locus-tag class description G3W89_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G3W89_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G3W89_RS00015 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W89_RS00030 ENOG4107RN3 metallophosphoesterase G3W89_RS00040 ENOG41061N2 exported protein G3W89_RS00055 ENOG4107UXM Membrane G3W89_RS00060 ENOG4105DZQ phospholipase D Transphosphatidylase G3W89_RS00065 ENOG4105X23 Endonuclease Exonuclease phosphatase G3W89_RS00085 ENOG4105EUB pirin domain protein G3W89_RS00090 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase G3W89_RS00110 ENOG4108JQC penicillin-binding protein 1A G3W89_RS00130 ENOG4105EB3 Histidine kinase G3W89_RS00135 ENOG4105E3W Two component transcriptional regulator (Winged helix family G3W89_RS00145 ENOG410681U heavy metal transport detoxification protein G3W89_RS00155 ENOG4105ECM Sensor protein basS pmrB G3W89_RS00160 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3W89_RS00165 ENOG4105CBP Major Facilitator G3W89_RS00170 ENOG4108K3A Glutathione S-transferase G3W89_RS00185 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G3W89_RS00190 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G3W89_RS00200 ENOG4107QJE Chromosome Partitioning Protein G3W89_RS00210 ENOG4105FA0 parb-like partition protein G3W89_RS00220 ENOG4105CQB FAD linked oxidase domain protein G3W89_RS00225 ENOG4108WBT adenosyltransferase G3W89_RS00260 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) G3W89_RS00265 ENOG4107QMS site-determining protein G3W89_RS00270 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) G3W89_RS00280 ENOG4105C2W permease G3W89_RS00285 ENOG4105KA0 thioesterase Superfamily protein G3W89_RS00300 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G3W89_RS00305 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS00335 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) G3W89_RS00340 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme G3W89_RS00365 ENOG4105F8J Adenylate Guanylate cyclase G3W89_RS00380 ENOG4108Z9W Outer membrane porin G3W89_RS00385 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3W89_RS00400 ENOG4105E2B Taurine dioxygenase G3W89_RS00420 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G3W89_RS00450 ENOG4107QMH DNA methylase G3W89_RS00460 ENOG4108IV0 ABC, transporter G3W89_RS00465 ENOG4105C0Z ABC transporter G3W89_RS00475 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS00485 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G3W89_RS00505 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G3W89_RS00530 ENOG41068W2 Cytochrome p-450 G3W89_RS00535 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G3W89_RS00540 ENOG4108X7A Terpene synthase metal-binding domain-containing protein G3W89_RS00560 ENOG4105BZU Histidine kinase G3W89_RS00565 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G3W89_RS00575 ENOG4105DTD Dehydrogenase G3W89_RS00605 ENOG41082JN Transcriptional regulator G3W89_RS00640 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G3W89_RS00660 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G3W89_RS00705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3W89_RS00710 ENOG4105F38 ABC transporter, permease G3W89_RS00715 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component G3W89_RS00730 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) G3W89_RS00745 ENOG4107S9D Alpha beta hydrolase G3W89_RS00770 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS00780 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G3W89_RS00805 ENOG4105K4H Nlp p60 protein G3W89_RS00815 ENOG4107R6F Alpha Beta Hydrolase Fold protein G3W89_RS00820 ENOG4105BZU Histidine kinase G3W89_RS00825 ENOG4108KSA LysR family transcriptional regulator G3W89_RS00830 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G3W89_RS00840 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS00850 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W89_RS00870 ENOG4105DQE DNA ligase G3W89_RS00880 ENOG4105FDF Could be involved in DNA repair (By similarity) G3W89_RS00885 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G3W89_RS00890 ENOG4107JEE Short-chain dehydrogenase reductase Sdr G3W89_RS00895 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G3W89_RS00905 ENOG4105VYA Uncharacterized conserved protein (DUF2132) G3W89_RS00915 ENOG4108SKZ Patatin-like phospholipase G3W89_RS00940 ENOG4105KWG Pfam:DUF1696 G3W89_RS00955 ENOG4108V1U phospholipid-binding protein G3W89_RS01000 ENOG4107RSM transcriptional regulator G3W89_RS01005 ENOG4108Z4U Ferredoxin G3W89_RS01025 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W89_RS01045 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G3W89_RS01060 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3W89_RS01065 ENOG4105F27 Major Facilitator G3W89_RS01070 ENOG41086DT Membrane protein of unknown function G3W89_RS01090 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G3W89_RS01095 ENOG4105D3R alkyl hydroperoxide reductase G3W89_RS01100 ENOG4105ETT transcriptional Regulator, LysR family G3W89_RS01105 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS01110 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS01130 ENOG4105EMU Dehydrogenase G3W89_RS01170 ENOG4105ETE Transcriptional regulator (LacI family G3W89_RS01180 ENOG4106PBJ Serine threonine-protein kinase Pkn6 G3W89_RS01195 ENOG4105CSV Glutaminase G3W89_RS01210 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3W89_RS01240 ENOG4105DGI Alkaline phosphatase G3W89_RS01260 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) G3W89_RS01265 ENOG4105C7B Threonine dehydratase G3W89_RS01270 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W89_RS01285 ENOG4105C9U ATP-dependent DNA helicase RecQ G3W89_RS01310 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3W89_RS01320 ENOG4105CZE histidine utilization repressor G3W89_RS01325 ENOG4105C84 Histidine ammonia-lyase G3W89_RS01330 ENOG4105CGP Urocanate hydratase G3W89_RS01355 ENOG4105CI2 imidazolone-5-propionate hydrolase G3W89_RS01390 ENOG4105C3R Methionine synthase G3W89_RS01400 ENOG4105F52 Transcriptional regulator G3W89_RS01410 ENOG4105C3R Methionine synthase G3W89_RS01415 ENOG41063ZV G3W89_RS01420 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 G3W89_RS01440 ENOG4108W9H Tetr family transcriptional regulator G3W89_RS01445 ENOG4105DP0 ferredoxin-NADP reductase G3W89_RS01480 ENOG4105C0Z ABC transporter G3W89_RS01485 ENOG4108IV0 ABC, transporter G3W89_RS01490 ENOG4108RWI nicotinamidase G3W89_RS01495 ENOG4108XHQ (2Fe-2S)-binding domain protein G3W89_RS01500 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G3W89_RS01510 ENOG4105CP9 extracellular ligand-binding receptor G3W89_RS01515 ENOG4105C0P Mg chelatase subunit ChlI G3W89_RS01560 ENOG4108YZA Nitrogen regulatory protein pii G3W89_RS01565 ENOG4105BZU Histidine kinase G3W89_RS01575 ENOG4105EU8 FAD linked oxidase domain protein G3W89_RS01580 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G3W89_RS01595 ENOG4108V06 Glutathione peroxidase G3W89_RS01605 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) G3W89_RS01610 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G3W89_RS01620 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G3W89_RS01625 ENOG4105MP9 class II Aldolase G3W89_RS01635 ENOG4105C01 Dihydroxy-acid dehydratase G3W89_RS01655 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase G3W89_RS01660 ENOG4105C26 Dehydrogenase G3W89_RS01680 ENOG4108V8F Transcriptional regulator, MarR family G3W89_RS01685 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G3W89_RS01705 ENOG4105DH7 May be involved in recombination (By similarity) G3W89_RS01710 ENOG4105CM2 brancheD-chain amino acid aminotransferase G3W89_RS01725 ENOG4105E0F Histidine kinase G3W89_RS01730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W89_RS01770 ENOG4105EMU Dehydrogenase G3W89_RS01780 ENOG41061H0 Monooxygenase G3W89_RS01785 ENOG4105F04 LysR family Transcriptional regulator G3W89_RS01790 ENOG4105CGK Exodeoxyribonuclease III G3W89_RS01795 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G3W89_RS01805 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G3W89_RS01810 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W89_RS01815 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G3W89_RS01835 ENOG4105CJN penicillin-binding protein G3W89_RS01850 ENOG4105DHJ ABC, transporter G3W89_RS01870 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein G3W89_RS01875 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G3W89_RS01895 ENOG4105D52 delta-aminolevulinic acid dehydratase G3W89_RS01900 ENOG4108YXA Membrane G3W89_RS01910 ENOG4105NZG Ferredoxin G3W89_RS01915 ENOG4105DHZ alpha beta G3W89_RS01920 ENOG4105DZ1 carboxypeptidase G3W89_RS01925 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G3W89_RS01930 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G3W89_RS01935 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G3W89_RS01940 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G3W89_RS01945 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) G3W89_RS01960 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G3W89_RS01965 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G3W89_RS01970 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G3W89_RS01975 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G3W89_RS01980 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G3W89_RS01985 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) G3W89_RS01990 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) G3W89_RS01995 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) G3W89_RS02000 ENOG41084PQ 50s ribosomal protein l29 G3W89_RS02005 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G3W89_RS02025 ENOG4105T86 cytochrome C G3W89_RS02030 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G3W89_RS02045 ENOG41080Z8 PHOSPHOCARRIER protein G3W89_RS02050 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G3W89_RS02065 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W89_RS02070 ENOG4105E0F Histidine kinase G3W89_RS02075 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G3W89_RS02085 ENOG4105F4P )-transporter G3W89_RS02090 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS02095 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G3W89_RS02100 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G3W89_RS02105 ENOG4108Z43 UPF0250 protein G3W89_RS02110 ENOG4105F0I Aminotransferase G3W89_RS02120 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) G3W89_RS02125 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G3W89_RS02130 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G3W89_RS02135 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G3W89_RS02140 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G3W89_RS02145 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G3W89_RS02150 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G3W89_RS02155 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) G3W89_RS02165 ENOG4105C2J ABC transporter G3W89_RS02170 ENOG4105CNN ABC, transporter G3W89_RS02175 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G3W89_RS02180 ENOG4105CIB oxidoreductase Domain protein G3W89_RS02215 ENOG4108DWA Nad synthetase G3W89_RS02230 ENOG4107T0X DNA ligase G3W89_RS02235 ENOG4107T0X DNA ligase G3W89_RS02240 ENOG4107QRT dEAD DEAH box helicase G3W89_RS02295 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3W89_RS02300 ENOG4105BZS acriflavin resistance protein G3W89_RS02305 ENOG4105C1P efflux transporter, rnd family, mfp subunit G3W89_RS02310 ENOG4108IG5 Transcriptional regulator G3W89_RS02320 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3W89_RS02325 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W89_RS02335 ENOG4108TGY Glutathione S-transferase G3W89_RS02345 ENOG4105DTQ mandelate racemase muconate lactonizing G3W89_RS02360 ENOG4108W5M transcriptional regulator G3W89_RS02365 ENOG4105CQB FAD linked oxidase domain protein G3W89_RS02370 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W89_RS02375 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W89_RS02380 ENOG4105GVF (ABC) transporter G3W89_RS02395 ENOG4105CI2 imidazolone-5-propionate hydrolase G3W89_RS02400 ENOG4105CKI cobalamin synthesis protein G3W89_RS02405 ENOG4105DND Transcriptional regulator G3W89_RS02415 ENOG4105DTQ mandelate racemase muconate lactonizing G3W89_RS02435 ENOG4105CKI cobalamin synthesis protein G3W89_RS02445 ENOG4108WYP Transcriptional regulator G3W89_RS02455 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W89_RS02485 ENOG41069HH 4-oxalocrotonate tautomerase G3W89_RS02490 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G3W89_RS02495 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G3W89_RS02505 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G3W89_RS02510 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W89_RS02520 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G3W89_RS02540 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein G3W89_RS02555 ENOG4105C26 Dehydrogenase G3W89_RS02560 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator G3W89_RS02565 ENOG4105DFW ABC transporter G3W89_RS02575 ENOG4108HWW ABC transporter G3W89_RS02580 ENOG4105C2J ABC transporter G3W89_RS02585 ENOG4107R9N ABC transporter G3W89_RS02590 ENOG41062B0 ABC transporter, permease G3W89_RS02625 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G3W89_RS02630 ENOG41082RQ UPF0102 protein G3W89_RS02635 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G3W89_RS02645 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W89_RS02650 ENOG4105CZX twitching motility protein G3W89_RS02655 ENOG4105CZX twitching motility protein G3W89_RS02660 ENOG4105DFA alanine racemase domain protein G3W89_RS02665 ENOG4105C26 Dehydrogenase G3W89_RS02670 ENOG4105D82 Glutamate dehydrogenase G3W89_RS02690 ENOG4105CYW agmatinase G3W89_RS02700 ENOG4105S7S phosphonate abc transporter G3W89_RS02705 ENOG4105D5T phosphonate abc transporter G3W89_RS02710 ENOG4105EHI Phosphonate ABC transporter, periplasmic G3W89_RS02715 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G3W89_RS02725 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) G3W89_RS02755 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G3W89_RS02770 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS02775 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G3W89_RS02790 ENOG41067MG lrgb family G3W89_RS02795 ENOG4105VAW lrga family G3W89_RS02800 ENOG4105CQB FAD linked oxidase domain protein G3W89_RS02810 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G3W89_RS02845 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G3W89_RS02895 ENOG4105CH2 amidohydrolase G3W89_RS02925 ENOG4105MH5 phosphoesterase PA-phosphatase related protein G3W89_RS02960 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) G3W89_RS02965 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G3W89_RS02970 ENOG4105CB5 ATP-dependent DNA helicase recG G3W89_RS02975 ENOG4105C5Q Transcriptional regulator G3W89_RS02985 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) G3W89_RS02990 ENOG4105II7 pyrroline-5-carboxylate reductase G3W89_RS02995 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) G3W89_RS03000 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) G3W89_RS03005 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits G3W89_RS03010 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G3W89_RS03015 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G3W89_RS03020 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G3W89_RS03025 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G3W89_RS03030 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G3W89_RS03035 ENOG4105VPB 50S ribosomal protein L30 G3W89_RS03040 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G3W89_RS03045 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G3W89_RS03055 ENOG41067V7 50S ribosomal protein L36 G3W89_RS03060 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G3W89_RS03065 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G3W89_RS03070 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G3W89_RS03075 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G3W89_RS03080 ENOG4108ZT0 50S ribosomal protein l17 G3W89_RS03100 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS03120 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G3W89_RS03135 ENOG4105EJC lysr family transcriptional regulator G3W89_RS03140 ENOG4105F6U Short-chain dehydrogenase reductase Sdr G3W89_RS03145 ENOG4105CPP Dehydrogenase, E1 component G3W89_RS03150 ENOG4107RUY (E1 component), alpha subunit G3W89_RS03195 ENOG4107R7Y intracellular protease Pfpi family G3W89_RS03205 ENOG4105DZS Phenylacetate-CoA ligase G3W89_RS03210 ENOG4108IV0 ABC, transporter G3W89_RS03230 ENOG4105C0Z ABC transporter G3W89_RS03235 ENOG4108IQE Amp-dependent synthetase and ligase G3W89_RS03240 ENOG4105IJJ transcriptional regulator, crp fnr family G3W89_RS03250 ENOG410904N short-chain dehydrogenase reductase G3W89_RS03270 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3W89_RS03275 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3W89_RS03280 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G3W89_RS03285 ENOG4105C08 Histidine kinase G3W89_RS03290 ENOG4105EEX Two component transcriptional regulator (Winged helix family G3W89_RS03295 ENOG4105FE9 pseudouridine synthase G3W89_RS03300 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3W89_RS03305 ENOG4105DHQ Histidine kinase G3W89_RS03355 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G3W89_RS03360 ENOG4106A3M Cytochrome p-450 G3W89_RS03365 ENOG4105E27 serine threonine protein kinase G3W89_RS03375 ENOG4108ZHJ Organic hydroperoxide resistance protein G3W89_RS03380 ENOG4105K56 Transcriptional regulator G3W89_RS03390 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W89_RS03395 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR G3W89_RS03415 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G3W89_RS03430 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS03440 ENOG4105C0Z ABC transporter G3W89_RS03445 ENOG4108IV0 ABC, transporter G3W89_RS03485 ENOG4107S78 Band 7 protein G3W89_RS03495 ENOG4105EQN UPF0261 protein G3W89_RS03500 ENOG4105C0Z ABC transporter G3W89_RS03520 ENOG4105CI2 imidazolone-5-propionate hydrolase G3W89_RS03525 ENOG4105CI2 imidazolone-5-propionate hydrolase G3W89_RS03530 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) G3W89_RS03535 ENOG4105ERH Fumarylacetoacetate hydrolase G3W89_RS03565 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) G3W89_RS03570 ENOG4109066 lysm domain bon superfamily protein G3W89_RS03580 ENOG4105CH5 extracellular solute-binding protein, family 7 G3W89_RS03590 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS03590 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS03625 ENOG4105DC8 reductase G3W89_RS03640 ENOG4105FYV Amp nucleosidase G3W89_RS03650 ENOG4108ZHR arsR family transcriptional regulator G3W89_RS03670 ENOG4105EJC lysr family transcriptional regulator G3W89_RS03675 ENOG4105CJ1 ABC, transporter G3W89_RS03690 ENOG4106BRA Membrane G3W89_RS03700 ENOG4105CH2 amidohydrolase G3W89_RS03715 ENOG4108J2R molybdopterin oxidoreductase G3W89_RS03775 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase G3W89_RS03780 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) G3W89_RS03785 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase G3W89_RS03805 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G3W89_RS03825 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G3W89_RS03835 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G3W89_RS03850 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G3W89_RS03905 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G3W89_RS03920 ENOG4105C0K Gdp-mannose 4,6-dehydratase G3W89_RS03935 ENOG4105C30 Nad-dependent epimerase dehydratase G3W89_RS03960 ENOG4105EXC Acyl-transferase G3W89_RS03985 ENOG4105CAS nag kinase G3W89_RS03995 ENOG4105CMR udp-glucose 4-epimerase G3W89_RS04015 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G3W89_RS04030 ENOG4105DZG Dehydrogenase G3W89_RS04035 ENOG4105IPI Membrane G3W89_RS04050 ENOG4108ZCF integral membrane protein G3W89_RS04065 ENOG4106P55 Transcriptional regulator G3W89_RS04075 ENOG4105CQB FAD linked oxidase domain protein G3W89_RS04085 ENOG4105MIR Phenylalanine 4-monooxygenase G3W89_RS04090 ENOG4105KZX Pterin carbinolamine dehydratase G3W89_RS04100 ENOG4105J0Q Transcriptional regulator G3W89_RS04110 ENOG4105CYM Glutathione S-transferase G3W89_RS04115 ENOG4105F95 Monooxygenase G3W89_RS04120 ENOG4105YVM Phosphoesterase, PA-phosphatase related G3W89_RS04135 ENOG4105BZU Histidine kinase G3W89_RS04140 ENOG4105DG4 malate L-lactate dehydrogenase G3W89_RS04145 ENOG4105CTX dehydratase G3W89_RS04150 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS04160 ENOG4108ERU trap dicarboxylate transporter subunit DctP G3W89_RS04165 ENOG4107YCY Transcriptional regulator G3W89_RS04170 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G3W89_RS04175 ENOG4106517 Short-chain dehydrogenase reductase Sdr G3W89_RS04185 ENOG4105C26 Dehydrogenase G3W89_RS04190 ENOG4105EXG Transcriptional regulator G3W89_RS04200 ENOG4105CSU acyl-Coa dehydrogenase G3W89_RS04215 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS04225 ENOG41060WC Enoyl-CoA hydratase G3W89_RS04230 ENOG4105NAU thioesterase Superfamily protein G3W89_RS04235 ENOG4108JJ7 ABC transporter G3W89_RS04240 ENOG4105C5I Dehydrogenase G3W89_RS04250 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS04255 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G3W89_RS04260 ENOG4105C0Z ABC transporter G3W89_RS04265 ENOG4108IV0 ABC, transporter G3W89_RS04275 ENOG4105RE0 Asp Glu hydantoin racemase G3W89_RS04290 ENOG4108UAU isochorismatase G3W89_RS04300 ENOG4107YNJ LysR family Transcriptional regulator G3W89_RS04305 ENOG4107RP9 extracellular solute-binding protein, family 3 G3W89_RS04310 ENOG4105EAD ABC transporter G3W89_RS04315 ENOG4105DRP amino acid AbC transporter G3W89_RS04320 ENOG4105CDA abc transporter atp-binding protein G3W89_RS04325 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W89_RS04330 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS04340 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS04345 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS04350 ENOG4105CC9 acyl-Coa dehydrogenase G3W89_RS04355 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS04360 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W89_RS04365 ENOG4105CBN LysR family transcriptional regulator G3W89_RS04370 ENOG4105EQ1 Transcriptional regulator G3W89_RS04375 ENOG4105CHJ isochorismatase hydrolase G3W89_RS04385 ENOG4105EFZ amidohydrolase G3W89_RS04405 ENOG4105W5Q DNA repair protein (RadC G3W89_RS04410 ENOG4105EKE dihydroorotase G3W89_RS04430 ENOG4108U57 Involved in the degradation of terephthalate (TPA) via the protocatechuate (PCA) 4,5-cleavage pathway. Catalyzes the dehydrogenation of 1,2-dihydroxy-3,5-cyclohexadiene-1,4- dicarboxylate (DCD) to yield protocatechuate (PCA) (By similarity) G3W89_RS04450 ENOG4107HP6 Transcriptional regulator G3W89_RS04455 ENOG4105D0M Protease HtpX homolog G3W89_RS04460 ENOG4105DZ0 fad dependent oxidoreductase G3W89_RS04465 ENOG4105BZU Histidine kinase G3W89_RS04470 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W89_RS04475 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W89_RS04485 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS04495 ENOG4105FE9 pseudouridine synthase G3W89_RS04500 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G3W89_RS04510 ENOG4107R0V Pyruvate dehydrogenase G3W89_RS04520 ENOG4105CPP Dehydrogenase, E1 component G3W89_RS04525 ENOG4107QSN dihydrolipoamide acetyltransferase G3W89_RS04535 ENOG4107QX8 SPFH domain, Band 7 family protein G3W89_RS04540 ENOG4105D7N magnesium and cobalt transport protein CorA G3W89_RS04555 ENOG4105DJ2 Major Facilitator Superfamily G3W89_RS04595 ENOG4105E1J oxidoreductase G3W89_RS04605 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G3W89_RS04620 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3W89_RS04625 ENOG4105DR4 Methyltransferase G3W89_RS04630 ENOG4105CKI cobalamin synthesis protein G3W89_RS04645 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) G3W89_RS04650 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) G3W89_RS04655 ENOG4108V6E Cell division protein mraZ G3W89_RS04660 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) G3W89_RS04665 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G3W89_RS04670 ENOG4105CJN penicillin-binding protein G3W89_RS04675 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G3W89_RS04680 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) G3W89_RS04685 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G3W89_RS04690 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G3W89_RS04695 ENOG4105CNI cell division protein FtsW G3W89_RS04700 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G3W89_RS04705 ENOG4105DFU Cell wall formation (By similarity) G3W89_RS04710 ENOG4105CPF Cell wall formation (By similarity) G3W89_RS04715 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) G3W89_RS04720 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G3W89_RS04725 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G3W89_RS04730 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3W89_RS04735 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G3W89_RS04750 ENOG4105K6V RNA polymerase G3W89_RS04770 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) G3W89_RS04775 ENOG4105KNE Phosphatidate cytidylyltransferase G3W89_RS04795 ENOG4105E2X shikimate dehydrogenase G3W89_RS04805 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) G3W89_RS04810 ENOG4105IPS esterase G3W89_RS04815 ENOG4105CNI cell division protein FtsW G3W89_RS04820 ENOG4105D1U peptidase U62 modulator of DNA gyrase G3W89_RS04825 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G3W89_RS04835 ENOG4105DFU Cell wall formation (By similarity) G3W89_RS04845 ENOG4107QX9 Thiol disulfide interChange protein G3W89_RS04850 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G3W89_RS04855 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G3W89_RS04860 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G3W89_RS04870 ENOG4107T4Z adenosine kinase G3W89_RS04880 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3W89_RS04885 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3W89_RS04895 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W89_RS04900 ENOG4107TUY Histidine kinase G3W89_RS04915 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G3W89_RS04920 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) G3W89_RS04925 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W89_RS04935 ENOG4107WP9 Histidine kinase G3W89_RS04940 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G3W89_RS04950 ENOG4105ENT Efflux transporter rnd family, mfp subunit G3W89_RS04955 ENOG4105BZS acriflavin resistance protein G3W89_RS04970 ENOG4107YAK holo-(acyl carrier protein) synthase 2 G3W89_RS04995 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) G3W89_RS05005 ENOG4105FGE Short-chain dehydrogenase reductase Sdr G3W89_RS05030 ENOG4105M0Y G3W89_RS05070 ENOG4105CHR reductase G3W89_RS05080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W89_RS05090 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase G3W89_RS05095 ENOG4105BZP glycoside hydrolase 15-related G3W89_RS05100 ENOG4108K4C ec 3.1.3.12 G3W89_RS05105 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G3W89_RS05110 ENOG4108RXX maleylacetoacetate isomerase G3W89_RS05115 ENOG4108302 MgtC SapB transporter G3W89_RS05120 ENOG4105E4C Lytic transglycosylase catalytic G3W89_RS05125 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G3W89_RS05130 ENOG4105ETT transcriptional Regulator, LysR family G3W89_RS05145 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G3W89_RS05165 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G3W89_RS05190 ENOG4105C10 Electron transfer flavoprotein G3W89_RS05225 ENOG4105HEI LysR family (Transcriptional regulator G3W89_RS05230 ENOG4108K01 transcriptional regulator G3W89_RS05235 ENOG4105D5G Transposase G3W89_RS05260 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G3W89_RS05290 ENOG4108Q35 Adenylate G3W89_RS05305 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS05315 ENOG4108M9J MaoC like domain protein G3W89_RS05320 ENOG4105CHR reductase G3W89_RS05330 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS05340 ENOG4105C0Z ABC transporter G3W89_RS05345 ENOG4108IV0 ABC, transporter G3W89_RS05350 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis G3W89_RS05370 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F G3W89_RS05380 ENOG4105CI0 Citrate lyase G3W89_RS05385 ENOG4108WYP Transcriptional regulator G3W89_RS05390 ENOG4107T8T UPF0173 metal-dependent hydrolase G3W89_RS05415 ENOG4105IKQ hydratase G3W89_RS05460 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS05480 ENOG4108NDG TRAP dicarboxylate G3W89_RS05490 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS05495 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G3W89_RS05520 ENOG4105C94 Transporter G3W89_RS05540 ENOG4105EMU Dehydrogenase G3W89_RS05545 ENOG4108M0I Transcriptional regulator G3W89_RS05555 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G3W89_RS05560 ENOG4108HR6 Dehydrogenase G3W89_RS05570 ENOG4105C7W Xanthine dehydrogenase G3W89_RS05575 ENOG4105CKI cobalamin synthesis protein G3W89_RS05590 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G3W89_RS05595 ENOG4105C2W permease G3W89_RS05600 ENOG4108JQ9 ABC transporter G3W89_RS05605 ENOG4105UIB (ABC) transporter G3W89_RS05625 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS05665 ENOG4105HEI LysR family (Transcriptional regulator G3W89_RS05670 ENOG4108RYK Nad-dependent epimerase dehydratase G3W89_RS05680 ENOG4105CH2 amidohydrolase G3W89_RS05685 ENOG4108RYR transcriptional regulator AsnC family G3W89_RS05715 ENOG4105CJP fad dependent oxidoreductase G3W89_RS05720 ENOG4108J59 Extracellular solute-binding protein, family 5 G3W89_RS05730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W89_RS05740 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3W89_RS05745 ENOG4105C26 Dehydrogenase G3W89_RS05750 ENOG4108DN8 FAD dependent oxidoreductase G3W89_RS05785 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W89_RS05795 ENOG4105CC0 LysR family Transcriptional regulator G3W89_RS05810 ENOG4105CS1 NAD(P)H quinone oxidoreductase G3W89_RS05830 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3W89_RS05840 ENOG4105CF7 AraC family transcriptional regulator G3W89_RS05845 ENOG4108MJI response regulator G3W89_RS05865 ENOG4105JGF anti-sigma regulatory factor serine threonine protein kinase G3W89_RS05920 ENOG4105DS1 cytochrome b561 G3W89_RS05925 ENOG4105EQ0 Major Facilitator superfamily G3W89_RS05930 ENOG4105HEI LysR family (Transcriptional regulator G3W89_RS05945 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) G3W89_RS05950 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G3W89_RS05965 ENOG4105CG3 alpha amylase, catalytic region G3W89_RS05970 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) G3W89_RS05975 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G3W89_RS06005 ENOG4105BZ1 (ABC) transporter G3W89_RS06015 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G3W89_RS06020 ENOG4105CQ0 ABC transporter G3W89_RS06030 ENOG4105D7Q type ii secretion system G3W89_RS06040 ENOG4107QHF type ii secretion system protein e G3W89_RS06060 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) G3W89_RS06085 ENOG4108VAU general secretion pathway protein G G3W89_RS06095 ENOG4105C7B Threonine dehydratase G3W89_RS06100 ENOG4108UKZ OsmC family G3W89_RS06105 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) G3W89_RS06110 ENOG4108Z9W Outer membrane porin G3W89_RS06120 ENOG4105CH2 amidohydrolase G3W89_RS06125 ENOG4108J59 Extracellular solute-binding protein, family 5 G3W89_RS06130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W89_RS06135 ENOG4105C3U ABC transporter G3W89_RS06140 ENOG4108JQ7 (ABC) transporter G3W89_RS06145 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G3W89_RS06160 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G3W89_RS06165 ENOG4107QP8 phosphohexose isomerase G3W89_RS06175 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G3W89_RS06180 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) G3W89_RS06185 ENOG4105CHB tonB-dependent Receptor G3W89_RS06195 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G3W89_RS06205 ENOG4105D1S lipid A biosynthesis G3W89_RS06210 ENOG4105D74 hydrolase G3W89_RS06215 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) G3W89_RS06230 ENOG4105CRE cytochrome C G3W89_RS06235 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G3W89_RS06240 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) G3W89_RS06245 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G3W89_RS06255 ENOG4105XQ6 frataxin-like protein G3W89_RS06260 ENOG4108JQC penicillin-binding protein 1A G3W89_RS06285 ENOG4105E4G Type IV pilus G3W89_RS06290 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G3W89_RS06300 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein G3W89_RS06335 ENOG4105DHJ ABC, transporter G3W89_RS06340 ENOG4105CY3 ABC transporter, permease G3W89_RS06345 ENOG4107PE3 Mammalian cell entry related domain protein G3W89_RS06365 ENOG4105DA5 (ABC) transporter G3W89_RS06370 ENOG4105E3A (ABC) transporter G3W89_RS06375 ENOG4105VFK BolA family G3W89_RS06380 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G3W89_RS06385 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G3W89_RS06400 ENOG4105CIH Imidazole acetol-phosphate transaminase G3W89_RS06405 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G3W89_RS06415 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G3W89_RS06425 ENOG4105DSB aldose 1-epimerase G3W89_RS06430 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G3W89_RS06435 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G3W89_RS06440 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase G3W89_RS06450 ENOG4107YU2 histidine triad (hIT) protein G3W89_RS06455 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G3W89_RS06460 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G3W89_RS06465 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G3W89_RS06470 ENOG4105C0H protease G3W89_RS06475 ENOG4107QNR UPF0135 protein G3W89_RS06480 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G3W89_RS06485 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G3W89_RS06490 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G3W89_RS06495 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G3W89_RS06500 ENOG4105EIX cytochrome c1 G3W89_RS06505 ENOG4107MKT Stringent starvation protein a G3W89_RS06510 ENOG4105KB2 stringent starvation protein b G3W89_RS06535 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G3W89_RS06540 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G3W89_RS06550 ENOG4105M6F mutator MutT protein G3W89_RS06555 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) G3W89_RS06570 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein G3W89_RS06590 ENOG4107QHF type ii secretion system protein e G3W89_RS06600 ENOG4108KMV Glycosyl transferase (Group 1 G3W89_RS06615 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G3W89_RS06635 ENOG4105DZ1 carboxypeptidase G3W89_RS06640 ENOG4105C6Y Udp-glucose 6-dehydrogenase G3W89_RS06650 ENOG4106WTF Glycosyl transferase, family 2 G3W89_RS06655 ENOG4105CH7 arginosuccinase G3W89_RS06660 ENOG4108HRK Histidine kinase G3W89_RS06665 ENOG4108NEV two component transcriptional regulator, LytTR family G3W89_RS06670 ENOG4105DSF transport protein G3W89_RS06680 ENOG4105CSH Transporter G3W89_RS06700 ENOG4105DIA mandelate racemase muconate lactonizing G3W89_RS06715 ENOG4105HSS phospholipase C G3W89_RS06720 ENOG4105BZ4 penicillin-binding protein G3W89_RS06730 ENOG4105KA0 thioesterase Superfamily protein G3W89_RS06745 ENOG4105EAH synthase G3W89_RS06750 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) G3W89_RS06755 ENOG4105K46 50S ribosomal protein l27 G3W89_RS06760 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G3W89_RS06765 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G3W89_RS06775 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G3W89_RS06780 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G3W89_RS06785 ENOG4105E4C Lytic transglycosylase catalytic G3W89_RS06790 ENOG4105C37 (CBS) domain G3W89_RS06795 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G3W89_RS06810 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G3W89_RS06815 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G3W89_RS06820 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G3W89_RS06830 ENOG4105EGS Mechanosensitive ion channel G3W89_RS06835 ENOG4107T6V glycerophosphoryl diester phosphodiesterase G3W89_RS06840 ENOG4108IJ9 (ABC) transporter G3W89_RS06850 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component G3W89_RS06860 ENOG4108JQ1 Dehydrogenase G3W89_RS06880 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3W89_RS06895 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) G3W89_RS06900 ENOG4108IA2 Sodium pantothenate symporter G3W89_RS06915 ENOG4105C9M aspartyl-trna synthetase G3W89_RS06920 ENOG4108TIT dATP pyrophosphohydrolase G3W89_RS06925 ENOG4105X23 Endonuclease Exonuclease phosphatase G3W89_RS06930 ENOG4105EUJ GTP cyclohydrolase i G3W89_RS06970 ENOG4105BZU Histidine kinase G3W89_RS06975 ENOG4105WH1 Two component transcriptional regulator luxr family G3W89_RS06995 ENOG4105D06 uba thif-type nad fad binding protein G3W89_RS07000 ENOG4105CN1 protease G3W89_RS07005 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G3W89_RS07010 ENOG4105WZW rhodanese family G3W89_RS07020 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) G3W89_RS07025 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G3W89_RS07030 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G3W89_RS07035 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G3W89_RS07040 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G3W89_RS07045 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) G3W89_RS07050 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) G3W89_RS07055 ENOG4108IYU L-aspartate oxidase G3W89_RS07080 ENOG4105CHH sulfate transporter G3W89_RS07090 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G3W89_RS07095 ENOG4108YXG UPF0502 protein G3W89_RS07100 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit G3W89_RS07105 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W89_RS07110 ENOG4108JPZ Monovalent cation H antiporter subunit D G3W89_RS07120 ENOG4107TDF Formate hydrogenlyase subunit 4 G3W89_RS07125 ENOG4108JPZ Monovalent cation H antiporter subunit D G3W89_RS07155 ENOG4105C5Q Transcriptional regulator G3W89_RS07170 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G3W89_RS07180 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) G3W89_RS07215 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G3W89_RS07220 ENOG4105QAX Iron-sulfur G3W89_RS07240 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G3W89_RS07245 ENOG4105CV6 ABC transporter, permease G3W89_RS07255 ENOG4105C28 cystathionine G3W89_RS07275 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G3W89_RS07280 ENOG4108RAC Rubrerythrin G3W89_RS07295 ENOG4105DRP amino acid AbC transporter G3W89_RS07300 ENOG4105EAD ABC transporter G3W89_RS07305 ENOG4107RP9 extracellular solute-binding protein, family 3 G3W89_RS07320 ENOG4105W5Q DNA repair protein (RadC G3W89_RS07325 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase G3W89_RS07330 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G3W89_RS07335 ENOG4105C7B Threonine dehydratase G3W89_RS07345 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G3W89_RS07370 ENOG4105CHR reductase G3W89_RS07375 ENOG4105CJW magnesium transporter G3W89_RS07380 ENOG4107R1Y fructose-bisphosphate aldolase G3W89_RS07385 ENOG4105C7I Dehydrogenase G3W89_RS07395 ENOG4105BZU Histidine kinase G3W89_RS07405 ENOG4105C31 Tryptophanyl-tRNA synthetase G3W89_RS07410 ENOG4108Z4T Peptidase M50 G3W89_RS07415 ENOG4107RTD sua5 ycio yrdc ywlc family protein G3W89_RS07425 ENOG4105DB7 PHP domain protein G3W89_RS07430 ENOG4105CSR polyphosphate kinase 2 G3W89_RS07445 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein G3W89_RS07450 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS07460 ENOG4105C0Z ABC transporter G3W89_RS07465 ENOG4108IV0 ABC, transporter G3W89_RS07475 ENOG4105CDA abc transporter atp-binding protein G3W89_RS07490 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3W89_RS07500 ENOG4105E5Q amino acid AbC transporter G3W89_RS07515 ENOG41079KZ Major Facilitator Superfamily G3W89_RS07520 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G3W89_RS07525 ENOG4108Z6B deaminase G3W89_RS07530 ENOG4105CC9 acyl-Coa dehydrogenase G3W89_RS07540 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS07545 ENOG4108UKI Enoyl-CoA hydratase G3W89_RS07555 ENOG4108UKI Enoyl-CoA hydratase G3W89_RS07560 ENOG4108WYP Transcriptional regulator G3W89_RS07565 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS07570 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS07575 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W89_RS07580 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS07620 ENOG4105C0Z ABC transporter G3W89_RS07625 ENOG4108IV0 ABC, transporter G3W89_RS07630 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS07635 ENOG4105CC9 acyl-Coa dehydrogenase G3W89_RS07640 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS07675 ENOG4105EYW Ion transport protein G3W89_RS07710 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold G3W89_RS07780 ENOG4107UXM Membrane G3W89_RS07795 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W89_RS07810 ENOG4105C6K Malic enzyme G3W89_RS07840 ENOG4105CJ2 (LipO)protein G3W89_RS07845 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G3W89_RS07855 ENOG4107E2E PKHD-type hydroxylase G3W89_RS07860 ENOG4105BZU Histidine kinase G3W89_RS07885 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3W89_RS07895 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G3W89_RS07900 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS07950 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G3W89_RS07970 ENOG4105BZU Histidine kinase G3W89_RS07980 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) G3W89_RS08040 ENOG4105EEX Two component transcriptional regulator (Winged helix family G3W89_RS08045 ENOG4105DFH Transport of potassium into the cell (By similarity) G3W89_RS08050 ENOG4105DFH Transport of potassium into the cell (By similarity) G3W89_RS08060 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS08065 ENOG4105CYC Transferase G3W89_RS08070 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G3W89_RS08085 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS08090 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS08145 ENOG4105FDP GntR family transcriptional regulator G3W89_RS08155 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W89_RS08160 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W89_RS08185 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS08195 ENOG4105C0Z ABC transporter G3W89_RS08200 ENOG4108IV0 ABC, transporter G3W89_RS08245 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) G3W89_RS08280 ENOG4107SFQ iron-sulfur binding G3W89_RS08300 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W89_RS08305 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ G3W89_RS08310 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS08315 ENOG4105EEQ Na H antiporter G3W89_RS08325 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G3W89_RS08330 ENOG4108WUH Transcriptional regulator, TetR family G3W89_RS08340 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS08350 ENOG4107QNJ CoA-transferase subunit B G3W89_RS08360 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) G3W89_RS08380 ENOG4108JQ7 (ABC) transporter G3W89_RS08390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W89_RS08425 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W89_RS08430 ENOG4107YNJ LysR family Transcriptional regulator G3W89_RS08435 ENOG4105CMJ mandelate racemase muconate lactonizing G3W89_RS08445 ENOG4106FTQ Taurine ABC transporter, periplasmic G3W89_RS08455 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W89_RS08460 ENOG4105CYM Glutathione S-transferase G3W89_RS08470 ENOG4105CSH Transporter G3W89_RS08475 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G3W89_RS08480 ENOG4108FUF Transcriptional regulator, IclR family G3W89_RS08505 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS08510 ENOG4105CD5 CoA-binding domain protein G3W89_RS08530 ENOG4105HEI LysR family (Transcriptional regulator G3W89_RS08540 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS08545 ENOG4108EKI Dehydrogenase G3W89_RS08630 ENOG4105WH1 Two component transcriptional regulator luxr family G3W89_RS08650 ENOG4108FUF Transcriptional regulator, IclR family G3W89_RS08665 ENOG4105DUM transcriptional regulator, lysR family G3W89_RS08670 ENOG4105DB1 molybdopterin oxidoreductase G3W89_RS08675 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G3W89_RS08680 ENOG4108KDI dmso reductase anchor subunit G3W89_RS08695 ENOG4105CPQ Dehydrogenase G3W89_RS08700 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G3W89_RS08715 ENOG4107RZC phospholipase d G3W89_RS08740 ENOG4108JU3 Alkyl hydroperoxide reductase G3W89_RS08755 ENOG41082BM Transcriptional regulator, arsr family G3W89_RS08765 ENOG4107QVM von Willebrand factor, type A G3W89_RS08795 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) G3W89_RS08800 ENOG4108ZC9 flagellar basal-body rod protein flgc G3W89_RS08805 ENOG4105W00 Flagellar hook capping protein G3W89_RS08810 ENOG4105BZE flagellar hook protein, FlgE G3W89_RS08815 ENOG4108KPB Flagellar basal-body rod protein FlgF G3W89_RS08820 ENOG4105CGA flagellar basal-body rod protein FlgG G3W89_RS08835 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj G3W89_RS08840 ENOG4105C8Q Methyl-accepting chemotaxis G3W89_RS08845 ENOG4108V3W Chemotaxis protein, CheW G3W89_RS08850 ENOG4105C8Q Methyl-accepting chemotaxis G3W89_RS08855 ENOG4105C8Q Methyl-accepting chemotaxis G3W89_RS08860 ENOG4105C8Q Methyl-accepting chemotaxis G3W89_RS08865 ENOG4105C8Q Methyl-accepting chemotaxis G3W89_RS08870 ENOG4105E1Q flagellar hook-associated protein G3W89_RS08875 ENOG4105DTJ flagellar hook-associated protein G3W89_RS08910 ENOG4108SVW integral membrane protein G3W89_RS08920 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G3W89_RS08955 ENOG4105E0F Histidine kinase G3W89_RS08965 ENOG4105EXG Transcriptional regulator G3W89_RS08970 ENOG4105CHR reductase G3W89_RS08990 ENOG4105D19 Role in flagellar biosynthesis (By similarity) G3W89_RS08995 ENOG4105VS8 Flagellar biosynthetic protein fliq G3W89_RS09000 ENOG4105CN7 Flagellar biosynthetic protein FliP G3W89_RS09010 ENOG4105DD5 Flagellar motor switch protein G3W89_RS09015 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G3W89_RS09020 ENOG4107ZI8 flagellar basal body-associated protein flil G3W89_RS09025 ENOG4105WF4 Flagellar hook-length control protein G3W89_RS09030 ENOG4105GSA Flagellar export protein flij G3W89_RS09035 ENOG4108JIR Flagellum-specific ATP synthase G3W89_RS09040 ENOG4108CG0 Flagellar assembly protein G3W89_RS09045 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G3W89_RS09050 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) G3W89_RS09065 ENOG4105DTS flagellar hook-associated G3W89_RS09070 ENOG4105MQ3 flagellar protein FliS G3W89_RS09095 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region G3W89_RS09100 ENOG4107RD7 Flagellar Motor Protein, MotA G3W89_RS09105 ENOG4105ER2 Ompa motb domain protein G3W89_RS09110 ENOG4105CBS Chea signal transduction histidine kinase G3W89_RS09115 ENOG4105D58 Diguanylate phosphodiesterase G3W89_RS09120 ENOG4105BZU Histidine kinase G3W89_RS09140 ENOG4108VYJ response regulator receiver protein G3W89_RS09145 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) G3W89_RS09150 ENOG4105D00 flagellar biosynthetic protein flhB G3W89_RS09155 ENOG4105D7B Flagellar biosynthesis protein flha G3W89_RS09160 ENOG4105FZW flagellar biosynthesis regulator FlhF G3W89_RS09170 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W89_RS09185 ENOG4105TV9 FHA Domain-Containing protein G3W89_RS09195 ENOG4108TQ9 Histidine kinase G3W89_RS09200 ENOG4108S01 response regulator G3W89_RS09225 ENOG4105BZU Histidine kinase G3W89_RS09370 ENOG4105EMN RNA polymerase sigma factor G3W89_RS09420 ENOG4105WH1 Two component transcriptional regulator luxr family G3W89_RS09430 ENOG4105BZU Histidine kinase G3W89_RS09450 ENOG4105C5I Dehydrogenase G3W89_RS09455 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3W89_RS09495 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 G3W89_RS09500 ENOG4105CD8 aminopeptidase N G3W89_RS09515 ENOG4105CPC Aldo Keto reductase G3W89_RS09520 ENOG4108Z66 YbaK ebsC protein G3W89_RS09525 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) G3W89_RS09530 ENOG4105M4H endoribonuclease L-psp G3W89_RS09540 ENOG4108VPT UPF0234 protein G3W89_RS09545 ENOG4105D4A Cell wall formation (By similarity) G3W89_RS09550 ENOG4105CDH Citrulline--aspartate ligase G3W89_RS09555 ENOG4105NBK UPF0345 protein G3W89_RS09565 ENOG4105KUZ arsenate reductase G3W89_RS09570 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G3W89_RS09585 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase G3W89_RS09590 ENOG4105C28 cystathionine G3W89_RS09595 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G3W89_RS09625 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W89_RS09665 ENOG4108JUA Transcriptional regulator G3W89_RS09675 ENOG4105K63 Thioredoxin G3W89_RS09695 ENOG4105C3M thioredoxin reductase G3W89_RS09700 ENOG4105D0M Protease HtpX homolog G3W89_RS09705 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W89_RS09710 ENOG4105ECQ AraC Family Transcriptional Regulator G3W89_RS09715 ENOG4105K3G Periplasmic Protein G3W89_RS09725 ENOG4105VN1 Heat shock protein G3W89_RS09735 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3W89_RS09740 ENOG4105BZU Histidine kinase G3W89_RS09745 ENOG4105DRR Transcriptional regulator, GntR family G3W89_RS09760 ENOG4105CTX dehydratase G3W89_RS09775 ENOG41083Z3 extracellular ligand-binding receptor G3W89_RS09790 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS09795 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G3W89_RS09800 ENOG4105C0Z ABC transporter G3W89_RS09805 ENOG4108IV0 ABC, transporter G3W89_RS09840 ENOG4105C7W Xanthine dehydrogenase G3W89_RS09850 ENOG4105C7N Xanthine uracil vitamin C permease G3W89_RS09855 ENOG4108JQ9 ABC transporter G3W89_RS09860 ENOG4105UIB (ABC) transporter G3W89_RS09880 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3W89_RS09890 ENOG4105BZU Histidine kinase G3W89_RS09895 ENOG4107QHF type ii secretion system protein e G3W89_RS09900 ENOG4105BZU Histidine kinase G3W89_RS09915 ENOG4108TJN glycosyl transferase group 1 G3W89_RS09920 ENOG4107QUY Guanine deaminase G3W89_RS09925 ENOG4105DHP deoxycytidine triphosphate deaminase G3W89_RS09930 ENOG4105CGZ zinc metallopeptidase G3W89_RS09935 ENOG4105C1J atp-dependent rna helicase G3W89_RS09940 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) G3W89_RS09945 ENOG4105EE5 Membrane protein terC G3W89_RS09970 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W89_RS09975 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3W89_RS09980 ENOG41060W2 glyoxylate carboligase G3W89_RS09985 ENOG4105CC0 LysR family Transcriptional regulator G3W89_RS10040 ENOG4107YCY Transcriptional regulator G3W89_RS10045 ENOG4105CK2 sodium dicarboxylate symporter G3W89_RS10055 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS10060 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W89_RS10075 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS10080 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS10105 ENOG4105C3M thioredoxin reductase G3W89_RS10135 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme G3W89_RS10140 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G3W89_RS10155 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS10160 ENOG4105E7U AraC family transcriptional regulator G3W89_RS10180 ENOG4105CPQ Dehydrogenase G3W89_RS10185 ENOG4105CHR reductase G3W89_RS10195 ENOG4105JSC dimethylmenaquinone methyltransferase G3W89_RS10210 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G3W89_RS10215 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G3W89_RS10220 ENOG4105P4J Allophanate hydrolase, subunit 1 G3W89_RS10225 ENOG4107R7A Allophanate hydrolase subunit 2 G3W89_RS10245 ENOG4108HW4 amino acid AbC transporter G3W89_RS10250 ENOG4105DRP amino acid AbC transporter G3W89_RS10255 ENOG4105CDA abc transporter atp-binding protein G3W89_RS10260 ENOG4106PMH Extracellular solute-binding protein family 3 G3W89_RS10275 ENOG4105DTQ mandelate racemase muconate lactonizing G3W89_RS10305 ENOG41060NJ transcriptional regulator G3W89_RS10320 ENOG4105EN6 Membrane G3W89_RS10330 ENOG4105EXW epimerase dehydratase G3W89_RS10335 ENOG4108KWP DNA-binding transcriptional regulator GlcC G3W89_RS10355 ENOG4105EG2 ABC transporter, permease G3W89_RS10365 ENOG4105ETT transcriptional Regulator, LysR family G3W89_RS10370 ENOG4105KME endoribonuclease L-psp G3W89_RS10390 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3W89_RS10400 ENOG4105F38 ABC transporter, permease G3W89_RS10435 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W89_RS10460 ENOG4105C7W Xanthine dehydrogenase G3W89_RS10465 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding G3W89_RS10470 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit G3W89_RS10475 ENOG4105ECQ AraC Family Transcriptional Regulator G3W89_RS10480 ENOG4105F27 Major Facilitator G3W89_RS10485 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3W89_RS10500 ENOG4105EJC lysr family transcriptional regulator G3W89_RS10510 ENOG4105CV8 reductase G3W89_RS10515 ENOG4105C2W permease G3W89_RS10545 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein G3W89_RS10550 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G3W89_RS10565 ENOG4107YCY Transcriptional regulator G3W89_RS10605 ENOG4105CJ1 ABC, transporter G3W89_RS10610 ENOG4107QWP ABC-2 type transporter G3W89_RS10615 ENOG4107QWP ABC-2 type transporter G3W89_RS10675 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein G3W89_RS10700 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS10705 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W89_RS10710 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase G3W89_RS10825 ENOG4105CDV Ompa motb domain protein G3W89_RS10875 ENOG4105EMN RNA polymerase sigma factor G3W89_RS10880 ENOG4108K2P TRANSCRIPTIONal G3W89_RS10885 ENOG4105C5I Dehydrogenase G3W89_RS10900 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS10915 ENOG4105C59 p-type ATPase G3W89_RS10925 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G3W89_RS10940 ENOG4107RT3 EamA-like transporter family G3W89_RS10955 ENOG4107QKV phosphomannomutase G3W89_RS10960 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase G3W89_RS10995 ENOG4108KE4 O-methyltransferase G3W89_RS11005 ENOG4105ENT Efflux transporter rnd family, mfp subunit G3W89_RS11010 ENOG4105YA8 Transcriptional regulator G3W89_RS11015 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G3W89_RS11030 ENOG4105CFH Aspartokinase G3W89_RS11035 ENOG4105CPC Aldo Keto reductase G3W89_RS11045 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G3W89_RS11070 ENOG4105C01 Dihydroxy-acid dehydratase G3W89_RS11075 ENOG4108UHU Aldolase G3W89_RS11085 ENOG4108UYE Lactoylglutathione lyase G3W89_RS11105 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS11110 ENOG4105EA8 2-Nitropropane dioxygenase G3W89_RS11115 ENOG4107GJV short-chain dehydrogenase reductase G3W89_RS11125 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS11130 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G3W89_RS11135 ENOG4105CHR reductase G3W89_RS11150 ENOG4105DIQ Transcriptional regulator G3W89_RS11155 ENOG4107TTA Xylose isomerase domain protein TIM barrel G3W89_RS11175 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W89_RS11180 ENOG4105D7K pfkb domain protein G3W89_RS11215 ENOG4105CHR reductase G3W89_RS11230 ENOG4108RTU Aldolase G3W89_RS11240 ENOG4105C01 Dihydroxy-acid dehydratase G3W89_RS11245 ENOG4107EJG GntR family transcriptional regulator G3W89_RS11255 ENOG4105D56 permease protein G3W89_RS11270 ENOG4106IPI cyclase, family G3W89_RS11290 ENOG4107EPV Aminotransferase class V G3W89_RS11300 ENOG4105C1J atp-dependent rna helicase G3W89_RS11305 ENOG4105C5H ABC transporter G3W89_RS11340 ENOG4108JJA ABC, transporter G3W89_RS11355 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS11360 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS11370 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W89_RS11375 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS11385 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS11390 ENOG4107QX3 carboxylase G3W89_RS11415 ENOG4108KB1 transcriptional regulator, arac family G3W89_RS11425 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS11435 ENOG4107QX3 carboxylase G3W89_RS11440 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G3W89_RS11450 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS11460 ENOG4105C0Z ABC transporter G3W89_RS11465 ENOG4108IV0 ABC, transporter G3W89_RS11480 ENOG4107QX3 carboxylase G3W89_RS11490 ENOG4105KXX peptidase s58 dmpa G3W89_RS11500 ENOG4105W1Y Transcriptional regulator G3W89_RS11520 ENOG4108Z9K Osmotically inducible protein G3W89_RS11525 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS11545 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase G3W89_RS11550 ENOG4105CEP NADH dehydrogenase G3W89_RS11555 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G3W89_RS11560 ENOG41067HS methyltransferase G3W89_RS11575 ENOG41081QV Universal stress protein G3W89_RS11585 ENOG4105BZU Histidine kinase G3W89_RS11620 ENOG4105D3G Pseudouridine synthase G3W89_RS11640 ENOG4105CKW Inner membrane protein yedI G3W89_RS11645 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) G3W89_RS11655 ENOG4105F4K antigen 43 G3W89_RS11680 ENOG4106CJB Phospholipase Carboxylesterase G3W89_RS11685 ENOG4105D9M gamma-glutamylcysteine synthetase G3W89_RS11690 ENOG4107QWB Ornithine cyclodeaminase G3W89_RS11695 ENOG4108UYB regulatoR G3W89_RS11700 ENOG4105F0I Aminotransferase G3W89_RS11710 ENOG4108VAC response regulator G3W89_RS11715 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) G3W89_RS11745 ENOG4107XZC Restriction modification system DNA (Specificity G3W89_RS11760 ENOG4105CX6 glutaminyL-tRNA synthetase G3W89_RS11770 ENOG4108VAC response regulator G3W89_RS11775 ENOG4108HRK Histidine kinase G3W89_RS11790 ENOG4105ENT Efflux transporter rnd family, mfp subunit G3W89_RS11795 ENOG4105BZS acriflavin resistance protein G3W89_RS11805 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3W89_RS11835 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G3W89_RS11865 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) G3W89_RS11875 ENOG41061MV Arylsulfatase G3W89_RS11880 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS11890 ENOG4108VHT MarR family transcriptional regulator G3W89_RS11900 ENOG4105DDW LysR family Transcriptional regulator G3W89_RS11915 ENOG4105ECY inositol monophosphatase G3W89_RS11925 ENOG4105D7W serine acetyltransferase G3W89_RS11930 ENOG4108RIR Molybdenum cofactor biosynthesis protein G3W89_RS11935 ENOG4105N42 UPF0307 protein G3W89_RS11940 ENOG4105CMS peptidase U62, modulator of DNA gyrase G3W89_RS11950 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G3W89_RS11955 ENOG4105KTH gatB Yqey G3W89_RS11960 ENOG4105VCC 30S ribosomal protein S21 G3W89_RS11965 ENOG4105CBX hi0933 family G3W89_RS11975 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G3W89_RS11980 ENOG4108MTB glycosyl transferase family G3W89_RS11995 ENOG4108IFG nitrite reductase, (NAD(P)H) G3W89_RS12000 ENOG4105D9P serine threonine protein kinase G3W89_RS12015 ENOG4105D7T ABC transporter G3W89_RS12025 ENOG4105I5W Transporter G3W89_RS12035 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G3W89_RS12050 ENOG4105ES9 amino acid G3W89_RS12055 ENOG4105CHM Aminotransferase G3W89_RS12060 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G3W89_RS12065 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G3W89_RS12075 ENOG4105CP7 Triose-phosphate isomerase G3W89_RS12080 ENOG4107EJC Preprotein translocase subunit SecG G3W89_RS12090 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G3W89_RS12095 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W89_RS12100 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G3W89_RS12105 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W89_RS12115 ENOG4107QIZ NADH dehydrogenase G3W89_RS12120 ENOG4108IEH NADH dehydrogenase subunit g G3W89_RS12125 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) G3W89_RS12130 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W89_RS12135 ENOG4105DF2 NADH dehydrogenase subunit j G3W89_RS12140 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W89_RS12150 ENOG4105C8S subunit m G3W89_RS12155 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W89_RS12165 ENOG4108YZ4 nudix hydrolase G3W89_RS12185 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS12195 ENOG4105CFM UPF0317 protein G3W89_RS12215 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) G3W89_RS12220 ENOG4105C26 Dehydrogenase G3W89_RS12225 ENOG4105C7K acetolactate synthase G3W89_RS12230 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS12235 ENOG4105CM2 brancheD-chain amino acid aminotransferase G3W89_RS12245 ENOG4105BZ1 (ABC) transporter G3W89_RS12250 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G3W89_RS12260 ENOG4105CW7 secretion protein, HlyD family G3W89_RS12265 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3W89_RS12270 ENOG4105C0Z ABC transporter G3W89_RS12275 ENOG4108IV0 ABC, transporter G3W89_RS12290 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS12305 ENOG4105VFU Rna-binding protein G3W89_RS12315 ENOG4105ETT transcriptional Regulator, LysR family G3W89_RS12320 ENOG4105DRR Transcriptional regulator, GntR family G3W89_RS12335 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G3W89_RS12350 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W89_RS12360 ENOG4105CSH Transporter G3W89_RS12370 ENOG4108SHN Glycosyl transferase, family 2 G3W89_RS12410 ENOG4105GRZ Ycii-related protein G3W89_RS12415 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W89_RS12430 ENOG4105JXH GntR family transcriptional regulator G3W89_RS12445 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS12450 ENOG4105EXG Transcriptional regulator G3W89_RS12455 ENOG4105CG3 alpha amylase, catalytic region G3W89_RS12460 ENOG4107QK4 glycoside hydrolase, family 3 domain protein G3W89_RS12475 ENOG4105CQ0 ABC transporter G3W89_RS12495 ENOG4105CHR reductase G3W89_RS12500 ENOG4105C5Q Transcriptional regulator G3W89_RS12505 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3W89_RS12510 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G3W89_RS12520 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate G3W89_RS12530 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS12535 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W89_RS12540 ENOG4105ETE Transcriptional regulator (LacI family G3W89_RS12550 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G3W89_RS12555 ENOG4105DQR SNARE associated Golgi G3W89_RS12570 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G3W89_RS12575 ENOG4105K8N protein family UPF0079, ATPase G3W89_RS12580 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G3W89_RS12600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3W89_RS12615 ENOG4105ED9 Protein of unknown function (DUF455) G3W89_RS12620 ENOG4108Z0R Transferase G3W89_RS12625 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) G3W89_RS12640 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G3W89_RS12645 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G3W89_RS12650 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase G3W89_RS12655 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G3W89_RS12660 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G3W89_RS12670 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G3W89_RS12680 ENOG4108YZY peptidylprolyl cis-trans isomerase G3W89_RS12685 ENOG4105EZE Cupin 4 family protein G3W89_RS12700 ENOG4105Q2H domain protein G3W89_RS12705 ENOG4105GJM (LipO)protein G3W89_RS12710 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3W89_RS12725 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W89_RS12735 ENOG4105EMN RNA polymerase sigma factor G3W89_RS12740 ENOG4105E4C Lytic transglycosylase catalytic G3W89_RS12745 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W89_RS12765 ENOG4105C26 Dehydrogenase G3W89_RS12790 ENOG4105C5Q Transcriptional regulator G3W89_RS12795 ENOG4107QPD alcohol dehydrogenase G3W89_RS12805 ENOG4108IV0 ABC, transporter G3W89_RS12810 ENOG4105C0Z ABC transporter G3W89_RS12845 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G3W89_RS12855 ENOG4105E5Q amino acid AbC transporter G3W89_RS12860 ENOG4105E5Q amino acid AbC transporter G3W89_RS12865 ENOG4105EAB amino acid AbC transporter G3W89_RS12870 ENOG4105CDA abc transporter atp-binding protein G3W89_RS12880 ENOG4105D7K pfkb domain protein G3W89_RS12890 ENOG4108M60 Transcriptional regulator G3W89_RS12905 ENOG4107RTG Major Facilitator superfamily G3W89_RS12915 ENOG4108UYU AsnC family transcriptional regulator G3W89_RS12940 ENOG4108EC8 DNA internalization-related competence protein ComEC G3W89_RS12970 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G3W89_RS12975 ENOG4105E98 transcriptional regulator DeoR family G3W89_RS12980 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G3W89_RS12985 ENOG4108IJ9 (ABC) transporter G3W89_RS12990 ENOG4108IJ9 (ABC) transporter G3W89_RS13000 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component G3W89_RS13020 ENOG4105CVE Lytic murein transglycosylase G3W89_RS13025 ENOG4105F8C transglutaminase domain-containing protein G3W89_RS13035 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G3W89_RS13040 ENOG4105DGU Histone deacetylase G3W89_RS13045 ENOG4105EGS Mechanosensitive ion channel G3W89_RS13050 ENOG4105BZJ Electron transfer flavoprotein G3W89_RS13055 ENOG4105C10 Electron transfer flavoprotein G3W89_RS13060 ENOG4105CSU acyl-Coa dehydrogenase G3W89_RS13080 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G3W89_RS13085 ENOG4105C4M (Ubiquinol oxidase) subunit I G3W89_RS13095 ENOG4105BZU Histidine kinase G3W89_RS13115 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G3W89_RS13120 ENOG4105C6X Major Facilitator G3W89_RS13125 ENOG4105CSH Transporter G3W89_RS13135 ENOG4107HP6 Transcriptional regulator G3W89_RS13140 ENOG4105E2X shikimate dehydrogenase G3W89_RS13150 ENOG4105E2X shikimate dehydrogenase G3W89_RS13155 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G3W89_RS13190 ENOG4105EGI Transcriptional regulator G3W89_RS13195 ENOG4105CBP Major Facilitator G3W89_RS13220 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G3W89_RS13230 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G3W89_RS13235 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G3W89_RS13240 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G3W89_RS13250 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS13260 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W89_RS13265 ENOG4105EXW epimerase dehydratase G3W89_RS13275 ENOG4105C0Z ABC transporter G3W89_RS13280 ENOG4108IV0 ABC, transporter G3W89_RS13285 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS13290 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G3W89_RS13300 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3W89_RS13315 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G3W89_RS13320 ENOG4105CHR reductase G3W89_RS13335 ENOG4105DHQ Histidine kinase G3W89_RS13340 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3W89_RS13350 ENOG4105DIJ Phosphoethanolamine transferase G3W89_RS13365 ENOG4107FQ9 ethanolamine ammonia-lyase G3W89_RS13370 ENOG4105CPD ethanolamine ammonia-lyase G3W89_RS13375 ENOG4108V1T peptidylprolyl cis-trans isomerase G3W89_RS13385 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G3W89_RS13395 ENOG4105CF1 Alkylated DNA repair protein G3W89_RS13470 ENOG4105C26 Dehydrogenase G3W89_RS13480 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS13485 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W89_RS13490 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W89_RS13535 ENOG41061ZR Transcriptional regulator G3W89_RS13545 ENOG4107RZC phospholipase d G3W89_RS13550 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G3W89_RS13555 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G3W89_RS13565 ENOG4105BZ1 (ABC) transporter G3W89_RS13570 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G3W89_RS13595 ENOG4105C0B DNA polymerase III (alpha subunit) G3W89_RS13615 ENOG4108W9H Tetr family transcriptional regulator G3W89_RS13620 ENOG4105C42 Type I secretion membrane fusion protein (HlyD G3W89_RS13625 ENOG4108JJA ABC, transporter G3W89_RS13665 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3W89_RS13670 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) G3W89_RS13685 ENOG4105NXH GreA GreB family elongation factor G3W89_RS13700 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W89_RS13705 ENOG4108ERU trap dicarboxylate transporter subunit DctP G3W89_RS13720 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS13725 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G3W89_RS13740 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G3W89_RS13745 ENOG4105CMV Succinyl-CoA synthetase subunit beta G3W89_RS13750 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS13770 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G3W89_RS13775 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS13820 ENOG4105CHR reductase G3W89_RS13850 ENOG4105D82 Glutamate dehydrogenase G3W89_RS13855 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G3W89_RS13865 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W89_RS13870 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) G3W89_RS13900 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G3W89_RS13905 ENOG4107HP6 Transcriptional regulator G3W89_RS13915 ENOG4105C7K acetolactate synthase G3W89_RS13920 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) G3W89_RS13940 ENOG4105MSY salicylate hydroxylase G3W89_RS13960 ENOG4108Z9W Outer membrane porin G3W89_RS13975 ENOG4105CSH Transporter G3W89_RS13995 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS14000 ENOG4106YT9 Enoyl-CoA hydratase G3W89_RS14005 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS14010 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS14015 ENOG4108X0B nad(p)h dehydrogenase (quinone) G3W89_RS14020 ENOG4105MP9 class II Aldolase G3W89_RS14025 ENOG4105CQZ Histidine kinase G3W89_RS14030 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G3W89_RS14040 ENOG4105CD5 CoA-binding domain protein G3W89_RS14045 ENOG4105CD5 CoA-binding domain protein G3W89_RS14050 ENOG4108IRC dna polymerase iii G3W89_RS14055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W89_RS14075 ENOG4107QN1 sodium solute G3W89_RS14080 ENOG41062QD Membrane G3W89_RS14100 ENOG4105D4P Coproporphyrinogen iii oxidase G3W89_RS14110 ENOG4105BZU Histidine kinase G3W89_RS14130 ENOG4105CRU nitrate reductase, alpha subunit G3W89_RS14135 ENOG4108IUE nitrate reductase beta subunit G3W89_RS14140 ENOG4105R3A Nitrate reductase G3W89_RS14145 ENOG4105D0D Nitrate reductase 2, gamma subunit G3W89_RS14150 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G3W89_RS14175 ENOG4105DZG Dehydrogenase G3W89_RS14180 ENOG4105VMH Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria (By similarity) G3W89_RS14190 ENOG4105DZG Dehydrogenase G3W89_RS14220 ENOG4105C26 Dehydrogenase G3W89_RS14250 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i G3W89_RS14285 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G3W89_RS14300 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G3W89_RS14310 ENOG41080TK Universal stress protein G3W89_RS14335 ENOG4105C0H protease G3W89_RS14345 ENOG4105F8V Hydrolase, tatD family G3W89_RS14355 ENOG4107QRG dna polymerase iii G3W89_RS14360 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G3W89_RS14365 ENOG4105HHA aminodeoxychorismate lyase G3W89_RS14370 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G3W89_RS14375 ENOG4105VCD cytoplasmic protein G3W89_RS14380 ENOG4105D22 carbon starvation protein G3W89_RS14410 ENOG4105C0A alcohol dehydrogenase G3W89_RS14415 ENOG4105ETT transcriptional Regulator, LysR family G3W89_RS14435 ENOG4105BZM domain protein G3W89_RS14440 ENOG4105EJC lysr family transcriptional regulator G3W89_RS14455 ENOG4105DJB Major Facilitator Superfamily G3W89_RS14465 ENOG4107QJQ Mate efflux family protein G3W89_RS14525 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3W89_RS14530 ENOG4105C2C drug resistance transporter, Bcr CflA G3W89_RS14545 ENOG4105DY2 Paraquat-inducible protein b G3W89_RS14550 ENOG4105F1S paraquat-inducible protein a G3W89_RS14555 ENOG4105H2K paraquat-inducible protein a G3W89_RS14560 ENOG4105HEI LysR family (Transcriptional regulator G3W89_RS14570 ENOG4105F27 Major Facilitator G3W89_RS14575 ENOG4105CPC Aldo Keto reductase G3W89_RS14580 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3W89_RS14585 ENOG4105DHQ Histidine kinase G3W89_RS14595 ENOG4105C2W permease G3W89_RS14600 ENOG4105KCV RNA signal recognition particle 4.5S RNA G3W89_RS14620 ENOG4105CSU acyl-Coa dehydrogenase G3W89_RS14625 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G3W89_RS14635 ENOG4105CHR reductase G3W89_RS14645 ENOG4105CSU acyl-Coa dehydrogenase G3W89_RS14655 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G3W89_RS14660 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W89_RS14665 ENOG4108IV0 ABC, transporter G3W89_RS14670 ENOG4105C0Z ABC transporter G3W89_RS14680 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS14690 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS14695 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G3W89_RS14700 ENOG4105CNG UPF0061 protein G3W89_RS14705 ENOG4105E0X reductase G3W89_RS14710 ENOG4107835 probably involved in intracellular septation (By similarity) G3W89_RS14720 ENOG4107TF3 peptidylprolyl cis-trans isomerase G3W89_RS14725 ENOG4108ETH Formylglycinamide ribotide synthetase G3W89_RS14730 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G3W89_RS14735 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G3W89_RS14740 ENOG4105MGM doxx family G3W89_RS14745 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G3W89_RS14755 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G3W89_RS14765 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G3W89_RS14825 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) G3W89_RS14830 ENOG4108IJ6 ABC transporter G3W89_RS14835 ENOG4105ECW sulfate abc transporter G3W89_RS14840 ENOG4108I5D sulfate abc transporter G3W89_RS14845 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G3W89_RS14855 ENOG4105JQN Transcriptional regulator G3W89_RS14860 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G3W89_RS14870 ENOG4105D7W serine acetyltransferase G3W89_RS14875 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G3W89_RS14880 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) G3W89_RS14885 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) G3W89_RS14900 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) G3W89_RS14910 ENOG4108UT2 hemolysin iii G3W89_RS14935 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) G3W89_RS14945 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) G3W89_RS14950 ENOG4108Z4U Ferredoxin G3W89_RS14955 ENOG4105CAY ferredoxin--nadp reductase G3W89_RS14960 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G3W89_RS14970 ENOG4105W2Z cytochrome C, class I G3W89_RS14980 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3W89_RS14985 ENOG4108TEB UPF0114 protein G3W89_RS15000 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G3W89_RS15035 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G3W89_RS15040 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G3W89_RS15045 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G3W89_RS15050 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G3W89_RS15065 ENOG4105ENT Efflux transporter rnd family, mfp subunit G3W89_RS15085 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W89_RS15120 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant G3W89_RS15125 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G3W89_RS15150 ENOG4108IV0 ABC, transporter G3W89_RS15155 ENOG4108IUZ ABC transporter G3W89_RS15165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W89_RS15225 ENOG4105CC0 LysR family Transcriptional regulator G3W89_RS15235 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS15245 ENOG4105CC9 acyl-Coa dehydrogenase G3W89_RS15255 ENOG4105CHR reductase G3W89_RS15285 ENOG4105EG6 Saccharopine dehydrogenase G3W89_RS15290 ENOG4105EAH synthase G3W89_RS15300 ENOG4105CVN desaturase G3W89_RS15305 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation G3W89_RS15310 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G3W89_RS15340 ENOG4105DHQ Histidine kinase G3W89_RS15345 ENOG4105VEJ Heat shock protein G3W89_RS15350 ENOG4105CSR polyphosphate kinase 2 G3W89_RS15440 ENOG4105DFP Integrase G3W89_RS15450 ENOG4105CFH Aspartokinase G3W89_RS15455 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G3W89_RS15460 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) G3W89_RS15470 ENOG4105C8N cysteinyl-tRNA synthetase G3W89_RS15490 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) G3W89_RS15495 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) G3W89_RS15510 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division G3W89_RS15515 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G3W89_RS15520 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) G3W89_RS15550 ENOG4106855 Competence protein G3W89_RS15555 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G3W89_RS15565 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G3W89_RS15570 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G3W89_RS15575 ENOG4107YIM Involved in the transcription termination process (By similarity) G3W89_RS15580 ENOG4105CHM Aminotransferase G3W89_RS15585 ENOG4107YD3 Thioesterase G3W89_RS15590 ENOG4105E02 MotA TolQ exbB proton channel G3W89_RS15595 ENOG4108ZZF transport protein (ExbD) G3W89_RS15615 ENOG4105C0B DNA polymerase III (alpha subunit) G3W89_RS15620 ENOG4105C72 UPF0176 protein G3W89_RS15625 ENOG4105EUB pirin domain protein G3W89_RS15635 ENOG4108VBZ doxx family G3W89_RS15655 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G3W89_RS15660 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G3W89_RS15685 ENOG4105CKT filamentous hemagglutinin G3W89_RS15690 ENOG4105D5K Hemolysin activator protein G3W89_RS15705 ENOG4105FDF Could be involved in DNA repair (By similarity) G3W89_RS15715 ENOG4105C8Q Methyl-accepting chemotaxis G3W89_RS15735 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G3W89_RS15740 ENOG4108Z6B deaminase G3W89_RS15765 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W89_RS15770 ENOG4105BZU Histidine kinase G3W89_RS15775 ENOG4105WH1 Two component transcriptional regulator luxr family G3W89_RS15790 ENOG4105CSH Transporter G3W89_RS15795 ENOG4105E2S oxidase) subunit II G3W89_RS15800 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3W89_RS15805 ENOG4105CCU oxidase (Subunit III) G3W89_RS15810 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) G3W89_RS15820 ENOG4105TX3 Histidine kinase G3W89_RS15825 ENOG4108UYB regulatoR G3W89_RS15830 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G3W89_RS15840 ENOG4105C4Y ABC transporter G3W89_RS15845 ENOG4107RCV ABC transporter, permease G3W89_RS15855 ENOG4107SM8 Adenylate Guanylate cyclase G3W89_RS15860 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G3W89_RS15865 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G3W89_RS15880 ENOG4108Z1B Cyclase dehydrase G3W89_RS15885 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G3W89_RS15920 ENOG4105CI3 gtp-binding protein typa G3W89_RS15925 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G3W89_RS15930 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) G3W89_RS15940 ENOG4105CHV Transcription elongation factor NusA G3W89_RS15945 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) G3W89_RS15950 ENOG4105CBP Major Facilitator G3W89_RS15955 ENOG4108JQ5 ABC transporter G3W89_RS15960 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component G3W89_RS15965 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component G3W89_RS15975 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G3W89_RS15995 ENOG4105CXN decarboxylase G3W89_RS16050 ENOG4105DQE DNA ligase G3W89_RS16150 ENOG4105DFP Integrase G3W89_RS16160 ENOG4105CP9 extracellular ligand-binding receptor G3W89_RS16175 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G3W89_RS16195 ENOG4107R11 Transcriptional regulator G3W89_RS16200 ENOG4105CHM Aminotransferase G3W89_RS16210 ENOG4105CQ7 ATP-dependent helicase G3W89_RS16215 ENOG4108EKC n-acetylglutamate synthase G3W89_RS16220 ENOG4105CHM Aminotransferase G3W89_RS16225 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) G3W89_RS16230 ENOG4105CZX twitching motility protein G3W89_RS16235 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G3W89_RS16240 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) G3W89_RS16245 ENOG4105C5H ABC transporter G3W89_RS16365 ENOG4105CUZ uba thif-type nad fad binding protein G3W89_RS16375 ENOG4105KCK Peptidoglycan-associated lipoprotein G3W89_RS16380 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) G3W89_RS16385 ENOG4105BZ1 (ABC) transporter G3W89_RS16390 ENOG4105C03 ribonuclease G3W89_RS16395 ENOG4108Z03 MAF-like protein G3W89_RS16400 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) G3W89_RS16405 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G3W89_RS16410 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G3W89_RS16415 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) G3W89_RS16420 ENOG4105C12 Phosphoribosylglycinamide synthetase G3W89_RS16425 ENOG4105CDY transcriptional regulatory protein G3W89_RS16470 ENOG4108M24 von Willebrand factor, type A G3W89_RS16485 ENOG4105C2D reductase G3W89_RS16520 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) G3W89_RS16535 ENOG4105D7A ATP-binding protein G3W89_RS16545 ENOG4105NCT RNA Polymerase G3W89_RS16555 ENOG4105E18 UPF0276 protein G3W89_RS16580 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G3W89_RS16585 ENOG4107TFB basic membrane G3W89_RS16590 ENOG4108JQ9 ABC transporter G3W89_RS16595 ENOG4105UIB (ABC) transporter G3W89_RS16605 ENOG4105DZC cytosine deaminase G3W89_RS16610 ENOG4105CJB Exodeoxyribonuclease I G3W89_RS16615 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G3W89_RS16620 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3W89_RS16625 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G3W89_RS16645 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G3W89_RS16650 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G3W89_RS16660 ENOG4108ZZF transport protein (ExbD) G3W89_RS16665 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) G3W89_RS16670 ENOG4105W49 UPF0434 protein G3W89_RS16675 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) G3W89_RS16680 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G3W89_RS16695 ENOG4105HDK L-asparaginase G3W89_RS16700 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G3W89_RS16710 ENOG4108JQ1 Dehydrogenase G3W89_RS16715 ENOG4105F27 Major Facilitator G3W89_RS16725 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W89_RS16730 ENOG4108UKI Enoyl-CoA hydratase G3W89_RS16755 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G3W89_RS16765 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W89_RS16770 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) G3W89_RS16775 ENOG4105HBR Rna-binding protein G3W89_RS16790 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G3W89_RS16800 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G3W89_RS16815 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G3W89_RS16820 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3W89_RS16825 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3W89_RS16830 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) G3W89_RS16835 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3W89_RS16845 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G3W89_RS16850 ENOG4105DZP Membrane-associated zinc metalloprotease G3W89_RS16855 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G3W89_RS16860 ENOG4105KNE Phosphatidate cytidylyltransferase G3W89_RS16865 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G3W89_RS16870 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G3W89_RS16875 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G3W89_RS16880 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) G3W89_RS16885 ENOG4105CE9 30S ribosomal protein S2 G3W89_RS16900 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G3W89_RS16905 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3W89_RS16910 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G3W89_RS16920 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) G3W89_RS16925 ENOG4108NVM synthesis repressor PhaR G3W89_RS16940 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3W89_RS16945 ENOG4105DTD Dehydrogenase G3W89_RS16965 ENOG4105E0F Histidine kinase G3W89_RS16970 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) G3W89_RS16975 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) G3W89_RS16980 ENOG4108JA2 transcriptioN-repair coupling factor G3W89_RS16985 ENOG4105EAC phosphoserine phosphatase G3W89_RS17010 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W89_RS17015 ENOG4105CSM endonuclease III G3W89_RS17020 ENOG4105DS1 cytochrome b561 G3W89_RS17030 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) G3W89_RS17035 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G3W89_RS17040 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G3W89_RS17055 ENOG4105C1P efflux transporter, rnd family, mfp subunit G3W89_RS17080 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G3W89_RS17085 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G3W89_RS17090 ENOG4105S6R Iron-hydroxamate transporter permease subunit G3W89_RS17095 ENOG4108HUF Transporter G3W89_RS17100 ENOG4108YZT Adenosylcobinamide kinase G3W89_RS17105 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G3W89_RS17120 ENOG4105HF0 Membrane G3W89_RS17130 ENOG4105ECQ AraC Family Transcriptional Regulator G3W89_RS17135 ENOG4105ES4 Nitrilase G3W89_RS17140 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS17160 ENOG4105DRR Transcriptional regulator, GntR family G3W89_RS17165 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) G3W89_RS17170 ENOG4106NZI LysR family Transcriptional regulator G3W89_RS17175 ENOG4105C01 Dihydroxy-acid dehydratase G3W89_RS17200 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) G3W89_RS17205 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G3W89_RS17215 ENOG4105VUH addiction module killer protein G3W89_RS17220 ENOG4105YES addiction module antidote protein G3W89_RS17235 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G3W89_RS17245 ENOG4105DQE DNA ligase G3W89_RS17290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3W89_RS17295 ENOG4105DEI Mannitol dehydrogenase G3W89_RS17300 ENOG4105CHR reductase G3W89_RS17305 ENOG4105EQD regulatoR G3W89_RS17310 ENOG4105CMG Carbohydrate kinase G3W89_RS17325 ENOG4105C0H protease G3W89_RS17330 ENOG4105DHQ Histidine kinase G3W89_RS17335 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3W89_RS17340 ENOG4107HP6 Transcriptional regulator G3W89_RS17345 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase G3W89_RS17355 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) G3W89_RS17360 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate G3W89_RS17365 ENOG41069M3 Transcriptional regulator G3W89_RS17370 ENOG41061WM D-Alanyl-D-Alanine G3W89_RS17375 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G3W89_RS17380 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G3W89_RS17385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G3W89_RS17390 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G3W89_RS17395 ENOG4108ZP8 Acetolactate synthase small subunit G3W89_RS17400 ENOG4105C7K acetolactate synthase G3W89_RS17425 ENOG41080IJ Diacylglycerol kinase G3W89_RS17430 ENOG4108URH decarboxylase G3W89_RS17435 ENOG4108YZA Nitrogen regulatory protein pii G3W89_RS17440 ENOG4105FDR Membrane G3W89_RS17450 ENOG4105F0N pyrophosphate phospho-hydrolase G3W89_RS17475 ENOG4107RZC phospholipase d G3W89_RS17485 ENOG4105C26 Dehydrogenase G3W89_RS17500 ENOG41080TK Universal stress protein G3W89_RS17505 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class G3W89_RS17515 ENOG4105CHR reductase G3W89_RS17540 ENOG4105CF7 AraC family transcriptional regulator G3W89_RS17545 ENOG4105CHR reductase G3W89_RS17555 ENOG4105DBV ornithine carbamoyltransferase G3W89_RS17580 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3W89_RS17600 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) G3W89_RS17605 ENOG4105CY0 Metallo-Beta-Lactamase G3W89_RS17635 ENOG41080TK Universal stress protein G3W89_RS17640 ENOG4107Y70 Heat shock protein G3W89_RS17680 ENOG4105C0H protease G3W89_RS17705 ENOG4105ERH Fumarylacetoacetate hydrolase G3W89_RS17710 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase G3W89_RS17715 ENOG4107XBN GntR Family Transcriptional Regulator G3W89_RS17720 ENOG4108YYH Nadph-dependent fmn reductase G3W89_RS17725 ENOG4105CV1 Transketolase (EC 2.2.1.1) G3W89_RS17730 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) G3W89_RS17735 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 G3W89_RS17750 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 G3W89_RS17755 ENOG4106F1P AAA ATPase, central domain protein G3W89_RS17760 ENOG4108VFZ ribulose bisphosphate carboxylase, small G3W89_RS17765 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate G3W89_RS17770 ENOG4105DUM transcriptional regulator, lysR family G3W89_RS17780 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS17800 ENOG4105CJ1 ABC, transporter G3W89_RS17805 ENOG4105DZG Dehydrogenase G3W89_RS17810 ENOG4105WJN methanol dehydrogenase-like protein, cytochrome cL (XoxG) G3W89_RS17830 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G3W89_RS17860 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E G3W89_RS17865 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d G3W89_RS17870 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) G3W89_RS17875 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) G3W89_RS17890 ENOG4105BZU Histidine kinase G3W89_RS17895 ENOG4105WH1 Two component transcriptional regulator luxr family G3W89_RS17925 ENOG4105FIE Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) (By similarity) G3W89_RS17930 ENOG4105DCC Formylmethanofuran dehydrogenase subunit A G3W89_RS17940 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G3W89_RS17980 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family G3W89_RS17990 ENOG4108P4C Formaldehyde-activating enzyme G3W89_RS18000 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) G3W89_RS18005 ENOG41068T5 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT (By similarity) G3W89_RS18015 ENOG4108M6X Dehydrogenase G3W89_RS18030 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G3W89_RS18035 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G3W89_RS18040 ENOG4105CVM Molybdenum cofactor synthesis domain protein G3W89_RS18050 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G3W89_RS18060 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G3W89_RS18065 ENOG4105E9H Lytic Murein transglycosylase G3W89_RS18070 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3W89_RS18080 ENOG4105D2X ABC transporter substrate-binding protein G3W89_RS18090 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G3W89_RS18095 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G3W89_RS18100 ENOG4107QMP dna polymerase iii subunits gamma and tau G3W89_RS18125 ENOG4105CAU Arsenical resistance protein, ArsH G3W89_RS18130 ENOG4105D6J arsenicaL-resistance protein G3W89_RS18135 ENOG41085FC arsR family transcriptional regulator G3W89_RS18150 ENOG41080HT Transcriptional regulator, arsr family G3W89_RS18180 ENOG4107TPS domain protein G3W89_RS18205 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3W89_RS18210 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation G3W89_RS18220 ENOG4105K63 Thioredoxin G3W89_RS18225 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G3W89_RS18230 ENOG4105D9R oxidoreductase G3W89_RS18235 ENOG4105NRA 50s ribosomal protein l31 type b G3W89_RS18245 ENOG4107QI1 Mate efflux family protein G3W89_RS18250 ENOG4105BZU Histidine kinase G3W89_RS18255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W89_RS18265 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G3W89_RS18270 ENOG4105E2Z phosphate ABC transporter (Permease G3W89_RS18275 ENOG4105C8U phosphate abc transporter G3W89_RS18280 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G3W89_RS18285 ENOG4105C9X ppx gppa phosphatase G3W89_RS18295 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G3W89_RS18305 ENOG4108JU3 Alkyl hydroperoxide reductase G3W89_RS18310 ENOG4105CYM Glutathione S-transferase G3W89_RS18365 ENOG4105CD5 CoA-binding domain protein G3W89_RS18375 ENOG4105CGU Enoyl-CoA hydratase G3W89_RS18380 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS18385 ENOG4105CC9 acyl-Coa dehydrogenase G3W89_RS18415 ENOG4105CGU Enoyl-CoA hydratase G3W89_RS18420 ENOG41073TP transcriptional regulator G3W89_RS18425 ENOG4107U2T alpha beta G3W89_RS18430 ENOG4105CPC Aldo Keto reductase G3W89_RS18440 ENOG4105X7H acyl-CoA dehydrogenase G3W89_RS18455 ENOG4107S2E monooxygenase G3W89_RS18465 ENOG4105CHR reductase G3W89_RS18495 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G3W89_RS18505 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) G3W89_RS18515 ENOG4105E2X shikimate dehydrogenase G3W89_RS18535 ENOG4107S2E monooxygenase G3W89_RS18540 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G3W89_RS18550 ENOG4107EFR Flavocytochrome c G3W89_RS18605 ENOG4105CHR reductase G3W89_RS18615 ENOG4105CHR reductase G3W89_RS18620 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS18625 ENOG4105CHR reductase G3W89_RS18635 ENOG4108IV0 ABC, transporter G3W89_RS18640 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS18645 ENOG4105C6F GntR Family Transcriptional Regulator G3W89_RS18680 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS18705 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS18720 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS18735 ENOG4108UW8 fha domain-containing protein G3W89_RS18740 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G3W89_RS18745 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W89_RS18775 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3W89_RS18795 ENOG4105E3J oxidoreductase G3W89_RS18835 ENOG4105C7F AcnD-accessory protein PrpF G3W89_RS18845 ENOG4105F04 LysR family Transcriptional regulator G3W89_RS18850 ENOG4105CK2 sodium dicarboxylate symporter G3W89_RS18855 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G3W89_RS18870 ENOG4108M9J MaoC like domain protein G3W89_RS18880 ENOG4105D8G Major Facilitator superfamily G3W89_RS18895 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3W89_RS18900 ENOG4108IPJ Membrane G3W89_RS18905 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3W89_RS18915 ENOG4108IV0 ABC, transporter G3W89_RS18920 ENOG4105C0Z ABC transporter G3W89_RS18935 ENOG4105CHR reductase G3W89_RS18940 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G3W89_RS18950 ENOG41066T0 asmA family G3W89_RS18975 ENOG41060WC Enoyl-CoA hydratase G3W89_RS18985 ENOG4105K6S Short-chain dehydrogenase reductase Sdr G3W89_RS19005 ENOG4107YZX Universal stress protein G3W89_RS19015 ENOG4105CCT upf0313 protein G3W89_RS19020 ENOG410645S MarR family Transcriptional regulator G3W89_RS19045 ENOG4107S2Z UPF0761 membrane protein G3W89_RS19060 ENOG4105CPC Aldo Keto reductase G3W89_RS19085 ENOG4105C2N RNA methyltransferase TrmH family group 3 G3W89_RS19090 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3W89_RS19095 ENOG4108UJV acyl-CoA thioesterase i G3W89_RS19105 ENOG4105C28 cystathionine G3W89_RS19115 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G3W89_RS19120 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) G3W89_RS19130 ENOG4105EPW hflc protein G3W89_RS19135 ENOG4107QJR hflk protein G3W89_RS19140 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G3W89_RS19145 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) G3W89_RS19150 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G3W89_RS19155 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G3W89_RS19165 ENOG4105CUT histidyl-tRNA synthetase G3W89_RS19170 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G3W89_RS19185 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G3W89_RS19190 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G3W89_RS19195 ENOG4105FE9 pseudouridine synthase G3W89_RS19200 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G3W89_RS19205 ENOG4105C34 Pseudouridine synthase G3W89_RS19210 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G3W89_RS19215 ENOG4105DVT helicase G3W89_RS19235 ENOG4105D6Z AFG1 family ATPase G3W89_RS19240 ENOG4107QN2 dihydrolipoyl dehydrogenase G3W89_RS19245 ENOG4105C7S Dehydrogenase G3W89_RS19250 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G3W89_RS19255 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3W89_RS19265 ENOG4108JUA Transcriptional regulator G3W89_RS19275 ENOG41082A2 Alpha beta hydrolase G3W89_RS19285 ENOG4105ER2 Ompa motb domain protein G3W89_RS19305 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3W89_RS19310 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G3W89_RS19320 ENOG4105D8V Glucose sorbosone dehydrogenase G3W89_RS19325 ENOG4105K4H Nlp p60 protein G3W89_RS19330 ENOG4107QN2 dihydrolipoyl dehydrogenase G3W89_RS19335 ENOG4107QSN dihydrolipoamide acetyltransferase G3W89_RS19340 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G3W89_RS19345 ENOG4105BZU Histidine kinase G3W89_RS19350 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W89_RS19355 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G3W89_RS19360 ENOG4105DGW oligopeptidase A G3W89_RS19370 ENOG4105E66 phosphoriboisomerase A G3W89_RS19375 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G3W89_RS19390 ENOG4105D5U fad dependent oxidoreductase G3W89_RS19405 ENOG4107RZZ dna polymerase iii epsilon subunit G3W89_RS19410 ENOG4108ZIT Ferredoxin, 2FE-2S G3W89_RS19415 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB G3W89_RS19420 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) G3W89_RS19430 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins G3W89_RS19435 ENOG4105C3J Cysteine desulfurase G3W89_RS19440 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family G3W89_RS19450 ENOG4105CGF Aromatic amino acid aminotransferase G3W89_RS19460 ENOG4108R3D Electron transport complex G3W89_RS19480 ENOG4107QX3 carboxylase G3W89_RS19485 ENOG4105DJT lAO AO transport system ATPase G3W89_RS19495 ENOG4105DRR Transcriptional regulator, GntR family G3W89_RS19515 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G3W89_RS19520 ENOG4107QRT dEAD DEAH box helicase G3W89_RS19525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W89_RS19560 ENOG4105CKD glutathione-regulated potassium-efflux system protein G3W89_RS19565 ENOG4105CK2 sodium dicarboxylate symporter G3W89_RS19570 ENOG4105CHR reductase G3W89_RS19590 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS19595 ENOG4105EGI Transcriptional regulator G3W89_RS19600 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS19605 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class G3W89_RS19615 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G3W89_RS19635 ENOG4108RH0 Crea protein G3W89_RS19640 ENOG4108K5P (LipO)protein G3W89_RS19645 ENOG4107RZC phospholipase d G3W89_RS19660 ENOG4105F04 LysR family Transcriptional regulator G3W89_RS19665 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3W89_RS19695 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS19705 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS19730 ENOG4107W7X Aldolase G3W89_RS19735 ENOG4105FP9 thiamine pyrophosphate G3W89_RS19740 ENOG4105C26 Dehydrogenase G3W89_RS19760 ENOG4108UKV benzoate 1,2-dioxygenase G3W89_RS19795 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS19805 ENOG4105DND Transcriptional regulator G3W89_RS19835 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W89_RS19840 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G3W89_RS19875 ENOG4105DVF Cytosine-specific methyltransferase G3W89_RS19945 ENOG4106NZI LysR family Transcriptional regulator G3W89_RS19960 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W89_RS19965 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W89_RS19980 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS19995 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS20040 ENOG4105C0A alcohol dehydrogenase G3W89_RS20050 ENOG4108Z9W Outer membrane porin G3W89_RS20060 ENOG4105MP9 class II Aldolase G3W89_RS20065 ENOG4108FUF Transcriptional regulator, IclR family G3W89_RS20090 ENOG4108T2C cysteine dioxygenase type I G3W89_RS20105 ENOG4105HMI Membrane G3W89_RS20120 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS20125 ENOG4105FDP GntR family transcriptional regulator G3W89_RS20130 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS20145 ENOG4105D5G Transposase G3W89_RS20155 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS20175 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS20185 ENOG4105C7F AcnD-accessory protein PrpF G3W89_RS20190 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS20210 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS20255 ENOG4107QJE Chromosome Partitioning Protein G3W89_RS20310 ENOG4105FA0 parb-like partition protein G3W89_RS20325 ENOG4105W5Q DNA repair protein (RadC G3W89_RS20355 ENOG4105DFP Integrase G3W89_RS20370 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G3W89_RS20375 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G3W89_RS20380 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G3W89_RS20385 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G3W89_RS20390 ENOG4105VJV 50s ribosomal protein L35 G3W89_RS20395 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G3W89_RS20400 ENOG4105C22 threonyL-tRNA synthetase G3W89_RS20405 ENOG4108I9X Isocitrate lyase G3W89_RS20430 ENOG4108W9H Tetr family transcriptional regulator G3W89_RS20465 ENOG4107S8A protein TIM barrel G3W89_RS20480 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G3W89_RS20505 ENOG4105CHH sulfate transporter G3W89_RS20510 ENOG4108YZN class I peptide chain release factor G3W89_RS20525 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3W89_RS20545 ENOG4106NZI LysR family Transcriptional regulator G3W89_RS20555 ENOG4108ZAF Molybdopterin G3W89_RS20560 ENOG4105M00 molybdopterin converting factor, subunit 1 G3W89_RS20565 ENOG4105CVM Molybdenum cofactor synthesis domain protein G3W89_RS20570 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b G3W89_RS20575 ENOG4105D98 threonine synthase G3W89_RS20580 ENOG4105D6E homoserine dehydrogenase G3W89_RS20585 ENOG4105CHM Aminotransferase G3W89_RS20595 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G3W89_RS20600 ENOG4108IAB Phoh family G3W89_RS20615 ENOG4105CDU Replicative dna helicase G3W89_RS20620 ENOG4105K9Q Binds to the 23S rRNA (By similarity) G3W89_RS20625 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G3W89_RS20635 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) G3W89_RS20650 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) G3W89_RS20655 ENOG4108JU3 Alkyl hydroperoxide reductase G3W89_RS20660 ENOG4105D3R alkyl hydroperoxide reductase G3W89_RS20675 ENOG4105HB4 Pathways of utilization of iron bound to transferrin, lactoferrin and hemoglobin but not to haemin or citrate where dependent on the TonB system G3W89_RS20685 ENOG4105M8F Biopolymer transport protein exbD tolR G3W89_RS20695 ENOG4108ZJF Glcg protein G3W89_RS20700 ENOG4108MN8 Membrane G3W89_RS20705 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G3W89_RS20710 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W89_RS20715 ENOG4108K5P (LipO)protein G3W89_RS20720 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G3W89_RS20725 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) G3W89_RS20745 ENOG4107TF3 peptidylprolyl cis-trans isomerase G3W89_RS20760 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3W89_RS20765 ENOG4105EBM Alpha Beta Hydrolase Fold protein G3W89_RS20770 ENOG4105EJC lysr family transcriptional regulator G3W89_RS20790 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G3W89_RS20800 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G3W89_RS20820 ENOG4105C5I Dehydrogenase G3W89_RS20830 ENOG4107RH7 Nicotinate phosphoribosyltransferase G3W89_RS20835 ENOG4105VDW Csbd family G3W89_RS20850 ENOG4105DGU Histone deacetylase G3W89_RS20855 ENOG4108WFY phasin family G3W89_RS20865 ENOG4107S2Z UPF0761 membrane protein G3W89_RS20870 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G3W89_RS20875 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W89_RS20880 ENOG4105C2C drug resistance transporter, Bcr CflA G3W89_RS20895 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS20900 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W89_RS20920 ENOG4108IV0 ABC, transporter G3W89_RS20925 ENOG4105C0Z ABC transporter G3W89_RS20950 ENOG4108WYP Transcriptional regulator G3W89_RS20970 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G3W89_RS20985 ENOG4105E90 ABC transporter G3W89_RS20990 ENOG4105C26 Dehydrogenase G3W89_RS20995 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase G3W89_RS21005 ENOG4107YCY Transcriptional regulator G3W89_RS21010 ENOG4105E9Z Nad-dependent epimerase dehydratase G3W89_RS21015 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W89_RS21025 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS21030 ENOG4105CTX dehydratase G3W89_RS21040 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G3W89_RS21050 ENOG4105DJ4 phosphatidylserine decarboxylase G3W89_RS21060 ENOG4108V1T peptidylprolyl cis-trans isomerase G3W89_RS21065 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G3W89_RS21070 ENOG4105CFG Acts as a chaperone (By similarity) G3W89_RS21075 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G3W89_RS21080 ENOG4105ERH Fumarylacetoacetate hydrolase G3W89_RS21090 ENOG4105CYN Serine protein kinase G3W89_RS21095 ENOG4106AKX UPF0229 protein G3W89_RS21100 ENOG4105ED1 spovr family G3W89_RS21105 ENOG4108R3E Dna-3-methyladenine glycosylase i G3W89_RS21110 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G3W89_RS21115 ENOG4107QPD alcohol dehydrogenase G3W89_RS21120 ENOG4105C4W S-formylglutathione hydrolase G3W89_RS21125 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G3W89_RS21140 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3W89_RS21150 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3W89_RS21160 ENOG4107RZC phospholipase d G3W89_RS21170 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G3W89_RS21175 ENOG4107S9R deoxycytidine triphosphate deaminase G3W89_RS21180 ENOG4107S9R deoxycytidine triphosphate deaminase G3W89_RS21215 ENOG4105D4U had-superfamily hydrolase, subfamily iia G3W89_RS21220 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G3W89_RS21245 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G3W89_RS21255 ENOG4107S2Z UPF0761 membrane protein G3W89_RS21265 ENOG4105CQB FAD linked oxidase domain protein G3W89_RS21270 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) G3W89_RS21275 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) G3W89_RS21305 ENOG4105CGK Exodeoxyribonuclease III G3W89_RS21315 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W89_RS21320 ENOG4105CUX Signal transduction histidine kinase G3W89_RS21335 ENOG4105CEV competence damage-inducible protein G3W89_RS21360 ENOG4105I08 Pseudouridine synthase G3W89_RS21370 ENOG4106R49 Methyltransferase G3W89_RS21385 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G3W89_RS21390 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G3W89_RS21395 ENOG4105UYK outer membrane protein a G3W89_RS21400 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W89_RS21410 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G3W89_RS21415 ENOG4105CQC Prephenate dehydratase G3W89_RS21425 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G3W89_RS21430 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G3W89_RS21445 ENOG4105CFV Tetratricopeptide repeat protein G3W89_RS21465 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS21470 ENOG4107Z6W Protein CrcB homolog G3W89_RS21475 ENOG4105D65 subunit l G3W89_RS21480 ENOG4108ZE9 Monovalent cation H antiporter subunit C G3W89_RS21485 ENOG4107R4Z monovalent cation h antiporter subunit d G3W89_RS21495 ENOG4105W4C monovalent cation H antiporter subunit F G3W89_RS21500 ENOG4105KJM monovalent cation h antiporter subunit g G3W89_RS21555 ENOG4107T8Q Glycosyl transferase (Group 1 G3W89_RS21575 ENOG4108YYC ycei family G3W89_RS21595 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family G3W89_RS21610 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G3W89_RS21640 ENOG4108IJ0 Aspartate ammonia-lyase G3W89_RS21645 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3W89_RS21655 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G3W89_RS21660 ENOG4105E0C molybdate abc transporter G3W89_RS21665 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G3W89_RS21680 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G3W89_RS21685 ENOG4105F0N pyrophosphate phospho-hydrolase G3W89_RS21690 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W89_RS21710 ENOG4108JJB ABC transporter G3W89_RS21720 ENOG4105F4R Transcriptional regulator mode G3W89_RS21740 ENOG4108IV0 ABC, transporter G3W89_RS21745 ENOG4105C0Z ABC transporter G3W89_RS21765 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G3W89_RS21770 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit G3W89_RS21775 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit G3W89_RS21780 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit G3W89_RS21785 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit G3W89_RS21795 ENOG4108ZJI phenylacetic acid degradation protein G3W89_RS21800 ENOG4108UKI Enoyl-CoA hydratase G3W89_RS21805 ENOG4108Z0R Transferase G3W89_RS21810 ENOG4108IG5 Transcriptional regulator G3W89_RS21815 ENOG4105E6M Sulphatase-modifying factor protein G3W89_RS21825 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS21855 ENOG4108JJ6 Type I secretion system ATPase G3W89_RS21860 ENOG4105CH5 extracellular solute-binding protein, family 7 G3W89_RS21865 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) G3W89_RS21875 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G3W89_RS21890 ENOG4105KHC sulfurtransferase G3W89_RS21905 ENOG4105D60 lipoprotein releasing system transmembrane protein G3W89_RS21915 ENOG4105WKW Pfam:DUF1458 G3W89_RS21940 ENOG4107RP9 extracellular solute-binding protein, family 3 G3W89_RS21945 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W89_RS21960 ENOG4105C2M dna polymerase I G3W89_RS21970 ENOG4105CUV Homoserine Kinase G3W89_RS21980 ENOG4105C4R Atp-dependent dna helicase G3W89_RS21985 ENOG4108QVN serine threonine protein kinase G3W89_RS21990 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) G3W89_RS22005 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS22020 ENOG4105C1J atp-dependent rna helicase G3W89_RS22025 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) G3W89_RS22030 ENOG4105D0M Protease HtpX homolog G3W89_RS22035 ENOG41090A4 Pterin carbinolamine dehydratase G3W89_RS22040 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G3W89_RS22045 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G3W89_RS22050 ENOG4105CIH Imidazole acetol-phosphate transaminase G3W89_RS22055 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) G3W89_RS22060 ENOG4105P8F nudix hydrolase G3W89_RS22065 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G3W89_RS22070 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) G3W89_RS22075 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G3W89_RS22080 ENOG4105K5M 30s ribosomal protein S16 G3W89_RS22095 ENOG4107QXV Phosphate transporter G3W89_RS22100 ENOG4107GRR phosphate transport regulator G3W89_RS22105 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G3W89_RS22110 ENOG4105DJ0 Poly(A) Polymerase G3W89_RS22115 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) G3W89_RS22120 ENOG4105CXB phosphoribosylaminoimidazole synthetase G3W89_RS22125 ENOG4106F5Q Membrane G3W89_RS22135 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G3W89_RS22155 ENOG4105CJR Integral membrane protein (MviN G3W89_RS22160 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) G3W89_RS22170 ENOG4105C8Y Acetylornithine aminotransferase G3W89_RS22175 ENOG4105DBV ornithine carbamoyltransferase G3W89_RS22180 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) G3W89_RS22190 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) G3W89_RS22235 ENOG4105MSY salicylate hydroxylase G3W89_RS22245 ENOG4105CE1 Ferrous iron transport protein b G3W89_RS22255 ENOG4107QM5 aconitate hydratase G3W89_RS22270 ENOG4107QIJ Aconitate hydratase 2 G3W89_RS22280 ENOG4105CI0 Citrate lyase G3W89_RS22285 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) G3W89_RS22290 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G3W89_RS22295 ENOG4105FDP GntR family transcriptional regulator G3W89_RS22310 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G3W89_RS22315 ENOG4105E33 succinate dehydrogenase G3W89_RS22320 ENOG41060IS Flavinator of succinate dehydrogenase G3W89_RS22325 ENOG4105BZN citrate synthase G3W89_RS22340 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W89_RS22345 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W89_RS22350 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3W89_RS22355 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G3W89_RS22365 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) G3W89_RS22370 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase G3W89_RS22375 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G3W89_RS22380 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G3W89_RS22385 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) G3W89_RS22390 ENOG4108VIA integral membrane protein G3W89_RS22400 ENOG4105CRK lysyL-tRNA synthetase G3W89_RS22405 ENOG4105R8A Heat shock protein G3W89_RS22410 ENOG4108VKG metal-dependent hydrolase G3W89_RS22420 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) G3W89_RS22425 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) G3W89_RS22430 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) G3W89_RS22435 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G3W89_RS22440 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G3W89_RS22450 ENOG4105C3F Signal peptidase i G3W89_RS22455 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G3W89_RS22460 ENOG4105C0H protease G3W89_RS22475 ENOG4105EMN RNA polymerase sigma factor G3W89_RS22485 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G3W89_RS22490 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G3W89_RS22495 ENOG4105CHR reductase G3W89_RS22500 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G3W89_RS22505 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G3W89_RS22510 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) G3W89_RS22515 ENOG4105VGS 50s ribosomal protein l32 G3W89_RS22520 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein G3W89_RS22525 ENOG4108UHJ MAF-like protein G3W89_RS22530 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G3W89_RS22535 ENOG4106UW1 Major Facilitator superfamily G3W89_RS22540 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G3W89_RS22555 ENOG4105EI2 Pseudouridine synthase G3W89_RS22560 ENOG4105C03 ribonuclease G3W89_RS22565 ENOG4105D3Q Sugar transferase G3W89_RS22575 ENOG4105C30 Nad-dependent epimerase dehydratase G3W89_RS22595 ENOG4106CD9 glycosyl transferase group 1 G3W89_RS22630 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G3W89_RS22635 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) G3W89_RS22640 ENOG410642W LysR family Transcriptional regulator G3W89_RS22645 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G3W89_RS22695 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) G3W89_RS22710 ENOG4105D1Q UPF0246 protein G3W89_RS22720 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G3W89_RS22730 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) G3W89_RS22735 ENOG4105E09 nadh pyrophosphatase G3W89_RS22740 ENOG4105C6T cysteine synthase G3W89_RS22750 ENOG4105VFU Rna-binding protein G3W89_RS22765 ENOG4105WH1 Two component transcriptional regulator luxr family G3W89_RS22770 ENOG4105C0H protease G3W89_RS22780 ENOG4108YYQ gCN5-related N-acetyltransferase G3W89_RS22800 ENOG4108IV0 ABC, transporter G3W89_RS22805 ENOG4105C0Z ABC transporter G3W89_RS22810 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G3W89_RS22815 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS22820 ENOG4105D1H recombination factor protein RarA G3W89_RS22825 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) G3W89_RS22830 ENOG4105CNU cell division protein FtsK G3W89_RS22840 ENOG4105C3M thioredoxin reductase G3W89_RS22845 ENOG4105KDC 50s ribosomal protein l28 G3W89_RS22850 ENOG4105W0E 50S ribosomal protein L33 G3W89_RS22865 ENOG4108V3E phosphoribosylglycinamide formyltransferase G3W89_RS22870 ENOG4105X7H acyl-CoA dehydrogenase G3W89_RS22875 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS22885 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS22895 ENOG4105DTN riboflavin biosynthesis protein ribF G3W89_RS22905 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G3W89_RS22910 ENOG4105EAM Na Pi-cotransporter G3W89_RS22915 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3W89_RS22920 ENOG4105CHR reductase G3W89_RS22930 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G3W89_RS22950 ENOG4107QHF type ii secretion system protein e G3W89_RS22955 ENOG4105I7M spermidine synthase G3W89_RS22970 ENOG4105EYA deoxyribonuclease G3W89_RS22975 ENOG4105C0H protease G3W89_RS22980 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G3W89_RS23000 ENOG4105RQF LysR family Transcriptional regulator G3W89_RS23010 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G3W89_RS23035 ENOG4105CAF HipA N-terminal domain protein G3W89_RS23045 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3W89_RS23060 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G3W89_RS23080 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G3W89_RS23085 ENOG4105BZU Histidine kinase G3W89_RS23090 ENOG4108YZ9 Urea amidohydrolase subunit gamma G3W89_RS23100 ENOG4105KI2 Urea amidohydrolase subunit beta G3W89_RS23105 ENOG4105CQM Urea amidohydrolase subunit alpha G3W89_RS23110 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) G3W89_RS23115 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G3W89_RS23120 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) G3W89_RS23130 ENOG4105C7K acetolactate synthase G3W89_RS23160 ENOG4105CSA Coproporphyrinogen iii oxidase G3W89_RS23165 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G3W89_RS23170 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G3W89_RS23180 ENOG4105D9P serine threonine protein kinase G3W89_RS23185 ENOG4105DSJ YicC domain protein G3W89_RS23190 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G3W89_RS23195 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) G3W89_RS23200 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3W89_RS23205 ENOG4108RRZ Transcription elongation factor GreB G3W89_RS23220 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G3W89_RS23225 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G3W89_RS23230 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G3W89_RS23235 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G3W89_RS23240 ENOG4105CEN a g-specific adenine glycosylase G3W89_RS23245 ENOG410890F Dynamin family G3W89_RS23250 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G3W89_RS23265 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G3W89_RS23275 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G3W89_RS23280 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G3W89_RS23285 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G3W89_RS23295 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G3W89_RS23305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W89_RS23315 ENOG4108JQ7 (ABC) transporter G3W89_RS23320 ENOG4105DEF Extracellular solute-binding protein, family 5 G3W89_RS23325 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W89_RS23330 ENOG4107NQ8 LysR family Transcriptional regulator G3W89_RS23360 ENOG4105CVJ phosphoglycerate mutase G3W89_RS23365 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G3W89_RS23370 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G3W89_RS23375 ENOG4107QSN dihydrolipoamide acetyltransferase G3W89_RS23380 ENOG4107QN2 dihydrolipoyl dehydrogenase G3W89_RS23385 ENOG4105EV9 Alpha Beta Hydrolase G3W89_RS23390 ENOG4105C6K Malic enzyme G3W89_RS23400 ENOG4105CEP NADH dehydrogenase G3W89_RS23405 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class G3W89_RS23410 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS23415 ENOG4105CHR reductase G3W89_RS23425 ENOG4105C4M (Ubiquinol oxidase) subunit I G3W89_RS23430 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G3W89_RS23435 ENOG4105CQZ Histidine kinase G3W89_RS23440 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W89_RS23445 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) G3W89_RS23450 ENOG4105E7W lamb ycsf family protein G3W89_RS23455 ENOG4107R7A Allophanate hydrolase subunit 2 G3W89_RS23460 ENOG4105P4J Allophanate hydrolase, subunit 1 G3W89_RS23465 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G3W89_RS23470 ENOG4106H78 methyltransferase G3W89_RS23495 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W89_RS23505 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G3W89_RS23530 ENOG4107QS1 Cytochrome C Oxidase, Subunit III G3W89_RS23540 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) G3W89_RS23545 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3W89_RS23560 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G3W89_RS23570 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G3W89_RS23585 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G3W89_RS23600 ENOG4105E9F Enoyl-CoA hydratase G3W89_RS23620 ENOG4105CSU acyl-Coa dehydrogenase G3W89_RS23640 ENOG4105CIF Ornithine Cyclodeaminase G3W89_RS23645 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS23650 ENOG4107QNJ CoA-transferase subunit B G3W89_RS23660 ENOG4107HP6 Transcriptional regulator G3W89_RS23675 ENOG4105K70 DNA-binding protein G3W89_RS23680 ENOG4105DIA mandelate racemase muconate lactonizing G3W89_RS23685 ENOG4105CG3 alpha amylase, catalytic region G3W89_RS23690 ENOG4105CG3 alpha amylase, catalytic region G3W89_RS23695 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G3W89_RS23700 ENOG4108PZW LysR family Transcriptional regulator G3W89_RS23710 ENOG4108ERU trap dicarboxylate transporter subunit DctP G3W89_RS23730 ENOG4105ZXK Dehydrogenase G3W89_RS23745 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3W89_RS23755 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) G3W89_RS23765 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W89_RS23770 ENOG4106P55 Transcriptional regulator G3W89_RS23785 ENOG4105ESI atpase involved in dna repair G3W89_RS23800 ENOG4105D44 asparaginase G3W89_RS23805 ENOG4108JQ6 ABC transporter G3W89_RS23810 ENOG4105DEF Extracellular solute-binding protein, family 5 G3W89_RS23820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W89_RS23865 ENOG4105GVR general secretion pathway protein D G3W89_RS23890 ENOG4107QHF type ii secretion system protein e G3W89_RS23895 ENOG4105D7Q type ii secretion system G3W89_RS23900 ENOG4108VAU general secretion pathway protein G G3W89_RS23955 ENOG4108IV0 ABC, transporter G3W89_RS23960 ENOG4108IUZ ABC transporter G3W89_RS23975 ENOG4105C26 Dehydrogenase G3W89_RS23985 ENOG4105G9V cytochrome C G3W89_RS23990 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G3W89_RS24035 ENOG4105CHR reductase G3W89_RS24040 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3W89_RS24045 ENOG4105CC0 LysR family Transcriptional regulator G3W89_RS24055 ENOG4105DDW LysR family Transcriptional regulator G3W89_RS24070 ENOG4106RE7 Cytochrome G3W89_RS24075 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W89_RS24155 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G3W89_RS24170 ENOG4108Z20 Acyl-transferase G3W89_RS24175 ENOG4105CD3 dihydroorotase G3W89_RS24180 ENOG4105CXT aspartate transcarbamylase G3W89_RS24185 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G3W89_RS24190 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G3W89_RS24195 ENOG4108UJU UPF0301 protein G3W89_RS24200 ENOG4105CVP deoxyribo-dipyrimidine photolyase G3W89_RS24210 ENOG4105C8Q Methyl-accepting chemotaxis G3W89_RS24220 ENOG4105M3Z response regulator G3W89_RS24225 ENOG4108UNF response regulator G3W89_RS24230 ENOG4105VCQ rubredoxin G3W89_RS24240 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G3W89_RS24245 ENOG4105DC1 bifunctional purine biosynthesis protein purh G3W89_RS24255 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G3W89_RS24260 ENOG4105W39 Membrane G3W89_RS24265 ENOG4105C3G gtp-binding protein G3W89_RS24270 ENOG4105QVC MOSC domain-containing protein G3W89_RS24275 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G3W89_RS24290 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS24335 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G3W89_RS24340 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase G3W89_RS24345 ENOG4105E8V Alpha Beta Hydrolase Fold protein G3W89_RS24350 ENOG41077RS Phosphatase G3W89_RS24365 ENOG4108HPI phosphatidate Cytidylyltransferase G3W89_RS24370 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) G3W89_RS24375 ENOG4105C9A Phoh family G3W89_RS24380 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) G3W89_RS24385 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) G3W89_RS24410 ENOG4105DR5 peptidase G3W89_RS24415 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G3W89_RS24420 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3W89_RS24425 ENOG4108YX9 iron--sulfur cluster insertion protein erpA G3W89_RS24430 ENOG4108UJD 30S ribosomal protein S9 G3W89_RS24435 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G3W89_RS24440 ENOG4105D6S protein involved in catabolism of external DNA G3W89_RS24450 ENOG4105SYT Methylenetetrahydrofolate reductase G3W89_RS24460 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G3W89_RS24470 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) G3W89_RS24500 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W89_RS24525 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W89_RS24540 ENOG4105CSH Transporter G3W89_RS24560 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W89_RS24565 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase G3W89_RS24575 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) G3W89_RS24580 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G3W89_RS24585 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G3W89_RS24600 ENOG4108IPT Naphthoate synthase G3W89_RS24610 ENOG4107QX3 carboxylase G3W89_RS24615 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS24620 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS24635 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 G3W89_RS24640 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G3W89_RS24655 ENOG4105K5B UPF0225 protein G3W89_RS24670 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS24685 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS24690 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) G3W89_RS24695 ENOG41077A9 carbonic anhydrase G3W89_RS24700 ENOG4108Z6Z Transcriptional regulator G3W89_RS24715 ENOG4105EI2 Pseudouridine synthase G3W89_RS24720 ENOG4105WH1 Two component transcriptional regulator luxr family G3W89_RS24725 ENOG4105BZU Histidine kinase G3W89_RS24730 ENOG4105CHR reductase G3W89_RS24745 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase G3W89_RS24750 ENOG4105C38 Glycyl-tRNA synthetase beta subunit G3W89_RS24755 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit G3W89_RS24760 ENOG4105HDK L-asparaginase G3W89_RS24770 ENOG4105CG3 alpha amylase, catalytic region G3W89_RS24775 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G3W89_RS24780 ENOG4108JU5 Magnesium and cobalt efflux protein G3W89_RS24800 ENOG4105F87 Dehydratase G3W89_RS24815 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS24845 ENOG4105C5H ABC transporter G3W89_RS24850 ENOG4107RZC phospholipase d G3W89_RS24855 ENOG4105CHM Aminotransferase G3W89_RS24865 ENOG4105T38 integral membrane protein G3W89_RS24870 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W89_RS24880 ENOG4108NIW Leucine export protein LeuE G3W89_RS24885 ENOG4108TGY Glutathione S-transferase G3W89_RS24890 ENOG4105JAB phenazine biosynthesis protein, phzf family G3W89_RS24910 ENOG4105F4K antigen 43 G3W89_RS24920 ENOG4105VF7 tolerance protein G3W89_RS24935 ENOG4108V1U phospholipid-binding protein G3W89_RS24950 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G3W89_RS24955 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) G3W89_RS24960 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G3W89_RS24965 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G3W89_RS24970 ENOG4105C25 Primosomal protein n' G3W89_RS24985 ENOG4105RK9 auxin efflux carrier G3W89_RS24990 ENOG4105C4R Atp-dependent dna helicase G3W89_RS25000 ENOG4105HDD phospholipase G3W89_RS25010 ENOG4105C1G acyl-Coa dehydrogenase G3W89_RS25015 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS25020 ENOG4105DND Transcriptional regulator G3W89_RS25030 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G3W89_RS25100 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS25125 ENOG4105CKT filamentous hemagglutinin G3W89_RS25135 ENOG4105CPT Alpha beta hydrolase G3W89_RS25140 ENOG4108WYP Transcriptional regulator G3W89_RS25145 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein G3W89_RS25150 ENOG4108IY8 ABC, transporter G3W89_RS25155 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W89_RS25180 ENOG4105ES5 Histidine kinase G3W89_RS25190 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G3W89_RS25200 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G3W89_RS25205 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G3W89_RS25210 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G3W89_RS25215 ENOG4108VZM 50s ribosomal protein L10 G3W89_RS25220 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) G3W89_RS25225 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) G3W89_RS25235 ENOG4105PM1 preprotein translocase subunit SecE G3W89_RS25245 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G3W89_RS25265 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G3W89_RS25270 ENOG4105DK0 Indole-3-glycerol phosphate synthase G3W89_RS25275 ENOG4107QYG anthranilate phosphoribosyltransferase G3W89_RS25280 ENOG410829K Lysine exporter protein (Lyse ygga) G3W89_RS25290 ENOG4105DDQ anthranilate synthase G3W89_RS25315 ENOG4105CHR reductase G3W89_RS25320 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS25325 ENOG4108IV0 ABC, transporter G3W89_RS25335 ENOG4105C0Z ABC transporter G3W89_RS25340 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS25345 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G3W89_RS25370 ENOG4105CHR reductase G3W89_RS25375 ENOG4106IPI cyclase, family G3W89_RS25385 ENOG4105CHU acetyl-coa acetyltransferase G3W89_RS25400 ENOG4105FUY alpha subunit G3W89_RS25430 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G3W89_RS25440 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W89_RS25450 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G3W89_RS25485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W89_RS25525 ENOG4108ZF3 Phosphatase G3W89_RS25530 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G3W89_RS25565 ENOG4105EHI Phosphonate ABC transporter, periplasmic G3W89_RS25570 ENOG4105EHI Phosphonate ABC transporter, periplasmic G3W89_RS25575 ENOG4105BZU Histidine kinase G3W89_RS25590 ENOG4108IG5 Transcriptional regulator G3W89_RS25625 ENOG4105C0Z ABC transporter G3W89_RS25630 ENOG4108IV0 ABC, transporter G3W89_RS25640 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS25645 ENOG4108Z7G MaoC domain protein dehydratase G3W89_RS25650 ENOG4105E39 Enoyl-CoA hydratase G3W89_RS25675 ENOG4105C75 arginyL-tRNA synthetase G3W89_RS25690 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA G3W89_RS25695 ENOG4108IUZ ABC transporter G3W89_RS25700 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W89_RS25705 ENOG4107RZC phospholipase d G3W89_RS25710 ENOG4105ETE Transcriptional regulator (LacI family G3W89_RS25720 ENOG4105CXK mandelate racemase muconate lactonizing G3W89_RS25740 ENOG4107V59 shikimate G3W89_RS25760 ENOG41073TP transcriptional regulator G3W89_RS25790 ENOG4105ENE Histidine kinase G3W89_RS25795 ENOG4105WH1 Two component transcriptional regulator luxr family G3W89_RS25800 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) G3W89_RS25810 ENOG4105NVB glycoside hydrolase, family 19 G3W89_RS25830 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G3W89_RS25870 ENOG4105WH1 Two component transcriptional regulator luxr family G3W89_RS25875 ENOG4105BZU Histidine kinase G3W89_RS25890 ENOG4108IMY Transcriptional regulator G3W89_RS25895 ENOG4107W7X Aldolase G3W89_RS25900 ENOG4105CH5 extracellular solute-binding protein, family 7 G3W89_RS25910 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G3W89_RS25915 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) G3W89_RS25925 ENOG4105NWN ApaG protein G3W89_RS25930 ENOG4105DJV ribulose-phosphate 3-epimerase G3W89_RS25945 ENOG4105DQE DNA ligase G3W89_RS25960 ENOG4107TYG Oxidoreductase domain-containing protein G3W89_RS25965 ENOG4105CQB FAD linked oxidase domain protein G3W89_RS25970 ENOG4108IV0 ABC, transporter G3W89_RS25975 ENOG4105CP9 extracellular ligand-binding receptor G3W89_RS25980 ENOG4105C0Z ABC transporter G3W89_RS25985 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS25990 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G3W89_RS25995 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W89_RS26000 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W89_RS26005 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter G3W89_RS26010 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W89_RS26020 ENOG4105CMT Dihydroxyacetone kinase G3W89_RS26025 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3W89_RS26030 ENOG41069M3 Transcriptional regulator G3W89_RS26035 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W89_RS26055 ENOG4105ETE Transcriptional regulator (LacI family G3W89_RS26060 ENOG4106PBJ Serine threonine-protein kinase Pkn6 G3W89_RS26105 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS26110 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W89_RS26130 ENOG4105CIH Imidazole acetol-phosphate transaminase G3W89_RS26135 ENOG4107QP3 malate synthase g G3W89_RS26160 ENOG4105ETT transcriptional Regulator, LysR family G3W89_RS26185 ENOG4107R15 K00850 6-phosphofructokinase 1 EC 2.7.1.11 G3W89_RS26200 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3W89_RS26205 ENOG4105E7A Glutamine amidotransferase G3W89_RS26225 ENOG4105D7Z glutathione synthase G3W89_RS26230 ENOG4105DKK Benzoate G3W89_RS26235 ENOG4105DFH Transport of potassium into the cell (By similarity) G3W89_RS26245 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G3W89_RS26260 ENOG4105C8T Leucyl-tRNA synthetase G3W89_RS26265 ENOG4105SG9 biopolymer transport protein, ExbD G3W89_RS26275 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G3W89_RS26280 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G3W89_RS26285 ENOG41090R7 Ferric uptake G3W89_RS26290 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) G3W89_RS26295 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN G3W89_RS26300 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA G3W89_RS26305 ENOG4105C4R Atp-dependent dna helicase G3W89_RS26310 ENOG4107QUT magnesium and cobalt transport protein CorA G3W89_RS26320 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) G3W89_RS26325 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS26330 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G3W89_RS26335 ENOG4105W8H transhydrogenase (subunit alpha G3W89_RS26345 ENOG4105EEX Two component transcriptional regulator (Winged helix family G3W89_RS26360 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G3W89_RS26370 ENOG4105DEN Luciferase family G3W89_RS26390 ENOG4105D3Q Sugar transferase G3W89_RS26420 ENOG4108MX3 Polysaccharide Biosynthesis Protein G3W89_RS26425 ENOG4108IAJ Nad-dependent epimerase dehydratase G3W89_RS26430 ENOG4107QQG Dehydrogenase G3W89_RS26450 ENOG4108UUM single-stranded DNA-binding protein G3W89_RS26455 ENOG4105CMQ Chloride channel G3W89_RS26465 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G3W89_RS26470 ENOG4105C29 acyl-CoA thioesterase G3W89_RS26495 ENOG4105MSY salicylate hydroxylase G3W89_RS26510 ENOG4108KB2 LysR family Transcriptional regulator G3W89_RS26520 ENOG4105BZU Histidine kinase G3W89_RS26530 ENOG4105ETX regulatoR G3W89_RS26535 ENOG4105ERH Fumarylacetoacetate hydrolase G3W89_RS26540 ENOG4105F1J Homogentisate 1,2-dioxygenase G3W89_RS26550 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G3W89_RS26580 ENOG4105SKN orotidine 5''-phosphate decarboxylase G3W89_RS26590 ENOG4105KEG ribosomal-protein-alanine acetyltransferase G3W89_RS26595 ENOG41072GX Peptidase M22 Glycoprotease G3W89_RS26610 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G3W89_RS26615 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G3W89_RS26620 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G3W89_RS26625 ENOG4107QR8 Thioredoxin G3W89_RS26635 ENOG4107RYR Transcriptional regulator, Crp Fnr family G3W89_RS26645 ENOG4105C8V SAICAR synthetase G3W89_RS26655 ENOG4105CA9 Pyruvate kinase G3W89_RS26660 ENOG4105BZA Phosphoglycerate kinase G3W89_RS26665 ENOG4105DUM transcriptional regulator, lysR family G3W89_RS26680 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G3W89_RS26700 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G3W89_RS26710 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G3W89_RS26720 ENOG4105C79 DNA protecting protein DprA G3W89_RS26725 ENOG4108RPN Protein smg homolog G3W89_RS26735 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3W89_RS26740 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3W89_RS26745 ENOG4105VIE preprotein translocase, subunit YajC G3W89_RS26755 ENOG4108YXU transcriptional regulator AsnC family G3W89_RS26760 ENOG4107SFI Major Facilitator superfamily G3W89_RS26765 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family G3W89_RS26790 ENOG4107TTD cytosine deaminase G3W89_RS26795 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3W89_RS26800 ENOG4105FB2 class II Aldolase G3W89_RS26805 ENOG4105G63 Type III effector Hrp-dependent G3W89_RS26810 ENOG4105ZXK Dehydrogenase G3W89_RS26820 ENOG4105C1J atp-dependent rna helicase G3W89_RS26825 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G3W89_RS26830 ENOG4105C0H protease G3W89_RS26840 ENOG4108Z86 Glutamine amidotransferase G3W89_RS26850 ENOG4105C9U ATP-dependent DNA helicase RecQ G3W89_RS26860 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G3W89_RS26890 ENOG4105DHQ Histidine kinase G3W89_RS26905 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G3W89_RS26910 ENOG4108004 Modulates RecA activity (By similarity) G3W89_RS26915 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G3W89_RS26920 ENOG4105CMV Succinyl-CoA synthetase subunit beta G3W89_RS26925 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G3W89_RS26930 ENOG4108ZCF integral membrane protein G3W89_RS26935 ENOG4108ZF3 Phosphatase G3W89_RS26945 ENOG4105F8J Adenylate Guanylate cyclase G3W89_RS26955 ENOG4105KHS type IV fimbrial pilin protein G3W89_RS26995 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G3W89_RS27000 ENOG4105ERG peptidase m48, ste24p G3W89_RS27005 ENOG41086DT Membrane protein of unknown function G3W89_RS27015 ENOG4108ZCF integral membrane protein G3W89_RS27030 ENOG4108VWS Yaeq family G3W89_RS27035 ENOG4107QTF adenylosuccinate lyase G3W89_RS27045 ENOG4108M3P Membrane G3W89_RS27050 ENOG4108U78 Glutathione S-transferase G3W89_RS27065 ENOG4108KPJ rna polymerase sigma factor G3W89_RS27070 ENOG4105K6T rare lipoprotein A G3W89_RS27075 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G3W89_RS27090 ENOG4105BZU Histidine kinase G3W89_RS27095 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W89_RS27100 ENOG4105KCK Peptidoglycan-associated lipoprotein G3W89_RS27110 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G3W89_RS27130 ENOG4108YXU transcriptional regulator AsnC family G3W89_RS27135 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G3W89_RS27140 ENOG4108RZE Tetr family transcriptional regulator G3W89_RS27145 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase G3W89_RS27180 ENOG4105CEV competence damage-inducible protein G3W89_RS27185 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G3W89_RS27195 ENOG4107JEE Short-chain dehydrogenase reductase Sdr G3W89_RS27200 ENOG4108YZY peptidylprolyl cis-trans isomerase G3W89_RS27215 ENOG4105EUB pirin domain protein G3W89_RS27225 ENOG4105CPC Aldo Keto reductase G3W89_RS27245 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3W89_RS27250 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) G3W89_RS27260 ENOG4108Q1J Extracellular solute-binding protein, family 3 G3W89_RS27265 ENOG4105DZG Dehydrogenase G3W89_RS27280 ENOG4105HSS phospholipase C G3W89_RS27285 ENOG4105C08 Histidine kinase G3W89_RS27290 ENOG4105EHU Circadian clock protein KaiC G3W89_RS27310 ENOG4105C9U ATP-dependent DNA helicase RecQ G3W89_RS27380 ENOG4108IAJ Nad-dependent epimerase dehydratase G3W89_RS27385 ENOG4105CPQ Dehydrogenase G3W89_RS27390 ENOG4105CK5 oxidoreductase G3W89_RS27425 ENOG4105BZU Histidine kinase G3W89_RS27435 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W89_RS27445 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W89_RS27450 ENOG4105WEF catalase G3W89_RS27475 ENOG4105EEF Alkane 1-monooxygenase G3W89_RS27495 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G3W89_RS27500 ENOG4108IV0 ABC, transporter G3W89_RS27505 ENOG4108IUZ ABC transporter G3W89_RS27510 ENOG4105C32 Amino acid ABC transporter (Permease) G3W89_RS27525 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W89_RS27540 ENOG4105DND Transcriptional regulator G3W89_RS27555 ENOG4105CEY Amp-dependent synthetase and ligase G3W89_RS27575 ENOG4105ECQ AraC Family Transcriptional Regulator G3W89_RS27605 ENOG4105DTQ mandelate racemase muconate lactonizing G3W89_RS27620 ENOG4105ERH Fumarylacetoacetate hydrolase G3W89_RS27625 ENOG4105EMU Dehydrogenase G3W89_RS27640 ENOG4105C0B DNA polymerase III (alpha subunit) G3W89_RS27700 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G3W89_RS27710 ENOG4107U9T Pfam:Ribonuclease_BN G3W89_RS27785 ENOG4105MSY salicylate hydroxylase G3W89_RS27795 ENOG4108RF4 Tetr family transcriptional regulator G3W89_RS27820 ENOG41061M1 UPF0337 protein G3W89_RS27850 ENOG4105CQB FAD linked oxidase domain protein G3W89_RS27860 ENOG4105C5R Aminotransferase G3W89_RS27875 ENOG4108VX5 3-methyladenine DNA glycosylase G3W89_RS27915 ENOG4105DZR Type I site-specific deoxyribonuclease G3W89_RS27935 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G3W89_RS27940 ENOG4105CV1 Transketolase (EC 2.2.1.1) G3W89_RS27945 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) G3W89_RS27950 ENOG4108S0S Nucleotidyl transferase G3W89_RS27975 ENOG4107RAQ aminopeptidase G3W89_RS28015 ENOG4105C6K Malic enzyme G3W89_RS28030 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G3W89_RS28035 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G3W89_RS28040 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) G3W89_RS28045 ENOG4105EHM Aminoglycoside phosphotransferase G3W89_RS28050 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G3W89_RS28060 ENOG4105VP5 Bacterial protein of unknown function (DUF937) G3W89_RS28065 ENOG4105DXI Major Facilitator superfamily G3W89_RS28085 ENOG4105EYW Ion transport protein G3W89_RS28090 ENOG4105DWV Homoserine O-trans-acetylase G3W89_RS28095 ENOG4105DWV Homoserine O-trans-acetylase G3W89_RS28105 ENOG4105VFU Rna-binding protein G3W89_RS28110 ENOG4107FW0 short-chain dehydrogenase reductase G3W89_RS28120 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase G3W89_RS28125 ENOG4105C2X Arabinose 5-phosphate isomerase G3W89_RS28145 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) G3W89_RS28150 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G3W89_RS28155 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G3W89_RS28160 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) G3W89_RS28185 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G3W89_RS28215 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) G3W89_RS28220 ENOG4105E4C Lytic transglycosylase catalytic G3W89_RS28225 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W89_RS28235 ENOG4105F5W AtP-binding protein G3W89_RS28240 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W89_RS28245 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) G3W89_RS28280 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G3W89_RS28325 ENOG4105C4R Atp-dependent dna helicase G3W89_RS28450 ENOG4107WNA Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3W89_RS28515 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G3W89_RS28520 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor G3W89_RS28565 ENOG4105C7H Helicase, RecD TraA family G3W89_RS28570 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G3W89_RS28635 ENOG4105DQE DNA ligase G3W89_RS28640 ENOG4105SG9 biopolymer transport protein, ExbD G3W89_RS28650 ENOG4108PAU MotA TolQ exbB proton channel G3W89_RS28705 ENOG4105C2M dna polymerase I G3W89_RS28775 ENOG4108UUM single-stranded DNA-binding protein G3W89_RS28825 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G3W89_RS28930 ENOG4105K63 Thioredoxin G3W89_RS28965 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3W89_RS29070 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G3W89_RS29090 ENOG4105F5W AtP-binding protein G3W89_RS29095 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G3W89_RS29140 ENOG4105CEC DNA methylase N-4 N-6 G3W89_RS29210 ENOG4107RH7 Nicotinate phosphoribosyltransferase G3W89_RS29285 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G3W89_RS29380 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G3W89_RS29395 ENOG4108R1E Serine threonine protein phosphatase 1 G3W89_RS29430 ENOG4105DVT helicase G3W89_RS29485 ENOG4105D7V transposase G3W89_RS29585 ENOG4105C2J ABC transporter G3W89_RS29595 ENOG4105IPI Membrane G3W89_RS29605 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W89_RS29625 ENOG4108D1K outer membrane usher protein G3W89_RS29635 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3W89_RS29660 ENOG4107S78 Band 7 protein G3W89_RS29935 ENOG4105F8V Hydrolase, tatD family G3W89_RS29975 ENOG4105D1H recombination factor protein RarA G3W89_RS30045 ENOG4105C0B DNA polymerase III (alpha subunit) G3W89_RS30055 ENOG4105DTT CRISPR-associated helicase, cas3 G3W89_RS30060 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) G3W89_RS30065 ENOG4105PWE CRISPR-associated protein cas2 G3W89_RS30125 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G3W89_RS30370 ENOG4107RA1 nh(3)-dependent nad( ) synthetase G3W89_RS30395 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G3W89_RS30435 ENOG4105BZU Histidine kinase G3W89_RS30465 ENOG4105CYB regulatoR G3W89_RS30520 ENOG4108ZUW Major pilin subunit G3W89_RS30655 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G3W89_RS30680 ENOG4105F5W AtP-binding protein G3W89_RS30840 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3W89_RS30860 ENOG4107RQ0 Maleylacetate reductase G3W89_RS30925 ENOG4105KRG Aromatic-ring-hydroxylating dioxygenase beta subunit G3W89_RS30940 ENOG4105KRG Aromatic-ring-hydroxylating dioxygenase beta subunit G3W89_RS30950 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G3W89_RS30985 ENOG4108KBP metal-dependent protein hydrolase G3W89_RS31015 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation G3W89_RS31095 ENOG4105EIN peptidylprolyl cis-trans isomerase G3W89_RS31200 ENOG4106IJN integrase catalytic domain-containing protein G3W89_RS31330 ENOG4105C8N cysteinyl-tRNA synthetase G3W89_RS31455 ENOG4105CVR type I restriction-modification system G3W89_RS31555 ENOG4105KIR Thiol-disulfide oxidoreductase dcc G3W89_RS31570 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G3W89_RS31620 ENOG4105EEQ Na H antiporter G3W89_RS31630 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G3W89_RS31665 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G3W89_RS31750 ENOG4108V1T peptidylprolyl cis-trans isomerase G3W89_RS31760 ENOG4105K70 DNA-binding protein G3W89_RS31820 ENOG4105BZU Histidine kinase G3W89_RS31925 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3W89_RS31980 ENOG4105C9U ATP-dependent DNA helicase RecQ G3W89_RS32060 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G3W89_RS32085 ENOG4108Z12 YiaAB two helix domain-containing protein G3W89_RS32355 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G3W89_RS32360 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) G3W89_RS32400 ENOG4107S1Q Phosphatase G3W89_RS32405 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G3W89_RS32430 ENOG4107QHF type ii secretion system protein e G3W89_RS32485 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) G3W89_RS32500 ENOG4105CZX twitching motility protein G3W89_RS32520 ENOG4107QHF type ii secretion system protein e G3W89_RS32650 ENOG4105DVT helicase G3W89_RS32665 ENOG4107QJE Chromosome Partitioning Protein G3W89_RS32735 ENOG4105CMA conjugation trbi family protein G3W89_RS32775 ENOG4106D0Q Type IV secretion system protein VirB2 G3W89_RS32865 ENOG4105W5Q DNA repair protein (RadC