flagellum-dependent cell motility
VAPA_RS21495	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VAPA_RS21505	COG4787	bacterial-type flagellum-dependent cell motility
VAPA_RS21515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VAPA_RS21520	COG1558	bacterial-type flagellum-dependent cell motility
VAPA_RS21525	COG1815	bacterial-type flagellum-dependent cell motility
VAPA_RS21555	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VAPA_RS21560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VAPA_RS21565	COG2890	protein-(glutamine-N5) methyltransferase activity
VAPA_RS21570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VAPA_RS21580	COG1253	flavin adenine dinucleotide binding
VAPA_RS21585	COG0741	lytic transglycosylase activity
VAPA_RS21590	COG0442	prolyl-tRNA aminoacylation
VAPA_RS21595	COG0494	nUDIX hydrolase
VAPA_RS21605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VAPA_RS21610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VAPA_RS21615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VAPA_RS21620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VAPA_RS21625	COG0142	geranyltranstransferase activity
VAPA_RS21645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VAPA_RS21655	COG1696	Membrane protein involved in D-alanine export
VAPA_RS21665	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VAPA_RS21670	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VAPA_RS21675	COG2755	lipolytic protein G-D-S-L family
VAPA_RS21675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAPA_RS21680	COG0494	nUDIX hydrolase
VAPA_RS21690	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
VAPA_RS21695	COG0653	protein targeting
VAPA_RS21710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VAPA_RS21715	COG0583	DNA-binding transcription factor activity
VAPA_RS21735	COG0784	Response regulator, receiver
VAPA_RS21735	COG5002	protein histidine kinase activity
VAPA_RS21735	COG2205	protein histidine kinase activity
VAPA_RS21740	COG0831	urea catabolic process
VAPA_RS21750	COG0832	Belongs to the urease beta subunit family
VAPA_RS21755	COG0804	urea catabolic process
VAPA_RS21770	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
VAPA_RS21775	COG0830	nickel cation binding
VAPA_RS21780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VAPA_RS21810	COG0745	RESPONSE REGULATOR receiver
VAPA_RS21825	COG2205	protein histidine kinase activity
VAPA_RS21830	COG0745	RESPONSE REGULATOR receiver
VAPA_RS21840	COG2982	Protein involved in outer membrane biogenesis
VAPA_RS21895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS22130	COG0582	viral genome integration into host DNA
VAPA_RS22140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAPA_RS22145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VAPA_RS22160	COG2815	serine threonine protein kinase
VAPA_RS22160	COG0515	serine threonine protein kinase
VAPA_RS22165	COG1561	YicC-like family, N-terminal region
VAPA_RS22170	COG0194	GDP metabolic process
VAPA_RS22175	COG1758	RNA polymerase activity
VAPA_RS22180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAPA_RS22195	COG0529	Catalyzes the synthesis of activated sulfate
VAPA_RS22210	COG1420	regulation of RNA biosynthetic process
VAPA_RS22215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VAPA_RS22220	COG0497	DNA recombination
VAPA_RS22225	COG1660	Displays ATPase and GTPase activities
VAPA_RS22235	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
VAPA_RS22240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAPA_RS22255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VAPA_RS22265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VAPA_RS22270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VAPA_RS22275	COG0193	aminoacyl-tRNA hydrolase activity
VAPA_RS22285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAPA_RS22295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_RS22305	COG4608	Belongs to the ABC transporter superfamily
VAPA_RS22310	COG0747	negative chemotaxis
VAPA_RS22315	COG0747	negative chemotaxis
VAPA_RS22320	COG0154	amidase activity
VAPA_RS22340	COG0583	DNA-binding transcription factor activity
VAPA_RS22355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VAPA_RS22370	COG2267	carboxylic ester hydrolase activity
VAPA_RS22375	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VAPA_RS22385	COG1984	allophanate hydrolase subunit 2
