locus-tag	class	description
IG196_RS00005	COG2080	2 iron, 2 sulfur cluster binding
IG196_RS00010	COG2010	Cytochrome c
IG196_RS00010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG196_RS00150	COG0347	Belongs to the P(II) protein family
IG196_RS00155	COG0004	ammonium transporteR
IG196_RS00165	COG0583	DNA-binding transcription factor activity
IG196_RS00170	COG1620	l-lactate permease
IG196_RS00175	COG0277	FAD linked oxidase domain protein
IG196_RS00180	COG0277	FAD linked oxidase domain protein
IG196_RS00185	COG0247	lactate metabolic process
IG196_RS00195	COG0386	Belongs to the glutathione peroxidase family
IG196_RS00205	COG0477	Major facilitator Superfamily
IG196_RS00210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IG196_RS00230	COG0217	transcriptional regulatory protein
IG196_RS00245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IG196_RS00260	COG0129	dihydroxy-acid dehydratase activity
IG196_RS00270	COG3971	2-oxopent-4-enoate hydratase activity
IG196_RS00290	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS00295	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS00315	COG1846	Transcriptional regulator
IG196_RS00330	COG0583	DNA-binding transcription factor activity
IG196_RS00340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IG196_RS00360	COG2974	May be involved in recombination
IG196_RS00390	COG0745	RESPONSE REGULATOR receiver
IG196_RS00400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IG196_RS00405	COG2211	Major facilitator Superfamily
IG196_RS00430	COG0708	Exodeoxyribonuclease III
IG196_RS00435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IG196_RS00445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IG196_RS00450	COG0154	amidase activity
IG196_RS00455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IG196_RS00460	COG1077	Cell shape determining protein MreB Mrl
IG196_RS00465	COG1792	Involved in formation and maintenance of cell shape
IG196_RS00475	COG0768	penicillin binding
IG196_RS00480	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG196_RS00490	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IG196_RS00500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_RS00515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IG196_RS00540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IG196_RS00545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IG196_RS00550	COG0583	DNA-binding transcription factor activity
IG196_RS00590	COG0436	Aminotransferase
IG196_RS00595	COG0028	Belongs to the TPP enzyme family
IG196_RS00605	COG0004	ammonium transporteR
IG196_RS00625	COG0724	RNA recognition motif
IG196_RS00635	COG0023	Translation Initiation Factor
IG196_RS00640	COG0513	Belongs to the DEAD box helicase family
IG196_RS00645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG196_RS00650	COG2272	Belongs to the type-B carboxylesterase lipase family
IG196_RS00665	COG0330	HflC and HflK could
IG196_RS00670	COG1960	acyl-CoA dehydrogenase activity
IG196_RS00675	COG1960	acyl-CoA dehydrogenase activity
IG196_RS00680	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS00685	COG0439	Biotin carboxylase
IG196_RS00690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG196_RS00705	COG2733	membrane
IG196_RS00720	COG0584	glycerophosphoryl diester phosphodiesterase
IG196_RS00725	COG1473	amidohydrolase
IG196_RS00740	COG0243	molybdopterin cofactor binding
IG196_RS00755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS00785	COG0583	DNA-binding transcription factor activity
IG196_RS00800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_RS00810	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS00815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG196_RS00825	COG1946	Acyl-CoA thioesterase
IG196_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS00845	COG0659	secondary active sulfate transmembrane transporter activity
IG196_RS00890	COG0667	Aldo Keto reductase
IG196_RS00895	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_RS00910	COG1070	Carbohydrate kinase
IG196_RS00915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IG196_RS00920	COG2188	Transcriptional regulator
IG196_RS00935	COG0629	single-stranded DNA binding
IG196_RS00965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_RS00970	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS00975	COG0482	sulfurtransferase activity
IG196_RS00995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IG196_RS01010	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS01015	COG0601	transmembrane transport
IG196_RS01020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_RS01025	COG0444	Belongs to the ABC transporter superfamily
IG196_RS01030	COG4608	Belongs to the ABC transporter superfamily
IG196_RS01035	COG0747	negative chemotaxis
IG196_RS01060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IG196_RS01070	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IG196_RS01075	COG0735	belongs to the Fur family
IG196_RS01080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG196_RS01085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IG196_RS01100	COG0058	SHG alpha-glucan phosphorylase activity
IG196_RS01105	COG0297	glycogen (starch) synthase activity
IG196_RS01110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IG196_RS01125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG196_RS01130	COG0366	Alpha amylase catalytic
IG196_RS01135	COG2072	flavoprotein involved in K transport
IG196_RS01140	COG0495	leucyl-tRNA aminoacylation
IG196_RS01155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IG196_RS01165	COG3158	transport of potassium into the cell
IG196_RS01170	COG3135	benzoate transporter
IG196_RS01175	COG0189	ligase activity
IG196_RS01190	COG0121	glutamine amidotransferase
IG196_RS01200	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS01205	COG0154	amidase activity
IG196_RS01225	COG2814	Major facilitator Superfamily
IG196_RS01240	COG0205	6-phosphofructokinase activity
IG196_RS01255	COG0583	DNA-binding transcription factor activity
IG196_RS01260	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IG196_RS01275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IG196_RS01280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG196_RS01285	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS01290	COG1414	Transcriptional regulator
IG196_RS01295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_RS01300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS01320	COG0018	arginyl-trna synthetase
IG196_RS01330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IG196_RS01335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IG196_RS01340	COG1137	ATPase activity
IG196_RS01345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IG196_RS01350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_RS01355	COG1280	lysine exporter protein (LysE YggA)
IG196_RS01365	COG2353	YceI-like domain
IG196_RS01370	COG3038	cytochrome b561
IG196_RS01405	COG0069	glutamate synthase activity
IG196_RS01435	COG2197	response regulator
IG196_RS01450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IG196_RS01460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_RS01465	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS01495	COG1335	isochorismatase
IG196_RS01500	COG4977	sequence-specific DNA binding
IG196_RS01505	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IG196_RS01520	COG2967	ApaG domain
IG196_RS01525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IG196_RS01545	COG0753	catalase activity
IG196_RS01545	COG0693	protein deglycase activity
IG196_RS01560	COG3210	domain, Protein
IG196_RS01580	COG5002	protein histidine kinase activity
IG196_RS01595	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IG196_RS01600	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IG196_RS01630	COG0515	serine threonine protein kinase
IG196_RS01765	COG0546	phosphoglycolate phosphatase activity
IG196_RS01795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IG196_RS01800	COG0134	indole-3-glycerol-phosphate synthase activity
IG196_RS01805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IG196_RS01825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IG196_RS01835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IG196_RS01845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IG196_RS01850	COG0081	regulation of translation
IG196_RS01855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IG196_RS01860	COG0222	ribosome binding
IG196_RS01865	COG0085	RNA polymerase activity
IG196_RS01870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IG196_RS01880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG196_RS01880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IG196_RS01890	COG5000	phosphorelay sensor kinase activity
IG196_RS01895	COG2204	response regulator
IG196_RS01945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IG196_RS01960	COG0210	DNA helicase
IG196_RS01965	COG0679	Auxin Efflux Carrier
IG196_RS01985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IG196_RS01990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IG196_RS02005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG196_RS02010	COG4232	protein-disulfide reductase activity
IG196_RS02015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IG196_RS02025	COG1609	Transcriptional regulator
IG196_RS02055	COG0583	DNA-binding transcription factor activity
IG196_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS02070	COG1215	transferase activity, transferring glycosyl groups
IG196_RS02075	COG1649	PFAM Uncharacterised BCR, COG1649
IG196_RS02075	COG0726	polysaccharide deacetylase
IG196_RS02090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG196_RS02095	COG1280	lysine exporter protein (LysE YggA)
IG196_RS02105	COG0384	phenazine biosynthesis protein PhzF
IG196_RS02110	COG0625	glutathione transferase activity
IG196_RS02115	COG0384	phenazine biosynthesis protein PhzF
IG196_RS02130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_RS02140	COG0697	spore germination
IG196_RS02170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_RS02215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IG196_RS02235	COG3959	Transketolase, thiamine diphosphate binding domain
IG196_RS02240	COG3958	Transketolase
IG196_RS02250	COG0463	Glycosyl transferase, family 2
IG196_RS02280	COG0463	Glycosyl transferase, family 2
IG196_RS02290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IG196_RS02290	COG2755	lipolytic protein G-D-S-L family
IG196_RS02300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IG196_RS02305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IG196_RS02310	COG1309	transcriptional regulator
IG196_RS02320	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IG196_RS02325	COG2721	sulfolactate sulfo-lyase activity
IG196_RS02330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_RS02340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS02345	COG2186	Transcriptional regulator
IG196_RS02350	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS02355	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS02360	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG196_RS02365	COG0583	DNA-binding transcription factor activity
IG196_RS02370	COG4221	oxidoreductase activity
IG196_RS02380	COG1960	acyl-CoA dehydrogenase activity
IG196_RS02390	COG1024	Enoyl-CoA hydratase
IG196_RS02390	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_RS02395	COG0183	Belongs to the thiolase family
IG196_RS02415	COG1024	Enoyl-CoA hydratase
IG196_RS02420	COG0683	leucine binding
IG196_RS02430	COG5265	(ABC) transporter
IG196_RS02435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG196_RS02445	COG3712	iron ion homeostasis
IG196_RS02450	COG1595	DNA-templated transcription, initiation
IG196_RS02455	COG0154	amidase activity
IG196_RS02460	COG0583	DNA-binding transcription factor activity
IG196_RS02465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_RS02470	COG0765	amino acid transport
IG196_RS02475	COG0765	amino acid transport
IG196_RS02480	COG1126	abc transporter atp-binding protein
IG196_RS02495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS02500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_RS02500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_RS02505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_RS02510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG196_RS02515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_RS02565	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS02575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS02580	COG1024	Enoyl-CoA hydratase
IG196_RS02585	COG1960	acyl-CoA dehydrogenase activity
IG196_RS02590	COG1960	acyl-CoA dehydrogenase activity
IG196_RS02595	COG0183	Belongs to the thiolase family
IG196_RS02600	COG1024	Enoyl-CoA hydratase
IG196_RS02600	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_RS02605	COG0583	DNA-binding transcription factor activity
IG196_RS02615	COG0154	amidase activity
IG196_RS02620	COG0444	Belongs to the ABC transporter superfamily
IG196_RS02625	COG4608	Belongs to the ABC transporter superfamily
IG196_RS02630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_RS02640	COG0747	negative chemotaxis
IG196_RS02665	COG1595	DNA-templated transcription, initiation
IG196_RS02670	COG0418	dihydroorotase activity
IG196_RS02690	COG0501	Belongs to the peptidase M48B family
IG196_RS02700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG196_RS02705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IG196_RS02710	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IG196_RS02725	COG3604	Transcriptional regulator
IG196_RS02755	COG1566	PFAM secretion protein HlyD family protein
IG196_RS02770	COG1187	pseudouridine synthase activity
IG196_RS02775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG196_RS02780	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS02805	COG2807	transmembrane transport
IG196_RS02810	COG0590	tRNA wobble adenosine to inosine editing
IG196_RS02830	COG0656	L-ascorbic acid biosynthetic process
IG196_RS02835	COG2814	Major facilitator Superfamily
IG196_RS02855	COG0583	DNA-binding transcription factor activity
IG196_RS02860	COG1335	isochorismatase
IG196_RS02895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IG196_RS02910	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IG196_RS02920	COG0523	cobalamin synthesis protein
IG196_RS02940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IG196_RS02945	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IG196_RS02950	COG2001	Belongs to the MraZ family
IG196_RS02955	COG0275	rRNA processing
IG196_RS02970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IG196_RS02975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IG196_RS02980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IG196_RS02985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IG196_RS02990	COG0772	Belongs to the SEDS family
IG196_RS02995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IG196_RS03000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IG196_RS03005	COG1181	Belongs to the D-alanine--D-alanine ligase family
IG196_RS03010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IG196_RS03025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IG196_RS03035	COG0583	DNA-binding transcription factor activity
IG196_RS03040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG196_RS03045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IG196_RS03055	COG0575	Belongs to the CDS family
IG196_RS03075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG196_RS03090	COG3150	esterase
IG196_RS03095	COG2197	response regulator
IG196_RS03105	COG0772	Belongs to the SEDS family
IG196_RS03110	COG0312	modulator of DNA gyrase
IG196_RS03120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IG196_RS03130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IG196_RS03140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG196_RS03145	COG0511	ligase activity, forming carbon-carbon bonds
IG196_RS03150	COG0439	Biotin carboxylase
IG196_RS03155	COG2264	protein methyltransferase activity
IG196_RS03165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG196_RS03175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IG196_RS03205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IG196_RS03210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IG196_RS03235	COG2204	response regulator
IG196_RS03245	COG2205	protein histidine kinase activity
IG196_RS03250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IG196_RS03260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_RS03285	COG0037	tRNA processing
IG196_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS03305	COG2175	clavaminate synthase activity
IG196_RS03315	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IG196_RS03320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS03340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_RS03350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG196_RS03360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_RS03375	COG0583	DNA-binding transcription factor activity
IG196_RS03380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IG196_RS03385	COG0739	heme binding
IG196_RS03385	COG1196	nuclear chromosome segregation
IG196_RS03385	COG0741	lytic transglycosylase activity
IG196_RS03405	COG0617	tRNA 3'-terminal CCA addition
IG196_RS03415	COG3387	PFAM Glycoside hydrolase 15-related
IG196_RS03420	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IG196_RS03455	COG2205	protein histidine kinase activity
IG196_RS03475	COG2832	Protein of unknown function (DUF454)
IG196_RS03485	COG5295	Hep Hag repeat protein
IG196_RS03495	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IG196_RS03495	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IG196_RS03495	COG0506	proline dehydrogenase activity
IG196_RS03515	COG0697	spore germination
IG196_RS03520	COG0583	DNA-binding transcription factor activity
IG196_RS03525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IG196_RS03540	COG3386	PFAM SMP-30 Gluconolaconase
IG196_RS03545	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS03555	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS03560	COG1879	ABC-type sugar transport system periplasmic component
IG196_RS03565	COG4213	ABC transporter substrate-binding protein
IG196_RS03575	COG4214	carbohydrate transport
IG196_RS03580	COG1129	ABC transporter
IG196_RS03585	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_RS03590	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_RS03620	COG0189	ligase activity
IG196_RS03620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IG196_RS03625	COG0189	ligase activity
IG196_RS03625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IG196_RS03630	COG1132	(ABC) transporter
IG196_RS03640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IG196_RS03645	COG4178	(ABC) transporter
IG196_RS03650	COG1840	ABC-type Fe3 transport system, periplasmic component
IG196_RS03655	COG3842	ATPase activity
IG196_RS03660	COG4149	molybdate abc transporter
IG196_RS03675	COG2271	Major facilitator Superfamily
IG196_RS03690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_RS03700	COG2863	cytochrome
IG196_RS03715	COG2233	PERMEase
IG196_RS03720	COG0583	DNA-binding transcription factor activity
IG196_RS03805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG196_RS03810	COG1765	OsmC-like protein
IG196_RS03815	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IG196_RS03830	COG1473	amidohydrolase
IG196_RS03840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_RS03845	COG0444	Belongs to the ABC transporter superfamily
IG196_RS03850	COG4608	Belongs to the ABC transporter superfamily
IG196_RS03865	COG3384	dioxygenase
IG196_RS03870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IG196_RS03875	COG1840	ABC-type Fe3 transport system, periplasmic component
IG196_RS03900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IG196_RS03905	COG0166	Belongs to the GPI family
IG196_RS03935	COG1175	transmembrane transport
IG196_RS03940	COG0395	ABC-type sugar transport system, permease component
IG196_RS03950	COG0246	Mannitol dehydrogenase
IG196_RS03960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IG196_RS03970	COG4753	response regulator
IG196_RS03970	COG2207	Transcriptional regulator
IG196_RS03975	COG1070	Carbohydrate kinase
IG196_RS03980	COG0459	protein refolding
IG196_RS03985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IG196_RS03990	COG1595	DNA-templated transcription, initiation
IG196_RS03995	COG3712	iron ion homeostasis
IG196_RS04000	COG4774	siderophore transport
IG196_RS04025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_RS04030	COG4774	siderophore transport
IG196_RS04045	COG4772	TonB-dependent receptor
IG196_RS04050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IG196_RS04060	COG1560	Kdo2-lipid A biosynthetic process
IG196_RS04070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IG196_RS04080	COG1333	cytochrome c biogenesis protein
IG196_RS04085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IG196_RS04090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IG196_RS04095	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IG196_RS04100	COG0019	diaminopimelate decarboxylase activity
IG196_RS04110	COG1965	Belongs to the frataxin family
IG196_RS04145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IG196_RS04150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IG196_RS04155	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IG196_RS04180	COG0070	glutamate synthase
IG196_RS04180	COG0069	glutamate synthase activity
IG196_RS04180	COG0067	glutamate synthase
IG196_RS04190	COG1127	ABC transporter
IG196_RS04195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IG196_RS04200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IG196_RS04205	COG2853	Lipoprotein
IG196_RS04225	COG1131	(ABC) transporter
IG196_RS04230	COG0842	Transport permease protein
IG196_RS04235	COG5007	Belongs to the BolA IbaG family
IG196_RS04240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IG196_RS04245	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IG196_RS04265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG196_RS04270	COG0131	Imidazoleglycerol-phosphate dehydratase
IG196_RS04280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IG196_RS04285	COG2814	Major facilitator Superfamily
IG196_RS04290	COG0583	DNA-binding transcription factor activity
IG196_RS04300	COG1301	dicarboxylic acid transport
IG196_RS04310	COG0107	imidazoleglycerol-phosphate synthase activity
IG196_RS04315	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IG196_RS04320	COG0140	phosphoribosyl-ATP diphosphatase activity
IG196_RS04330	COG0537	adenosine 5'-monophosphoramidase activity
IG196_RS04335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IG196_RS04340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IG196_RS04345	COG0805	protein transport
IG196_RS04360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IG196_RS04365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IG196_RS04370	COG1970	mechanosensitive ion channel activity
IG196_RS04375	COG1596	polysaccharide export
IG196_RS04380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IG196_RS04420	COG1086	Polysaccharide biosynthesis protein
IG196_RS04445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IG196_RS04460	COG0489	protein tyrosine kinase activity
IG196_RS04460	COG3206	protein involved in exopolysaccharide biosynthesis
IG196_RS04465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG196_RS04475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG196_RS04490	COG0723	plastoquinol--plastocyanin reductase activity
IG196_RS04495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IG196_RS04500	COG2857	Cytochrome c1
IG196_RS04505	COG0625	glutathione transferase activity
IG196_RS04510	COG2969	positive regulation of protein catabolic process
IG196_RS04530	COG1850	ribulose-bisphosphate carboxylase activity
IG196_RS04540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_RS04545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS04550	COG1609	Transcriptional regulator
IG196_RS04650	COG1595	DNA-templated transcription, initiation
IG196_RS04670	COG2226	methyltransferase
IG196_RS04685	COG2824	Alkylphosphonate utilization operon protein PhnA
IG196_RS04700	COG0640	Transcriptional regulator
IG196_RS04715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG196_RS04725	COG0798	PFAM Bile acid sodium symporter
IG196_RS04745	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IG196_RS04750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IG196_RS04790	COG1595	DNA-templated transcription, initiation
IG196_RS04805	COG1595	DNA-templated transcription, initiation
IG196_RS04815	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS04825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IG196_RS04835	COG4591	ABC-type transport system involved in lipoprotein release permease component
IG196_RS04840	COG1136	(ABC) transporter
IG196_RS04870	COG0740	serine-type endopeptidase activity
IG196_RS04890	COG0601	transmembrane transport
IG196_RS04920	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IG196_RS04975	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS05010	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IG196_RS05030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG196_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS05050	COG2030	dehydratase
IG196_RS05050	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS05075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IG196_RS05080	COG2151	metal-sulfur cluster biosynthetic enzyme
IG196_RS05085	COG3396	Phenylacetate-CoA oxygenase
IG196_RS05090	COG3460	Phenylacetate-CoA oxygenase
IG196_RS05095	COG3396	Phenylacetate-CoA oxygenase
IG196_RS05105	COG2050	protein possibly involved in aromatic compounds catabolism
IG196_RS05110	COG1024	Enoyl-CoA hydratase
IG196_RS05120	COG1309	transcriptional regulator
IG196_RS05125	COG2304	oxidoreductase activity
IG196_RS05135	COG0714	Associated with various cellular activities
IG196_RS05140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_RS05145	COG0084	hydrolase, TatD family'
IG196_RS05160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IG196_RS05165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IG196_RS05195	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS05215	COG0583	DNA-binding transcription factor activity
IG196_RS05230	COG1283	sodium-dependent phosphate transmembrane transporter activity
IG196_RS05235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IG196_RS05240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IG196_RS05260	COG1609	Transcriptional regulator
IG196_RS05275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IG196_RS05285	COG0196	riboflavin kinase activity
IG196_RS05295	COG1024	Enoyl-CoA hydratase
IG196_RS05310	COG1960	acyl-CoA dehydrogenase activity
IG196_RS05315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IG196_RS05335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IG196_RS05335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG196_RS05345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IG196_RS05350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IG196_RS05355	COG0492	ferredoxin-NADP+ reductase activity
IG196_RS05365	COG1674	ftsk spoiiie
IG196_RS05370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IG196_RS05375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IG196_RS05380	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_RS05450	COG2816	NAD+ diphosphatase activity
IG196_RS05455	COG0425	Belongs to the sulfur carrier protein TusA family
IG196_RS05465	COG0525	valine-tRNA ligase activity
IG196_RS05470	COG3022	response to hydroperoxide
IG196_RS05480	COG2267	carboxylic ester hydrolase activity
IG196_RS05485	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IG196_RS05485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IG196_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS05505	COG4948	Mandelate Racemase Muconate Lactonizing
IG196_RS05510	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS05525	COG1960	acyl-CoA dehydrogenase activity
IG196_RS05535	COG1960	acyl-CoA dehydrogenase activity
IG196_RS05545	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS05575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IG196_RS05605	COG1283	sodium-dependent phosphate transmembrane transporter activity
IG196_RS05610	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
IG196_RS05625	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS05630	COG0583	DNA-binding transcription factor activity
IG196_RS05635	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG196_RS05650	COG2186	Transcriptional regulator
IG196_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS05680	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_RS05690	COG4948	Mandelate Racemase Muconate Lactonizing
IG196_RS05695	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS05700	COG3254	rhamnose metabolic process
IG196_RS05740	COG0583	DNA-binding transcription factor activity
IG196_RS05755	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IG196_RS05760	COG4221	oxidoreductase activity
IG196_RS05790	COG4166	transmembrane transport
IG196_RS05795	COG0601	transmembrane transport
IG196_RS05805	COG4172	Belongs to the ABC transporter superfamily
IG196_RS05815	COG1473	amidohydrolase
IG196_RS05820	COG2807	transmembrane transport
IG196_RS05825	COG2186	Transcriptional regulator
IG196_RS05830	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IG196_RS05835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IG196_RS05840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IG196_RS05860	COG1280	lysine exporter protein (LysE YggA)
IG196_RS05945	COG4566	intracellular signal transduction
IG196_RS05950	COG0477	Major facilitator Superfamily
IG196_RS05960	COG0165	Argininosuccinate lyase
IG196_RS05965	COG3275	phosphorelay sensor kinase activity
IG196_RS05985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG196_RS05990	COG2271	Major facilitator Superfamily
IG196_RS06000	COG0583	DNA-binding transcription factor activity
IG196_RS06015	COG3459	Glycosyltransferase 36 associated
IG196_RS06025	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IG196_RS06030	COG0181	hydroxymethylbilane synthase activity
IG196_RS06035	COG1587	Uroporphyrinogen-III synthase
IG196_RS06055	COG0583	DNA-binding transcription factor activity
IG196_RS06060	COG1530	ribonuclease E activity
IG196_RS06080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IG196_RS06080	COG0616	signal peptide processing
IG196_RS06085	COG2223	nitrite transmembrane transporter activity
IG196_RS06090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IG196_RS06095	COG0424	maF-like protein
IG196_RS06105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IG196_RS06110	COG0416	fatty acid biosynthetic process
IG196_RS06115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG196_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS06130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IG196_RS06135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IG196_RS06160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_RS06165	COG0481	GTPase activity
IG196_RS06170	COG0681	Belongs to the peptidase S26 family
IG196_RS06180	COG0571	ribonuclease III activity
IG196_RS06185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IG196_RS06190	COG1381	Involved in DNA repair and RecF pathway recombination
IG196_RS06200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IG196_RS06205	COG0736	holo-[acyl-carrier-protein] synthase activity
IG196_RS06210	COG1472	Belongs to the glycosyl hydrolase 3 family
IG196_RS06220	COG1451	nucleotide metabolic process
IG196_RS06225	COG0443	Heat shock 70 kDa protein
IG196_RS06240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IG196_RS06255	COG0762	integral membrane protein
IG196_RS06260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IG196_RS06265	COG0159	tryptophan synthase activity
IG196_RS06270	COG0133	tryptophan synthase activity
IG196_RS06275	COG0135	phosphoribosylanthranilate isomerase activity
IG196_RS06280	COG0101	tRNA pseudouridine synthase activity
IG196_RS06290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IG196_RS06295	COG0473	3-isopropylmalate dehydrogenase activity
IG196_RS06300	COG0066	3-isopropylmalate dehydratase activity
IG196_RS06305	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IG196_RS06315	COG0372	Belongs to the citrate synthase family
IG196_RS06320	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IG196_RS06325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IG196_RS06330	COG1053	succinate dehydrogenase
IG196_RS06345	COG2188	Transcriptional regulator
IG196_RS06350	COG0039	L-malate dehydrogenase activity
IG196_RS06355	COG4106	trans-aconitate 2-methyltransferase activity
IG196_RS06370	COG1049	propionate catabolic process, 2-methylcitrate cycle
IG196_RS06425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IG196_RS06435	COG0672	)-iron permease
IG196_RS06440	COG2822	iron ion transport
IG196_RS06450	COG2822	iron ion transport
IG196_RS06460	COG1918	ferrous iron import across plasma membrane
IG196_RS06460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IG196_RS06470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_RS06485	COG0628	permease
IG196_RS06495	COG1301	dicarboxylic acid transport
IG196_RS06535	COG0583	DNA-binding transcription factor activity
IG196_RS06590	COG0366	Alpha amylase catalytic
IG196_RS06595	COG1942	4-Oxalocrotonate Tautomerase
IG196_RS06610	COG0284	orotidine-5'-phosphate decarboxylase activity
IG196_RS06645	COG0154	amidase activity
IG196_RS06655	COG4608	Belongs to the ABC transporter superfamily
IG196_RS06660	COG0444	Belongs to the ABC transporter superfamily
IG196_RS06665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_RS06675	COG0473	3-isopropylmalate dehydrogenase activity
IG196_RS06680	COG0656	L-ascorbic acid biosynthetic process
IG196_RS06685	COG2233	PERMEase
IG196_RS06700	COG1309	transcriptional regulator
IG196_RS06715	COG1953	Uracil, thiamine, allantoin
IG196_RS06730	COG4774	siderophore transport
IG196_RS06755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG196_RS06770	COG2186	Transcriptional regulator
IG196_RS06775	COG2351	hydroxyisourate hydrolase activity
IG196_RS06830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG196_RS06860	COG0730	response to heat
IG196_RS06870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG196_RS06880	COG2252	PERMEase
IG196_RS06885	COG3845	ABC transporter
IG196_RS06920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG196_RS06925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IG196_RS06930	COG2814	Major facilitator Superfamily
IG196_RS06935	COG0583	DNA-binding transcription factor activity
IG196_RS06940	COG4977	sequence-specific DNA binding
IG196_RS06945	COG2366	antibiotic biosynthetic process
IG196_RS06960	COG0402	S-adenosylhomocysteine deaminase activity
IG196_RS06965	COG0717	Belongs to the dCTP deaminase family
IG196_RS06970	COG2321	neutral zinc metallopeptidase
IG196_RS06975	COG0513	Belongs to the DEAD box helicase family
IG196_RS06990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_RS06995	COG1960	acyl-CoA dehydrogenase activity
IG196_RS07005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_RS07015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_RS07020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS07025	COG1116	anion transmembrane transporter activity
IG196_RS07045	COG2197	response regulator
IG196_RS07065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IG196_RS07070	COG1253	flavin adenine dinucleotide binding
IG196_RS07080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IG196_RS07085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IG196_RS07120	COG0583	DNA-binding transcription factor activity
IG196_RS07140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IG196_RS07155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IG196_RS07160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IG196_RS07240	COG0516	GMP reductase activity
IG196_RS07245	COG3047	cAMP biosynthetic process
IG196_RS07250	COG0210	DNA helicase
IG196_RS07270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IG196_RS07290	COG0583	DNA-binding transcription factor activity
IG196_RS07295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IG196_RS07305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG196_RS07320	COG4774	siderophore transport
IG196_RS07345	COG0412	Dienelactone hydrolase
IG196_RS07365	COG4172	Belongs to the ABC transporter superfamily
IG196_RS07370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_RS07375	COG0601	transmembrane transport
IG196_RS07380	COG4166	transmembrane transport
IG196_RS07390	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IG196_RS07395	COG4608	Belongs to the ABC transporter superfamily
IG196_RS07400	COG0444	Belongs to the ABC transporter superfamily
IG196_RS07405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_RS07410	COG0601	transmembrane transport
IG196_RS07415	COG0747	negative chemotaxis
IG196_RS07445	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS07465	COG2030	dehydratase
IG196_RS07480	COG2079	MmgE PrpD family protein
IG196_RS07485	COG2301	Belongs to the HpcH HpaI aldolase family
IG196_RS07550	COG2226	methyltransferase
IG196_RS07560	COG3064	Membrane
IG196_RS07600	COG1722	exodeoxyribonuclease VII activity
IG196_RS07605	COG0142	geranyltranstransferase activity
IG196_RS07610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IG196_RS07615	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IG196_RS07620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_RS07630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IG196_RS07635	COG0477	Major facilitator Superfamily
IG196_RS07650	COG3842	ATPase activity
IG196_RS07655	COG1840	ABC-type Fe3 transport system, periplasmic component
IG196_RS07660	COG1802	Transcriptional regulator
IG196_RS07670	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS07680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_RS07700	COG2188	Transcriptional regulator
IG196_RS07710	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_RS07785	COG3608	succinylglutamate desuccinylase aspartoacylase
IG196_RS07785	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IG196_RS07810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS07815	COG1309	transcriptional regulator
IG196_RS07825	COG1320	monovalent cation:proton antiporter activity
IG196_RS07830	COG2212	antiporter activity
IG196_RS07840	COG0651	ATP synthesis coupled electron transport
IG196_RS07845	COG1006	Multisubunit Na H antiporter MnhC subunit
IG196_RS07850	COG2111	Na H antiporter
IG196_RS07850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IG196_RS07855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IG196_RS07860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_RS07860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_RS07870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS07880	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IG196_RS07900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IG196_RS07905	COG0287	Prephenate dehydrogenase
IG196_RS07910	COG0077	Prephenate dehydratase
IG196_RS07910	COG1605	Chorismate mutase
IG196_RS07915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IG196_RS07935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IG196_RS07955	COG0582	viral genome integration into host DNA
IG196_RS08060	COG5377	YqaJ viral recombinase family
IG196_RS08135	COG4569	acetaldehyde dehydrogenase (acetylating) activity
IG196_RS08140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_RS08155	COG0596	Alpha beta hydrolase
IG196_RS08190	COG2755	lipolytic protein G-D-S-L family
IG196_RS08190	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IG196_RS08200	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS08205	COG0583	DNA-binding transcription factor activity
IG196_RS08210	COG0753	catalase activity
IG196_RS08215	COG1764	response to oxidative stress
IG196_RS08220	COG2353	YceI-like domain
IG196_RS08255	COG0625	glutathione transferase activity
IG196_RS08280	COG1741	Belongs to the pirin family
IG196_RS08295	COG0625	glutathione transferase activity
IG196_RS08300	COG2807	transmembrane transport
IG196_RS08305	COG2207	Transcriptional regulator
IG196_RS08310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IG196_RS08325	COG1454	alcohol dehydrogenase
IG196_RS08330	COG0583	DNA-binding transcription factor activity
IG196_RS08335	COG0655	NAD(P)H dehydrogenase (quinone) activity
IG196_RS08340	COG0346	lactoylglutathione lyase activity
IG196_RS08350	COG3483	tryptophan 2,3-dioxygenase activity
IG196_RS08355	COG0154	amidase activity
IG196_RS08385	COG0583	DNA-binding transcription factor activity
IG196_RS08395	COG2205	protein histidine kinase activity
IG196_RS08415	COG2197	response regulator
IG196_RS08420	COG2197	response regulator
IG196_RS08455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG196_RS08465	COG1126	abc transporter atp-binding protein
IG196_RS08470	COG0765	amino acid transport
IG196_RS08475	COG0626	cystathionine gamma-synthase activity
IG196_RS08480	COG0583	DNA-binding transcription factor activity
IG196_RS08485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_RS08490	COG2205	protein histidine kinase activity
IG196_RS08500	COG0745	RESPONSE REGULATOR receiver
IG196_RS08530	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IG196_RS08535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IG196_RS08550	COG2205	protein histidine kinase activity
IG196_RS08635	COG0601	transmembrane transport
IG196_RS08640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_RS08645	COG0444	Belongs to the ABC transporter superfamily
IG196_RS08710	COG0534	Mate efflux family protein
IG196_RS08715	COG1538	Outer membrane efflux protein
IG196_RS08735	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS08740	COG0583	DNA-binding transcription factor activity
IG196_RS08755	COG0768	penicillin binding
IG196_RS08760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_RS08775	COG1595	DNA-templated transcription, initiation
IG196_RS08800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_RS08815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG196_RS08835	COG2132	Multicopper oxidase
IG196_RS08865	COG2197	response regulator
IG196_RS08870	COG2197	response regulator
IG196_RS08900	COG2271	Major facilitator Superfamily
IG196_RS08930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_RS08930	COG4797	methyltransferase
IG196_RS08965	COG1546	Belongs to the CinA family
IG196_RS08965	COG1058	Belongs to the CinA family
IG196_RS08970	COG0174	glutamine synthetase
IG196_RS08980	COG3852	Histidine kinase
IG196_RS08995	COG0708	Exodeoxyribonuclease III
IG196_RS09010	COG0303	'Molybdopterin
IG196_RS09015	COG0303	'Molybdopterin
IG196_RS09035	COG0437	4 iron, 4 sulfur cluster binding
IG196_RS09040	COG3383	formate dehydrogenase (NAD+) activity
IG196_RS09040	COG0243	molybdopterin cofactor binding
IG196_RS09070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IG196_RS09075	COG0596	Alpha beta hydrolase
IG196_RS09085	COG1764	response to oxidative stress
IG196_RS09130	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS09150	COG1137	ATPase activity
IG196_RS09170	COG3485	protocatechuate 3,4-dioxygenase
IG196_RS09210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS09230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IG196_RS09235	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IG196_RS09245	COG0535	radical SAM domain protein
IG196_RS09260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_RS09265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_RS09270	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IG196_RS09275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS09285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS09290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IG196_RS09315	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IG196_RS09335	COG0277	FAD linked oxidase domain protein
IG196_RS09345	COG1295	ribonuclease BN
IG196_RS09355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG196_RS09365	COG2267	carboxylic ester hydrolase activity
IG196_RS09385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IG196_RS09390	COG0583	DNA-binding transcription factor activity
IG196_RS09410	COG1414	Transcriptional regulator
IG196_RS09415	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS09420	COG4638	Rieske (2fe-2S)
IG196_RS09465	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IG196_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS09520	COG0431	NADPH-dependent FMN reductase
IG196_RS09535	COG0640	Transcriptional regulator
IG196_RS09550	COG3070	regulator of competence-specific genes
IG196_RS09555	COG0346	lactoylglutathione lyase activity
IG196_RS09565	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG196_RS09580	COG0625	glutathione transferase activity
IG196_RS09600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IG196_RS09605	COG2719	SpoVR family
IG196_RS09610	COG2718	Belongs to the UPF0229 family
IG196_RS09615	COG2766	serine protein kinase
IG196_RS09620	COG0484	heat shock protein binding
IG196_RS09625	COG0443	Heat shock 70 kDa protein
IG196_RS09630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IG196_RS09645	COG0688	phosphatidylethanolamine metabolic process
IG196_RS09665	COG2721	sulfolactate sulfo-lyase activity
IG196_RS09670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_RS09680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS09690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG196_RS09695	COG2186	Transcriptional regulator
IG196_RS09700	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS09705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG196_RS09715	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS09730	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS09750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_RS09760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IG196_RS09770	COG1802	Transcriptional regulator
IG196_RS09805	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG196_RS09825	COG0583	DNA-binding transcription factor activity
IG196_RS09830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_RS09835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS09850	COG2814	Major facilitator Superfamily
IG196_RS09865	COG1295	ribonuclease BN
IG196_RS09865	COG1959	2 iron, 2 sulfur cluster binding
IG196_RS09880	COG0123	including yeast histone deacetylase and acetoin utilization protein
IG196_RS09895	COG3237	CsbD-like
IG196_RS09900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IG196_RS09910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG196_RS09925	COG0477	Major facilitator Superfamily
IG196_RS09940	COG1611	Belongs to the LOG family
IG196_RS09945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IG196_RS09960	COG0405	Gamma-glutamyltransferase
IG196_RS09965	COG0322	excinuclease ABC activity
IG196_RS09970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IG196_RS09980	COG0583	DNA-binding transcription factor activity
IG196_RS09985	COG0596	Alpha beta hydrolase
IG196_RS09990	COG0473	3-isopropylmalate dehydrogenase activity
IG196_RS10005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IG196_RS10040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IG196_RS10045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IG196_RS10060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IG196_RS10065	COG0670	Belongs to the BI1 family
IG196_RS10070	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IG196_RS10100	COG3128	pkhd-type hydroxylase
IG196_RS10105	COG4774	siderophore transport
IG196_RS10110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IG196_RS10115	COG1477	protein flavinylation
IG196_RS10150	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IG196_RS10165	COG0360	Binds together with S18 to 16S ribosomal RNA
IG196_RS10170	COG2965	DNA replication, synthesis of RNA primer
IG196_RS10175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IG196_RS10180	COG0359	binds to the 23S rRNA
IG196_RS10185	COG0305	Participates in initiation and elongation during chromosome replication
IG196_RS10215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IG196_RS10220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IG196_RS10230	COG0436	Aminotransferase
IG196_RS10245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IG196_RS10250	COG1763	Mo-molybdopterin cofactor biosynthetic process
IG196_RS10255	COG0303	'Molybdopterin
IG196_RS10265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG196_RS10275	COG0314	molybdopterin synthase activity
IG196_RS10285	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS10290	COG0542	response to heat
IG196_RS10300	COG1022	Amp-dependent synthetase and ligase
IG196_RS10330	COG1309	transcriptional regulator
IG196_RS10335	COG1024	Enoyl-CoA hydratase
IG196_RS10340	COG0183	Belongs to the thiolase family
IG196_RS10365	COG0583	DNA-binding transcription factor activity
IG196_RS10385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IG196_RS10400	COG2814	Major facilitator Superfamily
IG196_RS10410	COG0789	Transcriptional regulator
IG196_RS10425	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS10430	COG4974	Belongs to the 'phage' integrase family
IG196_RS10435	COG0583	DNA-binding transcription factor activity
IG196_RS10440	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IG196_RS10445	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IG196_RS10465	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS10470	COG1309	transcriptional regulator
IG196_RS10475	COG0183	Belongs to the thiolase family
IG196_RS10490	COG2833	Protein of unknown function (DUF455)
IG196_RS10500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IG196_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS10535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IG196_RS10540	COG0148	phosphopyruvate hydratase activity
IG196_RS10550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IG196_RS10555	COG0504	CTP synthase activity
IG196_RS10560	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IG196_RS10570	COG0756	dUTP diphosphatase activity
IG196_RS10580	COG1047	Peptidyl-prolyl cis-trans
IG196_RS10585	COG2850	peptidyl-arginine hydroxylation
IG196_RS10600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IG196_RS10605	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IG196_RS10610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG196_RS10625	COG2814	Major facilitator Superfamily
IG196_RS10630	COG2814	Major facilitator Superfamily
IG196_RS10640	COG0583	DNA-binding transcription factor activity
IG196_RS10650	COG0741	lytic transglycosylase activity
IG196_RS10695	COG0765	amino acid transport
IG196_RS10700	COG0765	amino acid transport
IG196_RS10705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_RS10710	COG1126	abc transporter atp-binding protein
IG196_RS10720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG196_RS10730	COG1609	Transcriptional regulator
IG196_RS10740	COG2197	response regulator
IG196_RS10745	COG2957	Belongs to the agmatine deiminase family
IG196_RS10750	COG2957	Belongs to the agmatine deiminase family
IG196_RS10755	COG0583	DNA-binding transcription factor activity
IG196_RS10760	COG5002	protein histidine kinase activity
IG196_RS10775	COG1024	Enoyl-CoA hydratase
IG196_RS10790	COG1960	acyl-CoA dehydrogenase activity
IG196_RS10795	COG1960	acyl-CoA dehydrogenase activity
IG196_RS10810	COG2271	Major facilitator Superfamily
IG196_RS10840	COG2197	response regulator
IG196_RS10845	COG4585	Histidine kinase
IG196_RS10890	COG2308	Evidence 4 Homologs of previously reported genes of
IG196_RS10915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IG196_RS10930	COG3842	ATPase activity
IG196_RS10945	COG0395	ABC-type sugar transport system, permease component
IG196_RS10965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG196_RS10980	COG1131	(ABC) transporter
IG196_RS11010	COG2951	lytic endotransglycosylase activity
IG196_RS11025	COG0714	Associated with various cellular activities
IG196_RS11035	COG1196	nuclear chromosome segregation
IG196_RS11035	COG3264	Mechanosensitive ion channel
IG196_RS11050	COG1960	acyl-CoA dehydrogenase activity
IG196_RS11065	COG4988	ABC transporter
IG196_RS11070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IG196_RS11075	COG1271	oxidase subunit
IG196_RS11080	COG1294	oxidase, subunit
IG196_RS11105	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS11115	COG2030	dehydratase
IG196_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS11130	COG1024	Enoyl-CoA hydratase
IG196_RS11145	COG0640	Transcriptional regulator
IG196_RS11160	COG3795	YCII-related domain
IG196_RS11165	COG3795	YCII-related domain
IG196_RS11170	COG0477	Major facilitator Superfamily
IG196_RS11180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IG196_RS11190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IG196_RS11200	COG2985	domain, Protein
IG196_RS11205	COG2985	domain, Protein
IG196_RS11255	COG0642	Histidine kinase
IG196_RS11260	COG0745	RESPONSE REGULATOR receiver
IG196_RS11270	COG1414	Transcriptional regulator
IG196_RS11275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG196_RS11280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG196_RS11295	COG2814	Major facilitator Superfamily
IG196_RS11305	COG1082	Xylose isomerase domain protein TIM barrel
IG196_RS11305	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IG196_RS11310	COG0477	Major facilitator Superfamily
IG196_RS11335	COG3148	PFAM DTW domain containing protein
IG196_RS11360	COG1473	amidohydrolase
IG196_RS11410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IG196_RS11435	COG1309	transcriptional regulator
IG196_RS11455	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG196_RS11455	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG196_RS11460	COG0509	glycine decarboxylation via glycine cleavage system
IG196_RS11465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG196_RS11490	COG2207	Transcriptional regulator
IG196_RS11495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_RS11495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_RS11505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS11510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG196_RS11525	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS11535	COG0824	Thioesterase
IG196_RS11540	COG0642	Histidine kinase
IG196_RS11545	COG0745	RESPONSE REGULATOR receiver
IG196_RS11555	COG0671	phosphoesterase, PA-phosphatase related
IG196_RS11560	COG2194	sulfuric ester hydrolase activity
IG196_RS11570	COG4302	ethanolamine ammonia-lyase activity
IG196_RS11575	COG4303	Ethanolamine ammonia lyase large subunit
IG196_RS11580	COG0531	amino acid
IG196_RS11585	COG0545	Peptidyl-prolyl cis-trans isomerase
IG196_RS11595	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IG196_RS11605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IG196_RS11635	COG3284	Transcriptional regulator
IG196_RS11640	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS11700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS11705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_RS11715	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS11725	COG0456	acetyltransferase
IG196_RS11745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS11775	COG1024	Enoyl-CoA hydratase
IG196_RS11790	COG0583	DNA-binding transcription factor activity
IG196_RS11795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IG196_RS11810	COG2818	Glycosylase
IG196_RS11815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG196_RS11845	COG1183	phosphatidylcholine synthase activity
IG196_RS11850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IG196_RS11850	COG0519	Catalyzes the synthesis of GMP from XMP
IG196_RS11855	COG0583	DNA-binding transcription factor activity
IG196_RS11860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS11865	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS11880	COG0640	Transcriptional regulator
IG196_RS11890	COG0583	DNA-binding transcription factor activity
IG196_RS11895	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS11900	COG1960	acyl-CoA dehydrogenase activity
IG196_RS11910	COG1272	protein, Hemolysin III
IG196_RS11915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS11925	COG1024	Enoyl-CoA hydratase
IG196_RS11930	COG1160	GTP binding
IG196_RS11970	COG0583	DNA-binding transcription factor activity
IG196_RS11975	COG3384	dioxygenase
IG196_RS11995	COG0583	DNA-binding transcription factor activity
IG196_RS12020	COG0587	DNA-directed DNA polymerase activity
IG196_RS12050	COG0583	DNA-binding transcription factor activity
IG196_RS12100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG196_RS12105	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IG196_RS12110	COG2080	2 iron, 2 sulfur cluster binding
IG196_RS12135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG196_RS12140	COG0366	Alpha amylase catalytic
IG196_RS12145	COG0366	Alpha amylase catalytic
IG196_RS12160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG196_RS12165	COG1640	4-alpha-glucanotransferase
IG196_RS12175	COG0517	IMP dehydrogenase activity
IG196_RS12210	COG2267	carboxylic ester hydrolase activity
IG196_RS12230	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS12275	COG0583	DNA-binding transcription factor activity
IG196_RS12315	COG0154	amidase activity
IG196_RS12330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IG196_RS12335	COG2271	Major facilitator Superfamily
IG196_RS12365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IG196_RS12370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IG196_RS12380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_RS12385	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS12405	COG1414	Transcriptional regulator
IG196_RS12410	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS12415	COG0028	Belongs to the TPP enzyme family
IG196_RS12420	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IG196_RS12425	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS12465	COG2271	Major facilitator Superfamily
IG196_RS12500	COG0583	DNA-binding transcription factor activity
IG196_RS12510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_RS12520	COG3437	response regulator, receiver
IG196_RS12525	COG0784	Response regulator, receiver
IG196_RS12525	COG2198	Histidine kinase
IG196_RS12525	COG2205	protein histidine kinase activity
IG196_RS12545	COG3842	ATPase activity
IG196_RS12585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG196_RS12590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG196_RS12610	COG3976	FMN-binding domain protein
IG196_RS12610	COG0431	NADPH-dependent FMN reductase
IG196_RS12610	COG1053	succinate dehydrogenase
IG196_RS12635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_RS12655	COG0583	DNA-binding transcription factor activity
IG196_RS12660	COG0477	Major facilitator Superfamily
IG196_RS12665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IG196_RS12695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IG196_RS12700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG196_RS12705	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IG196_RS12705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_RS12715	COG1741	Belongs to the pirin family
IG196_RS12720	COG2259	Doxx family
IG196_RS12730	COG1741	Belongs to the pirin family
IG196_RS12735	COG1054	Belongs to the UPF0176 family
IG196_RS12750	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IG196_RS12750	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IG196_RS12765	COG0848	biopolymer transport protein
IG196_RS12775	COG0824	Thioesterase
IG196_RS12780	COG0436	Aminotransferase
IG196_RS12785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG196_RS12790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IG196_RS12805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IG196_RS12805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IG196_RS12810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IG196_RS12815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG196_RS12820	COG0741	lytic transglycosylase activity
IG196_RS12845	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG196_RS12850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IG196_RS12865	COG0215	cysteine-tRNA ligase activity
IG196_RS12875	COG0825	malonyl-CoA metabolic process
IG196_RS12880	COG0037	tRNA processing
IG196_RS12885	COG0527	aspartate kinase activity
IG196_RS12925	COG4585	Histidine kinase
IG196_RS12950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_RS12985	COG2207	Transcriptional regulator
IG196_RS13005	COG2326	polyphosphate kinase activity
IG196_RS13015	COG0642	Histidine kinase
IG196_RS13025	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS13045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_RS13080	COG0411	ABC transporter
IG196_RS13110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IG196_RS13115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IG196_RS13120	COG1011	Hydrolase
IG196_RS13130	COG1280	lysine exporter protein (LysE YggA)
IG196_RS13140	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IG196_RS13145	COG1562	ergosterol biosynthetic process
IG196_RS13155	COG3158	transport of potassium into the cell
IG196_RS13160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_RS13175	COG0544	peptidyl-prolyl cis-trans isomerase activity
IG196_RS13180	COG0740	serine-type endopeptidase activity
IG196_RS13185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IG196_RS13190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IG196_RS13240	COG2113	Glycine betaine
IG196_RS13245	COG4176	ABC-type proline glycine betaine transport system permease component
IG196_RS13250	COG4175	Glycine betaine
IG196_RS13255	COG0114	fumarate hydratase activity
IG196_RS13260	COG2910	NAD(P)H-binding
IG196_RS13265	COG0583	DNA-binding transcription factor activity
IG196_RS13275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG196_RS13285	COG4654	Cytochrome c, class I
IG196_RS13300	COG0129	dihydroxy-acid dehydratase activity
IG196_RS13305	COG0583	DNA-binding transcription factor activity
IG196_RS13310	COG0583	DNA-binding transcription factor activity
IG196_RS13325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IG196_RS13330	COG1802	Transcriptional regulator
IG196_RS13350	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS13365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG196_RS13380	COG0730	response to heat
IG196_RS13400	COG1797	cobyrinic acid a,c-diamide synthase activity
IG196_RS13410	COG4607	ABC-type enterochelin transport system periplasmic component
IG196_RS13415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG196_RS13420	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IG196_RS13425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IG196_RS13430	COG0778	Nitroreductase
IG196_RS13445	COG1429	ligase activity, forming nitrogen-metal bonds
IG196_RS13450	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IG196_RS13455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG196_RS13465	COG1346	cytolysis
IG196_RS13490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_RS13500	COG1538	Outer membrane efflux protein
IG196_RS13520	COG1492	cobalamin metabolic process
IG196_RS13525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IG196_RS13530	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IG196_RS13545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IG196_RS13550	COG3550	peptidyl-serine autophosphorylation
IG196_RS13560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_RS13580	COG0560	Phosphoserine phosphatase
IG196_RS13585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IG196_RS13590	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IG196_RS13590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IG196_RS13595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IG196_RS13595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IG196_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS13630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IG196_RS13645	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
IG196_RS13650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IG196_RS13665	COG0557	exoribonuclease II activity
IG196_RS13670	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS13675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IG196_RS13675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IG196_RS13695	COG0052	Belongs to the universal ribosomal protein uS2 family
IG196_RS13700	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IG196_RS13705	COG0528	UMP kinase activity
IG196_RS13710	COG0233	cytoplasmic translational termination
IG196_RS13715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IG196_RS13720	COG0575	Belongs to the CDS family
IG196_RS13725	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IG196_RS13730	COG0750	zinc metalloprotease
IG196_RS13735	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG196_RS13745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG196_RS13750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG196_RS13755	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG196_RS13760	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG196_RS13770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IG196_RS13775	COG0505	Belongs to the CarA family
IG196_RS13780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IG196_RS13790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG196_RS13805	COG1534	Rna-binding protein
IG196_RS13810	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IG196_RS13815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG196_RS13825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG196_RS13845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_RS13850	COG1024	Enoyl-CoA hydratase
IG196_RS13855	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_RS13865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG196_RS13875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IG196_RS13880	COG0252	asparaginase activity
IG196_RS13885	COG0563	adenylate kinase activity
IG196_RS13890	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IG196_RS13895	COG2835	tetraacyldisaccharide 4'-kinase activity
IG196_RS13900	COG1663	tetraacyldisaccharide 4'-kinase activity
IG196_RS13905	COG0848	biopolymer transport protein
IG196_RS13910	COG0811	peptide transport
IG196_RS13915	COG1570	exodeoxyribonuclease VII activity
IG196_RS13970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IG196_RS13975	COG0542	response to heat
IG196_RS13980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_RS13985	COG2925	Exonuclease
IG196_RS14010	COG4191	Histidine kinase
IG196_RS14015	COG4566	intracellular signal transduction
IG196_RS14030	COG2808	Putative FMN-binding domain
IG196_RS14045	COG1619	proteins homologs of microcin C7 resistance protein MccF
IG196_RS14075	COG5002	protein histidine kinase activity
IG196_RS14085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IG196_RS14090	COG4999	Histidine kinase
IG196_RS14090	COG2205	protein histidine kinase activity
IG196_RS14090	COG3437	response regulator, receiver
IG196_RS14090	COG3850	Histidine kinase
IG196_RS14120	COG0156	8-amino-7-oxononanoate synthase activity
IG196_RS14125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IG196_RS14130	COG0667	Aldo Keto reductase
IG196_RS14135	COG2207	Transcriptional regulator
IG196_RS14140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_RS14145	COG3360	Dodecin
IG196_RS14155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_RS14160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_RS14165	COG1473	amidohydrolase
IG196_RS14175	COG1126	abc transporter atp-binding protein
IG196_RS14180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_RS14190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_RS14210	COG0601	transmembrane transport
IG196_RS14215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_RS14240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IG196_RS14240	COG1042	CoA-binding domain protein
IG196_RS14240	COG0045	succinate-CoA ligase (ADP-forming) activity
IG196_RS14250	COG2258	MOSC domain
IG196_RS14265	COG2207	Transcriptional regulator
IG196_RS14270	COG1473	amidohydrolase
IG196_RS14275	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS14285	COG0583	DNA-binding transcription factor activity
IG196_RS14300	COG2351	hydroxyisourate hydrolase activity
IG196_RS14305	COG2351	hydroxyisourate hydrolase activity
IG196_RS14310	COG0590	tRNA wobble adenosine to inosine editing
IG196_RS14320	COG0251	oxidation-reduction process
IG196_RS14325	COG2801	Transposase and inactivated derivatives
IG196_RS14335	COG0666	response to abiotic stimulus
IG196_RS14340	COG0084	hydrolase, TatD family'
IG196_RS14355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IG196_RS14360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IG196_RS14435	COG2183	response to ionizing radiation
IG196_RS14440	COG4585	Histidine kinase
IG196_RS14445	COG2201	protein-glutamate methylesterase activity
IG196_RS14485	COG0534	Mate efflux family protein
IG196_RS14500	COG4774	siderophore transport
IG196_RS14505	COG3712	iron ion homeostasis
IG196_RS14510	COG1595	DNA-templated transcription, initiation
IG196_RS14525	COG0477	Major facilitator Superfamily
IG196_RS14535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IG196_RS14535	COG3008	intermembrane lipid transfer
IG196_RS14540	COG2995	paraquat-inducible protein a
IG196_RS14545	COG2995	paraquat-inducible protein a
IG196_RS14550	COG2814	Major facilitator Superfamily
IG196_RS14555	COG2814	Major facilitator Superfamily
IG196_RS14570	COG0583	DNA-binding transcription factor activity
IG196_RS14580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IG196_RS14615	COG0247	lactate metabolic process
IG196_RS14615	COG0277	FAD linked oxidase domain protein
IG196_RS14620	COG1802	Transcriptional regulator
IG196_RS14640	COG0583	DNA-binding transcription factor activity
IG196_RS14645	COG2814	Major facilitator Superfamily
IG196_RS14665	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IG196_RS14670	COG0583	DNA-binding transcription factor activity
IG196_RS14690	COG1960	acyl-CoA dehydrogenase activity
IG196_RS14695	COG2130	NADP-dependent
IG196_RS14725	COG1960	acyl-CoA dehydrogenase activity
IG196_RS14735	COG0183	Belongs to the thiolase family
IG196_RS14745	COG1024	Enoyl-CoA hydratase
IG196_RS14745	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_RS14755	COG0411	ABC transporter
IG196_RS14765	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_RS14780	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS14785	COG2272	Belongs to the type-B carboxylesterase lipase family
IG196_RS14795	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IG196_RS14800	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG196_RS14805	COG2917	probably involved in intracellular septation
IG196_RS14815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IG196_RS14840	COG0047	phosphoribosylformylglycinamidine synthase activity
IG196_RS14840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IG196_RS14845	COG0024	Methionine aminopeptidase
IG196_RS14850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IG196_RS14875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG196_RS14880	COG0765	amino acid transport
IG196_RS14885	COG4597	amino acid ABC transporter
IG196_RS14890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_RS14900	COG0242	peptide deformylase activity
IG196_RS14910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IG196_RS14920	COG1196	nuclear chromosome segregation
IG196_RS14935	COG3550	peptidyl-serine autophosphorylation
IG196_RS14985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG196_RS15000	COG0433	COG0433 Predicted ATPase
IG196_RS15010	COG1595	DNA-templated transcription, initiation
IG196_RS15035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IG196_RS15040	COG1744	ABC transporter substrate-binding protein PnrA-like
IG196_RS15050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IG196_RS15060	COG3845	ABC transporter
IG196_RS15065	COG4603	Belongs to the binding-protein-dependent transport system permease family
IG196_RS15070	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG196_RS15080	COG0402	S-adenosylhomocysteine deaminase activity
IG196_RS15100	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS15140	COG0519	Catalyzes the synthesis of GMP from XMP
IG196_RS15140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IG196_RS15170	COG2867	negative regulation of translational initiation
IG196_RS15175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IG196_RS15210	COG1217	gtp-binding protein TYPA
IG196_RS15215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IG196_RS15220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IG196_RS15225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IG196_RS15230	COG2251	uridine kinase activity
IG196_RS15230	COG0195	Participates in both transcription termination and antitermination
IG196_RS15235	COG0779	Required for maturation of 30S ribosomal subunits
IG196_RS15240	COG0477	Major facilitator Superfamily
IG196_RS15245	COG4172	Belongs to the ABC transporter superfamily
IG196_RS15250	COG4239	(ABC) transporter, permease
IG196_RS15255	COG4174	ABC transporter (Permease)
IG196_RS15260	COG4166	transmembrane transport
IG196_RS15270	COG1793	dna ligase
IG196_RS15335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IG196_RS15355	COG0583	DNA-binding transcription factor activity
IG196_RS15360	COG0436	Aminotransferase
IG196_RS15380	COG1643	Atp-dependent helicase
IG196_RS15385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG196_RS15390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IG196_RS15390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IG196_RS15395	COG1280	lysine exporter protein (LysE YggA)
IG196_RS15410	COG2171	N-acyltransferase activity
IG196_RS15420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG196_RS15425	COG2890	protein-(glutamine-N5) methyltransferase activity
IG196_RS15430	COG0488	(ABC) transporter
IG196_RS15460	COG1228	amidohydrolase
IG196_RS15480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IG196_RS15495	COG0823	Involved in the tonB-independent uptake of proteins
IG196_RS15500	COG1132	(ABC) transporter
IG196_RS15505	COG1802	Transcriptional regulator
IG196_RS15510	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS15515	COG3246	L-lysine catabolic process to acetate
IG196_RS15525	COG1530	ribonuclease E activity
IG196_RS15530	COG0424	maF-like protein
IG196_RS15535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IG196_RS15540	COG0799	negative regulation of ribosome biogenesis
IG196_RS15545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IG196_RS15550	COG0408	coproporphyrinogen oxidase activity
IG196_RS15555	COG0151	Belongs to the GarS family
IG196_RS15560	COG0217	transcriptional regulatory protein
IG196_RS15565	COG2226	methyltransferase
IG196_RS15590	COG1538	Outer membrane efflux protein
IG196_RS15600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_RS15605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IG196_RS15610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IG196_RS15615	COG4208	sulfate ABC transporter
IG196_RS15625	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IG196_RS15635	COG0450	alkyl hydroperoxide reductase
IG196_RS15645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IG196_RS15650	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS15670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IG196_RS15690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IG196_RS15695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_RS15705	COG1045	serine acetyltransferase
IG196_RS15725	COG0778	Nitroreductase
IG196_RS15735	COG1116	anion transmembrane transporter activity
IG196_RS15740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_RS15745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS15750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG196_RS15755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_RS15760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_RS15765	COG0431	NADPH-dependent FMN reductase
IG196_RS15775	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IG196_RS15780	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IG196_RS15780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_RS15790	COG0584	glycerophosphoryl diester phosphodiesterase
IG196_RS15800	COG5002	protein histidine kinase activity
IG196_RS15805	COG0745	RESPONSE REGULATOR receiver
IG196_RS15810	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
IG196_RS15815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IG196_RS15825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG196_RS15830	COG0427	acetyl-CoA hydrolase
IG196_RS15835	COG0583	DNA-binding transcription factor activity
IG196_RS15840	COG0251	oxidation-reduction process
IG196_RS15850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_RS15855	COG0583	DNA-binding transcription factor activity
IG196_RS15860	COG0667	Aldo Keto reductase
IG196_RS15880	COG0789	Transcriptional regulator
IG196_RS15890	COG2382	esterase
IG196_RS15900	COG1446	asparaginase
IG196_RS15905	COG4172	Belongs to the ABC transporter superfamily
IG196_RS15910	COG0747	negative chemotaxis
IG196_RS15915	COG0601	transmembrane transport
IG196_RS15920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_RS15935	COG4191	Histidine kinase
IG196_RS15935	COG0745	RESPONSE REGULATOR receiver
IG196_RS15935	COG2205	protein histidine kinase activity
IG196_RS15970	COG0529	Catalyzes the synthesis of activated sulfate
IG196_RS15970	COG2895	sulfate adenylyltransferase (ATP) activity
IG196_RS15975	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IG196_RS15980	COG0492	ferredoxin-NADP+ reductase activity
IG196_RS16015	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IG196_RS16035	COG0351	phosphomethylpyrimidine kinase
IG196_RS16050	COG2022	thiamine diphosphate biosynthetic process
IG196_RS16125	COG0154	amidase activity
IG196_RS16145	COG2267	carboxylic ester hydrolase activity
IG196_RS16175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_RS16180	COG0642	Histidine kinase
IG196_RS16190	COG1414	Transcriptional regulator
IG196_RS16210	COG2207	Transcriptional regulator
IG196_RS16210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IG196_RS16220	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IG196_RS16225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IG196_RS16230	COG1414	Transcriptional regulator
IG196_RS16240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_RS16245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG196_RS16250	COG1183	phosphatidylcholine synthase activity
IG196_RS16255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IG196_RS16260	COG0440	acetolactate synthase activity
IG196_RS16265	COG0028	Belongs to the TPP enzyme family
IG196_RS16290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IG196_RS16345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_RS16405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_RS16415	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS16435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IG196_RS16440	COG0746	molybdenum cofactor guanylyltransferase activity
IG196_RS16450	COG0328	RNA-DNA hybrid ribonuclease activity
IG196_RS16455	COG2226	methyltransferase
IG196_RS16460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG196_RS16465	COG0741	lytic transglycosylase activity
IG196_RS16465	COG1388	LysM domain
IG196_RS16470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IG196_RS16470	COG0475	glutathione-regulated potassium exporter activity
IG196_RS16475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS16485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_RS16495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IG196_RS16500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IG196_RS16505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IG196_RS16525	COG1074	ATP-dependent DNA helicase activity
IG196_RS16540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IG196_RS16545	COG0673	inositol 2-dehydrogenase activity
IG196_RS16550	COG0254	rRNA binding
IG196_RS16560	COG0534	Mate efflux family protein
IG196_RS16580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IG196_RS16585	COG0581	inorganic phosphate transmembrane transporter activity
IG196_RS16590	COG0573	inorganic phosphate transmembrane transporter activity
IG196_RS16595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IG196_RS16600	COG0248	Ppx GppA phosphatase
IG196_RS16615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IG196_RS16625	COG0492	ferredoxin-NADP+ reductase activity
IG196_RS16635	COG0625	glutathione transferase activity
IG196_RS16655	COG0582	viral genome integration into host DNA
IG196_RS17025	COG0582	viral genome integration into host DNA
IG196_RS17070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_RS17075	COG0589	response to stress
IG196_RS17085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_RS17110	COG0589	response to stress
IG196_RS17120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IG196_RS17125	COG3932	Exopolysaccharide synthesis, ExoD
IG196_RS17160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_RS17180	COG1063	alcohol dehydrogenase
IG196_RS17225	COG0589	response to stress
IG196_RS17255	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IG196_RS17265	COG4191	Histidine kinase
IG196_RS17265	COG0784	Response regulator, receiver
IG196_RS17285	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS17295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IG196_RS17330	COG0642	Histidine kinase
IG196_RS17350	COG1022	Amp-dependent synthetase and ligase
IG196_RS17365	COG2814	Major facilitator Superfamily
IG196_RS17370	COG1309	transcriptional regulator
IG196_RS17375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_RS17380	COG1132	(ABC) transporter
IG196_RS17535	COG1024	Enoyl-CoA hydratase
IG196_RS17555	COG1522	sequence-specific DNA binding
IG196_RS17560	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS17600	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS17620	COG1295	ribonuclease BN
IG196_RS17630	COG2059	Chromate
IG196_RS17635	COG0667	Aldo Keto reductase
IG196_RS17655	COG0644	oxidoreductase
IG196_RS17660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IG196_RS17675	COG4181	ATPase activity
IG196_RS17695	COG0626	cystathionine gamma-synthase activity
IG196_RS17700	COG0501	Belongs to the peptidase M48B family
IG196_RS17720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IG196_RS17725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IG196_RS17735	COG0330	HflC and HflK could
IG196_RS17740	COG0330	HflC and HflK could
IG196_RS17745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IG196_RS17750	COG1923	regulation of RNA biosynthetic process
IG196_RS17755	COG1160	GTP binding
IG196_RS17760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG196_RS17770	COG0124	histidyl-tRNA synthetase
IG196_RS17775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IG196_RS17790	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IG196_RS17795	COG0105	UTP biosynthetic process
IG196_RS17800	COG1187	pseudouridine synthase activity
IG196_RS17805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IG196_RS17810	COG0564	pseudouridine synthase activity
IG196_RS17820	COG1199	ATP-dependent helicase activity
IG196_RS17840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IG196_RS17845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG196_RS17850	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG196_RS17855	COG0567	Dehydrogenase, E1 component
IG196_RS17875	COG2368	4-hydroxyphenylacetate
IG196_RS17885	COG2133	pyrroloquinoline quinone binding
IG196_RS17890	COG0791	NLP P60 protein
IG196_RS17900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG196_RS17910	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG196_RS17915	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IG196_RS17925	COG4566	intracellular signal transduction
IG196_RS17930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IG196_RS17945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IG196_RS17950	COG0167	dihydroorotate dehydrogenase activity
IG196_RS17965	COG0579	oxidoreductase
IG196_RS18000	COG1596	polysaccharide export
IG196_RS18005	COG0489	protein tyrosine kinase activity
IG196_RS18005	COG3206	protein involved in exopolysaccharide biosynthesis
IG196_RS18010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IG196_RS18015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG196_RS18045	COG0297	glycogen (starch) synthase activity
IG196_RS18050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IG196_RS18055	COG2197	response regulator
IG196_RS18065	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IG196_RS18085	COG0443	Heat shock 70 kDa protein
IG196_RS18100	COG0822	iron-sulfur transferase activity
IG196_RS18105	COG1104	cysteine desulfurase activity
IG196_RS18110	COG1959	2 iron, 2 sulfur cluster binding
IG196_RS18115	COG0556	nucleotide-excision repair
IG196_RS18130	COG2878	Part of a membrane complex involved in electron transport
IG196_RS18140	COG0697	spore germination
IG196_RS18145	COG1522	sequence-specific DNA binding
IG196_RS18155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IG196_RS18160	COG4770	biotin carboxylase activity
IG196_RS18165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG196_RS18170	COG1703	isobutyryl-CoA mutase activity
IG196_RS18180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_RS18180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_RS18185	COG1802	Transcriptional regulator
IG196_RS18195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IG196_RS18215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IG196_RS18225	COG1802	Transcriptional regulator
IG196_RS18230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG196_RS18240	COG4166	transmembrane transport
IG196_RS18255	COG4172	Belongs to the ABC transporter superfamily
IG196_RS18265	COG2808	Putative FMN-binding domain
IG196_RS18280	COG0028	Belongs to the TPP enzyme family
IG196_RS18310	COG3813	Protein conserved in bacteria
IG196_RS18325	COG0346	lactoylglutathione lyase activity
IG196_RS18350	COG1595	DNA-templated transcription, initiation
IG196_RS18355	COG3712	iron ion homeostasis
IG196_RS18395	COG1733	regulation of RNA biosynthetic process
IG196_RS18410	COG0583	DNA-binding transcription factor activity
IG196_RS18415	COG2249	NAD(P)H dehydrogenase (quinone) activity
IG196_RS18430	COG2076	Multidrug Resistance protein
IG196_RS18465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IG196_RS18515	COG4774	siderophore transport
IG196_RS18530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IG196_RS18530	COG4651	solute:proton antiporter activity
IG196_RS18535	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IG196_RS18540	COG1301	dicarboxylic acid transport
IG196_RS18545	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS18555	COG1546	Belongs to the CinA family
IG196_RS18555	COG1058	Belongs to the CinA family
IG196_RS18575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS18580	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IG196_RS18590	COG0583	DNA-binding transcription factor activity
IG196_RS18600	COG0183	Belongs to the thiolase family
IG196_RS18605	COG3243	poly(R)-hydroxyalkanoic acid synthase
IG196_RS18640	COG3045	CreA protein
IG196_RS18650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_RS18660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_RS18710	COG1742	UPF0060 membrane protein
IG196_RS18725	COG1360	Flagellar Motor Protein
IG196_RS18795	COG0387	Pfam Sodium calcium exchanger
IG196_RS18805	COG2197	response regulator
IG196_RS18860	COG4964	Belongs to the GSP D family
IG196_RS18880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS18885	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS18920	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS18930	COG2814	Major facilitator Superfamily
IG196_RS18950	COG0604	alcohol dehydrogenase
IG196_RS18960	COG3321	synthase
IG196_RS18960	COG0604	alcohol dehydrogenase
IG196_RS18965	COG0583	DNA-binding transcription factor activity
IG196_RS18970	COG4948	Mandelate Racemase Muconate Lactonizing
IG196_RS18980	COG0583	DNA-binding transcription factor activity
IG196_RS18985	COG1902	pentaerythritol trinitrate reductase activity
IG196_RS18995	COG1595	DNA-templated transcription, initiation
IG196_RS19025	COG2197	response regulator
IG196_RS19045	COG0006	proline dipeptidase activity
IG196_RS19050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IG196_RS19060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG196_RS19065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG196_RS19070	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS19090	COG1522	sequence-specific DNA binding
IG196_RS19105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IG196_RS19115	COG0275	rRNA processing
IG196_RS19185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG196_RS19215	COG0392	lysyltransferase activity
IG196_RS19220	COG5002	protein histidine kinase activity
IG196_RS19225	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IG196_RS19235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IG196_RS19265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IG196_RS19270	COG0417	DNA replication proofreading
IG196_RS19310	COG0402	S-adenosylhomocysteine deaminase activity
IG196_RS19330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS19350	COG1024	Enoyl-CoA hydratase
IG196_RS19355	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS19360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS19370	COG0583	DNA-binding transcription factor activity
IG196_RS19400	COG0730	response to heat
IG196_RS19405	COG0402	S-adenosylhomocysteine deaminase activity
IG196_RS19425	COG2894	cell division
IG196_RS19430	COG1215	transferase activity, transferring glycosyl groups
IG196_RS19435	COG1215	transferase activity, transferring glycosyl groups
IG196_RS19440	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IG196_RS19445	COG0457	Tetratricopeptide repeat
IG196_RS19480	COG3436	PFAM IS66 Orf2 family protein
IG196_RS19485	COG4372	Transposase
IG196_RS19510	COG0776	regulation of translation
IG196_RS19515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IG196_RS19515	COG0072	phenylalanine-tRNA ligase activity
IG196_RS19520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IG196_RS19525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IG196_RS19530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IG196_RS19535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IG196_RS19540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IG196_RS19565	COG2207	Transcriptional regulator
IG196_RS19575	COG0028	Belongs to the TPP enzyme family
IG196_RS19580	COG1309	transcriptional regulator
IG196_RS19590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS19595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_RS19610	COG0673	inositol 2-dehydrogenase activity
IG196_RS19625	COG3214	Protein conserved in bacteria
IG196_RS19630	COG4774	siderophore transport
IG196_RS19635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IG196_RS19650	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IG196_RS19655	COG0802	atpase or kinase
IG196_RS19660	COG0860	N-Acetylmuramoyl-L-alanine amidase
IG196_RS19670	COG2226	methyltransferase
IG196_RS19675	COG0789	Transcriptional regulator
IG196_RS19685	COG0586	Pfam SNARE associated Golgi protein
IG196_RS19695	COG0583	DNA-binding transcription factor activity
IG196_RS19700	COG2271	Major facilitator Superfamily
IG196_RS19705	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG196_RS19710	COG0129	dihydroxy-acid dehydratase activity
IG196_RS19715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IG196_RS19720	COG0477	Major facilitator Superfamily
IG196_RS19750	COG2207	Transcriptional regulator
IG196_RS19755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IG196_RS19760	COG4181	ATPase activity
IG196_RS19780	COG0625	glutathione transferase activity
IG196_RS19790	COG2186	Transcriptional regulator
IG196_RS19805	COG3795	YCII-related domain
IG196_RS19810	COG4941	Belongs to the sigma-70 factor family
IG196_RS19895	COG1566	PFAM secretion protein HlyD family protein
IG196_RS19905	COG1846	Transcriptional regulator
IG196_RS19910	COG1132	(ABC) transporter
IG196_RS19920	COG0494	nUDIX hydrolase
IG196_RS19930	COG1007	ATP synthesis coupled electron transport
IG196_RS19945	COG0713	ATP synthesis coupled electron transport
IG196_RS19955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG196_RS19960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IG196_RS19965	COG1034	ATP synthesis coupled electron transport
IG196_RS19980	COG0649	NAD binding
IG196_RS19985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG196_RS19990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG196_RS19995	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG196_RS20010	COG0149	triose-phosphate isomerase activity
IG196_RS20020	COG1185	polyribonucleotide nucleotidyltransferase activity
IG196_RS20025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IG196_RS20040	COG0436	Aminotransferase
IG196_RS20045	COG0683	leucine binding
IG196_RS20060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IG196_RS20065	COG3707	response regulator
IG196_RS20070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_RS20075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS20080	COG1116	anion transmembrane transporter activity
IG196_RS20090	COG2223	nitrite transmembrane transporter activity
IG196_RS20100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG196_RS20115	COG0243	molybdopterin cofactor binding
IG196_RS20120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IG196_RS20135	COG0791	NLP P60 protein
IG196_RS20140	COG2081	HI0933 family
IG196_RS20145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IG196_RS20155	COG0494	nUDIX hydrolase
IG196_RS20170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG196_RS20175	COG0385	Bile acid
IG196_RS20180	COG2072	flavoprotein involved in K transport
IG196_RS20185	COG0300	oxidoreductase activity
IG196_RS20190	COG1063	alcohol dehydrogenase
IG196_RS20195	COG3842	ATPase activity
IG196_RS20200	COG0395	ABC-type sugar transport system, permease component
IG196_RS20205	COG1175	transmembrane transport
IG196_RS20210	COG1653	transport
IG196_RS20220	COG0312	modulator of DNA gyrase
IG196_RS20230	COG0521	Mo-molybdopterin cofactor biosynthetic process
IG196_RS20270	COG2205	protein histidine kinase activity
IG196_RS20275	COG0475	glutathione-regulated potassium exporter activity
IG196_RS20300	COG0789	Transcriptional regulator
IG196_RS20310	COG0024	Methionine aminopeptidase
IG196_RS20345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IG196_RS20350	COG1045	serine acetyltransferase
IG196_RS20360	COG0483	inositol monophosphate 1-phosphatase activity
IG196_RS20365	COG1289	transmembrane transporter activity
IG196_RS20380	COG1522	sequence-specific DNA binding
IG196_RS20400	COG2311	Membrane
IG196_RS20410	COG0583	DNA-binding transcription factor activity
IG196_RS20435	COG3119	arylsulfatase activity
IG196_RS20445	COG3039	Transposase
IG196_RS20470	COG2274	protein secretion by the type I secretion system
IG196_RS20490	COG0784	Response regulator, receiver
IG196_RS20490	COG5002	protein histidine kinase activity
IG196_RS20490	COG2205	protein histidine kinase activity
IG196_RS20495	COG1024	Enoyl-CoA hydratase
IG196_RS20500	COG1960	acyl-CoA dehydrogenase activity
IG196_RS20505	COG1960	acyl-CoA dehydrogenase activity
IG196_RS20510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS20530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS20535	COG0583	DNA-binding transcription factor activity
IG196_RS20540	COG1695	Transcriptional regulator
IG196_RS20545	COG2375	cellular response to nickel ion
IG196_RS20550	COG0598	Magnesium transport protein CorA
IG196_RS20570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IG196_RS20590	COG4941	Belongs to the sigma-70 factor family
IG196_RS20595	COG3795	YCII-related domain
IG196_RS20600	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS20610	COG4585	Histidine kinase
IG196_RS20635	COG1968	undecaprenyl-diphosphatase activity
IG196_RS20650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_RS20655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG196_RS20660	COG1737	Transcriptional regulator
IG196_RS20720	COG2972	Histidine kinase
IG196_RS20735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG196_RS20775	COG3177	Filamentation induced by cAMP protein fic
IG196_RS20780	COG0004	ammonium transporteR
IG196_RS20805	COG4774	siderophore transport
IG196_RS20820	COG1131	(ABC) transporter
IG196_RS20825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IG196_RS20835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IG196_RS20865	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS20870	COG2201	protein-glutamate methylesterase activity
IG196_RS20875	COG2918	glutathione biosynthetic process
IG196_RS20900	COG0523	cobalamin synthesis protein
IG196_RS20935	COG0583	DNA-binding transcription factor activity
IG196_RS20940	COG0405	Gamma-glutamyltransferase
IG196_RS20955	COG4774	siderophore transport
IG196_RS20995	COG2354	Protein conserved in bacteria
IG196_RS21010	COG4628	conserved protein (DUF2132)
IG196_RS21025	COG0564	pseudouridine synthase activity
IG196_RS21030	COG0589	response to stress
IG196_RS21050	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IG196_RS21055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IG196_RS21065	COG1252	NADH dehydrogenase
IG196_RS21090	COG3485	protocatechuate 3,4-dioxygenase
IG196_RS21100	COG3246	L-lysine catabolic process to acetate
IG196_RS21135	COG4773	Receptor
IG196_RS21140	COG3712	iron ion homeostasis
IG196_RS21145	COG1595	DNA-templated transcription, initiation
IG196_RS21150	COG0300	oxidoreductase activity
IG196_RS21160	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS21170	COG1764	response to oxidative stress
IG196_RS21190	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS21200	COG2271	Major facilitator Superfamily
IG196_RS21215	COG0765	amino acid transport
IG196_RS21220	COG0765	amino acid transport
IG196_RS21230	COG0583	DNA-binding transcription factor activity
IG196_RS21235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IG196_RS21245	COG0454	-acetyltransferase
IG196_RS21255	COG0584	glycerophosphoryl diester phosphodiesterase
IG196_RS21275	COG2132	Multicopper oxidase
IG196_RS21295	COG3191	aminopeptidase activity
IG196_RS21315	COG0789	Transcriptional regulator
IG196_RS21330	COG0488	(ABC) transporter
IG196_RS21335	COG0513	Belongs to the DEAD box helicase family
IG196_RS21355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS21360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_RS21365	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_RS21370	COG2186	Transcriptional regulator
IG196_RS21375	COG0129	dihydroxy-acid dehydratase activity
IG196_RS21380	COG3734	2-keto-3-deoxy-galactonokinase
IG196_RS21385	COG0800	Aldolase
IG196_RS21390	COG0235	Class ii aldolase
IG196_RS21400	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS21425	COG1840	ABC-type Fe3 transport system, periplasmic component
IG196_RS21435	COG3842	ATPase activity
IG196_RS21450	COG0346	lactoylglutathione lyase activity
IG196_RS21465	COG0800	Aldolase
IG196_RS21475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS21480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG196_RS21485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG196_RS21490	COG3265	gluconokinase activity
IG196_RS21515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG196_RS21520	COG0259	pyridoxamine-phosphate oxidase activity
IG196_RS21550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG196_RS21555	COG1309	transcriptional regulator
IG196_RS21560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IG196_RS21585	COG2169	Transcriptional regulator
IG196_RS21595	COG0697	spore germination
IG196_RS21610	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS21615	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS21620	COG3268	Saccharopine dehydrogenase
IG196_RS21640	COG0625	glutathione transferase activity
IG196_RS21715	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IG196_RS21730	COG1595	DNA-templated transcription, initiation
IG196_RS21775	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS21800	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS21825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IG196_RS21850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG196_RS21875	COG0285	dihydrofolate synthase activity
IG196_RS21880	COG1393	Belongs to the ArsC family
IG196_RS21890	COG3123	guanosine phosphorylase activity
IG196_RS21895	COG0137	argininosuccinate synthase activity
IG196_RS21905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IG196_RS21910	COG1666	GTP binding
IG196_RS21920	COG0251	oxidation-reduction process
IG196_RS21925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IG196_RS21930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IG196_RS21935	COG0667	Aldo Keto reductase
IG196_RS21940	COG2267	carboxylic ester hydrolase activity
IG196_RS21950	COG1464	Belongs to the NlpA lipoprotein family
IG196_RS21965	COG1464	Belongs to the NlpA lipoprotein family
IG196_RS21970	COG2011	ABC-type metal ion transport system permease component
IG196_RS21980	COG1464	Belongs to the NlpA lipoprotein family
IG196_RS21995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG196_RS22000	COG0308	aminopeptidase N
IG196_RS22005	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IG196_RS22015	COG1403	HNH endonuclease
IG196_RS22120	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IG196_RS22125	COG4638	Rieske (2fe-2S)
IG196_RS22140	COG0683	leucine binding
IG196_RS22150	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IG196_RS22205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG196_RS22210	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_RS22220	COG0513	Belongs to the DEAD box helicase family
IG196_RS22225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IG196_RS22235	COG2154	pterin-4-alpha-carbinolamine dehydratase
IG196_RS22240	COG1162	GTPase activity
IG196_RS22250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG196_RS22255	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IG196_RS22260	COG0494	nUDIX hydrolase
IG196_RS22265	COG0335	large ribosomal subunit rRNA binding
IG196_RS22270	COG0336	Belongs to the RNA methyltransferase TrmD family
IG196_RS22275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IG196_RS22280	COG0228	four-way junction DNA binding
IG196_RS22295	COG0306	phosphate transporter
IG196_RS22300	COG1392	Phosphate transport regulator
IG196_RS22315	COG0617	tRNA 3'-terminal CCA addition
IG196_RS22320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IG196_RS22325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IG196_RS22345	COG1917	Cupin 2, conserved barrel domain protein
IG196_RS22345	COG4977	sequence-specific DNA binding
IG196_RS22350	COG4941	Belongs to the sigma-70 factor family
IG196_RS22360	COG3795	YCII-related domain
IG196_RS22380	COG0728	peptidoglycan biosynthetic process
IG196_RS22385	COG0268	Binds directly to 16S ribosomal RNA
IG196_RS22395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IG196_RS22400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IG196_RS22410	COG0727	PFAM Uncharacterised protein family (UPF0153)
IG196_RS22415	COG1522	sequence-specific DNA binding
IG196_RS22420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IG196_RS22430	COG3483	tryptophan 2,3-dioxygenase activity
IG196_RS22440	COG0583	DNA-binding transcription factor activity
IG196_RS22445	COG3960	tartronate-semialdehyde synthase activity
IG196_RS22450	COG3622	Belongs to the hyi family
IG196_RS22455	COG2084	Dehydrogenase
IG196_RS22485	COG1414	Transcriptional regulator
IG196_RS22490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG196_RS22505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS22515	COG1116	anion transmembrane transporter activity
IG196_RS22520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS22550	COG0745	RESPONSE REGULATOR receiver
IG196_RS22565	COG0642	Histidine kinase
IG196_RS22575	COG2267	carboxylic ester hydrolase activity
IG196_RS22585	COG1733	regulation of RNA biosynthetic process
IG196_RS22605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_RS22615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_RS22625	COG0829	nickel cation binding
IG196_RS22630	COG0583	DNA-binding transcription factor activity
IG196_RS22665	COG2855	membrane
IG196_RS22675	COG2879	small protein
IG196_RS22680	COG1966	Carbon starvation protein
IG196_RS22710	COG4969	Belongs to the N-Me-Phe pilin family
IG196_RS22730	COG0791	NLP P60 protein
IG196_RS22745	COG1106	Psort location Cytoplasmic, score
IG196_RS22790	COG0667	Aldo Keto reductase
IG196_RS22795	COG3540	Alkaline phosphatase
IG196_RS22805	COG2814	Major facilitator Superfamily
IG196_RS22825	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_RS22845	COG0477	Major facilitator Superfamily
IG196_RS22865	COG0613	PHP domain protein
IG196_RS22875	COG0009	L-threonylcarbamoyladenylate synthase
IG196_RS22880	COG1994	Peptidase M50
IG196_RS22885	COG0180	Tryptophanyl-tRNA synthetase
IG196_RS22890	COG2197	response regulator
IG196_RS22895	COG2205	protein histidine kinase activity
IG196_RS22895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_RS22900	COG1950	PFAM Membrane protein of
IG196_RS22910	COG0583	DNA-binding transcription factor activity
IG196_RS22915	COG1473	amidohydrolase
IG196_RS22920	COG0583	DNA-binding transcription factor activity
IG196_RS22930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG196_RS22970	COG1191	sigma factor activity
IG196_RS22985	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IG196_RS23010	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IG196_RS23015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IG196_RS23020	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IG196_RS23025	COG0643	Histidine kinase
IG196_RS23025	COG2198	Histidine kinase
IG196_RS23050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IG196_RS23070	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IG196_RS23075	COG1334	flagellar protein FlaG
IG196_RS23085	COG1677	Flagellar hook-basal body complex protein FliE
IG196_RS23120	COG1580	Controls the rotational direction of flagella during chemotaxis
IG196_RS23130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IG196_RS23145	COG1987	bacterial-type flagellum assembly
IG196_RS23170	COG3275	phosphorelay sensor kinase activity
IG196_RS23175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG196_RS23185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IG196_RS23235	COG1256	bacterial-type flagellum assembly
IG196_RS23245	COG0835	chemotaxis
IG196_RS23250	COG0840	transmembrane signaling receptor activity
IG196_RS23265	COG0840	transmembrane signaling receptor activity
IG196_RS23270	COG1705	Flagellar rod assembly protein muramidase FlgJ
IG196_RS23270	COG3951	Flagellar rod assembly protein muramidase FlgJ
IG196_RS23275	COG1706	bacterial-type flagellum-dependent cell motility
IG196_RS23280	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IG196_RS23305	COG1558	bacterial-type flagellum-dependent cell motility
IG196_RS23310	COG1815	bacterial-type flagellum-dependent cell motility
IG196_RS23340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG196_RS23345	COG0235	Class ii aldolase
IG196_RS23350	COG0625	glutathione transferase activity
IG196_RS23355	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS23360	COG1396	sequence-specific DNA binding
IG196_RS23375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IG196_RS23380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG196_RS23385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IG196_RS23390	COG1047	Peptidyl-prolyl cis-trans
IG196_RS23395	COG2003	Belongs to the UPF0758 family
IG196_RS23405	COG0737	Belongs to the 5'-nucleotidase family
IG196_RS23420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IG196_RS23430	COG0765	amino acid transport
IG196_RS23435	COG0765	amino acid transport
IG196_RS23455	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS23465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_RS23470	COG0765	amino acid transport
IG196_RS23475	COG1126	abc transporter atp-binding protein
IG196_RS23480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_RS23485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG196_RS23500	COG0477	Major facilitator Superfamily
IG196_RS23505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IG196_RS23510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IG196_RS23515	COG1845	cytochrome c oxidase, subunit III
IG196_RS23520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IG196_RS23535	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IG196_RS23540	COG1272	protein, Hemolysin III
IG196_RS23545	COG2900	Belongs to the SlyX family
IG196_RS23550	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS23565	COG0583	DNA-binding transcription factor activity
IG196_RS23570	COG0477	Major facilitator Superfamily
IG196_RS23575	COG0583	DNA-binding transcription factor activity
IG196_RS23585	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IG196_RS23590	COG0709	Synthesizes selenophosphate from selenide and ATP
IG196_RS23595	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IG196_RS23600	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IG196_RS23605	COG3639	organic phosphonate transmembrane transporter activity
IG196_RS23610	COG3639	organic phosphonate transmembrane transporter activity
IG196_RS23615	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IG196_RS23620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IG196_RS23630	COG0243	molybdopterin cofactor binding
IG196_RS23650	COG0725	ABC transporter, periplasmic molybdate-binding protein
IG196_RS23655	COG4149	molybdate abc transporter
IG196_RS23665	COG0778	Nitroreductase
IG196_RS23680	COG0583	DNA-binding transcription factor activity
IG196_RS23685	COG0489	protein tyrosine kinase activity
IG196_RS23695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG196_RS23700	COG1473	amidohydrolase
IG196_RS23705	COG1522	sequence-specific DNA binding
IG196_RS23715	COG3132	Protein of unknown function, DUF480
IG196_RS23725	COG0473	3-isopropylmalate dehydrogenase activity
IG196_RS23730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG196_RS23755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS23765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IG196_RS23765	COG1024	Enoyl-CoA hydratase
IG196_RS23770	COG0659	secondary active sulfate transmembrane transporter activity
IG196_RS23790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IG196_RS23795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IG196_RS23800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IG196_RS23805	COG0602	queuosine metabolic process
IG196_RS23810	COG0720	synthase
IG196_RS23815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IG196_RS23825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IG196_RS23830	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IG196_RS23840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IG196_RS23845	COG0588	phosphoglycerate mutase activity
IG196_RS23850	COG0793	Belongs to the peptidase S41A family
IG196_RS23855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IG196_RS23860	COG2982	Protein involved in outer membrane biogenesis
