locus-tag class description WDLP6_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) WDLP6_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WDLP6_RS00015 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WDLP6_RS00030 ENOG4107RN3 metallophosphoesterase WDLP6_RS00040 ENOG41061N2 exported protein WDLP6_RS00050 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) WDLP6_RS00055 ENOG4107UXM Membrane WDLP6_RS00060 ENOG4105DZQ phospholipase D Transphosphatidylase WDLP6_RS00065 ENOG4105X23 Endonuclease Exonuclease phosphatase WDLP6_RS00085 ENOG4105EUB pirin domain protein WDLP6_RS00090 ENOG410633P Hydantoin racemase WDLP6_RS00100 ENOG4105F38 ABC transporter, permease WDLP6_RS00110 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WDLP6_RS00115 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase WDLP6_RS00135 ENOG4108JQC penicillin-binding protein 1A WDLP6_RS00140 ENOG4105EB3 Histidine kinase WDLP6_RS00145 ENOG4105E3W Two component transcriptional regulator (Winged helix family WDLP6_RS00155 ENOG4105C59 p-type ATPase WDLP6_RS00165 ENOG4105ECM Sensor protein basS pmrB WDLP6_RS00170 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WDLP6_RS00175 ENOG4105CBP Major Facilitator WDLP6_RS00180 ENOG4108K3A Glutathione S-transferase WDLP6_RS00195 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) WDLP6_RS00200 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) WDLP6_RS00210 ENOG4107QJE Chromosome Partitioning Protein WDLP6_RS00220 ENOG4105FA0 parb-like partition protein WDLP6_RS00230 ENOG4105CQB FAD linked oxidase domain protein WDLP6_RS00235 ENOG4108WBT adenosyltransferase WDLP6_RS00270 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) WDLP6_RS00275 ENOG4107QMS site-determining protein WDLP6_RS00280 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) WDLP6_RS00290 ENOG4105C2W permease WDLP6_RS00295 ENOG4105KA0 thioesterase Superfamily protein WDLP6_RS00310 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WDLP6_RS00315 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS00340 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) WDLP6_RS00345 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme WDLP6_RS00370 ENOG4105EVZ LysR family transcriptional regulator WDLP6_RS00380 ENOG4105F8J Adenylate Guanylate cyclase WDLP6_RS00395 ENOG4105CAF HipA N-terminal domain protein WDLP6_RS00400 ENOG4105C2W permease WDLP6_RS00405 ENOG4107SKI cobyrinic Acid a,c-diamide synthase WDLP6_RS00430 ENOG4108IV0 ABC, transporter WDLP6_RS00435 ENOG4105C0Z ABC transporter WDLP6_RS00445 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS00455 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WDLP6_RS00475 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) WDLP6_RS00500 ENOG4105DDW LysR family Transcriptional regulator WDLP6_RS00540 ENOG4105BZU Histidine kinase WDLP6_RS00545 ENOG4106T14 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) WDLP6_RS00555 ENOG4105DTD Dehydrogenase WDLP6_RS00575 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WDLP6_RS00590 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WDLP6_RS00595 ENOG4105EBM Alpha Beta Hydrolase Fold protein WDLP6_RS00600 ENOG4105K89 arsenate reductase WDLP6_RS00645 ENOG4105F38 ABC transporter, permease WDLP6_RS00650 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component WDLP6_RS00665 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) WDLP6_RS00675 ENOG4107RUE extracellular solute-binding protein family 1 WDLP6_RS00680 ENOG4107S9D Alpha beta hydrolase WDLP6_RS00690 ENOG4105CI2 imidazolone-5-propionate hydrolase WDLP6_RS00720 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) WDLP6_RS00745 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WDLP6_RS00750 ENOG4105K4H Nlp p60 protein WDLP6_RS00775 ENOG4105JSC dimethylmenaquinone methyltransferase WDLP6_RS00785 ENOG4107R6F Alpha Beta Hydrolase Fold protein WDLP6_RS00790 ENOG4105BZU Histidine kinase WDLP6_RS00800 ENOG4105DQE DNA ligase WDLP6_RS00810 ENOG4105FDF Could be involved in DNA repair (By similarity) WDLP6_RS00815 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WDLP6_RS00845 ENOG4105VFU Rna-binding protein WDLP6_RS00865 ENOG4105XDF Protein of unknown function (DUF1272) WDLP6_RS00880 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component WDLP6_RS00890 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS00900 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family WDLP6_RS00905 ENOG4108KSA LysR family transcriptional regulator WDLP6_RS00910 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS00920 ENOG4105DND Transcriptional regulator WDLP6_RS00945 ENOG4105CHR reductase WDLP6_RS00965 ENOG4105BZU Histidine kinase WDLP6_RS00970 ENOG4105BZU Histidine kinase WDLP6_RS00980 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase WDLP6_RS00985 ENOG4105FUA antagonist WDLP6_RS00990 ENOG4107MMM Anti-sigma-factor antagonist WDLP6_RS01000 ENOG4105FAA peptidase M23 WDLP6_RS01020 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WDLP6_RS01040 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) WDLP6_RS01045 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WDLP6_RS01050 ENOG41086DT Membrane protein of unknown function WDLP6_RS01070 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WDLP6_RS01075 ENOG4105D3R alkyl hydroperoxide reductase WDLP6_RS01080 ENOG4105ETT transcriptional Regulator, LysR family WDLP6_RS01085 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS01090 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS01110 ENOG4105EMU Dehydrogenase WDLP6_RS01150 ENOG4105ETE Transcriptional regulator (LacI family WDLP6_RS01155 ENOG4105D9P serine threonine protein kinase WDLP6_RS01170 ENOG4105CSV Glutaminase WDLP6_RS01185 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) WDLP6_RS01215 ENOG4105DGI Alkaline phosphatase WDLP6_RS01235 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) WDLP6_RS01240 ENOG4105C7B Threonine dehydratase WDLP6_RS01260 ENOG4105C9U ATP-dependent DNA helicase RecQ WDLP6_RS01280 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component WDLP6_RS01290 ENOG4105CZE histidine utilization repressor WDLP6_RS01295 ENOG4105C84 Histidine ammonia-lyase WDLP6_RS01300 ENOG4105CGP Urocanate hydratase WDLP6_RS01325 ENOG4105CI2 imidazolone-5-propionate hydrolase WDLP6_RS01355 ENOG4105C3R Methionine synthase WDLP6_RS01365 ENOG4105F52 Transcriptional regulator WDLP6_RS01380 ENOG4105C3R Methionine synthase WDLP6_RS01385 ENOG41063ZV WDLP6_RS01390 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 WDLP6_RS01425 ENOG4105CKT filamentous hemagglutinin WDLP6_RS01435 ENOG4108W9H Tetr family transcriptional regulator WDLP6_RS01440 ENOG4105DP0 ferredoxin-NADP reductase WDLP6_RS01475 ENOG4105C0Z ABC transporter WDLP6_RS01480 ENOG4108IV0 ABC, transporter WDLP6_RS01485 ENOG4108RWI nicotinamidase WDLP6_RS01490 ENOG4108XHQ (2Fe-2S)-binding domain protein WDLP6_RS01495 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding WDLP6_RS01525 ENOG4105C0P Mg chelatase subunit ChlI WDLP6_RS01535 ENOG4108YZA Nitrogen regulatory protein pii WDLP6_RS01540 ENOG4105BZU Histidine kinase WDLP6_RS01550 ENOG4105EU8 FAD linked oxidase domain protein WDLP6_RS01555 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) WDLP6_RS01570 ENOG4108V06 Glutathione peroxidase WDLP6_RS01580 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) WDLP6_RS01585 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WDLP6_RS01590 ENOG4105D2K citrate carrier protein WDLP6_RS01595 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WDLP6_RS01600 ENOG4105MP9 class II Aldolase WDLP6_RS01610 ENOG4105C01 Dihydroxy-acid dehydratase WDLP6_RS01630 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase WDLP6_RS01635 ENOG4105C26 Dehydrogenase WDLP6_RS01655 ENOG4108V8F Transcriptional regulator, MarR family WDLP6_RS01665 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein WDLP6_RS01670 ENOG4105CHR reductase WDLP6_RS01675 ENOG4105CHR reductase WDLP6_RS01680 ENOG4108IV0 ABC, transporter WDLP6_RS01685 ENOG4105C0Z ABC transporter WDLP6_RS01690 ENOG4105CF8 branched-chain amino acid ABC transporter, permease WDLP6_RS01695 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS01705 ENOG4105CHR reductase WDLP6_RS01715 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) WDLP6_RS01720 ENOG4105C94 Transporter WDLP6_RS01730 ENOG4105DH7 May be involved in recombination (By similarity) WDLP6_RS01735 ENOG4105CM2 brancheD-chain amino acid aminotransferase WDLP6_RS01755 ENOG4105E0F Histidine kinase WDLP6_RS01760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WDLP6_RS01800 ENOG4105EMU Dehydrogenase WDLP6_RS01810 ENOG41061H0 Monooxygenase WDLP6_RS01815 ENOG4105F04 LysR family Transcriptional regulator WDLP6_RS01820 ENOG4105CGK Exodeoxyribonuclease III WDLP6_RS01825 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) WDLP6_RS01835 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) WDLP6_RS01840 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WDLP6_RS01845 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) WDLP6_RS01865 ENOG4105CJN penicillin-binding protein WDLP6_RS01880 ENOG4105DHJ ABC, transporter WDLP6_RS01900 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein WDLP6_RS01905 ENOG4105CYX Short-chain dehydrogenase reductase Sdr WDLP6_RS01925 ENOG4105D7N magnesium and cobalt transport protein CorA WDLP6_RS01930 ENOG4105D52 delta-aminolevulinic acid dehydratase WDLP6_RS01935 ENOG4108YXA Membrane WDLP6_RS01945 ENOG4105NZG Ferredoxin WDLP6_RS01950 ENOG4105DHZ alpha beta WDLP6_RS01955 ENOG4105DZ1 carboxypeptidase WDLP6_RS01960 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) WDLP6_RS01965 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) WDLP6_RS01970 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) WDLP6_RS01975 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) WDLP6_RS01980 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) WDLP6_RS01995 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) WDLP6_RS02000 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) WDLP6_RS02005 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) WDLP6_RS02010 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity WDLP6_RS02015 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) WDLP6_RS02020 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) WDLP6_RS02025 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) WDLP6_RS02030 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) WDLP6_RS02035 ENOG41084PQ 50s ribosomal protein l29 WDLP6_RS02040 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal WDLP6_RS02060 ENOG4105T86 cytochrome C WDLP6_RS02065 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WDLP6_RS02080 ENOG41080Z8 PHOSPHOCARRIER protein WDLP6_RS02085 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) WDLP6_RS02100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WDLP6_RS02105 ENOG41062D9 Histidine kinase WDLP6_RS02110 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein WDLP6_RS02120 ENOG4105F4P )-transporter WDLP6_RS02125 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS02130 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) WDLP6_RS02135 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) WDLP6_RS02140 ENOG4105F0I Aminotransferase WDLP6_RS02150 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) WDLP6_RS02155 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WDLP6_RS02160 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WDLP6_RS02165 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WDLP6_RS02170 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) WDLP6_RS02175 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) WDLP6_RS02180 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) WDLP6_RS02185 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) WDLP6_RS02200 ENOG4105CNN ABC, transporter WDLP6_RS02205 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator WDLP6_RS02210 ENOG4105CIB oxidoreductase Domain protein WDLP6_RS02250 ENOG4107T0X DNA ligase WDLP6_RS02255 ENOG4107T0X DNA ligase WDLP6_RS02260 ENOG4107QRT dEAD DEAH box helicase WDLP6_RS02315 ENOG4105ENJ RND efflux system, outer membrane lipoprotein WDLP6_RS02320 ENOG4105BZS acriflavin resistance protein WDLP6_RS02330 ENOG4108IG5 Transcriptional regulator WDLP6_RS02355 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WDLP6_RS02370 ENOG4105CSH Transporter WDLP6_RS02380 ENOG4108Z4U Ferredoxin WDLP6_RS02395 ENOG4107EXU Short-chain dehydrogenase reductase Sdr WDLP6_RS02400 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase WDLP6_RS02420 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein WDLP6_RS02435 ENOG4105C26 Dehydrogenase WDLP6_RS02440 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator WDLP6_RS02445 ENOG4105DFW ABC transporter WDLP6_RS02455 ENOG4108HWW ABC transporter WDLP6_RS02460 ENOG4105C2J ABC transporter WDLP6_RS02465 ENOG4107R9N ABC transporter WDLP6_RS02470 ENOG41062B0 ABC transporter, permease WDLP6_RS02505 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) WDLP6_RS02610 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WDLP6_RS02620 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) WDLP6_RS02625 ENOG41082RQ UPF0102 protein WDLP6_RS02630 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) WDLP6_RS02640 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WDLP6_RS02645 ENOG4105CZX twitching motility protein WDLP6_RS02650 ENOG4105CZX twitching motility protein WDLP6_RS02655 ENOG4105DFA alanine racemase domain protein WDLP6_RS02660 ENOG4105EW9 transcriptional regulator AsnC family WDLP6_RS02665 ENOG4105D82 Glutamate dehydrogenase WDLP6_RS02690 ENOG4105CYW agmatinase WDLP6_RS02700 ENOG4105S7S phosphonate abc transporter WDLP6_RS02705 ENOG4105D5T phosphonate abc transporter WDLP6_RS02710 ENOG4105EHI Phosphonate ABC transporter, periplasmic WDLP6_RS02715 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process WDLP6_RS02725 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) WDLP6_RS02760 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WDLP6_RS02775 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS02780 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WDLP6_RS02795 ENOG41067MG lrgb family WDLP6_RS02800 ENOG4105VAW lrga family WDLP6_RS02805 ENOG4105CQB FAD linked oxidase domain protein WDLP6_RS02815 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WDLP6_RS02870 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase WDLP6_RS02920 ENOG4105CH2 amidohydrolase WDLP6_RS02950 ENOG4105MH5 phosphoesterase PA-phosphatase related protein WDLP6_RS02985 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) WDLP6_RS02990 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) WDLP6_RS02995 ENOG4105CB5 ATP-dependent DNA helicase recG WDLP6_RS03000 ENOG4105C5Q Transcriptional regulator WDLP6_RS03010 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) WDLP6_RS03015 ENOG4105II7 pyrroline-5-carboxylate reductase WDLP6_RS03020 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) WDLP6_RS03025 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) WDLP6_RS03030 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits WDLP6_RS03035 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) WDLP6_RS03040 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) WDLP6_RS03045 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) WDLP6_RS03050 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) WDLP6_RS03055 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) WDLP6_RS03060 ENOG4105VPB 50S ribosomal protein L30 WDLP6_RS03065 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) WDLP6_RS03070 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WDLP6_RS03080 ENOG41067V7 50S ribosomal protein L36 WDLP6_RS03085 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits WDLP6_RS03090 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) WDLP6_RS03095 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) WDLP6_RS03100 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WDLP6_RS03105 ENOG4108ZT0 50S ribosomal protein l17 WDLP6_RS03125 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS03130 ENOG4108UKI Enoyl-CoA hydratase WDLP6_RS03145 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase WDLP6_RS03160 ENOG4105EJC lysr family transcriptional regulator WDLP6_RS03165 ENOG4105F6U Short-chain dehydrogenase reductase Sdr WDLP6_RS03170 ENOG4105CPP Dehydrogenase, E1 component WDLP6_RS03175 ENOG4107RUY (E1 component), alpha subunit WDLP6_RS03210 ENOG4105BZU Histidine kinase WDLP6_RS03225 ENOG4107R7Y intracellular protease Pfpi family WDLP6_RS03230 ENOG4105DZS Phenylacetate-CoA ligase WDLP6_RS03235 ENOG4108IV0 ABC, transporter WDLP6_RS03255 ENOG4105C0Z ABC transporter WDLP6_RS03260 ENOG4108IQE Amp-dependent synthetase and ligase WDLP6_RS03265 ENOG4105IJJ transcriptional regulator, crp fnr family WDLP6_RS03275 ENOG410904N short-chain dehydrogenase reductase WDLP6_RS03295 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) WDLP6_RS03300 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) WDLP6_RS03305 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) WDLP6_RS03310 ENOG4105C08 Histidine kinase WDLP6_RS03315 ENOG4105EEX Two component transcriptional regulator (Winged helix family WDLP6_RS03320 ENOG4105FE9 pseudouridine synthase WDLP6_RS03325 ENOG4105XJC Two component transcriptional regulator (Winged helix family WDLP6_RS03330 ENOG4105DHQ Histidine kinase WDLP6_RS03380 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) WDLP6_RS03385 ENOG4106A3M Cytochrome p-450 WDLP6_RS03390 ENOG4105E27 serine threonine protein kinase WDLP6_RS03400 ENOG4108ZHJ Organic hydroperoxide resistance protein WDLP6_RS03405 ENOG4105K56 Transcriptional regulator WDLP6_RS03415 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WDLP6_RS03420 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR WDLP6_RS03445 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS03455 ENOG4105C0Z ABC transporter WDLP6_RS03460 ENOG4108IV0 ABC, transporter WDLP6_RS03495 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WDLP6_RS03500 ENOG4105D7T ABC transporter WDLP6_RS03550 ENOG4107S78 Band 7 protein WDLP6_RS03560 ENOG4105EQN UPF0261 protein WDLP6_RS03565 ENOG4105C0Z ABC transporter WDLP6_RS03590 ENOG4105CI2 imidazolone-5-propionate hydrolase WDLP6_RS03595 ENOG4105CI2 imidazolone-5-propionate hydrolase WDLP6_RS03600 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) WDLP6_RS03605 ENOG4105ERH Fumarylacetoacetate hydrolase WDLP6_RS03635 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) WDLP6_RS03640 ENOG4109066 lysm domain bon superfamily protein WDLP6_RS03665 ENOG4105CH5 extracellular solute-binding protein, family 7 WDLP6_RS03675 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS03675 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS03690 ENOG4105DC8 reductase WDLP6_RS03705 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WDLP6_RS03710 ENOG4105FYV Amp nucleosidase WDLP6_RS03720 ENOG4108ZHR arsR family transcriptional regulator WDLP6_RS03740 ENOG4105HEI LysR family (Transcriptional regulator WDLP6_RS03745 ENOG4105CJ1 ABC, transporter WDLP6_RS03760 ENOG4106BRA Membrane WDLP6_RS03770 ENOG4105CH2 amidohydrolase