VAPA_RS22390	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VAPA_RS22395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VAPA_RS22400	COG0742	ribosomal rna small subunit methyltransferase
VAPA_RS22415	COG0612	Peptidase, M16
VAPA_RS22420	COG0612	Peptidase, M16
VAPA_RS22440	COG2197	response regulator
VAPA_RS22450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAPA_RS22455	COG4335	DNA alkylation repair
VAPA_RS22460	COG1999	signal sequence binding
VAPA_RS22465	COG0109	protoheme IX farnesyltransferase activity
VAPA_RS22500	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VAPA_RS22505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPA_RS22520	COG2226	methyltransferase
VAPA_RS22525	COG1040	competence protein
VAPA_RS22530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VAPA_RS22540	COG0489	protein tyrosine kinase activity
VAPA_RS22560	COG1024	Enoyl-CoA hydratase
VAPA_RS22565	COG1022	Amp-dependent synthetase and ligase
VAPA_RS22565	COG3320	Male sterility
VAPA_RS22580	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS22595	COG2764	glyoxalase bleomycin resistance protein dioxygenase
VAPA_RS22615	COG5507	3-demethylubiquinone-9 3-methyltransferase
VAPA_RS22635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VAPA_RS22640	COG0430	RNA-3'-phosphate cyclase activity
VAPA_RS22650	COG1690	Belongs to the RtcB family
VAPA_RS22660	COG4650	regulator
VAPA_RS22670	COG1073	alpha beta
VAPA_RS22675	COG2423	ornithine cyclodeaminase activity
VAPA_RS22695	COG1764	response to oxidative stress
VAPA_RS22725	COG0183	Belongs to the thiolase family
VAPA_RS22730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
VAPA_RS22740	COG1414	Transcriptional regulator
VAPA_RS22755	COG3063	Type IV pilus biogenesis stability protein PilW
VAPA_RS22775	COG4964	Belongs to the GSP D family
VAPA_RS22830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_RS22835	COG2274	protein secretion by the type I secretion system
VAPA_RS22845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAPA_RS22865	COG0583	DNA-binding transcription factor activity
VAPA_RS22870	COG3485	protocatechuate 3,4-dioxygenase
VAPA_RS22875	COG3485	protocatechuate 3,4-dioxygenase
VAPA_RS22885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPA_RS22940	COG0469	pyruvate kinase activity
VAPA_RS22945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPA_RS22955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VAPA_RS22960	COG0045	succinate-CoA ligase (ADP-forming) activity
VAPA_RS22970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS22975	COG4191	Histidine kinase
VAPA_RS23025	COG0582	viral genome integration into host DNA
VAPA_RS23040	COG0714	Associated with various cellular activities
VAPA_RS23045	COG3831	ATPase activity
VAPA_RS23055	COG3552	Protein containing von Willebrand factor type A (VWA) domain
VAPA_RS23155	COG2274	protein secretion by the type I secretion system
VAPA_RS23175	COG0745	RESPONSE REGULATOR receiver
VAPA_RS23185	COG2205	protein histidine kinase activity
VAPA_RS23195	COG4804	nuclease activity
VAPA_RS23245	COG0514	ATP-dependent DNA helicase (RecQ)
VAPA_RS23260	COG0582	viral genome integration into host DNA
VAPA_RS23265	COG1431	PFAM Stem cell self-renewal protein Piwi
VAPA_RS23305	COG1484	DNA-dependent DNA replication
VAPA_RS23310	COG2207	Transcriptional regulator
VAPA_RS23330	COG0540	Belongs to the ATCase OTCase family
VAPA_RS23335	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VAPA_RS23340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VAPA_RS23345	COG1678	Uncharacterized ACR, COG1678
VAPA_RS23350	COG0415	Belongs to the DNA photolyase family
VAPA_RS23365	COG0784	Response regulator, receiver
VAPA_RS23365	COG2198	Histidine kinase
VAPA_RS23365	COG0643	Histidine kinase
VAPA_RS23370	COG0840	transmembrane signaling receptor activity
VAPA_RS23390	COG1773	rubredoxin
VAPA_RS23400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VAPA_RS23405	COG0154	amidase activity
VAPA_RS23420	COG0138	bifunctional purine biosynthesis protein purh
VAPA_RS23435	COG1238	metal cluster binding
VAPA_RS23445	COG0012	GTP binding
VAPA_RS23450	COG1879	ABC-type sugar transport system periplasmic component
VAPA_RS23455	COG1129	ABC transporter
VAPA_RS23460	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS23470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAPA_RS23475	COG1869	D-ribose catabolic process
VAPA_RS23485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_RS23500	COG1024	Enoyl-CoA hydratase