IG196_RS23870	COG2197	response regulator
IG196_RS23875	COG4585	Histidine kinase
IG196_RS23880	COG5487	UPF0391 membrane protein
IG196_RS23900	COG2823	Periplasmic or secreted lipoprotein
IG196_RS23930	COG0494	nUDIX hydrolase
IG196_RS23945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IG196_RS23965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IG196_RS23980	COG2226	methyltransferase
IG196_RS24005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG196_RS24015	COG1175	transmembrane transport
IG196_RS24020	COG0395	ABC-type sugar transport system, permease component
IG196_RS24025	COG3842	ATPase activity
IG196_RS24030	COG0584	glycerophosphoryl diester phosphodiesterase
IG196_RS24035	COG1511	domain protein
IG196_RS24035	COG3264	Mechanosensitive ion channel
IG196_RS24040	COG1522	sequence-specific DNA binding
IG196_RS24050	COG4120	Belongs to the binding-protein-dependent transport system permease family
IG196_RS24055	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IG196_RS24070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IG196_RS24075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IG196_RS24080	COG2890	protein-(glutamine-N5) methyltransferase activity
IG196_RS24085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IG196_RS24090	COG1253	flavin adenine dinucleotide binding
IG196_RS24095	COG0741	lytic transglycosylase activity
IG196_RS24100	COG0442	prolyl-tRNA aminoacylation
IG196_RS24105	COG0494	nUDIX hydrolase
IG196_RS24115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IG196_RS24120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IG196_RS24125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IG196_RS24130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IG196_RS24135	COG0142	geranyltranstransferase activity
IG196_RS24155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IG196_RS24165	COG1696	Membrane protein involved in D-alanine export
IG196_RS24175	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IG196_RS24180	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IG196_RS24185	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IG196_RS24185	COG2755	lipolytic protein G-D-S-L family
IG196_RS24190	COG0494	nUDIX hydrolase
IG196_RS24200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IG196_RS24205	COG0653	protein targeting
IG196_RS24215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IG196_RS24235	COG0831	urea catabolic process
IG196_RS24245	COG0832	Belongs to the urease beta subunit family
IG196_RS24250	COG0804	urea catabolic process
IG196_RS24265	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IG196_RS24270	COG0830	nickel cation binding
IG196_RS24275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IG196_RS24285	COG0583	DNA-binding transcription factor activity
IG196_RS24310	COG0745	RESPONSE REGULATOR receiver
IG196_RS24330	COG2205	protein histidine kinase activity
IG196_RS24335	COG0745	RESPONSE REGULATOR receiver
IG196_RS24340	COG1309	transcriptional regulator
IG196_RS24350	COG0493	'glutamate synthase
IG196_RS24360	COG1953	Uracil, thiamine, allantoin
IG196_RS24385	COG1335	isochorismatase
IG196_RS24390	COG1335	isochorismatase
IG196_RS24400	COG0670	Belongs to the BI1 family
IG196_RS24405	COG1959	2 iron, 2 sulfur cluster binding
IG196_RS24430	COG0589	response to stress
IG196_RS24455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_RS24460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IG196_RS24470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IG196_RS24505	COG3278	Belongs to the heme-copper respiratory oxidase family
IG196_RS24515	COG2217	Heavy metal translocating P-type atpase
IG196_RS24565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG196_RS24570	COG2814	Major facilitator Superfamily
IG196_RS24575	COG4771	TonB-dependent receptor
IG196_RS24600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IG196_RS24605	COG2199	diguanylate cyclase activity
IG196_RS24605	COG3287	FIST C domain
IG196_RS24605	COG2200	EAL domain
IG196_RS24655	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS24660	COG1703	isobutyryl-CoA mutase activity
IG196_RS24665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS24670	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_RS24670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_RS24675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_RS24675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG196_RS24680	COG1024	Enoyl-CoA hydratase
IG196_RS24705	COG3246	L-lysine catabolic process to acetate
IG196_RS24710	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS24720	COG3246	L-lysine catabolic process to acetate
IG196_RS24725	COG2175	clavaminate synthase activity
IG196_RS24750	COG2207	Transcriptional regulator
IG196_RS24760	COG2175	clavaminate synthase activity
IG196_RS24765	COG3246	L-lysine catabolic process to acetate
IG196_RS24795	COG1388	LysM domain
IG196_RS24795	COG4942	peptidase
IG196_RS24805	COG5002	protein histidine kinase activity
IG196_RS24805	COG2205	protein histidine kinase activity
IG196_RS24805	COG0784	Response regulator, receiver
IG196_RS24810	COG2197	response regulator
IG196_RS24825	COG0582	viral genome integration into host DNA
IG196_RS24835	COG1304	FMN binding
IG196_RS24840	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS24855	COG0776	regulation of translation
IG196_RS24920	COG3468	outer membrane autotransporter barrel domain protein
IG196_RS25005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG196_RS25025	COG1473	amidohydrolase
IG196_RS25045	COG0625	glutathione transferase activity
IG196_RS25050	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG196_RS25090	COG2175	clavaminate synthase activity
IG196_RS25185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IG196_RS25190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IG196_RS25195	COG0277	FAD linked oxidase domain protein
IG196_RS25295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IG196_RS25300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IG196_RS25320	COG1561	YicC-like family, N-terminal region
IG196_RS25325	COG0194	GDP metabolic process
IG196_RS25330	COG1758	RNA polymerase activity
IG196_RS25335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IG196_RS25365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG196_RS25380	COG1420	regulation of RNA biosynthetic process
IG196_RS25385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IG196_RS25390	COG0497	DNA recombination
IG196_RS25395	COG1660	Displays ATPase and GTPase activities
IG196_RS25405	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IG196_RS25410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IG196_RS25425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IG196_RS25435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IG196_RS25440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IG196_RS25445	COG0193	aminoacyl-tRNA hydrolase activity
IG196_RS25455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IG196_RS25465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG196_RS25475	COG4608	Belongs to the ABC transporter superfamily
IG196_RS25485	COG0747	negative chemotaxis
IG196_RS25490	COG0154	amidase activity
IG196_RS25510	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IG196_RS25515	COG0588	phosphoglycerate mutase activity
IG196_RS25520	COG2267	carboxylic ester hydrolase activity
IG196_RS25525	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IG196_RS25530	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IG196_RS25535	COG1984	allophanate hydrolase subunit 2
IG196_RS25540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IG196_RS25545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IG196_RS25550	COG0742	ribosomal rna small subunit methyltransferase
IG196_RS25565	COG0612	Peptidase, M16
IG196_RS25570	COG0612	Peptidase, M16
IG196_RS25580	COG2205	protein histidine kinase activity
IG196_RS25585	COG2197	response regulator
IG196_RS25600	COG0583	DNA-binding transcription factor activity
IG196_RS25610	COG4335	DNA alkylation repair
IG196_RS25615	COG1999	signal sequence binding
IG196_RS25620	COG0109	protoheme IX farnesyltransferase activity
IG196_RS25655	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IG196_RS25660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IG196_RS25675	COG2226	methyltransferase
IG196_RS25680	COG1040	competence protein
IG196_RS25685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IG196_RS25700	COG0489	protein tyrosine kinase activity
IG196_RS25720	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS25735	COG1024	Enoyl-CoA hydratase
IG196_RS25755	COG1960	acyl-CoA dehydrogenase activity
IG196_RS25770	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IG196_RS25785	COG5507	3-demethylubiquinone-9 3-methyltransferase
IG196_RS25795	COG2186	Transcriptional regulator
IG196_RS25800	COG0154	amidase activity
IG196_RS25820	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IG196_RS25830	COG0430	RNA-3'-phosphate cyclase activity
IG196_RS25845	COG1690	Belongs to the RtcB family
IG196_RS25855	COG4650	regulator
IG196_RS25870	COG1073	alpha beta
IG196_RS25880	COG4771	TonB-dependent receptor
IG196_RS25895	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG196_RS25900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG196_RS25920	COG0601	transmembrane transport
IG196_RS25945	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IG196_RS25950	COG0583	DNA-binding transcription factor activity
IG196_RS25955	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS25965	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS25980	COG0395	ABC-type sugar transport system, permease component
IG196_RS25985	COG0693	protein deglycase activity
IG196_RS26010	COG0183	Belongs to the thiolase family
IG196_RS26015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IG196_RS26025	COG1414	Transcriptional regulator
IG196_RS26035	COG3063	Type IV pilus biogenesis stability protein PilW
IG196_RS26060	COG4964	Belongs to the GSP D family
IG196_RS26120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_RS26125	COG2274	protein secretion by the type I secretion system
IG196_RS26135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IG196_RS26155	COG0583	DNA-binding transcription factor activity
IG196_RS26160	COG3485	protocatechuate 3,4-dioxygenase
IG196_RS26165	COG3485	protocatechuate 3,4-dioxygenase
IG196_RS26175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG196_RS26245	COG1902	pentaerythritol trinitrate reductase activity
IG196_RS26250	COG0697	spore germination
IG196_RS26280	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS26285	COG1053	succinate dehydrogenase
IG196_RS26300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IG196_RS26305	COG0540	Belongs to the ATCase OTCase family
IG196_RS26310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IG196_RS26315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IG196_RS26320	COG1678	Uncharacterized ACR, COG1678
IG196_RS26325	COG0415	Belongs to the DNA photolyase family
IG196_RS26330	COG2198	Histidine kinase
IG196_RS26330	COG0784	Response regulator, receiver
IG196_RS26330	COG0643	Histidine kinase
IG196_RS26355	COG1773	rubredoxin
IG196_RS26365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IG196_RS26370	COG0154	amidase activity
IG196_RS26375	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS26390	COG0138	bifunctional purine biosynthesis protein purh
IG196_RS26395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IG196_RS26405	COG1238	metal cluster binding
IG196_RS26415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG196_RS26425	COG0012	GTP binding
IG196_RS26430	COG1879	ABC-type sugar transport system periplasmic component
IG196_RS26435	COG1129	ABC transporter
IG196_RS26440	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_RS26445	COG1609	Transcriptional regulator
IG196_RS26450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG196_RS26455	COG1869	D-ribose catabolic process
IG196_RS26465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_RS26485	COG1024	Enoyl-CoA hydratase
IG196_RS26550	COG1960	acyl-CoA dehydrogenase activity
IG196_RS26555	COG1960	acyl-CoA dehydrogenase activity
IG196_RS26565	COG0778	Nitroreductase
IG196_RS26585	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS26590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS26610	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS26660	COG1024	Enoyl-CoA hydratase
IG196_RS26705	COG0183	Belongs to the thiolase family
IG196_RS26715	COG1024	Enoyl-CoA hydratase
IG196_RS26725	COG1024	Enoyl-CoA hydratase
IG196_RS26725	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_RS26735	COG1946	Acyl-CoA thioesterase
IG196_RS26740	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_RS26740	COG1024	Enoyl-CoA hydratase
IG196_RS26745	COG0183	Belongs to the thiolase family
IG196_RS26750	COG2909	trisaccharide binding
IG196_RS26755	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS26770	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS26775	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS26780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS26795	COG1024	Enoyl-CoA hydratase
IG196_RS26805	COG1960	acyl-CoA dehydrogenase activity
IG196_RS26810	COG1960	acyl-CoA dehydrogenase activity
IG196_RS26830	COG2255	four-way junction helicase activity
IG196_RS26835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IG196_RS26840	COG2267	carboxylic ester hydrolase activity
IG196_RS26845	COG2453	phosphatase
IG196_RS26845	COG0671	phosphoesterase, PA-phosphatase related
IG196_RS26860	COG4589	Belongs to the CDS family
IG196_RS26925	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS26940	COG0632	four-way junction helicase activity
IG196_RS26945	COG1702	phosphate starvation-inducible protein PhoH
IG196_RS26950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IG196_RS26955	COG4106	trans-aconitate 2-methyltransferase activity
IG196_RS26960	COG1490	D-aminoacyl-tRNA deacylase activity
IG196_RS26965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IG196_RS26980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IG196_RS26990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IG196_RS26995	COG2814	Major facilitator Superfamily
IG196_RS27000	COG0316	Belongs to the HesB IscA family
IG196_RS27005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IG196_RS27010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IG196_RS27025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IG196_RS27030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IG196_RS27045	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IG196_RS27065	COG3243	poly(R)-hydroxyalkanoic acid synthase
IG196_RS27075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IG196_RS27100	COG4555	ABC transporter
IG196_RS27125	COG2423	ornithine cyclodeaminase activity
IG196_RS27130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IG196_RS27135	COG0683	leucine binding
IG196_RS27145	COG0477	Major facilitator Superfamily
IG196_RS27165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG196_RS27170	COG2146	nitrite reductase [NAD(P)H] activity
IG196_RS27175	COG2116	formate transmembrane transporter activity
IG196_RS27180	COG0515	serine threonine protein kinase
IG196_RS27180	COG2815	serine threonine protein kinase
IG196_RS27190	COG1254	Belongs to the acylphosphatase family
IG196_RS27200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS27215	COG1414	Transcriptional regulator
IG196_RS27220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG196_RS27245	COG1024	Enoyl-CoA hydratase
IG196_RS27250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG196_RS27255	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS27260	COG1960	acyl-CoA dehydrogenase activity
IG196_RS27275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG196_RS27280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IG196_RS27285	COG3012	SEC-C Motif Domain Protein
IG196_RS27320	COG1408	metallophosphoesterase
IG196_RS27325	COG1960	acyl-CoA dehydrogenase activity
IG196_RS27335	COG0183	Belongs to the thiolase family
IG196_RS27340	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IG196_RS27345	COG0288	reversible hydration of carbon dioxide
IG196_RS27350	COG0789	Transcriptional regulator
IG196_RS27365	COG0564	pseudouridine synthase activity
IG196_RS27385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IG196_RS27400	COG0751	glycine-tRNA ligase activity
IG196_RS27405	COG0752	glycyl-tRNA synthetase alpha subunit
IG196_RS27410	COG1597	lipid kinase activity
IG196_RS27420	COG0671	phosphoesterase, PA-phosphatase related
IG196_RS27435	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IG196_RS27450	COG1522	sequence-specific DNA binding
IG196_RS27465	COG3186	Phenylalanine-4-hydroxylase
IG196_RS27470	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS27510	COG0488	(ABC) transporter
IG196_RS27515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_RS27560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_RS27570	COG3550	peptidyl-serine autophosphorylation
IG196_RS27610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG196_RS27635	COG0439	Biotin carboxylase
IG196_RS27640	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS27655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IG196_RS27655	COG2124	cytochrome p450
IG196_RS27685	COG1505	serine-type exopeptidase activity
IG196_RS27700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IG196_RS27730	COG2084	Dehydrogenase
IG196_RS27740	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IG196_RS27745	COG0792	nuclease activity
IG196_RS27750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IG196_RS27770	COG1309	transcriptional regulator
IG196_RS27775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_RS27780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG196_RS27830	COG3118	belongs to the thioredoxin family
IG196_RS27850	COG1879	ABC-type sugar transport system periplasmic component
IG196_RS27855	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG196_RS27870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IG196_RS27875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IG196_RS27880	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IG196_RS27885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IG196_RS27890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IG196_RS27895	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IG196_RS27905	COG0356	it plays a direct role in the translocation of protons across the membrane
IG196_RS27920	COG2921	Belongs to the UPF0250 family
IG196_RS27925	COG0321	lipoyl(octanoyl) transferase activity
IG196_RS27930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IG196_RS27940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IG196_RS27945	COG1012	belongs to the aldehyde dehydrogenase family
IG196_RS27955	COG2271	Major facilitator Superfamily
IG196_RS27970	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS27975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IG196_RS27995	COG2130	NADP-dependent
IG196_RS28030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG196_RS28035	COG1136	(ABC) transporter
IG196_RS28035	COG0577	efflux transmembrane transporter activity
IG196_RS28040	COG1538	Outer membrane efflux protein
IG196_RS28045	COG2205	protein histidine kinase activity
IG196_RS28070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IG196_RS28075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG196_RS28090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG196_RS28095	COG3909	cytochrome
IG196_RS28110	COG0678	peroxiredoxin activity
IG196_RS28115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IG196_RS28120	COG0255	Belongs to the universal ribosomal protein uL29 family
IG196_RS28125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IG196_RS28130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IG196_RS28135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IG196_RS28140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IG196_RS28145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IG196_RS28150	COG0089	rRNA binding
IG196_RS28155	COG0088	Forms part of the polypeptide exit tunnel
IG196_RS28160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IG196_RS28175	COG0051	transcription antitermination factor activity, RNA binding
IG196_RS28180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IG196_RS28185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IG196_RS28190	COG0049	tRNA binding
IG196_RS28195	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IG196_RS28200	COG1686	Belongs to the peptidase S11 family
IG196_RS28205	COG2945	thiolester hydrolase activity
IG196_RS28220	COG1981	membrane
IG196_RS28230	COG0598	Magnesium transport protein CorA
IG196_RS28240	COG0583	DNA-binding transcription factor activity
IG196_RS28250	COG0412	Dienelactone hydrolase
IG196_RS28260	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS28265	COG2095	MarC family integral membrane protein
IG196_RS28280	COG1022	Amp-dependent synthetase and ligase
IG196_RS28300	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_RS28315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IG196_RS28320	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_RS28335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IG196_RS28340	COG1652	LysM domain
IG196_RS28345	COG2207	Transcriptional regulator
IG196_RS28360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IG196_RS28385	COG0640	Transcriptional regulator
IG196_RS28395	COG0574	Belongs to the PEP-utilizing enzyme family
IG196_RS28395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IG196_RS28405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IG196_RS28410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IG196_RS28420	COG0640	Transcriptional regulator
IG196_RS28435	COG0625	glutathione transferase activity
IG196_RS28445	COG1131	(ABC) transporter
IG196_RS28450	COG0842	Transport permease protein
IG196_RS28460	COG1846	Transcriptional regulator
IG196_RS28465	COG1764	response to oxidative stress
IG196_RS28475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IG196_RS28480	COG0583	DNA-binding transcription factor activity
IG196_RS28485	COG1960	acyl-CoA dehydrogenase activity
IG196_RS28505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS28540	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IG196_RS28550	COG0714	Associated with various cellular activities
IG196_RS28570	COG0326	Molecular chaperone. Has ATPase activity
IG196_RS28575	COG1840	ABC-type Fe3 transport system, periplasmic component
IG196_RS28580	COG0583	DNA-binding transcription factor activity
IG196_RS28590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IG196_RS28600	COG0642	Histidine kinase
IG196_RS28615	COG1187	pseudouridine synthase activity
IG196_RS28620	COG1051	belongs to the nudix hydrolase family
IG196_RS28620	COG1056	cytidyltransferase-related domain
IG196_RS28630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IG196_RS28650	COG0745	RESPONSE REGULATOR receiver
IG196_RS28655	COG2205	protein histidine kinase activity
IG196_RS28665	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IG196_RS28670	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IG196_RS28675	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IG196_RS28700	COG2391	methyltransferase activity
IG196_RS28735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IG196_RS28740	COG4654	Cytochrome c, class I
IG196_RS28770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG196_RS28785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IG196_RS28825	COG1022	Amp-dependent synthetase and ligase
IG196_RS28830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_RS28840	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS28880	COG2252	PERMEase
IG196_RS28950	COG0318	PFAM AMP-dependent synthetase and ligase
IG196_RS28990	COG1940	carbohydrate kinase activity
IG196_RS28995	COG1129	ABC transporter
IG196_RS29000	COG4214	carbohydrate transport
IG196_RS29005	COG4213	ABC transporter substrate-binding protein
IG196_RS29015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_RS29025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IG196_RS29030	COG0022	dehydrogenase e1 component
IG196_RS29040	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS29045	COG0583	DNA-binding transcription factor activity
IG196_RS29060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG196_RS29075	COG1024	Enoyl-CoA hydratase
IG196_RS29080	COG1960	acyl-CoA dehydrogenase activity
IG196_RS29100	COG0203	ribosomal protein L17
IG196_RS29105	COG0202	RNA polymerase activity
IG196_RS29110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IG196_RS29115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IG196_RS29120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IG196_RS29125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IG196_RS29130	COG0201	protein transport
IG196_RS29135	COG0200	Binds to the 23S rRNA
IG196_RS29140	COG1841	ribosomal large subunit assembly
IG196_RS29145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IG196_RS29150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IG196_RS29155	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IG196_RS29160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IG196_RS29165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IG196_RS29170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IG196_RS29175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IG196_RS29180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IG196_RS29200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IG196_RS29205	COG0783	Belongs to the Dps family
IG196_RS29400	COG4770	biotin carboxylase activity
IG196_RS29405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IG196_RS29410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IG196_RS29415	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IG196_RS29465	COG1280	lysine exporter protein (LysE YggA)
IG196_RS29470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IG196_RS29475	COG1090	epimerase
IG196_RS29485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IG196_RS29490	COG0343	queuine tRNA-ribosyltransferase activity
IG196_RS29550	COG0284	orotidine-5'-phosphate decarboxylase activity
IG196_RS29565	COG1214	PFAM Peptidase M22, glycoprotease
IG196_RS29575	COG1349	DNA-binding transcription factor activity
IG196_RS29580	COG0494	nUDIX hydrolase
IG196_RS29585	COG2027	D-alanyl-D-alanine carboxypeptidase
IG196_RS29595	COG0009	L-threonylcarbamoyladenylate synthase
IG196_RS29600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IG196_RS29605	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IG196_RS29615	COG3620	sequence-specific DNA binding
IG196_RS29620	COG3550	peptidyl-serine autophosphorylation
IG196_RS29630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IG196_RS29640	COG1522	sequence-specific DNA binding
IG196_RS29645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IG196_RS29655	COG0469	pyruvate kinase activity
IG196_RS29660	COG0126	phosphoglycerate kinase activity
IG196_RS29680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG196_RS29710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IG196_RS29720	COG0242	peptide deformylase activity
IG196_RS29730	COG0758	DNA mediated transformation
IG196_RS29735	COG2922	Belongs to the Smg family
IG196_RS29745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IG196_RS29750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IG196_RS29755	COG1862	Preprotein translocase
IG196_RS29765	COG1522	sequence-specific DNA binding
IG196_RS29800	COG0765	amino acid transport
IG196_RS29805	COG2814	Major facilitator Superfamily
IG196_RS29815	COG1845	cytochrome c oxidase, subunit III
IG196_RS29825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IG196_RS29830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IG196_RS29855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS29885	COG0251	oxidation-reduction process
IG196_RS29895	COG3622	Belongs to the hyi family
IG196_RS29900	COG0235	Class ii aldolase
IG196_RS29905	COG3395	kinase activity
IG196_RS29910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG196_RS29915	COG2084	Dehydrogenase
IG196_RS29920	COG2271	Major facilitator Superfamily
IG196_RS29925	COG2186	Transcriptional regulator
IG196_RS29935	COG1522	sequence-specific DNA binding
IG196_RS29965	COG4566	intracellular signal transduction
IG196_RS29985	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IG196_RS29995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG196_RS30000	COG1595	DNA-templated transcription, initiation
IG196_RS30020	COG0625	glutathione transferase activity
IG196_RS30030	COG4772	TonB-dependent receptor
IG196_RS30050	COG0861	Integral membrane protein TerC family
IG196_RS30060	COG1950	PFAM Membrane protein of
IG196_RS30065	COG4783	chaperone-mediated protein folding
IG196_RS30070	COG0315	cyclic pyranopterin monophosphate synthase activity
IG196_RS30125	COG1716	ATPase activity
IG196_RS30130	COG0631	protein serine/threonine phosphatase activity
IG196_RS30135	COG0861	Integral membrane protein TerC family
IG196_RS30140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IG196_RS30145	COG0045	succinate-CoA ligase (ADP-forming) activity
IG196_RS30150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IG196_RS30155	COG0427	acetyl-CoA hydrolase
IG196_RS30160	COG3781	membrane
IG196_RS30170	COG4682	membrane
IG196_RS30180	COG2137	regulation of response to DNA damage stimulus
IG196_RS30185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IG196_RS30200	COG0642	Histidine kinase
IG196_RS30215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IG196_RS30215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IG196_RS30235	COG0583	DNA-binding transcription factor activity
IG196_RS30240	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS30265	COG1960	acyl-CoA dehydrogenase activity
IG196_RS30275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IG196_RS30285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IG196_RS30290	COG1522	sequence-specific DNA binding
IG196_RS30300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IG196_RS30305	COG0513	Belongs to the DEAD box helicase family
IG196_RS30335	COG0697	spore germination
IG196_RS30345	COG1802	Transcriptional regulator
IG196_RS30360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG196_RS30385	COG1473	amidohydrolase
IG196_RS30390	COG1741	Belongs to the pirin family
IG196_RS30400	COG0583	DNA-binding transcription factor activity
IG196_RS30405	COG1047	Peptidyl-prolyl cis-trans
IG196_RS30410	COG3025	triphosphatase activity
IG196_RS30455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IG196_RS30460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IG196_RS30465	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IG196_RS30480	COG0006	proline dipeptidase activity
IG196_RS30505	COG4953	penicillin-binding protein 1C
IG196_RS30510	COG2373	Large extracellular alpha-helical protein
IG196_RS30535	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IG196_RS30555	COG0280	phosphate acetyltransferase
IG196_RS30555	COG0281	malic enzyme
IG196_RS30575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IG196_RS30580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IG196_RS30585	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IG196_RS30595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IG196_RS30610	COG2814	Major facilitator Superfamily
IG196_RS30615	COG2267	carboxylic ester hydrolase activity
IG196_RS30635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG196_RS30640	COG1739	Uncharacterized protein family UPF0029
IG196_RS30645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG196_RS30645	COG2813	Specifically methylates the guanine in position
IG196_RS30650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG196_RS30655	COG2119	membrane
IG196_RS30660	COG0724	RNA recognition motif
IG196_RS30665	COG0300	oxidoreductase activity
IG196_RS30675	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IG196_RS30700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IG196_RS30705	COG0706	membrane insertase activity
IG196_RS30710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IG196_RS30715	COG0594	ribonuclease P activity
IG196_RS30720	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IG196_RS30725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IG196_RS30730	COG0592	DNA-directed DNA polymerase activity
IG196_RS30765	COG1408	metallophosphoesterase
IG196_RS30775	COG0392	lysyltransferase activity
IG196_RS30780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_RS30785	COG3568	Endonuclease Exonuclease Phosphatase
IG196_RS30810	COG0456	acetyltransferase
IG196_RS30810	COG0454	-acetyltransferase
IG196_RS30815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IG196_RS30840	COG1472	Belongs to the glycosyl hydrolase 3 family
IG196_RS30855	COG2205	protein histidine kinase activity
IG196_RS30860	COG0745	RESPONSE REGULATOR receiver
IG196_RS30875	COG2608	mercury ion transmembrane transporter activity
IG196_RS30880	COG2217	Heavy metal translocating P-type atpase
IG196_RS30905	COG0745	RESPONSE REGULATOR receiver
IG196_RS30910	COG0642	Histidine kinase
IG196_RS30915	COG0456	acetyltransferase
IG196_RS30925	COG1902	pentaerythritol trinitrate reductase activity
IG196_RS30935	COG3181	Tripartite tricarboxylate transporter family receptor
IG196_RS30945	COG1024	Enoyl-CoA hydratase
IG196_RS30950	COG1024	Enoyl-CoA hydratase
IG196_RS30955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS30975	COG0445	tRNA wobble uridine modification
IG196_RS30980	COG0357	Ribosomal RNA small subunit methyltransferase G
IG196_RS30990	COG1192	Involved in chromosome partitioning
IG196_RS31010	COG0277	FAD linked oxidase domain protein
IG196_RS31020	COG2096	Adenosyltransferase
IG196_RS31110	COG0583	DNA-binding transcription factor activity
IG196_RS31130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IG196_RS31135	COG2894	cell division
IG196_RS31140	COG0850	regulation of cytokinetic process
IG196_RS31145	COG2233	PERMEase
IG196_RS31150	COG2050	protein possibly involved in aromatic compounds catabolism
IG196_RS31180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG196_RS31195	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG196_RS31205	COG3246	L-lysine catabolic process to acetate
IG196_RS31230	COG1309	transcriptional regulator
IG196_RS31235	COG1819	glycosyl
IG196_RS31240	COG3284	Transcriptional regulator
IG196_RS31245	COG1942	4-Oxalocrotonate Tautomerase
IG196_RS31250	COG1028	Short-chain dehydrogenase reductase Sdr
IG196_RS31305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IG196_RS31335	COG1959	2 iron, 2 sulfur cluster binding
IG196_RS31355	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IG196_RS31360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS31365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS31370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG196_RS31370	COG1116	anion transmembrane transporter activity
IG196_RS31385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG196_RS31395	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IG196_RS31420	COG0583	DNA-binding transcription factor activity
IG196_RS31425	COG1960	acyl-CoA dehydrogenase activity
IG196_RS31430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG196_RS31445	COG0583	DNA-binding transcription factor activity
IG196_RS31455	COG1473	amidohydrolase
IG196_RS31460	COG1760	l-serine dehydratase
IG196_RS31475	COG1573	uracil-dna glycosylase
IG196_RS31490	COG0583	DNA-binding transcription factor activity
IG196_RS31515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG196_RS31525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG196_RS31535	COG1129	ABC transporter
IG196_RS31540	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG196_RS31550	COG0683	leucine binding
IG196_RS31570	COG2066	Belongs to the glutaminase family
IG196_RS31585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG196_RS31595	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IG196_RS31605	COG0700	Nucleoside recognition
IG196_RS31610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG196_RS31625	COG0410	ABC transporter
IG196_RS31645	COG0683	leucine binding
IG196_RS31650	COG0633	Ferredoxin
IG196_RS31720	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IG196_RS31730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG196_RS31735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG196_RS31750	COG1070	Carbohydrate kinase
IG196_RS31780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG196_RS31785	COG1116	anion transmembrane transporter activity
IG196_RS31795	COG2986	histidine ammonia-lyase
IG196_RS31800	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IG196_RS31815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG196_RS31820	COG0765	amino acid transport
IG196_RS31830	COG1228	amidohydrolase
IG196_RS31865	COG5380	lipid catabolic process
IG196_RS31870	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IG196_RS31875	COG1410	methionine synthase
IG196_RS31875	COG0646	methionine synthase
IG196_RS31900	COG1309	transcriptional regulator
IG196_RS31930	COG0683	leucine binding
IG196_RS31950	COG1335	isochorismatase