WDLP6_RS03785 ENOG4108J2R molybdopterin oxidoreductase WDLP6_RS03825 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase WDLP6_RS03835 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase WDLP6_RS03855 ENOG4105K64 Glycosyl transferase, family 2 WDLP6_RS03865 ENOG4108UW5 maltose o-acetyltransferase WDLP6_RS03875 ENOG4105C0K Gdp-mannose 4,6-dehydratase WDLP6_RS03900 ENOG4105CJT Mannose-1-phosphate guanylyltransferase WDLP6_RS03905 ENOG4105EXC Acyl-transferase WDLP6_RS03930 ENOG4105CAS nag kinase WDLP6_RS03940 ENOG4105CMR udp-glucose 4-epimerase WDLP6_RS03965 ENOG410829K Lysine exporter protein (Lyse ygga) WDLP6_RS03980 ENOG4105IPI Membrane WDLP6_RS03995 ENOG4108ZCF integral membrane protein WDLP6_RS04030 ENOG4105E7U AraC family transcriptional regulator WDLP6_RS04045 ENOG4105CYM Glutathione S-transferase WDLP6_RS04065 ENOG4105BZU Histidine kinase WDLP6_RS04070 ENOG4105DG4 malate L-lactate dehydrogenase WDLP6_RS04075 ENOG4105CTX dehydratase WDLP6_RS04080 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS04090 ENOG4108ERU trap dicarboxylate transporter subunit DctP WDLP6_RS04095 ENOG4107YCY Transcriptional regulator WDLP6_RS04100 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr WDLP6_RS04105 ENOG4106517 Short-chain dehydrogenase reductase Sdr WDLP6_RS04110 ENOG4105ERH Fumarylacetoacetate hydrolase WDLP6_RS04115 ENOG4105C26 Dehydrogenase WDLP6_RS04120 ENOG4105EXG Transcriptional regulator WDLP6_RS04125 ENOG4105FDP GntR family transcriptional regulator WDLP6_RS04130 ENOG4105CP9 extracellular ligand-binding receptor WDLP6_RS04135 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS04140 ENOG4105CF8 branched-chain amino acid ABC transporter, permease WDLP6_RS04145 ENOG4105C0Z ABC transporter WDLP6_RS04150 ENOG4108IV0 ABC, transporter WDLP6_RS04160 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS04165 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS04210 ENOG4105CSU acyl-Coa dehydrogenase WDLP6_RS04230 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS04240 ENOG41060WC Enoyl-CoA hydratase WDLP6_RS04245 ENOG4105NAU thioesterase Superfamily protein WDLP6_RS04250 ENOG4108JJ7 ABC transporter WDLP6_RS04255 ENOG4105C5I Dehydrogenase WDLP6_RS04265 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS04270 ENOG4105CNN ABC, transporter WDLP6_RS04275 ENOG4105C0Z ABC transporter WDLP6_RS04280 ENOG4108IV0 ABC, transporter WDLP6_RS04290 ENOG4105RE0 Asp Glu hydantoin racemase WDLP6_RS04305 ENOG4108UAU isochorismatase WDLP6_RS04315 ENOG4107YNJ LysR family Transcriptional regulator WDLP6_RS04320 ENOG4107RP9 extracellular solute-binding protein, family 3 WDLP6_RS04325 ENOG4105EAD ABC transporter WDLP6_RS04330 ENOG4105DRP amino acid AbC transporter WDLP6_RS04335 ENOG4105CDA abc transporter atp-binding protein WDLP6_RS04340 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit WDLP6_RS04345 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS04355 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS04360 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS04365 ENOG4105CC9 acyl-Coa dehydrogenase WDLP6_RS04370 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS04375 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WDLP6_RS04380 ENOG4105CBN LysR family transcriptional regulator WDLP6_RS04395 ENOG4105C8Q Methyl-accepting chemotaxis WDLP6_RS04400 ENOG4108JQ1 Dehydrogenase WDLP6_RS04405 ENOG4108TY5 Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis WDLP6_RS04410 ENOG4105GAK amidohydrolase 2 WDLP6_RS04420 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS04425 ENOG4108JQ1 Dehydrogenase WDLP6_RS04430 ENOG4105JSC dimethylmenaquinone methyltransferase WDLP6_RS04450 ENOG4107RSM transcriptional regulator WDLP6_RS04465 ENOG4105EKE dihydroorotase WDLP6_RS04505 ENOG4107HP6 Transcriptional regulator WDLP6_RS04510 ENOG4105D0M Protease HtpX homolog WDLP6_RS04515 ENOG4105DZ0 fad dependent oxidoreductase WDLP6_RS04525 ENOG4105FE9 pseudouridine synthase WDLP6_RS04540 ENOG4107R0V Pyruvate dehydrogenase WDLP6_RS04550 ENOG4105CPP Dehydrogenase, E1 component WDLP6_RS04555 ENOG4107QSN dihydrolipoamide acetyltransferase WDLP6_RS04565 ENOG4107QX8 SPFH domain, Band 7 family protein WDLP6_RS04570 ENOG4105D7N magnesium and cobalt transport protein CorA WDLP6_RS04590 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS04615 ENOG4105E1J oxidoreductase WDLP6_RS04625 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) WDLP6_RS04640 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WDLP6_RS04645 ENOG4105DR4 Methyltransferase WDLP6_RS04650 ENOG4105CKI cobalamin synthesis protein WDLP6_RS04665 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) WDLP6_RS04670 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) WDLP6_RS04675 ENOG4108V6E Cell division protein mraZ WDLP6_RS04680 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) WDLP6_RS04690 ENOG4105CJN penicillin-binding protein WDLP6_RS04695 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) WDLP6_RS04700 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) WDLP6_RS04705 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) WDLP6_RS04710 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) WDLP6_RS04715 ENOG4105CNI cell division protein FtsW WDLP6_RS04720 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) WDLP6_RS04725 ENOG4105DFU Cell wall formation (By similarity) WDLP6_RS04730 ENOG4105CPF Cell wall formation (By similarity) WDLP6_RS04735 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) WDLP6_RS04740 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) WDLP6_RS04745 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) WDLP6_RS04750 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WDLP6_RS04755 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase WDLP6_RS04765 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) WDLP6_RS04770 ENOG4105K6V RNA polymerase WDLP6_RS04790 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) WDLP6_RS04795 ENOG4105KNE Phosphatidate cytidylyltransferase WDLP6_RS04860 ENOG4105E2X shikimate dehydrogenase WDLP6_RS04870 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) WDLP6_RS04875 ENOG4105IPS esterase WDLP6_RS04880 ENOG4105CNI cell division protein FtsW WDLP6_RS04885 ENOG4105D1U peptidase U62 modulator of DNA gyrase WDLP6_RS04890 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WDLP6_RS04900 ENOG4105DFU Cell wall formation (By similarity) WDLP6_RS04910 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WDLP6_RS04915 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein WDLP6_RS04920 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WDLP6_RS04925 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) WDLP6_RS04935 ENOG4107T4Z adenosine kinase WDLP6_RS04945 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WDLP6_RS04950 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WDLP6_RS04960 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WDLP6_RS04965 ENOG4107TUY Histidine kinase WDLP6_RS04980 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY WDLP6_RS04985 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) WDLP6_RS04995 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WDLP6_RS05005 ENOG4107WP9 Histidine kinase WDLP6_RS05010 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) WDLP6_RS05020 ENOG4105ENT Efflux transporter rnd family, mfp subunit WDLP6_RS05025 ENOG4105BZS acriflavin resistance protein WDLP6_RS05070 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) WDLP6_RS05080 ENOG4105FGE Short-chain dehydrogenase reductase Sdr WDLP6_RS05090 ENOG4105E2B Taurine dioxygenase WDLP6_RS05105 ENOG4105M0Y WDLP6_RS05130 ENOG4105CHR reductase WDLP6_RS05140 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WDLP6_RS05155 ENOG4105BZP glycoside hydrolase 15-related WDLP6_RS05160 ENOG4108K4C ec 3.1.3.12 WDLP6_RS05165 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate WDLP6_RS05175 ENOG4108302 MgtC SapB transporter WDLP6_RS05180 ENOG4105E4C Lytic transglycosylase catalytic WDLP6_RS05185 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase WDLP6_RS05190 ENOG4105ETT transcriptional Regulator, LysR family WDLP6_RS05205 ENOG4105DS0 Transcriptional regulator, Crp Fnr family WDLP6_RS05225 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) WDLP6_RS05250 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein WDLP6_RS05255 ENOG4105H9W Short-chain dehydrogenase reductase Sdr WDLP6_RS05265 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS05270 ENOG4105C0Z ABC transporter WDLP6_RS05275 ENOG4108IV0 ABC, transporter WDLP6_RS05295 ENOG4107QP7 CoA-transferase subunit A WDLP6_RS05305 ENOG4108IPJ Membrane WDLP6_RS05310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WDLP6_RS05325 ENOG4105PDP Short chain dehydrogenase WDLP6_RS05335 ENOG4108Z9W Outer membrane porin WDLP6_RS05355 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) WDLP6_RS05360 ENOG4105CPU Monooxygenase WDLP6_RS05375 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS05385 ENOG4105CBX hi0933 family WDLP6_RS05395 ENOG4105E2X shikimate dehydrogenase WDLP6_RS05400 ENOG4105EBM Alpha Beta Hydrolase Fold protein WDLP6_RS05535 ENOG4108UAU isochorismatase WDLP6_RS05545 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS05555 ENOG4105C0Z ABC transporter WDLP6_RS05560 ENOG4108IV0 ABC, transporter WDLP6_RS05600 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS05615 ENOG4105CHR reductase WDLP6_RS05620 ENOG4105R1U AraC Family Transcriptional Regulator WDLP6_RS05635 ENOG4105Y49 secretion protein, HlyD family WDLP6_RS05645 ENOG4105CR8 Transcriptional regulator WDLP6_RS05650 ENOG4108UAU isochorismatase WDLP6_RS05655 ENOG4105MSY salicylate hydroxylase WDLP6_RS05660 ENOG4107YV9 domain protein WDLP6_RS05705 ENOG4108M9J MaoC like domain protein WDLP6_RS05720 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase WDLP6_RS05725 ENOG4105CK2 sodium dicarboxylate symporter WDLP6_RS05730 ENOG4105F04 LysR family Transcriptional regulator WDLP6_RS05740 ENOG4105C7F AcnD-accessory protein PrpF WDLP6_RS05745 ENOG4108M0I Transcriptional regulator WDLP6_RS05755 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase WDLP6_RS05760 ENOG4108HR6 Dehydrogenase WDLP6_RS05770 ENOG4105C7W Xanthine dehydrogenase WDLP6_RS05775 ENOG4105CKI cobalamin synthesis protein WDLP6_RS05795 ENOG4105C2W permease WDLP6_RS05800 ENOG4108JQ9 ABC transporter WDLP6_RS05805 ENOG4105UIB (ABC) transporter WDLP6_RS05850 ENOG4105C0Z ABC transporter WDLP6_RS05855 ENOG4108IV0 ABC, transporter WDLP6_RS05860 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS05870 ENOG4105CHR reductase WDLP6_RS05885 ENOG4108IV0 ABC, transporter WDLP6_RS05890 ENOG4105C0Z ABC transporter WDLP6_RS05905 ENOG4105CAD extracellular ligand-binding receptor WDLP6_RS05915 ENOG4107Z7P Ferredoxin WDLP6_RS05935 ENOG4105HEI LysR family (Transcriptional regulator WDLP6_RS05940 ENOG4108RYK Nad-dependent epimerase dehydratase WDLP6_RS05970 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) WDLP6_RS05980 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WDLP6_RS05990 ENOG4105CC0 LysR family Transcriptional regulator WDLP6_RS06005 ENOG4105CS1 NAD(P)H quinone oxidoreductase WDLP6_RS06025 ENOG4105EUF amidase EC 3.5.1.4 WDLP6_RS06040 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WDLP6_RS06050 ENOG4105CF7 AraC family transcriptional regulator WDLP6_RS06055 ENOG4108MJI response regulator WDLP6_RS06075 ENOG4105JGF anti-sigma regulatory factor serine threonine protein kinase WDLP6_RS06110 ENOG4105DS1 cytochrome b561 WDLP6_RS06115 ENOG4105EQ0 Major Facilitator superfamily WDLP6_RS06120 ENOG4105HEI LysR family (Transcriptional regulator WDLP6_RS06135 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) WDLP6_RS06140 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) WDLP6_RS06155 ENOG4105CG3 alpha amylase, catalytic region WDLP6_RS06160 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) WDLP6_RS06165 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) WDLP6_RS06170 ENOG4105CN2 monooxygenase, FAD-binding WDLP6_RS06205 ENOG4105BZ1 (ABC) transporter WDLP6_RS06215 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) WDLP6_RS06220 ENOG4105CQ0 ABC transporter WDLP6_RS06230 ENOG4105D7Q type ii secretion system WDLP6_RS06240 ENOG4107QHF type ii secretion system protein e WDLP6_RS06285 ENOG4108VAU general secretion pathway protein G WDLP6_RS06295 ENOG4105C7B Threonine dehydratase WDLP6_RS06300 ENOG4108UKZ OsmC family WDLP6_RS06305 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) WDLP6_RS06310 ENOG4108Z9W Outer membrane porin WDLP6_RS06320 ENOG4105CH2 amidohydrolase WDLP6_RS06325 ENOG4105DEF Extracellular solute-binding protein, family 5 WDLP6_RS06330 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WDLP6_RS06335 ENOG4105C3U ABC transporter WDLP6_RS06340 ENOG4108JQ7 (ABC) transporter WDLP6_RS06345 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase WDLP6_RS06360 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) WDLP6_RS06365 ENOG4107QP8 phosphohexose isomerase WDLP6_RS06375 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) WDLP6_RS06380 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) WDLP6_RS06395 ENOG4105CHB tonB-dependent Receptor WDLP6_RS06405 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP WDLP6_RS06415 ENOG4105D1S lipid A biosynthesis WDLP6_RS06425 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) WDLP6_RS06430 ENOG4106RE7 Cytochrome WDLP6_RS06445 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) WDLP6_RS06450 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) WDLP6_RS06465 ENOG4105XQ6 frataxin-like protein WDLP6_RS06470 ENOG4108JQC penicillin-binding protein 1A WDLP6_RS06495 ENOG4105E4G Type IV pilus WDLP6_RS06500 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) WDLP6_RS06510 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein WDLP6_RS06545 ENOG4105DHJ ABC, transporter WDLP6_RS06550 ENOG4105CY3 ABC transporter, permease WDLP6_RS06555 ENOG4107PE3 Mammalian cell entry related domain protein WDLP6_RS06575 ENOG4105DA5 (ABC) transporter WDLP6_RS06580 ENOG4105E3A (ABC) transporter WDLP6_RS06585 ENOG4105VFK BolA family WDLP6_RS06590 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) WDLP6_RS06595 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) WDLP6_RS06610 ENOG4105CIH Imidazole acetol-phosphate transaminase WDLP6_RS06615 ENOG4105ECC imidazole-glycerol-phosphate dehydratase WDLP6_RS06625 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase WDLP6_RS06635 ENOG4105DSB aldose 1-epimerase WDLP6_RS06640 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) WDLP6_RS06645 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase WDLP6_RS06650 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase WDLP6_RS06660 ENOG4107YU2 histidine triad (hIT) protein WDLP6_RS06665 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) WDLP6_RS06670 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) WDLP6_RS06675 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) WDLP6_RS06680 ENOG4105C0H protease WDLP6_RS06685 ENOG4107QNR UPF0135 protein WDLP6_RS06690 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) WDLP6_RS06695 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) WDLP6_RS06700 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) WDLP6_RS06705 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) WDLP6_RS06710 ENOG4105EIX cytochrome c1 WDLP6_RS06715 ENOG4107MKT Stringent starvation protein a WDLP6_RS06720 ENOG4105KB2 stringent starvation protein b WDLP6_RS06740 ENOG4105D6J arsenicaL-resistance protein WDLP6_RS06745 ENOG4105CAU Arsenical resistance protein, ArsH WDLP6_RS06750 ENOG4105CH2 amidohydrolase WDLP6_RS06755 ENOG4105EN6 Membrane WDLP6_RS06790 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving WDLP6_RS06795 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) WDLP6_RS06805 ENOG4105M6F mutator MutT protein WDLP6_RS06810 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) WDLP6_RS06825 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein WDLP6_RS06845 ENOG4107QHF type ii secretion system protein e WDLP6_RS06855 ENOG4108KMV Glycosyl transferase (Group 1 WDLP6_RS06875 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) WDLP6_RS06885 ENOG4105DZ1 carboxypeptidase WDLP6_RS06890 ENOG4105C6Y Udp-glucose 6-dehydrogenase WDLP6_RS06900 ENOG4106WTF Glycosyl transferase, family 2 WDLP6_RS06905 ENOG4105CH7 arginosuccinase WDLP6_RS06910 ENOG4108HRK Histidine kinase WDLP6_RS06915 ENOG4108NEV two component transcriptional regulator, LytTR family WDLP6_RS06920 ENOG4105DSF transport protein WDLP6_RS06930 ENOG4105CSH Transporter WDLP6_RS06965 ENOG4105H9W Short-chain dehydrogenase reductase Sdr WDLP6_RS06970 ENOG4105CPQ Dehydrogenase WDLP6_RS06980 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS06985 ENOG4105CNN ABC, transporter WDLP6_RS06990 ENOG4105C0Z ABC transporter WDLP6_RS06995 ENOG4108IV0 ABC, transporter WDLP6_RS07015 ENOG4105CXK mandelate racemase muconate lactonizing WDLP6_RS07030 ENOG4105HSS phospholipase C WDLP6_RS07035 ENOG4105BZ4 penicillin-binding protein WDLP6_RS07045 ENOG4105KA0 thioesterase Superfamily protein WDLP6_RS07060 ENOG4105EAH synthase WDLP6_RS07065 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) WDLP6_RS07070 ENOG4105K46 50S ribosomal protein l27 WDLP6_RS07075 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control WDLP6_RS07080 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) WDLP6_RS07090 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WDLP6_RS07095 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) WDLP6_RS07100 ENOG4105E4C Lytic transglycosylase catalytic WDLP6_RS07105 ENOG4105C37 (CBS) domain WDLP6_RS07110 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) WDLP6_RS07125 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) WDLP6_RS07130 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) WDLP6_RS07135 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) WDLP6_RS07145 ENOG4105EGS Mechanosensitive ion channel WDLP6_RS07150 ENOG4107T6V glycerophosphoryl diester phosphodiesterase WDLP6_RS07155 ENOG4108IJ9 (ABC) transporter WDLP6_RS07165 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component WDLP6_RS07175 ENOG4108JQ1 Dehydrogenase WDLP6_RS07195 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WDLP6_RS07210 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) WDLP6_RS07215 ENOG4108IA2 Sodium pantothenate symporter WDLP6_RS07230 ENOG4105C9M aspartyl-trna synthetase WDLP6_RS07235 ENOG4108TIT dATP pyrophosphohydrolase WDLP6_RS07245 ENOG4105EUJ GTP cyclohydrolase i WDLP6_RS07280 ENOG4106H29 UPF0391 membrane protein WDLP6_RS07285 ENOG4105BZU Histidine kinase WDLP6_RS07290 ENOG4105WH1 Two component transcriptional regulator luxr family WDLP6_RS07305 ENOG41066T0 asmA family WDLP6_RS07310 ENOG4105D06 uba thif-type nad fad binding protein WDLP6_RS07315 ENOG4105CN1 protease WDLP6_RS07320 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) WDLP6_RS07325 ENOG4105WZW rhodanese family WDLP6_RS07330 ENOG4105VW4 glutaredoxin 3 WDLP6_RS07335 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) WDLP6_RS07340 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase WDLP6_RS07345 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase WDLP6_RS07350 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) WDLP6_RS07360 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) WDLP6_RS07365 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) WDLP6_RS07370 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) WDLP6_RS07375 ENOG4108IYU L-aspartate oxidase WDLP6_RS07395 ENOG4105CHH sulfate transporter WDLP6_RS07405 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) WDLP6_RS07410 ENOG4108YXG UPF0502 protein WDLP6_RS07420 ENOG4107R11 Transcriptional regulator WDLP6_RS07445 ENOG4108IEG Formate dehydrogenase Alpha subunit WDLP6_RS07455 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) WDLP6_RS07495 ENOG4105QAX Iron-sulfur WDLP6_RS07515 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WDLP6_RS07525 ENOG4105CV6 ABC transporter, permease WDLP6_RS07535 ENOG4105C28 cystathionine WDLP6_RS07540 ENOG41069M3 Transcriptional regulator WDLP6_RS07545 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WDLP6_RS07550 ENOG4105CMT Dihydroxyacetone kinase WDLP6_RS07560 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit WDLP6_RS07565 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter WDLP6_RS07570 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS07575 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit WDLP6_RS07580 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) WDLP6_RS07585 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS07590 ENOG4105C0Z ABC transporter WDLP6_RS07595 ENOG4105CP9 extracellular ligand-binding receptor WDLP6_RS07600 ENOG4108IV0 ABC, transporter WDLP6_RS07605 ENOG4105CQB FAD linked oxidase domain protein WDLP6_RS07620 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) WDLP6_RS07625 ENOG4108RAC Rubrerythrin WDLP6_RS07650 ENOG4105W5Q DNA repair protein (RadC WDLP6_RS07655 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase WDLP6_RS07660 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) WDLP6_RS07665 ENOG4105C7B Threonine dehydratase WDLP6_RS07675 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) WDLP6_RS07685 ENOG4105DFP Integrase WDLP6_RS07975 ENOG4105KVH Transcriptional regulator WDLP6_RS07980 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS07985 ENOG4108M9J MaoC like domain protein WDLP6_RS07990 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS07995 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr WDLP6_RS08000 ENOG4105CYC Transferase WDLP6_RS08005 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS08020 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS08030 ENOG4105C0Z ABC transporter WDLP6_RS08035 ENOG4108IV0 ABC, transporter WDLP6_RS08040 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WDLP6_RS08060 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS08070 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WDLP6_RS08075 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) WDLP6_RS08080 ENOG4108IPT Naphthoate synthase WDLP6_RS08085 ENOG4108IV0 ABC, transporter WDLP6_RS08100 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS08110 ENOG4105BZJ Electron transfer flavoprotein WDLP6_RS08115 ENOG4105C10 Electron transfer flavoprotein WDLP6_RS08130 ENOG4105CHR reductase WDLP6_RS08135 ENOG4105CJW magnesium transporter WDLP6_RS08140 ENOG4105C7I Dehydrogenase WDLP6_RS08150 ENOG4105BZU Histidine kinase WDLP6_RS08160 ENOG4105C31 Tryptophanyl-tRNA synthetase WDLP6_RS08165 ENOG4108Z4T Peptidase M50 WDLP6_RS08170 ENOG4107RTD sua5 ycio yrdc ywlc family protein WDLP6_RS08180 ENOG4105DB7 PHP domain protein WDLP6_RS08185 ENOG4105CSR polyphosphate kinase 2 WDLP6_RS08195 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein WDLP6_RS08200 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS08210 ENOG4105C2J ABC transporter WDLP6_RS08215 ENOG4108IV0 ABC, transporter WDLP6_RS08230 ENOG41079KZ Major Facilitator Superfamily WDLP6_RS08235 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) WDLP6_RS08240 ENOG4108Z6B deaminase WDLP6_RS08275 ENOG4105EYW Ion transport protein WDLP6_RS08310 ENOG4105BZU Histidine kinase WDLP6_RS08315 ENOG4105E6M Sulphatase-modifying factor protein WDLP6_RS08320 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WDLP6_RS08330 ENOG4107SCA Formamidase (EC 3.5.1.49) WDLP6_RS08355 ENOG4107UXM Membrane WDLP6_RS08370 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WDLP6_RS08375 ENOG4105D7T ABC transporter WDLP6_RS08385 ENOG4105C6K Malic enzyme WDLP6_RS08395 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS08400 ENOG4106P55 Transcriptional regulator WDLP6_RS08410 ENOG4105CYM Glutathione S-transferase WDLP6_RS08415 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS08425 ENOG4105DC8 reductase WDLP6_RS08445 ENOG4105CJ2 (LipO)protein WDLP6_RS08450 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WDLP6_RS08460 ENOG4107E2E PKHD-type hydroxylase WDLP6_RS08495 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) WDLP6_RS08525 ENOG4108YYH Nadph-dependent fmn reductase WDLP6_RS08545 ENOG4105ETE Transcriptional regulator (LacI family WDLP6_RS08555 ENOG4105RE0 Asp Glu hydantoin racemase WDLP6_RS08575 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase WDLP6_RS08590 ENOG4108IG5 Transcriptional regulator WDLP6_RS08595 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) WDLP6_RS08600 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS08610 ENOG4108ERU trap dicarboxylate transporter subunit DctP WDLP6_RS08675 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS08680 ENOG4105FDP GntR family transcriptional regulator WDLP6_RS08690 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS08695 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS08700 ENOG4105C7F AcnD-accessory protein PrpF WDLP6_RS08730 ENOG4105EAM Na Pi-cotransporter WDLP6_RS08745 ENOG4105ETT transcriptional Regulator, LysR family WDLP6_RS08785 ENOG4105C3U ABC transporter WDLP6_RS08810 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WDLP6_RS08820 ENOG4106FTQ Taurine ABC transporter, periplasmic WDLP6_RS08830 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WDLP6_RS08835 ENOG4105CYM Glutathione S-transferase WDLP6_RS08860 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) WDLP6_RS08865 ENOG4108FUF Transcriptional regulator, IclR family WDLP6_RS08890 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS08895 ENOG4105CD5 CoA-binding domain protein WDLP6_RS08915 ENOG4105HEI LysR family (Transcriptional regulator WDLP6_RS08925 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS08930 ENOG4108EKI Dehydrogenase WDLP6_RS08940 ENOG4108FUF Transcriptional regulator, IclR family WDLP6_RS09010 ENOG4105WH1 Two component transcriptional regulator luxr family WDLP6_RS09015 ENOG4105ENE Histidine kinase WDLP6_RS09035 ENOG4108FUF Transcriptional regulator, IclR family WDLP6_RS09050 ENOG4105DUM transcriptional regulator, lysR family WDLP6_RS09055 ENOG4105DB1 molybdopterin oxidoreductase WDLP6_RS09060 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein WDLP6_RS09065 ENOG4108KDI dmso reductase anchor subunit WDLP6_RS09085 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WDLP6_RS09110 ENOG4105C3M thioredoxin reductase WDLP6_RS09135 ENOG4105CDA abc transporter atp-binding protein WDLP6_RS09195 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) WDLP6_RS09200 ENOG4108ZC9 flagellar basal-body rod protein flgc WDLP6_RS09205 ENOG4105W00 Flagellar hook capping protein WDLP6_RS09210 ENOG4105BZE flagellar hook protein, FlgE WDLP6_RS09215 ENOG4108KPB Flagellar basal-body rod protein FlgF WDLP6_RS09220 ENOG4105CGA flagellar basal-body rod protein FlgG WDLP6_RS09235 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj WDLP6_RS09240 ENOG4105C8Q Methyl-accepting chemotaxis WDLP6_RS09245 ENOG4108V3W Chemotaxis protein, CheW WDLP6_RS09250 ENOG4105C8Q Methyl-accepting chemotaxis WDLP6_RS09255 ENOG4105C8Q Methyl-accepting chemotaxis WDLP6_RS09260 ENOG4105C8Q Methyl-accepting chemotaxis WDLP6_RS09265 ENOG4105C8Q Methyl-accepting chemotaxis WDLP6_RS09270 ENOG4105E1Q flagellar hook-associated protein WDLP6_RS09275 ENOG4105DTJ flagellar hook-associated protein WDLP6_RS09290 ENOG4108SVW integral membrane protein WDLP6_RS09295 ENOG4106HB6 Alpha beta hydrolase WDLP6_RS09335 ENOG4105E0F Histidine kinase WDLP6_RS09370 ENOG4105D19 Role in flagellar biosynthesis (By similarity) WDLP6_RS09375 ENOG4105VS8 Flagellar biosynthetic protein fliq WDLP6_RS09380 ENOG4105CN7 Flagellar biosynthetic protein FliP WDLP6_RS09390 ENOG4105DD5 Flagellar motor switch protein WDLP6_RS09395 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WDLP6_RS09400 ENOG4107ZI8 flagellar basal body-associated protein flil WDLP6_RS09405 ENOG4105WF4 Flagellar hook-length control protein WDLP6_RS09410 ENOG4105GSA Flagellar export protein flij WDLP6_RS09415 ENOG4108JIR Flagellum-specific ATP synthase WDLP6_RS09425 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WDLP6_RS09430 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) WDLP6_RS09445 ENOG4105DTS flagellar hook-associated WDLP6_RS09450 ENOG4105MQ3 flagellar protein FliS WDLP6_RS09465 ENOG4105D00 flagellar biosynthetic protein flhB WDLP6_RS09475 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region WDLP6_RS09480 ENOG4107RD7 Flagellar Motor Protein, MotA WDLP6_RS09485 ENOG4105ER2 Ompa motb domain protein WDLP6_RS09490 ENOG4105CBS Chea signal transduction histidine kinase WDLP6_RS09495 ENOG4105D58 Diguanylate phosphodiesterase WDLP6_RS09500 ENOG4105BZU Histidine kinase WDLP6_RS09515 ENOG4108VYJ response regulator receiver protein WDLP6_RS09520 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) WDLP6_RS09535 ENOG4105D00 flagellar biosynthetic protein flhB WDLP6_RS09540 ENOG4105D7B Flagellar biosynthesis protein flha WDLP6_RS09545 ENOG4105FZW flagellar biosynthesis regulator FlhF WDLP6_RS09555 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WDLP6_RS09570 ENOG4105TV9 FHA Domain-Containing protein WDLP6_RS09580 ENOG4105BZU Histidine kinase WDLP6_RS09595 ENOG4106IJN integrase catalytic domain-containing protein WDLP6_RS09740 ENOG4105EMN RNA polymerase sigma factor WDLP6_RS09800 ENOG4105BZU Histidine kinase WDLP6_RS09805 ENOG4105C01 Dihydroxy-acid dehydratase WDLP6_RS09830 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) WDLP6_RS09835 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) WDLP6_RS09845 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS09870 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 WDLP6_RS09875 ENOG4105CD8 aminopeptidase N WDLP6_RS09890 ENOG4105CPC Aldo Keto reductase WDLP6_RS09895 ENOG4108Z66 YbaK ebsC protein WDLP6_RS09900 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) WDLP6_RS09905 ENOG4105M4H endoribonuclease L-psp WDLP6_RS09915 ENOG4108VPT UPF0234 protein WDLP6_RS09920 ENOG4105D4A Cell wall formation (By similarity) WDLP6_RS09925 ENOG4105CDH Citrulline--aspartate ligase WDLP6_RS09930 ENOG4105NBK UPF0345 protein WDLP6_RS09940 ENOG4105KUZ arsenate reductase WDLP6_RS09945 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase WDLP6_RS09960 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase WDLP6_RS09965 ENOG4105C28 cystathionine WDLP6_RS09970 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) WDLP6_RS10000 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS10005 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS10020 ENOG4105E1F short-chain dehydrogenase reductase WDLP6_RS10025 ENOG4105CF7 AraC family transcriptional regulator WDLP6_RS10040 ENOG4105ETT transcriptional Regulator, LysR family WDLP6_RS10045 ENOG410846T CoA-transferase family III WDLP6_RS10050 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS10065 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) WDLP6_RS10070 ENOG4105EM7 Selenocysteine-specific translation elongation factor WDLP6_RS10075 ENOG4105C3M thioredoxin reductase WDLP6_RS10105 ENOG4105H9W Short-chain dehydrogenase reductase Sdr WDLP6_RS10110 ENOG41061TZ Short-chain dehydrogenase reductase Sdr WDLP6_RS10115 ENOG4107EFR Flavocytochrome c WDLP6_RS10120 ENOG4105CHR reductase WDLP6_RS10135 ENOG4107EFR Flavocytochrome c WDLP6_RS10150 ENOG41083Z3 extracellular ligand-binding receptor WDLP6_RS10165 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS10170 ENOG4105CF8 branched-chain amino acid ABC transporter, permease WDLP6_RS10175 ENOG4105C0Z ABC transporter WDLP6_RS10180 ENOG4108IV0 ABC, transporter WDLP6_RS10195 ENOG4105HEI LysR family (Transcriptional regulator WDLP6_RS10200 ENOG4105C10 Electron transfer flavoprotein WDLP6_RS10205 ENOG4105BZJ Electron transfer flavoprotein WDLP6_RS10210 ENOG4105C3M thioredoxin reductase WDLP6_RS10225 ENOG4105C7W Xanthine dehydrogenase WDLP6_RS10235 ENOG4105C7N Xanthine uracil vitamin C permease WDLP6_RS10240 ENOG4108JQ9 ABC transporter WDLP6_RS10245 ENOG4105UIB (ABC) transporter WDLP6_RS10260 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WDLP6_RS10270 ENOG4105BZU Histidine kinase WDLP6_RS10275 ENOG4107QHF type ii secretion system protein e WDLP6_RS10280 ENOG4105BZU Histidine kinase WDLP6_RS10295 ENOG4108TJN glycosyl transferase group 1 WDLP6_RS10300 ENOG4107QUY Guanine deaminase WDLP6_RS10305 ENOG4105DHP deoxycytidine triphosphate deaminase WDLP6_RS10310 ENOG4105CGZ zinc metallopeptidase WDLP6_RS10315 ENOG4105C1J atp-dependent rna helicase WDLP6_RS10320 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) WDLP6_RS10325 ENOG4105EE5 Membrane protein terC WDLP6_RS10345 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WDLP6_RS10350 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) WDLP6_RS10355 ENOG41060W2 glyoxylate carboligase WDLP6_RS10360 ENOG4105CC0 LysR family Transcriptional regulator WDLP6_RS10375 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) WDLP6_RS10380 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) WDLP6_RS10385 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) WDLP6_RS10390 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WDLP6_RS10395 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) WDLP6_RS10400 ENOG4108VQN 4-hydroxyphenylacetate 3-monooxygenase reductase WDLP6_RS10405 ENOG4108R86 Transcriptional regulator WDLP6_RS10415 ENOG4107RUE extracellular solute-binding protein family 1 WDLP6_RS10420 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WDLP6_RS10425 ENOG4105F38 ABC transporter, permease WDLP6_RS10430 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component WDLP6_RS10440 ENOG4107YCY Transcriptional regulator WDLP6_RS10445 ENOG4105CK2 sodium dicarboxylate symporter WDLP6_RS10460 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) WDLP6_RS10470 ENOG4105DQ4 alcohol dehydrogenase WDLP6_RS10505 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WDLP6_RS10515 ENOG4107YNJ LysR family Transcriptional regulator WDLP6_RS10530 ENOG4108Z40 Transcriptional regulator WDLP6_RS10545 ENOG4108M9J MaoC like domain protein WDLP6_RS10550 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS10580 ENOG4105JSC dimethylmenaquinone methyltransferase WDLP6_RS10590 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WDLP6_RS10595 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr WDLP6_RS10615 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WDLP6_RS10620 ENOG4105W8H transhydrogenase (subunit alpha WDLP6_RS10625 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WDLP6_RS10630 ENOG4108R85 Short chain dehydrogenase WDLP6_RS10640 ENOG4108JGH Tetr family transcriptional regulator WDLP6_RS10645 ENOG4105CHR reductase WDLP6_RS10665 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WDLP6_RS10680 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein WDLP6_RS10685 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein WDLP6_RS10715 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS10735 ENOG4105DZS Phenylacetate-CoA ligase WDLP6_RS10760 ENOG4105C0Z ABC transporter WDLP6_RS10765 ENOG4108IV0 ABC, transporter WDLP6_RS10770 ENOG4105CQB FAD linked oxidase domain protein WDLP6_RS10775 ENOG4108YXU transcriptional regulator AsnC family WDLP6_RS10795 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WDLP6_RS10815 ENOG4105DZG Dehydrogenase WDLP6_RS10840 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS10860 ENOG4105CJ1 ABC, transporter WDLP6_RS10865 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E WDLP6_RS10875 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) WDLP6_RS10880 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) WDLP6_RS10900 ENOG4105EAB amino acid AbC transporter WDLP6_RS10910 ENOG4105C26 Dehydrogenase WDLP6_RS10915 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS10935 ENOG4107XCH Cyclase family WDLP6_RS10945 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS10995 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) WDLP6_RS11000 ENOG4105EA8 2-Nitropropane dioxygenase WDLP6_RS11010 ENOG4105HF0 Membrane WDLP6_RS11030 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS11040 ENOG4105EGI Transcriptional regulator WDLP6_RS11050 ENOG4108ERU trap dicarboxylate transporter subunit DctP WDLP6_RS11060 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS11065 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS11115 ENOG4105EQ2 LysR family Transcriptional regulator WDLP6_RS11120 ENOG4107S5I aldo keto reductase WDLP6_RS11130 ENOG4105CQB FAD linked oxidase domain protein WDLP6_RS11135 ENOG4105CBG Sulfatase WDLP6_RS11140 ENOG4106NZI LysR family Transcriptional regulator WDLP6_RS11160 ENOG4105CMJ mandelate racemase muconate lactonizing WDLP6_RS11165 ENOG4107YNJ LysR family Transcriptional regulator WDLP6_RS11190 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr WDLP6_RS11195 ENOG4105CC9 acyl-Coa dehydrogenase WDLP6_RS11200 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS11210 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS11225 ENOG4105RQF LysR family Transcriptional regulator WDLP6_RS11245 ENOG4105C5I Dehydrogenase WDLP6_RS11270 ENOG4105ETT transcriptional Regulator, LysR family WDLP6_RS11275 ENOG4105KME endoribonuclease L-psp WDLP6_RS11305 ENOG4105F38 ABC transporter, permease WDLP6_RS11340 ENOG4105CQZ Histidine kinase WDLP6_RS11385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WDLP6_RS11395 ENOG4105C08 Histidine kinase WDLP6_RS11400 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WDLP6_RS11430 ENOG4105C7W Xanthine dehydrogenase WDLP6_RS11435 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding WDLP6_RS11440 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit WDLP6_RS11445 ENOG4105ECQ AraC Family Transcriptional Regulator WDLP6_RS11450 ENOG4108SUT Major Facilitator Superfamily WDLP6_RS11455 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) WDLP6_RS11460 ENOG4105CV8 reductase WDLP6_RS11465 ENOG4105C2W permease WDLP6_RS11495 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein WDLP6_RS11500 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) WDLP6_RS11515 ENOG4107YCY Transcriptional regulator WDLP6_RS11545 ENOG410810E transcriptional regulator, lysR family WDLP6_RS11550 ENOG4105CI0 Citrate lyase WDLP6_RS11560 ENOG4105GAK amidohydrolase 2 WDLP6_RS11570 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS11585 ENOG4105CJ1 ABC, transporter WDLP6_RS11590 ENOG4107QWP ABC-2 type transporter WDLP6_RS11595 ENOG4107QWP ABC-2 type transporter WDLP6_RS11625 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein WDLP6_RS11640 ENOG4105F4K antigen 43 WDLP6_RS11690 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS11695 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase WDLP6_RS11700 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase WDLP6_RS11715 ENOG4105R0I Feruloyl esterase WDLP6_RS11820 ENOG4105CDV Ompa motb domain protein WDLP6_RS11870 ENOG4105EMN RNA polymerase sigma factor WDLP6_RS11875 ENOG4108K2P TRANSCRIPTIONal WDLP6_RS11895 ENOG4108UKI Enoyl-CoA hydratase WDLP6_RS11905 ENOG4105D5K Hemolysin activator protein WDLP6_RS11910 ENOG4105CKT filamentous hemagglutinin WDLP6_RS11935 ENOG4105C59 p-type ATPase WDLP6_RS11945 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding WDLP6_RS11960 ENOG4107RT3 EamA-like transporter family WDLP6_RS11965 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WDLP6_RS11975 ENOG4107QKV phosphomannomutase WDLP6_RS11980 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase WDLP6_RS12015 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) WDLP6_RS12030 ENOG4105YA8 Transcriptional regulator WDLP6_RS12035 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) WDLP6_RS12050 ENOG4105CFH Aspartokinase WDLP6_RS12055 ENOG4105CPC Aldo Keto reductase WDLP6_RS12065 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) WDLP6_RS12090 ENOG4105C01 Dihydroxy-acid dehydratase WDLP6_RS12095 ENOG4108UHU Aldolase WDLP6_RS12105 ENOG4108UYE Lactoylglutathione lyase WDLP6_RS12120 ENOG4107RCV ABC transporter, permease WDLP6_RS12130 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS12135 ENOG4105EA8 2-Nitropropane dioxygenase WDLP6_RS12140 ENOG4107GJV short-chain dehydrogenase reductase WDLP6_RS12150 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS12155 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS12190 ENOG4105EMU Dehydrogenase WDLP6_RS12200 ENOG4108RTU Aldolase WDLP6_RS12210 ENOG4105C01 Dihydroxy-acid dehydratase WDLP6_RS12215 ENOG4107EJG GntR family transcriptional regulator WDLP6_RS12225 ENOG4105D56 permease protein WDLP6_RS12250 ENOG4105C1J atp-dependent rna helicase WDLP6_RS12260 ENOG4105C5H ABC transporter WDLP6_RS12270 ENOG4105BZ1 (ABC) transporter WDLP6_RS12280 ENOG4105KXX peptidase s58 dmpa WDLP6_RS12295 ENOG4107VXM glycerophosphoryl diester phosphodiesterase WDLP6_RS12310 ENOG4105E5Q amino acid AbC transporter WDLP6_RS12315 ENOG4105DRP amino acid AbC transporter WDLP6_RS12320 ENOG4107RP9 extracellular solute-binding protein, family 3 WDLP6_RS12330 ENOG4108Z9K Osmotically inducible protein WDLP6_RS12335 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS12345 ENOG4108R6G acetyltransferase WDLP6_RS12350 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase WDLP6_RS12355 ENOG4105CEP NADH dehydrogenase WDLP6_RS12365 ENOG41067HS methyltransferase WDLP6_RS12380 ENOG41081QV Universal stress protein WDLP6_RS12385 ENOG4105D3G Pseudouridine synthase WDLP6_RS12405 ENOG4105CKW Inner membrane protein yedI WDLP6_RS12410 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) WDLP6_RS12420 ENOG4105F4K antigen 43 WDLP6_RS12435 ENOG4106CJB Phospholipase Carboxylesterase WDLP6_RS12440 ENOG4105D9M gamma-glutamylcysteine synthetase WDLP6_RS12445 ENOG4107QWB Ornithine cyclodeaminase WDLP6_RS12450 ENOG4108UYB regulatoR WDLP6_RS12460 ENOG4105DY9 regulatoR WDLP6_RS12465 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) WDLP6_RS12490 ENOG4105E2B Taurine dioxygenase WDLP6_RS12495 ENOG4107RQ0 Maleylacetate reductase WDLP6_RS12505 ENOG4105GZI Transcriptional regulator WDLP6_RS12510 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS12515 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme WDLP6_RS12520 ENOG4105ERH Fumarylacetoacetate hydrolase WDLP6_RS12525 ENOG4105EA8 2-Nitropropane dioxygenase WDLP6_RS12555 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS12560 ENOG4105V9V Short-chain dehydrogenase reductase Sdr WDLP6_RS12565 ENOG4107XZC Restriction modification system DNA (Specificity WDLP6_RS12580 ENOG4105CX6 glutaminyL-tRNA synthetase WDLP6_RS12590 ENOG4108VAC response regulator WDLP6_RS12595 ENOG4108HRK Histidine kinase WDLP6_RS12615 ENOG4105BZS acriflavin resistance protein WDLP6_RS12620 ENOG4105BZS acriflavin resistance protein WDLP6_RS12625 ENOG4105ENJ RND efflux system, outer membrane lipoprotein WDLP6_RS12635 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WDLP6_RS12660 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) WDLP6_RS12670 ENOG4105ENH Sulfatase WDLP6_RS12675 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS12705 ENOG4105ECY inositol monophosphatase WDLP6_RS12715 ENOG4105D7W serine acetyltransferase WDLP6_RS12720 ENOG4108RIR Molybdenum cofactor biosynthesis protein WDLP6_RS12730 ENOG4105CMS peptidase U62, modulator of DNA gyrase WDLP6_RS12740 ENOG4105VCC 30S ribosomal protein S21 WDLP6_RS12745 ENOG4105CBX hi0933 family WDLP6_RS12755 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WDLP6_RS12760 ENOG4108MTB glycosyl transferase family WDLP6_RS12775 ENOG4108IFG nitrite reductase, (NAD(P)H) WDLP6_RS12780 ENOG4105D9P serine threonine protein kinase WDLP6_RS12795 ENOG4105D7T ABC transporter WDLP6_RS12805 ENOG4105I5W Transporter WDLP6_RS12815 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WDLP6_RS12825 ENOG4107Y70 Heat shock protein WDLP6_RS12830 ENOG4105ES9 amino acid WDLP6_RS12840 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) WDLP6_RS12845 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) WDLP6_RS12855 ENOG4105CP7 Triose-phosphate isomerase WDLP6_RS12860 ENOG4107EJC Preprotein translocase subunit SecG WDLP6_RS12870 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain WDLP6_RS12875 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WDLP6_RS12880 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain WDLP6_RS12885 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WDLP6_RS12895 ENOG4107QIZ NADH dehydrogenase WDLP6_RS12900 ENOG4108IEH NADH dehydrogenase subunit g WDLP6_RS12905 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) WDLP6_RS12910 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WDLP6_RS12915 ENOG4105DF2 NADH dehydrogenase subunit j WDLP6_RS12920 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WDLP6_RS12930 ENOG4105C8S subunit m WDLP6_RS12935 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WDLP6_RS12945 ENOG4108YZ4 nudix hydrolase WDLP6_RS12955 ENOG4105BZ1 (ABC) transporter WDLP6_RS12960 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes WDLP6_RS12970 ENOG4105CW7 secretion protein, HlyD family WDLP6_RS12975 ENOG4105C0R drug resistance transporter emrb qaca subfamily WDLP6_RS12980 ENOG4105C0Z ABC transporter WDLP6_RS12985 ENOG4108IV0 ABC, transporter WDLP6_RS13000 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS13025 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WDLP6_RS13035 ENOG4105CSH Transporter WDLP6_RS13045 ENOG4108SHN Glycosyl transferase, family 2 WDLP6_RS13075 ENOG4105GRZ Ycii-related protein WDLP6_RS13080 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WDLP6_RS13095 ENOG4105JXH GntR family transcriptional regulator WDLP6_RS13110 ENOG410846T CoA-transferase family III WDLP6_RS13115 ENOG4105EXG Transcriptional regulator WDLP6_RS13125 ENOG4105CG3 alpha amylase, catalytic region WDLP6_RS13130 ENOG4107QK4 glycoside hydrolase, family 3 domain protein WDLP6_RS13145 ENOG4105CQ0 ABC transporter WDLP6_RS13155 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WDLP6_RS13160 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) WDLP6_RS13170 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate WDLP6_RS13180 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS13185 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit WDLP6_RS13190 ENOG4105ETE Transcriptional regulator (LacI family WDLP6_RS13200 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) WDLP6_RS13205 ENOG4105DQR SNARE associated Golgi WDLP6_RS13220 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WDLP6_RS13225 ENOG4105K8N protein family UPF0079, ATPase WDLP6_RS13230 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) WDLP6_RS13250 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WDLP6_RS13265 ENOG4105ED9 Protein of unknown function (DUF455) WDLP6_RS13270 ENOG4108Z0R Transferase WDLP6_RS13275 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) WDLP6_RS13285 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) WDLP6_RS13295 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) WDLP6_RS13300 ENOG4105CKK Glycosyl transferase, family 2 WDLP6_RS13305 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WDLP6_RS13310 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) WDLP6_RS13315 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) WDLP6_RS13320 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) WDLP6_RS13325 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) WDLP6_RS13330 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WDLP6_RS13335 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) WDLP6_RS13340 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase WDLP6_RS13350 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) WDLP6_RS13360 ENOG4108YZY peptidylprolyl cis-trans isomerase WDLP6_RS13365 ENOG4105EZE Cupin 4 family protein WDLP6_RS13380 ENOG4105Q2H domain protein WDLP6_RS13385 ENOG4105GJM (LipO)protein WDLP6_RS13390 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WDLP6_RS13405 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WDLP6_RS13415 ENOG4105EMN RNA polymerase sigma factor WDLP6_RS13420 ENOG4105E4C Lytic transglycosylase catalytic WDLP6_RS13425 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WDLP6_RS13450 ENOG4105DRP amino acid AbC transporter WDLP6_RS13455 ENOG4105E5Q amino acid AbC transporter WDLP6_RS13460 ENOG4105EAB amino acid AbC transporter WDLP6_RS13465 ENOG4105CDA abc transporter atp-binding protein WDLP6_RS13475 ENOG4105D7K pfkb domain protein WDLP6_RS13485 ENOG4108M60 Transcriptional regulator WDLP6_RS13495 ENOG4105C26 Dehydrogenase WDLP6_RS13500 ENOG4107RTG Major Facilitator superfamily WDLP6_RS13505 ENOG4108UYU AsnC family transcriptional regulator WDLP6_RS13530 ENOG4108EC8 DNA internalization-related competence protein ComEC WDLP6_RS13545 ENOG4108JJA ABC, transporter WDLP6_RS13550 ENOG4105C42 Type I secretion membrane fusion protein (HlyD WDLP6_RS13585 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) WDLP6_RS13590 ENOG4105E98 transcriptional regulator DeoR family WDLP6_RS13595 ENOG4105C6V Glycerol-3-phosphate dehydrogenase WDLP6_RS13600 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WDLP6_RS13605 ENOG4108IJ9 (ABC) transporter WDLP6_RS13615 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component WDLP6_RS13635 ENOG4105CVE Lytic murein transglycosylase WDLP6_RS13640 ENOG4105F8C transglutaminase domain-containing protein WDLP6_RS13650 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WDLP6_RS13655 ENOG4105DGU Histone deacetylase WDLP6_RS13660 ENOG4105EGS Mechanosensitive ion channel WDLP6_RS13665 ENOG4105BZJ Electron transfer flavoprotein WDLP6_RS13670 ENOG4105C10 Electron transfer flavoprotein WDLP6_RS13675 ENOG4105CSU acyl-Coa dehydrogenase WDLP6_RS13705 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WDLP6_RS13710 ENOG4105C4M (Ubiquinol oxidase) subunit I WDLP6_RS13720 ENOG4105BZU Histidine kinase WDLP6_RS13740 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase WDLP6_RS13755 ENOG4105VN1 Heat shock protein WDLP6_RS13760 ENOG4105CSH Transporter WDLP6_RS13775 ENOG4105IQ5 FAD linked oxidase domain protein WDLP6_RS13785 ENOG4107HP6 Transcriptional regulator WDLP6_RS13790 ENOG4105E2X shikimate dehydrogenase WDLP6_RS13800 ENOG4105E2X shikimate dehydrogenase WDLP6_RS13805 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase WDLP6_RS13840 ENOG4105EGI Transcriptional regulator WDLP6_RS13845 ENOG4105CBP Major Facilitator WDLP6_RS13860 ENOG4105CHP RNA polymerase WDLP6_RS13870 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) WDLP6_RS13880 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor WDLP6_RS13885 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) WDLP6_RS13890 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) WDLP6_RS13900 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS13910 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit WDLP6_RS13915 ENOG4105EXW epimerase dehydratase WDLP6_RS13920 ENOG4105BZU Histidine kinase WDLP6_RS13925 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase WDLP6_RS13930 ENOG4105CHR reductase WDLP6_RS13945 ENOG4105DHQ Histidine kinase WDLP6_RS13950 ENOG4105XJC Two component transcriptional regulator (Winged helix family WDLP6_RS13960 ENOG4105DIJ Phosphoethanolamine transferase WDLP6_RS13975 ENOG4107FQ9 ethanolamine ammonia-lyase WDLP6_RS13980 ENOG4105CPD ethanolamine ammonia-lyase WDLP6_RS13985 ENOG4108V1T peptidylprolyl cis-trans isomerase WDLP6_RS13995 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WDLP6_RS14005 ENOG4105CF1 Alkylated DNA repair protein WDLP6_RS14035 ENOG4108KX4 response regulator WDLP6_RS14070 ENOG4105C26 Dehydrogenase WDLP6_RS14080 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS14085 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WDLP6_RS14090 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WDLP6_RS14125 ENOG4106S2D Transcriptional regulator WDLP6_RS14130 ENOG4105WH1 Two component transcriptional regulator luxr family WDLP6_RS14145 ENOG4107RZC phospholipase d WDLP6_RS14155 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) WDLP6_RS14165 ENOG4105BZ1 (ABC) transporter WDLP6_RS14170 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b WDLP6_RS14195 ENOG4105C0B DNA polymerase III (alpha subunit) WDLP6_RS14215 ENOG4108W9H Tetr family transcriptional regulator WDLP6_RS14235 ENOG4105BZ9 Cytochrome C oxidase, subunit I WDLP6_RS14240 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) WDLP6_RS14255 ENOG4105NXH GreA GreB family elongation factor WDLP6_RS14270 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit WDLP6_RS14275 ENOG4108ERU trap dicarboxylate transporter subunit DctP WDLP6_RS14290 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS14295 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr WDLP6_RS14305 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha WDLP6_RS14310 ENOG4105CMV Succinyl-CoA synthetase subunit beta WDLP6_RS14315 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS14330 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS14335 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein WDLP6_RS14340 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS14385 ENOG4105CHR reductase WDLP6_RS14395 ENOG4108U78 Glutathione S-transferase WDLP6_RS14455 ENOG4105EYH Exonuclease WDLP6_RS14465 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) WDLP6_RS14490 ENOG4105C2M dna polymerase I WDLP6_RS15055 ENOG4105D82 Glutamate dehydrogenase WDLP6_RS15065 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WDLP6_RS15075 ENOG4105MWK D-amino acid dehydrogenase, small subunit WDLP6_RS15110 ENOG4108MUZ hydrolase WDLP6_RS15115 ENOG4107HP6 Transcriptional regulator WDLP6_RS15120 ENOG4105CHR reductase WDLP6_RS15125 ENOG4105C7K acetolactate synthase WDLP6_RS15130 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) WDLP6_RS15150 ENOG4105MSY salicylate hydroxylase WDLP6_RS15170 ENOG4108Z9W Outer membrane porin WDLP6_RS15180 ENOG4106NZI LysR family Transcriptional regulator WDLP6_RS15185 ENOG4105E2B Taurine dioxygenase WDLP6_RS15195 ENOG4105C26 Dehydrogenase WDLP6_RS15210 ENOG4105MP9 class II Aldolase WDLP6_RS15240 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i WDLP6_RS15280 ENOG4105DS0 Transcriptional regulator, Crp Fnr family WDLP6_RS15300 ENOG4105F8V Hydrolase, tatD family WDLP6_RS15310 ENOG4107QRG dna polymerase iii WDLP6_RS15315 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) WDLP6_RS15320 ENOG4105HHA aminodeoxychorismate lyase WDLP6_RS15325 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) WDLP6_RS15330 ENOG4105VCD cytoplasmic protein WDLP6_RS15335 ENOG4105D22 carbon starvation protein WDLP6_RS15370 ENOG4105ETT transcriptional Regulator, LysR family WDLP6_RS15390 ENOG4105BZM domain protein WDLP6_RS15395 ENOG4105EJC lysr family transcriptional regulator WDLP6_RS15420 ENOG4107QJQ Mate efflux family protein WDLP6_RS15465 ENOG4105C0R drug resistance transporter emrb qaca subfamily WDLP6_RS15470 ENOG4105C2C drug resistance transporter, Bcr CflA WDLP6_RS15485 ENOG4105DY2 Paraquat-inducible protein b WDLP6_RS15490 ENOG4105F1S paraquat-inducible protein a WDLP6_RS15495 ENOG4105F1S paraquat-inducible protein a WDLP6_RS15500 ENOG4105HEI LysR family (Transcriptional regulator WDLP6_RS15505 ENOG4105F27 Major Facilitator WDLP6_RS15510 ENOG4105CPC Aldo Keto reductase WDLP6_RS15515 ENOG4105XJC Two component transcriptional regulator (Winged helix family WDLP6_RS15520 ENOG4105DHQ Histidine kinase WDLP6_RS15530 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) WDLP6_RS15535 ENOG4105ETT transcriptional Regulator, LysR family WDLP6_RS15540 ENOG4105KCV RNA signal recognition particle 4.5S RNA WDLP6_RS15560 ENOG4105CSU acyl-Coa dehydrogenase WDLP6_RS15565 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein WDLP6_RS15575 ENOG4105CHR reductase WDLP6_RS15585 ENOG4105CSU acyl-Coa dehydrogenase WDLP6_RS15590 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS15595 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) WDLP6_RS15600 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WDLP6_RS15605 ENOG4108IV0 ABC, transporter WDLP6_RS15610 ENOG4105C0Z ABC transporter WDLP6_RS15620 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS15630 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS15635 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) WDLP6_RS15640 ENOG4105CNG UPF0061 protein WDLP6_RS15645 ENOG4105E0X reductase WDLP6_RS15650 ENOG4107835 probably involved in intracellular septation (By similarity) WDLP6_RS15660 ENOG4107TF3 peptidylprolyl cis-trans isomerase WDLP6_RS15665 ENOG4108ETH Formylglycinamide ribotide synthetase WDLP6_RS15670 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WDLP6_RS15675 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) WDLP6_RS15680 ENOG4105MGM doxx family WDLP6_RS15685 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WDLP6_RS15695 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) WDLP6_RS15705 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) WDLP6_RS15745 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) WDLP6_RS15750 ENOG4108IJ6 ABC transporter WDLP6_RS15755 ENOG4105ECW sulfate abc transporter WDLP6_RS15760 ENOG4108I5D sulfate abc transporter WDLP6_RS15765 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein WDLP6_RS15775 ENOG4105JQN Transcriptional regulator WDLP6_RS15780 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) WDLP6_RS15790 ENOG4105D7W serine acetyltransferase WDLP6_RS15795 ENOG4106NZI LysR family Transcriptional regulator WDLP6_RS15810 ENOG4105DG4 malate L-lactate dehydrogenase WDLP6_RS15820 ENOG4108UZX fmn reductase WDLP6_RS15825 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein WDLP6_RS15830 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) WDLP6_RS15835 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) WDLP6_RS15845 ENOG4108UT2 hemolysin iii WDLP6_RS15855 ENOG4107QNK )-transporter WDLP6_RS15870 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) WDLP6_RS15880 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) WDLP6_RS15885 ENOG4108Z4U Ferredoxin WDLP6_RS15890 ENOG4105CAY ferredoxin--nadp reductase WDLP6_RS15895 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase WDLP6_RS15905 ENOG4105W2Z cytochrome C, class I WDLP6_RS15915 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WDLP6_RS15920 ENOG4108TEB UPF0114 protein WDLP6_RS15970 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) WDLP6_RS15975 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) WDLP6_RS15980 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WDLP6_RS15985 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation WDLP6_RS16000 ENOG4105ENT Efflux transporter rnd family, mfp subunit WDLP6_RS16025 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant WDLP6_RS16030 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) WDLP6_RS16055 ENOG4108IV0 ABC, transporter WDLP6_RS16070 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WDLP6_RS16110 ENOG4105CHR reductase WDLP6_RS16130 ENOG4105CC0 LysR family Transcriptional regulator WDLP6_RS16140 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS16150 ENOG4105CC9 acyl-Coa dehydrogenase WDLP6_RS16160 ENOG4105CHR reductase WDLP6_RS16180 ENOG4107SFQ iron-sulfur binding WDLP6_RS16215 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) WDLP6_RS16240 ENOG4105DS0 Transcriptional regulator, Crp Fnr family WDLP6_RS16270 ENOG4105DHQ Histidine kinase WDLP6_RS16275 ENOG4105VEJ Heat shock protein WDLP6_RS16280 ENOG4105CSR polyphosphate kinase 2 WDLP6_RS16290 ENOG41069M3 Transcriptional regulator WDLP6_RS16315 ENOG4105CFH Aspartokinase WDLP6_RS16320 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) WDLP6_RS16325 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) WDLP6_RS16335 ENOG4105C8N cysteinyl-tRNA synthetase WDLP6_RS16355 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) WDLP6_RS16360 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) WDLP6_RS16375 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division WDLP6_RS16380 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) WDLP6_RS16385 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) WDLP6_RS16395 ENOG4105CWU Biogenesis protein WDLP6_RS16445 ENOG4106855 Competence protein WDLP6_RS16450 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) WDLP6_RS16455 ENOG4108R6K riboflavin synthase, subunit alpha WDLP6_RS16460 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) WDLP6_RS16465 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) WDLP6_RS16470 ENOG4107YIM Involved in the transcription termination process (By similarity) WDLP6_RS16475 ENOG4105CHM Aminotransferase WDLP6_RS16480 ENOG4107YD3 Thioesterase WDLP6_RS16485 ENOG4105E02 MotA TolQ exbB proton channel WDLP6_RS16490 ENOG4108ZZF transport protein (ExbD) WDLP6_RS16500 ENOG4105C0B DNA polymerase III (alpha subunit) WDLP6_RS16505 ENOG4105C72 UPF0176 protein WDLP6_RS16510 ENOG4105EUB pirin domain protein WDLP6_RS16520 ENOG4108VBZ doxx family WDLP6_RS16535 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) WDLP6_RS16540 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) WDLP6_RS16545 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) WDLP6_RS16555 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding WDLP6_RS16570 ENOG4107RQ2 Cytochrome c oxidase, subunit I WDLP6_RS16580 ENOG4107QZ7 Cellulose synthase catalytic subunit WDLP6_RS16585 ENOG4107EEX Cellulose synthase regulator protein WDLP6_RS16590 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) WDLP6_RS16595 ENOG4105EJG cellulose synthase WDLP6_RS16610 ENOG4105FDF Could be involved in DNA repair (By similarity) WDLP6_RS16620 ENOG4105C8Q Methyl-accepting chemotaxis WDLP6_RS16645 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A WDLP6_RS16650 ENOG4108Z6B deaminase WDLP6_RS16675 ENOG4108ZXC Two component transcriptional regulator, luxr family WDLP6_RS16680 ENOG4105BZU Histidine kinase WDLP6_RS16690 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr WDLP6_RS16695 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme WDLP6_RS16700 ENOG4108IV0 ABC, transporter WDLP6_RS16705 ENOG4105C0Z ABC transporter WDLP6_RS16715 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS16725 ENOG4105CHR reductase WDLP6_RS16735 ENOG4105EBR Carboxylesterase WDLP6_RS16750 ENOG4105CD5 CoA-binding domain protein WDLP6_RS16755 ENOG4105WH1 Two component transcriptional regulator luxr family WDLP6_RS16770 ENOG4105CSH Transporter WDLP6_RS16775 ENOG4105E2S oxidase) subunit II WDLP6_RS16780 ENOG4105BZ9 Cytochrome C oxidase, subunit I WDLP6_RS16785 ENOG4105CCU oxidase (Subunit III) WDLP6_RS16790 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) WDLP6_RS16795 ENOG4108R6F Surfeit locus 1 family protein WDLP6_RS16800 ENOG4105TX3 Histidine kinase WDLP6_RS16805 ENOG4108UYB regulatoR WDLP6_RS16815 ENOG4105FC8 fad dependent oxidoreductase WDLP6_RS16855 ENOG4105KME endoribonuclease L-psp WDLP6_RS16860 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) WDLP6_RS16875 ENOG4105C4Y ABC transporter WDLP6_RS16880 ENOG4107RCV ABC transporter, permease WDLP6_RS16890 ENOG4107SM8 Adenylate Guanylate cyclase WDLP6_RS16895 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WDLP6_RS16900 ENOG4107F9Y LysR family transcriptional regulator WDLP6_RS16930 ENOG4105C5I Dehydrogenase WDLP6_RS16940 ENOG4105CBN LysR family transcriptional regulator WDLP6_RS16950 ENOG41061H0 Monooxygenase WDLP6_RS16960 ENOG4105D5U fad dependent oxidoreductase WDLP6_RS16980 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS16995 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WDLP6_RS17000 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS17035 ENOG4105MP9 class II Aldolase WDLP6_RS17040 ENOG4105FP9 thiamine pyrophosphate WDLP6_RS17045 ENOG4105C26 Dehydrogenase WDLP6_RS17065 ENOG4108UKV benzoate 1,2-dioxygenase WDLP6_RS17100 ENOG4105ETT transcriptional Regulator, LysR family WDLP6_RS17110 ENOG4107EFR Flavocytochrome c WDLP6_RS17115 ENOG4105C26 Dehydrogenase WDLP6_RS17120 ENOG4105EQ2 LysR family Transcriptional regulator WDLP6_RS17130 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WDLP6_RS17165 ENOG4105CQB FAD linked oxidase domain protein WDLP6_RS17170 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase WDLP6_RS17180 ENOG4105KHC sulfurtransferase WDLP6_RS17195 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) WDLP6_RS17210 ENOG4105F8V Hydrolase, tatD family WDLP6_RS17220 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) WDLP6_RS17225 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WDLP6_RS17240 ENOG4108Z1B Cyclase dehydrase WDLP6_RS17245 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) WDLP6_RS17280 ENOG4105CI3 gtp-binding protein typa WDLP6_RS17285 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) WDLP6_RS17290 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) WDLP6_RS17300 ENOG4105CHV Transcription elongation factor NusA WDLP6_RS17305 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) WDLP6_RS17310 ENOG4105CBP Major Facilitator WDLP6_RS17315 ENOG4108JQ5 ABC transporter WDLP6_RS17320 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component WDLP6_RS17325 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component WDLP6_RS17335 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH WDLP6_RS17355 ENOG4105CXN decarboxylase WDLP6_RS17380 ENOG4105CP9 extracellular ligand-binding receptor WDLP6_RS17395 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) WDLP6_RS17415 ENOG4107R11 Transcriptional regulator WDLP6_RS17420 ENOG4105CHM Aminotransferase WDLP6_RS17430 ENOG4105CQ7 ATP-dependent helicase WDLP6_RS17435 ENOG4108EKC n-acetylglutamate synthase WDLP6_RS17440 ENOG4105CHM Aminotransferase WDLP6_RS17445 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) WDLP6_RS17450 ENOG4105CZX twitching motility protein WDLP6_RS17455 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) WDLP6_RS17460 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) WDLP6_RS17465 ENOG4105C5H ABC transporter WDLP6_RS17495 ENOG4107EFR Flavocytochrome c WDLP6_RS17525 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS17530 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein WDLP6_RS17560 ENOG4105EBM Alpha Beta Hydrolase Fold protein WDLP6_RS17570 ENOG4105CUZ uba thif-type nad fad binding protein WDLP6_RS17580 ENOG4105KCK Peptidoglycan-associated lipoprotein WDLP6_RS17585 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) WDLP6_RS17590 ENOG4105BZ1 (ABC) transporter WDLP6_RS17595 ENOG4105C03 ribonuclease WDLP6_RS17600 ENOG4108Z03 MAF-like protein WDLP6_RS17605 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) WDLP6_RS17610 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) WDLP6_RS17615 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) WDLP6_RS17620 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) WDLP6_RS17625 ENOG4105C12 Phosphoribosylglycinamide synthetase WDLP6_RS17630 ENOG4105CDY transcriptional regulatory protein WDLP6_RS17690 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) WDLP6_RS17705 ENOG4105D7A ATP-binding protein WDLP6_RS17710 ENOG4108ZJD Protein of unknown function (DUF1109) WDLP6_RS17715 ENOG4105NCT RNA Polymerase WDLP6_RS17725 ENOG4105E18 UPF0276 protein WDLP6_RS17750 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) WDLP6_RS17755 ENOG4107TFB basic membrane WDLP6_RS17760 ENOG4108JQ9 ABC transporter WDLP6_RS17765 ENOG4105UIB (ABC) transporter WDLP6_RS17775 ENOG4105DZC cytosine deaminase WDLP6_RS17780 ENOG4105CJB Exodeoxyribonuclease I WDLP6_RS17785 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WDLP6_RS17790 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WDLP6_RS17795 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) WDLP6_RS17830 ENOG4108ZZF transport protein (ExbD) WDLP6_RS17835 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) WDLP6_RS17840 ENOG4105W49 UPF0434 protein WDLP6_RS17845 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) WDLP6_RS17850 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) WDLP6_RS17865 ENOG4107RB3 L-asparaginase WDLP6_RS17870 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) WDLP6_RS17880 ENOG4108JQ1 Dehydrogenase WDLP6_RS17885 ENOG4105F27 Major Facilitator WDLP6_RS17895 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WDLP6_RS17900 ENOG4108UKI Enoyl-CoA hydratase WDLP6_RS17925 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) WDLP6_RS17930 ENOG4105EEI dihydropteroate synthase WDLP6_RS17935 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WDLP6_RS17940 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) WDLP6_RS17945 ENOG4105HBR Rna-binding protein WDLP6_RS17960 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) WDLP6_RS17970 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain WDLP6_RS17985 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WDLP6_RS17990 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WDLP6_RS17995 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WDLP6_RS18000 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) WDLP6_RS18005 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WDLP6_RS18015 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane WDLP6_RS18020 ENOG4105DZP Membrane-associated zinc metalloprotease WDLP6_RS18025 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) WDLP6_RS18030 ENOG4105KNE Phosphatidate cytidylyltransferase WDLP6_RS18035 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) WDLP6_RS18040 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) WDLP6_RS18045 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) WDLP6_RS18050 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) WDLP6_RS18055 ENOG4105CE9 30S ribosomal protein S2 WDLP6_RS18065 ENOG4105MWK D-amino acid dehydrogenase, small subunit WDLP6_RS18070 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) WDLP6_RS18075 ENOG41061TZ Short-chain dehydrogenase reductase Sdr WDLP6_RS18080 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) WDLP6_RS18090 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) WDLP6_RS18095 ENOG4108NVM synthesis repressor PhaR WDLP6_RS18110 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WDLP6_RS18115 ENOG4105DTD Dehydrogenase WDLP6_RS18135 ENOG4105E0F Histidine kinase WDLP6_RS18140 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) WDLP6_RS18145 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) WDLP6_RS18150 ENOG4108JA2 transcriptioN-repair coupling factor WDLP6_RS18155 ENOG4105EAC phosphoserine phosphatase WDLP6_RS18180 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WDLP6_RS18185 ENOG4105CSM endonuclease III WDLP6_RS18200 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) WDLP6_RS18205 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) WDLP6_RS18210 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) WDLP6_RS18215 ENOG4105ETP RND efflux system, outer membrane lipoprotein WDLP6_RS18225 ENOG4105C1P efflux transporter, rnd family, mfp subunit WDLP6_RS18240 ENOG4105CIH Imidazole acetol-phosphate transaminase WDLP6_RS18250 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase WDLP6_RS18255 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) WDLP6_RS18260 ENOG4105EHG Permease protein WDLP6_RS18270 ENOG4108YZT Adenosylcobinamide kinase WDLP6_RS18275 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) WDLP6_RS18290 ENOG4105HF0 Membrane WDLP6_RS18300 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS18320 ENOG4105DRR Transcriptional regulator, GntR family WDLP6_RS18330 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) WDLP6_RS18335 ENOG4106NZI LysR family Transcriptional regulator WDLP6_RS18340 ENOG4105C01 Dihydroxy-acid dehydratase WDLP6_RS18365 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) WDLP6_RS18370 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) WDLP6_RS18385 ENOG4105DQE DNA ligase WDLP6_RS18435 ENOG4105DEI Mannitol dehydrogenase WDLP6_RS18440 ENOG4105CHR reductase WDLP6_RS18445 ENOG4105EQD regulatoR WDLP6_RS18450 ENOG4105CMG Carbohydrate kinase WDLP6_RS18465 ENOG4105C0H protease WDLP6_RS18470 ENOG4105DHQ Histidine kinase WDLP6_RS18475 ENOG4105XJC Two component transcriptional regulator (Winged helix family WDLP6_RS18480 ENOG4107HP6 Transcriptional regulator WDLP6_RS18485 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase WDLP6_RS18495 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) WDLP6_RS18500 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate WDLP6_RS18505 ENOG41069M3 Transcriptional regulator WDLP6_RS18510 ENOG41061WM D-Alanyl-D-Alanine WDLP6_RS18515 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) WDLP6_RS18520 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) WDLP6_RS18525 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase WDLP6_RS18530 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WDLP6_RS18535 ENOG4108ZP8 Acetolactate synthase small subunit WDLP6_RS18540 ENOG4105C7K acetolactate synthase WDLP6_RS18565 ENOG41080IJ Diacylglycerol kinase WDLP6_RS18570 ENOG4108URH decarboxylase WDLP6_RS18575 ENOG4108YZA Nitrogen regulatory protein pii WDLP6_RS18585 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) WDLP6_RS18590 ENOG4105F0N pyrophosphate phospho-hydrolase WDLP6_RS18615 ENOG4107RZC phospholipase d WDLP6_RS18645 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS18670 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WDLP6_RS18675 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) WDLP6_RS18680 ENOG4105CVM Molybdenum cofactor synthesis domain protein WDLP6_RS18690 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WDLP6_RS18700 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WDLP6_RS18705 ENOG4105E9H Lytic Murein transglycosylase WDLP6_RS18710 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component WDLP6_RS18720 ENOG4105D2X ABC transporter substrate-binding protein WDLP6_RS18730 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) WDLP6_RS18735 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) WDLP6_RS18740 ENOG4107QMP dna polymerase iii subunits gamma and tau WDLP6_RS18825 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation WDLP6_RS18835 ENOG4105K63 Thioredoxin WDLP6_RS18840 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) WDLP6_RS18845 ENOG4105D9R oxidoreductase WDLP6_RS18850 ENOG4105NRA 50s ribosomal protein l31 type b WDLP6_RS18860 ENOG4107QI1 Mate efflux family protein WDLP6_RS18865 ENOG4105BZU Histidine kinase WDLP6_RS18870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WDLP6_RS18880 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) WDLP6_RS18885 ENOG4105E2Z phosphate ABC transporter (Permease WDLP6_RS18890 ENOG4105C8U phosphate abc transporter WDLP6_RS18895 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) WDLP6_RS18900 ENOG4105C9X ppx gppa phosphatase WDLP6_RS18910 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) WDLP6_RS18920 ENOG4108JU3 Alkyl hydroperoxide reductase WDLP6_RS18925 ENOG4105CYM Glutathione S-transferase WDLP6_RS18970 ENOG4107S8C mandelate racemase muconate lactonizing WDLP6_RS18980 ENOG4108UKI Enoyl-CoA hydratase WDLP6_RS18985 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS18990 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS19010 ENOG4107QRI Phosphoketolase WDLP6_RS19020 ENOG4105C0H protease WDLP6_RS19035 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic WDLP6_RS19040 ENOG41080TK Universal stress protein WDLP6_RS19045 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class WDLP6_RS19055 ENOG4105CHR reductase WDLP6_RS19070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WDLP6_RS19075 ENOG4105BZU Histidine kinase WDLP6_RS19115 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS19120 ENOG4105CC9 acyl-Coa dehydrogenase WDLP6_RS19145 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS19155 ENOG4105C26 Dehydrogenase WDLP6_RS19160 ENOG4105C7K acetolactate synthase WDLP6_RS19215 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) WDLP6_RS19220 ENOG4105CY0 Metallo-Beta-Lactamase WDLP6_RS19225 ENOG4105CD5 CoA-binding domain protein WDLP6_RS19240 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WDLP6_RS19255 ENOG4105DQQ Major facilitator superfamily MFS_1 WDLP6_RS19260 ENOG4105CRU nitrate reductase, alpha subunit WDLP6_RS19265 ENOG4108IUE nitrate reductase beta subunit WDLP6_RS19270 ENOG4105R3A Nitrate reductase WDLP6_RS19275 ENOG4105D0D Nitrate reductase 2, gamma subunit WDLP6_RS19315 ENOG4105VG1 fes assembly suf system protein WDLP6_RS19335 ENOG41062QD Membrane WDLP6_RS19340 ENOG4107QN1 sodium solute WDLP6_RS19360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WDLP6_RS19365 ENOG4108IRC dna polymerase iii WDLP6_RS19370 ENOG4105D0S secretion protein (HlyD WDLP6_RS19390 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) WDLP6_RS19395 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WDLP6_RS19425 ENOG41080HT Transcriptional regulator, arsr family WDLP6_RS19460 ENOG4107RZC phospholipase d WDLP6_RS19490 ENOG41080TK Universal stress protein WDLP6_RS19505 ENOG4107Y70 Heat shock protein WDLP6_RS19525 ENOG41080TK Universal stress protein WDLP6_RS19540 ENOG4108YV4 Universal stress protein WDLP6_RS19545 ENOG4105C0H protease WDLP6_RS19560 ENOG4105DS0 Transcriptional regulator, Crp Fnr family WDLP6_RS19595 ENOG41080TK Universal stress protein WDLP6_RS19605 ENOG4105D4P Coproporphyrinogen iii oxidase WDLP6_RS19610 ENOG4105DS0 Transcriptional regulator, Crp Fnr family WDLP6_RS19635 ENOG4105E2X shikimate dehydrogenase WDLP6_RS19645 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) WDLP6_RS19650 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein WDLP6_RS19655 ENOG4105CHR reductase WDLP6_RS19675 ENOG4108R85 Short chain dehydrogenase WDLP6_RS19685 ENOG4105CHR reductase WDLP6_RS19695 ENOG4105CHR reductase WDLP6_RS19710 ENOG4105C2J ABC transporter WDLP6_RS19715 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS19720 ENOG4105C6F GntR Family Transcriptional Regulator WDLP6_RS19725 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS19740 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS19760 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS19770 ENOG4105C0Z ABC transporter WDLP6_RS19775 ENOG4108IV0 ABC, transporter WDLP6_RS19790 ENOG4105C26 Dehydrogenase WDLP6_RS19795 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) WDLP6_RS19805 ENOG4107R11 Transcriptional regulator WDLP6_RS19815 ENOG4107EFR Flavocytochrome c WDLP6_RS19825 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS19840 ENOG4105DTQ mandelate racemase muconate lactonizing WDLP6_RS19855 ENOG4105C5I Dehydrogenase WDLP6_RS19870 ENOG4108IV0 ABC, transporter WDLP6_RS19875 ENOG4105C0Z ABC transporter WDLP6_RS19885 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS19895 ENOG41066T0 asmA family WDLP6_RS19920 ENOG41060WC Enoyl-CoA hydratase WDLP6_RS19935 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS19955 ENOG4107YZX Universal stress protein WDLP6_RS19965 ENOG4105CCT upf0313 protein WDLP6_RS19970 ENOG410645S MarR family Transcriptional regulator WDLP6_RS19995 ENOG4107S2Z UPF0761 membrane protein WDLP6_RS20010 ENOG4105CPC Aldo Keto reductase WDLP6_RS20035 ENOG4105C2N RNA methyltransferase TrmH family group 3 WDLP6_RS20040 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WDLP6_RS20045 ENOG4108UJV acyl-CoA thioesterase i WDLP6_RS20055 ENOG4105C28 cystathionine WDLP6_RS20070 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis WDLP6_RS20075 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) WDLP6_RS20085 ENOG4105EPW hflc protein WDLP6_RS20090 ENOG4107QJR hflk protein WDLP6_RS20095 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WDLP6_RS20100 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WDLP6_RS20105 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) WDLP6_RS20110 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) WDLP6_RS20120 ENOG4105CUT histidyl-tRNA synthetase WDLP6_RS20125 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) WDLP6_RS20140 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs WDLP6_RS20145 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) WDLP6_RS20150 ENOG4105FE9 pseudouridine synthase WDLP6_RS20155 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) WDLP6_RS20160 ENOG4105C34 Pseudouridine synthase WDLP6_RS20165 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane WDLP6_RS20170 ENOG4105DVT helicase WDLP6_RS20190 ENOG4105D6Z AFG1 family ATPase WDLP6_RS20195 ENOG4107QN2 dihydrolipoyl dehydrogenase WDLP6_RS20200 ENOG4105C7S Dehydrogenase WDLP6_RS20205 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 WDLP6_RS20210 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WDLP6_RS20220 ENOG4108PTX LysR family Transcriptional regulator WDLP6_RS20235 ENOG4108JUA Transcriptional regulator WDLP6_RS20240 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WDLP6_RS20245 ENOG41082A2 Alpha beta hydrolase WDLP6_RS20255 ENOG4105ER2 Ompa motb domain protein WDLP6_RS20275 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) WDLP6_RS20280 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WDLP6_RS20290 ENOG4105D8V Glucose sorbosone dehydrogenase WDLP6_RS20295 ENOG4105K4H Nlp p60 protein WDLP6_RS20330 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WDLP6_RS20335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WDLP6_RS20360 ENOG4107QN2 dihydrolipoyl dehydrogenase WDLP6_RS20365 ENOG4107QSN dihydrolipoamide acetyltransferase WDLP6_RS20370 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) WDLP6_RS20375 ENOG4105BZU Histidine kinase WDLP6_RS20380 ENOG4108ZXC Two component transcriptional regulator, luxr family WDLP6_RS20385 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) WDLP6_RS20390 ENOG4105DGW oligopeptidase A WDLP6_RS20400 ENOG4105E66 phosphoriboisomerase A WDLP6_RS20405 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) WDLP6_RS20420 ENOG4105D5U fad dependent oxidoreductase WDLP6_RS20435 ENOG4107RZZ dna polymerase iii epsilon subunit WDLP6_RS20440 ENOG4108ZIT Ferredoxin, 2FE-2S WDLP6_RS20445 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB WDLP6_RS20460 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins WDLP6_RS20465 ENOG4105C3J Cysteine desulfurase WDLP6_RS20470 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family WDLP6_RS20480 ENOG4105CGF Aromatic amino acid aminotransferase WDLP6_RS20490 ENOG4108R3D Electron transport complex WDLP6_RS20510 ENOG4107QX3 carboxylase WDLP6_RS20515 ENOG4105DJT lAO AO transport system ATPase WDLP6_RS20525 ENOG4105DRR Transcriptional regulator, GntR family WDLP6_RS20545 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WDLP6_RS20555 ENOG4107QRT dEAD DEAH box helicase WDLP6_RS20560 ENOG4105BZU Histidine kinase WDLP6_RS20590 ENOG4105CKD glutathione-regulated potassium-efflux system protein WDLP6_RS20595 ENOG4105CK2 sodium dicarboxylate symporter WDLP6_RS20600 ENOG4105CHR reductase WDLP6_RS20610 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS20615 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class WDLP6_RS20625 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase WDLP6_RS20645 ENOG4108RH0 Crea protein WDLP6_RS20650 ENOG4108K5P (LipO)protein WDLP6_RS20655 ENOG4107RZC phospholipase d WDLP6_RS20670 ENOG4105F04 LysR family Transcriptional regulator WDLP6_RS20675 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) WDLP6_RS20700 ENOG4105CHR reductase WDLP6_RS20710 ENOG410900P UPF0336 protein WDLP6_RS20720 ENOG4108UKI Enoyl-CoA hydratase WDLP6_RS20725 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS20730 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS20740 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS20760 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS20765 ENOG4108IV0 ABC, transporter WDLP6_RS20770 ENOG4105C0Z ABC transporter WDLP6_RS20775 ENOG4108KQI regulatory protein luxr WDLP6_RS20790 ENOG4105ETT transcriptional Regulator, LysR family WDLP6_RS20795 ENOG4108K3A Glutathione S-transferase WDLP6_RS20810 ENOG4105FDP GntR family transcriptional regulator WDLP6_RS20840 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS20845 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS20850 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS20905 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WDLP6_RS20910 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) WDLP6_RS20945 ENOG4105DVF Cytosine-specific methyltransferase WDLP6_RS21015 ENOG4106NZI LysR family Transcriptional regulator WDLP6_RS21035 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WDLP6_RS21045 ENOG4108JQ6 ABC transporter WDLP6_RS21050 ENOG4105MP9 class II Aldolase WDLP6_RS21055 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WDLP6_RS21070 ENOG4105DVW rieske (2Fe-2S) WDLP6_RS21080 ENOG4105C26 Dehydrogenase WDLP6_RS21085 ENOG4108JPW Aminotransferase WDLP6_RS21095 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase WDLP6_RS21100 ENOG4105MP9 class II Aldolase WDLP6_RS21145 ENOG4105DND Transcriptional regulator WDLP6_RS21160 ENOG41082A2 Alpha beta hydrolase WDLP6_RS21165 ENOG4105DVW rieske (2Fe-2S) WDLP6_RS21175 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) WDLP6_RS21190 ENOG4105DVW rieske (2Fe-2S) WDLP6_RS21230 ENOG4108UAU isochorismatase WDLP6_RS21280 ENOG4107QJE Chromosome Partitioning Protein WDLP6_RS21320 ENOG4105FA0 parb-like partition protein WDLP6_RS21335 ENOG4105W5Q DNA repair protein (RadC WDLP6_RS21355 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) WDLP6_RS21360 ENOG4105ETE Transcriptional regulator (LacI family WDLP6_RS21365 ENOG4107XWI flavin reductase domain protein, FMN-binding WDLP6_RS21375 ENOG4105D7T ABC transporter WDLP6_RS21385 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component WDLP6_RS21390 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS21415 ENOG4105C26 Dehydrogenase WDLP6_RS21430 ENOG4105C10 Electron transfer flavoprotein WDLP6_RS21435 ENOG4105BZJ Electron transfer flavoprotein WDLP6_RS21450 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS21465 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS21480 ENOG4105HEI LysR family (Transcriptional regulator WDLP6_RS21485 ENOG4105DFP Integrase WDLP6_RS21500 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) WDLP6_RS21510 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) WDLP6_RS21515 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) WDLP6_RS21520 ENOG4105VJV 50s ribosomal protein L35 WDLP6_RS21525 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) WDLP6_RS21530 ENOG4105C22 threonyL-tRNA synthetase WDLP6_RS21535 ENOG4108I9X Isocitrate lyase WDLP6_RS21560 ENOG4108W9H Tetr family transcriptional regulator WDLP6_RS21605 ENOG4107TTA Xylose isomerase domain protein TIM barrel WDLP6_RS21625 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) WDLP6_RS21645 ENOG4105CHH sulfate transporter WDLP6_RS21650 ENOG4108YZN class I peptide chain release factor WDLP6_RS21665 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WDLP6_RS21685 ENOG4106NZI LysR family Transcriptional regulator WDLP6_RS21695 ENOG4108ZAF Molybdopterin WDLP6_RS21700 ENOG4105M00 molybdopterin converting factor, subunit 1 WDLP6_RS21705 ENOG4105CVM Molybdenum cofactor synthesis domain protein WDLP6_RS21710 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b WDLP6_RS21715 ENOG4105D98 threonine synthase WDLP6_RS21720 ENOG4105D6E homoserine dehydrogenase WDLP6_RS21725 ENOG4105CHM Aminotransferase WDLP6_RS21735 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WDLP6_RS21740 ENOG4108IAB Phoh family WDLP6_RS21755 ENOG4105CDU Replicative dna helicase WDLP6_RS21760 ENOG4105K9Q Binds to the 23S rRNA (By similarity) WDLP6_RS21765 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) WDLP6_RS21775 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) WDLP6_RS21785 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) WDLP6_RS21790 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) WDLP6_RS21805 ENOG4108JU3 Alkyl hydroperoxide reductase WDLP6_RS21810 ENOG4105D3R alkyl hydroperoxide reductase WDLP6_RS21815 ENOG4108UQY Iron-storage protein WDLP6_RS21825 ENOG4105HB4 Pathways of utilization of iron bound to transferrin, lactoferrin and hemoglobin but not to haemin or citrate where dependent on the TonB system WDLP6_RS21835 ENOG4105M8F Biopolymer transport protein exbD tolR WDLP6_RS21845 ENOG4108ZJF Glcg protein WDLP6_RS21850 ENOG4108MN8 Membrane WDLP6_RS21855 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WDLP6_RS21860 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WDLP6_RS21865 ENOG4108K5P (LipO)protein WDLP6_RS21870 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) WDLP6_RS21875 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) WDLP6_RS21920 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WDLP6_RS22130 ENOG4107RHI Cytosine-specific methyltransferase WDLP6_RS22165 ENOG4108XTP Transcriptional regulator WDLP6_RS22220 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) WDLP6_RS22270 ENOG4107TF3 peptidylprolyl cis-trans isomerase WDLP6_RS22285 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) WDLP6_RS22295 ENOG4106855 Competence protein WDLP6_RS22345 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) WDLP6_RS22355 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) WDLP6_RS22375 ENOG4105C5I Dehydrogenase WDLP6_RS22385 ENOG4107RH7 Nicotinate phosphoribosyltransferase WDLP6_RS22390 ENOG4105VDW Csbd family WDLP6_RS22405 ENOG4105DGU Histone deacetylase WDLP6_RS22410 ENOG4108WFY phasin family WDLP6_RS22420 ENOG4107S2Z UPF0761 membrane protein WDLP6_RS22425 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) WDLP6_RS22430 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WDLP6_RS22435 ENOG4105C2C drug resistance transporter, Bcr CflA WDLP6_RS22450 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS22455 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase WDLP6_RS22475 ENOG4108IV0 ABC, transporter WDLP6_RS22480 ENOG4105C0Z ABC transporter WDLP6_RS22505 ENOG4108WYP Transcriptional regulator WDLP6_RS22525 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WDLP6_RS22540 ENOG4105E90 ABC transporter WDLP6_RS22545 ENOG4105C26 Dehydrogenase WDLP6_RS22550 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase WDLP6_RS22560 ENOG4107YCY Transcriptional regulator WDLP6_RS22565 ENOG4105E9Z Nad-dependent epimerase dehydratase WDLP6_RS22570 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit WDLP6_RS22580 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS22585 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) WDLP6_RS22590 ENOG4105CTX dehydratase WDLP6_RS22595 ENOG4105CHR reductase WDLP6_RS22600 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) WDLP6_RS22610 ENOG4105DJ4 phosphatidylserine decarboxylase WDLP6_RS22620 ENOG4108V1T peptidylprolyl cis-trans isomerase WDLP6_RS22625 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ WDLP6_RS22630 ENOG4105CFG Acts as a chaperone (By similarity) WDLP6_RS22635 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) WDLP6_RS22640 ENOG41073TP transcriptional regulator WDLP6_RS22645 ENOG4105ERH Fumarylacetoacetate hydrolase WDLP6_RS22655 ENOG4105CYN Serine protein kinase WDLP6_RS22660 ENOG4106AKX UPF0229 protein WDLP6_RS22665 ENOG4105ED1 spovr family WDLP6_RS22670 ENOG4108R3E Dna-3-methyladenine glycosylase i WDLP6_RS22675 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) WDLP6_RS22680 ENOG4107YCY Transcriptional regulator WDLP6_RS22705 ENOG4107QPD alcohol dehydrogenase WDLP6_RS22715 ENOG4105C4W S-formylglutathione hydrolase WDLP6_RS22720 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family WDLP6_RS22735 ENOG4105ENJ RND efflux system, outer membrane lipoprotein WDLP6_RS22750 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WDLP6_RS22760 ENOG4107RZC phospholipase d WDLP6_RS22765 ENOG41080XP Cbs domain WDLP6_RS22775 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WDLP6_RS22780 ENOG4105K4T epimerase WDLP6_RS22785 ENOG4105K63 Thioredoxin WDLP6_RS22790 ENOG4107S2Z UPF0761 membrane protein WDLP6_RS22800 ENOG4105CQB FAD linked oxidase domain protein WDLP6_RS22805 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) WDLP6_RS22855 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WDLP6_RS22860 ENOG4105D7T ABC transporter WDLP6_RS22865 ENOG4105C2J ABC transporter WDLP6_RS22875 ENOG4105CNN ABC, transporter WDLP6_RS22880 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator WDLP6_RS22885 ENOG4105CNN ABC, transporter WDLP6_RS22900 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS22905 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WDLP6_RS22920 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS22935 ENOG4105CGK Exodeoxyribonuclease III WDLP6_RS22945 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WDLP6_RS22950 ENOG4105CUX Signal transduction histidine kinase WDLP6_RS22965 ENOG4107TH8 cina domain protein WDLP6_RS22990 ENOG4105I08 Pseudouridine synthase WDLP6_RS23000 ENOG4106R49 Methyltransferase WDLP6_RS23015 ENOG4105E6M Sulphatase-modifying factor protein WDLP6_RS23020 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) WDLP6_RS23025 ENOG4105CPQ Dehydrogenase WDLP6_RS23040 ENOG4105ERH Fumarylacetoacetate hydrolase WDLP6_RS23060 ENOG4107R11 Transcriptional regulator WDLP6_RS23075 ENOG4105CQB FAD linked oxidase domain protein WDLP6_RS23080 ENOG4105C26 Dehydrogenase WDLP6_RS23090 ENOG4105ERH Fumarylacetoacetate hydrolase WDLP6_RS23095 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WDLP6_RS23105 ENOG4105C26 Dehydrogenase WDLP6_RS23115 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS23120 ENOG4105MP9 class II Aldolase WDLP6_RS23125 ENOG4107RSM transcriptional regulator WDLP6_RS23140 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS23145 ENOG4105ENH Sulfatase WDLP6_RS23155 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) WDLP6_RS23160 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) WDLP6_RS23165 ENOG4105UYK outer membrane protein a WDLP6_RS23170 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WDLP6_RS23180 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) WDLP6_RS23185 ENOG4105CQC Prephenate dehydratase WDLP6_RS23195 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase WDLP6_RS23200 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) WDLP6_RS23215 ENOG4105CFV Tetratricopeptide repeat protein WDLP6_RS23235 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS23240 ENOG4107Z6W Protein CrcB homolog WDLP6_RS23245 ENOG4105D65 subunit l WDLP6_RS23250 ENOG4108ZE9 Monovalent cation H antiporter subunit C WDLP6_RS23255 ENOG4107R4Z monovalent cation h antiporter subunit d WDLP6_RS23265 ENOG4105W4C monovalent cation H antiporter subunit F WDLP6_RS23270 ENOG4105KJM monovalent cation h antiporter subunit g WDLP6_RS23305 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) WDLP6_RS23335 ENOG4107T8Q Glycosyl transferase (Group 1 WDLP6_RS23345 ENOG4105CPQ Dehydrogenase WDLP6_RS23355 ENOG4108YYC ycei family WDLP6_RS23370 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family WDLP6_RS23385 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) WDLP6_RS23415 ENOG4108IJ0 Aspartate ammonia-lyase WDLP6_RS23420 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) WDLP6_RS23425 ENOG4105F4R Transcriptional regulator mode WDLP6_RS23430 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein WDLP6_RS23435 ENOG4105E0C molybdate abc transporter WDLP6_RS23440 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) WDLP6_RS23455 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WDLP6_RS23460 ENOG4105F0N pyrophosphate phospho-hydrolase WDLP6_RS23465 ENOG4105MWK D-amino acid dehydrogenase, small subunit WDLP6_RS23480 ENOG4108JJB ABC transporter WDLP6_RS23490 ENOG4105F4R Transcriptional regulator mode WDLP6_RS23510 ENOG4108IV0 ABC, transporter WDLP6_RS23515 ENOG4105C0Z ABC transporter WDLP6_RS23530 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WDLP6_RS23535 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit WDLP6_RS23540 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit WDLP6_RS23545 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit WDLP6_RS23550 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit WDLP6_RS23560 ENOG4108ZJI phenylacetic acid degradation protein WDLP6_RS23565 ENOG4108UKI Enoyl-CoA hydratase WDLP6_RS23570 ENOG4108Z0R Transferase WDLP6_RS23575 ENOG4108IG5 Transcriptional regulator WDLP6_RS23580 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process WDLP6_RS23590 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS23600 ENOG4105CH5 extracellular solute-binding protein, family 7 WDLP6_RS23605 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) WDLP6_RS23610 ENOG4105CTB Polyprenyl synthetase WDLP6_RS23615 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) WDLP6_RS23630 ENOG4105KHC sulfurtransferase WDLP6_RS23640 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WDLP6_RS23655 ENOG4105WKW Pfam:DUF1458 WDLP6_RS23670 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) WDLP6_RS23680 ENOG4107RP9 extracellular solute-binding protein, family 3 WDLP6_RS23685 ENOG4105MWK D-amino acid dehydrogenase, small subunit WDLP6_RS23700 ENOG4105C2M dna polymerase I WDLP6_RS23710 ENOG4105CUV Homoserine Kinase WDLP6_RS23720 ENOG4105C4R Atp-dependent dna helicase WDLP6_RS23730 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) WDLP6_RS23740 ENOG4105CHR reductase WDLP6_RS23745 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS23760 ENOG4105C1J atp-dependent rna helicase WDLP6_RS23765 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) WDLP6_RS23770 ENOG4105D0M Protease HtpX homolog WDLP6_RS23775 ENOG41090A4 Pterin carbinolamine dehydratase WDLP6_RS23780 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) WDLP6_RS23785 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) WDLP6_RS23790 ENOG4105CIH Imidazole acetol-phosphate transaminase WDLP6_RS23795 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) WDLP6_RS23800 ENOG4105P8F nudix hydrolase WDLP6_RS23805 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) WDLP6_RS23810 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) WDLP6_RS23815 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) WDLP6_RS23820 ENOG4105K5M 30s ribosomal protein S16 WDLP6_RS23835 ENOG4107QXV Phosphate transporter WDLP6_RS23840 ENOG4107GRR phosphate transport regulator WDLP6_RS23845 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase WDLP6_RS23850 ENOG4105DJ0 Poly(A) Polymerase WDLP6_RS23855 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) WDLP6_RS23860 ENOG4105CXB phosphoribosylaminoimidazole synthetase WDLP6_RS23870 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) WDLP6_RS23890 ENOG4105CJR Integral membrane protein (MviN WDLP6_RS23895 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) WDLP6_RS23905 ENOG4105C8Y Acetylornithine aminotransferase WDLP6_RS23910 ENOG4105DBV ornithine carbamoyltransferase WDLP6_RS23915 ENOG4105C26 Dehydrogenase WDLP6_RS23920 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) WDLP6_RS23930 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) WDLP6_RS23945 ENOG4105MSY salicylate hydroxylase WDLP6_RS23955 ENOG4105CE1 Ferrous iron transport protein b WDLP6_RS23965 ENOG4107QM5 aconitate hydratase WDLP6_RS23980 ENOG4107QIJ Aconitate hydratase 2 WDLP6_RS23990 ENOG4105CI0 Citrate lyase WDLP6_RS23995 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) WDLP6_RS24000 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WDLP6_RS24005 ENOG4105FDP GntR family transcriptional regulator WDLP6_RS24020 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) WDLP6_RS24025 ENOG4105E33 succinate dehydrogenase WDLP6_RS24030 ENOG41060IS Flavinator of succinate dehydrogenase WDLP6_RS24035 ENOG4105BZN citrate synthase WDLP6_RS24050 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS24055 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS24060 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) WDLP6_RS24065 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WDLP6_RS24075 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) WDLP6_RS24080 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase WDLP6_RS24085 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) WDLP6_RS24090 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) WDLP6_RS24095 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) WDLP6_RS24100 ENOG4108VIA integral membrane protein WDLP6_RS24110 ENOG4105CRK lysyL-tRNA synthetase WDLP6_RS24115 ENOG4105R8A Heat shock protein WDLP6_RS24120 ENOG4108VKG metal-dependent hydrolase WDLP6_RS24125 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) WDLP6_RS24130 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) WDLP6_RS24135 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) WDLP6_RS24140 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) WDLP6_RS24145 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) WDLP6_RS24150 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) WDLP6_RS24160 ENOG4105C3F Signal peptidase i WDLP6_RS24165 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) WDLP6_RS24170 ENOG4105C0H protease WDLP6_RS24185 ENOG4105EMN RNA polymerase sigma factor WDLP6_RS24190 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WDLP6_RS24195 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) WDLP6_RS24200 ENOG4105CHR reductase WDLP6_RS24205 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WDLP6_RS24210 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) WDLP6_RS24215 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) WDLP6_RS24220 ENOG4105VGS 50s ribosomal protein l32 WDLP6_RS24225 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein WDLP6_RS24230 ENOG4108UHJ MAF-like protein WDLP6_RS24235 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) WDLP6_RS24240 ENOG4106UW1 Major Facilitator superfamily WDLP6_RS24245 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) WDLP6_RS24260 ENOG4105EI2 Pseudouridine synthase WDLP6_RS24265 ENOG4105C03 ribonuclease WDLP6_RS24270 ENOG4105D3Q Sugar transferase WDLP6_RS24275 ENOG4105CJT Mannose-1-phosphate guanylyltransferase WDLP6_RS24280 ENOG4105C30 Nad-dependent epimerase dehydratase WDLP6_RS24300 ENOG4106CD9 glycosyl transferase group 1 WDLP6_RS24335 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) WDLP6_RS24340 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) WDLP6_RS24345 ENOG410642W LysR family Transcriptional regulator WDLP6_RS24350 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WDLP6_RS24370 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS24375 ENOG4108IV0 ABC, transporter WDLP6_RS24380 ENOG4105C0Z ABC transporter WDLP6_RS24390 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) WDLP6_RS24400 ENOG4105MWK D-amino acid dehydrogenase, small subunit WDLP6_RS24405 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WDLP6_RS24410 ENOG4105W8H transhydrogenase (subunit alpha WDLP6_RS24415 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WDLP6_RS24420 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) WDLP6_RS24425 ENOG41069HH 4-oxalocrotonate tautomerase WDLP6_RS24455 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WDLP6_RS24465 ENOG4108WYP Transcriptional regulator WDLP6_RS24475 ENOG4105CKI cobalamin synthesis protein WDLP6_RS24485 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) WDLP6_RS24495 ENOG4105DTQ mandelate racemase muconate lactonizing WDLP6_RS24535 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) WDLP6_RS24550 ENOG4105D1Q UPF0246 protein WDLP6_RS24560 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WDLP6_RS24570 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) WDLP6_RS24575 ENOG4105E09 nadh pyrophosphatase WDLP6_RS24580 ENOG4105C6T cysteine synthase WDLP6_RS24590 ENOG4105VFU Rna-binding protein WDLP6_RS24605 ENOG4105CK2 sodium dicarboxylate symporter WDLP6_RS24615 ENOG4105WH1 Two component transcriptional regulator luxr family WDLP6_RS24620 ENOG4105C0H protease WDLP6_RS24645 ENOG4108IV0 ABC, transporter WDLP6_RS24650 ENOG4105C0Z ABC transporter WDLP6_RS24655 ENOG4105CF8 branched-chain amino acid ABC transporter, permease WDLP6_RS24660 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS24665 ENOG4105D1H recombination factor protein RarA WDLP6_RS24670 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) WDLP6_RS24675 ENOG4105CNU cell division protein FtsK WDLP6_RS24685 ENOG4105C3M thioredoxin reductase WDLP6_RS24690 ENOG4105KDC 50s ribosomal protein l28 WDLP6_RS24695 ENOG4105W0E 50S ribosomal protein L33 WDLP6_RS24710 ENOG4108V3E phosphoribosylglycinamide formyltransferase WDLP6_RS24715 ENOG4105CC9 acyl-Coa dehydrogenase WDLP6_RS24720 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS24730 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS24740 ENOG4105DTN riboflavin biosynthesis protein ribF WDLP6_RS24750 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) WDLP6_RS24755 ENOG4105EAM Na Pi-cotransporter WDLP6_RS24760 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein WDLP6_RS24775 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) WDLP6_RS24780 ENOG4108JQ7 (ABC) transporter WDLP6_RS24795 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) WDLP6_RS24800 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein WDLP6_RS24805 ENOG4105JQN Transcriptional regulator WDLP6_RS24810 ENOG4105CHR reductase WDLP6_RS24820 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) WDLP6_RS24840 ENOG4107QHF type ii secretion system protein e WDLP6_RS24845 ENOG4105I7M spermidine synthase WDLP6_RS24865 ENOG4105C0H protease WDLP6_RS24870 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WDLP6_RS24890 ENOG4105RQF LysR family Transcriptional regulator WDLP6_RS24900 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) WDLP6_RS24915 ENOG4106KNT transcriptional regulator WDLP6_RS24975 ENOG4105CAF HipA N-terminal domain protein WDLP6_RS24985 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WDLP6_RS25000 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) WDLP6_RS25020 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WDLP6_RS25025 ENOG4105BZU Histidine kinase WDLP6_RS25030 ENOG4108YZ9 Urea amidohydrolase subunit gamma WDLP6_RS25040 ENOG4105KI2 Urea amidohydrolase subunit beta WDLP6_RS25045 ENOG4105CQM Urea amidohydrolase subunit alpha WDLP6_RS25060 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) WDLP6_RS25065 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) WDLP6_RS25070 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) WDLP6_RS25080 ENOG4105E2B Taurine dioxygenase WDLP6_RS25095 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein WDLP6_RS25105 ENOG4108Z9W Outer membrane porin WDLP6_RS25115 ENOG4105C7K acetolactate synthase WDLP6_RS25155 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WDLP6_RS25165 ENOG4107R11 Transcriptional regulator WDLP6_RS25170 ENOG4105MP9 class II Aldolase WDLP6_RS25180 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component WDLP6_RS25190 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS25200 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) WDLP6_RS25205 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase WDLP6_RS25225 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WDLP6_RS25265 ENOG4105CSA Coproporphyrinogen iii oxidase WDLP6_RS25270 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) WDLP6_RS25275 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) WDLP6_RS25285 ENOG4105D9P serine threonine protein kinase WDLP6_RS25290 ENOG4105DSJ YicC domain protein WDLP6_RS25295 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) WDLP6_RS25300 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) WDLP6_RS25305 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WDLP6_RS25310 ENOG4108RRZ Transcription elongation factor GreB WDLP6_RS25320 ENOG4105IKQ hydratase WDLP6_RS25325 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) WDLP6_RS25330 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) WDLP6_RS25350 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) WDLP6_RS25355 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme WDLP6_RS25360 ENOG4105CYX Short-chain dehydrogenase reductase Sdr WDLP6_RS25375 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS25425 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WDLP6_RS25435 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) WDLP6_RS25440 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) WDLP6_RS25445 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) WDLP6_RS25450 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) WDLP6_RS25455 ENOG4105CEN a g-specific adenine glycosylase WDLP6_RS25460 ENOG410890F Dynamin family WDLP6_RS25465 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) WDLP6_RS25480 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) WDLP6_RS25490 ENOG4105C5T Phosphoribosyl pyrophosphate synthase WDLP6_RS25495 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) WDLP6_RS25500 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) WDLP6_RS25510 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding WDLP6_RS25520 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WDLP6_RS25530 ENOG4108JQ7 (ABC) transporter WDLP6_RS25535 ENOG4105DEF Extracellular solute-binding protein, family 5 WDLP6_RS25540 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WDLP6_RS25545 ENOG4107NQ8 LysR family Transcriptional regulator WDLP6_RS25565 ENOG4108NIW Leucine export protein LeuE WDLP6_RS25575 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) WDLP6_RS25580 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) WDLP6_RS25585 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) WDLP6_RS25590 ENOG4105E7W lamb ycsf family protein WDLP6_RS25595 ENOG4107R7A Allophanate hydrolase subunit 2 WDLP6_RS25600 ENOG4105P4J Allophanate hydrolase, subunit 1 WDLP6_RS25605 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) WDLP6_RS25610 ENOG4106H78 methyltransferase WDLP6_RS25635 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WDLP6_RS25645 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) WDLP6_RS25670 ENOG4107QS1 Cytochrome C Oxidase, Subunit III WDLP6_RS25680 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) WDLP6_RS25685 ENOG4105BZ9 Cytochrome C oxidase, subunit I WDLP6_RS25700 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WDLP6_RS25710 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) WDLP6_RS25725 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein WDLP6_RS25740 ENOG4105E9F Enoyl-CoA hydratase WDLP6_RS25765 ENOG4105CSU acyl-Coa dehydrogenase WDLP6_RS25785 ENOG4105CIF Ornithine Cyclodeaminase WDLP6_RS25790 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WDLP6_RS25820 ENOG4105CG6 trap dicarboxylate transporter dctm subunit WDLP6_RS25830 ENOG4105CH5 extracellular solute-binding protein, family 7 WDLP6_RS25870 ENOG4105RE0 Asp Glu hydantoin racemase WDLP6_RS25885 ENOG4108UAU isochorismatase WDLP6_RS25890 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS25895 ENOG4107QNJ CoA-transferase subunit B WDLP6_RS25905 ENOG4107HP6 Transcriptional regulator WDLP6_RS25910 ENOG4105K70 DNA-binding protein WDLP6_RS25915 ENOG4105DIA mandelate racemase muconate lactonizing WDLP6_RS25950 ENOG4108TJN glycosyl transferase group 1 WDLP6_RS25965 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS25975 ENOG4105C2C drug resistance transporter, Bcr CflA WDLP6_RS25985 ENOG4105CHR reductase WDLP6_RS25990 ENOG4105CBK multidrug resistance protein WDLP6_RS26005 ENOG4105CS1 NAD(P)H quinone oxidoreductase WDLP6_RS26035 ENOG4108IV0 ABC, transporter WDLP6_RS26040 ENOG4105C0Z ABC transporter WDLP6_RS26045 ENOG4105CF8 branched-chain amino acid ABC transporter, permease WDLP6_RS26050 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS26060 ENOG4105Q56 cytochrome P450 WDLP6_RS26085 ENOG41061TZ Short-chain dehydrogenase reductase Sdr WDLP6_RS26090 ENOG4105NI3 Protein of unknown function (DUF3237) WDLP6_RS26105 ENOG4105CF8 branched-chain amino acid ABC transporter, permease WDLP6_RS26110 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS26115 ENOG4108IV0 ABC, transporter WDLP6_RS26120 ENOG4105C0Z ABC transporter WDLP6_RS26125 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein WDLP6_RS26135 ENOG4105CHR reductase WDLP6_RS26180 ENOG4105Q56 cytochrome P450 WDLP6_RS26190 ENOG4105D44 asparaginase WDLP6_RS26195 ENOG4108JQ6 ABC transporter WDLP6_RS26200 ENOG4105DEF Extracellular solute-binding protein, family 5 WDLP6_RS26210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WDLP6_RS26230 ENOG4108VAU general secretion pathway protein G WDLP6_RS26240 ENOG4105GVR general secretion pathway protein D WDLP6_RS26265 ENOG4107QHF type ii secretion system protein e WDLP6_RS26275 ENOG4108VAU general secretion pathway protein G WDLP6_RS26320 ENOG4105DDW LysR family Transcriptional regulator WDLP6_RS26335 ENOG4106RE7 Cytochrome WDLP6_RS26340 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WDLP6_RS26390 ENOG4108Z20 Acyl-transferase WDLP6_RS26395 ENOG4105CD3 dihydroorotase WDLP6_RS26400 ENOG4105CXT aspartate transcarbamylase WDLP6_RS26405 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) WDLP6_RS26410 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) WDLP6_RS26415 ENOG4108UJU UPF0301 protein WDLP6_RS26420 ENOG4105CVP deoxyribo-dipyrimidine photolyase WDLP6_RS26430 ENOG4105C8Q Methyl-accepting chemotaxis WDLP6_RS26440 ENOG4105M3Z response regulator WDLP6_RS26445 ENOG4108UNF response regulator WDLP6_RS26450 ENOG4105VCQ rubredoxin WDLP6_RS26460 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase WDLP6_RS26465 ENOG4105DC1 bifunctional purine biosynthesis protein purh WDLP6_RS26475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WDLP6_RS26480 ENOG4105W39 Membrane WDLP6_RS26485 ENOG4105C3G gtp-binding protein WDLP6_RS26490 ENOG4105QVC MOSC domain-containing protein WDLP6_RS26495 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family WDLP6_RS26510 ENOG4105E39 Enoyl-CoA hydratase WDLP6_RS26565 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) WDLP6_RS26570 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase WDLP6_RS26575 ENOG4105E8V Alpha Beta Hydrolase Fold protein WDLP6_RS26580 ENOG41077RS Phosphatase WDLP6_RS26595 ENOG4108HPI phosphatidate Cytidylyltransferase WDLP6_RS26600 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) WDLP6_RS26605 ENOG4105C9A Phoh family WDLP6_RS26610 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) WDLP6_RS26615 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) WDLP6_RS26640 ENOG4105DR5 peptidase WDLP6_RS26645 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) WDLP6_RS26650 ENOG4105C0R drug resistance transporter emrb qaca subfamily WDLP6_RS26655 ENOG4108YX9 iron--sulfur cluster insertion protein erpA WDLP6_RS26660 ENOG4108UJD 30S ribosomal protein S9 WDLP6_RS26665 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) WDLP6_RS26670 ENOG4105D6S protein involved in catabolism of external DNA WDLP6_RS26680 ENOG4105SYT Methylenetetrahydrofolate reductase WDLP6_RS26690 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) WDLP6_RS26695 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) WDLP6_RS26710 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS26720 ENOG4105CSH Transporter WDLP6_RS26740 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase WDLP6_RS26745 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase WDLP6_RS26755 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) WDLP6_RS26760 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) WDLP6_RS26765 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) WDLP6_RS26780 ENOG4108IPT Naphthoate synthase WDLP6_RS26790 ENOG4107QX3 carboxylase WDLP6_RS26795 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS26800 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS26815 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 WDLP6_RS26820 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) WDLP6_RS26835 ENOG4105K5B UPF0225 protein WDLP6_RS26845 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS26860 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS26865 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) WDLP6_RS26870 ENOG41077A9 carbonic anhydrase WDLP6_RS26875 ENOG4108Z6Z Transcriptional regulator WDLP6_RS26890 ENOG4105EI2 Pseudouridine synthase WDLP6_RS26895 ENOG4105CHR reductase WDLP6_RS26910 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase WDLP6_RS26915 ENOG4105C38 Glycyl-tRNA synthetase beta subunit WDLP6_RS26920 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit WDLP6_RS26925 ENOG4105HDK L-asparaginase WDLP6_RS26935 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) WDLP6_RS26940 ENOG4108JU5 Magnesium and cobalt efflux protein WDLP6_RS26950 ENOG4105J0Q Transcriptional regulator WDLP6_RS26960 ENOG4105F87 Dehydratase WDLP6_RS26965 ENOG4105MIR Phenylalanine 4-monooxygenase WDLP6_RS26975 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS27005 ENOG4105C5H ABC transporter WDLP6_RS27010 ENOG4107RZC phospholipase d WDLP6_RS27015 ENOG4105CHM Aminotransferase WDLP6_RS27025 ENOG4105T38 integral membrane protein WDLP6_RS27030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WDLP6_RS27040 ENOG4108NIW Leucine export protein LeuE WDLP6_RS27045 ENOG4108TGY Glutathione S-transferase WDLP6_RS27050 ENOG4105JAB phenazine biosynthesis protein, phzf family WDLP6_RS27075 ENOG4105F4K antigen 43 WDLP6_RS27085 ENOG4105VF7 tolerance protein WDLP6_RS27100 ENOG4108V1U phospholipid-binding protein WDLP6_RS27115 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WDLP6_RS27120 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) WDLP6_RS27125 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WDLP6_RS27130 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) WDLP6_RS27135 ENOG4105C25 Primosomal protein n' WDLP6_RS27150 ENOG4105RK9 auxin efflux carrier WDLP6_RS27155 ENOG4105C4R Atp-dependent dna helicase WDLP6_RS27165 ENOG4105HDD phospholipase WDLP6_RS27175 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein WDLP6_RS27200 ENOG41073TP transcriptional regulator WDLP6_RS27260 ENOG4107NQ8 LysR family Transcriptional regulator WDLP6_RS27300 ENOG4105JN3 extra-cytoplasmic solute receptor family protein WDLP6_RS27315 ENOG4105CC9 acyl-Coa dehydrogenase WDLP6_RS27320 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS27325 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS27335 ENOG4105EA8 2-Nitropropane dioxygenase WDLP6_RS27345 ENOG4105CGU Enoyl-CoA hydratase WDLP6_RS27350 ENOG4105CHR reductase WDLP6_RS27365 ENOG4105CGU Enoyl-CoA hydratase WDLP6_RS27395 ENOG4108WYP Transcriptional regulator WDLP6_RS27400 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein WDLP6_RS27405 ENOG4108IY8 ABC, transporter WDLP6_RS27410 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WDLP6_RS27460 ENOG4105DSP amino acid AbC transporter WDLP6_RS27465 ENOG4105EAD ABC transporter WDLP6_RS27480 ENOG4105CBG Sulfatase WDLP6_RS27485 ENOG4105DIA mandelate racemase muconate lactonizing WDLP6_RS27495 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) WDLP6_RS27515 ENOG4105ES5 Histidine kinase WDLP6_RS27525 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WDLP6_RS27535 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WDLP6_RS27540 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WDLP6_RS27545 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) WDLP6_RS27550 ENOG4108VZM 50s ribosomal protein L10 WDLP6_RS27555 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) WDLP6_RS27560 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) WDLP6_RS27570 ENOG4105PM1 preprotein translocase subunit SecE WDLP6_RS27580 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) WDLP6_RS27600 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) WDLP6_RS27605 ENOG4105DK0 Indole-3-glycerol phosphate synthase WDLP6_RS27610 ENOG4107QYG anthranilate phosphoribosyltransferase WDLP6_RS27620 ENOG4105DDQ anthranilate synthase WDLP6_RS27640 ENOG4105DTD Dehydrogenase WDLP6_RS27645 ENOG4105CHR reductase WDLP6_RS27650 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS27655 ENOG4108IV0 ABC, transporter WDLP6_RS27660 ENOG4105C0Z ABC transporter WDLP6_RS27665 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS27680 ENOG4105FUY alpha subunit WDLP6_RS27695 ENOG4105CHR reductase WDLP6_RS27700 ENOG4106IPI cyclase, family WDLP6_RS27710 ENOG4105CHU acetyl-coa acetyltransferase WDLP6_RS27715 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS27730 ENOG4105E3J oxidoreductase WDLP6_RS27760 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WDLP6_RS27770 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) WDLP6_RS27800 ENOG4105EUR Domain-Containing protein WDLP6_RS27800 ENOG4105EUR Domain-Containing protein WDLP6_RS27800 ENOG4105EUR Domain-Containing protein WDLP6_RS27805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WDLP6_RS27845 ENOG4108ZF3 Phosphatase WDLP6_RS27850 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) WDLP6_RS27870 ENOG4105EHI Phosphonate ABC transporter, periplasmic WDLP6_RS27875 ENOG4105EHI Phosphonate ABC transporter, periplasmic WDLP6_RS27880 ENOG4105BZU Histidine kinase WDLP6_RS27935 ENOG4105C75 arginyL-tRNA synthetase WDLP6_RS27950 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA WDLP6_RS27955 ENOG4108IUZ ABC transporter WDLP6_RS27960 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WDLP6_RS27965 ENOG4107RZC phospholipase d WDLP6_RS27975 ENOG4108YYC ycei family WDLP6_RS27980 ENOG4105DS1 cytochrome b561 WDLP6_RS27990 ENOG4105BZU Histidine kinase WDLP6_RS28000 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) WDLP6_RS28020 ENOG4105NVB glycoside hydrolase, family 19 WDLP6_RS28035 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving WDLP6_RS28060 ENOG4108ZAI phosphatidylglycerophosphatase a WDLP6_RS28075 ENOG4105WH1 Two component transcriptional regulator luxr family WDLP6_RS28080 ENOG4105BZU Histidine kinase WDLP6_RS28095 ENOG4108IMY Transcriptional regulator WDLP6_RS28100 ENOG4107W7X Aldolase WDLP6_RS28105 ENOG4105CH5 extracellular solute-binding protein, family 7 WDLP6_RS28125 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) WDLP6_RS28130 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) WDLP6_RS28140 ENOG4105NWN ApaG protein WDLP6_RS28145 ENOG4105DJV ribulose-phosphate 3-epimerase WDLP6_RS28155 ENOG4105DQE DNA ligase WDLP6_RS28175 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WDLP6_RS28195 ENOG4105ETE Transcriptional regulator (LacI family WDLP6_RS28235 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS28240 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase WDLP6_RS28265 ENOG4107QP3 malate synthase g WDLP6_RS28320 ENOG4107R15 K00850 6-phosphofructokinase 1 EC 2.7.1.11 WDLP6_RS28335 ENOG4105C0R drug resistance transporter emrb qaca subfamily WDLP6_RS28340 ENOG4105E7A Glutamine amidotransferase WDLP6_RS28360 ENOG4105D7Z glutathione synthase WDLP6_RS28365 ENOG4105DKK Benzoate WDLP6_RS28370 ENOG4105DFH Transport of potassium into the cell (By similarity) WDLP6_RS28380 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) WDLP6_RS28395 ENOG4105C8T Leucyl-tRNA synthetase WDLP6_RS28400 ENOG4105SG9 biopolymer transport protein, ExbD WDLP6_RS28410 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) WDLP6_RS28415 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) WDLP6_RS28420 ENOG41090R7 Ferric uptake WDLP6_RS28425 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) WDLP6_RS28430 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN WDLP6_RS28435 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA WDLP6_RS28440 ENOG4105C4R Atp-dependent dna helicase WDLP6_RS28445 ENOG4107QUT magnesium and cobalt transport protein CorA WDLP6_RS28450 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS28455 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WDLP6_RS28460 ENOG4105W8H transhydrogenase (subunit alpha WDLP6_RS28465 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WDLP6_RS28470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WDLP6_RS28485 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) WDLP6_RS28495 ENOG4105DEN Luciferase family WDLP6_RS28515 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WDLP6_RS28520 ENOG4107WZ3 Transferase WDLP6_RS28525 ENOG4105D3Q Sugar transferase WDLP6_RS28530 ENOG4105CGN Glycosyl transferase (Group 1 WDLP6_RS28535 ENOG4108PQP glycosyl transferase group 1 WDLP6_RS28550 ENOG4108MX3 Polysaccharide Biosynthesis Protein WDLP6_RS28555 ENOG4108IAJ Nad-dependent epimerase dehydratase WDLP6_RS28560 ENOG4107QQG Dehydrogenase WDLP6_RS28580 ENOG4108UUM single-stranded DNA-binding protein WDLP6_RS28585 ENOG4105CMQ Chloride channel WDLP6_RS28595 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WDLP6_RS28605 ENOG4105C29 acyl-CoA thioesterase WDLP6_RS28630 ENOG4105MSY salicylate hydroxylase WDLP6_RS28645 ENOG4108KB2 LysR family Transcriptional regulator WDLP6_RS28655 ENOG4105BZU Histidine kinase WDLP6_RS28665 ENOG4105ETX regulatoR WDLP6_RS28680 ENOG4105ERH Fumarylacetoacetate hydrolase WDLP6_RS28685 ENOG4105F1J Homogentisate 1,2-dioxygenase WDLP6_RS28695 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase WDLP6_RS28730 ENOG4105SKN orotidine 5''-phosphate decarboxylase WDLP6_RS28740 ENOG4105KEG ribosomal-protein-alanine acetyltransferase WDLP6_RS28745 ENOG41072GX Peptidase M22 Glycoprotease WDLP6_RS28760 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WDLP6_RS28765 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit WDLP6_RS28770 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) WDLP6_RS28775 ENOG4107QR8 Thioredoxin WDLP6_RS28785 ENOG4107RYR Transcriptional regulator, Crp Fnr family WDLP6_RS28795 ENOG4105C8V SAICAR synthetase WDLP6_RS28805 ENOG4105CA9 Pyruvate kinase WDLP6_RS28810 ENOG4105BZA Phosphoglycerate kinase WDLP6_RS28815 ENOG4105F04 LysR family Transcriptional regulator WDLP6_RS28830 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase WDLP6_RS28850 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) WDLP6_RS28870 ENOG4105C79 DNA protecting protein DprA WDLP6_RS28875 ENOG4108RPN Protein smg homolog WDLP6_RS28885 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WDLP6_RS28890 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WDLP6_RS28895 ENOG4105VIE preprotein translocase, subunit YajC WDLP6_RS28905 ENOG4108YXU transcriptional regulator AsnC family WDLP6_RS28910 ENOG4107SFI Major Facilitator superfamily WDLP6_RS28960 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) WDLP6_RS28965 ENOG4105FB2 class II Aldolase WDLP6_RS28970 ENOG4105G63 Type III effector Hrp-dependent WDLP6_RS28975 ENOG4105ZXK Dehydrogenase WDLP6_RS28985 ENOG4105C1J atp-dependent rna helicase WDLP6_RS28990 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) WDLP6_RS28995 ENOG4105C0H protease WDLP6_RS29005 ENOG4108Z86 Glutamine amidotransferase WDLP6_RS29015 ENOG4105C9U ATP-dependent DNA helicase RecQ WDLP6_RS29025 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase WDLP6_RS29055 ENOG4105DHQ Histidine kinase WDLP6_RS29070 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) WDLP6_RS29075 ENOG4108004 Modulates RecA activity (By similarity) WDLP6_RS29080 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase WDLP6_RS29085 ENOG4105CMV Succinyl-CoA synthetase subunit beta WDLP6_RS29090 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha WDLP6_RS29095 ENOG4108ZCF integral membrane protein WDLP6_RS29100 ENOG4108ZF3 Phosphatase WDLP6_RS29110 ENOG4105F8J Adenylate Guanylate cyclase WDLP6_RS29120 ENOG4105KHS type IV fimbrial pilin protein WDLP6_RS29160 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WDLP6_RS29165 ENOG4105ERG peptidase m48, ste24p WDLP6_RS29170 ENOG41086DT Membrane protein of unknown function WDLP6_RS29180 ENOG4108ZCF integral membrane protein WDLP6_RS29195 ENOG4108VWS Yaeq family WDLP6_RS29200 ENOG4107QTF adenylosuccinate lyase WDLP6_RS29210 ENOG4108M3P Membrane WDLP6_RS29215 ENOG4108U78 Glutathione S-transferase WDLP6_RS29230 ENOG4108KPJ rna polymerase sigma factor WDLP6_RS29235 ENOG4105K6T rare lipoprotein A WDLP6_RS29240 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) WDLP6_RS29255 ENOG4105BZU Histidine kinase WDLP6_RS29260 ENOG4108ZXC Two component transcriptional regulator, luxr family WDLP6_RS29285 ENOG4108YXU transcriptional regulator AsnC family WDLP6_RS29290 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) WDLP6_RS29295 ENOG4108RZE Tetr family transcriptional regulator WDLP6_RS29300 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase WDLP6_RS29345 ENOG4105CEV competence damage-inducible protein WDLP6_RS29350 ENOG4105CYX Short-chain dehydrogenase reductase Sdr WDLP6_RS29365 ENOG4107GJV short-chain dehydrogenase reductase WDLP6_RS29370 ENOG4107JEE Short-chain dehydrogenase reductase Sdr WDLP6_RS29375 ENOG4108YZY peptidylprolyl cis-trans isomerase WDLP6_RS29390 ENOG4105EUB pirin domain protein WDLP6_RS29410 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase WDLP6_RS29420 ENOG4105ERH Fumarylacetoacetate hydrolase WDLP6_RS29425 ENOG4105CPC Aldo Keto reductase WDLP6_RS29445 ENOG4105BZ9 Cytochrome C oxidase, subunit I WDLP6_RS29450 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) WDLP6_RS29460 ENOG4108Q1J Extracellular solute-binding protein, family 3 WDLP6_RS29465 ENOG4105DZG Dehydrogenase WDLP6_RS29470 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) WDLP6_RS29490 ENOG4107S2Z UPF0761 membrane protein WDLP6_RS29500 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) WDLP6_RS29565 ENOG4105EQ1 Transcriptional regulator WDLP6_RS29570 ENOG4105CHJ isochorismatase hydrolase WDLP6_RS29575 ENOG4105EFZ amidohydrolase WDLP6_RS29600 ENOG4105EAM Na Pi-cotransporter WDLP6_RS29605 ENOG4105ETT transcriptional Regulator, LysR family WDLP6_RS29615 ENOG4105DAA L-lactate WDLP6_RS29620 ENOG4105CPN adenine deaminase WDLP6_RS29625 ENOG4105CYX Short-chain dehydrogenase reductase Sdr WDLP6_RS29645 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein WDLP6_RS29650 ENOG4105FAE von Willebrand factor, type A WDLP6_RS29660 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) WDLP6_RS29665 ENOG4108IV0 ABC, transporter WDLP6_RS29670 ENOG4105C0Z ABC transporter WDLP6_RS29675 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS29680 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS29690 ENOG4108WUH Transcriptional regulator, TetR family WDLP6_RS29710 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family WDLP6_RS29720 ENOG4105CR8 Transcriptional regulator WDLP6_RS29750 ENOG4105DND Transcriptional regulator WDLP6_RS29765 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F WDLP6_RS29780 ENOG4105C32 Amino acid ABC transporter (Permease) WDLP6_RS29785 ENOG4108IUZ ABC transporter WDLP6_RS29790 ENOG4108IV0 ABC, transporter WDLP6_RS29795 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) WDLP6_RS29810 ENOG4105WEF catalase WDLP6_RS29815 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WDLP6_RS29825 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WDLP6_RS29835 ENOG4105BZU Histidine kinase WDLP6_RS29880 ENOG4108IAJ Nad-dependent epimerase dehydratase WDLP6_RS29950 ENOG4105C9U ATP-dependent DNA helicase RecQ WDLP6_RS29970 ENOG4105HSS phospholipase C WDLP6_RS30045 ENOG4105CGF Aromatic amino acid aminotransferase WDLP6_RS30050 ENOG41061MV Arylsulfatase WDLP6_RS30060 ENOG4105DUM transcriptional regulator, lysR family WDLP6_RS30065 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WDLP6_RS30075 ENOG4105CNV Aldolase WDLP6_RS30085 ENOG4105ERH Fumarylacetoacetate hydrolase WDLP6_RS30095 ENOG4105KME endoribonuclease L-psp WDLP6_RS30105 ENOG4107XC4 flavin reductase domain protein, FMN-binding WDLP6_RS30150 ENOG4105C1G acyl-Coa dehydrogenase WDLP6_RS30155 ENOG4105CEY Amp-dependent synthetase and ligase WDLP6_RS30180 ENOG41067TZ transcriptional regulator, MarR family WDLP6_RS30185 ENOG4105CQB FAD linked oxidase domain protein WDLP6_RS30190 ENOG4105DRR Transcriptional regulator, GntR family WDLP6_RS30195 ENOG4105C5R Aminotransferase WDLP6_RS30215 ENOG4108VX5 3-methyladenine DNA glycosylase WDLP6_RS30250 ENOG4105DZR Type I site-specific deoxyribonuclease WDLP6_RS30270 ENOG4105FDP GntR family transcriptional regulator WDLP6_RS30275 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS30280 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WDLP6_RS30295 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase WDLP6_RS30300 ENOG4105CV1 Transketolase (EC 2.2.1.1) WDLP6_RS30305 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) WDLP6_RS30310 ENOG4108S0S Nucleotidyl transferase WDLP6_RS30335 ENOG4107RAQ aminopeptidase WDLP6_RS30375 ENOG4105C6K Malic enzyme WDLP6_RS30390 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) WDLP6_RS30395 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) WDLP6_RS30400 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) WDLP6_RS30405 ENOG4105EHM Aminoglycoside phosphotransferase WDLP6_RS30410 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) WDLP6_RS30425 ENOG4105DXI Major Facilitator superfamily WDLP6_RS30445 ENOG4105EYW Ion transport protein WDLP6_RS30450 ENOG4105DWV Homoserine O-trans-acetylase WDLP6_RS30455 ENOG4105DWV Homoserine O-trans-acetylase WDLP6_RS30465 ENOG4105VFU Rna-binding protein WDLP6_RS30470 ENOG4107FW0 short-chain dehydrogenase reductase WDLP6_RS30480 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase WDLP6_RS30485 ENOG4105C2X Arabinose 5-phosphate isomerase WDLP6_RS30505 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) WDLP6_RS30510 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins WDLP6_RS30515 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) WDLP6_RS30520 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) WDLP6_RS30530 ENOG4107SKI cobyrinic Acid a,c-diamide synthase WDLP6_RS30545 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) WDLP6_RS30610 ENOG4105JAB phenazine biosynthesis protein, phzf family WDLP6_RS30705 ENOG4105KDM Diguanylate cyclase with gaf sensor WDLP6_RS30740 ENOG4105D9P serine threonine protein kinase WDLP6_RS30825 ENOG4105F9F transposase WDLP6_RS30910 ENOG4108KQ5 Integrase catalytic subunit WDLP6_RS30955 ENOG4108C33 Resolvase WDLP6_RS30980 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) WDLP6_RS31030 ENOG4106IJN integrase catalytic domain-containing protein WDLP6_RS31135 ENOG4105W7K Transcriptional regulator WDLP6_RS31145 ENOG4105E5H Transposase WDLP6_RS31230 ENOG4105W5Q DNA repair protein (RadC WDLP6_RS31325 ENOG4106D0Q Type IV secretion system protein VirB2 WDLP6_RS31370 ENOG4105CMA conjugation trbi family protein WDLP6_RS31430 ENOG4105EFZ amidohydrolase WDLP6_RS31560 ENOG4105VT3 DNA binding domain protein, excisionase family