locus-tag	class	description
VARPA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VARPA_RS00010	COG0592	DNA-directed DNA polymerase activity
VARPA_RS00040	COG1408	metallophosphoesterase
VARPA_RS00055	COG0392	lysyltransferase activity
VARPA_RS00060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS00065	COG3568	Endonuclease Exonuclease Phosphatase
VARPA_RS00095	COG0456	acetyltransferase
VARPA_RS00095	COG0454	-acetyltransferase
VARPA_RS00100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VARPA_RS00120	COG4452	Inner membrane protein CreD
VARPA_RS00140	COG2205	protein histidine kinase activity
VARPA_RS00145	COG0745	RESPONSE REGULATOR receiver
VARPA_RS00160	COG2608	mercury ion transmembrane transporter activity
VARPA_RS00165	COG2217	Heavy metal translocating P-type atpase
VARPA_RS00170	COG0456	acetyltransferase
VARPA_RS00185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VARPA_RS00195	COG0745	RESPONSE REGULATOR receiver
VARPA_RS00200	COG0642	Histidine kinase
VARPA_RS00205	COG0346	lactoylglutathione lyase activity
VARPA_RS00220	COG1902	pentaerythritol trinitrate reductase activity
VARPA_RS00230	COG1024	Enoyl-CoA hydratase
VARPA_RS00250	COG0445	tRNA wobble uridine modification
VARPA_RS00255	COG0357	Ribosomal RNA small subunit methyltransferase G
VARPA_RS00265	COG1192	Involved in chromosome partitioning
VARPA_RS00275	COG1475	DNA binding
VARPA_RS00285	COG0277	FAD linked oxidase domain protein
VARPA_RS00295	COG2096	Adenosyltransferase
VARPA_RS00330	COG0583	DNA-binding transcription factor activity
VARPA_RS00360	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VARPA_RS00365	COG2894	cell division
VARPA_RS00370	COG0850	regulation of cytokinetic process
VARPA_RS00375	COG2233	PERMEase
VARPA_RS00380	COG2050	protein possibly involved in aromatic compounds catabolism
VARPA_RS00390	COG1132	(ABC) transporter
VARPA_RS00410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VARPA_RS00430	COG1250	3-hydroxyacyl-CoA dehydrogenase
VARPA_RS00440	COG3246	L-lysine catabolic process to acetate
VARPA_RS00450	COG1942	4-Oxalocrotonate Tautomerase
VARPA_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS00490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VARPA_RS00510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VARPA_RS00555	COG3634	alkyl hydroperoxide reductase activity
VARPA_RS00570	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VARPA_RS00575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS00580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS00585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VARPA_RS00585	COG1116	anion transmembrane transporter activity
VARPA_RS00600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VARPA_RS00610	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VARPA_RS00630	COG2207	Transcriptional regulator
VARPA_RS00635	COG0583	DNA-binding transcription factor activity
VARPA_RS00640	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS00645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS00665	COG1276	copper resistance
VARPA_RS00675	COG1573	uracil-dna glycosylase
VARPA_RS00690	COG0583	DNA-binding transcription factor activity
VARPA_RS00695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VARPA_RS00715	COG2066	Belongs to the glutaminase family
VARPA_RS00740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VARPA_RS00745	COG0583	DNA-binding transcription factor activity
VARPA_RS00750	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VARPA_RS00755	COG0700	Nucleoside recognition
VARPA_RS00760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS00775	COG0410	ABC transporter
VARPA_RS00795	COG0683	leucine binding
VARPA_RS00800	COG0633	Ferredoxin
VARPA_RS00865	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
VARPA_RS00870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VARPA_RS00875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VARPA_RS00900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS00905	COG1116	anion transmembrane transporter activity
VARPA_RS00915	COG2986	histidine ammonia-lyase
VARPA_RS00920	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VARPA_RS00930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VARPA_RS00935	COG0765	amino acid transport
VARPA_RS00950	COG1228	amidohydrolase
VARPA_RS00955	COG0402	S-adenosylhomocysteine deaminase activity
VARPA_RS00980	COG0583	DNA-binding transcription factor activity
VARPA_RS00995	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VARPA_RS01000	COG1410	methionine synthase
VARPA_RS01000	COG0646	methionine synthase
VARPA_RS01025	COG1309	transcriptional regulator
VARPA_RS01055	COG0683	leucine binding
VARPA_RS01075	COG1335	isochorismatase
VARPA_RS01085	COG2080	2 iron, 2 sulfur cluster binding
VARPA_RS01090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VARPA_RS01090	COG2010	Cytochrome c
VARPA_RS01100	COG0606	chelatase, subunit chli
VARPA_RS01110	COG0347	Belongs to the P(II) protein family
VARPA_RS01120	COG0004	ammonium transporteR
VARPA_RS01130	COG0583	DNA-binding transcription factor activity
VARPA_RS01135	COG0277	FAD linked oxidase domain protein
VARPA_RS01140	COG0277	FAD linked oxidase domain protein
VARPA_RS01145	COG0247	lactate metabolic process
VARPA_RS01155	COG0386	Belongs to the glutathione peroxidase family
VARPA_RS01165	COG0477	Major facilitator Superfamily
VARPA_RS01170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VARPA_RS01190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VARPA_RS01215	COG3971	2-oxopent-4-enoate hydratase activity
VARPA_RS01240	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS01260	COG1846	Transcriptional regulator
VARPA_RS01290	COG1473	amidohydrolase
VARPA_RS01295	COG2974	May be involved in recombination
VARPA_RS01330	COG0745	RESPONSE REGULATOR receiver
VARPA_RS01335	COG0644	oxidoreductase
VARPA_RS01365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VARPA_RS01370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS01395	COG1079	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS01400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VARPA_RS01405	COG1335	isochorismatase
VARPA_RS01410	COG3845	ABC transporter
VARPA_RS01435	COG0583	DNA-binding transcription factor activity
VARPA_RS01440	COG0708	Exodeoxyribonuclease III
VARPA_RS01445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VARPA_RS01455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VARPA_RS01460	COG0154	amidase activity
VARPA_RS01465	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VARPA_RS01470	COG1077	Cell shape determining protein MreB Mrl
VARPA_RS01485	COG0768	penicillin binding
VARPA_RS01490	COG0179	Fumarylacetoacetate (FAA) hydrolase
VARPA_RS01500	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VARPA_RS01510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VARPA_RS01525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VARPA_RS01550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VARPA_RS01555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VARPA_RS01560	COG0583	DNA-binding transcription factor activity
VARPA_RS01600	COG1177	transmembrane transport
VARPA_RS01605	COG1176	ABC-type spermidine putrescine transport system, permease component I
VARPA_RS01610	COG3842	ATPase activity
VARPA_RS01635	COG0436	Aminotransferase
VARPA_RS01640	COG0028	Belongs to the TPP enzyme family
VARPA_RS01650	COG1473	amidohydrolase
VARPA_RS01655	COG0584	glycerophosphoryl diester phosphodiesterase
VARPA_RS01665	COG2733	membrane
VARPA_RS01680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VARPA_RS01695	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS01700	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS01710	COG0513	Belongs to the DEAD box helicase family
VARPA_RS01715	COG0023	Translation Initiation Factor
VARPA_RS01725	COG0724	RNA recognition motif
VARPA_RS01740	COG0004	ammonium transporteR
VARPA_RS01755	COG0243	molybdopterin cofactor binding
VARPA_RS01770	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS01775	COG1070	Carbohydrate kinase
VARPA_RS01780	COG1063	alcohol dehydrogenase
VARPA_RS01785	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS01795	COG1879	ABC-type sugar transport system periplasmic component
VARPA_RS01800	COG4977	sequence-specific DNA binding
VARPA_RS01805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS01840	COG0583	DNA-binding transcription factor activity
VARPA_RS01855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VARPA_RS01865	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS01870	COG0492	ferredoxin-NADP+ reductase activity
VARPA_RS01880	COG1946	Acyl-CoA thioesterase
VARPA_RS01895	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS01900	COG0659	secondary active sulfate transmembrane transporter activity
VARPA_RS01950	COG0667	Aldo Keto reductase
VARPA_RS01955	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS01960	COG1129	ABC transporter
VARPA_RS01975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VARPA_RS01980	COG2188	Transcriptional regulator
VARPA_RS01995	COG0629	single-stranded DNA binding
VARPA_RS02010	COG0217	transcriptional regulatory protein
VARPA_RS02015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VARPA_RS02020	COG1122	ATPase activity
VARPA_RS02030	COG1268	BioY protein
VARPA_RS02065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VARPA_RS02070	COG0482	sulfurtransferase activity
VARPA_RS02085	COG0745	RESPONSE REGULATOR receiver
VARPA_RS02105	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS02110	COG0601	transmembrane transport
VARPA_RS02115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VARPA_RS02120	COG0444	Belongs to the ABC transporter superfamily
VARPA_RS02125	COG4608	Belongs to the ABC transporter superfamily
VARPA_RS02130	COG0747	negative chemotaxis
VARPA_RS02135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VARPA_RS02145	COG0598	Magnesium transport protein CorA
VARPA_RS02155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VARPA_RS02165	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
VARPA_RS02170	COG0735	belongs to the Fur family
VARPA_RS02175	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VARPA_RS02180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VARPA_RS02195	COG0058	SHG alpha-glucan phosphorylase activity
VARPA_RS02200	COG0297	glycogen (starch) synthase activity
VARPA_RS02205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VARPA_RS02210	COG1523	belongs to the glycosyl hydrolase 13 family
VARPA_RS02220	COG0366	Alpha amylase catalytic
VARPA_RS02225	COG2072	flavoprotein involved in K transport
VARPA_RS02230	COG0495	leucyl-tRNA aminoacylation
VARPA_RS02245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VARPA_RS02255	COG3158	transport of potassium into the cell
VARPA_RS02270	COG0189	ligase activity
VARPA_RS02285	COG0121	glutamine amidotransferase
VARPA_RS02295	COG2814	Major facilitator Superfamily
VARPA_RS02310	COG0205	6-phosphofructokinase activity
VARPA_RS02315	COG1024	Enoyl-CoA hydratase
VARPA_RS02325	COG0583	DNA-binding transcription factor activity
VARPA_RS02330	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VARPA_RS02345	COG4804	nuclease activity
VARPA_RS02355	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VARPA_RS02360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VARPA_RS02370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VARPA_RS02375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS02395	COG0018	arginyl-trna synthetase
VARPA_RS02410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VARPA_RS02415	COG1137	ATPase activity
VARPA_RS02420	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VARPA_RS02425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS02445	COG3038	cytochrome b561
VARPA_RS02545	COG0069	glutamate synthase activity
VARPA_RS02550	COG3318	Belongs to the UPF0149 family
VARPA_RS02550	COG3012	SEC-C Motif Domain Protein
VARPA_RS02595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VARPA_RS02620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
VARPA_RS02635	COG2967	ApaG domain
VARPA_RS02640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VARPA_RS02680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS02700	COG3210	domain, Protein
VARPA_RS02715	COG1335	isochorismatase
VARPA_RS02725	COG5002	protein histidine kinase activity
VARPA_RS02735	COG2198	Histidine kinase
VARPA_RS02735	COG2205	protein histidine kinase activity
VARPA_RS02735	COG0784	Response regulator, receiver
VARPA_RS02740	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VARPA_RS02745	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VARPA_RS02770	COG0515	serine threonine protein kinase
VARPA_RS02945	COG2072	flavoprotein involved in K transport
VARPA_RS02955	COG2144	transferase activity, transferring acyl groups
VARPA_RS02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VARPA_RS02990	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS03005	COG1522	sequence-specific DNA binding
VARPA_RS03010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VARPA_RS03030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VARPA_RS03035	COG4166	transmembrane transport
VARPA_RS03040	COG0601	transmembrane transport
VARPA_RS03045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VARPA_RS03055	COG0473	3-isopropylmalate dehydrogenase activity
VARPA_RS03060	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS03075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VARPA_RS03080	COG1247	-acetyltransferase
VARPA_RS03085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VARPA_RS03105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VARPA_RS03110	COG1522	sequence-specific DNA binding
VARPA_RS03115	COG0546	phosphoglycolate phosphatase activity
VARPA_RS03145	COG1280	lysine exporter protein (LysE YggA)
VARPA_RS03150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VARPA_RS03155	COG0134	indole-3-glycerol-phosphate synthase activity
VARPA_RS03160	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VARPA_RS03180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VARPA_RS03200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VARPA_RS03205	COG0081	regulation of translation
VARPA_RS03210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VARPA_RS03215	COG0222	ribosome binding
VARPA_RS03220	COG0085	RNA polymerase activity
VARPA_RS03225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VARPA_RS03245	COG5000	phosphorelay sensor kinase activity
VARPA_RS03250	COG2204	response regulator
VARPA_RS03270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VARPA_RS03355	COG0582	viral genome integration into host DNA
VARPA_RS03425	COG0363	glucosamine-6-phosphate deaminase activity
VARPA_RS03445	COG1573	uracil-dna glycosylase
VARPA_RS03485	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VARPA_RS03490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VARPA_RS03495	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VARPA_RS03500	COG4770	biotin carboxylase activity
VARPA_RS03505	COG0596	Alpha beta hydrolase
VARPA_RS03520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VARPA_RS03535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VARPA_RS03540	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
VARPA_RS03550	COG0535	radical SAM domain protein
VARPA_RS03565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VARPA_RS03570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VARPA_RS03575	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VARPA_RS03580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VARPA_RS03590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VARPA_RS03600	COG1609	Transcriptional regulator
VARPA_RS03600	COG2207	Transcriptional regulator
VARPA_RS03625	COG1764	response to oxidative stress
VARPA_RS03640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VARPA_RS03650	COG1301	dicarboxylic acid transport
VARPA_RS03655	COG0183	Belongs to the thiolase family
VARPA_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS03675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VARPA_RS03690	COG0210	DNA helicase
VARPA_RS03695	COG0679	Auxin Efflux Carrier
VARPA_RS03715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VARPA_RS03720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VARPA_RS03730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VARPA_RS03735	COG4232	protein-disulfide reductase activity
VARPA_RS03765	COG0583	DNA-binding transcription factor activity
VARPA_RS03770	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS03780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VARPA_RS03795	COG0384	phenazine biosynthesis protein PhzF
VARPA_RS03800	COG0625	glutathione transferase activity
VARPA_RS03810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VARPA_RS03815	COG0697	spore germination
VARPA_RS03825	COG0436	Aminotransferase
VARPA_RS03840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VARPA_RS03860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VARPA_RS03875	COG0297	glycogen (starch) synthase activity
VARPA_RS03885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VARPA_RS03890	COG1215	transferase activity, transferring glycosyl groups
VARPA_RS03965	COG2755	lipolytic protein G-D-S-L family
VARPA_RS03965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VARPA_RS03980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VARPA_RS03985	COG1309	transcriptional regulator
VARPA_RS03990	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VARPA_RS04000	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS04005	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS04010	COG1129	ABC transporter
VARPA_RS04015	COG1879	ABC-type sugar transport system periplasmic component
VARPA_RS04020	COG2721	sulfolactate sulfo-lyase activity
VARPA_RS04025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VARPA_RS04035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VARPA_RS04040	COG2186	Transcriptional regulator
VARPA_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS04065	COG2188	Transcriptional regulator
VARPA_RS04070	COG0683	leucine binding
VARPA_RS04100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VARPA_RS04105	COG0066	3-isopropylmalate dehydratase activity
VARPA_RS04125	COG3573	Dehydrogenase
VARPA_RS04135	COG0583	DNA-binding transcription factor activity
VARPA_RS04140	COG4221	oxidoreductase activity
VARPA_RS04165	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS04175	COG1250	3-hydroxyacyl-CoA dehydrogenase
VARPA_RS04175	COG1024	Enoyl-CoA hydratase
VARPA_RS04180	COG2852	Protein conserved in bacteria
VARPA_RS04185	COG0183	Belongs to the thiolase family
VARPA_RS04210	COG1024	Enoyl-CoA hydratase
VARPA_RS04215	COG0683	leucine binding
VARPA_RS04220	COG1607	acyl-coa hydrolase
VARPA_RS04225	COG5265	(ABC) transporter
VARPA_RS04230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VARPA_RS04235	COG0154	amidase activity
VARPA_RS04240	COG0583	DNA-binding transcription factor activity
VARPA_RS04245	COG1027	Aspartate ammonia-lyase
VARPA_RS04250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VARPA_RS04255	COG0765	amino acid transport
VARPA_RS04260	COG0765	amino acid transport
VARPA_RS04265	COG1126	abc transporter atp-binding protein
VARPA_RS04275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VARPA_RS04280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VARPA_RS04280	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VARPA_RS04285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VARPA_RS04290	COG0583	DNA-binding transcription factor activity
VARPA_RS04295	COG0656	L-ascorbic acid biosynthetic process
VARPA_RS04325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VARPA_RS04355	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS04365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS04375	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS04380	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS04385	COG0183	Belongs to the thiolase family
VARPA_RS04395	COG0583	DNA-binding transcription factor activity
VARPA_RS04405	COG1881	PFAM PEBP family protein
VARPA_RS04420	COG1573	uracil-dna glycosylase
VARPA_RS04435	COG0154	amidase activity
VARPA_RS04440	COG0444	Belongs to the ABC transporter superfamily
VARPA_RS04445	COG4608	Belongs to the ABC transporter superfamily
VARPA_RS04450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VARPA_RS04455	COG0601	transmembrane transport
VARPA_RS04460	COG0747	negative chemotaxis
VARPA_RS04470	COG0418	dihydroorotase activity
VARPA_RS04490	COG0501	Belongs to the peptidase M48B family
VARPA_RS04500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VARPA_RS04510	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VARPA_RS04520	COG1275	C4-dicarboxylate transporter malic acid transport protein
VARPA_RS04535	COG1289	transmembrane transporter activity
VARPA_RS04545	COG1566	PFAM secretion protein HlyD family protein
VARPA_RS04555	COG2814	Major facilitator Superfamily
VARPA_RS04565	COG1187	pseudouridine synthase activity
VARPA_RS04575	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS04630	COG0583	DNA-binding transcription factor activity
VARPA_RS04645	COG1335	isochorismatase
VARPA_RS04665	COG2207	Transcriptional regulator
VARPA_RS04685	COG2207	Transcriptional regulator
VARPA_RS04700	COG2814	Major facilitator Superfamily
VARPA_RS04730	COG1595	DNA-templated transcription, initiation
VARPA_RS04750	COG0583	DNA-binding transcription factor activity
VARPA_RS04755	COG1335	isochorismatase
VARPA_RS04765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
VARPA_RS04770	COG2259	Doxx family
VARPA_RS04780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VARPA_RS04795	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VARPA_RS04805	COG0523	cobalamin synthesis protein
VARPA_RS04830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VARPA_RS04835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VARPA_RS04840	COG2001	Belongs to the MraZ family
VARPA_RS04845	COG0275	rRNA processing
VARPA_RS04860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VARPA_RS04865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VARPA_RS04870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VARPA_RS04875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VARPA_RS04880	COG0772	Belongs to the SEDS family
VARPA_RS04885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VARPA_RS04890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VARPA_RS04895	COG1181	Belongs to the D-alanine--D-alanine ligase family
VARPA_RS04900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VARPA_RS04915	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VARPA_RS04920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VARPA_RS04925	COG0575	Belongs to the CDS family
VARPA_RS04945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VARPA_RS04960	COG3150	esterase
VARPA_RS04965	COG2197	response regulator
VARPA_RS04970	COG4585	Histidine kinase
VARPA_RS04975	COG0772	Belongs to the SEDS family
VARPA_RS04980	COG0312	modulator of DNA gyrase
VARPA_RS04990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VARPA_RS05000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VARPA_RS05010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VARPA_RS05015	COG0511	ligase activity, forming carbon-carbon bonds
VARPA_RS05020	COG0439	Biotin carboxylase
VARPA_RS05025	COG2264	protein methyltransferase activity
VARPA_RS05035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VARPA_RS05050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VARPA_RS05050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VARPA_RS05075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VARPA_RS05080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VARPA_RS05090	COG2204	response regulator
VARPA_RS05100	COG2205	protein histidine kinase activity
VARPA_RS05105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VARPA_RS05120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VARPA_RS05155	COG0037	tRNA processing
VARPA_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS05180	COG2175	clavaminate synthase activity
VARPA_RS05190	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
VARPA_RS05195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS05230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VARPA_RS05240	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
VARPA_RS05245	COG3387	PFAM Glycoside hydrolase 15-related
VARPA_RS05250	COG1877	trehalose-phosphatase activity
VARPA_RS05260	COG0617	tRNA 3'-terminal CCA addition
VARPA_RS05270	COG0625	glutathione transferase activity
VARPA_RS05275	COG1285	pathogenesis
VARPA_RS05285	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VARPA_RS05290	COG0583	DNA-binding transcription factor activity
VARPA_RS05305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VARPA_RS05315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VARPA_RS05320	COG1522	sequence-specific DNA binding
VARPA_RS05330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VARPA_RS05355	COG3842	ATPase activity
VARPA_RS05370	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS05380	COG1129	ABC transporter
VARPA_RS05385	COG1879	ABC-type sugar transport system periplasmic component
VARPA_RS05390	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS05395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VARPA_RS05400	COG4154	Belongs to the RbsD FucU family
VARPA_RS05405	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS05410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VARPA_RS05415	COG1349	DNA-binding transcription factor activity
VARPA_RS05420	COG1522	sequence-specific DNA binding
VARPA_RS05435	COG1596	polysaccharide export
VARPA_RS05490	COG0506	proline dehydrogenase activity
VARPA_RS05490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VARPA_RS05490	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VARPA_RS05510	COG1902	pentaerythritol trinitrate reductase activity
VARPA_RS05515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VARPA_RS05530	COG3386	PFAM SMP-30 Gluconolaconase
VARPA_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS05545	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS05550	COG1879	ABC-type sugar transport system periplasmic component
VARPA_RS05555	COG4213	ABC transporter substrate-binding protein
VARPA_RS05565	COG4214	carbohydrate transport
VARPA_RS05570	COG1129	ABC transporter
VARPA_RS05575	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS05580	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS05595	COG0583	DNA-binding transcription factor activity
VARPA_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS05620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VARPA_RS05620	COG0189	ligase activity
VARPA_RS05625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VARPA_RS05625	COG0189	ligase activity
VARPA_RS05630	COG1132	(ABC) transporter
VARPA_RS05650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VARPA_RS05655	COG4178	(ABC) transporter
VARPA_RS05665	COG1840	ABC-type Fe3 transport system, periplasmic component
VARPA_RS05675	COG3842	ATPase activity
VARPA_RS05685	COG2271	Major facilitator Superfamily
VARPA_RS05690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VARPA_RS05700	COG2863	cytochrome
VARPA_RS05810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VARPA_RS05825	COG1765	OsmC-like protein
VARPA_RS05830	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
VARPA_RS05855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VARPA_RS05860	COG0444	Belongs to the ABC transporter superfamily
VARPA_RS05865	COG4608	Belongs to the ABC transporter superfamily
VARPA_RS05875	COG3384	dioxygenase
VARPA_RS05880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VARPA_RS05885	COG1840	ABC-type Fe3 transport system, periplasmic component
VARPA_RS05895	COG3842	ATPase activity
VARPA_RS05910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VARPA_RS05915	COG0166	Belongs to the GPI family
VARPA_RS05940	COG1175	transmembrane transport
VARPA_RS05945	COG0395	ABC-type sugar transport system, permease component
VARPA_RS05950	COG3842	ATPase activity
VARPA_RS05955	COG0246	Mannitol dehydrogenase
VARPA_RS05965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VARPA_RS05975	COG4753	response regulator
VARPA_RS05975	COG2207	Transcriptional regulator
VARPA_RS05980	COG1070	Carbohydrate kinase
VARPA_RS05985	COG0459	protein refolding
VARPA_RS05990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VARPA_RS06000	COG0583	DNA-binding transcription factor activity
VARPA_RS06020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS06025	COG4774	siderophore transport
VARPA_RS06040	COG4772	TonB-dependent receptor
VARPA_RS06045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VARPA_RS06055	COG1560	Kdo2-lipid A biosynthetic process
VARPA_RS06065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VARPA_RS06075	COG1333	cytochrome c biogenesis protein
VARPA_RS06080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VARPA_RS06085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VARPA_RS06090	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
VARPA_RS06095	COG0019	diaminopimelate decarboxylase activity
VARPA_RS06105	COG1965	Belongs to the frataxin family
VARPA_RS06140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VARPA_RS06145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VARPA_RS06150	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VARPA_RS06175	COG0067	glutamate synthase
VARPA_RS06175	COG0070	glutamate synthase
VARPA_RS06175	COG0069	glutamate synthase activity
VARPA_RS06185	COG1127	ABC transporter
VARPA_RS06190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VARPA_RS06195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VARPA_RS06200	COG2853	Lipoprotein
VARPA_RS06215	COG1131	(ABC) transporter
VARPA_RS06220	COG0842	Transport permease protein
VARPA_RS06225	COG5007	Belongs to the BolA IbaG family
VARPA_RS06230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VARPA_RS06235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VARPA_RS06260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VARPA_RS06265	COG0131	Imidazoleglycerol-phosphate dehydratase
VARPA_RS06275	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VARPA_RS06280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VARPA_RS06290	COG1301	dicarboxylic acid transport
VARPA_RS06300	COG0107	imidazoleglycerol-phosphate synthase activity
VARPA_RS06305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VARPA_RS06310	COG0140	phosphoribosyl-ATP diphosphatase activity
VARPA_RS06320	COG0537	adenosine 5'-monophosphoramidase activity
VARPA_RS06325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VARPA_RS06330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VARPA_RS06335	COG0805	protein transport
VARPA_RS06350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VARPA_RS06355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VARPA_RS06360	COG1970	mechanosensitive ion channel activity
VARPA_RS06365	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
VARPA_RS06375	COG2197	response regulator
VARPA_RS06380	COG0723	plastoquinol--plastocyanin reductase activity
VARPA_RS06385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VARPA_RS06390	COG2857	Cytochrome c1
VARPA_RS06395	COG0625	glutathione transferase activity
VARPA_RS06400	COG2969	positive regulation of protein catabolic process
VARPA_RS06410	COG4221	oxidoreductase activity
VARPA_RS06435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VARPA_RS06445	COG4591	ABC-type transport system involved in lipoprotein release permease component
VARPA_RS06450	COG1136	(ABC) transporter
VARPA_RS06455	COG1595	DNA-templated transcription, initiation
VARPA_RS06460	COG0740	serine-type endopeptidase activity
VARPA_RS06480	COG0601	transmembrane transport
VARPA_RS06510	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VARPA_RS06535	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VARPA_RS06545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VARPA_RS06570	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VARPA_RS06575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VARPA_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS06590	COG2030	dehydratase
VARPA_RS06590	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS06615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VARPA_RS06620	COG2151	metal-sulfur cluster biosynthetic enzyme
VARPA_RS06625	COG3396	Phenylacetate-CoA oxygenase
VARPA_RS06630	COG3460	Phenylacetate-CoA oxygenase
VARPA_RS06635	COG3396	Phenylacetate-CoA oxygenase
VARPA_RS06645	COG2050	protein possibly involved in aromatic compounds catabolism
VARPA_RS06650	COG1024	Enoyl-CoA hydratase
VARPA_RS06660	COG1309	transcriptional regulator
VARPA_RS06665	COG0300	oxidoreductase activity
VARPA_RS06675	COG2304	oxidoreductase activity
VARPA_RS06685	COG0714	Associated with various cellular activities
VARPA_RS06690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VARPA_RS06695	COG0084	hydrolase, TatD family'
VARPA_RS06710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VARPA_RS06715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VARPA_RS06730	COG0583	DNA-binding transcription factor activity
VARPA_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS06770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VARPA_RS06800	COG1283	sodium-dependent phosphate transmembrane transporter activity
VARPA_RS06805	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VARPA_RS06830	COG1609	Transcriptional regulator
VARPA_RS06835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VARPA_RS06845	COG0196	riboflavin kinase activity
VARPA_RS06860	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VARPA_RS06870	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS06875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VARPA_RS06895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VARPA_RS06895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VARPA_RS06905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VARPA_RS06910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VARPA_RS06915	COG0492	ferredoxin-NADP+ reductase activity
VARPA_RS06925	COG1674	ftsk spoiiie
VARPA_RS06930	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VARPA_RS06935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VARPA_RS06940	COG0559	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS06990	COG2816	NAD+ diphosphatase activity
VARPA_RS06995	COG0425	Belongs to the sulfur carrier protein TusA family
VARPA_RS07005	COG0525	valine-tRNA ligase activity
VARPA_RS07010	COG3022	response to hydroperoxide
VARPA_RS07020	COG2267	carboxylic ester hydrolase activity
VARPA_RS07025	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VARPA_RS07025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VARPA_RS07030	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS07045	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS07055	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS07065	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS07090	COG0540	Belongs to the ATCase OTCase family
VARPA_RS07100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VARPA_RS07105	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
VARPA_RS07115	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS07120	COG0583	DNA-binding transcription factor activity
VARPA_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS07175	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS07185	COG4948	Mandelate Racemase Muconate Lactonizing
VARPA_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS07205	COG0477	Major facilitator Superfamily
VARPA_RS07210	COG1304	FMN binding
VARPA_RS07215	COG0583	DNA-binding transcription factor activity
VARPA_RS07220	COG1620	l-lactate permease
VARPA_RS07235	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
VARPA_RS07240	COG4221	oxidoreductase activity
VARPA_RS07265	COG2832	Protein of unknown function (DUF454)
VARPA_RS07290	COG1120	ATPase activity
VARPA_RS07295	COG2807	transmembrane transport
VARPA_RS07300	COG2186	Transcriptional regulator
VARPA_RS07310	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
VARPA_RS07315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VARPA_RS07325	COG1280	lysine exporter protein (LysE YggA)
VARPA_RS07380	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS07405	COG0346	lactoylglutathione lyase activity
VARPA_RS07495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VARPA_RS07510	COG0165	Argininosuccinate lyase
VARPA_RS07515	COG3275	phosphorelay sensor kinase activity
VARPA_RS07550	COG0583	DNA-binding transcription factor activity
VARPA_RS07565	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VARPA_RS07570	COG0181	hydroxymethylbilane synthase activity
VARPA_RS07595	COG0583	DNA-binding transcription factor activity
VARPA_RS07600	COG1530	ribonuclease E activity
VARPA_RS07620	COG0616	signal peptide processing
VARPA_RS07620	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VARPA_RS07625	COG2223	nitrite transmembrane transporter activity
VARPA_RS07630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VARPA_RS07635	COG0424	maF-like protein
VARPA_RS07640	COG1399	metal-binding, possibly nucleic acid-binding protein
VARPA_RS07645	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VARPA_RS07650	COG0416	fatty acid biosynthetic process
VARPA_RS07655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VARPA_RS07665	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS07670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VARPA_RS07675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VARPA_RS07700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VARPA_RS07705	COG0481	GTPase activity
VARPA_RS07710	COG0681	Belongs to the peptidase S26 family
VARPA_RS07720	COG0571	ribonuclease III activity
VARPA_RS07725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VARPA_RS07730	COG1381	Involved in DNA repair and RecF pathway recombination
VARPA_RS07735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VARPA_RS07740	COG0736	holo-[acyl-carrier-protein] synthase activity
VARPA_RS07745	COG1472	Belongs to the glycosyl hydrolase 3 family
VARPA_RS07755	COG1451	nucleotide metabolic process
VARPA_RS07760	COG0443	Heat shock 70 kDa protein
VARPA_RS07780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VARPA_RS07790	COG0762	integral membrane protein
VARPA_RS07795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VARPA_RS07800	COG0159	tryptophan synthase activity
VARPA_RS07805	COG0133	tryptophan synthase activity
VARPA_RS07810	COG0135	phosphoribosylanthranilate isomerase activity
VARPA_RS07815	COG0101	tRNA pseudouridine synthase activity
VARPA_RS07825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VARPA_RS07830	COG0473	3-isopropylmalate dehydrogenase activity
VARPA_RS07835	COG0066	3-isopropylmalate dehydratase activity
VARPA_RS07840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VARPA_RS07850	COG0372	Belongs to the citrate synthase family
VARPA_RS07855	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VARPA_RS07860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VARPA_RS07865	COG1053	succinate dehydrogenase
VARPA_RS07880	COG2188	Transcriptional regulator
VARPA_RS07885	COG0039	L-malate dehydrogenase activity
VARPA_RS07890	COG4106	trans-aconitate 2-methyltransferase activity
VARPA_RS07965	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS07980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VARPA_RS08005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VARPA_RS08020	COG3483	tryptophan 2,3-dioxygenase activity
VARPA_RS08035	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VARPA_RS08045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VARPA_RS08050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VARPA_RS08060	COG0268	Binds directly to 16S ribosomal RNA
VARPA_RS08065	COG0728	peptidoglycan biosynthetic process
VARPA_RS08080	COG3795	YCII-related domain
VARPA_RS08085	COG3795	YCII-related domain
VARPA_RS08095	COG4941	Belongs to the sigma-70 factor family
VARPA_RS08100	COG4977	sequence-specific DNA binding
VARPA_RS08100	COG1917	Cupin 2, conserved barrel domain protein
VARPA_RS08120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VARPA_RS08125	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VARPA_RS08130	COG0617	tRNA 3'-terminal CCA addition
VARPA_RS08140	COG1392	Phosphate transport regulator
VARPA_RS08145	COG0306	phosphate transporter
VARPA_RS08160	COG0228	four-way junction DNA binding
VARPA_RS08165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VARPA_RS08170	COG0336	Belongs to the RNA methyltransferase TrmD family
VARPA_RS08175	COG0335	large ribosomal subunit rRNA binding
VARPA_RS08185	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VARPA_RS08190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VARPA_RS08195	COG1162	GTPase activity
VARPA_RS08200	COG2154	pterin-4-alpha-carbinolamine dehydratase
VARPA_RS08205	COG0501	Belongs to the peptidase M48B family
VARPA_RS08210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VARPA_RS08215	COG0513	Belongs to the DEAD box helicase family
VARPA_RS08220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VARPA_RS08225	COG1250	3-hydroxyacyl-CoA dehydrogenase
VARPA_RS08230	COG2267	carboxylic ester hydrolase activity
VARPA_RS08235	COG0604	alcohol dehydrogenase
VARPA_RS08235	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS08235	COG3321	synthase
VARPA_RS08260	COG4638	Rieske (2fe-2S)
VARPA_RS08275	COG0183	Belongs to the thiolase family
VARPA_RS08285	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VARPA_RS08295	COG0683	leucine binding
VARPA_RS08300	COG0683	leucine binding
VARPA_RS08305	COG4638	Rieske (2fe-2S)
VARPA_RS08310	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
VARPA_RS08335	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS08410	COG0516	GMP reductase activity
VARPA_RS08415	COG0210	DNA helicase
VARPA_RS08435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VARPA_RS08460	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VARPA_RS08470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VARPA_RS08485	COG4773	Receptor
VARPA_RS08510	COG0412	Dienelactone hydrolase
VARPA_RS08525	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VARPA_RS08530	COG4608	Belongs to the ABC transporter superfamily
VARPA_RS08535	COG0444	Belongs to the ABC transporter superfamily
VARPA_RS08540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VARPA_RS08545	COG0601	transmembrane transport
VARPA_RS08550	COG0747	negative chemotaxis
VARPA_RS08615	COG3064	Membrane
VARPA_RS08655	COG1722	exodeoxyribonuclease VII activity
VARPA_RS08660	COG0142	geranyltranstransferase activity
VARPA_RS08665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VARPA_RS08670	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VARPA_RS08685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VARPA_RS08690	COG0477	Major facilitator Superfamily
VARPA_RS08705	COG3842	ATPase activity
VARPA_RS08710	COG1840	ABC-type Fe3 transport system, periplasmic component
VARPA_RS08725	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS08735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VARPA_RS08755	COG2188	Transcriptional regulator
VARPA_RS08765	COG0559	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS08840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
VARPA_RS08840	COG3608	succinylglutamate desuccinylase aspartoacylase
VARPA_RS08845	COG1320	monovalent cation:proton antiporter activity
VARPA_RS08850	COG2212	antiporter activity
VARPA_RS08860	COG0651	ATP synthesis coupled electron transport
VARPA_RS08865	COG1006	Multisubunit Na H antiporter MnhC subunit
VARPA_RS08870	COG2111	Na H antiporter
VARPA_RS08870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VARPA_RS08875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VARPA_RS08890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VARPA_RS08900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VARPA_RS08920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VARPA_RS08925	COG0287	Prephenate dehydrogenase
VARPA_RS08930	COG1605	Chorismate mutase
VARPA_RS08930	COG0077	Prephenate dehydratase
VARPA_RS08935	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VARPA_RS08955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VARPA_RS08975	COG4797	methyltransferase
VARPA_RS08975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VARPA_RS09015	COG0174	glutamine synthetase
VARPA_RS09025	COG3852	Histidine kinase
VARPA_RS09040	COG0708	Exodeoxyribonuclease III
VARPA_RS09055	COG4948	Mandelate Racemase Muconate Lactonizing
VARPA_RS09060	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS09070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VARPA_RS09075	COG0583	DNA-binding transcription factor activity
VARPA_RS09085	COG0392	lysyltransferase activity
VARPA_RS09105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VARPA_RS09125	COG0277	FAD linked oxidase domain protein
VARPA_RS09135	COG1295	ribonuclease BN
VARPA_RS09145	COG3118	belongs to the thioredoxin family
VARPA_RS09155	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS09180	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VARPA_RS09185	COG0583	DNA-binding transcription factor activity
VARPA_RS09290	COG0477	Major facilitator Superfamily
VARPA_RS09295	COG4566	intracellular signal transduction
VARPA_RS09305	COG1538	Outer membrane efflux protein
VARPA_RS09320	COG1309	transcriptional regulator
VARPA_RS09335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VARPA_RS09350	COG0431	NADPH-dependent FMN reductase
VARPA_RS09360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VARPA_RS09365	COG0640	Transcriptional regulator
VARPA_RS09380	COG3070	regulator of competence-specific genes
VARPA_RS09385	COG0346	lactoylglutathione lyase activity
VARPA_RS09395	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VARPA_RS09400	COG0596	Alpha beta hydrolase
VARPA_RS09410	COG0625	glutathione transferase activity
VARPA_RS09425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VARPA_RS09430	COG2719	SpoVR family
VARPA_RS09435	COG2718	Belongs to the UPF0229 family
VARPA_RS09440	COG2766	serine protein kinase
VARPA_RS09445	COG0484	heat shock protein binding
VARPA_RS09450	COG0443	Heat shock 70 kDa protein
VARPA_RS09455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VARPA_RS09470	COG0688	phosphatidylethanolamine metabolic process
VARPA_RS09480	COG2706	6-phosphogluconolactonase activity
VARPA_RS09495	COG2721	sulfolactate sulfo-lyase activity
VARPA_RS09500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VARPA_RS09500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VARPA_RS09510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VARPA_RS09520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VARPA_RS09525	COG2186	Transcriptional regulator
VARPA_RS09530	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS09535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VARPA_RS09545	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS09560	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS09580	COG0842	Transport permease protein
VARPA_RS09585	COG0842	Transport permease protein
VARPA_RS09590	COG1131	(ABC) transporter
VARPA_RS09605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS09615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VARPA_RS09625	COG1802	Transcriptional regulator
VARPA_RS09660	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VARPA_RS09675	COG0583	DNA-binding transcription factor activity
VARPA_RS09680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VARPA_RS09685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS09705	COG2814	Major facilitator Superfamily
VARPA_RS09725	COG1295	ribonuclease BN
VARPA_RS09725	COG1959	2 iron, 2 sulfur cluster binding
VARPA_RS09740	COG0123	including yeast histone deacetylase and acetoin utilization protein
VARPA_RS09745	COG0824	Thioesterase
VARPA_RS09755	COG3237	CsbD-like
VARPA_RS09760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VARPA_RS09770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VARPA_RS09795	COG1309	transcriptional regulator
VARPA_RS09800	COG1611	Belongs to the LOG family
VARPA_RS09805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VARPA_RS09820	COG0405	Gamma-glutamyltransferase
VARPA_RS09825	COG0322	excinuclease ABC activity
VARPA_RS09840	COG0583	DNA-binding transcription factor activity
VARPA_RS09845	COG0596	Alpha beta hydrolase
VARPA_RS09850	COG0473	3-isopropylmalate dehydrogenase activity
VARPA_RS09865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VARPA_RS10065	COG2197	response regulator
VARPA_RS10070	COG0596	Alpha beta hydrolase
VARPA_RS10075	COG2205	protein histidine kinase activity
VARPA_RS10280	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VARPA_RS10285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VARPA_RS10300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VARPA_RS10310	COG3193	protein, possibly involved in utilization of glycolate and propanediol
VARPA_RS10335	COG3128	pkhd-type hydroxylase
VARPA_RS10340	COG4774	siderophore transport
VARPA_RS10345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VARPA_RS10350	COG1477	protein flavinylation
VARPA_RS10385	COG4771	TonB-dependent receptor
VARPA_RS10390	COG3720	iron ion transport
VARPA_RS10405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VARPA_RS10410	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VARPA_RS10415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VARPA_RS10430	COG0360	Binds together with S18 to 16S ribosomal RNA
VARPA_RS10435	COG2965	DNA replication, synthesis of RNA primer
VARPA_RS10440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VARPA_RS10445	COG0359	binds to the 23S rRNA
VARPA_RS10450	COG0305	Participates in initiation and elongation during chromosome replication
VARPA_RS10480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VARPA_RS10485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VARPA_RS10495	COG0436	Aminotransferase
VARPA_RS10510	COG1763	Mo-molybdopterin cofactor biosynthetic process
VARPA_RS10515	COG0303	'Molybdopterin
VARPA_RS10525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VARPA_RS10530	COG0314	molybdopterin synthase activity
VARPA_RS10540	COG0542	response to heat
VARPA_RS10550	COG1022	Amp-dependent synthetase and ligase
VARPA_RS10580	COG1309	transcriptional regulator
VARPA_RS10585	COG0183	Belongs to the thiolase family
VARPA_RS10620	COG3842	ATPase activity
VARPA_RS10625	COG2272	Belongs to the type-B carboxylesterase lipase family
VARPA_RS10630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS10635	COG1024	Enoyl-CoA hydratase
VARPA_RS10655	COG0583	DNA-binding transcription factor activity
VARPA_RS10680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VARPA_RS10685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VARPA_RS10715	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS10720	COG4974	Belongs to the 'phage' integrase family
VARPA_RS10725	COG0583	DNA-binding transcription factor activity
VARPA_RS10730	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VARPA_RS10735	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VARPA_RS10755	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS10770	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS10780	COG0183	Belongs to the thiolase family
VARPA_RS10795	COG2833	Protein of unknown function (DUF455)
VARPA_RS10805	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VARPA_RS10835	COG2831	hemolysin activation secretion protein
VARPA_RS10850	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS10870	COG3201	nicotinamide mononucleotide transporter
VARPA_RS10875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VARPA_RS10880	COG0148	phosphopyruvate hydratase activity
VARPA_RS10890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VARPA_RS10890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VARPA_RS10895	COG0504	CTP synthase activity
VARPA_RS10900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VARPA_RS10910	COG0756	dUTP diphosphatase activity
VARPA_RS10920	COG1047	Peptidyl-prolyl cis-trans
VARPA_RS10925	COG2850	peptidyl-arginine hydroxylation
VARPA_RS10940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VARPA_RS10945	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VARPA_RS10950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VARPA_RS10970	COG1196	nuclear chromosome segregation
VARPA_RS10970	COG0741	lytic transglycosylase activity
VARPA_RS10970	COG0739	heme binding
VARPA_RS11015	COG0765	amino acid transport
VARPA_RS11020	COG0765	amino acid transport
VARPA_RS11025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VARPA_RS11030	COG1126	abc transporter atp-binding protein
VARPA_RS11040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VARPA_RS11050	COG1609	Transcriptional regulator
VARPA_RS11070	COG0583	DNA-binding transcription factor activity
VARPA_RS11085	COG1305	Transglutaminase-like
VARPA_RS11110	COG1024	Enoyl-CoA hydratase
VARPA_RS11115	COG2308	Evidence 4 Homologs of previously reported genes of
VARPA_RS11135	COG2194	sulfuric ester hydrolase activity
VARPA_RS11145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VARPA_RS11160	COG3842	ATPase activity
VARPA_RS11165	COG3842	ATPase activity
VARPA_RS11175	COG0395	ABC-type sugar transport system, permease component
VARPA_RS11210	COG1131	(ABC) transporter
VARPA_RS11240	COG2951	lytic endotransglycosylase activity
VARPA_RS11255	COG0714	Associated with various cellular activities
VARPA_RS11265	COG3264	Mechanosensitive ion channel
VARPA_RS11265	COG1511	domain protein
VARPA_RS11280	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS11300	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS11310	COG2030	dehydratase
VARPA_RS11320	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS11325	COG1024	Enoyl-CoA hydratase
VARPA_RS11335	COG0640	Transcriptional regulator
VARPA_RS11350	COG3795	YCII-related domain
VARPA_RS11360	COG0477	Major facilitator Superfamily
VARPA_RS11370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VARPA_RS11415	COG3386	PFAM SMP-30 Gluconolaconase
VARPA_RS11420	COG1609	Transcriptional regulator
VARPA_RS11425	COG1063	alcohol dehydrogenase
VARPA_RS11430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VARPA_RS11435	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS11440	COG2084	Dehydrogenase
VARPA_RS11470	COG0642	Histidine kinase
VARPA_RS11475	COG0745	RESPONSE REGULATOR receiver
VARPA_RS11490	COG0745	RESPONSE REGULATOR receiver
VARPA_RS11500	COG1414	Transcriptional regulator
VARPA_RS11505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VARPA_RS11510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VARPA_RS11515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VARPA_RS11525	COG2814	Major facilitator Superfamily
VARPA_RS11535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
VARPA_RS11535	COG1082	Xylose isomerase domain protein TIM barrel
VARPA_RS11540	COG0477	Major facilitator Superfamily
VARPA_RS11560	COG0596	Alpha beta hydrolase
VARPA_RS11585	COG3148	PFAM DTW domain containing protein
VARPA_RS11640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VARPA_RS11655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VARPA_RS11685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VARPA_RS11685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VARPA_RS11690	COG0509	glycine decarboxylation via glycine cleavage system
VARPA_RS11695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VARPA_RS11725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VARPA_RS11735	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS11745	COG0824	Thioesterase
VARPA_RS11755	COG0642	Histidine kinase
VARPA_RS11760	COG0745	RESPONSE REGULATOR receiver
VARPA_RS11770	COG0671	phosphoesterase, PA-phosphatase related
VARPA_RS11830	COG4302	ethanolamine ammonia-lyase activity
VARPA_RS11835	COG4303	Ethanolamine ammonia lyase large subunit
VARPA_RS11840	COG0531	amino acid
VARPA_RS11845	COG0545	Peptidyl-prolyl cis-trans isomerase
VARPA_RS11850	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS11855	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VARPA_RS11925	COG2197	response regulator
VARPA_RS11975	COG1024	Enoyl-CoA hydratase
VARPA_RS11985	COG2223	nitrite transmembrane transporter activity
VARPA_RS11995	COG0583	DNA-binding transcription factor activity
VARPA_RS12000	COG0583	DNA-binding transcription factor activity
VARPA_RS12005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VARPA_RS12030	COG2818	Glycosylase
VARPA_RS12040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VARPA_RS12065	COG0625	glutathione transferase activity
VARPA_RS12070	COG1183	phosphatidylcholine synthase activity
VARPA_RS12075	COG0519	Catalyzes the synthesis of GMP from XMP
VARPA_RS12075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VARPA_RS12090	COG0640	Transcriptional regulator
VARPA_RS12100	COG1272	protein, Hemolysin III
VARPA_RS12105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VARPA_RS12120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VARPA_RS12125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VARPA_RS12135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VARPA_RS12145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VARPA_RS12165	COG1309	transcriptional regulator
VARPA_RS12175	COG1132	(ABC) transporter
VARPA_RS12185	COG3384	dioxygenase
VARPA_RS12195	COG3038	cytochrome b561
VARPA_RS12225	COG0587	DNA-directed DNA polymerase activity
VARPA_RS12255	COG0583	DNA-binding transcription factor activity
VARPA_RS12265	COG0583	DNA-binding transcription factor activity
VARPA_RS12270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS12280	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS12285	COG2272	Belongs to the type-B carboxylesterase lipase family
VARPA_RS12295	COG0674	pyruvate-flavodoxin oxidoreductase activity
VARPA_RS12295	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VARPA_RS12310	COG1309	transcriptional regulator
VARPA_RS12315	COG0604	alcohol dehydrogenase
VARPA_RS12350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VARPA_RS12355	COG2146	nitrite reductase [NAD(P)H] activity
VARPA_RS12360	COG2116	formate transmembrane transporter activity
VARPA_RS12365	COG0515	serine threonine protein kinase
VARPA_RS12365	COG2815	serine threonine protein kinase
VARPA_RS12410	COG2188	Transcriptional regulator
VARPA_RS12435	COG0625	glutathione transferase activity
VARPA_RS12445	COG3634	alkyl hydroperoxide reductase activity
VARPA_RS12465	COG0248	Ppx GppA phosphatase
VARPA_RS12470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VARPA_RS12475	COG0573	inorganic phosphate transmembrane transporter activity
VARPA_RS12480	COG0581	inorganic phosphate transmembrane transporter activity
VARPA_RS12485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VARPA_RS12500	COG5002	protein histidine kinase activity
VARPA_RS12505	COG0534	Mate efflux family protein
VARPA_RS12515	COG0254	rRNA binding
VARPA_RS12520	COG0673	inositol 2-dehydrogenase activity
VARPA_RS12525	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VARPA_RS12540	COG1074	ATP-dependent DNA helicase activity
VARPA_RS12550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VARPA_RS12555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VARPA_RS12560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VARPA_RS12570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VARPA_RS12580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS12585	COG0475	glutathione-regulated potassium exporter activity
VARPA_RS12585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VARPA_RS12590	COG1388	LysM domain
VARPA_RS12590	COG0741	lytic transglycosylase activity
VARPA_RS12595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VARPA_RS12600	COG2226	methyltransferase
VARPA_RS12605	COG0328	RNA-DNA hybrid ribonuclease activity
VARPA_RS12610	COG0303	'Molybdopterin
VARPA_RS12615	COG0746	molybdenum cofactor guanylyltransferase activity
VARPA_RS12620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VARPA_RS12645	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS12655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS12705	COG1522	sequence-specific DNA binding
VARPA_RS12725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VARPA_RS12755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VARPA_RS12780	COG0028	Belongs to the TPP enzyme family
VARPA_RS12785	COG0440	acetolactate synthase activity
VARPA_RS12795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VARPA_RS12800	COG1183	phosphatidylcholine synthase activity
VARPA_RS12805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VARPA_RS12810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VARPA_RS12820	COG1414	Transcriptional regulator
VARPA_RS12825	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VARPA_RS12830	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VARPA_RS12860	COG1414	Transcriptional regulator
VARPA_RS12870	COG0642	Histidine kinase
VARPA_RS12875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VARPA_RS12890	COG2197	response regulator
VARPA_RS12915	COG3384	dioxygenase
VARPA_RS12925	COG2159	amidohydrolase
VARPA_RS12930	COG0583	DNA-binding transcription factor activity
VARPA_RS12990	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS12995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VARPA_RS13045	COG2022	thiamine diphosphate biosynthetic process
VARPA_RS13060	COG0351	phosphomethylpyrimidine kinase
VARPA_RS13070	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VARPA_RS13085	COG0492	ferredoxin-NADP+ reductase activity
VARPA_RS13090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VARPA_RS13095	COG2895	sulfate adenylyltransferase (ATP) activity
VARPA_RS13135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VARPA_RS13140	COG0601	transmembrane transport
VARPA_RS13145	COG0747	negative chemotaxis
VARPA_RS13150	COG4172	Belongs to the ABC transporter superfamily
VARPA_RS13155	COG1446	asparaginase
VARPA_RS13165	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
VARPA_RS13190	COG0667	Aldo Keto reductase
VARPA_RS13195	COG0583	DNA-binding transcription factor activity
VARPA_RS13200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VARPA_RS13225	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS13230	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS13240	COG0523	cobalamin synthesis protein
VARPA_RS13250	COG2188	Transcriptional regulator
VARPA_RS13255	COG3588	fructose-bisphosphate aldolase
VARPA_RS13260	COG0427	acetyl-CoA hydrolase
VARPA_RS13265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VARPA_RS13270	COG1879	ABC-type sugar transport system periplasmic component
VARPA_RS13275	COG1129	ABC transporter
VARPA_RS13280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VARPA_RS13285	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS13305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VARPA_RS13315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VARPA_RS13320	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
VARPA_RS13325	COG0745	RESPONSE REGULATOR receiver
VARPA_RS13330	COG5002	protein histidine kinase activity
VARPA_RS13355	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VARPA_RS13355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VARPA_RS13360	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VARPA_RS13370	COG0431	NADPH-dependent FMN reductase
VARPA_RS13375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VARPA_RS13380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VARPA_RS13385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS13390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VARPA_RS13395	COG1116	anion transmembrane transporter activity
VARPA_RS13435	COG1045	serine acetyltransferase
VARPA_RS13445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VARPA_RS13450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VARPA_RS13460	COG3550	peptidyl-serine autophosphorylation
VARPA_RS13470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VARPA_RS13480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VARPA_RS13490	COG0450	alkyl hydroperoxide reductase
VARPA_RS13500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VARPA_RS13510	COG4208	sulfate ABC transporter
VARPA_RS13515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VARPA_RS13520	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VARPA_RS13525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VARPA_RS13535	COG1538	Outer membrane efflux protein
VARPA_RS13555	COG2226	methyltransferase
VARPA_RS13560	COG0217	transcriptional regulatory protein
VARPA_RS13565	COG0151	Belongs to the GarS family
VARPA_RS13570	COG0408	coproporphyrinogen oxidase activity
VARPA_RS13575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VARPA_RS13580	COG0799	negative regulation of ribosome biogenesis
VARPA_RS13585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VARPA_RS13590	COG0424	maF-like protein
VARPA_RS13595	COG1530	ribonuclease E activity
VARPA_RS13600	COG1132	(ABC) transporter
VARPA_RS13605	COG0823	Involved in the tonB-independent uptake of proteins
VARPA_RS13620	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VARPA_RS13630	COG0582	viral genome integration into host DNA
VARPA_RS13870	COG0514	ATP-dependent DNA helicase (RecQ)
VARPA_RS13945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
VARPA_RS13980	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
VARPA_RS13990	COG0667	Aldo Keto reductase
VARPA_RS14020	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VARPA_RS14040	COG0488	(ABC) transporter
VARPA_RS14045	COG2890	protein-(glutamine-N5) methyltransferase activity
VARPA_RS14050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VARPA_RS14060	COG2171	N-acyltransferase activity
VARPA_RS14075	COG1280	lysine exporter protein (LysE YggA)
VARPA_RS14080	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VARPA_RS14080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VARPA_RS14090	COG1643	Atp-dependent helicase
VARPA_RS14105	COG0436	Aminotransferase
VARPA_RS14110	COG0583	DNA-binding transcription factor activity
VARPA_RS14120	COG0795	lipopolysaccharide-transporting ATPase activity
VARPA_RS14130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VARPA_RS14190	COG1793	dna ligase
VARPA_RS14200	COG4166	transmembrane transport
VARPA_RS14205	COG4174	ABC transporter (Permease)
VARPA_RS14210	COG4239	(ABC) transporter, permease
VARPA_RS14215	COG4172	Belongs to the ABC transporter superfamily
VARPA_RS14220	COG0477	Major facilitator Superfamily
VARPA_RS14225	COG0779	Required for maturation of 30S ribosomal subunits
VARPA_RS14230	COG0195	Participates in both transcription termination and antitermination
VARPA_RS14230	COG2251	uridine kinase activity
VARPA_RS14235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VARPA_RS14240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VARPA_RS14245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VARPA_RS14250	COG1217	gtp-binding protein TYPA
VARPA_RS14285	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VARPA_RS14290	COG2867	negative regulation of translational initiation
VARPA_RS14320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VARPA_RS14320	COG0519	Catalyzes the synthesis of GMP from XMP
VARPA_RS14325	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VARPA_RS14340	COG2197	response regulator
VARPA_RS14345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VARPA_RS14350	COG0297	glycogen (starch) synthase activity
VARPA_RS14380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VARPA_RS14385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VARPA_RS14390	COG0489	protein tyrosine kinase activity
VARPA_RS14390	COG3206	protein involved in exopolysaccharide biosynthesis
VARPA_RS14395	COG1596	polysaccharide export
VARPA_RS14410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VARPA_RS14425	COG2204	response regulator
VARPA_RS14590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VARPA_RS14590	COG0515	serine threonine protein kinase
VARPA_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS14620	COG0583	DNA-binding transcription factor activity
VARPA_RS14655	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS14680	COG4566	intracellular signal transduction
VARPA_RS14710	COG1619	proteins homologs of microcin C7 resistance protein MccF
VARPA_RS14755	COG5002	protein histidine kinase activity
VARPA_RS14765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VARPA_RS14770	COG3850	Histidine kinase
VARPA_RS14770	COG2205	protein histidine kinase activity
VARPA_RS14770	COG3437	response regulator, receiver
VARPA_RS14770	COG4999	Histidine kinase
VARPA_RS14775	COG1199	ATP-dependent helicase activity
VARPA_RS14775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VARPA_RS14810	COG0156	8-amino-7-oxononanoate synthase activity
VARPA_RS14815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VARPA_RS14820	COG0667	Aldo Keto reductase
VARPA_RS14825	COG2207	Transcriptional regulator
VARPA_RS14830	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VARPA_RS14835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VARPA_RS14840	COG2814	Major facilitator Superfamily
VARPA_RS14855	COG0667	Aldo Keto reductase
VARPA_RS14860	COG3360	Dodecin
VARPA_RS14905	COG0045	succinate-CoA ligase (ADP-forming) activity
VARPA_RS14905	COG1042	CoA-binding domain protein
VARPA_RS14905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VARPA_RS14935	COG2197	response regulator
VARPA_RS14950	COG1793	dna ligase
VARPA_RS14980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VARPA_RS14985	COG0366	Alpha amylase catalytic
VARPA_RS14990	COG0366	Alpha amylase catalytic
VARPA_RS15005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VARPA_RS15010	COG1640	4-alpha-glucanotransferase
VARPA_RS15015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VARPA_RS15020	COG2010	Cytochrome c
VARPA_RS15020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VARPA_RS15040	COG2205	protein histidine kinase activity
VARPA_RS15070	COG2249	NAD(P)H dehydrogenase (quinone) activity
VARPA_RS15090	COG1063	alcohol dehydrogenase
VARPA_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS15135	COG1294	oxidase, subunit
VARPA_RS15140	COG1271	oxidase subunit
VARPA_RS15165	COG1132	(ABC) transporter
VARPA_RS15170	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
VARPA_RS15190	COG2155	Conserved Protein
VARPA_RS15215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VARPA_RS15235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VARPA_RS15245	COG0673	inositol 2-dehydrogenase activity
VARPA_RS15270	COG0500	methyltransferase
VARPA_RS15285	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VARPA_RS15295	COG2204	response regulator
VARPA_RS15305	COG2201	protein-glutamate methylesterase activity
VARPA_RS15315	COG3546	catalase activity
VARPA_RS15320	COG1058	Belongs to the CinA family
VARPA_RS15320	COG1546	Belongs to the CinA family
VARPA_RS15330	COG0492	ferredoxin-NADP+ reductase activity
VARPA_RS15380	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS15390	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS15425	COG3685	Protein conserved in bacteria
VARPA_RS15430	COG0596	Alpha beta hydrolase
VARPA_RS15460	COG0084	hydrolase, TatD family'
VARPA_RS15475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VARPA_RS15480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VARPA_RS15485	COG0354	folic acid binding
VARPA_RS15530	COG2183	response to ionizing radiation
VARPA_RS15535	COG4585	Histidine kinase
VARPA_RS15540	COG2201	protein-glutamate methylesterase activity
VARPA_RS15575	COG0534	Mate efflux family protein
VARPA_RS15585	COG4774	siderophore transport
VARPA_RS15590	COG3712	iron ion homeostasis
VARPA_RS15595	COG1595	DNA-templated transcription, initiation
VARPA_RS15600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VARPA_RS15605	COG1609	Transcriptional regulator
VARPA_RS15610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VARPA_RS15620	COG0477	Major facilitator Superfamily
VARPA_RS15630	COG3008	intermembrane lipid transfer
VARPA_RS15630	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VARPA_RS15635	COG2995	paraquat-inducible protein a
VARPA_RS15640	COG2995	paraquat-inducible protein a
VARPA_RS15645	COG2814	Major facilitator Superfamily
VARPA_RS15650	COG2814	Major facilitator Superfamily
VARPA_RS15675	COG1360	Flagellar Motor Protein
VARPA_RS15700	COG0583	DNA-binding transcription factor activity
VARPA_RS15710	COG0583	DNA-binding transcription factor activity
VARPA_RS15740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VARPA_RS15745	COG0477	Major facilitator Superfamily
VARPA_RS15750	COG0277	FAD linked oxidase domain protein
VARPA_RS15750	COG0247	lactate metabolic process
VARPA_RS15775	COG0583	DNA-binding transcription factor activity
VARPA_RS15780	COG2814	Major facilitator Superfamily
VARPA_RS15795	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VARPA_RS15830	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS15835	COG2130	NADP-dependent
VARPA_RS15860	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS15870	COG0183	Belongs to the thiolase family
VARPA_RS15875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VARPA_RS15880	COG1250	3-hydroxyacyl-CoA dehydrogenase
VARPA_RS15880	COG1024	Enoyl-CoA hydratase
VARPA_RS15890	COG0411	ABC transporter
VARPA_RS15915	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS15930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VARPA_RS15935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VARPA_RS15940	COG2917	probably involved in intracellular septation
VARPA_RS15950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VARPA_RS15955	COG0047	phosphoribosylformylglycinamidine synthase activity
VARPA_RS15955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VARPA_RS15960	COG0024	Methionine aminopeptidase
VARPA_RS15965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VARPA_RS15970	COG2199	diguanylate cyclase activity
VARPA_RS15970	COG2203	Gaf domain
VARPA_RS15985	COG2894	cell division
VARPA_RS15990	COG1215	transferase activity, transferring glycosyl groups
VARPA_RS15995	COG1215	transferase activity, transferring glycosyl groups
VARPA_RS16000	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
VARPA_RS16005	COG0457	Tetratricopeptide repeat
VARPA_RS16030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VARPA_RS16035	COG0765	amino acid transport
VARPA_RS16040	COG4597	amino acid ABC transporter
VARPA_RS16045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VARPA_RS16055	COG0242	peptide deformylase activity
VARPA_RS16065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VARPA_RS16075	COG1196	nuclear chromosome segregation
VARPA_RS16090	COG3550	peptidyl-serine autophosphorylation
VARPA_RS16135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VARPA_RS16150	COG0433	COG0433 Predicted ATPase
VARPA_RS16160	COG1595	DNA-templated transcription, initiation
VARPA_RS16185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VARPA_RS16190	COG1744	ABC transporter substrate-binding protein PnrA-like
VARPA_RS16195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VARPA_RS16205	COG3845	ABC transporter
VARPA_RS16210	COG4603	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS16215	COG1079	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS16230	COG0529	Catalyzes the synthesis of activated sulfate
VARPA_RS16235	COG0402	S-adenosylhomocysteine deaminase activity
VARPA_RS16255	COG2925	Exonuclease
VARPA_RS16260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS16265	COG0542	response to heat
VARPA_RS16270	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VARPA_RS16305	COG3047	cAMP biosynthetic process
VARPA_RS16305	COG2885	chlorophyll binding
VARPA_RS16360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VARPA_RS16365	COG1570	exodeoxyribonuclease VII activity
VARPA_RS16370	COG0811	peptide transport
VARPA_RS16375	COG0848	biopolymer transport protein
VARPA_RS16380	COG1663	tetraacyldisaccharide 4'-kinase activity
VARPA_RS16385	COG2835	tetraacyldisaccharide 4'-kinase activity
VARPA_RS16390	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VARPA_RS16395	COG0563	adenylate kinase activity
VARPA_RS16400	COG0252	asparaginase activity
VARPA_RS16405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VARPA_RS16415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VARPA_RS16420	COG2814	Major facilitator Superfamily
VARPA_RS16425	COG1250	3-hydroxyacyl-CoA dehydrogenase
VARPA_RS16430	COG1024	Enoyl-CoA hydratase
VARPA_RS16435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VARPA_RS16455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VARPA_RS16465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VARPA_RS16470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VARPA_RS16475	COG1534	Rna-binding protein
VARPA_RS16490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VARPA_RS16500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VARPA_RS16505	COG0505	Belongs to the CarA family
VARPA_RS16510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VARPA_RS16515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VARPA_RS16520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VARPA_RS16525	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VARPA_RS16530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VARPA_RS16535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VARPA_RS16545	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VARPA_RS16550	COG0750	zinc metalloprotease
VARPA_RS16555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VARPA_RS16560	COG0575	Belongs to the CDS family
VARPA_RS16570	COG0233	cytoplasmic translational termination
VARPA_RS16575	COG0528	UMP kinase activity
VARPA_RS16580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VARPA_RS16585	COG0052	Belongs to the universal ribosomal protein uS2 family
VARPA_RS16605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VARPA_RS16605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VARPA_RS16610	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS16615	COG0557	exoribonuclease II activity
VARPA_RS16630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VARPA_RS16635	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
VARPA_RS16650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VARPA_RS16660	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS16685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VARPA_RS16685	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VARPA_RS16690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VARPA_RS16690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VARPA_RS16695	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VARPA_RS16700	COG0560	Phosphoserine phosphatase
VARPA_RS16720	COG3712	iron ion homeostasis
VARPA_RS16730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VARPA_RS16735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VARPA_RS16750	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VARPA_RS16755	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VARPA_RS16760	COG1492	cobalamin metabolic process
VARPA_RS16770	COG1538	Outer membrane efflux protein
VARPA_RS16780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VARPA_RS16785	COG0657	acetylesterase activity
VARPA_RS16800	COG1346	cytolysis
VARPA_RS16805	COG1380	Effector of murein hydrolase LrgA
VARPA_RS16835	COG0778	Nitroreductase
VARPA_RS16840	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VARPA_RS16845	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VARPA_RS16850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VARPA_RS16865	COG1797	cobyrinic acid a,c-diamide synthase activity
VARPA_RS16885	COG0730	response to heat
VARPA_RS16900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VARPA_RS16920	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS16925	COG1024	Enoyl-CoA hydratase
VARPA_RS16940	COG1802	Transcriptional regulator
VARPA_RS16945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VARPA_RS16960	COG0583	DNA-binding transcription factor activity
VARPA_RS16965	COG0583	DNA-binding transcription factor activity
VARPA_RS16970	COG0129	dihydroxy-acid dehydratase activity
VARPA_RS16985	COG4654	Cytochrome c, class I
VARPA_RS16995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VARPA_RS17005	COG0583	DNA-binding transcription factor activity
VARPA_RS17010	COG2910	NAD(P)H-binding
VARPA_RS17015	COG0114	fumarate hydratase activity
VARPA_RS17025	COG4176	ABC-type proline glycine betaine transport system permease component
VARPA_RS17030	COG2113	Glycine betaine
VARPA_RS17040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VARPA_RS17080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VARPA_RS17085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VARPA_RS17090	COG0740	serine-type endopeptidase activity
VARPA_RS17095	COG0544	peptidyl-prolyl cis-trans isomerase activity
VARPA_RS17110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VARPA_RS17125	COG1562	ergosterol biosynthetic process
VARPA_RS17135	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
VARPA_RS17145	COG1280	lysine exporter protein (LysE YggA)
VARPA_RS17155	COG1011	Hydrolase
VARPA_RS17160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VARPA_RS17195	COG0411	ABC transporter
VARPA_RS17265	COG0642	Histidine kinase
VARPA_RS17270	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VARPA_RS17275	COG2326	polyphosphate kinase activity
VARPA_RS17290	COG4654	Cytochrome c, class I
VARPA_RS17320	COG0747	negative chemotaxis
VARPA_RS17325	COG0601	transmembrane transport
VARPA_RS17330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VARPA_RS17340	COG0154	amidase activity
VARPA_RS17350	COG3204	pilus organization
VARPA_RS17365	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS17380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VARPA_RS17385	COG0431	NADPH-dependent FMN reductase
VARPA_RS17415	COG1175	transmembrane transport
VARPA_RS17420	COG2182	Extracellular solute-binding protein
VARPA_RS17430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VARPA_RS17440	COG3829	transcription factor binding
VARPA_RS17470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VARPA_RS17490	COG0527	aspartate kinase activity
VARPA_RS17495	COG0037	tRNA processing
VARPA_RS17500	COG0825	malonyl-CoA metabolic process
VARPA_RS17510	COG0215	cysteine-tRNA ligase activity
VARPA_RS17525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VARPA_RS17530	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VARPA_RS17550	COG0741	lytic transglycosylase activity
VARPA_RS17555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VARPA_RS17560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VARPA_RS17595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VARPA_RS17595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VARPA_RS17610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VARPA_RS17615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VARPA_RS17620	COG0436	Aminotransferase
VARPA_RS17625	COG0824	Thioesterase
VARPA_RS17635	COG0848	biopolymer transport protein
VARPA_RS17655	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VARPA_RS17655	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VARPA_RS17670	COG1054	Belongs to the UPF0176 family
VARPA_RS17700	COG1741	Belongs to the pirin family
VARPA_RS17710	COG2259	Doxx family
VARPA_RS17715	COG1741	Belongs to the pirin family
VARPA_RS17730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VARPA_RS17735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VARPA_RS17750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VARPA_RS17800	COG3842	ATPase activity
VARPA_RS17820	COG2198	Histidine kinase
VARPA_RS17820	COG0784	Response regulator, receiver
VARPA_RS17820	COG2205	protein histidine kinase activity
VARPA_RS17825	COG3437	response regulator, receiver
VARPA_RS17840	COG0583	DNA-binding transcription factor activity
VARPA_RS17855	COG0784	Response regulator, receiver
VARPA_RS17860	COG4251	negative regulation of phosphorylation
VARPA_RS17880	COG0308	aminopeptidase N
VARPA_RS17885	COG2271	Major facilitator Superfamily
VARPA_RS17925	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS17930	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
VARPA_RS17935	COG0028	Belongs to the TPP enzyme family
VARPA_RS17940	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS17945	COG1414	Transcriptional regulator
VARPA_RS17965	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS17970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VARPA_RS17975	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VARPA_RS17980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VARPA_RS18000	COG3954	Phosphoribulokinase
VARPA_RS18005	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
VARPA_RS18010	COG0784	Response regulator, receiver
VARPA_RS18010	COG2205	protein histidine kinase activity
VARPA_RS18035	COG3383	formate dehydrogenase (NAD+) activity
VARPA_RS18070	COG0243	molybdopterin cofactor binding
VARPA_RS18070	COG3383	formate dehydrogenase (NAD+) activity
VARPA_RS18075	COG0437	4 iron, 4 sulfur cluster binding
VARPA_RS18095	COG0303	'Molybdopterin
VARPA_RS18100	COG0303	'Molybdopterin
VARPA_RS18115	COG0776	regulation of translation
VARPA_RS18170	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS18230	COG1024	Enoyl-CoA hydratase
VARPA_RS18250	COG1522	sequence-specific DNA binding
VARPA_RS18255	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS18290	COG1846	Transcriptional regulator
VARPA_RS18290	COG0456	acetyltransferase
VARPA_RS18295	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS18300	COG4689	acetoacetate decarboxylase
VARPA_RS18320	COG1295	ribonuclease BN
VARPA_RS18330	COG2059	Chromate
VARPA_RS18335	COG0667	Aldo Keto reductase
VARPA_RS18365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VARPA_RS18380	COG4181	ATPase activity
VARPA_RS18400	COG0626	cystathionine gamma-synthase activity
VARPA_RS18425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VARPA_RS18430	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
VARPA_RS18440	COG0330	HflC and HflK could
VARPA_RS18445	COG0330	HflC and HflK could
VARPA_RS18450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VARPA_RS18455	COG1923	regulation of RNA biosynthetic process
VARPA_RS18460	COG1160	GTP binding
VARPA_RS18475	COG0124	histidyl-tRNA synthetase
VARPA_RS18480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VARPA_RS18495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VARPA_RS18500	COG0105	UTP biosynthetic process
VARPA_RS18505	COG1187	pseudouridine synthase activity
VARPA_RS18510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VARPA_RS18515	COG0564	pseudouridine synthase activity
VARPA_RS18525	COG1199	ATP-dependent helicase activity
VARPA_RS18545	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VARPA_RS18550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VARPA_RS18555	COG0508	dehydrogenase complex catalyzes the overall conversion of
VARPA_RS18560	COG0567	Dehydrogenase, E1 component
VARPA_RS18590	COG2133	pyrroloquinoline quinone binding
VARPA_RS18595	COG0791	NLP P60 protein
VARPA_RS18600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VARPA_RS18605	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VARPA_RS18610	COG0508	dehydrogenase complex catalyzes the overall conversion of
VARPA_RS18615	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VARPA_RS18620	COG4191	Histidine kinase
VARPA_RS18625	COG4566	intracellular signal transduction
VARPA_RS18630	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VARPA_RS18645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VARPA_RS18650	COG0167	dihydroorotate dehydrogenase activity
VARPA_RS18665	COG0579	oxidoreductase
VARPA_RS18685	COG0633	Ferredoxin
VARPA_RS18690	COG0443	Heat shock 70 kDa protein
VARPA_RS18695	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VARPA_RS18705	COG0822	iron-sulfur transferase activity
VARPA_RS18710	COG1104	cysteine desulfurase activity
VARPA_RS18715	COG1959	2 iron, 2 sulfur cluster binding
VARPA_RS18720	COG0556	nucleotide-excision repair
VARPA_RS18735	COG2878	Part of a membrane complex involved in electron transport
VARPA_RS18745	COG0697	spore germination
VARPA_RS18750	COG1522	sequence-specific DNA binding
VARPA_RS18760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VARPA_RS18765	COG4770	biotin carboxylase activity
VARPA_RS18770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VARPA_RS18775	COG1703	isobutyryl-CoA mutase activity
VARPA_RS18785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VARPA_RS18785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VARPA_RS18790	COG1802	Transcriptional regulator
VARPA_RS18800	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VARPA_RS18805	COG2198	Histidine kinase
VARPA_RS18805	COG5002	protein histidine kinase activity
VARPA_RS18805	COG0784	Response regulator, receiver
VARPA_RS18825	COG1846	Transcriptional regulator
VARPA_RS18835	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS18840	COG1309	transcriptional regulator
VARPA_RS18850	COG0028	Belongs to the TPP enzyme family
VARPA_RS18900	COG2197	response regulator
VARPA_RS18930	COG0697	spore germination
VARPA_RS18945	COG2814	Major facilitator Superfamily
VARPA_RS19005	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS19010	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS19015	COG0179	Fumarylacetoacetate (FAA) hydrolase
VARPA_RS19025	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VARPA_RS19050	COG2249	NAD(P)H dehydrogenase (quinone) activity
VARPA_RS19060	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS19075	COG0583	DNA-binding transcription factor activity
VARPA_RS19085	COG1609	Transcriptional regulator
VARPA_RS19095	COG1879	ABC-type sugar transport system periplasmic component
VARPA_RS19100	COG1733	regulation of RNA biosynthetic process
VARPA_RS19165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VARPA_RS19215	COG4774	siderophore transport
VARPA_RS19230	COG4651	solute:proton antiporter activity
VARPA_RS19230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VARPA_RS19235	COG1301	dicarboxylic acid transport
VARPA_RS19240	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS19250	COG1058	Belongs to the CinA family
VARPA_RS19250	COG1546	Belongs to the CinA family
VARPA_RS19270	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
VARPA_RS19280	COG0583	DNA-binding transcription factor activity
VARPA_RS19285	COG0625	glutathione transferase activity
VARPA_RS19295	COG0183	Belongs to the thiolase family
VARPA_RS19300	COG3243	poly(R)-hydroxyalkanoic acid synthase
VARPA_RS19335	COG3045	CreA protein
VARPA_RS19345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS19365	COG1132	(ABC) transporter
VARPA_RS19370	COG1609	Transcriptional regulator
VARPA_RS19375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VARPA_RS19380	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VARPA_RS19390	COG1850	ribulose-bisphosphate carboxylase activity
VARPA_RS19435	COG3042	response to heat
VARPA_RS19470	COG1024	Enoyl-CoA hydratase
VARPA_RS19480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VARPA_RS19605	COG2831	hemolysin activation secretion protein
VARPA_RS19660	COG0776	regulation of translation
VARPA_RS19665	COG0072	phenylalanine-tRNA ligase activity
VARPA_RS19665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VARPA_RS19670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VARPA_RS19675	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VARPA_RS19680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VARPA_RS19685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VARPA_RS19690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VARPA_RS19725	COG0028	Belongs to the TPP enzyme family
VARPA_RS19730	COG1309	transcriptional regulator
VARPA_RS19740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS19745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VARPA_RS19760	COG0673	inositol 2-dehydrogenase activity
VARPA_RS19775	COG3214	Protein conserved in bacteria
VARPA_RS19780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VARPA_RS19805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VARPA_RS19810	COG0802	atpase or kinase
VARPA_RS19815	COG0860	N-Acetylmuramoyl-L-alanine amidase
VARPA_RS19825	COG0586	Pfam SNARE associated Golgi protein
VARPA_RS19835	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VARPA_RS19860	COG2207	Transcriptional regulator
VARPA_RS19865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VARPA_RS19870	COG4181	ATPase activity
VARPA_RS19880	COG2186	Transcriptional regulator
VARPA_RS19895	COG3795	YCII-related domain
VARPA_RS19900	COG4941	Belongs to the sigma-70 factor family
VARPA_RS19905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VARPA_RS19975	COG2814	Major facilitator Superfamily
VARPA_RS19980	COG1566	PFAM secretion protein HlyD family protein
VARPA_RS19985	COG1538	Outer membrane efflux protein
VARPA_RS19990	COG1846	Transcriptional regulator
VARPA_RS19995	COG1132	(ABC) transporter
VARPA_RS20005	COG0494	nUDIX hydrolase
VARPA_RS20015	COG1007	ATP synthesis coupled electron transport
VARPA_RS20030	COG0713	ATP synthesis coupled electron transport
VARPA_RS20040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VARPA_RS20045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VARPA_RS20050	COG1034	ATP synthesis coupled electron transport
VARPA_RS20065	COG0649	NAD binding
VARPA_RS20070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VARPA_RS20075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VARPA_RS20080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VARPA_RS20095	COG0149	triose-phosphate isomerase activity
VARPA_RS20105	COG1185	polyribonucleotide nucleotidyltransferase activity
VARPA_RS20110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VARPA_RS20115	COG0697	spore germination
VARPA_RS20120	COG0436	Aminotransferase
VARPA_RS20125	COG0683	leucine binding
VARPA_RS20135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VARPA_RS20140	COG3707	response regulator
VARPA_RS20145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VARPA_RS20150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS20155	COG1116	anion transmembrane transporter activity
VARPA_RS20165	COG2223	nitrite transmembrane transporter activity
VARPA_RS20170	COG0515	serine threonine protein kinase
VARPA_RS20170	COG2815	serine threonine protein kinase
VARPA_RS20175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VARPA_RS20185	COG0243	molybdopterin cofactor binding
VARPA_RS20195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VARPA_RS20210	COG3842	ATPase activity
VARPA_RS20220	COG1176	ABC-type spermidine putrescine transport system, permease component I
VARPA_RS20225	COG3833	ABC-type maltose transport systems, permease component
VARPA_RS20235	COG0791	NLP P60 protein
VARPA_RS20240	COG2081	HI0933 family
VARPA_RS20245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VARPA_RS20255	COG0494	nUDIX hydrolase
VARPA_RS20275	COG0385	Bile acid
VARPA_RS20280	COG2072	flavoprotein involved in K transport
VARPA_RS20285	COG0300	oxidoreductase activity
VARPA_RS20290	COG1063	alcohol dehydrogenase
VARPA_RS20295	COG3842	ATPase activity
VARPA_RS20300	COG0395	ABC-type sugar transport system, permease component
VARPA_RS20310	COG1653	transport
VARPA_RS20315	COG2814	Major facilitator Superfamily
VARPA_RS20325	COG0312	modulator of DNA gyrase
VARPA_RS20330	COG3028	Belongs to the UPF0307 family
VARPA_RS20335	COG0521	Mo-molybdopterin cofactor biosynthetic process
VARPA_RS20380	COG0475	glutathione-regulated potassium exporter activity
VARPA_RS20435	COG0789	Transcriptional regulator
VARPA_RS20460	COG1045	serine acetyltransferase
VARPA_RS20470	COG0483	inositol monophosphate 1-phosphatase activity
VARPA_RS20475	COG1289	transmembrane transporter activity
VARPA_RS20495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VARPA_RS20500	COG2207	Transcriptional regulator
VARPA_RS20515	COG2258	MOSC domain
VARPA_RS20545	COG3119	arylsulfatase activity
VARPA_RS20570	COG0747	negative chemotaxis
VARPA_RS20575	COG0601	transmembrane transport
VARPA_RS20580	COG4171	peptide transport system, permease
VARPA_RS20600	COG1695	Transcriptional regulator
VARPA_RS20605	COG2375	cellular response to nickel ion
VARPA_RS20610	COG0598	Magnesium transport protein CorA
VARPA_RS20620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VARPA_RS20640	COG4941	Belongs to the sigma-70 factor family
VARPA_RS20645	COG3795	YCII-related domain
VARPA_RS20650	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS20670	COG4585	Histidine kinase
VARPA_RS20675	COG1968	undecaprenyl-diphosphatase activity
VARPA_RS20710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VARPA_RS20735	COG3275	phosphorelay sensor kinase activity
VARPA_RS20750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VARPA_RS20785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VARPA_RS20790	COG0004	ammonium transporteR
VARPA_RS20815	COG4774	siderophore transport
VARPA_RS20830	COG1131	(ABC) transporter
VARPA_RS20835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VARPA_RS20850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VARPA_RS20870	COG0789	Transcriptional regulator
VARPA_RS20880	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS20885	COG2201	protein-glutamate methylesterase activity
VARPA_RS20890	COG2918	glutathione biosynthetic process
VARPA_RS20900	COG0400	carboxylic ester hydrolase activity
VARPA_RS20915	COG0523	cobalamin synthesis protein
VARPA_RS20920	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS20975	COG2354	Protein conserved in bacteria
VARPA_RS20990	COG4628	conserved protein (DUF2132)
VARPA_RS21005	COG0564	pseudouridine synthase activity
VARPA_RS21010	COG0589	response to stress
VARPA_RS21025	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
VARPA_RS21030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VARPA_RS21035	COG1252	NADH dehydrogenase
VARPA_RS21055	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS21060	COG1764	response to oxidative stress
VARPA_RS21080	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS21090	COG2271	Major facilitator Superfamily
VARPA_RS21105	COG0765	amino acid transport
VARPA_RS21110	COG0765	amino acid transport
VARPA_RS21135	COG0584	glycerophosphoryl diester phosphodiesterase
VARPA_RS21155	COG2132	Multicopper oxidase
VARPA_RS21180	COG3191	aminopeptidase activity
VARPA_RS21200	COG0789	Transcriptional regulator
VARPA_RS21210	COG0488	(ABC) transporter
VARPA_RS21215	COG0513	Belongs to the DEAD box helicase family
VARPA_RS21225	COG3842	ATPase activity
VARPA_RS21235	COG1175	transmembrane transport
VARPA_RS21245	COG2186	Transcriptional regulator
VARPA_RS21250	COG0129	dihydroxy-acid dehydratase activity
VARPA_RS21255	COG3734	2-keto-3-deoxy-galactonokinase
VARPA_RS21260	COG0800	Aldolase
VARPA_RS21295	COG2205	protein histidine kinase activity
VARPA_RS21300	COG0596	Alpha beta hydrolase
VARPA_RS21305	COG1840	ABC-type Fe3 transport system, periplasmic component
VARPA_RS21315	COG3842	ATPase activity
VARPA_RS21325	COG0346	lactoylglutathione lyase activity
VARPA_RS21340	COG0800	Aldolase
VARPA_RS21370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VARPA_RS21375	COG0259	pyridoxamine-phosphate oxidase activity
VARPA_RS21405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VARPA_RS21410	COG1309	transcriptional regulator
VARPA_RS21415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VARPA_RS21420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VARPA_RS21445	COG2169	Transcriptional regulator
VARPA_RS21455	COG0697	spore germination
VARPA_RS21470	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS21485	COG0277	FAD linked oxidase domain protein
VARPA_RS21500	COG0625	glutathione transferase activity
VARPA_RS21505	COG2366	antibiotic biosynthetic process
VARPA_RS21515	COG1538	Outer membrane efflux protein
VARPA_RS21520	COG0577	efflux transmembrane transporter activity
VARPA_RS21520	COG1136	(ABC) transporter
VARPA_RS21525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VARPA_RS21550	COG4774	siderophore transport
VARPA_RS21575	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
VARPA_RS21615	COG0583	DNA-binding transcription factor activity
VARPA_RS21620	COG2084	Dehydrogenase
VARPA_RS21630	COG0154	amidase activity
VARPA_RS21635	COG0747	negative chemotaxis
VARPA_RS21640	COG4608	Belongs to the ABC transporter superfamily
VARPA_RS21645	COG0444	Belongs to the ABC transporter superfamily
VARPA_RS21650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VARPA_RS21660	COG0473	3-isopropylmalate dehydrogenase activity
VARPA_RS21670	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS21675	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS21700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VARPA_RS21725	COG0285	dihydrofolate synthase activity
VARPA_RS21730	COG1393	Belongs to the ArsC family
VARPA_RS21740	COG3123	guanosine phosphorylase activity
VARPA_RS21745	COG0137	argininosuccinate synthase activity
VARPA_RS21755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VARPA_RS21760	COG1666	GTP binding
VARPA_RS21770	COG0251	oxidation-reduction process
VARPA_RS21775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VARPA_RS21780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VARPA_RS21785	COG0667	Aldo Keto reductase
VARPA_RS21790	COG2267	carboxylic ester hydrolase activity
VARPA_RS21820	COG2011	ABC-type metal ion transport system permease component
VARPA_RS21825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VARPA_RS21830	COG1464	Belongs to the NlpA lipoprotein family
VARPA_RS21835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VARPA_RS21840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VARPA_RS21845	COG0308	aminopeptidase N
VARPA_RS21850	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VARPA_RS21870	COG0477	Major facilitator Superfamily
VARPA_RS21965	COG3302	dmso reductase anchor subunit
VARPA_RS21970	COG0437	4 iron, 4 sulfur cluster binding
VARPA_RS21975	COG0243	molybdopterin cofactor binding
VARPA_RS21980	COG0583	DNA-binding transcription factor activity
VARPA_RS21985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VARPA_RS21995	COG1414	Transcriptional regulator
VARPA_RS22020	COG1012	belongs to the aldehyde dehydrogenase family
VARPA_RS22025	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS22070	COG1414	Transcriptional regulator
VARPA_RS22075	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
VARPA_RS22105	COG3046	protein related to deoxyribodipyrimidine photolyase
VARPA_RS22120	COG0583	DNA-binding transcription factor activity
VARPA_RS22125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS22130	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
VARPA_RS22135	COG4521	taurine ABC transporter
VARPA_RS22145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VARPA_RS22170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VARPA_RS22175	COG0444	Belongs to the ABC transporter superfamily
VARPA_RS22180	COG4608	Belongs to the ABC transporter superfamily
VARPA_RS22185	COG1228	amidohydrolase
VARPA_RS22245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS22280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VARPA_RS22285	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VARPA_RS22295	COG1253	flavin adenine dinucleotide binding
VARPA_RS22300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VARPA_RS22310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VARPA_RS22340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VARPA_RS22350	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS22355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VARPA_RS22370	COG0513	Belongs to the DEAD box helicase family
VARPA_RS22375	COG2321	neutral zinc metallopeptidase
VARPA_RS22380	COG0717	Belongs to the dCTP deaminase family
VARPA_RS22385	COG0402	S-adenosylhomocysteine deaminase activity
VARPA_RS22395	COG4221	oxidoreductase activity
VARPA_RS22410	COG2366	antibiotic biosynthetic process
VARPA_RS22415	COG4977	sequence-specific DNA binding
VARPA_RS22420	COG0583	DNA-binding transcription factor activity
VARPA_RS22425	COG2814	Major facilitator Superfamily
VARPA_RS22430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VARPA_RS22465	COG2301	Belongs to the HpcH HpaI aldolase family
VARPA_RS22470	COG0583	DNA-binding transcription factor activity
VARPA_RS22480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VARPA_RS22485	COG3287	FIST C domain
VARPA_RS22485	COG2199	diguanylate cyclase activity
VARPA_RS22485	COG2200	EAL domain
VARPA_RS22505	COG4603	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS22510	COG3845	ABC transporter
VARPA_RS22515	COG2252	PERMEase
VARPA_RS22525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VARPA_RS22555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VARPA_RS22605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VARPA_RS22650	COG2351	hydroxyisourate hydrolase activity
VARPA_RS22655	COG2186	Transcriptional regulator
VARPA_RS22670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VARPA_RS22700	COG3511	phospholipase C
VARPA_RS22755	COG1953	Uracil, thiamine, allantoin
VARPA_RS22770	COG2233	PERMEase
VARPA_RS22775	COG0656	L-ascorbic acid biosynthetic process
VARPA_RS22785	COG1301	dicarboxylic acid transport
VARPA_RS22795	COG0628	permease
VARPA_RS22810	COG0583	DNA-binding transcription factor activity
VARPA_RS22815	COG3960	tartronate-semialdehyde synthase activity
VARPA_RS22820	COG3622	Belongs to the hyi family
VARPA_RS22825	COG2084	Dehydrogenase
VARPA_RS22885	COG1116	anion transmembrane transporter activity
VARPA_RS22890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS22910	COG0745	RESPONSE REGULATOR receiver
VARPA_RS22930	COG1733	regulation of RNA biosynthetic process
VARPA_RS22945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VARPA_RS22955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VARPA_RS22965	COG0829	nickel cation binding
VARPA_RS23000	COG0583	DNA-binding transcription factor activity
VARPA_RS23020	COG0626	cystathionine gamma-synthase activity
VARPA_RS23035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VARPA_RS23050	COG2879	small protein
VARPA_RS23055	COG1966	Carbon starvation protein
VARPA_RS23060	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VARPA_RS23065	COG0791	NLP P60 protein
VARPA_RS23075	COG2207	Transcriptional regulator
VARPA_RS23100	COG0300	oxidoreductase activity
VARPA_RS23120	COG3386	PFAM SMP-30 Gluconolaconase
VARPA_RS23135	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VARPA_RS23155	COG2814	Major facilitator Superfamily
VARPA_RS23175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VARPA_RS23190	COG0667	Aldo Keto reductase
VARPA_RS23195	COG2814	Major facilitator Superfamily
VARPA_RS23215	COG0559	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS23230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VARPA_RS23235	COG0583	DNA-binding transcription factor activity
VARPA_RS23250	COG0306	phosphate transporter
VARPA_RS23260	COG0613	PHP domain protein
VARPA_RS23270	COG0009	L-threonylcarbamoyladenylate synthase
VARPA_RS23275	COG1994	Peptidase M50
VARPA_RS23280	COG0180	Tryptophanyl-tRNA synthetase
VARPA_RS23285	COG2197	response regulator
VARPA_RS23300	COG1950	PFAM Membrane protein of
VARPA_RS23315	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VARPA_RS23325	COG0489	protein tyrosine kinase activity
VARPA_RS23325	COG3206	protein involved in exopolysaccharide biosynthesis
VARPA_RS23330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VARPA_RS23345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VARPA_RS23370	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VARPA_RS23375	COG1596	polysaccharide export
VARPA_RS23390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VARPA_RS23395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VARPA_RS23400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VARPA_RS23405	COG1047	Peptidyl-prolyl cis-trans
VARPA_RS23410	COG2003	Belongs to the UPF0758 family
VARPA_RS23430	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VARPA_RS23440	COG0765	amino acid transport
VARPA_RS23445	COG0765	amino acid transport
VARPA_RS23460	COG2207	Transcriptional regulator
VARPA_RS23465	COG2080	2 iron, 2 sulfur cluster binding
VARPA_RS23470	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
VARPA_RS23475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VARPA_RS23480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VARPA_RS23485	COG0477	Major facilitator Superfamily
VARPA_RS23490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VARPA_RS23495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VARPA_RS23500	COG1845	cytochrome c oxidase, subunit III
VARPA_RS23505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VARPA_RS23520	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
VARPA_RS23525	COG1272	protein, Hemolysin III
VARPA_RS23530	COG2900	Belongs to the SlyX family
VARPA_RS23535	COG0477	Major facilitator Superfamily
VARPA_RS23540	COG0583	DNA-binding transcription factor activity
VARPA_RS23560	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VARPA_RS23570	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VARPA_RS23575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VARPA_RS23580	COG3639	organic phosphonate transmembrane transporter activity
VARPA_RS23585	COG3639	organic phosphonate transmembrane transporter activity
VARPA_RS23590	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
VARPA_RS23595	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VARPA_RS23605	COG0243	molybdopterin cofactor binding
VARPA_RS23620	COG0725	ABC transporter, periplasmic molybdate-binding protein
VARPA_RS23625	COG4149	molybdate abc transporter
VARPA_RS23640	COG2223	nitrite transmembrane transporter activity
VARPA_RS23645	COG0583	DNA-binding transcription factor activity
VARPA_RS23650	COG0489	protein tyrosine kinase activity
VARPA_RS23670	COG1473	amidohydrolase
VARPA_RS23675	COG1522	sequence-specific DNA binding
VARPA_RS23690	COG3132	Protein of unknown function, DUF480
VARPA_RS23695	COG3698	Phosphodiester glycosidase
VARPA_RS23700	COG0473	3-isopropylmalate dehydrogenase activity
VARPA_RS23705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VARPA_RS23705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VARPA_RS23715	COG0659	secondary active sulfate transmembrane transporter activity
VARPA_RS23735	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VARPA_RS23740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VARPA_RS23745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VARPA_RS23750	COG0602	queuosine metabolic process
VARPA_RS23760	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VARPA_RS23770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VARPA_RS23775	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VARPA_RS23785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VARPA_RS23790	COG0588	phosphoglycerate mutase activity
VARPA_RS23795	COG0793	Belongs to the peptidase S41A family
VARPA_RS23800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VARPA_RS23805	COG2982	Protein involved in outer membrane biogenesis
VARPA_RS23815	COG2197	response regulator
VARPA_RS23850	COG2823	Periplasmic or secreted lipoprotein
VARPA_RS23855	COG3237	CsbD-like
VARPA_RS23885	COG0494	nUDIX hydrolase
VARPA_RS23900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VARPA_RS23915	COG4145	pantothenate transmembrane transporter activity
VARPA_RS23920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VARPA_RS23935	COG2226	methyltransferase
VARPA_RS23960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VARPA_RS23970	COG1175	transmembrane transport
VARPA_RS23975	COG0395	ABC-type sugar transport system, permease component
VARPA_RS23980	COG3842	ATPase activity
VARPA_RS23985	COG0584	glycerophosphoryl diester phosphodiesterase
VARPA_RS23990	COG3264	Mechanosensitive ion channel
VARPA_RS23990	COG1511	domain protein
VARPA_RS23995	COG1522	sequence-specific DNA binding
VARPA_RS24005	COG4120	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS24010	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VARPA_RS24025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VARPA_RS24030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VARPA_RS24035	COG2890	protein-(glutamine-N5) methyltransferase activity
VARPA_RS24040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VARPA_RS24050	COG1253	flavin adenine dinucleotide binding
VARPA_RS24055	COG0741	lytic transglycosylase activity
VARPA_RS24060	COG0442	prolyl-tRNA aminoacylation
VARPA_RS24065	COG0494	nUDIX hydrolase
VARPA_RS24075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VARPA_RS24080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VARPA_RS24085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VARPA_RS24090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VARPA_RS24095	COG0142	geranyltranstransferase activity
VARPA_RS24115	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VARPA_RS24125	COG1696	Membrane protein involved in D-alanine export
VARPA_RS24135	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VARPA_RS24140	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VARPA_RS24145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VARPA_RS24145	COG2755	lipolytic protein G-D-S-L family
VARPA_RS24150	COG0494	nUDIX hydrolase
VARPA_RS24160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
VARPA_RS24165	COG0653	protein targeting
VARPA_RS24175	COG2423	ornithine cyclodeaminase activity
VARPA_RS24180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VARPA_RS24195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VARPA_RS24200	COG0583	DNA-binding transcription factor activity
VARPA_RS24215	COG0784	Response regulator, receiver
VARPA_RS24215	COG2205	protein histidine kinase activity
VARPA_RS24215	COG5002	protein histidine kinase activity
VARPA_RS24220	COG0831	urea catabolic process
VARPA_RS24230	COG0832	Belongs to the urease beta subunit family
VARPA_RS24235	COG0804	urea catabolic process
VARPA_RS24250	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
VARPA_RS24255	COG0830	nickel cation binding
VARPA_RS24260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VARPA_RS24290	COG0745	RESPONSE REGULATOR receiver
VARPA_RS24305	COG2205	protein histidine kinase activity
VARPA_RS24310	COG0745	RESPONSE REGULATOR receiver
VARPA_RS24315	COG1289	transmembrane transporter activity
VARPA_RS24330	COG1959	2 iron, 2 sulfur cluster binding
VARPA_RS24340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VARPA_RS24355	COG0473	3-isopropylmalate dehydrogenase activity
VARPA_RS24360	COG0066	3-isopropylmalate dehydratase activity
VARPA_RS24365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VARPA_RS24375	COG0583	DNA-binding transcription factor activity
VARPA_RS24390	COG0583	DNA-binding transcription factor activity
VARPA_RS24400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VARPA_RS24410	COG0024	Methionine aminopeptidase
VARPA_RS24440	COG1609	Transcriptional regulator
VARPA_RS24460	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS24470	COG0861	Integral membrane protein TerC family
VARPA_RS24535	COG1846	Transcriptional regulator
VARPA_RS24540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VARPA_RS24560	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS24635	COG4977	sequence-specific DNA binding
VARPA_RS24690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VARPA_RS24700	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS24705	COG0154	amidase activity
VARPA_RS24710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VARPA_RS24725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VARPA_RS24730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VARPA_RS24750	COG1561	YicC-like family, N-terminal region
VARPA_RS24755	COG0194	GDP metabolic process
VARPA_RS24760	COG1758	RNA polymerase activity
VARPA_RS24765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VARPA_RS24785	COG0861	Integral membrane protein TerC family
VARPA_RS24805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VARPA_RS24810	COG4792	protein secretion
VARPA_RS24815	COG1684	flagellar biosynthetic protein fliR
VARPA_RS24865	COG4789	Type iii secretion
VARPA_RS24875	COG4790	Type iii secretion
VARPA_RS24895	COG1420	regulation of RNA biosynthetic process
VARPA_RS24900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VARPA_RS24905	COG0497	DNA recombination
VARPA_RS24910	COG1660	Displays ATPase and GTPase activities
VARPA_RS24920	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
VARPA_RS24925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VARPA_RS24940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VARPA_RS24950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VARPA_RS24955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VARPA_RS24960	COG0193	aminoacyl-tRNA hydrolase activity
VARPA_RS24970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VARPA_RS24980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VARPA_RS24990	COG4608	Belongs to the ABC transporter superfamily
VARPA_RS24995	COG0747	negative chemotaxis
VARPA_RS25000	COG0747	negative chemotaxis
VARPA_RS25005	COG0154	amidase activity
VARPA_RS25015	COG0583	DNA-binding transcription factor activity
VARPA_RS25040	COG2267	carboxylic ester hydrolase activity
VARPA_RS25045	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VARPA_RS25050	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VARPA_RS25055	COG1984	allophanate hydrolase subunit 2
VARPA_RS25060	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VARPA_RS25065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VARPA_RS25070	COG0742	ribosomal rna small subunit methyltransferase
VARPA_RS25085	COG0612	Peptidase, M16
VARPA_RS25090	COG0612	Peptidase, M16
VARPA_RS25100	COG2205	protein histidine kinase activity
VARPA_RS25100	COG0784	Response regulator, receiver
VARPA_RS25115	COG0747	negative chemotaxis
VARPA_RS25125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VARPA_RS25145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VARPA_RS25165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VARPA_RS25170	COG4335	DNA alkylation repair
VARPA_RS25175	COG1999	signal sequence binding
VARPA_RS25180	COG0109	protoheme IX farnesyltransferase activity
VARPA_RS25215	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VARPA_RS25220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VARPA_RS25235	COG2226	methyltransferase
VARPA_RS25245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VARPA_RS25260	COG0489	protein tyrosine kinase activity
VARPA_RS25280	COG1024	Enoyl-CoA hydratase
VARPA_RS25300	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS25315	COG2764	glyoxalase bleomycin resistance protein dioxygenase
VARPA_RS25330	COG5507	3-demethylubiquinone-9 3-methyltransferase
VARPA_RS25340	COG3485	protocatechuate 3,4-dioxygenase
VARPA_RS25345	COG1252	NADH dehydrogenase
VARPA_RS25400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VARPA_RS25425	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VARPA_RS25440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VARPA_RS25460	COG0430	RNA-3'-phosphate cyclase activity
VARPA_RS25465	COG3541	Predicted nucleotidyltransferase
VARPA_RS25480	COG1690	Belongs to the RtcB family
VARPA_RS25490	COG4650	regulator
VARPA_RS25505	COG1073	alpha beta
VARPA_RS25530	COG0417	DNA replication proofreading
VARPA_RS25535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VARPA_RS25550	COG3468	outer membrane autotransporter barrel domain protein
VARPA_RS25570	COG5002	protein histidine kinase activity
VARPA_RS25570	COG2205	protein histidine kinase activity
VARPA_RS25570	COG0784	Response regulator, receiver
VARPA_RS25655	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS25660	COG0183	Belongs to the thiolase family
VARPA_RS25665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
VARPA_RS25675	COG1414	Transcriptional regulator
VARPA_RS25690	COG3063	Type IV pilus biogenesis stability protein PilW
VARPA_RS25705	COG4964	Belongs to the GSP D family
VARPA_RS25760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VARPA_RS25775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VARPA_RS25795	COG0583	DNA-binding transcription factor activity
VARPA_RS25800	COG3485	protocatechuate 3,4-dioxygenase
VARPA_RS25805	COG3485	protocatechuate 3,4-dioxygenase
VARPA_RS25815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VARPA_RS25840	COG2911	Protein conserved in bacteria
VARPA_RS25855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VARPA_RS25860	COG3383	formate dehydrogenase (NAD+) activity
VARPA_RS25875	COG0583	DNA-binding transcription factor activity
VARPA_RS25895	COG0469	pyruvate kinase activity
VARPA_RS25900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VARPA_RS25905	COG0179	Fumarylacetoacetate (FAA) hydrolase
VARPA_RS25910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VARPA_RS25915	COG0045	succinate-CoA ligase (ADP-forming) activity
VARPA_RS25920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VARPA_RS25925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS25930	COG4191	Histidine kinase
VARPA_RS26000	COG1733	regulation of RNA biosynthetic process
VARPA_RS26025	COG0540	Belongs to the ATCase OTCase family
VARPA_RS26030	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VARPA_RS26035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VARPA_RS26040	COG1678	Uncharacterized ACR, COG1678
VARPA_RS26045	COG0415	Belongs to the DNA photolyase family
VARPA_RS26050	COG2198	Histidine kinase
VARPA_RS26050	COG0784	Response regulator, receiver
VARPA_RS26050	COG0643	Histidine kinase
VARPA_RS26055	COG0840	transmembrane signaling receptor activity
VARPA_RS26080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VARPA_RS26090	COG0138	bifunctional purine biosynthesis protein purh
VARPA_RS26105	COG1238	metal cluster binding
VARPA_RS26115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VARPA_RS26130	COG0012	GTP binding
VARPA_RS26135	COG1879	ABC-type sugar transport system periplasmic component
VARPA_RS26140	COG1129	ABC transporter
VARPA_RS26145	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS26150	COG1609	Transcriptional regulator
VARPA_RS26155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VARPA_RS26160	COG1869	D-ribose catabolic process
VARPA_RS26170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VARPA_RS26190	COG1024	Enoyl-CoA hydratase
VARPA_RS26235	COG1999	signal sequence binding
VARPA_RS26245	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS26255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VARPA_RS26270	COG0183	Belongs to the thiolase family
VARPA_RS26280	COG2909	trisaccharide binding
VARPA_RS26295	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS26300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS26355	COG2255	four-way junction helicase activity
VARPA_RS26360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VARPA_RS26365	COG2267	carboxylic ester hydrolase activity
VARPA_RS26370	COG2453	phosphatase
VARPA_RS26370	COG0671	phosphoesterase, PA-phosphatase related
VARPA_RS26385	COG4589	Belongs to the CDS family
VARPA_RS26400	COG0632	four-way junction helicase activity
VARPA_RS26405	COG1702	phosphate starvation-inducible protein PhoH
VARPA_RS26410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VARPA_RS26415	COG1490	D-aminoacyl-tRNA deacylase activity
VARPA_RS26420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VARPA_RS26435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VARPA_RS26445	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VARPA_RS26450	COG2814	Major facilitator Superfamily
VARPA_RS26455	COG0316	Belongs to the HesB IscA family
VARPA_RS26460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VARPA_RS26465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VARPA_RS26475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VARPA_RS26480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VARPA_RS26490	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
VARPA_RS26495	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VARPA_RS26520	COG3243	poly(R)-hydroxyalkanoic acid synthase
VARPA_RS26530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VARPA_RS26545	COG4555	ABC transporter
VARPA_RS26565	COG3177	Filamentation induced by cAMP protein fic
VARPA_RS26580	COG2423	ornithine cyclodeaminase activity
VARPA_RS26585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VARPA_RS26600	COG0477	Major facilitator Superfamily
VARPA_RS26620	COG1280	lysine exporter protein (LysE YggA)
VARPA_RS26630	COG0583	DNA-binding transcription factor activity
VARPA_RS26635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS26640	COG3485	protocatechuate 3,4-dioxygenase
VARPA_RS26655	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS26660	COG1254	Belongs to the acylphosphatase family
VARPA_RS26670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS26685	COG1414	Transcriptional regulator
VARPA_RS26690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VARPA_RS26715	COG1024	Enoyl-CoA hydratase
VARPA_RS26720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VARPA_RS26725	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS26730	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS26750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VARPA_RS26755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VARPA_RS26760	COG3012	SEC-C Motif Domain Protein
VARPA_RS26765	COG0784	Response regulator, receiver
VARPA_RS26765	COG2205	protein histidine kinase activity
VARPA_RS26780	COG1408	metallophosphoesterase
VARPA_RS26785	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS26795	COG0183	Belongs to the thiolase family
VARPA_RS26800	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
VARPA_RS26805	COG0288	reversible hydration of carbon dioxide
VARPA_RS26810	COG0789	Transcriptional regulator
VARPA_RS26835	COG0129	dihydroxy-acid dehydratase activity
VARPA_RS26840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VARPA_RS26845	COG2186	Transcriptional regulator
VARPA_RS26850	COG3842	ATPase activity
VARPA_RS26865	COG3833	ABC-type maltose transport systems, permease component
VARPA_RS26880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VARPA_RS26895	COG0751	glycine-tRNA ligase activity
VARPA_RS26900	COG0752	glycyl-tRNA synthetase alpha subunit
VARPA_RS26905	COG1597	lipid kinase activity
VARPA_RS26935	COG2814	Major facilitator Superfamily
VARPA_RS26940	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VARPA_RS26945	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS26950	COG3246	L-lysine catabolic process to acetate
VARPA_RS26960	COG0411	ABC transporter
VARPA_RS26980	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS27015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS27025	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VARPA_RS27030	COG4535	Mg2 and Co2 transporter CorC
VARPA_RS27040	COG1522	sequence-specific DNA binding
VARPA_RS27055	COG3186	Phenylalanine-4-hydroxylase
VARPA_RS27060	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS27095	COG0488	(ABC) transporter
VARPA_RS27100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VARPA_RS27130	COG2095	MarC family integral membrane protein
VARPA_RS27150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VARPA_RS27160	COG0501	Belongs to the peptidase M48B family
VARPA_RS27200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VARPA_RS27230	COG0439	Biotin carboxylase
VARPA_RS27235	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS27255	COG2124	cytochrome p450
VARPA_RS27255	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VARPA_RS27265	COG1309	transcriptional regulator
VARPA_RS27285	COG1505	serine-type exopeptidase activity
VARPA_RS27290	COG0010	Belongs to the arginase family
VARPA_RS27300	COG1072	(Pantothenic acid kinase))
VARPA_RS27305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VARPA_RS27335	COG2084	Dehydrogenase
VARPA_RS27345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VARPA_RS27350	COG0792	nuclease activity
VARPA_RS27355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VARPA_RS27375	COG1309	transcriptional regulator
VARPA_RS27380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VARPA_RS27440	COG3118	belongs to the thioredoxin family
VARPA_RS27445	COG1201	RNA secondary structure unwinding
VARPA_RS27450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VARPA_RS27450	COG1793	dna ligase
VARPA_RS27455	COG1793	dna ligase
VARPA_RS27455	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VARPA_RS27475	COG1879	ABC-type sugar transport system periplasmic component
VARPA_RS27480	COG1172	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS27495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VARPA_RS27500	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VARPA_RS27510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VARPA_RS27515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VARPA_RS27520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VARPA_RS27525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VARPA_RS27535	COG0356	it plays a direct role in the translocation of protons across the membrane
VARPA_RS27545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VARPA_RS27550	COG2921	Belongs to the UPF0250 family
VARPA_RS27555	COG0321	lipoyl(octanoyl) transferase activity
VARPA_RS27560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VARPA_RS27735	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS27760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VARPA_RS27805	COG2130	NADP-dependent
VARPA_RS27815	COG0745	RESPONSE REGULATOR receiver
VARPA_RS27835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VARPA_RS27840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VARPA_RS27860	COG3909	cytochrome
VARPA_RS27875	COG0678	peroxiredoxin activity
VARPA_RS27880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VARPA_RS27885	COG0255	Belongs to the universal ribosomal protein uL29 family
VARPA_RS27890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VARPA_RS27895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VARPA_RS27900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VARPA_RS27905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VARPA_RS27910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VARPA_RS27915	COG0089	rRNA binding
VARPA_RS27920	COG0088	Forms part of the polypeptide exit tunnel
VARPA_RS27925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VARPA_RS27940	COG0051	transcription antitermination factor activity, RNA binding
VARPA_RS27945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VARPA_RS27950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VARPA_RS27955	COG0049	tRNA binding
VARPA_RS27960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VARPA_RS27965	COG1686	Belongs to the peptidase S11 family
VARPA_RS27970	COG2945	thiolester hydrolase activity
VARPA_RS27985	COG1981	membrane
VARPA_RS27995	COG0598	Magnesium transport protein CorA
VARPA_RS28010	COG0583	DNA-binding transcription factor activity
VARPA_RS28015	COG0412	Dienelactone hydrolase
VARPA_RS28025	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS28030	COG2095	MarC family integral membrane protein
VARPA_RS28065	COG0559	Belongs to the binding-protein-dependent transport system permease family
VARPA_RS28075	COG0657	acetylesterase activity
VARPA_RS28080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VARPA_RS28085	COG1250	3-hydroxyacyl-CoA dehydrogenase
VARPA_RS28100	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
VARPA_RS28105	COG1652	LysM domain
VARPA_RS28120	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VARPA_RS28135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VARPA_RS28135	COG0574	Belongs to the PEP-utilizing enzyme family
VARPA_RS28145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VARPA_RS28150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VARPA_RS28160	COG0640	Transcriptional regulator
VARPA_RS28165	COG2124	cytochrome p450
VARPA_RS28175	COG0625	glutathione transferase activity
VARPA_RS28180	COG0583	DNA-binding transcription factor activity
VARPA_RS28195	COG1131	(ABC) transporter
VARPA_RS28205	COG1846	Transcriptional regulator
VARPA_RS28210	COG1764	response to oxidative stress
VARPA_RS28220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VARPA_RS28225	COG0583	DNA-binding transcription factor activity
VARPA_RS28230	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS28235	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS28240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VARPA_RS28275	COG3552	Protein containing von Willebrand factor type A (VWA) domain
VARPA_RS28280	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VARPA_RS28285	COG0714	Associated with various cellular activities
VARPA_RS28305	COG0326	Molecular chaperone. Has ATPase activity
VARPA_RS28315	COG1840	ABC-type Fe3 transport system, periplasmic component
VARPA_RS28320	COG0583	DNA-binding transcription factor activity
VARPA_RS28330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VARPA_RS28340	COG0642	Histidine kinase
VARPA_RS28355	COG1187	pseudouridine synthase activity
VARPA_RS28360	COG1056	cytidyltransferase-related domain
VARPA_RS28360	COG1051	belongs to the nudix hydrolase family
VARPA_RS28370	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VARPA_RS28390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VARPA_RS28405	COG0745	RESPONSE REGULATOR receiver
VARPA_RS28410	COG2205	protein histidine kinase activity
VARPA_RS28420	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
VARPA_RS28425	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
VARPA_RS28430	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
VARPA_RS28445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VARPA_RS28460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VARPA_RS28475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VARPA_RS28485	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS28495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VARPA_RS28500	COG1022	Amp-dependent synthetase and ligase
VARPA_RS28530	COG0318	PFAM AMP-dependent synthetase and ligase
VARPA_RS28565	COG0372	Belongs to the citrate synthase family
VARPA_RS28570	COG0372	Belongs to the citrate synthase family
VARPA_RS28575	COG0693	protein deglycase activity
VARPA_RS28625	COG1940	carbohydrate kinase activity
VARPA_RS28630	COG1129	ABC transporter
VARPA_RS28635	COG4214	carbohydrate transport
VARPA_RS28640	COG4213	ABC transporter substrate-binding protein
VARPA_RS28650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VARPA_RS28655	COG0022	dehydrogenase e1 component
VARPA_RS28660	COG1028	Short-chain dehydrogenase reductase Sdr
VARPA_RS28665	COG0583	DNA-binding transcription factor activity
VARPA_RS28680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VARPA_RS28695	COG1024	Enoyl-CoA hydratase
VARPA_RS28700	COG1960	acyl-CoA dehydrogenase activity
VARPA_RS28715	COG4977	sequence-specific DNA binding
VARPA_RS28730	COG0203	ribosomal protein L17
VARPA_RS28735	COG0202	RNA polymerase activity
VARPA_RS28740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VARPA_RS28745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VARPA_RS28750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VARPA_RS28755	COG0201	protein transport
VARPA_RS28760	COG0200	Binds to the 23S rRNA
VARPA_RS28765	COG1841	ribosomal large subunit assembly
VARPA_RS28770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VARPA_RS28775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VARPA_RS28780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VARPA_RS28785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VARPA_RS28790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VARPA_RS28795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VARPA_RS28800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VARPA_RS28805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VARPA_RS28825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VARPA_RS28830	COG0783	Belongs to the Dps family
VARPA_RS28845	COG0038	chloride channel
VARPA_RS28865	COG1280	lysine exporter protein (LysE YggA)
VARPA_RS28870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VARPA_RS28875	COG1090	epimerase
VARPA_RS28885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VARPA_RS28890	COG0343	queuine tRNA-ribosyltransferase activity
VARPA_RS28945	COG0284	orotidine-5'-phosphate decarboxylase activity
VARPA_RS28960	COG1214	PFAM Peptidase M22, glycoprotease
VARPA_RS28965	COG1349	DNA-binding transcription factor activity
VARPA_RS28970	COG0494	nUDIX hydrolase
VARPA_RS28975	COG2027	D-alanyl-D-alanine carboxypeptidase
VARPA_RS28985	COG0009	L-threonylcarbamoyladenylate synthase
VARPA_RS28990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VARPA_RS28995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VARPA_RS29005	COG3620	sequence-specific DNA binding
VARPA_RS29010	COG3550	peptidyl-serine autophosphorylation
VARPA_RS29020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VARPA_RS29035	COG1522	sequence-specific DNA binding
VARPA_RS29040	COG2515	1-aminocyclopropane-1-carboxylate deaminase
VARPA_RS29045	COG0469	pyruvate kinase activity
VARPA_RS29050	COG0126	phosphoglycerate kinase activity
VARPA_RS29070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VARPA_RS29100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VARPA_RS29110	COG0242	peptide deformylase activity
VARPA_RS29120	COG0758	DNA mediated transformation
VARPA_RS29125	COG2922	Belongs to the Smg family
VARPA_RS29135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VARPA_RS29140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VARPA_RS29145	COG1862	Preprotein translocase
VARPA_RS29155	COG1522	sequence-specific DNA binding
VARPA_RS29180	COG0765	amino acid transport
VARPA_RS29185	COG2814	Major facilitator Superfamily
VARPA_RS29200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VARPA_RS29230	COG0251	oxidation-reduction process
VARPA_RS29240	COG3622	Belongs to the hyi family
VARPA_RS29245	COG0235	Class ii aldolase
VARPA_RS29250	COG3395	kinase activity
VARPA_RS29255	COG2084	Dehydrogenase
VARPA_RS29265	COG1522	sequence-specific DNA binding
VARPA_RS29295	COG4566	intracellular signal transduction
VARPA_RS29315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VARPA_RS29320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VARPA_RS29325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VARPA_RS29330	COG1595	DNA-templated transcription, initiation
VARPA_RS29355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VARPA_RS29370	COG0625	glutathione transferase activity
VARPA_RS29385	COG4772	TonB-dependent receptor
VARPA_RS29390	COG4681	YaeQ
VARPA_RS29405	COG0861	Integral membrane protein TerC family
VARPA_RS29415	COG1950	PFAM Membrane protein of
VARPA_RS29420	COG4783	chaperone-mediated protein folding
VARPA_RS29425	COG0315	cyclic pyranopterin monophosphate synthase activity
VARPA_RS29475	COG4969	Belongs to the N-Me-Phe pilin family
VARPA_RS29480	COG1234	tRNA 3'-trailer cleavage
VARPA_RS29490	COG1716	ATPase activity
VARPA_RS29495	COG0631	protein serine/threonine phosphatase activity
VARPA_RS29500	COG0861	Integral membrane protein TerC family
VARPA_RS29505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VARPA_RS29510	COG0045	succinate-CoA ligase (ADP-forming) activity
VARPA_RS29515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VARPA_RS29525	COG4682	membrane
VARPA_RS29535	COG2137	regulation of response to DNA damage stimulus
VARPA_RS29540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VARPA_RS29560	COG0642	Histidine kinase
VARPA_RS29575	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VARPA_RS29575	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VARPA_RS29595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VARPA_RS29615	COG2814	Major facilitator Superfamily
VARPA_RS29625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VARPA_RS29630	COG0513	Belongs to the DEAD box helicase family
VARPA_RS29645	COG0697	spore germination
VARPA_RS29655	COG1802	Transcriptional regulator
VARPA_RS29685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VARPA_RS29690	COG3550	peptidyl-serine autophosphorylation
VARPA_RS29705	COG1473	amidohydrolase
VARPA_RS29725	COG1047	Peptidyl-prolyl cis-trans
VARPA_RS29750	COG3181	Tripartite tricarboxylate transporter family receptor
VARPA_RS29760	COG0583	DNA-binding transcription factor activity
VARPA_RS29775	COG1914	H( )-stimulated, divalent metal cation uptake system
VARPA_RS29780	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VARPA_RS29795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VARPA_RS29800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VARPA_RS29805	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VARPA_RS29810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VARPA_RS29815	COG0006	proline dipeptidase activity
VARPA_RS29835	COG4953	penicillin-binding protein 1C
VARPA_RS29840	COG2373	Large extracellular alpha-helical protein
VARPA_RS29865	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VARPA_RS29885	COG0281	malic enzyme
VARPA_RS29885	COG0280	phosphate acetyltransferase
VARPA_RS29900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VARPA_RS29905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VARPA_RS29910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VARPA_RS29920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VARPA_RS29935	COG2814	Major facilitator Superfamily
VARPA_RS29940	COG2267	carboxylic ester hydrolase activity
VARPA_RS29960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VARPA_RS29965	COG1739	Uncharacterized protein family UPF0029
VARPA_RS29970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VARPA_RS29970	COG2813	Specifically methylates the guanine in position
VARPA_RS29975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VARPA_RS29980	COG2119	membrane
VARPA_RS29985	COG0724	RNA recognition motif
VARPA_RS29990	COG4221	oxidoreductase activity
VARPA_RS30000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VARPA_RS30020	COG2066	Belongs to the glutaminase family
VARPA_RS30020	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VARPA_RS30025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VARPA_RS30030	COG0706	membrane insertase activity
VARPA_RS30035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VARPA_RS30040	COG0594	ribonuclease P activity
VARPA_RS30045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VARPA_RS30075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VARPA_RS30090	COG1216	Glycosyl transferase, family 2
VARPA_RS30110	COG5002	protein histidine kinase activity
VARPA_RS30110	COG2205	protein histidine kinase activity
VARPA_RS30110	COG0784	Response regulator, receiver
VARPA_RS30115	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VARPA_RS30245	COG4608	Belongs to the ABC transporter superfamily
VARPA_RS30275	COG3210	domain, Protein
VARPA_RS30295	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine