locus-tag	class	description
VAPAR_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VAPAR_RS00015	COG0592	DNA-directed DNA polymerase activity
VAPAR_RS00045	COG1408	metallophosphoesterase
VAPAR_RS00055	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VAPAR_RS00060	COG0392	lysyltransferase activity
VAPAR_RS00065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPAR_RS00070	COG3568	Endonuclease Exonuclease Phosphatase
VAPAR_RS00100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAPAR_RS00120	COG4452	Inner membrane protein CreD
VAPAR_RS00135	COG2205	protein histidine kinase activity
VAPAR_RS00140	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS00155	COG2608	mercury ion transmembrane transporter activity
VAPAR_RS00160	COG2217	Heavy metal translocating P-type atpase
VAPAR_RS00165	COG0456	acetyltransferase
VAPAR_RS00170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAPAR_RS00185	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS00190	COG0642	Histidine kinase
VAPAR_RS00200	COG1902	pentaerythritol trinitrate reductase activity
VAPAR_RS00210	COG1024	Enoyl-CoA hydratase
VAPAR_RS00225	COG0445	tRNA wobble uridine modification
VAPAR_RS00230	COG0357	Ribosomal RNA small subunit methyltransferase G
VAPAR_RS00240	COG1192	Involved in chromosome partitioning
VAPAR_RS00260	COG0277	FAD linked oxidase domain protein
VAPAR_RS00270	COG2096	Adenosyltransferase
VAPAR_RS00305	COG0583	DNA-binding transcription factor activity
VAPAR_RS00320	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VAPAR_RS00325	COG2894	cell division
VAPAR_RS00330	COG0850	regulation of cytokinetic process
VAPAR_RS00335	COG2233	PERMEase
VAPAR_RS00340	COG2050	protein possibly involved in aromatic compounds catabolism
VAPAR_RS00355	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPAR_RS00365	COG3246	L-lysine catabolic process to acetate
VAPAR_RS00380	COG3284	Transcriptional regulator
VAPAR_RS00385	COG1942	4-Oxalocrotonate Tautomerase
VAPAR_RS00390	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS00455	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAPAR_RS00490	COG0492	ferredoxin-NADP+ reductase activity
VAPAR_RS00505	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VAPAR_RS00510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS00515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS00520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS00520	COG1116	anion transmembrane transporter activity
VAPAR_RS00535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAPAR_RS00540	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VAPAR_RS00550	COG3971	2-oxopent-4-enoate hydratase activity
VAPAR_RS00555	COG0154	amidase activity
VAPAR_RS00570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPAR_RS00580	COG1950	PFAM Membrane protein of
VAPAR_RS00585	COG0583	DNA-binding transcription factor activity
VAPAR_RS00590	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS00595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS00605	COG1276	copper resistance
VAPAR_RS00615	COG1573	uracil-dna glycosylase
VAPAR_RS00640	COG3246	L-lysine catabolic process to acetate
VAPAR_RS00645	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS00650	COG3485	protocatechuate 3,4-dioxygenase
VAPAR_RS00670	COG0583	DNA-binding transcription factor activity
VAPAR_RS00675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPAR_RS00685	COG2066	Belongs to the glutaminase family
VAPAR_RS00700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPAR_RS00705	COG0700	Nucleoside recognition
VAPAR_RS00710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPAR_RS00730	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
VAPAR_RS00735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAPAR_RS00755	COG0514	ATP-dependent DNA helicase (RecQ)
VAPAR_RS00765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS00780	COG2986	histidine ammonia-lyase
VAPAR_RS00785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VAPAR_RS00795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPAR_RS00800	COG0765	amino acid transport
VAPAR_RS00810	COG1228	amidohydrolase
VAPAR_RS00815	COG0402	S-adenosylhomocysteine deaminase activity
VAPAR_RS00845	COG1410	methionine synthase
VAPAR_RS00845	COG0646	methionine synthase
VAPAR_RS00870	COG1309	transcriptional regulator
VAPAR_RS00920	COG1335	isochorismatase
VAPAR_RS00930	COG2080	2 iron, 2 sulfur cluster binding
VAPAR_RS00935	COG2010	Cytochrome c
VAPAR_RS00935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPAR_RS01060	COG0515	serine threonine protein kinase
VAPAR_RS01060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPAR_RS01065	COG0606	chelatase, subunit chli
VAPAR_RS01075	COG0347	Belongs to the P(II) protein family
VAPAR_RS01080	COG0004	ammonium transporteR
VAPAR_RS01095	COG0277	FAD linked oxidase domain protein
VAPAR_RS01100	COG0277	FAD linked oxidase domain protein
VAPAR_RS01105	COG0247	lactate metabolic process
VAPAR_RS01115	COG0386	Belongs to the glutathione peroxidase family
VAPAR_RS01125	COG0477	Major facilitator Superfamily
VAPAR_RS01130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAPAR_RS01155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPAR_RS01170	COG0129	dihydroxy-acid dehydratase activity
VAPAR_RS01185	COG3971	2-oxopent-4-enoate hydratase activity
VAPAR_RS01195	COG3384	dioxygenase
VAPAR_RS01200	COG1012	belongs to the aldehyde dehydrogenase family
VAPAR_RS01215	COG1846	Transcriptional regulator
VAPAR_RS01225	COG3209	COG3209 Rhs family protein
VAPAR_RS01225	COG3209	COG3209 Rhs family protein
VAPAR_RS01250	COG2974	May be involved in recombination
VAPAR_RS01285	COG0579	oxidoreductase
VAPAR_RS01300	COG2211	Major facilitator Superfamily
VAPAR_RS01320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS01345	COG1079	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS01350	COG1335	isochorismatase
VAPAR_RS01355	COG3845	ABC transporter
VAPAR_RS01370	COG0708	Exodeoxyribonuclease III
VAPAR_RS01375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VAPAR_RS01385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VAPAR_RS01390	COG0154	amidase activity
VAPAR_RS01395	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VAPAR_RS01400	COG1077	Cell shape determining protein MreB Mrl
VAPAR_RS01415	COG0768	penicillin binding
VAPAR_RS01430	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VAPAR_RS01455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAPAR_RS01475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VAPAR_RS01480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAPAR_RS01485	COG0583	DNA-binding transcription factor activity
VAPAR_RS01500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPAR_RS01515	COG1177	transmembrane transport
VAPAR_RS01520	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPAR_RS01525	COG3842	ATPase activity
VAPAR_RS01545	COG0436	Aminotransferase
VAPAR_RS01550	COG0028	Belongs to the TPP enzyme family
VAPAR_RS01580	COG0724	RNA recognition motif
VAPAR_RS01590	COG0023	Translation Initiation Factor
VAPAR_RS01595	COG0513	Belongs to the DEAD box helicase family
VAPAR_RS01600	COG0330	HflC and HflK could
VAPAR_RS01605	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS01615	COG0439	Biotin carboxylase
VAPAR_RS01620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAPAR_RS01635	COG2733	membrane
VAPAR_RS01645	COG0584	glycerophosphoryl diester phosphodiesterase
VAPAR_RS01650	COG1473	amidohydrolase
VAPAR_RS01665	COG0243	molybdopterin cofactor binding
VAPAR_RS01680	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS01685	COG1070	Carbohydrate kinase
VAPAR_RS01690	COG1063	alcohol dehydrogenase
VAPAR_RS01695	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS01700	COG1129	ABC transporter
VAPAR_RS01705	COG1879	ABC-type sugar transport system periplasmic component
VAPAR_RS01710	COG2207	Transcriptional regulator
VAPAR_RS01715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS01760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPAR_RS01775	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAPAR_RS01780	COG1946	Acyl-CoA thioesterase
VAPAR_RS01785	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS01835	COG0667	Aldo Keto reductase
VAPAR_RS01840	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS01860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAPAR_RS01865	COG2188	Transcriptional regulator
VAPAR_RS01880	COG0629	single-stranded DNA binding
VAPAR_RS01895	COG0217	transcriptional regulatory protein
VAPAR_RS01910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPAR_RS01915	COG0482	sulfurtransferase activity
VAPAR_RS01950	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS01955	COG0601	transmembrane transport
VAPAR_RS01960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPAR_RS01965	COG0444	Belongs to the ABC transporter superfamily
VAPAR_RS01970	COG4608	Belongs to the ABC transporter superfamily
VAPAR_RS01975	COG0747	negative chemotaxis
VAPAR_RS01980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAPAR_RS01995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAPAR_RS02005	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
VAPAR_RS02010	COG0735	belongs to the Fur family
VAPAR_RS02015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPAR_RS02035	COG0058	SHG alpha-glucan phosphorylase activity
VAPAR_RS02040	COG0297	glycogen (starch) synthase activity
VAPAR_RS02045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAPAR_RS02050	COG1523	belongs to the glycosyl hydrolase 13 family
VAPAR_RS02055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAPAR_RS02060	COG0366	Alpha amylase catalytic
VAPAR_RS02065	COG2072	flavoprotein involved in K transport
VAPAR_RS02090	COG0495	leucyl-tRNA aminoacylation
VAPAR_RS02105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VAPAR_RS02115	COG3158	transport of potassium into the cell
VAPAR_RS02135	COG3135	benzoate transporter
VAPAR_RS02140	COG0189	ligase activity
VAPAR_RS02155	COG0121	glutamine amidotransferase
VAPAR_RS02165	COG2814	Major facilitator Superfamily
VAPAR_RS02180	COG0205	6-phosphofructokinase activity
VAPAR_RS02200	COG1024	Enoyl-CoA hydratase
VAPAR_RS02205	COG0183	Belongs to the thiolase family
VAPAR_RS02215	COG0583	DNA-binding transcription factor activity
VAPAR_RS02235	COG4804	nuclease activity
VAPAR_RS02240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VAPAR_RS02250	COG1414	Transcriptional regulator
VAPAR_RS02255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPAR_RS02260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS02285	COG0018	arginyl-trna synthetase
VAPAR_RS02300	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VAPAR_RS02305	COG1137	ATPase activity
VAPAR_RS02310	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VAPAR_RS02315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPAR_RS02370	COG0069	glutamate synthase activity
VAPAR_RS02375	COG0653	protein targeting
VAPAR_RS02400	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VAPAR_RS02420	COG1335	isochorismatase
VAPAR_RS02430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
VAPAR_RS02445	COG2967	ApaG domain
VAPAR_RS02450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VAPAR_RS02520	COG5002	protein histidine kinase activity
VAPAR_RS02530	COG2198	Histidine kinase
VAPAR_RS02530	COG0784	Response regulator, receiver
VAPAR_RS02530	COG2205	protein histidine kinase activity
VAPAR_RS02535	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VAPAR_RS02540	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
VAPAR_RS02565	COG0515	serine threonine protein kinase
VAPAR_RS02745	COG2072	flavoprotein involved in K transport
VAPAR_RS02755	COG2144	transferase activity, transferring acyl groups
VAPAR_RS02780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPAR_RS02820	COG0546	phosphoglycolate phosphatase activity
VAPAR_RS02840	COG0512	Glutamine amidotransferase of anthranilate synthase
VAPAR_RS02850	COG1280	lysine exporter protein (LysE YggA)
VAPAR_RS02855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAPAR_RS02860	COG0134	indole-3-glycerol-phosphate synthase activity
VAPAR_RS02865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VAPAR_RS02885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAPAR_RS02905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VAPAR_RS02910	COG0081	regulation of translation
VAPAR_RS02915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VAPAR_RS02920	COG0222	ribosome binding
VAPAR_RS02925	COG0085	RNA polymerase activity
VAPAR_RS02930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VAPAR_RS02950	COG5000	phosphorelay sensor kinase activity
VAPAR_RS02955	COG2204	response regulator
VAPAR_RS02965	COG2963	transposase activity
VAPAR_RS03075	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPAR_RS03085	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VAPAR_RS03095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS03100	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
VAPAR_RS03105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS03110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPAR_RS03115	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS03175	COG4638	Rieske (2fe-2S)
VAPAR_RS03180	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
VAPAR_RS03185	COG1335	isochorismatase
VAPAR_RS03230	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VAPAR_RS03255	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPAR_RS03290	COG0625	glutathione transferase activity
VAPAR_RS03295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAPAR_RS03295	COG1017	nitric oxide dioxygenase activity
VAPAR_RS03300	COG3436	PFAM IS66 Orf2 family protein
VAPAR_RS03305	COG4372	Transposase
VAPAR_RS03355	COG4372	Transposase
VAPAR_RS03360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPAR_RS03380	COG1484	DNA-dependent DNA replication
VAPAR_RS03395	COG0582	viral genome integration into host DNA
VAPAR_RS03400	COG0840	transmembrane signaling receptor activity
VAPAR_RS03420	COG0668	transmembrane transport
VAPAR_RS03445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPAR_RS03460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPAR_RS03475	COG0438	transferase activity, transferring glycosyl groups
VAPAR_RS03510	COG0154	amidase activity
VAPAR_RS03525	COG0776	regulation of translation
VAPAR_RS03530	COG0583	DNA-binding transcription factor activity
VAPAR_RS03545	COG5002	protein histidine kinase activity
VAPAR_RS03545	COG5001	Diguanylate cyclase
VAPAR_RS03545	COG3447	MASE1 domain protein
VAPAR_RS03550	COG2205	protein histidine kinase activity
VAPAR_RS03555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VAPAR_RS03570	COG0210	DNA helicase
VAPAR_RS03575	COG0679	Auxin Efflux Carrier
VAPAR_RS03595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VAPAR_RS03600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VAPAR_RS03610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAPAR_RS03640	COG0583	DNA-binding transcription factor activity
VAPAR_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS03655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAPAR_RS03670	COG0384	phenazine biosynthesis protein PhzF
VAPAR_RS03675	COG0625	glutathione transferase activity
VAPAR_RS03690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPAR_RS03695	COG0697	spore germination
VAPAR_RS03720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPAR_RS03750	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VAPAR_RS03755	COG0438	transferase activity, transferring glycosyl groups
VAPAR_RS03770	COG0438	transferase activity, transferring glycosyl groups
VAPAR_RS03795	COG0662	Cupin 2, conserved barrel domain protein
VAPAR_RS03795	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VAPAR_RS03800	COG0438	transferase activity, transferring glycosyl groups
VAPAR_RS03800	COG1216	Glycosyl transferase, family 2
VAPAR_RS03815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAPAR_RS03815	COG2755	lipolytic protein G-D-S-L family
VAPAR_RS03830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAPAR_RS03835	COG0438	transferase activity, transferring glycosyl groups
VAPAR_RS03835	COG1216	Glycosyl transferase, family 2
VAPAR_RS03840	COG0438	transferase activity, transferring glycosyl groups
VAPAR_RS03840	COG1216	Glycosyl transferase, family 2
VAPAR_RS03850	COG1309	transcriptional regulator
VAPAR_RS03855	COG0753	catalase activity
VAPAR_RS03875	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VAPAR_RS03880	COG2721	sulfolactate sulfo-lyase activity
VAPAR_RS03885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPAR_RS03895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPAR_RS03900	COG2186	Transcriptional regulator
VAPAR_RS03905	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS03915	COG0179	Fumarylacetoacetate (FAA) hydrolase
VAPAR_RS03955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAPAR_RS03960	COG0066	3-isopropylmalate dehydratase activity
VAPAR_RS04000	COG0583	DNA-binding transcription factor activity
VAPAR_RS04005	COG4221	oxidoreductase activity
VAPAR_RS04015	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS04025	COG1024	Enoyl-CoA hydratase
VAPAR_RS04025	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPAR_RS04030	COG2852	Protein conserved in bacteria
VAPAR_RS04035	COG0183	Belongs to the thiolase family
VAPAR_RS04060	COG1024	Enoyl-CoA hydratase
VAPAR_RS04065	COG0683	leucine binding
VAPAR_RS04075	COG5265	(ABC) transporter
VAPAR_RS04080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPAR_RS04085	COG0154	amidase activity
VAPAR_RS04090	COG0583	DNA-binding transcription factor activity
VAPAR_RS04095	COG1027	Aspartate ammonia-lyase
VAPAR_RS04100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPAR_RS04105	COG0765	amino acid transport
VAPAR_RS04110	COG0765	amino acid transport
VAPAR_RS04115	COG1126	abc transporter atp-binding protein
VAPAR_RS04125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPAR_RS04130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPAR_RS04130	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPAR_RS04135	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPAR_RS04140	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS04145	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS04150	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS04155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS04160	COG1024	Enoyl-CoA hydratase
VAPAR_RS04165	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS04170	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS04175	COG0183	Belongs to the thiolase family
VAPAR_RS04180	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPAR_RS04180	COG1024	Enoyl-CoA hydratase
VAPAR_RS04185	COG0583	DNA-binding transcription factor activity
VAPAR_RS04190	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
VAPAR_RS04200	COG0154	amidase activity
VAPAR_RS04205	COG0444	Belongs to the ABC transporter superfamily
VAPAR_RS04210	COG4608	Belongs to the ABC transporter superfamily
VAPAR_RS04215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPAR_RS04225	COG0747	negative chemotaxis
VAPAR_RS04230	COG0418	dihydroorotase activity
VAPAR_RS04255	COG0501	Belongs to the peptidase M48B family
VAPAR_RS04270	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VAPAR_RS04275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPAR_RS04280	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VAPAR_RS04305	COG1566	PFAM secretion protein HlyD family protein
VAPAR_RS04315	COG2814	Major facilitator Superfamily
VAPAR_RS04325	COG1187	pseudouridine synthase activity
VAPAR_RS04330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAPAR_RS04335	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS04385	COG0662	Cupin 2, conserved barrel domain protein
VAPAR_RS04385	COG2207	Transcriptional regulator
VAPAR_RS04410	COG1484	DNA-dependent DNA replication
VAPAR_RS04450	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VAPAR_RS04465	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAPAR_RS04470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAPAR_RS04475	COG0523	cobalamin synthesis protein
VAPAR_RS04495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VAPAR_RS04500	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VAPAR_RS04505	COG2001	Belongs to the MraZ family
VAPAR_RS04510	COG0275	rRNA processing
VAPAR_RS04515	COG3116	cell division
VAPAR_RS04525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAPAR_RS04530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAPAR_RS04535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VAPAR_RS04540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VAPAR_RS04545	COG0772	Belongs to the SEDS family
VAPAR_RS04550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAPAR_RS04555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAPAR_RS04560	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAPAR_RS04565	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VAPAR_RS04580	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VAPAR_RS04590	COG0583	DNA-binding transcription factor activity
VAPAR_RS04595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAPAR_RS04600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VAPAR_RS04605	COG0575	Belongs to the CDS family
VAPAR_RS04625	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAPAR_RS04640	COG3150	esterase
VAPAR_RS04645	COG2197	response regulator
VAPAR_RS04655	COG0772	Belongs to the SEDS family
VAPAR_RS04660	COG0312	modulator of DNA gyrase
VAPAR_RS04670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAPAR_RS04680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAPAR_RS04690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAPAR_RS04695	COG0511	ligase activity, forming carbon-carbon bonds
VAPAR_RS04700	COG0439	Biotin carboxylase
VAPAR_RS04705	COG2264	protein methyltransferase activity
VAPAR_RS04715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAPAR_RS04725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAPAR_RS04730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAPAR_RS04730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAPAR_RS04760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VAPAR_RS04765	COG2943	transferase activity, transferring hexosyl groups
VAPAR_RS04775	COG2204	response regulator
VAPAR_RS04785	COG2205	protein histidine kinase activity
VAPAR_RS04790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAPAR_RS04805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPAR_RS04820	COG0037	tRNA processing
VAPAR_RS04840	COG2175	clavaminate synthase activity
VAPAR_RS04865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPAR_RS04875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
VAPAR_RS04880	COG3387	PFAM Glycoside hydrolase 15-related
VAPAR_RS04890	COG0617	tRNA 3'-terminal CCA addition
VAPAR_RS04900	COG0625	glutathione transferase activity
VAPAR_RS04905	COG1285	pathogenesis
VAPAR_RS04910	COG0741	lytic transglycosylase activity
VAPAR_RS04915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VAPAR_RS04920	COG0583	DNA-binding transcription factor activity
VAPAR_RS04935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPAR_RS04945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAPAR_RS04950	COG1522	sequence-specific DNA binding
VAPAR_RS04960	COG3177	Filamentation induced by cAMP protein fic
VAPAR_RS04965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAPAR_RS05015	COG3411	Ferredoxin
VAPAR_RS05055	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
VAPAR_RS05080	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS05090	COG0583	DNA-binding transcription factor activity
VAPAR_RS05100	COG2951	lytic endotransglycosylase activity
VAPAR_RS05125	COG0697	spore germination
VAPAR_RS05135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAPAR_RS05150	COG3386	PFAM SMP-30 Gluconolaconase
VAPAR_RS05155	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS05165	COG1012	belongs to the aldehyde dehydrogenase family
VAPAR_RS05170	COG1879	ABC-type sugar transport system periplasmic component
VAPAR_RS05175	COG4213	ABC transporter substrate-binding protein
VAPAR_RS05185	COG4214	carbohydrate transport
VAPAR_RS05190	COG1129	ABC transporter
VAPAR_RS05195	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS05200	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS05215	COG0583	DNA-binding transcription factor activity
VAPAR_RS05220	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS05240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAPAR_RS05240	COG0189	ligase activity
VAPAR_RS05245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAPAR_RS05245	COG0189	ligase activity
VAPAR_RS05250	COG1132	(ABC) transporter
VAPAR_RS05265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VAPAR_RS05270	COG4178	(ABC) transporter
VAPAR_RS05280	COG2271	Major facilitator Superfamily
VAPAR_RS05360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAPAR_RS05375	COG1765	OsmC-like protein
VAPAR_RS05380	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
VAPAR_RS05395	COG1473	amidohydrolase
VAPAR_RS05400	COG0747	negative chemotaxis
VAPAR_RS05405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPAR_RS05410	COG0444	Belongs to the ABC transporter superfamily
VAPAR_RS05415	COG4608	Belongs to the ABC transporter superfamily
VAPAR_RS05420	COG3384	dioxygenase
VAPAR_RS05425	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VAPAR_RS05430	COG1840	ABC-type Fe3 transport system, periplasmic component
VAPAR_RS05440	COG3842	ATPase activity
VAPAR_RS05455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VAPAR_RS05460	COG0166	Belongs to the GPI family
VAPAR_RS05490	COG1175	transmembrane transport
VAPAR_RS05495	COG0395	ABC-type sugar transport system, permease component
VAPAR_RS05500	COG3842	ATPase activity
VAPAR_RS05505	COG0246	Mannitol dehydrogenase
VAPAR_RS05515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VAPAR_RS05525	COG2207	Transcriptional regulator
VAPAR_RS05525	COG4753	response regulator
VAPAR_RS05530	COG1070	Carbohydrate kinase
VAPAR_RS05535	COG0459	protein refolding
VAPAR_RS05540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VAPAR_RS05550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPAR_RS05570	COG4772	TonB-dependent receptor
VAPAR_RS05575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAPAR_RS05585	COG1560	Kdo2-lipid A biosynthetic process
VAPAR_RS05595	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VAPAR_RS05605	COG1333	cytochrome c biogenesis protein
VAPAR_RS05610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAPAR_RS05615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VAPAR_RS05620	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
VAPAR_RS05625	COG0019	diaminopimelate decarboxylase activity
VAPAR_RS05635	COG1965	Belongs to the frataxin family
VAPAR_RS05670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAPAR_RS05675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VAPAR_RS05680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VAPAR_RS05705	COG0067	glutamate synthase
VAPAR_RS05705	COG0069	glutamate synthase activity
VAPAR_RS05705	COG0070	glutamate synthase
VAPAR_RS05715	COG1127	ABC transporter
VAPAR_RS05720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAPAR_RS05725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAPAR_RS05730	COG2853	Lipoprotein
VAPAR_RS05745	COG1131	(ABC) transporter
VAPAR_RS05750	COG0842	Transport permease protein
VAPAR_RS05755	COG5007	Belongs to the BolA IbaG family
VAPAR_RS05760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAPAR_RS05765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VAPAR_RS05770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VAPAR_RS05780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPAR_RS05785	COG0131	Imidazoleglycerol-phosphate dehydratase
VAPAR_RS05795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VAPAR_RS05810	COG1301	dicarboxylic acid transport
VAPAR_RS05820	COG0107	imidazoleglycerol-phosphate synthase activity
VAPAR_RS05825	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VAPAR_RS05830	COG0140	phosphoribosyl-ATP diphosphatase activity
VAPAR_RS05840	COG0537	adenosine 5'-monophosphoramidase activity
VAPAR_RS05845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAPAR_RS05850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAPAR_RS05855	COG0805	protein transport
VAPAR_RS05870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VAPAR_RS05875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VAPAR_RS05880	COG1970	mechanosensitive ion channel activity
VAPAR_RS05890	COG1596	polysaccharide export
VAPAR_RS05900	COG0489	protein tyrosine kinase activity
VAPAR_RS05900	COG3206	protein involved in exopolysaccharide biosynthesis
VAPAR_RS05930	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPAR_RS05945	COG0723	plastoquinol--plastocyanin reductase activity
VAPAR_RS05950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VAPAR_RS05955	COG2857	Cytochrome c1
VAPAR_RS05960	COG0625	glutathione transferase activity
VAPAR_RS05965	COG2969	positive regulation of protein catabolic process
VAPAR_RS05985	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS05990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VAPAR_RS06000	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAPAR_RS06005	COG1136	(ABC) transporter
VAPAR_RS06010	COG0740	serine-type endopeptidase activity
VAPAR_RS06025	COG0601	transmembrane transport
VAPAR_RS06055	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VAPAR_RS06060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPAR_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS06080	COG2030	dehydratase
VAPAR_RS06080	COG1012	belongs to the aldehyde dehydrogenase family
VAPAR_RS06105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAPAR_RS06110	COG2151	metal-sulfur cluster biosynthetic enzyme
VAPAR_RS06115	COG3396	Phenylacetate-CoA oxygenase
VAPAR_RS06120	COG3460	Phenylacetate-CoA oxygenase
VAPAR_RS06125	COG3396	Phenylacetate-CoA oxygenase
VAPAR_RS06135	COG2050	protein possibly involved in aromatic compounds catabolism
VAPAR_RS06140	COG1024	Enoyl-CoA hydratase
VAPAR_RS06150	COG1309	transcriptional regulator
VAPAR_RS06155	COG2304	oxidoreductase activity
VAPAR_RS06165	COG0714	Associated with various cellular activities
VAPAR_RS06170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAPAR_RS06175	COG0084	hydrolase, TatD family'
VAPAR_RS06190	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VAPAR_RS06195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAPAR_RS06210	COG0583	DNA-binding transcription factor activity
VAPAR_RS06230	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS06250	COG1283	sodium-dependent phosphate transmembrane transporter activity
VAPAR_RS06260	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAPAR_RS06280	COG1609	Transcriptional regulator
VAPAR_RS06285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VAPAR_RS06295	COG0196	riboflavin kinase activity
VAPAR_RS06320	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS06325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VAPAR_RS06345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAPAR_RS06345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VAPAR_RS06355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VAPAR_RS06360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VAPAR_RS06365	COG0492	ferredoxin-NADP+ reductase activity
VAPAR_RS06375	COG1674	ftsk spoiiie
VAPAR_RS06380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VAPAR_RS06385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VAPAR_RS06390	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS06415	COG0543	2 iron, 2 sulfur cluster binding
VAPAR_RS06415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAPAR_RS06440	COG2816	NAD+ diphosphatase activity
VAPAR_RS06445	COG0425	Belongs to the sulfur carrier protein TusA family
VAPAR_RS06455	COG0525	valine-tRNA ligase activity
VAPAR_RS06460	COG3022	response to hydroperoxide
VAPAR_RS06470	COG2267	carboxylic ester hydrolase activity
VAPAR_RS06475	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAPAR_RS06475	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAPAR_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS06495	COG4948	Mandelate Racemase Muconate Lactonizing
VAPAR_RS06500	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS06515	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS06525	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS06535	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS06570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VAPAR_RS06605	COG0477	Major facilitator Superfamily
VAPAR_RS06610	COG1304	FMN binding
VAPAR_RS06615	COG0583	DNA-binding transcription factor activity
VAPAR_RS06630	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
VAPAR_RS06635	COG4221	oxidoreductase activity
VAPAR_RS06640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPAR_RS06645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPAR_RS06660	COG2807	transmembrane transport
VAPAR_RS06665	COG2186	Transcriptional regulator
VAPAR_RS06680	COG1280	lysine exporter protein (LysE YggA)
VAPAR_RS06695	COG1247	-acetyltransferase
VAPAR_RS06700	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
VAPAR_RS06725	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VAPAR_RS06760	COG0165	Argininosuccinate lyase
VAPAR_RS06765	COG3275	phosphorelay sensor kinase activity
VAPAR_RS06805	COG0583	DNA-binding transcription factor activity
VAPAR_RS06820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VAPAR_RS06825	COG0181	hydroxymethylbilane synthase activity
VAPAR_RS06845	COG1530	ribonuclease E activity
VAPAR_RS06865	COG0616	signal peptide processing
VAPAR_RS06865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAPAR_RS06870	COG2223	nitrite transmembrane transporter activity
VAPAR_RS06875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAPAR_RS06880	COG0424	maF-like protein
VAPAR_RS06885	COG1399	metal-binding, possibly nucleic acid-binding protein
VAPAR_RS06890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VAPAR_RS06895	COG0416	fatty acid biosynthetic process
VAPAR_RS06900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAPAR_RS06910	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS06915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAPAR_RS06920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAPAR_RS06945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAPAR_RS06950	COG0481	GTPase activity
VAPAR_RS06955	COG0681	Belongs to the peptidase S26 family
VAPAR_RS06965	COG0571	ribonuclease III activity
VAPAR_RS06970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VAPAR_RS06975	COG1381	Involved in DNA repair and RecF pathway recombination
VAPAR_RS06980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VAPAR_RS06985	COG0736	holo-[acyl-carrier-protein] synthase activity
VAPAR_RS06990	COG1472	Belongs to the glycosyl hydrolase 3 family
VAPAR_RS06995	COG1451	nucleotide metabolic process
VAPAR_RS07000	COG0443	Heat shock 70 kDa protein
VAPAR_RS07005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VAPAR_RS07015	COG0762	integral membrane protein
VAPAR_RS07020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAPAR_RS07025	COG0159	tryptophan synthase activity
VAPAR_RS07030	COG0133	tryptophan synthase activity
VAPAR_RS07035	COG0135	phosphoribosylanthranilate isomerase activity
VAPAR_RS07040	COG0101	tRNA pseudouridine synthase activity
VAPAR_RS07050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAPAR_RS07055	COG0473	3-isopropylmalate dehydrogenase activity
VAPAR_RS07060	COG0066	3-isopropylmalate dehydratase activity
VAPAR_RS07065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAPAR_RS07080	COG0372	Belongs to the citrate synthase family
VAPAR_RS07085	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VAPAR_RS07090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VAPAR_RS07095	COG1053	succinate dehydrogenase
VAPAR_RS07110	COG2188	Transcriptional regulator
VAPAR_RS07115	COG0039	L-malate dehydrogenase activity
VAPAR_RS07120	COG4106	trans-aconitate 2-methyltransferase activity
VAPAR_RS07155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VAPAR_RS07180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPAR_RS07190	COG3483	tryptophan 2,3-dioxygenase activity
VAPAR_RS07200	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VAPAR_RS07210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VAPAR_RS07215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAPAR_RS07225	COG0268	Binds directly to 16S ribosomal RNA
VAPAR_RS07230	COG0728	peptidoglycan biosynthetic process
VAPAR_RS07245	COG3795	YCII-related domain
VAPAR_RS07250	COG3795	YCII-related domain
VAPAR_RS07255	COG4941	Belongs to the sigma-70 factor family
VAPAR_RS07260	COG1917	Cupin 2, conserved barrel domain protein
VAPAR_RS07260	COG4977	sequence-specific DNA binding
VAPAR_RS07280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VAPAR_RS07285	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VAPAR_RS07290	COG0617	tRNA 3'-terminal CCA addition
VAPAR_RS07300	COG1392	Phosphate transport regulator
VAPAR_RS07305	COG0306	phosphate transporter
VAPAR_RS07320	COG0228	four-way junction DNA binding
VAPAR_RS07325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VAPAR_RS07330	COG0336	Belongs to the RNA methyltransferase TrmD family
VAPAR_RS07335	COG0335	large ribosomal subunit rRNA binding
VAPAR_RS07345	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VAPAR_RS07350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPAR_RS07355	COG1162	GTPase activity
VAPAR_RS07360	COG2154	pterin-4-alpha-carbinolamine dehydratase
VAPAR_RS07365	COG0501	Belongs to the peptidase M48B family
VAPAR_RS07370	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VAPAR_RS07375	COG0513	Belongs to the DEAD box helicase family
VAPAR_RS07380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAPAR_RS07385	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPAR_RS07395	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS07395	COG3321	synthase
VAPAR_RS07395	COG0604	alcohol dehydrogenase
VAPAR_RS07420	COG4638	Rieske (2fe-2S)
VAPAR_RS07445	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
VAPAR_RS07485	COG0411	ABC transporter
VAPAR_RS07505	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS07550	COG4964	Belongs to the GSP D family
VAPAR_RS07610	COG2197	response regulator
VAPAR_RS07630	COG0516	GMP reductase activity
VAPAR_RS07635	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VAPAR_RS07640	COG0210	DNA helicase
VAPAR_RS07660	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAPAR_RS07690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPAR_RS07700	COG0412	Dienelactone hydrolase
VAPAR_RS07715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VAPAR_RS07720	COG4608	Belongs to the ABC transporter superfamily
VAPAR_RS07725	COG0444	Belongs to the ABC transporter superfamily
VAPAR_RS07730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPAR_RS07735	COG0601	transmembrane transport
VAPAR_RS07740	COG0747	negative chemotaxis
VAPAR_RS07765	COG3064	Membrane
VAPAR_RS07805	COG1722	exodeoxyribonuclease VII activity
VAPAR_RS07810	COG0142	geranyltranstransferase activity
VAPAR_RS07815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VAPAR_RS07820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAPAR_RS07825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPAR_RS07835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAPAR_RS07840	COG0477	Major facilitator Superfamily
VAPAR_RS07845	COG1910	domain protein
VAPAR_RS07860	COG2188	Transcriptional regulator
VAPAR_RS07870	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS07905	COG1122	ATPase activity
VAPAR_RS07940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAPAR_RS07955	COG3608	succinylglutamate desuccinylase aspartoacylase
VAPAR_RS07955	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
VAPAR_RS07960	COG1320	monovalent cation:proton antiporter activity
VAPAR_RS07965	COG2212	antiporter activity
VAPAR_RS07975	COG0651	ATP synthesis coupled electron transport
VAPAR_RS07980	COG1006	Multisubunit Na H antiporter MnhC subunit
VAPAR_RS07985	COG2111	Na H antiporter
VAPAR_RS07985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAPAR_RS07990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VAPAR_RS08005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPAR_RS08015	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VAPAR_RS08035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VAPAR_RS08040	COG0287	Prephenate dehydrogenase
VAPAR_RS08045	COG1605	Chorismate mutase
VAPAR_RS08045	COG0077	Prephenate dehydratase
VAPAR_RS08050	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VAPAR_RS08070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAPAR_RS08080	COG4797	methyltransferase
VAPAR_RS08080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAPAR_RS08090	COG1187	pseudouridine synthase activity
VAPAR_RS08115	COG1058	Belongs to the CinA family
VAPAR_RS08115	COG1546	Belongs to the CinA family
VAPAR_RS08120	COG0174	glutamine synthetase
VAPAR_RS08130	COG3852	Histidine kinase
VAPAR_RS08145	COG0708	Exodeoxyribonuclease III
VAPAR_RS08170	COG0583	DNA-binding transcription factor activity
VAPAR_RS08180	COG0583	DNA-binding transcription factor activity
VAPAR_RS08185	COG4948	Mandelate Racemase Muconate Lactonizing
VAPAR_RS08195	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
VAPAR_RS08205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPAR_RS08235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VAPAR_RS08245	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
VAPAR_RS08250	COG5002	protein histidine kinase activity
VAPAR_RS08255	COG0392	lysyltransferase activity
VAPAR_RS08280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAPAR_RS08300	COG0277	FAD linked oxidase domain protein
VAPAR_RS08310	COG1295	ribonuclease BN
VAPAR_RS08320	COG3118	belongs to the thioredoxin family
VAPAR_RS08325	COG0702	epimerase
VAPAR_RS08330	COG0583	DNA-binding transcription factor activity
VAPAR_RS08340	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS08345	COG2267	carboxylic ester hydrolase activity
VAPAR_RS08365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAPAR_RS08370	COG0583	DNA-binding transcription factor activity
VAPAR_RS08390	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS08395	COG4638	Rieske (2fe-2S)
VAPAR_RS08430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VAPAR_RS08450	COG3070	regulator of competence-specific genes
VAPAR_RS08455	COG0346	lactoylglutathione lyase activity
VAPAR_RS08465	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VAPAR_RS08470	COG0596	Alpha beta hydrolase
VAPAR_RS08480	COG0625	glutathione transferase activity
VAPAR_RS08495	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VAPAR_RS08500	COG2719	SpoVR family
VAPAR_RS08505	COG2718	Belongs to the UPF0229 family
VAPAR_RS08510	COG2766	serine protein kinase
VAPAR_RS08515	COG0484	heat shock protein binding
VAPAR_RS08520	COG0443	Heat shock 70 kDa protein
VAPAR_RS08525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VAPAR_RS08540	COG0688	phosphatidylethanolamine metabolic process
VAPAR_RS08545	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS08550	COG2706	6-phosphogluconolactonase activity
VAPAR_RS08565	COG2721	sulfolactate sulfo-lyase activity
VAPAR_RS08570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPAR_RS08580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPAR_RS08590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPAR_RS08595	COG2186	Transcriptional regulator
VAPAR_RS08600	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS08605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPAR_RS08620	COG1012	belongs to the aldehyde dehydrogenase family
VAPAR_RS08645	COG0842	Transport permease protein
VAPAR_RS08650	COG0842	Transport permease protein
VAPAR_RS08655	COG1131	(ABC) transporter
VAPAR_RS08670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPAR_RS08680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAPAR_RS08685	COG1802	Transcriptional regulator
VAPAR_RS08715	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VAPAR_RS08730	COG0583	DNA-binding transcription factor activity
VAPAR_RS08735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPAR_RS08740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS08760	COG2814	Major facilitator Superfamily
VAPAR_RS08770	COG0358	DNA primase activity
VAPAR_RS08775	COG1295	ribonuclease BN
VAPAR_RS08775	COG1959	2 iron, 2 sulfur cluster binding
VAPAR_RS08790	COG0123	including yeast histone deacetylase and acetoin utilization protein
VAPAR_RS08795	COG0824	Thioesterase
VAPAR_RS08805	COG3237	CsbD-like
VAPAR_RS08810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VAPAR_RS08820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPAR_RS08835	COG1611	Belongs to the LOG family
VAPAR_RS08840	COG1024	Enoyl-CoA hydratase
VAPAR_RS08845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAPAR_RS08860	COG0405	Gamma-glutamyltransferase
VAPAR_RS08865	COG0322	excinuclease ABC activity
VAPAR_RS08880	COG0583	DNA-binding transcription factor activity
VAPAR_RS08885	COG0596	Alpha beta hydrolase
VAPAR_RS08890	COG0473	3-isopropylmalate dehydrogenase activity
VAPAR_RS08905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAPAR_RS08945	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VAPAR_RS08950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAPAR_RS08965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAPAR_RS08970	COG0670	Belongs to the BI1 family
VAPAR_RS08975	COG3193	protein, possibly involved in utilization of glycolate and propanediol
VAPAR_RS09000	COG4774	siderophore transport
VAPAR_RS09005	COG3128	pkhd-type hydroxylase
VAPAR_RS09035	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VAPAR_RS09050	COG0360	Binds together with S18 to 16S ribosomal RNA
VAPAR_RS09055	COG2965	DNA replication, synthesis of RNA primer
VAPAR_RS09060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VAPAR_RS09065	COG0359	binds to the 23S rRNA
VAPAR_RS09070	COG0305	Participates in initiation and elongation during chromosome replication
VAPAR_RS09095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VAPAR_RS09100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VAPAR_RS09110	COG0436	Aminotransferase
VAPAR_RS09120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VAPAR_RS09125	COG1763	Mo-molybdopterin cofactor biosynthetic process
VAPAR_RS09130	COG0303	'Molybdopterin
VAPAR_RS09135	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VAPAR_RS09140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPAR_RS09145	COG0314	molybdopterin synthase activity
VAPAR_RS09150	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS09155	COG0542	response to heat
VAPAR_RS09165	COG0183	Belongs to the thiolase family
VAPAR_RS09180	COG0659	secondary active sulfate transmembrane transporter activity
VAPAR_RS09190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAPAR_RS09195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAPAR_RS09230	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VAPAR_RS09235	COG3214	Protein conserved in bacteria
VAPAR_RS09250	COG0673	inositol 2-dehydrogenase activity
VAPAR_RS09265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS09270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS09280	COG1309	transcriptional regulator
VAPAR_RS09285	COG0028	Belongs to the TPP enzyme family
VAPAR_RS09310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VAPAR_RS09315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VAPAR_RS09320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VAPAR_RS09325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VAPAR_RS09330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VAPAR_RS09335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAPAR_RS09335	COG0072	phenylalanine-tRNA ligase activity
VAPAR_RS09340	COG0776	regulation of translation
VAPAR_RS09375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPAR_RS09390	COG1126	abc transporter atp-binding protein
VAPAR_RS09395	COG0765	amino acid transport
VAPAR_RS09415	COG1045	serine acetyltransferase
VAPAR_RS09425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPAR_RS09430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAPAR_RS09455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS09485	COG1464	Belongs to the NlpA lipoprotein family
VAPAR_RS09500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPAR_RS09510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS09515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS09530	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS09530	COG2205	protein histidine kinase activity
VAPAR_RS09530	COG4191	Histidine kinase
VAPAR_RS09535	COG0583	DNA-binding transcription factor activity
VAPAR_RS09540	COG1335	isochorismatase
VAPAR_RS09580	COG1596	polysaccharide export
VAPAR_RS09585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VAPAR_RS09605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAPAR_RS09620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAPAR_RS09635	COG0489	protein tyrosine kinase activity
VAPAR_RS09635	COG3206	protein involved in exopolysaccharide biosynthesis
VAPAR_RS09640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAPAR_RS09645	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAPAR_RS09660	COG1850	ribulose-bisphosphate carboxylase activity
VAPAR_RS09670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPAR_RS09675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPAR_RS09680	COG1609	Transcriptional regulator
VAPAR_RS09690	COG1012	belongs to the aldehyde dehydrogenase family
VAPAR_RS09695	COG2721	sulfolactate sulfo-lyase activity
VAPAR_RS09730	COG0431	NADPH-dependent FMN reductase
VAPAR_RS09745	COG0798	PFAM Bile acid sodium symporter
VAPAR_RS09755	COG3287	FIST C domain
VAPAR_RS09755	COG2200	EAL domain
VAPAR_RS09755	COG2199	diguanylate cyclase activity
VAPAR_RS09760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAPAR_RS09775	COG0366	Alpha amylase catalytic
VAPAR_RS09815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAPAR_RS09820	COG0366	Alpha amylase catalytic
VAPAR_RS09825	COG0366	Alpha amylase catalytic
VAPAR_RS09840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAPAR_RS09845	COG1640	4-alpha-glucanotransferase
VAPAR_RS09860	COG1396	sequence-specific DNA binding
VAPAR_RS09885	COG2226	methyltransferase
VAPAR_RS09890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPAR_RS09895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VAPAR_RS09895	COG2010	Cytochrome c
VAPAR_RS09925	COG0028	Belongs to the TPP enzyme family
VAPAR_RS09935	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VAPAR_RS09940	COG1335	isochorismatase
VAPAR_RS09985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPAR_RS09995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPAR_RS10005	COG3045	CreA protein
VAPAR_RS10035	COG3243	poly(R)-hydroxyalkanoic acid synthase
VAPAR_RS10040	COG0183	Belongs to the thiolase family
VAPAR_RS10045	COG0583	DNA-binding transcription factor activity
VAPAR_RS10055	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
VAPAR_RS10075	COG1058	Belongs to the CinA family
VAPAR_RS10075	COG1546	Belongs to the CinA family
VAPAR_RS10080	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS10085	COG1301	dicarboxylic acid transport
VAPAR_RS10090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAPAR_RS10090	COG4651	solute:proton antiporter activity
VAPAR_RS10135	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS10145	COG2249	NAD(P)H dehydrogenase (quinone) activity
VAPAR_RS10150	COG0583	DNA-binding transcription factor activity
VAPAR_RS10165	COG0028	Belongs to the TPP enzyme family
VAPAR_RS10190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAPAR_RS10200	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VAPAR_RS10270	COG4171	peptide transport system, permease
VAPAR_RS10275	COG4172	Belongs to the ABC transporter superfamily
VAPAR_RS10290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
VAPAR_RS10300	COG1475	DNA binding
VAPAR_RS10310	COG5489	Protein of unknown function (DUF736)
VAPAR_RS10345	COG1192	Involved in chromosome partitioning
VAPAR_RS10375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS10380	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS10385	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS10390	COG0583	DNA-binding transcription factor activity
VAPAR_RS10420	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS10425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VAPAR_RS10510	COG1802	Transcriptional regulator
VAPAR_RS10515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VAPAR_RS10515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VAPAR_RS10525	COG1703	isobutyryl-CoA mutase activity
VAPAR_RS10530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAPAR_RS10535	COG4770	biotin carboxylase activity
VAPAR_RS10540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAPAR_RS10550	COG1522	sequence-specific DNA binding
VAPAR_RS10555	COG0697	spore germination
VAPAR_RS10565	COG2878	Part of a membrane complex involved in electron transport
VAPAR_RS10580	COG0556	nucleotide-excision repair
VAPAR_RS10585	COG1959	2 iron, 2 sulfur cluster binding
VAPAR_RS10590	COG1104	cysteine desulfurase activity
VAPAR_RS10595	COG0822	iron-sulfur transferase activity
VAPAR_RS10610	COG0443	Heat shock 70 kDa protein
VAPAR_RS10615	COG0633	Ferredoxin
VAPAR_RS10645	COG0579	oxidoreductase
VAPAR_RS10660	COG0167	dihydroorotate dehydrogenase activity
VAPAR_RS10665	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VAPAR_RS10680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VAPAR_RS10685	COG4566	intracellular signal transduction
VAPAR_RS10695	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VAPAR_RS10700	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAPAR_RS10705	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VAPAR_RS10710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAPAR_RS10715	COG0791	NLP P60 protein
VAPAR_RS10720	COG2133	pyrroloquinoline quinone binding
VAPAR_RS10740	COG0567	Dehydrogenase, E1 component
VAPAR_RS10745	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAPAR_RS10750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAPAR_RS10755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VAPAR_RS10775	COG1199	ATP-dependent helicase activity
VAPAR_RS10785	COG0564	pseudouridine synthase activity
VAPAR_RS10790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VAPAR_RS10795	COG1187	pseudouridine synthase activity
VAPAR_RS10800	COG0105	UTP biosynthetic process
VAPAR_RS10805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VAPAR_RS10820	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VAPAR_RS10825	COG0124	histidyl-tRNA synthetase
VAPAR_RS10840	COG1160	GTP binding
VAPAR_RS10845	COG1923	regulation of RNA biosynthetic process
VAPAR_RS10850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VAPAR_RS10855	COG0330	HflC and HflK could
VAPAR_RS10860	COG0330	HflC and HflK could
VAPAR_RS10870	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
VAPAR_RS10875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VAPAR_RS10900	COG0626	cystathionine gamma-synthase activity
VAPAR_RS10915	COG1136	(ABC) transporter
VAPAR_RS10925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAPAR_RS10950	COG0667	Aldo Keto reductase
VAPAR_RS10955	COG2059	Chromate
VAPAR_RS10965	COG1295	ribonuclease BN
VAPAR_RS10985	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS11030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS11055	COG1024	Enoyl-CoA hydratase
VAPAR_RS11175	COG1987	bacterial-type flagellum assembly
VAPAR_RS11180	COG1684	flagellar biosynthetic protein fliR
VAPAR_RS11185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VAPAR_RS11190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VAPAR_RS11195	COG4786	Flagellar basal body rod
VAPAR_RS11200	COG4786	Flagellar basal body rod
VAPAR_RS11210	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VAPAR_RS11215	COG1706	bacterial-type flagellum-dependent cell motility
VAPAR_RS11225	COG1558	bacterial-type flagellum-dependent cell motility
VAPAR_RS11230	COG1677	Flagellar hook-basal body complex protein FliE
VAPAR_RS11250	COG1157	protein secretion by the type III secretion system
VAPAR_RS11265	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VAPAR_RS11295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAPAR_RS11355	COG3039	Transposase
VAPAR_RS11385	COG0582	viral genome integration into host DNA
VAPAR_RS11405	COG0625	glutathione transferase activity
VAPAR_RS11410	COG0492	ferredoxin-NADP+ reductase activity
VAPAR_RS11445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAPAR_RS11450	COG0573	inorganic phosphate transmembrane transporter activity
VAPAR_RS11455	COG0581	inorganic phosphate transmembrane transporter activity
VAPAR_RS11460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAPAR_RS11480	COG0534	Mate efflux family protein
VAPAR_RS11490	COG0254	rRNA binding
VAPAR_RS11495	COG0673	inositol 2-dehydrogenase activity
VAPAR_RS11500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VAPAR_RS11515	COG1074	ATP-dependent DNA helicase activity
VAPAR_RS11545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VAPAR_RS11550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VAPAR_RS11560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS11570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS11575	COG1388	LysM domain
VAPAR_RS11575	COG0741	lytic transglycosylase activity
VAPAR_RS11580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAPAR_RS11585	COG2226	methyltransferase
VAPAR_RS11590	COG0328	RNA-DNA hybrid ribonuclease activity
VAPAR_RS11595	COG0303	'Molybdopterin
VAPAR_RS11600	COG0746	molybdenum cofactor guanylyltransferase activity
VAPAR_RS11605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VAPAR_RS11610	COG1012	belongs to the aldehyde dehydrogenase family
VAPAR_RS11620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPAR_RS11680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VAPAR_RS11705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAPAR_RS11730	COG0028	Belongs to the TPP enzyme family
VAPAR_RS11735	COG0440	acetolactate synthase activity
VAPAR_RS11745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VAPAR_RS11750	COG1183	phosphatidylcholine synthase activity
VAPAR_RS11755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPAR_RS11760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPAR_RS11770	COG1414	Transcriptional regulator
VAPAR_RS11775	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VAPAR_RS11780	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VAPAR_RS11805	COG1414	Transcriptional regulator
VAPAR_RS11820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAPAR_RS11860	COG4773	Receptor
VAPAR_RS11870	COG2022	thiamine diphosphate biosynthetic process
VAPAR_RS11885	COG0351	phosphomethylpyrimidine kinase
VAPAR_RS11900	COG0492	ferredoxin-NADP+ reductase activity
VAPAR_RS11905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VAPAR_RS11910	COG2895	sulfate adenylyltransferase (ATP) activity
VAPAR_RS11910	COG0529	Catalyzes the synthesis of activated sulfate
VAPAR_RS11935	COG2801	Transposase and inactivated derivatives
VAPAR_RS11935	COG3415	Transposase
VAPAR_RS11960	COG2204	response regulator
VAPAR_RS11980	COG0411	ABC transporter
VAPAR_RS12010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VAPAR_RS12245	COG0740	serine-type endopeptidase activity
VAPAR_RS12375	COG1011	Hydrolase
VAPAR_RS12390	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
VAPAR_RS12395	COG1562	ergosterol biosynthetic process
VAPAR_RS12410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPAR_RS12425	COG0544	peptidyl-prolyl cis-trans isomerase activity
VAPAR_RS12430	COG0740	serine-type endopeptidase activity
VAPAR_RS12435	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VAPAR_RS12440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAPAR_RS12475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VAPAR_RS12485	COG2113	Glycine betaine
VAPAR_RS12490	COG4176	ABC-type proline glycine betaine transport system permease component
VAPAR_RS12500	COG0114	fumarate hydratase activity
VAPAR_RS12505	COG2910	NAD(P)H-binding
VAPAR_RS12510	COG0583	DNA-binding transcription factor activity
VAPAR_RS12520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAPAR_RS12530	COG4654	Cytochrome c, class I
VAPAR_RS12540	COG0129	dihydroxy-acid dehydratase activity
VAPAR_RS12545	COG0583	DNA-binding transcription factor activity
VAPAR_RS12550	COG0583	DNA-binding transcription factor activity
VAPAR_RS12560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VAPAR_RS12565	COG1802	Transcriptional regulator
VAPAR_RS12580	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS12595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAPAR_RS12600	COG4977	sequence-specific DNA binding
VAPAR_RS12610	COG0730	response to heat
VAPAR_RS12625	COG4206	TonB-dependent receptor
VAPAR_RS12630	COG1797	cobyrinic acid a,c-diamide synthase activity
VAPAR_RS12645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAPAR_RS12650	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VAPAR_RS12655	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VAPAR_RS12660	COG0778	Nitroreductase
VAPAR_RS12670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAPAR_RS12675	COG1380	Effector of murein hydrolase LrgA
VAPAR_RS12700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPAR_RS12715	COG1492	cobalamin metabolic process
VAPAR_RS12720	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VAPAR_RS12725	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VAPAR_RS12740	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS12745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VAPAR_RS12750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPAR_RS12770	COG0560	Phosphoserine phosphatase
VAPAR_RS12775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VAPAR_RS12780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAPAR_RS12780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAPAR_RS12785	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAPAR_RS12785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAPAR_RS12810	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS12820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAPAR_RS12835	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
VAPAR_RS12840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAPAR_RS12855	COG3339	Conserved Protein
VAPAR_RS12870	COG0557	exoribonuclease II activity
VAPAR_RS12875	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS12880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VAPAR_RS12880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VAPAR_RS12895	COG0052	Belongs to the universal ribosomal protein uS2 family
VAPAR_RS12900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VAPAR_RS12905	COG0528	UMP kinase activity
VAPAR_RS12910	COG0233	cytoplasmic translational termination
VAPAR_RS12925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VAPAR_RS12930	COG0750	zinc metalloprotease
VAPAR_RS12945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPAR_RS12950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAPAR_RS12955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPAR_RS12960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPAR_RS12965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VAPAR_RS12970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAPAR_RS12975	COG0505	Belongs to the CarA family
VAPAR_RS12985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VAPAR_RS12995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAPAR_RS13010	COG1534	Rna-binding protein
VAPAR_RS13015	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VAPAR_RS13020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPAR_RS13030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAPAR_RS13050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPAR_RS13055	COG1024	Enoyl-CoA hydratase
VAPAR_RS13060	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPAR_RS13065	COG2814	Major facilitator Superfamily
VAPAR_RS13070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPAR_RS13080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VAPAR_RS13085	COG0252	asparaginase activity
VAPAR_RS13090	COG0563	adenylate kinase activity
VAPAR_RS13095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VAPAR_RS13100	COG2835	tetraacyldisaccharide 4'-kinase activity
VAPAR_RS13105	COG1663	tetraacyldisaccharide 4'-kinase activity
VAPAR_RS13110	COG0848	biopolymer transport protein
VAPAR_RS13115	COG0811	peptide transport
VAPAR_RS13120	COG1570	exodeoxyribonuclease VII activity
VAPAR_RS13125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VAPAR_RS13150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VAPAR_RS13155	COG0542	response to heat
VAPAR_RS13160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPAR_RS13165	COG2925	Exonuclease
VAPAR_RS13170	COG0402	S-adenosylhomocysteine deaminase activity
VAPAR_RS13180	COG1079	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS13185	COG4603	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS13190	COG3845	ABC transporter
VAPAR_RS13200	COG1744	ABC transporter substrate-binding protein PnrA-like
VAPAR_RS13205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VAPAR_RS13230	COG1595	DNA-templated transcription, initiation
VAPAR_RS13240	COG0433	COG0433 Predicted ATPase
VAPAR_RS13255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAPAR_RS13310	COG2226	methyltransferase
VAPAR_RS13315	COG0217	transcriptional regulatory protein
VAPAR_RS13320	COG0151	Belongs to the GarS family
VAPAR_RS13325	COG0408	coproporphyrinogen oxidase activity
VAPAR_RS13330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VAPAR_RS13335	COG0799	negative regulation of ribosome biogenesis
VAPAR_RS13340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VAPAR_RS13345	COG0424	maF-like protein
VAPAR_RS13350	COG1530	ribonuclease E activity
VAPAR_RS13355	COG1132	(ABC) transporter
VAPAR_RS13360	COG0823	Involved in the tonB-independent uptake of proteins
VAPAR_RS13365	COG2885	chlorophyll binding
VAPAR_RS13375	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VAPAR_RS13415	COG1484	DNA-dependent DNA replication
VAPAR_RS13420	COG4584	PFAM Integrase catalytic
VAPAR_RS13480	COG0488	(ABC) transporter
VAPAR_RS13485	COG2890	protein-(glutamine-N5) methyltransferase activity
VAPAR_RS13490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPAR_RS13500	COG2171	N-acyltransferase activity
VAPAR_RS13510	COG1280	lysine exporter protein (LysE YggA)
VAPAR_RS13515	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAPAR_RS13515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAPAR_RS13520	COG1643	Atp-dependent helicase
VAPAR_RS13525	COG0436	Aminotransferase
VAPAR_RS13530	COG0583	DNA-binding transcription factor activity
VAPAR_RS13550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAPAR_RS13600	COG1793	dna ligase
VAPAR_RS13610	COG4166	transmembrane transport
VAPAR_RS13615	COG4174	ABC transporter (Permease)
VAPAR_RS13620	COG4239	(ABC) transporter, permease
VAPAR_RS13625	COG4172	Belongs to the ABC transporter superfamily
VAPAR_RS13630	COG0477	Major facilitator Superfamily
VAPAR_RS13635	COG0779	Required for maturation of 30S ribosomal subunits
VAPAR_RS13640	COG2251	uridine kinase activity
VAPAR_RS13640	COG0195	Participates in both transcription termination and antitermination
VAPAR_RS13645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VAPAR_RS13650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VAPAR_RS13655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VAPAR_RS13690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VAPAR_RS13695	COG2867	negative regulation of translational initiation
VAPAR_RS13700	COG2914	Belongs to the UPF0125 (RnfH) family
VAPAR_RS13725	COG0519	Catalyzes the synthesis of GMP from XMP
VAPAR_RS13725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VAPAR_RS13730	COG1733	regulation of RNA biosynthetic process
VAPAR_RS13735	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS13750	COG2267	carboxylic ester hydrolase activity
VAPAR_RS13780	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VAPAR_RS13795	COG0583	DNA-binding transcription factor activity
VAPAR_RS13855	COG4191	Histidine kinase
VAPAR_RS13860	COG4566	intracellular signal transduction
VAPAR_RS13890	COG1619	proteins homologs of microcin C7 resistance protein MccF
VAPAR_RS13925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAPAR_RS13935	COG1199	ATP-dependent helicase activity
VAPAR_RS13960	COG0156	8-amino-7-oxononanoate synthase activity
VAPAR_RS13965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VAPAR_RS13970	COG0667	Aldo Keto reductase
VAPAR_RS13975	COG2207	Transcriptional regulator
VAPAR_RS13985	COG2217	Heavy metal translocating P-type atpase
VAPAR_RS13995	COG3278	Belongs to the heme-copper respiratory oxidase family
VAPAR_RS14025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAPAR_RS14035	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
VAPAR_RS14050	COG0589	response to stress
VAPAR_RS14135	COG0515	serine threonine protein kinase
VAPAR_RS14135	COG2815	serine threonine protein kinase
VAPAR_RS14155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAPAR_RS14160	COG3360	Dodecin
VAPAR_RS14165	COG0432	Pfam Uncharacterised protein family UPF0047
VAPAR_RS14180	COG0666	response to abiotic stimulus
VAPAR_RS14185	COG0084	hydrolase, TatD family'
VAPAR_RS14200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAPAR_RS14205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VAPAR_RS14225	COG0657	acetylesterase activity
VAPAR_RS14285	COG2183	response to ionizing radiation
VAPAR_RS14290	COG2186	Transcriptional regulator
VAPAR_RS14305	COG1063	alcohol dehydrogenase
VAPAR_RS14310	COG0765	amino acid transport
VAPAR_RS14315	COG0765	amino acid transport
VAPAR_RS14325	COG4948	Mandelate Racemase Muconate Lactonizing
VAPAR_RS14330	COG0246	Mannitol dehydrogenase
VAPAR_RS14355	COG0534	Mate efflux family protein
VAPAR_RS14365	COG0477	Major facilitator Superfamily
VAPAR_RS14375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAPAR_RS14375	COG3008	intermembrane lipid transfer
VAPAR_RS14380	COG2995	paraquat-inducible protein a
VAPAR_RS14385	COG2995	paraquat-inducible protein a
VAPAR_RS14390	COG2814	Major facilitator Superfamily
VAPAR_RS14395	COG2814	Major facilitator Superfamily
VAPAR_RS14415	COG0583	DNA-binding transcription factor activity
VAPAR_RS14430	COG0247	lactate metabolic process
VAPAR_RS14430	COG0277	FAD linked oxidase domain protein
VAPAR_RS14455	COG0583	DNA-binding transcription factor activity
VAPAR_RS14460	COG2814	Major facilitator Superfamily
VAPAR_RS14465	COG0667	Aldo Keto reductase
VAPAR_RS14470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VAPAR_RS14490	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS14495	COG2130	NADP-dependent
VAPAR_RS14520	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS14525	COG0183	Belongs to the thiolase family
VAPAR_RS14535	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPAR_RS14535	COG1024	Enoyl-CoA hydratase
VAPAR_RS14545	COG0411	ABC transporter
VAPAR_RS14570	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS14575	COG2272	Belongs to the type-B carboxylesterase lipase family
VAPAR_RS14585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VAPAR_RS14590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAPAR_RS14595	COG2917	probably involved in intracellular septation
VAPAR_RS14605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAPAR_RS14610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VAPAR_RS14610	COG0047	phosphoribosylformylglycinamidine synthase activity
VAPAR_RS14615	COG0024	Methionine aminopeptidase
VAPAR_RS14620	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VAPAR_RS14630	COG0765	amino acid transport
VAPAR_RS14635	COG4597	amino acid ABC transporter
VAPAR_RS14640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPAR_RS14650	COG0242	peptide deformylase activity
VAPAR_RS14660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VAPAR_RS14670	COG1196	nuclear chromosome segregation
VAPAR_RS14685	COG3550	peptidyl-serine autophosphorylation
VAPAR_RS14695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VAPAR_RS14700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAPAR_RS14705	COG4208	sulfate ABC transporter
VAPAR_RS14715	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VAPAR_RS14725	COG0450	alkyl hydroperoxide reductase
VAPAR_RS14735	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VAPAR_RS14745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPAR_RS14760	COG1045	serine acetyltransferase
VAPAR_RS14770	COG2873	o-acetylhomoserine
VAPAR_RS14775	COG1116	anion transmembrane transporter activity
VAPAR_RS14780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS14785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS14790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPAR_RS14795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS14800	COG0431	NADPH-dependent FMN reductase
VAPAR_RS14810	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VAPAR_RS14815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPAR_RS14815	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAPAR_RS14835	COG5002	protein histidine kinase activity
VAPAR_RS14840	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS14845	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
VAPAR_RS14850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VAPAR_RS14860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAPAR_RS14865	COG3588	fructose-bisphosphate aldolase
VAPAR_RS14870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPAR_RS14875	COG0583	DNA-binding transcription factor activity
VAPAR_RS14890	COG0789	Transcriptional regulator
VAPAR_RS14900	COG1446	asparaginase
VAPAR_RS14905	COG4172	Belongs to the ABC transporter superfamily
VAPAR_RS14910	COG0747	negative chemotaxis
VAPAR_RS14915	COG0601	transmembrane transport
VAPAR_RS14920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPAR_RS14945	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS14955	COG0642	Histidine kinase
VAPAR_RS14965	COG2326	polyphosphate kinase activity
VAPAR_RS14990	COG3383	formate dehydrogenase (NAD+) activity
VAPAR_RS14995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAPAR_RS15005	COG0191	fructose-bisphosphate aldolase activity
VAPAR_RS15010	COG0126	phosphoglycerate kinase activity
VAPAR_RS15015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAPAR_RS15020	COG3954	Phosphoribulokinase
VAPAR_RS15025	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VAPAR_RS15035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VAPAR_RS15040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAPAR_RS15045	COG0464	growth
VAPAR_RS15055	COG1850	ribulose-bisphosphate carboxylase activity
VAPAR_RS15060	COG0583	DNA-binding transcription factor activity
VAPAR_RS15090	COG1129	ABC transporter
VAPAR_RS15090	COG0842	Transport permease protein
VAPAR_RS15100	COG2010	Cytochrome c
VAPAR_RS15130	COG0714	Associated with various cellular activities
VAPAR_RS15160	COG0535	radical SAM domain protein
VAPAR_RS15175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VAPAR_RS15185	COG3851	Histidine kinase
VAPAR_RS15190	COG2197	response regulator
VAPAR_RS15200	COG0512	Glutamine amidotransferase of anthranilate synthase
VAPAR_RS15200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAPAR_RS15215	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
VAPAR_RS15220	COG1229	Formylmethanofuran dehydrogenase subunit A
VAPAR_RS15270	COG3284	Transcriptional regulator
VAPAR_RS15280	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
VAPAR_RS15295	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
VAPAR_RS15305	COG0702	epimerase
VAPAR_RS15320	COG0527	aspartate kinase activity
VAPAR_RS15325	COG0037	tRNA processing
VAPAR_RS15330	COG0825	malonyl-CoA metabolic process
VAPAR_RS15340	COG0215	cysteine-tRNA ligase activity
VAPAR_RS15360	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAPAR_RS15380	COG0741	lytic transglycosylase activity
VAPAR_RS15385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAPAR_RS15390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAPAR_RS15425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAPAR_RS15425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAPAR_RS15440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VAPAR_RS15445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAPAR_RS15450	COG0436	Aminotransferase
VAPAR_RS15455	COG0824	Thioesterase
VAPAR_RS15465	COG0848	biopolymer transport protein
VAPAR_RS15480	COG1054	Belongs to the UPF0176 family
VAPAR_RS15485	COG1741	Belongs to the pirin family
VAPAR_RS15500	COG1741	Belongs to the pirin family
VAPAR_RS15510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAPAR_RS15510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPAR_RS15515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAPAR_RS15520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VAPAR_RS15530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPAR_RS15550	COG3976	FMN-binding domain protein
VAPAR_RS15550	COG1053	succinate dehydrogenase
VAPAR_RS15550	COG0431	NADPH-dependent FMN reductase
VAPAR_RS15595	COG3842	ATPase activity
VAPAR_RS15615	COG0784	Response regulator, receiver
VAPAR_RS15615	COG2198	Histidine kinase
VAPAR_RS15615	COG2205	protein histidine kinase activity
VAPAR_RS15640	COG2207	Transcriptional regulator
VAPAR_RS15660	COG0308	aminopeptidase N
VAPAR_RS15665	COG2271	Major facilitator Superfamily
VAPAR_RS15705	COG1012	belongs to the aldehyde dehydrogenase family
VAPAR_RS15710	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
VAPAR_RS15715	COG0028	Belongs to the TPP enzyme family
VAPAR_RS15725	COG1414	Transcriptional regulator
VAPAR_RS15740	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS15745	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS15750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPAR_RS15755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPAR_RS15760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAPAR_RS15830	COG1596	polysaccharide export
VAPAR_RS15835	COG3206	protein involved in exopolysaccharide biosynthesis
VAPAR_RS15835	COG0489	protein tyrosine kinase activity
VAPAR_RS15840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAPAR_RS15845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPAR_RS15875	COG0297	glycogen (starch) synthase activity
VAPAR_RS15880	COG2197	response regulator
VAPAR_RS15905	COG0587	DNA-directed DNA polymerase activity
VAPAR_RS15940	COG0129	dihydroxy-acid dehydratase activity
VAPAR_RS15950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAPAR_RS15980	COG3384	dioxygenase
VAPAR_RS15990	COG2197	response regulator
VAPAR_RS16000	COG1132	(ABC) transporter
VAPAR_RS16010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VAPAR_RS16020	COG1272	protein, Hemolysin III
VAPAR_RS16030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAPAR_RS16040	COG0640	Transcriptional regulator
VAPAR_RS16050	COG1183	phosphatidylcholine synthase activity
VAPAR_RS16105	COG2818	Glycosylase
VAPAR_RS16120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAPAR_RS16125	COG0583	DNA-binding transcription factor activity
VAPAR_RS16130	COG0583	DNA-binding transcription factor activity
VAPAR_RS16145	COG1024	Enoyl-CoA hydratase
VAPAR_RS16175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS16195	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS16205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VAPAR_RS16210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS16235	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VAPAR_RS16240	COG0545	Peptidyl-prolyl cis-trans isomerase
VAPAR_RS16245	COG0531	amino acid
VAPAR_RS16250	COG4303	Ethanolamine ammonia lyase large subunit
VAPAR_RS16255	COG4302	ethanolamine ammonia-lyase activity
VAPAR_RS16285	COG0671	phosphoesterase, PA-phosphatase related
VAPAR_RS16295	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS16300	COG0642	Histidine kinase
VAPAR_RS16305	COG0824	Thioesterase
VAPAR_RS16310	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS16325	COG2814	Major facilitator Superfamily
VAPAR_RS16330	COG4336	lyase activity
VAPAR_RS16335	COG0583	DNA-binding transcription factor activity
VAPAR_RS16340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPAR_RS16345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPAR_RS16355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPAR_RS16355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPAR_RS16365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VAPAR_RS16370	COG0509	glycine decarboxylation via glycine cleavage system
VAPAR_RS16375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAPAR_RS16375	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAPAR_RS16405	COG0583	DNA-binding transcription factor activity
VAPAR_RS16410	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS16415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPAR_RS16425	COG3959	Transketolase, thiamine diphosphate binding domain
VAPAR_RS16430	COG3958	Transketolase
VAPAR_RS16435	COG2084	Dehydrogenase
VAPAR_RS16440	COG3148	PFAM DTW domain containing protein
VAPAR_RS16465	COG0477	Major facilitator Superfamily
VAPAR_RS16470	COG3185	4-Hydroxyphenylpyruvate dioxygenase
VAPAR_RS16470	COG1082	Xylose isomerase domain protein TIM barrel
VAPAR_RS16480	COG2814	Major facilitator Superfamily
VAPAR_RS16490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAPAR_RS16495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAPAR_RS16500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAPAR_RS16505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAPAR_RS16510	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAPAR_RS16515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAPAR_RS16520	COG1414	Transcriptional regulator
VAPAR_RS16530	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS16535	COG0642	Histidine kinase
VAPAR_RS16555	COG2084	Dehydrogenase
VAPAR_RS16560	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS16565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAPAR_RS16570	COG1063	alcohol dehydrogenase
VAPAR_RS16575	COG1609	Transcriptional regulator
VAPAR_RS16580	COG3386	PFAM SMP-30 Gluconolaconase
VAPAR_RS16585	COG1129	ABC transporter
VAPAR_RS16615	COG1175	transmembrane transport
VAPAR_RS16660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VAPAR_RS16675	COG0640	Transcriptional regulator
VAPAR_RS16695	COG1294	oxidase, subunit
VAPAR_RS16700	COG1271	oxidase subunit
VAPAR_RS16705	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VAPAR_RS16710	COG4988	ABC transporter
VAPAR_RS16725	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS16740	COG3264	Mechanosensitive ion channel
VAPAR_RS16740	COG1511	domain protein
VAPAR_RS16750	COG0714	Associated with various cellular activities
VAPAR_RS16765	COG2951	lytic endotransglycosylase activity
VAPAR_RS16795	COG1131	(ABC) transporter
VAPAR_RS16830	COG0395	ABC-type sugar transport system, permease component
VAPAR_RS16840	COG3842	ATPase activity
VAPAR_RS16845	COG3842	ATPase activity
VAPAR_RS16860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VAPAR_RS16870	COG2194	sulfuric ester hydrolase activity
VAPAR_RS16880	COG2308	Evidence 4 Homologs of previously reported genes of
VAPAR_RS16900	COG1305	Transglutaminase-like
VAPAR_RS16915	COG2271	Major facilitator Superfamily
VAPAR_RS16925	COG1609	Transcriptional regulator
VAPAR_RS16935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAPAR_RS16945	COG1126	abc transporter atp-binding protein
VAPAR_RS16950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPAR_RS16955	COG0765	amino acid transport
VAPAR_RS16960	COG0765	amino acid transport
VAPAR_RS16970	COG1335	isochorismatase
VAPAR_RS17000	COG0739	heme binding
VAPAR_RS17000	COG1196	nuclear chromosome segregation
VAPAR_RS17000	COG0741	lytic transglycosylase activity
VAPAR_RS17020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPAR_RS17025	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VAPAR_RS17030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VAPAR_RS17045	COG2850	peptidyl-arginine hydroxylation
VAPAR_RS17050	COG1047	Peptidyl-prolyl cis-trans
VAPAR_RS17060	COG0756	dUTP diphosphatase activity
VAPAR_RS17070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VAPAR_RS17075	COG0504	CTP synthase activity
VAPAR_RS17080	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAPAR_RS17090	COG0148	phosphopyruvate hydratase activity
VAPAR_RS17095	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VAPAR_RS17100	COG3201	nicotinamide mononucleotide transporter
VAPAR_RS17115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VAPAR_RS17125	COG2833	Protein of unknown function (DUF455)
VAPAR_RS17135	COG0183	Belongs to the thiolase family
VAPAR_RS17145	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS17150	COG4974	Belongs to the 'phage' integrase family
VAPAR_RS17155	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS17165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VAPAR_RS17170	COG0802	atpase or kinase
VAPAR_RS17175	COG0860	N-Acetylmuramoyl-L-alanine amidase
VAPAR_RS17185	COG0586	Pfam SNARE associated Golgi protein
VAPAR_RS17190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VAPAR_RS17200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VAPAR_RS17205	COG0577	efflux transmembrane transporter activity
VAPAR_RS17205	COG1136	(ABC) transporter
VAPAR_RS17220	COG5285	phytanoyl-CoA dioxygenase
VAPAR_RS17230	COG3795	YCII-related domain
VAPAR_RS17235	COG4941	Belongs to the sigma-70 factor family
VAPAR_RS17255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VAPAR_RS17280	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS17295	COG0411	ABC transporter
VAPAR_RS17310	COG1566	PFAM secretion protein HlyD family protein
VAPAR_RS17320	COG1846	Transcriptional regulator
VAPAR_RS17325	COG1132	(ABC) transporter
VAPAR_RS17335	COG0494	nUDIX hydrolase
VAPAR_RS17345	COG1007	ATP synthesis coupled electron transport
VAPAR_RS17360	COG0713	ATP synthesis coupled electron transport
VAPAR_RS17370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPAR_RS17375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VAPAR_RS17380	COG1034	ATP synthesis coupled electron transport
VAPAR_RS17395	COG0649	NAD binding
VAPAR_RS17400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPAR_RS17405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPAR_RS17410	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAPAR_RS17425	COG0149	triose-phosphate isomerase activity
VAPAR_RS17435	COG1185	polyribonucleotide nucleotidyltransferase activity
VAPAR_RS17440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VAPAR_RS17445	COG0436	Aminotransferase
VAPAR_RS17450	COG0683	leucine binding
VAPAR_RS17465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VAPAR_RS17470	COG3707	response regulator
VAPAR_RS17475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS17480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS17485	COG1116	anion transmembrane transporter activity
VAPAR_RS17495	COG2223	nitrite transmembrane transporter activity
VAPAR_RS17500	COG2815	serine threonine protein kinase
VAPAR_RS17500	COG0515	serine threonine protein kinase
VAPAR_RS17505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAPAR_RS17515	COG0243	molybdopterin cofactor binding
VAPAR_RS17520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAPAR_RS17530	COG3842	ATPase activity
VAPAR_RS17540	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPAR_RS17545	COG3833	ABC-type maltose transport systems, permease component
VAPAR_RS17555	COG0791	NLP P60 protein
VAPAR_RS17560	COG2081	HI0933 family
VAPAR_RS17565	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VAPAR_RS17570	COG1610	YqeY-like protein
VAPAR_RS17575	COG0494	nUDIX hydrolase
VAPAR_RS17610	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VAPAR_RS17610	COG1672	PFAM Archaeal ATPase
VAPAR_RS17625	COG0312	modulator of DNA gyrase
VAPAR_RS17635	COG0521	Mo-molybdopterin cofactor biosynthetic process
VAPAR_RS17665	COG0642	Histidine kinase
VAPAR_RS17670	COG0475	glutathione-regulated potassium exporter activity
VAPAR_RS17680	COG0789	Transcriptional regulator
VAPAR_RS17685	COG1045	serine acetyltransferase
VAPAR_RS17695	COG0483	inositol monophosphate 1-phosphatase activity
VAPAR_RS17700	COG1289	transmembrane transporter activity
VAPAR_RS17710	COG1522	sequence-specific DNA binding
VAPAR_RS17720	COG2311	Membrane
VAPAR_RS17725	COG0583	DNA-binding transcription factor activity
VAPAR_RS17735	COG1846	Transcriptional regulator
VAPAR_RS17750	COG3119	arylsulfatase activity
VAPAR_RS17775	COG1858	cytochrome C peroxidase
VAPAR_RS17795	COG2375	cellular response to nickel ion
VAPAR_RS17800	COG0598	Magnesium transport protein CorA
VAPAR_RS17810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VAPAR_RS17825	COG2197	response regulator
VAPAR_RS17835	COG4585	Histidine kinase
VAPAR_RS17860	COG1968	undecaprenyl-diphosphatase activity
VAPAR_RS17870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPAR_RS17875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAPAR_RS17880	COG1737	Transcriptional regulator
VAPAR_RS17895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPAR_RS17900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPAR_RS17905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPAR_RS17925	COG2972	Histidine kinase
VAPAR_RS17940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAPAR_RS17965	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAPAR_RS17970	COG0004	ammonium transporteR
VAPAR_RS17975	COG3279	Response regulator of the LytR AlgR family
VAPAR_RS18010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VAPAR_RS18020	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VAPAR_RS18020	COG0517	IMP dehydrogenase activity
VAPAR_RS18030	COG0789	Transcriptional regulator
VAPAR_RS18040	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS18050	COG2918	glutathione biosynthetic process
VAPAR_RS18060	COG0400	carboxylic ester hydrolase activity
VAPAR_RS18105	COG2354	Protein conserved in bacteria
VAPAR_RS18115	COG4628	conserved protein (DUF2132)
VAPAR_RS18130	COG0564	pseudouridine synthase activity
VAPAR_RS18150	COG3415	Transposase
VAPAR_RS18150	COG2801	Transposase and inactivated derivatives
VAPAR_RS18155	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
VAPAR_RS18160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAPAR_RS18165	COG1252	NADH dehydrogenase
VAPAR_RS18170	COG1525	nuclease
VAPAR_RS18175	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS18180	COG1764	response to oxidative stress
VAPAR_RS18200	COG0765	amino acid transport
VAPAR_RS18205	COG0765	amino acid transport
VAPAR_RS18225	COG0584	glycerophosphoryl diester phosphodiesterase
VAPAR_RS18245	COG3191	aminopeptidase activity
VAPAR_RS18260	COG0488	(ABC) transporter
VAPAR_RS18265	COG0513	Belongs to the DEAD box helicase family
VAPAR_RS18275	COG3842	ATPase activity
VAPAR_RS18285	COG1175	transmembrane transport
VAPAR_RS18295	COG2186	Transcriptional regulator
VAPAR_RS18300	COG0129	dihydroxy-acid dehydratase activity
VAPAR_RS18310	COG0800	Aldolase
VAPAR_RS18350	COG1840	ABC-type Fe3 transport system, periplasmic component
VAPAR_RS18360	COG3842	ATPase activity
VAPAR_RS18370	COG0346	lactoylglutathione lyase activity
VAPAR_RS18380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAPAR_RS18390	COG0800	Aldolase
VAPAR_RS18415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAPAR_RS18420	COG0259	pyridoxamine-phosphate oxidase activity
VAPAR_RS18435	COG0679	Auxin Efflux Carrier
VAPAR_RS18450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAPAR_RS18455	COG1309	transcriptional regulator
VAPAR_RS18460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAPAR_RS18485	COG2169	Transcriptional regulator
VAPAR_RS18495	COG0697	spore germination
VAPAR_RS18515	COG0625	glutathione transferase activity
VAPAR_RS18560	COG4774	siderophore transport
VAPAR_RS18630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPAR_RS18655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAPAR_RS18680	COG0285	dihydrofolate synthase activity
VAPAR_RS18685	COG1393	Belongs to the ArsC family
VAPAR_RS18695	COG3123	guanosine phosphorylase activity
VAPAR_RS18700	COG0137	argininosuccinate synthase activity
VAPAR_RS18710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VAPAR_RS18715	COG1666	GTP binding
VAPAR_RS18725	COG0251	oxidation-reduction process
VAPAR_RS18730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VAPAR_RS18735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VAPAR_RS18740	COG0667	Aldo Keto reductase
VAPAR_RS18745	COG2267	carboxylic ester hydrolase activity
VAPAR_RS18795	COG1464	Belongs to the NlpA lipoprotein family
VAPAR_RS18800	COG2011	ABC-type metal ion transport system permease component
VAPAR_RS18810	COG1464	Belongs to the NlpA lipoprotein family
VAPAR_RS18820	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAPAR_RS18825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAPAR_RS18830	COG0308	aminopeptidase N
VAPAR_RS18840	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VAPAR_RS18890	COG0582	viral genome integration into host DNA
VAPAR_RS18920	COG2080	2 iron, 2 sulfur cluster binding
VAPAR_RS18925	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
VAPAR_RS18930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPAR_RS18935	COG3302	dmso reductase anchor subunit
VAPAR_RS18940	COG0437	4 iron, 4 sulfur cluster binding
VAPAR_RS18945	COG0243	molybdopterin cofactor binding
VAPAR_RS18950	COG0583	DNA-binding transcription factor activity
VAPAR_RS18960	COG2721	sulfolactate sulfo-lyase activity
VAPAR_RS18965	COG2721	sulfolactate sulfo-lyase activity
VAPAR_RS18970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPAR_RS18975	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VAPAR_RS18990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAPAR_RS19000	COG1414	Transcriptional regulator
VAPAR_RS19025	COG1012	belongs to the aldehyde dehydrogenase family
VAPAR_RS19030	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS19045	COG1414	Transcriptional regulator
VAPAR_RS19060	COG2771	luxR family
VAPAR_RS19080	COG2010	Cytochrome c
VAPAR_RS19080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPAR_RS19085	COG0583	DNA-binding transcription factor activity
VAPAR_RS19090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS19095	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
VAPAR_RS19100	COG4521	taurine ABC transporter
VAPAR_RS19105	COG2801	Transposase and inactivated derivatives
VAPAR_RS19105	COG3415	Transposase
VAPAR_RS19110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPAR_RS19145	COG1253	flavin adenine dinucleotide binding
VAPAR_RS19150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VAPAR_RS19195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS19205	COG1116	anion transmembrane transporter activity
VAPAR_RS19210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS19215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS19225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPAR_RS19235	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS19240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS19260	COG0513	Belongs to the DEAD box helicase family
VAPAR_RS19265	COG2321	neutral zinc metallopeptidase
VAPAR_RS19270	COG0717	Belongs to the dCTP deaminase family
VAPAR_RS19275	COG0402	S-adenosylhomocysteine deaminase activity
VAPAR_RS19285	COG2366	antibiotic biosynthetic process
VAPAR_RS19290	COG4977	sequence-specific DNA binding
VAPAR_RS19295	COG0583	DNA-binding transcription factor activity
VAPAR_RS19300	COG2814	Major facilitator Superfamily
VAPAR_RS19305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAPAR_RS19310	COG4654	Cytochrome c, class I
VAPAR_RS19320	COG0604	alcohol dehydrogenase
VAPAR_RS19355	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS19365	COG0583	DNA-binding transcription factor activity
VAPAR_RS19380	COG4603	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS19385	COG3845	ABC transporter
VAPAR_RS19390	COG2252	PERMEase
VAPAR_RS19400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VAPAR_RS19465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
VAPAR_RS19495	COG2351	hydroxyisourate hydrolase activity
VAPAR_RS19500	COG2186	Transcriptional regulator
VAPAR_RS19515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAPAR_RS19530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPAR_RS19545	COG1953	Uracil, thiamine, allantoin
VAPAR_RS19560	COG1309	transcriptional regulator
VAPAR_RS19575	COG2233	PERMEase
VAPAR_RS19580	COG0656	L-ascorbic acid biosynthetic process
VAPAR_RS19590	COG4566	intracellular signal transduction
VAPAR_RS19595	COG0477	Major facilitator Superfamily
VAPAR_RS19610	COG1301	dicarboxylic acid transport
VAPAR_RS19620	COG0628	permease
VAPAR_RS19635	COG0583	DNA-binding transcription factor activity
VAPAR_RS19640	COG3960	tartronate-semialdehyde synthase activity
VAPAR_RS19645	COG3622	Belongs to the hyi family
VAPAR_RS19650	COG2084	Dehydrogenase
VAPAR_RS19660	COG0280	phosphate acetyltransferase
VAPAR_RS19660	COG0281	malic enzyme
VAPAR_RS19670	COG1116	anion transmembrane transporter activity
VAPAR_RS19675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS19705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPAR_RS19715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VAPAR_RS19725	COG0829	nickel cation binding
VAPAR_RS19730	COG0583	DNA-binding transcription factor activity
VAPAR_RS19775	COG2879	small protein
VAPAR_RS19780	COG1966	Carbon starvation protein
VAPAR_RS19790	COG0791	NLP P60 protein
VAPAR_RS19850	COG0667	Aldo Keto reductase
VAPAR_RS19855	COG3540	Alkaline phosphatase
VAPAR_RS19860	COG0584	glycerophosphoryl diester phosphodiesterase
VAPAR_RS19865	COG0395	ABC-type sugar transport system, permease component
VAPAR_RS19870	COG1175	transmembrane transport
VAPAR_RS19885	COG2390	Transcriptional regulator
VAPAR_RS19895	COG1595	DNA-templated transcription, initiation
VAPAR_RS19905	COG2814	Major facilitator Superfamily
VAPAR_RS19945	COG0477	Major facilitator Superfamily
VAPAR_RS19975	COG0613	PHP domain protein
VAPAR_RS19985	COG0009	L-threonylcarbamoyladenylate synthase
VAPAR_RS19990	COG1994	Peptidase M50
VAPAR_RS19995	COG0180	Tryptophanyl-tRNA synthetase
VAPAR_RS20000	COG2197	response regulator
VAPAR_RS20015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VAPAR_RS20025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VAPAR_RS20030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VAPAR_RS20035	COG1047	Peptidyl-prolyl cis-trans
VAPAR_RS20040	COG2003	Belongs to the UPF0758 family
VAPAR_RS20060	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAPAR_RS20070	COG0765	amino acid transport
VAPAR_RS20075	COG0765	amino acid transport
VAPAR_RS20085	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
VAPAR_RS20095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAPAR_RS20100	COG0477	Major facilitator Superfamily
VAPAR_RS20105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VAPAR_RS20110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPAR_RS20115	COG1845	cytochrome c oxidase, subunit III
VAPAR_RS20120	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VAPAR_RS20135	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
VAPAR_RS20140	COG1272	protein, Hemolysin III
VAPAR_RS20145	COG2900	Belongs to the SlyX family
VAPAR_RS20155	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VAPAR_RS20160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAPAR_RS20180	COG0437	4 iron, 4 sulfur cluster binding
VAPAR_RS20185	COG3383	formate dehydrogenase (NAD+) activity
VAPAR_RS20185	COG0243	molybdopterin cofactor binding
VAPAR_RS20200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VAPAR_RS20220	COG0725	ABC transporter, periplasmic molybdate-binding protein
VAPAR_RS20225	COG4149	molybdate abc transporter
VAPAR_RS20235	COG3383	formate dehydrogenase (NAD+) activity
VAPAR_RS20245	COG0583	DNA-binding transcription factor activity
VAPAR_RS20250	COG0489	protein tyrosine kinase activity
VAPAR_RS20260	COG3132	Protein of unknown function, DUF480
VAPAR_RS20265	COG3698	Phosphodiester glycosidase
VAPAR_RS20270	COG0473	3-isopropylmalate dehydrogenase activity
VAPAR_RS20275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAPAR_RS20280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAPAR_RS20280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAPAR_RS20315	COG0659	secondary active sulfate transmembrane transporter activity
VAPAR_RS20335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VAPAR_RS20340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VAPAR_RS20345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VAPAR_RS20350	COG0602	queuosine metabolic process
VAPAR_RS20360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VAPAR_RS20370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAPAR_RS20375	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VAPAR_RS20385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAPAR_RS20390	COG0588	phosphoglycerate mutase activity
VAPAR_RS20395	COG0793	Belongs to the peptidase S41A family
VAPAR_RS20400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VAPAR_RS20405	COG2982	Protein involved in outer membrane biogenesis
VAPAR_RS20415	COG2197	response regulator
VAPAR_RS20450	COG2823	Periplasmic or secreted lipoprotein
VAPAR_RS20475	COG3568	Endonuclease Exonuclease Phosphatase
VAPAR_RS20480	COG0494	nUDIX hydrolase
VAPAR_RS20485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VAPAR_RS20500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAPAR_RS20505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VAPAR_RS20520	COG2226	methyltransferase
VAPAR_RS20540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPAR_RS20550	COG1175	transmembrane transport
VAPAR_RS20555	COG0395	ABC-type sugar transport system, permease component
VAPAR_RS20560	COG3842	ATPase activity
VAPAR_RS20565	COG0584	glycerophosphoryl diester phosphodiesterase
VAPAR_RS20570	COG3264	Mechanosensitive ion channel
VAPAR_RS20570	COG1511	domain protein
VAPAR_RS20625	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VAPAR_RS20640	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VAPAR_RS20645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAPAR_RS20650	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAPAR_RS20700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VAPAR_RS20710	COG1677	Flagellar hook-basal body complex protein FliE
VAPAR_RS20725	COG1317	bacterial-type flagellum organization
VAPAR_RS20735	COG2882	bacterial-type flagellum organization
VAPAR_RS20745	COG1580	Controls the rotational direction of flagella during chemotaxis
VAPAR_RS20765	COG1338	Plays a role in the flagellum-specific transport system
VAPAR_RS20785	COG1256	bacterial-type flagellum assembly
VAPAR_RS20795	COG0840	transmembrane signaling receptor activity
VAPAR_RS20800	COG0840	transmembrane signaling receptor activity
VAPAR_RS20810	COG0835	chemotaxis
VAPAR_RS20815	COG0840	transmembrane signaling receptor activity
VAPAR_RS20825	COG0835	chemotaxis
VAPAR_RS20835	COG1706	bacterial-type flagellum-dependent cell motility
VAPAR_RS20840	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VAPAR_RS20850	COG4787	bacterial-type flagellum-dependent cell motility
VAPAR_RS20860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VAPAR_RS20865	COG1558	bacterial-type flagellum-dependent cell motility
VAPAR_RS20870	COG1815	bacterial-type flagellum-dependent cell motility
VAPAR_RS20900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VAPAR_RS20905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VAPAR_RS20910	COG2890	protein-(glutamine-N5) methyltransferase activity
VAPAR_RS20915	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VAPAR_RS20925	COG1253	flavin adenine dinucleotide binding
VAPAR_RS20930	COG0741	lytic transglycosylase activity
VAPAR_RS20935	COG0442	prolyl-tRNA aminoacylation
VAPAR_RS20940	COG0494	nUDIX hydrolase
VAPAR_RS20950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VAPAR_RS20955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VAPAR_RS20960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VAPAR_RS20965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VAPAR_RS20970	COG0142	geranyltranstransferase activity
VAPAR_RS20990	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VAPAR_RS21000	COG1696	Membrane protein involved in D-alanine export
VAPAR_RS21010	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VAPAR_RS21015	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VAPAR_RS21020	COG2755	lipolytic protein G-D-S-L family
VAPAR_RS21020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VAPAR_RS21025	COG0494	nUDIX hydrolase
VAPAR_RS21035	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
VAPAR_RS21040	COG0653	protein targeting
VAPAR_RS21055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VAPAR_RS21060	COG0583	DNA-binding transcription factor activity
VAPAR_RS21080	COG0831	urea catabolic process
VAPAR_RS21090	COG0832	Belongs to the urease beta subunit family
VAPAR_RS21095	COG0804	urea catabolic process
VAPAR_RS21110	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
VAPAR_RS21115	COG0830	nickel cation binding
VAPAR_RS21120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VAPAR_RS21150	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS21165	COG2205	protein histidine kinase activity
VAPAR_RS21170	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS21180	COG2982	Protein involved in outer membrane biogenesis
VAPAR_RS21230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS21240	COG0583	DNA-binding transcription factor activity
VAPAR_RS21245	COG2186	Transcriptional regulator
VAPAR_RS21270	COG2271	Major facilitator Superfamily
VAPAR_RS21275	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS21285	COG0596	Alpha beta hydrolase
VAPAR_RS21330	COG2309	aminopeptidase activity
VAPAR_RS21335	COG1335	isochorismatase
VAPAR_RS21345	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS21365	COG2223	nitrite transmembrane transporter activity
VAPAR_RS21370	COG0583	DNA-binding transcription factor activity
VAPAR_RS21380	COG0837	glucose binding
VAPAR_RS21380	COG1737	Transcriptional regulator
VAPAR_RS21395	COG1024	Enoyl-CoA hydratase
VAPAR_RS21400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS21410	COG0183	Belongs to the thiolase family
VAPAR_RS21430	COG2207	Transcriptional regulator
VAPAR_RS21435	COG1484	DNA-dependent DNA replication
VAPAR_RS21445	COG1289	transmembrane transporter activity
VAPAR_RS21465	COG0583	DNA-binding transcription factor activity
VAPAR_RS21480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAPAR_RS21485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VAPAR_RS21505	COG1561	YicC-like family, N-terminal region
VAPAR_RS21510	COG0194	GDP metabolic process
VAPAR_RS21515	COG1758	RNA polymerase activity
VAPAR_RS21520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAPAR_RS21535	COG0529	Catalyzes the synthesis of activated sulfate
VAPAR_RS21550	COG1420	regulation of RNA biosynthetic process
VAPAR_RS21555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VAPAR_RS21560	COG0497	DNA recombination
VAPAR_RS21565	COG1660	Displays ATPase and GTPase activities
VAPAR_RS21575	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
VAPAR_RS21580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAPAR_RS21595	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VAPAR_RS21605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VAPAR_RS21610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VAPAR_RS21615	COG0193	aminoacyl-tRNA hydrolase activity
VAPAR_RS21625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAPAR_RS21635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPAR_RS21645	COG4608	Belongs to the ABC transporter superfamily
VAPAR_RS21650	COG0747	negative chemotaxis
VAPAR_RS21660	COG0154	amidase activity
VAPAR_RS21670	COG0583	DNA-binding transcription factor activity
VAPAR_RS21685	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VAPAR_RS21695	COG2267	carboxylic ester hydrolase activity
VAPAR_RS21700	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VAPAR_RS21705	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VAPAR_RS21710	COG1984	allophanate hydrolase subunit 2
VAPAR_RS21715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VAPAR_RS21720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VAPAR_RS21725	COG0742	ribosomal rna small subunit methyltransferase
VAPAR_RS21740	COG0612	Peptidase, M16
VAPAR_RS21745	COG0612	Peptidase, M16
VAPAR_RS21765	COG2197	response regulator
VAPAR_RS21775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAPAR_RS21780	COG4335	DNA alkylation repair
VAPAR_RS21785	COG1999	signal sequence binding
VAPAR_RS21790	COG0109	protoheme IX farnesyltransferase activity
VAPAR_RS21825	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VAPAR_RS21830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPAR_RS21845	COG2226	methyltransferase
VAPAR_RS21850	COG1040	competence protein
VAPAR_RS21855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VAPAR_RS21865	COG0489	protein tyrosine kinase activity
VAPAR_RS21885	COG1024	Enoyl-CoA hydratase
VAPAR_RS21890	COG3320	Male sterility
VAPAR_RS21890	COG1022	Amp-dependent synthetase and ligase
VAPAR_RS21905	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS21920	COG2764	glyoxalase bleomycin resistance protein dioxygenase
VAPAR_RS21940	COG5507	3-demethylubiquinone-9 3-methyltransferase
VAPAR_RS21960	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
VAPAR_RS21965	COG0430	RNA-3'-phosphate cyclase activity
VAPAR_RS21975	COG1690	Belongs to the RtcB family
VAPAR_RS21980	COG0275	rRNA processing
VAPAR_RS21985	COG4650	regulator
VAPAR_RS21990	COG2423	ornithine cyclodeaminase activity
VAPAR_RS22010	COG1764	response to oxidative stress
VAPAR_RS22035	COG0183	Belongs to the thiolase family
VAPAR_RS22040	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
VAPAR_RS22050	COG1414	Transcriptional regulator
VAPAR_RS22070	COG3063	Type IV pilus biogenesis stability protein PilW
VAPAR_RS22095	COG4964	Belongs to the GSP D family
VAPAR_RS22145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPAR_RS22150	COG2274	protein secretion by the type I secretion system
VAPAR_RS22160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAPAR_RS22180	COG0583	DNA-binding transcription factor activity
VAPAR_RS22185	COG3485	protocatechuate 3,4-dioxygenase
VAPAR_RS22190	COG3485	protocatechuate 3,4-dioxygenase
VAPAR_RS22200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAPAR_RS22230	COG0583	DNA-binding transcription factor activity
VAPAR_RS22250	COG0469	pyruvate kinase activity
VAPAR_RS22255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPAR_RS22265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VAPAR_RS22270	COG0045	succinate-CoA ligase (ADP-forming) activity
VAPAR_RS22280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS22285	COG4191	Histidine kinase
VAPAR_RS22335	COG0582	viral genome integration into host DNA
VAPAR_RS22365	COG0517	IMP dehydrogenase activity
VAPAR_RS22370	COG4974	Belongs to the 'phage' integrase family
VAPAR_RS22455	COG2831	hemolysin activation secretion protein
VAPAR_RS22465	COG3210	domain, Protein
VAPAR_RS22525	COG0587	DNA-directed DNA polymerase activity
VAPAR_RS22630	COG0537	adenosine 5'-monophosphoramidase activity
VAPAR_RS22640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VAPAR_RS22645	COG1074	ATP-dependent DNA helicase activity
VAPAR_RS22650	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VAPAR_RS22665	COG2733	membrane
VAPAR_RS22685	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VAPAR_RS22700	COG0420	3'-5' exonuclease activity
VAPAR_RS22725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VAPAR_RS22795	COG2274	protein secretion by the type I secretion system
VAPAR_RS22815	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS22825	COG2205	protein histidine kinase activity
VAPAR_RS22835	COG2207	Transcriptional regulator
VAPAR_RS22860	COG0540	Belongs to the ATCase OTCase family
VAPAR_RS22865	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VAPAR_RS22870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VAPAR_RS22875	COG1678	Uncharacterized ACR, COG1678
VAPAR_RS22880	COG0415	Belongs to the DNA photolyase family
VAPAR_RS22900	COG2198	Histidine kinase
VAPAR_RS22900	COG0784	Response regulator, receiver
VAPAR_RS22900	COG0643	Histidine kinase
VAPAR_RS22905	COG0840	transmembrane signaling receptor activity
VAPAR_RS22930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VAPAR_RS22935	COG0138	bifunctional purine biosynthesis protein purh
VAPAR_RS22950	COG1238	metal cluster binding
VAPAR_RS22960	COG0012	GTP binding
VAPAR_RS22965	COG1879	ABC-type sugar transport system periplasmic component
VAPAR_RS22970	COG1129	ABC transporter
VAPAR_RS22975	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS22980	COG1609	Transcriptional regulator
VAPAR_RS22985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAPAR_RS22990	COG1869	D-ribose catabolic process
VAPAR_RS23000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPAR_RS23015	COG1024	Enoyl-CoA hydratase
VAPAR_RS23040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPAR_RS23050	COG2863	cytochrome
VAPAR_RS23065	COG1230	cation diffusion facilitator family transporter
VAPAR_RS23070	COG2255	four-way junction helicase activity
VAPAR_RS23075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VAPAR_RS23080	COG2267	carboxylic ester hydrolase activity
VAPAR_RS23085	COG2453	phosphatase
VAPAR_RS23085	COG0671	phosphoesterase, PA-phosphatase related
VAPAR_RS23100	COG4589	Belongs to the CDS family
VAPAR_RS23110	COG0632	four-way junction helicase activity
VAPAR_RS23115	COG1702	phosphate starvation-inducible protein PhoH
VAPAR_RS23120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VAPAR_RS23125	COG1490	D-aminoacyl-tRNA deacylase activity
VAPAR_RS23130	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VAPAR_RS23145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAPAR_RS23150	COG0739	heme binding
VAPAR_RS23155	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VAPAR_RS23160	COG2814	Major facilitator Superfamily
VAPAR_RS23165	COG0316	Belongs to the HesB IscA family
VAPAR_RS23170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VAPAR_RS23175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VAPAR_RS23180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VAPAR_RS23185	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAPAR_RS23200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VAPAR_RS23215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VAPAR_RS23250	COG2423	ornithine cyclodeaminase activity
VAPAR_RS23260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VAPAR_RS23265	COG3842	ATPase activity
VAPAR_RS23275	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAPAR_RS23280	COG1177	transmembrane transport
VAPAR_RS23290	COG1012	belongs to the aldehyde dehydrogenase family
VAPAR_RS23295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAPAR_RS23310	COG0477	Major facilitator Superfamily
VAPAR_RS23335	COG1254	Belongs to the acylphosphatase family
VAPAR_RS23345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS23360	COG1414	Transcriptional regulator
VAPAR_RS23365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPAR_RS23385	COG1024	Enoyl-CoA hydratase
VAPAR_RS23390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAPAR_RS23395	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS23400	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS23415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAPAR_RS23420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VAPAR_RS23425	COG3012	SEC-C Motif Domain Protein
VAPAR_RS23430	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS23440	COG0183	Belongs to the thiolase family
VAPAR_RS23445	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
VAPAR_RS23450	COG0288	reversible hydration of carbon dioxide
VAPAR_RS23455	COG0789	Transcriptional regulator
VAPAR_RS23490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAPAR_RS23495	COG0751	glycine-tRNA ligase activity
VAPAR_RS23500	COG0752	glycyl-tRNA synthetase alpha subunit
VAPAR_RS23505	COG1597	lipid kinase activity
VAPAR_RS23510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VAPAR_RS23515	COG0671	phosphoesterase, PA-phosphatase related
VAPAR_RS23540	COG0583	DNA-binding transcription factor activity
VAPAR_RS23545	COG2814	Major facilitator Superfamily
VAPAR_RS23580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS23590	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VAPAR_RS23595	COG4535	Mg2 and Co2 transporter CorC
VAPAR_RS23605	COG1522	sequence-specific DNA binding
VAPAR_RS23620	COG3186	Phenylalanine-4-hydroxylase
VAPAR_RS23625	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS23685	COG0488	(ABC) transporter
VAPAR_RS23690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAPAR_RS23735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPAR_RS23770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAPAR_RS23790	COG0439	Biotin carboxylase
VAPAR_RS23795	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS23810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAPAR_RS23810	COG2124	cytochrome p450
VAPAR_RS23820	COG1309	transcriptional regulator
VAPAR_RS23840	COG1505	serine-type exopeptidase activity
VAPAR_RS23845	COG0010	Belongs to the arginase family
VAPAR_RS23870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VAPAR_RS23905	COG2084	Dehydrogenase
VAPAR_RS23915	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAPAR_RS23920	COG0792	nuclease activity
VAPAR_RS23925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAPAR_RS23940	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS23950	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS23960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VAPAR_RS23965	COG0583	DNA-binding transcription factor activity
VAPAR_RS23990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAPAR_RS23995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAPAR_RS24015	COG0429	hydrolase of the alpha beta-hydrolase fold
VAPAR_RS24025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VAPAR_RS24030	COG1335	isochorismatase
VAPAR_RS24035	COG0251	oxidation-reduction process
VAPAR_RS24040	COG2267	carboxylic ester hydrolase activity
VAPAR_RS24045	COG0778	Nitroreductase
VAPAR_RS24050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VAPAR_RS24055	COG1309	transcriptional regulator
VAPAR_RS24075	COG3845	ABC transporter
VAPAR_RS24085	COG1079	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS24120	COG3118	belongs to the thioredoxin family
VAPAR_RS24125	COG1201	RNA secondary structure unwinding
VAPAR_RS24130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAPAR_RS24130	COG1793	dna ligase
VAPAR_RS24135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAPAR_RS24135	COG1793	dna ligase
VAPAR_RS24150	COG0673	inositol 2-dehydrogenase activity
VAPAR_RS24155	COG1879	ABC-type sugar transport system periplasmic component
VAPAR_RS24160	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS24175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VAPAR_RS24180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VAPAR_RS24190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VAPAR_RS24195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VAPAR_RS24200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VAPAR_RS24205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VAPAR_RS24215	COG0356	it plays a direct role in the translocation of protons across the membrane
VAPAR_RS24225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAPAR_RS24230	COG2921	Belongs to the UPF0250 family
VAPAR_RS24235	COG0321	lipoyl(octanoyl) transferase activity
VAPAR_RS24240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VAPAR_RS24250	COG0583	DNA-binding transcription factor activity
VAPAR_RS24255	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS24260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VAPAR_RS24280	COG2130	NADP-dependent
VAPAR_RS24290	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS24315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VAPAR_RS24320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAPAR_RS24330	COG2814	Major facilitator Superfamily
VAPAR_RS24340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAPAR_RS24345	COG0456	acetyltransferase
VAPAR_RS24350	COG0678	peroxiredoxin activity
VAPAR_RS24355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VAPAR_RS24360	COG0255	Belongs to the universal ribosomal protein uL29 family
VAPAR_RS24365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VAPAR_RS24370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VAPAR_RS24375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VAPAR_RS24380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VAPAR_RS24385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VAPAR_RS24390	COG0089	rRNA binding
VAPAR_RS24395	COG0088	Forms part of the polypeptide exit tunnel
VAPAR_RS24400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VAPAR_RS24415	COG0051	transcription antitermination factor activity, RNA binding
VAPAR_RS24420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAPAR_RS24425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAPAR_RS24430	COG0049	tRNA binding
VAPAR_RS24435	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VAPAR_RS24440	COG1686	Belongs to the peptidase S11 family
VAPAR_RS24445	COG2945	thiolester hydrolase activity
VAPAR_RS24460	COG1981	membrane
VAPAR_RS24470	COG0598	Magnesium transport protein CorA
VAPAR_RS24480	COG0583	DNA-binding transcription factor activity
VAPAR_RS24485	COG0412	Dienelactone hydrolase
VAPAR_RS24495	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS24500	COG2095	MarC family integral membrane protein
VAPAR_RS24535	COG0559	Belongs to the binding-protein-dependent transport system permease family
VAPAR_RS24550	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VAPAR_RS24555	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAPAR_RS24570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
VAPAR_RS24575	COG1652	LysM domain
VAPAR_RS24585	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAPAR_RS24600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VAPAR_RS24600	COG0574	Belongs to the PEP-utilizing enzyme family
VAPAR_RS24615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAPAR_RS24620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAPAR_RS24630	COG0640	Transcriptional regulator
VAPAR_RS24645	COG0625	glutathione transferase activity
VAPAR_RS24650	COG0583	DNA-binding transcription factor activity
VAPAR_RS24655	COG1131	(ABC) transporter
VAPAR_RS24665	COG1846	Transcriptional regulator
VAPAR_RS24670	COG1764	response to oxidative stress
VAPAR_RS24680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAPAR_RS24685	COG0583	DNA-binding transcription factor activity
VAPAR_RS24690	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS24695	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS24700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS24715	COG0326	Molecular chaperone. Has ATPase activity
VAPAR_RS24720	COG1840	ABC-type Fe3 transport system, periplasmic component
VAPAR_RS24725	COG0583	DNA-binding transcription factor activity
VAPAR_RS24735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VAPAR_RS24745	COG0642	Histidine kinase
VAPAR_RS24760	COG1187	pseudouridine synthase activity
VAPAR_RS24765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAPAR_RS24785	COG0745	RESPONSE REGULATOR receiver
VAPAR_RS24790	COG2205	protein histidine kinase activity
VAPAR_RS24800	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
VAPAR_RS24805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
VAPAR_RS24810	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
VAPAR_RS24825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VAPAR_RS24840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAPAR_RS24850	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS24860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPAR_RS24865	COG1022	Amp-dependent synthetase and ligase
VAPAR_RS24895	COG0318	PFAM AMP-dependent synthetase and ligase
VAPAR_RS24900	COG0693	protein deglycase activity
VAPAR_RS24935	COG4993	Dehydrogenase
VAPAR_RS24940	COG1940	carbohydrate kinase activity
VAPAR_RS24945	COG1129	ABC transporter
VAPAR_RS24950	COG4214	carbohydrate transport
VAPAR_RS24955	COG4213	ABC transporter substrate-binding protein
VAPAR_RS24965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAPAR_RS24970	COG0583	DNA-binding transcription factor activity
VAPAR_RS24985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VAPAR_RS24990	COG0022	dehydrogenase e1 component
VAPAR_RS25000	COG1028	Short-chain dehydrogenase reductase Sdr
VAPAR_RS25005	COG0583	DNA-binding transcription factor activity
VAPAR_RS25020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAPAR_RS25035	COG1024	Enoyl-CoA hydratase
VAPAR_RS25040	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS25060	COG0203	ribosomal protein L17
VAPAR_RS25065	COG0202	RNA polymerase activity
VAPAR_RS25070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VAPAR_RS25075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VAPAR_RS25080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VAPAR_RS25085	COG0201	protein transport
VAPAR_RS25090	COG0200	Binds to the 23S rRNA
VAPAR_RS25095	COG1841	ribosomal large subunit assembly
VAPAR_RS25100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VAPAR_RS25105	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VAPAR_RS25110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VAPAR_RS25115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VAPAR_RS25120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VAPAR_RS25125	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VAPAR_RS25130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VAPAR_RS25135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VAPAR_RS25155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VAPAR_RS25160	COG0783	Belongs to the Dps family
VAPAR_RS25170	COG1280	lysine exporter protein (LysE YggA)
VAPAR_RS25175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VAPAR_RS25180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VAPAR_RS25190	COG0343	queuine tRNA-ribosyltransferase activity
VAPAR_RS25245	COG0284	orotidine-5'-phosphate decarboxylase activity
VAPAR_RS25260	COG1214	PFAM Peptidase M22, glycoprotease
VAPAR_RS25275	COG0494	nUDIX hydrolase
VAPAR_RS25280	COG2027	D-alanyl-D-alanine carboxypeptidase
VAPAR_RS25290	COG0009	L-threonylcarbamoyladenylate synthase
VAPAR_RS25295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VAPAR_RS25300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VAPAR_RS25315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VAPAR_RS25325	COG1522	sequence-specific DNA binding
VAPAR_RS25330	COG2515	1-aminocyclopropane-1-carboxylate deaminase
VAPAR_RS25335	COG0469	pyruvate kinase activity
VAPAR_RS25340	COG0126	phosphoglycerate kinase activity
VAPAR_RS25360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAPAR_RS25390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VAPAR_RS25400	COG0242	peptide deformylase activity
VAPAR_RS25410	COG0758	DNA mediated transformation
VAPAR_RS25415	COG2922	Belongs to the Smg family
VAPAR_RS25425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAPAR_RS25430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAPAR_RS25435	COG1862	Preprotein translocase
VAPAR_RS25445	COG1522	sequence-specific DNA binding
VAPAR_RS25455	COG0765	amino acid transport
VAPAR_RS25460	COG2814	Major facilitator Superfamily
VAPAR_RS25470	COG1845	cytochrome c oxidase, subunit III
VAPAR_RS25480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VAPAR_RS25485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VAPAR_RS25505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VAPAR_RS25535	COG0251	oxidation-reduction process
VAPAR_RS25545	COG3622	Belongs to the hyi family
VAPAR_RS25550	COG0235	Class ii aldolase
VAPAR_RS25555	COG3395	kinase activity
VAPAR_RS25560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAPAR_RS25565	COG2084	Dehydrogenase
VAPAR_RS25570	COG2271	Major facilitator Superfamily
VAPAR_RS25575	COG2186	Transcriptional regulator
VAPAR_RS25585	COG1522	sequence-specific DNA binding
VAPAR_RS25610	COG4566	intracellular signal transduction
VAPAR_RS25630	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VAPAR_RS25640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VAPAR_RS25645	COG1595	DNA-templated transcription, initiation
VAPAR_RS25660	COG0625	glutathione transferase activity
VAPAR_RS25675	COG4772	TonB-dependent receptor
VAPAR_RS25695	COG0861	Integral membrane protein TerC family
VAPAR_RS25705	COG1950	PFAM Membrane protein of
VAPAR_RS25710	COG4783	chaperone-mediated protein folding
VAPAR_RS25715	COG0315	cyclic pyranopterin monophosphate synthase activity
VAPAR_RS25775	COG0631	protein serine/threonine phosphatase activity
VAPAR_RS25780	COG0861	Integral membrane protein TerC family
VAPAR_RS25785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VAPAR_RS25790	COG0045	succinate-CoA ligase (ADP-forming) activity
VAPAR_RS25795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VAPAR_RS25800	COG2137	regulation of response to DNA damage stimulus
VAPAR_RS25805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VAPAR_RS25820	COG0642	Histidine kinase
VAPAR_RS25830	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VAPAR_RS25830	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VAPAR_RS25850	COG0583	DNA-binding transcription factor activity
VAPAR_RS25855	COG3181	Tripartite tricarboxylate transporter family receptor
VAPAR_RS25865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VAPAR_RS25880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VAPAR_RS25885	COG0513	Belongs to the DEAD box helicase family
VAPAR_RS25900	COG1802	Transcriptional regulator
VAPAR_RS25915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAPAR_RS25930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VAPAR_RS25940	COG1473	amidohydrolase
VAPAR_RS25945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VAPAR_RS25960	COG1802	Transcriptional regulator
VAPAR_RS25970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAPAR_RS25975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAPAR_RS25980	COG4172	Belongs to the ABC transporter superfamily
VAPAR_RS25985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAPAR_RS25995	COG0747	negative chemotaxis
VAPAR_RS26005	COG1741	Belongs to the pirin family
VAPAR_RS26030	COG0765	amino acid transport
VAPAR_RS26050	COG1047	Peptidyl-prolyl cis-trans
VAPAR_RS26090	COG1914	H( )-stimulated, divalent metal cation uptake system
VAPAR_RS26095	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VAPAR_RS26110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAPAR_RS26115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAPAR_RS26120	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VAPAR_RS26125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VAPAR_RS26130	COG0006	proline dipeptidase activity
VAPAR_RS26135	COG0583	DNA-binding transcription factor activity
VAPAR_RS26150	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VAPAR_RS26170	COG0280	phosphate acetyltransferase
VAPAR_RS26170	COG0281	malic enzyme
VAPAR_RS26185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VAPAR_RS26190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAPAR_RS26195	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VAPAR_RS26205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VAPAR_RS26220	COG2814	Major facilitator Superfamily
VAPAR_RS26225	COG2267	carboxylic ester hydrolase activity
VAPAR_RS26245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAPAR_RS26250	COG1739	Uncharacterized protein family UPF0029
VAPAR_RS26255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAPAR_RS26260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VAPAR_RS26265	COG2119	membrane
VAPAR_RS26270	COG0724	RNA recognition motif
VAPAR_RS26275	COG4221	oxidoreductase activity
VAPAR_RS26285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VAPAR_RS26305	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VAPAR_RS26305	COG2066	Belongs to the glutaminase family
VAPAR_RS26310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VAPAR_RS26315	COG0706	membrane insertase activity
VAPAR_RS26320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VAPAR_RS26325	COG0594	ribonuclease P activity
VAPAR_RS26330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VAPAR_RS26540	COG0445	tRNA wobble uridine modification
VAPAR_RS26880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VAPAR_RS27560	COG3971	2-oxopent-4-enoate hydratase activity
VAPAR_RS27575	COG1012	belongs to the aldehyde dehydrogenase family
VAPAR_RS27675	COG2807	transmembrane transport
VAPAR_RS27745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VAPAR_RS27835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAPAR_RS28005	COG0439	Biotin carboxylase
VAPAR_RS28010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VAPAR_RS28075	COG0243	molybdopterin cofactor binding
VAPAR_RS28180	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAPAR_RS28270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAPAR_RS28310	COG0482	sulfurtransferase activity
VAPAR_RS28460	COG0058	SHG alpha-glucan phosphorylase activity
VAPAR_RS28475	COG0297	glycogen (starch) synthase activity
VAPAR_RS28730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VAPAR_RS28935	COG0753	catalase activity
VAPAR_RS29285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAPAR_RS29330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAPAR_RS29380	COG0085	RNA polymerase activity
VAPAR_RS29385	COG0085	RNA polymerase activity
VAPAR_RS29440	COG2272	Belongs to the type-B carboxylesterase lipase family
VAPAR_RS30540	COG1960	acyl-CoA dehydrogenase activity
VAPAR_RS30975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAPAR_RS31035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAPAR_RS31055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VAPAR_RS31075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAPAR_RS31085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAPAR_RS31230	COG0439	Biotin carboxylase
VAPAR_RS31320	COG2943	transferase activity, transferring hexosyl groups
VAPAR_RS31345	COG2205	protein histidine kinase activity
VAPAR_RS31350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAPAR_RS31575	COG2951	lytic endotransglycosylase activity