VAPA_RS23525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPA_RS23535	COG2863	cytochrome
VAPA_RS23540	COG2010	Cytochrome c
VAPA_RS23550	COG1230	cation diffusion facilitator family transporter
VAPA_RS23555	COG2255	four-way junction helicase activity
VAPA_RS23560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VAPA_RS23565	COG2267	carboxylic ester hydrolase activity
VAPA_RS23570	COG2453	phosphatase
VAPA_RS23570	COG0671	phosphoesterase, PA-phosphatase related
VAPA_RS23585	COG4589	Belongs to the CDS family
VAPA_RS23605	COG1042	CoA-binding domain protein
VAPA_RS23605	COG0045	succinate-CoA ligase (ADP-forming) activity
VAPA_RS23605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAPA_RS23630	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS23635	COG0632	four-way junction helicase activity
VAPA_RS23640	COG1702	phosphate starvation-inducible protein PhoH
VAPA_RS23645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VAPA_RS23650	COG1490	D-aminoacyl-tRNA deacylase activity
VAPA_RS23655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VAPA_RS23670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAPA_RS23675	COG0739	heme binding
VAPA_RS23680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VAPA_RS23685	COG2814	Major facilitator Superfamily
VAPA_RS23690	COG0316	Belongs to the HesB IscA family
VAPA_RS23695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VAPA_RS23700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VAPA_RS23705	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VAPA_RS23710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAPA_RS23725	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VAPA_RS23750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VAPA_RS23765	COG4555	ABC transporter
VAPA_RS23785	COG2423	ornithine cyclodeaminase activity
VAPA_RS23795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VAPA_RS23800	COG3842	ATPase activity
VAPA_RS23810	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPA_RS23815	COG1177	transmembrane transport
VAPA_RS23825	COG1012	belongs to the aldehyde dehydrogenase family
VAPA_RS23830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAPA_RS23845	COG0477	Major facilitator Superfamily
VAPA_RS23870	COG1254	Belongs to the acylphosphatase family
VAPA_RS23880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS23895	COG1414	Transcriptional regulator
VAPA_RS23900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_RS23920	COG1024	Enoyl-CoA hydratase
VAPA_RS23925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAPA_RS23930	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS23935	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS23950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAPA_RS23975	COG0789	Transcriptional regulator
VAPA_RS23980	COG0288	reversible hydration of carbon dioxide
VAPA_RS23985	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
VAPA_RS23990	COG0183	Belongs to the thiolase family
VAPA_RS24000	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS24005	COG3012	SEC-C Motif Domain Protein
VAPA_RS24010	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VAPA_RS24025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAPA_RS24030	COG0751	glycine-tRNA ligase activity
VAPA_RS24035	COG0752	glycyl-tRNA synthetase alpha subunit
VAPA_RS24040	COG1597	lipid kinase activity
VAPA_RS24045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VAPA_RS24050	COG0671	phosphoesterase, PA-phosphatase related
VAPA_RS24070	COG0288	reversible hydration of carbon dioxide
VAPA_RS24080	COG0583	DNA-binding transcription factor activity
VAPA_RS24085	COG2814	Major facilitator Superfamily
VAPA_RS24125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS24135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VAPA_RS24140	COG4535	Mg2 and Co2 transporter CorC
VAPA_RS24150	COG1522	sequence-specific DNA binding
VAPA_RS24165	COG3186	Phenylalanine-4-hydroxylase
VAPA_RS24170	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS24230	COG0488	(ABC) transporter
VAPA_RS24235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPA_RS24280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_RS24315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAPA_RS24330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VAPA_RS24335	COG0439	Biotin carboxylase
VAPA_RS24340	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS24385	COG1505	serine-type exopeptidase activity
VAPA_RS24415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VAPA_RS24455	COG2084	Dehydrogenase
VAPA_RS24465	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAPA_RS24470	COG0792	nuclease activity
VAPA_RS24475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAPA_RS24490	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS24505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VAPA_RS24510	COG0583	DNA-binding transcription factor activity
VAPA_RS24515	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS24545	COG1309	transcriptional regulator
VAPA_RS24550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPA_RS24555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPA_RS24585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPA_RS24590	COG1335	isochorismatase
VAPA_RS24595	COG0251	oxidation-reduction process
VAPA_RS24600	COG2267	carboxylic ester hydrolase activity
VAPA_RS24605	COG0778	Nitroreductase
VAPA_RS24610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPA_RS24615	COG1309	transcriptional regulator
VAPA_RS24635	COG3845	ABC transporter
VAPA_RS24645	COG1079	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS24655	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
VAPA_RS24660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAPA_RS24665	COG3842	ATPase activity
VAPA_RS24670	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPA_RS24675	COG1177	transmembrane transport
VAPA_RS24705	COG3118	belongs to the thioredoxin family
VAPA_RS24710	COG1201	RNA secondary structure unwinding
VAPA_RS24715	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAPA_RS24715	COG1793	dna ligase
VAPA_RS24720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAPA_RS24720	COG1793	dna ligase
VAPA_RS24750	COG1116	anion transmembrane transporter activity
VAPA_RS24775	COG0673	inositol 2-dehydrogenase activity
VAPA_RS24780	COG1879	ABC-type sugar transport system periplasmic component
VAPA_RS24785	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS24805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VAPA_RS24810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VAPA_RS24815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VAPA_RS24820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VAPA_RS24825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VAPA_RS24830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VAPA_RS24840	COG0356	it plays a direct role in the translocation of protons across the membrane
VAPA_RS24855	COG2921	Belongs to the UPF0250 family
VAPA_RS24860	COG0321	lipoyl(octanoyl) transferase activity
VAPA_RS24865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VAPA_RS24870	COG0477	Major facilitator Superfamily
VAPA_RS24875	COG0583	DNA-binding transcription factor activity
VAPA_RS24880	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS24885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VAPA_RS24905	COG2130	NADP-dependent
VAPA_RS24910	COG2205	protein histidine kinase activity
VAPA_RS24915	COG0745	RESPONSE REGULATOR receiver
VAPA_RS24935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VAPA_RS24940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAPA_RS24950	COG2814	Major facilitator Superfamily
VAPA_RS24960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAPA_RS24970	COG0678	peroxiredoxin activity
VAPA_RS24975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VAPA_RS24980	COG0255	Belongs to the universal ribosomal protein uL29 family
VAPA_RS24985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VAPA_RS24990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VAPA_RS24995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VAPA_RS25000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VAPA_RS25005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VAPA_RS25010	COG0089	rRNA binding
VAPA_RS25015	COG0088	Forms part of the polypeptide exit tunnel
VAPA_RS25020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VAPA_RS25035	COG0051	transcription antitermination factor activity, RNA binding
VAPA_RS25040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAPA_RS25045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAPA_RS25050	COG0049	tRNA binding
VAPA_RS25055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VAPA_RS25060	COG1686	Belongs to the peptidase S11 family
VAPA_RS25065	COG2945	thiolester hydrolase activity
VAPA_RS25080	COG1981	membrane
VAPA_RS25090	COG0598	Magnesium transport protein CorA
VAPA_RS25100	COG0583	DNA-binding transcription factor activity
VAPA_RS25105	COG0412	Dienelactone hydrolase
VAPA_RS25115	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS25120	COG2095	MarC family integral membrane protein
VAPA_RS25155	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS25165	COG0657	acetylesterase activity
VAPA_RS25170	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VAPA_RS25175	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPA_RS25190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
VAPA_RS25195	COG1652	LysM domain
VAPA_RS25205	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAPA_RS25220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VAPA_RS25220	COG0574	Belongs to the PEP-utilizing enzyme family
VAPA_RS25235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPA_RS25245	COG4208	sulfate ABC transporter
VAPA_RS25270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAPA_RS25280	COG0640	Transcriptional regulator
VAPA_RS25285	COG2124	cytochrome p450
VAPA_RS25295	COG0625	glutathione transferase activity
VAPA_RS25300	COG0583	DNA-binding transcription factor activity
VAPA_RS25315	COG1131	(ABC) transporter
VAPA_RS25325	COG1846	Transcriptional regulator
VAPA_RS25330	COG1764	response to oxidative stress
VAPA_RS25340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAPA_RS25345	COG0583	DNA-binding transcription factor activity
VAPA_RS25350	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS25355	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS25360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS25375	COG0326	Molecular chaperone. Has ATPase activity
VAPA_RS25380	COG1840	ABC-type Fe3 transport system, periplasmic component
VAPA_RS25385	COG0583	DNA-binding transcription factor activity
VAPA_RS25395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VAPA_RS25405	COG0642	Histidine kinase
VAPA_RS25420	COG1187	pseudouridine synthase activity
VAPA_RS25425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAPA_RS25445	COG0745	RESPONSE REGULATOR receiver
VAPA_RS25450	COG2205	protein histidine kinase activity
VAPA_RS25455	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
VAPA_RS25460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
VAPA_RS25465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
VAPA_RS25480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VAPA_RS25505	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS25515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_RS25520	COG1022	Amp-dependent synthetase and ligase
VAPA_RS25550	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS25565	COG0693	protein deglycase activity
VAPA_RS25605	COG4993	Dehydrogenase
VAPA_RS25610	COG1940	carbohydrate kinase activity
VAPA_RS25615	COG1129	ABC transporter
VAPA_RS25620	COG4214	carbohydrate transport
VAPA_RS25625	COG4213	ABC transporter substrate-binding protein
VAPA_RS25635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPA_RS25640	COG0583	DNA-binding transcription factor activity
VAPA_RS25650	COG4774	siderophore transport
VAPA_RS25655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VAPA_RS25660	COG0022	dehydrogenase e1 component
VAPA_RS25670	COG1028	Short-chain dehydrogenase reductase Sdr
VAPA_RS25675	COG0583	DNA-binding transcription factor activity
VAPA_RS25680	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS25690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAPA_RS25705	COG1024	Enoyl-CoA hydratase
VAPA_RS25710	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS25730	COG0203	ribosomal protein L17
VAPA_RS25735	COG0202	RNA polymerase activity
VAPA_RS25740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VAPA_RS25745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VAPA_RS25750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VAPA_RS25755	COG0201	protein transport
VAPA_RS25760	COG0200	Binds to the 23S rRNA
VAPA_RS25765	COG1841	ribosomal large subunit assembly
VAPA_RS25770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VAPA_RS25775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VAPA_RS25780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VAPA_RS25785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VAPA_RS25790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VAPA_RS25795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VAPA_RS25800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VAPA_RS25805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VAPA_RS25820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VAPA_RS25825	COG0783	Belongs to the Dps family
VAPA_RS25835	COG1280	lysine exporter protein (LysE YggA)
VAPA_RS25840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VAPA_RS25845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VAPA_RS25850	COG3386	PFAM SMP-30 Gluconolaconase
VAPA_RS25855	COG0343	queuine tRNA-ribosyltransferase activity
VAPA_RS25910	COG0284	orotidine-5'-phosphate decarboxylase activity
VAPA_RS25925	COG1214	PFAM Peptidase M22, glycoprotease
VAPA_RS25940	COG0494	nUDIX hydrolase
VAPA_RS25945	COG2027	D-alanyl-D-alanine carboxypeptidase
VAPA_RS25955	COG0009	L-threonylcarbamoyladenylate synthase
VAPA_RS25960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VAPA_RS25965	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VAPA_RS25980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VAPA_RS25990	COG1522	sequence-specific DNA binding
VAPA_RS25995	COG2515	1-aminocyclopropane-1-carboxylate deaminase
VAPA_RS26000	COG0469	pyruvate kinase activity
VAPA_RS26005	COG0126	phosphoglycerate kinase activity
VAPA_RS26025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_RS26055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VAPA_RS26065	COG0242	peptide deformylase activity
VAPA_RS26075	COG0758	DNA mediated transformation
VAPA_RS26080	COG2922	Belongs to the Smg family
VAPA_RS26090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAPA_RS26095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAPA_RS26100	COG1862	Preprotein translocase
VAPA_RS26110	COG1522	sequence-specific DNA binding
VAPA_RS26120	COG0765	amino acid transport
VAPA_RS26125	COG2814	Major facilitator Superfamily
VAPA_RS26135	COG1845	cytochrome c oxidase, subunit III
VAPA_RS26145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPA_RS26150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VAPA_RS26170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPA_RS26200	COG0251	oxidation-reduction process
VAPA_RS26210	COG3622	Belongs to the hyi family
VAPA_RS26215	COG0235	Class ii aldolase
VAPA_RS26220	COG3395	kinase activity
VAPA_RS26225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPA_RS26230	COG2084	Dehydrogenase
VAPA_RS26235	COG2271	Major facilitator Superfamily
VAPA_RS26240	COG2186	Transcriptional regulator
VAPA_RS26250	COG1522	sequence-specific DNA binding
VAPA_RS26275	COG4566	intracellular signal transduction
VAPA_RS26295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VAPA_RS26305	COG3550	peptidyl-serine autophosphorylation
VAPA_RS26310	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VAPA_RS26315	COG1595	DNA-templated transcription, initiation
VAPA_RS26330	COG0625	glutathione transferase activity
VAPA_RS26345	COG4772	TonB-dependent receptor
VAPA_RS26365	COG0861	Integral membrane protein TerC family
VAPA_RS26375	COG1950	PFAM Membrane protein of
VAPA_RS26380	COG4783	chaperone-mediated protein folding
VAPA_RS26385	COG0315	cyclic pyranopterin monophosphate synthase activity
VAPA_RS26435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAPA_RS26440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAPA_RS26470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VAPA_RS26480	COG4969	Belongs to the N-Me-Phe pilin family
VAPA_RS26495	COG1716	ATPase activity
VAPA_RS26505	COG0861	Integral membrane protein TerC family
VAPA_RS26510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VAPA_RS26515	COG0045	succinate-CoA ligase (ADP-forming) activity
VAPA_RS26520	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VAPA_RS26525	COG2137	regulation of response to DNA damage stimulus
VAPA_RS26530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VAPA_RS26545	COG0642	Histidine kinase
VAPA_RS26555	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VAPA_RS26555	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VAPA_RS26570	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS26575	COG0583	DNA-binding transcription factor activity
VAPA_RS26580	COG3181	Tripartite tricarboxylate transporter family receptor
VAPA_RS26595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VAPA_RS26610	COG2814	Major facilitator Superfamily
VAPA_RS26620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VAPA_RS26625	COG0513	Belongs to the DEAD box helicase family
VAPA_RS26640	COG1802	Transcriptional regulator
VAPA_RS26670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPA_RS26680	COG1473	amidohydrolase
VAPA_RS26700	COG1802	Transcriptional regulator
VAPA_RS26715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAPA_RS26720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPA_RS26725	COG4172	Belongs to the ABC transporter superfamily
VAPA_RS26730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_RS26740	COG0747	negative chemotaxis
VAPA_RS26750	COG1741	Belongs to the pirin family
VAPA_RS26765	COG2186	Transcriptional regulator
VAPA_RS26775	COG0765	amino acid transport
VAPA_RS26795	COG1047	Peptidyl-prolyl cis-trans
VAPA_RS26805	COG0154	amidase activity
VAPA_RS26835	COG1914	H( )-stimulated, divalent metal cation uptake system
VAPA_RS26840	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VAPA_RS26855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAPA_RS26860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAPA_RS26865	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VAPA_RS26870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VAPA_RS26875	COG0006	proline dipeptidase activity
VAPA_RS26880	COG0583	DNA-binding transcription factor activity
VAPA_RS26895	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VAPA_RS26915	COG0281	malic enzyme
VAPA_RS26915	COG0280	phosphate acetyltransferase
VAPA_RS26930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VAPA_RS26935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAPA_RS26940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VAPA_RS26950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VAPA_RS26965	COG2814	Major facilitator Superfamily
VAPA_RS26970	COG2267	carboxylic ester hydrolase activity
VAPA_RS26990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPA_RS26995	COG1739	Uncharacterized protein family UPF0029
VAPA_RS27000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAPA_RS27005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VAPA_RS27010	COG2119	membrane
VAPA_RS27015	COG0724	RNA recognition motif
VAPA_RS27020	COG0300	oxidoreductase activity
VAPA_RS27030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VAPA_RS27050	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VAPA_RS27050	COG2066	Belongs to the glutaminase family
VAPA_RS27055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VAPA_RS27060	COG0706	membrane insertase activity
VAPA_RS27065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VAPA_RS27070	COG0594	ribonuclease P activity
VAPA_RS27075	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VAPA_RS27230	COG2217	Heavy metal translocating P-type atpase
VAPA_RS27325	COG2096	Adenosyltransferase
VAPA_RS27340	COG0583	DNA-binding transcription factor activity
VAPA_RS27365	COG0850	regulation of cytokinetic process
VAPA_RS27505	COG1129	ABC transporter
VAPA_RS27725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPA_RS27920	COG2715	membrane protein required for spore maturation
VAPA_RS28075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VAPA_RS28080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VAPA_RS28540	COG0277	FAD linked oxidase domain protein
VAPA_RS28550	COG0247	lactate metabolic process
VAPA_RS28880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPA_RS28930	COG0768	penicillin binding
VAPA_RS29115	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS29130	COG1960	acyl-CoA dehydrogenase activity
VAPA_RS29140	COG0439	Biotin carboxylase
VAPA_RS29145	COG0439	Biotin carboxylase
VAPA_RS29235	COG1070	Carbohydrate kinase
VAPA_RS29495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAPA_RS29570	COG0318	PFAM AMP-dependent synthetase and ligase
VAPA_RS29585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPA_RS29770	COG0189	ligase activity
VAPA_RS29775	COG0189	ligase activity
VAPA_RS30530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPA_RS30915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VAPA_RS31565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAPA_RS32160	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAPA_RS32405	COG2943	transferase activity, transferring hexosyl groups
VAPA_RS32815	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPA_RS32920	COG2814	Major facilitator Superfamily
VAPA_RS33250	COG4772	TonB-dependent receptor
VAPA_RS33285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAPA_RS33540	COG0582	viral genome integration into host DNA
VAPA_RS33625	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates