locus-tag class description G3W91_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G3W91_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G3W91_RS00015 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W91_RS00030 ENOG4107RN3 metallophosphoesterase G3W91_RS00040 ENOG41061N2 exported protein G3W91_RS00055 ENOG4107UXM Membrane G3W91_RS00060 ENOG4105DZQ phospholipase D Transphosphatidylase G3W91_RS00065 ENOG4105X23 Endonuclease Exonuclease phosphatase G3W91_RS00085 ENOG4105EUB pirin domain protein G3W91_RS00100 ENOG4105F38 ABC transporter, permease G3W91_RS00110 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3W91_RS00115 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase G3W91_RS00135 ENOG4105CT7 inner membrane cred family protein G3W91_RS00140 ENOG4108JQC penicillin-binding protein 1A G3W91_RS00145 ENOG4105EB3 Histidine kinase G3W91_RS00150 ENOG4105E3W Two component transcriptional regulator (Winged helix family G3W91_RS00165 ENOG410681U heavy metal transport detoxification protein G3W91_RS00175 ENOG4105ECM Sensor protein basS pmrB G3W91_RS00180 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3W91_RS00185 ENOG4105CBP Major Facilitator G3W91_RS00190 ENOG4108K3A Glutathione S-transferase G3W91_RS00205 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G3W91_RS00210 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G3W91_RS00220 ENOG4107QJE Chromosome Partitioning Protein G3W91_RS00230 ENOG4105FA0 parb-like partition protein G3W91_RS00240 ENOG4105CQB FAD linked oxidase domain protein G3W91_RS00245 ENOG4108WBT adenosyltransferase G3W91_RS00280 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) G3W91_RS00285 ENOG4107QMS site-determining protein G3W91_RS00290 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) G3W91_RS00300 ENOG4105C2W permease G3W91_RS00305 ENOG4105KA0 thioesterase Superfamily protein G3W91_RS00320 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G3W91_RS00325 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS00360 ENOG4105IKQ hydratase G3W91_RS00365 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W91_RS00370 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS00385 ENOG41069M3 Transcriptional regulator G3W91_RS00425 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme G3W91_RS00450 ENOG4105EVZ LysR family transcriptional regulator G3W91_RS00460 ENOG4105F8J Adenylate Guanylate cyclase G3W91_RS00470 ENOG4108Z9W Outer membrane porin G3W91_RS00480 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3W91_RS00495 ENOG4105E2B Taurine dioxygenase G3W91_RS00505 ENOG4105C2W permease G3W91_RS00525 ENOG4105ZIR glutaredoxin-like protein G3W91_RS00530 ENOG4105C3M thioredoxin reductase G3W91_RS00535 ENOG4106H3A restriction G3W91_RS00550 ENOG4108IV0 ABC, transporter G3W91_RS00555 ENOG4105C0Z ABC transporter G3W91_RS00565 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS00595 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G3W91_RS00650 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3W91_RS00655 ENOG4105BZU Histidine kinase G3W91_RS00680 ENOG4105DTD Dehydrogenase G3W91_RS00700 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G3W91_RS00720 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G3W91_RS00770 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3W91_RS00775 ENOG4105F38 ABC transporter, permease G3W91_RS00780 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component G3W91_RS00795 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) G3W91_RS00805 ENOG4107RUE extracellular solute-binding protein family 1 G3W91_RS00820 ENOG4105CI2 imidazolone-5-propionate hydrolase G3W91_RS00835 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS00845 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G3W91_RS00870 ENOG4107QZ7 Cellulose synthase catalytic subunit G3W91_RS00875 ENOG4107EEX Cellulose synthase regulator protein G3W91_RS00880 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) G3W91_RS00885 ENOG4105EJG cellulose synthase G3W91_RS00890 ENOG4105K4H Nlp p60 protein G3W91_RS00915 ENOG4105JSC dimethylmenaquinone methyltransferase G3W91_RS00925 ENOG4108KSA LysR family transcriptional regulator G3W91_RS00930 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G3W91_RS00940 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS00950 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W91_RS00970 ENOG4105DQE DNA ligase G3W91_RS00980 ENOG4105FDF Could be involved in DNA repair (By similarity) G3W91_RS01055 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G3W91_RS01065 ENOG4107RZC phospholipase d G3W91_RS01070 ENOG4105EYW Ion transport protein G3W91_RS01080 ENOG4105D78 K07001 NTE family protein G3W91_RS01090 ENOG4105KWG Pfam:DUF1696 G3W91_RS01095 ENOG4105GAK amidohydrolase 2 G3W91_RS01120 ENOG4105DC7 peptidase M24 G3W91_RS01150 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3W91_RS01155 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G3W91_RS01190 ENOG4105E2V Glycosyltransferase 36 G3W91_RS01215 ENOG4105ECQ AraC Family Transcriptional Regulator G3W91_RS01220 ENOG4105EMU Dehydrogenase G3W91_RS01230 ENOG4107R11 Transcriptional regulator G3W91_RS01240 ENOG4107RSM transcriptional regulator G3W91_RS01245 ENOG4108Z4U Ferredoxin G3W91_RS01265 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W91_RS01285 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G3W91_RS01300 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3W91_RS01305 ENOG41086DT Membrane protein of unknown function G3W91_RS01330 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G3W91_RS01335 ENOG4105D3R alkyl hydroperoxide reductase G3W91_RS01345 ENOG4105ETT transcriptional Regulator, LysR family G3W91_RS01350 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS01355 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS01375 ENOG4105EMU Dehydrogenase G3W91_RS01415 ENOG4105ETE Transcriptional regulator (LacI family G3W91_RS01425 ENOG4105D9P serine threonine protein kinase G3W91_RS01445 ENOG4106NZI LysR family Transcriptional regulator G3W91_RS01450 ENOG4105CSV Glutaminase G3W91_RS01465 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3W91_RS01480 ENOG4105FDP GntR family transcriptional regulator G3W91_RS01495 ENOG4105DGI Alkaline phosphatase G3W91_RS01515 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) G3W91_RS01520 ENOG4105C7B Threonine dehydratase G3W91_RS01525 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W91_RS01540 ENOG4105C9U ATP-dependent DNA helicase RecQ G3W91_RS01565 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3W91_RS01575 ENOG4105CZE histidine utilization repressor G3W91_RS01580 ENOG4105C84 Histidine ammonia-lyase G3W91_RS01580 ENOG4105C84 Histidine ammonia-lyase G3W91_RS01585 ENOG4105CGP Urocanate hydratase G3W91_RS01605 ENOG41090B9 response to stress G3W91_RS01610 ENOG4105CI2 imidazolone-5-propionate hydrolase G3W91_RS01640 ENOG4105C3R Methionine synthase G3W91_RS01650 ENOG4105F52 Transcriptional regulator G3W91_RS01660 ENOG4105C3R Methionine synthase G3W91_RS01665 ENOG41063ZV G3W91_RS01670 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 G3W91_RS01680 ENOG4105IDI abc transporter atp-binding protein G3W91_RS01690 ENOG4108W9H Tetr family transcriptional regulator G3W91_RS01695 ENOG4105DP0 ferredoxin-NADP reductase G3W91_RS01735 ENOG4105C0Z ABC transporter G3W91_RS01740 ENOG4108IV0 ABC, transporter G3W91_RS01745 ENOG4108RWI nicotinamidase G3W91_RS01750 ENOG4108XHQ (2Fe-2S)-binding domain protein G3W91_RS01755 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G3W91_RS01785 ENOG4105C0P Mg chelatase subunit ChlI G3W91_RS01795 ENOG4108YZA Nitrogen regulatory protein pii G3W91_RS01800 ENOG4105BZU Histidine kinase G3W91_RS01810 ENOG4105EU8 FAD linked oxidase domain protein G3W91_RS01815 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G3W91_RS01830 ENOG4108V06 Glutathione peroxidase G3W91_RS01845 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G3W91_RS01855 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G3W91_RS01860 ENOG4105MP9 class II Aldolase G3W91_RS01870 ENOG4105C01 Dihydroxy-acid dehydratase G3W91_RS01890 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase G3W91_RS01895 ENOG4105C26 Dehydrogenase G3W91_RS01915 ENOG4108V8F Transcriptional regulator, MarR family G3W91_RS01920 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G3W91_RS01930 ENOG4105DH7 May be involved in recombination (By similarity) G3W91_RS01935 ENOG4105CM2 brancheD-chain amino acid aminotransferase G3W91_RS01955 ENOG4105E0F Histidine kinase G3W91_RS01960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W91_RS01965 ENOG4105D5U fad dependent oxidoreductase G3W91_RS01975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G3W91_RS01990 ENOG4105EYM Major Facilitator superfamily G3W91_RS01995 ENOG4105D0M Protease HtpX homolog G3W91_RS02000 ENOG4105EMU Dehydrogenase G3W91_RS02005 ENOG4105EQ1 Transcriptional regulator G3W91_RS02010 ENOG4105CHJ isochorismatase hydrolase G3W91_RS02020 ENOG4105EFZ amidohydrolase G3W91_RS02040 ENOG4105GVF (ABC) transporter G3W91_RS02045 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3W91_RS02085 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) G3W91_RS02090 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G3W91_RS02095 ENOG4108JQ9 ABC transporter G3W91_RS02100 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G3W91_RS02115 ENOG41061H0 Monooxygenase G3W91_RS02120 ENOG4105F04 LysR family Transcriptional regulator G3W91_RS02125 ENOG4105CGK Exodeoxyribonuclease III G3W91_RS02130 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G3W91_RS02140 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G3W91_RS02145 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W91_RS02150 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G3W91_RS02170 ENOG4105CJN penicillin-binding protein G3W91_RS02185 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G3W91_RS02205 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein G3W91_RS02210 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G3W91_RS02230 ENOG4105CR8 Transcriptional regulator G3W91_RS02240 ENOG4105D7N magnesium and cobalt transport protein CorA G3W91_RS02245 ENOG4105D52 delta-aminolevulinic acid dehydratase G3W91_RS02250 ENOG4108YXA Membrane G3W91_RS02260 ENOG4105NZG Ferredoxin G3W91_RS02265 ENOG4105DHZ alpha beta G3W91_RS02270 ENOG4105DZ1 carboxypeptidase G3W91_RS02275 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G3W91_RS02280 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G3W91_RS02285 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G3W91_RS02290 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G3W91_RS02295 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) G3W91_RS02310 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G3W91_RS02315 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G3W91_RS02320 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G3W91_RS02325 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G3W91_RS02330 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G3W91_RS02335 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) G3W91_RS02340 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) G3W91_RS02345 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) G3W91_RS02350 ENOG41084PQ 50s ribosomal protein l29 G3W91_RS02355 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G3W91_RS02375 ENOG4105T86 cytochrome C G3W91_RS02380 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G3W91_RS02390 ENOG4105JHE Major Facilitator Superfamily G3W91_RS02400 ENOG41080Z8 PHOSPHOCARRIER protein G3W91_RS02405 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G3W91_RS02420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W91_RS02430 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G3W91_RS02450 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G3W91_RS02460 ENOG4105C9Q fumarate hydratase class II G3W91_RS02465 ENOG4105F4P )-transporter G3W91_RS02470 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS02475 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G3W91_RS02480 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G3W91_RS02485 ENOG4105F0I Aminotransferase G3W91_RS02495 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) G3W91_RS02500 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G3W91_RS02505 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G3W91_RS02510 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G3W91_RS02515 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G3W91_RS02520 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G3W91_RS02525 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G3W91_RS02530 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) G3W91_RS02540 ENOG4105C2J ABC transporter G3W91_RS02545 ENOG4105CNN ABC, transporter G3W91_RS02550 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G3W91_RS02555 ENOG4105CIB oxidoreductase Domain protein G3W91_RS02600 ENOG4107T0X DNA ligase G3W91_RS02605 ENOG4107T0X DNA ligase G3W91_RS02610 ENOG4107QRT dEAD DEAH box helicase G3W91_RS02665 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3W91_RS02670 ENOG4105BZS acriflavin resistance protein G3W91_RS02680 ENOG4108IG5 Transcriptional regulator G3W91_RS02735 ENOG4105D85 methylase G3W91_RS02920 ENOG4105CA9 Pyruvate kinase G3W91_RS02930 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W91_RS02935 ENOG41079KZ Major Facilitator Superfamily G3W91_RS02975 ENOG4105ECQ AraC Family Transcriptional Regulator G3W91_RS02980 ENOG4105CSH Transporter G3W91_RS02990 ENOG4108Z4U Ferredoxin G3W91_RS03000 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase G3W91_RS03010 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein G3W91_RS03015 ENOG4105FGE Short-chain dehydrogenase reductase Sdr G3W91_RS03025 ENOG4105C26 Dehydrogenase G3W91_RS03030 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator G3W91_RS03035 ENOG4105DFW ABC transporter G3W91_RS03045 ENOG4108HWW ABC transporter G3W91_RS03050 ENOG4105C2J ABC transporter G3W91_RS03055 ENOG4107R9N ABC transporter G3W91_RS03060 ENOG41062B0 ABC transporter, permease G3W91_RS03085 ENOG41082RQ UPF0102 protein G3W91_RS03090 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G3W91_RS03100 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W91_RS03105 ENOG4105CZX twitching motility protein G3W91_RS03110 ENOG4105CZX twitching motility protein G3W91_RS03115 ENOG4105DFA alanine racemase domain protein G3W91_RS03120 ENOG4105EW9 transcriptional regulator AsnC family G3W91_RS03125 ENOG4105C26 Dehydrogenase G3W91_RS03130 ENOG4105D82 Glutamate dehydrogenase G3W91_RS03165 ENOG4105S7S phosphonate abc transporter G3W91_RS03170 ENOG4105D5T phosphonate abc transporter G3W91_RS03175 ENOG4105EHI Phosphonate ABC transporter, periplasmic G3W91_RS03180 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G3W91_RS03190 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) G3W91_RS03235 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G3W91_RS03250 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS03255 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G3W91_RS03270 ENOG41067MG lrgb family G3W91_RS03275 ENOG4105VAW lrga family G3W91_RS03280 ENOG4105CQB FAD linked oxidase domain protein G3W91_RS03290 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G3W91_RS03325 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G3W91_RS03375 ENOG4105CH2 amidohydrolase G3W91_RS03390 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W91_RS03415 ENOG4105MH5 phosphoesterase PA-phosphatase related protein G3W91_RS03445 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) G3W91_RS03450 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G3W91_RS03455 ENOG4105CB5 ATP-dependent DNA helicase recG G3W91_RS03460 ENOG4105C5Q Transcriptional regulator G3W91_RS03470 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) G3W91_RS03475 ENOG4105II7 pyrroline-5-carboxylate reductase G3W91_RS03485 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) G3W91_RS03490 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) G3W91_RS03495 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits G3W91_RS03500 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G3W91_RS03505 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G3W91_RS03510 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G3W91_RS03515 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G3W91_RS03520 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G3W91_RS03525 ENOG4105VPB 50S ribosomal protein L30 G3W91_RS03530 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G3W91_RS03535 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G3W91_RS03540 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G3W91_RS03545 ENOG41067V7 50S ribosomal protein L36 G3W91_RS03550 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G3W91_RS03555 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G3W91_RS03560 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G3W91_RS03565 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G3W91_RS03570 ENOG4108ZT0 50S ribosomal protein l17 G3W91_RS03590 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS03595 ENOG4108UKI Enoyl-CoA hydratase G3W91_RS03610 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G3W91_RS03635 ENOG4105EJC lysr family transcriptional regulator G3W91_RS03640 ENOG4105F6U Short-chain dehydrogenase reductase Sdr G3W91_RS03650 ENOG4105CPP Dehydrogenase, E1 component G3W91_RS03655 ENOG4107RUY (E1 component), alpha subunit G3W91_RS03695 ENOG4105DFW ABC transporter G3W91_RS03700 ENOG4108HWW ABC transporter G3W91_RS03720 ENOG4107TTD cytosine deaminase G3W91_RS03725 ENOG4108Z0Z intracellular protease Pfpi family G3W91_RS03730 ENOG4105DZS Phenylacetate-CoA ligase G3W91_RS03735 ENOG4108IV0 ABC, transporter G3W91_RS03755 ENOG4105C0Z ABC transporter G3W91_RS03760 ENOG4108IQE Amp-dependent synthetase and ligase G3W91_RS03765 ENOG4105IJJ transcriptional regulator, crp fnr family G3W91_RS03775 ENOG410904N short-chain dehydrogenase reductase G3W91_RS03795 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3W91_RS03800 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3W91_RS03805 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G3W91_RS03810 ENOG4105C08 Histidine kinase G3W91_RS03815 ENOG4105EEX Two component transcriptional regulator (Winged helix family G3W91_RS03825 ENOG4105FE9 pseudouridine synthase G3W91_RS03830 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3W91_RS03835 ENOG4105DHQ Histidine kinase G3W91_RS03890 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G3W91_RS03895 ENOG4106A3M Cytochrome p-450 G3W91_RS03900 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS03910 ENOG4105CSU acyl-Coa dehydrogenase G3W91_RS03915 ENOG4106NZI LysR family Transcriptional regulator G3W91_RS03920 ENOG4105E27 serine threonine protein kinase G3W91_RS03930 ENOG4108ZHJ Organic hydroperoxide resistance protein G3W91_RS03935 ENOG4105K56 Transcriptional regulator G3W91_RS03945 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W91_RS03950 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR G3W91_RS03970 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS03980 ENOG4105C0Z ABC transporter G3W91_RS03985 ENOG4108IV0 ABC, transporter G3W91_RS04050 ENOG4107S78 Band 7 protein G3W91_RS04060 ENOG4105EQN UPF0261 protein G3W91_RS04065 ENOG4105C0Z ABC transporter G3W91_RS04085 ENOG4105CI2 imidazolone-5-propionate hydrolase G3W91_RS04090 ENOG4105CI2 imidazolone-5-propionate hydrolase G3W91_RS04095 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) G3W91_RS04100 ENOG4105ERH Fumarylacetoacetate hydrolase G3W91_RS04120 ENOG4105BZU Histidine kinase G3W91_RS04130 ENOG4108J2P Alpha beta hydrolase fold G3W91_RS04155 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS04165 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) G3W91_RS04170 ENOG4109066 lysm domain bon superfamily protein G3W91_RS04180 ENOG4105CH5 extracellular solute-binding protein, family 7 G3W91_RS04190 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS04190 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS04205 ENOG4105DC8 reductase G3W91_RS04220 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G3W91_RS04225 ENOG4105FYV Amp nucleosidase G3W91_RS04235 ENOG4108ZHR arsR family transcriptional regulator G3W91_RS04255 ENOG4105HEI LysR family (Transcriptional regulator G3W91_RS04260 ENOG4105CJ1 ABC, transporter G3W91_RS04270 ENOG4106BRA Membrane G3W91_RS04275 ENOG4105CWC Acetylornithine deacetylase G3W91_RS04280 ENOG4105CH2 amidohydrolase G3W91_RS04295 ENOG4108J2R molybdopterin oxidoreductase G3W91_RS04300 ENOG41068KF Universal stress protein G3W91_RS04355 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase G3W91_RS04365 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase G3W91_RS04385 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G3W91_RS04405 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G3W91_RS04415 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G3W91_RS04420 ENOG4105C5E polysaccharide biosynthesis protein G3W91_RS04430 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G3W91_RS04455 ENOG4105J5G Transferase hexapeptide repeat containing protein G3W91_RS04485 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G3W91_RS04500 ENOG4105C0K Gdp-mannose 4,6-dehydratase G3W91_RS04515 ENOG4105C30 Nad-dependent epimerase dehydratase G3W91_RS04535 ENOG4105CJT Mannose-1-phosphate guanylyltransferase G3W91_RS04540 ENOG4105EXC Acyl-transferase G3W91_RS04550 ENOG4108SHN Glycosyl transferase, family 2 G3W91_RS04565 ENOG4105CAS nag kinase G3W91_RS04575 ENOG4105CMR udp-glucose 4-epimerase G3W91_RS04585 ENOG4105CH6 catalase G3W91_RS04605 ENOG410829K Lysine exporter protein (Lyse ygga) G3W91_RS04610 ENOG4105CHR reductase G3W91_RS04620 ENOG4105IPI Membrane G3W91_RS04635 ENOG4108ZCF integral membrane protein G3W91_RS04665 ENOG4105GAK amidohydrolase 2 G3W91_RS04675 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W91_RS04680 ENOG4105RQF LysR family Transcriptional regulator G3W91_RS04685 ENOG4105CD3 dihydroorotase G3W91_RS04695 ENOG4105CGP Urocanate hydratase G3W91_RS04715 ENOG4108T2C cysteine dioxygenase type I G3W91_RS04740 ENOG4107RN6 Monooxygenase G3W91_RS04745 ENOG4105YVM Phosphoesterase, PA-phosphatase related G3W91_RS04760 ENOG4105BZU Histidine kinase G3W91_RS04765 ENOG4105DG4 malate L-lactate dehydrogenase G3W91_RS04770 ENOG4105CTX dehydratase G3W91_RS04775 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS04785 ENOG4108ERU trap dicarboxylate transporter subunit DctP G3W91_RS04790 ENOG4107YCY Transcriptional regulator G3W91_RS04795 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G3W91_RS04800 ENOG4106517 Short-chain dehydrogenase reductase Sdr G3W91_RS04805 ENOG4105ERH Fumarylacetoacetate hydrolase G3W91_RS04810 ENOG4105C26 Dehydrogenase G3W91_RS04815 ENOG4105EXG Transcriptional regulator G3W91_RS04820 ENOG4105BZU Histidine kinase G3W91_RS04825 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W91_RS04845 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G3W91_RS04850 ENOG4106YN8 Prenyltransferase G3W91_RS04865 ENOG4105CSU acyl-Coa dehydrogenase G3W91_RS04880 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS04895 ENOG41060WC Enoyl-CoA hydratase G3W91_RS04900 ENOG4105EQR Transposase IS116 IS110 IS902 G3W91_RS04905 ENOG4105NAU thioesterase Superfamily protein G3W91_RS04910 ENOG4108JJ7 ABC transporter G3W91_RS04915 ENOG4105C5I Dehydrogenase G3W91_RS04925 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS04930 ENOG4105CNN ABC, transporter G3W91_RS04935 ENOG4105C0Z ABC transporter G3W91_RS04940 ENOG4108IV0 ABC, transporter G3W91_RS04950 ENOG4105RE0 Asp Glu hydantoin racemase G3W91_RS04965 ENOG4108UAU isochorismatase G3W91_RS04975 ENOG4107YNJ LysR family Transcriptional regulator G3W91_RS04980 ENOG4107RP9 extracellular solute-binding protein, family 3 G3W91_RS04985 ENOG4105EAD ABC transporter G3W91_RS04990 ENOG4105DRP amino acid AbC transporter G3W91_RS04995 ENOG4105CDA abc transporter atp-binding protein G3W91_RS05000 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W91_RS05005 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS05035 ENOG4105C5Q Transcriptional regulator G3W91_RS05050 ENOG4105EA8 2-Nitropropane dioxygenase G3W91_RS05060 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS05065 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS05070 ENOG4105CC9 acyl-Coa dehydrogenase G3W91_RS05075 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS05085 ENOG4105CBN LysR family transcriptional regulator G3W91_RS05090 ENOG4105E33 succinate dehydrogenase G3W91_RS05095 ENOG4105C8Q Methyl-accepting chemotaxis G3W91_RS05100 ENOG4105J0Q Transcriptional regulator G3W91_RS05105 ENOG4105E7W lamb ycsf family protein G3W91_RS05115 ENOG4105C6T cysteine synthase G3W91_RS05135 ENOG4105EKE dihydroorotase G3W91_RS05175 ENOG4107HP6 Transcriptional regulator G3W91_RS05180 ENOG4105D0M Protease HtpX homolog G3W91_RS05185 ENOG4105DZ0 fad dependent oxidoreductase G3W91_RS05200 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3W91_RS05210 ENOG4105FE9 pseudouridine synthase G3W91_RS05215 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G3W91_RS05225 ENOG4107R0V Pyruvate dehydrogenase G3W91_RS05230 ENOG4105CPP Dehydrogenase, E1 component G3W91_RS05235 ENOG4107QSN dihydrolipoamide acetyltransferase G3W91_RS05245 ENOG4107QX8 SPFH domain, Band 7 family protein G3W91_RS05250 ENOG4105D7N magnesium and cobalt transport protein CorA G3W91_RS05270 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS05295 ENOG4105E1J oxidoreductase G3W91_RS05305 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G3W91_RS05320 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3W91_RS05325 ENOG4105DR4 Methyltransferase G3W91_RS05330 ENOG4105CKI cobalamin synthesis protein G3W91_RS05345 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) G3W91_RS05350 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) G3W91_RS05355 ENOG4108V6E Cell division protein mraZ G3W91_RS05360 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) G3W91_RS05370 ENOG4105CJN penicillin-binding protein G3W91_RS05375 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G3W91_RS05380 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) G3W91_RS05385 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G3W91_RS05390 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G3W91_RS05395 ENOG4105CNI cell division protein FtsW G3W91_RS05400 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G3W91_RS05405 ENOG4105DFU Cell wall formation (By similarity) G3W91_RS05410 ENOG4105CPF Cell wall formation (By similarity) G3W91_RS05415 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) G3W91_RS05420 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G3W91_RS05425 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G3W91_RS05430 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3W91_RS05435 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G3W91_RS05450 ENOG4105K6V RNA polymerase G3W91_RS05470 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) G3W91_RS05475 ENOG4105KNE Phosphatidate cytidylyltransferase G3W91_RS05495 ENOG4105E2X shikimate dehydrogenase G3W91_RS05505 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) G3W91_RS05510 ENOG4105IPS esterase G3W91_RS05515 ENOG4105CNI cell division protein FtsW G3W91_RS05520 ENOG4105D1U peptidase U62 modulator of DNA gyrase G3W91_RS05525 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G3W91_RS05535 ENOG4105DFU Cell wall formation (By similarity) G3W91_RS05545 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G3W91_RS05550 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G3W91_RS05555 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G3W91_RS05560 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G3W91_RS05570 ENOG4107T4Z adenosine kinase G3W91_RS05580 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3W91_RS05585 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3W91_RS05595 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W91_RS05600 ENOG4107TUY Histidine kinase G3W91_RS05615 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G3W91_RS05620 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) G3W91_RS05630 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W91_RS05640 ENOG4107WP9 Histidine kinase G3W91_RS05645 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G3W91_RS05655 ENOG4105ENT Efflux transporter rnd family, mfp subunit G3W91_RS05660 ENOG4105BZS acriflavin resistance protein G3W91_RS05705 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) G3W91_RS05715 ENOG4105FGE Short-chain dehydrogenase reductase Sdr G3W91_RS05730 ENOG4105M0Y G3W91_RS05755 ENOG4105CHR reductase G3W91_RS05760 ENOG4105CBN LysR family transcriptional regulator G3W91_RS05775 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase G3W91_RS05780 ENOG4105BZP glycoside hydrolase 15-related G3W91_RS05785 ENOG4108K4C ec 3.1.3.12 G3W91_RS05790 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G3W91_RS05800 ENOG4108302 MgtC SapB transporter G3W91_RS05805 ENOG4105E4C Lytic transglycosylase catalytic G3W91_RS05810 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G3W91_RS05815 ENOG4105ETT transcriptional Regulator, LysR family G3W91_RS05830 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G3W91_RS05850 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G3W91_RS05855 ENOG4105F7P transcriptional regulator AsnC family G3W91_RS05870 ENOG4105FDP GntR family transcriptional regulator G3W91_RS05920 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS05955 ENOG4105C7F AcnD-accessory protein PrpF G3W91_RS05960 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS05985 ENOG4105CD5 CoA-binding domain protein G3W91_RS05995 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS06000 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS06005 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS06045 ENOG4105DU1 integral membrane protein, terc G3W91_RS06085 ENOG4108MN8 Membrane G3W91_RS06095 ENOG41063Z6 transcriptional regulator, lysR family G3W91_RS06100 ENOG4105CHM Aminotransferase G3W91_RS06110 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3W91_RS06120 ENOG4105SB3 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G3W91_RS06140 ENOG4105CHM Aminotransferase G3W91_RS06145 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W91_RS06150 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i G3W91_RS06160 ENOG41067HZ cytochrome C, class I G3W91_RS06200 ENOG4107GFK fumarate G3W91_RS06230 ENOG4105DC8 reductase G3W91_RS06235 ENOG4108Z9W Outer membrane porin G3W91_RS06240 ENOG4105MSY salicylate hydroxylase G3W91_RS06255 ENOG4105VSH 4-oxalocrotonate tautomerase G3W91_RS06270 ENOG4108K2P TRANSCRIPTIONal G3W91_RS06330 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W91_RS06335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W91_RS06350 ENOG4105K63 Thioredoxin G3W91_RS06370 ENOG4105C3M thioredoxin reductase G3W91_RS06375 ENOG4105D0M Protease HtpX homolog G3W91_RS06380 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W91_RS06385 ENOG4105ECQ AraC Family Transcriptional Regulator G3W91_RS06390 ENOG4105K3G Periplasmic Protein G3W91_RS06400 ENOG4105VN1 Heat shock protein G3W91_RS06410 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3W91_RS06415 ENOG4105BZU Histidine kinase G3W91_RS06420 ENOG4105DRR Transcriptional regulator, GntR family G3W91_RS06435 ENOG4105CTX dehydratase G3W91_RS06440 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS06445 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter G3W91_RS06455 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W91_RS06475 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS06480 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS06490 ENOG4105ETT transcriptional Regulator, LysR family G3W91_RS06500 ENOG4105CV8 reductase G3W91_RS06505 ENOG4105F27 Major Facilitator G3W91_RS06510 ENOG4105HEI LysR family (Transcriptional regulator G3W91_RS06540 ENOG4108IG5 Transcriptional regulator G3W91_RS06545 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G3W91_RS06585 ENOG4105C0H protease G3W91_RS06595 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G3W91_RS06640 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i G3W91_RS06675 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G3W91_RS06680 ENOG4105D4P Coproporphyrinogen iii oxidase G3W91_RS06690 ENOG4105CD5 CoA-binding domain protein G3W91_RS06695 ENOG4105CY0 Metallo-Beta-Lactamase G3W91_RS06700 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) G3W91_RS06705 ENOG4105DBV ornithine carbamoyltransferase G3W91_RS06710 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G3W91_RS06720 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G3W91_RS06730 ENOG4105EAQ (twin-arginine translocation) pathway signal G3W91_RS06765 ENOG4105CHR reductase G3W91_RS06775 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class G3W91_RS06785 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G3W91_RS06795 ENOG41080TK Universal stress protein G3W91_RS06815 ENOG4107QRI Phosphoketolase G3W91_RS06830 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS06835 ENOG4105ERH Fumarylacetoacetate hydrolase G3W91_RS06895 ENOG4105CC0 LysR family Transcriptional regulator G3W91_RS06905 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase G3W91_RS06910 ENOG4105CS1 NAD(P)H quinone oxidoreductase G3W91_RS06930 ENOG4105EUF amidase EC 3.5.1.4 G3W91_RS06945 ENOG4105CMT Dihydroxyacetone kinase G3W91_RS06955 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3W91_RS06965 ENOG4105CF7 AraC family transcriptional regulator G3W91_RS06995 ENOG4108MJI response regulator G3W91_RS07050 ENOG4105DS1 cytochrome b561 G3W91_RS07055 ENOG4105EQ0 Major Facilitator superfamily G3W91_RS07060 ENOG4105HEI LysR family (Transcriptional regulator G3W91_RS07070 ENOG4105F4K antigen 43 G3W91_RS07075 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) G3W91_RS07080 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G3W91_RS07095 ENOG4105CG3 alpha amylase, catalytic region G3W91_RS07100 ENOG4107S9Q Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) G3W91_RS07105 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G3W91_RS07145 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3W91_RS07175 ENOG4105BZ1 (ABC) transporter G3W91_RS07185 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G3W91_RS07190 ENOG4105CQ0 ABC transporter G3W91_RS07200 ENOG4105D7Q type ii secretion system G3W91_RS07210 ENOG4107QHF type ii secretion system protein e G3W91_RS07250 ENOG4108VAU general secretion pathway protein G G3W91_RS07260 ENOG4105C7B Threonine dehydratase G3W91_RS07265 ENOG4108UKZ OsmC family G3W91_RS07270 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) G3W91_RS07275 ENOG4108Z9W Outer membrane porin G3W91_RS07280 ENOG4105DEF Extracellular solute-binding protein, family 5 G3W91_RS07290 ENOG4105CH2 amidohydrolase G3W91_RS07295 ENOG4108J59 Extracellular solute-binding protein, family 5 G3W91_RS07300 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W91_RS07305 ENOG4105C3U ABC transporter G3W91_RS07310 ENOG4108JQ7 (ABC) transporter G3W91_RS07315 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G3W91_RS07330 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G3W91_RS07335 ENOG4107QP8 phosphohexose isomerase G3W91_RS07340 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G3W91_RS07355 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G3W91_RS07360 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) G3W91_RS07370 ENOG4105FP9 thiamine pyrophosphate G3W91_RS07380 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS07395 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G3W91_RS07440 ENOG4105R0I Feruloyl esterase G3W91_RS07460 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS07465 ENOG4108JQ1 Dehydrogenase G3W91_RS07470 ENOG4105JSC dimethylmenaquinone methyltransferase G3W91_RS07515 ENOG4105CHB tonB-dependent Receptor G3W91_RS07525 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G3W91_RS07535 ENOG4105D1S lipid A biosynthesis G3W91_RS07540 ENOG4105D74 hydrolase G3W91_RS07545 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) G3W91_RS07550 ENOG4106RE7 Cytochrome G3W91_RS07560 ENOG4105CRE cytochrome C G3W91_RS07565 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G3W91_RS07570 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) G3W91_RS07575 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G3W91_RS07580 ENOG4105XQ6 frataxin-like protein G3W91_RS07585 ENOG4108JQC penicillin-binding protein 1A G3W91_RS07610 ENOG4105E4G Type IV pilus G3W91_RS07615 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G3W91_RS07625 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein G3W91_RS07660 ENOG4105DHJ ABC, transporter G3W91_RS07665 ENOG4105CY3 ABC transporter, permease G3W91_RS07670 ENOG4107PE3 Mammalian cell entry related domain protein G3W91_RS07690 ENOG4105DA5 (ABC) transporter G3W91_RS07695 ENOG4105E3A (ABC) transporter G3W91_RS07700 ENOG4105VFK BolA family G3W91_RS07705 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G3W91_RS07710 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G3W91_RS07725 ENOG4105CIH Imidazole acetol-phosphate transaminase G3W91_RS07730 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G3W91_RS07740 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G3W91_RS07745 ENOG4105F4K antigen 43 G3W91_RS07750 ENOG4105DSB aldose 1-epimerase G3W91_RS07755 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G3W91_RS07760 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G3W91_RS07765 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase G3W91_RS07775 ENOG4107YU2 histidine triad (hIT) protein G3W91_RS07780 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G3W91_RS07785 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G3W91_RS07790 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G3W91_RS07795 ENOG4105C0H protease G3W91_RS07800 ENOG4107QNR UPF0135 protein G3W91_RS07805 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G3W91_RS07810 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G3W91_RS07815 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G3W91_RS07820 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G3W91_RS07825 ENOG4105EIX cytochrome c1 G3W91_RS07830 ENOG4107MKT Stringent starvation protein a G3W91_RS07835 ENOG4105KB2 stringent starvation protein b G3W91_RS07845 ENOG4108UAU isochorismatase G3W91_RS07860 ENOG4105RE0 Asp Glu hydantoin racemase G3W91_RS07900 ENOG4105CH5 extracellular solute-binding protein, family 7 G3W91_RS07910 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS07930 ENOG4107Z6I Thiamine biosynthesis protein G3W91_RS07940 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W91_RS07980 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G3W91_RS07995 ENOG4105M6F mutator MutT protein G3W91_RS08000 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) G3W91_RS08015 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein G3W91_RS08035 ENOG4107QHF type ii secretion system protein e G3W91_RS08045 ENOG4108KMV Glycosyl transferase (Group 1 G3W91_RS08065 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G3W91_RS08085 ENOG4105C6Y Udp-glucose 6-dehydrogenase G3W91_RS08095 ENOG4106WTF Glycosyl transferase, family 2 G3W91_RS08100 ENOG4105CH7 arginosuccinase G3W91_RS08105 ENOG4108HRK Histidine kinase G3W91_RS08110 ENOG4108NEV two component transcriptional regulator, LytTR family G3W91_RS08115 ENOG4105DSF transport protein G3W91_RS08130 ENOG4105CSH Transporter G3W91_RS08145 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) G3W91_RS08165 ENOG4105DIA mandelate racemase muconate lactonizing G3W91_RS08180 ENOG4105HSS phospholipase C G3W91_RS08195 ENOG4105D5T phosphonate abc transporter G3W91_RS08210 ENOG4106KNT transcriptional regulator G3W91_RS08220 ENOG4105C26 Dehydrogenase G3W91_RS08235 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS08240 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter G3W91_RS08245 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W91_RS08255 ENOG4105CTX dehydratase G3W91_RS08260 ENOG4105CXK mandelate racemase muconate lactonizing G3W91_RS08265 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G3W91_RS08305 ENOG4105HSS phospholipase C G3W91_RS08310 ENOG4106KNT transcriptional regulator G3W91_RS08315 ENOG4105BZ4 penicillin-binding protein G3W91_RS08325 ENOG4105KA0 thioesterase Superfamily protein G3W91_RS08360 ENOG4105NI8 Cytosine-specific methyltransferase G3W91_RS08365 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G3W91_RS08370 ENOG4105DZR Type I site-specific deoxyribonuclease G3W91_RS08380 ENOG4107QTH restriction modification system DNA specificity domain G3W91_RS08385 ENOG4105CVR type I restriction-modification system G3W91_RS08435 ENOG4105EAH synthase G3W91_RS08440 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) G3W91_RS08445 ENOG4105K46 50S ribosomal protein l27 G3W91_RS08450 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G3W91_RS08455 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G3W91_RS08465 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) G3W91_RS08470 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G3W91_RS08475 ENOG4105E4C Lytic transglycosylase catalytic G3W91_RS08480 ENOG4105C37 (CBS) domain G3W91_RS08485 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G3W91_RS08500 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G3W91_RS08505 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G3W91_RS08510 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G3W91_RS08520 ENOG4105EGS Mechanosensitive ion channel G3W91_RS08525 ENOG4107T6V glycerophosphoryl diester phosphodiesterase G3W91_RS08530 ENOG4108IJ9 (ABC) transporter G3W91_RS08540 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component G3W91_RS08550 ENOG4108JQ1 Dehydrogenase G3W91_RS08570 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3W91_RS08585 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) G3W91_RS08590 ENOG4108IA2 Sodium pantothenate symporter G3W91_RS08605 ENOG4105C9M aspartyl-trna synthetase G3W91_RS08615 ENOG4105X23 Endonuclease Exonuclease phosphatase G3W91_RS08620 ENOG4105EUJ GTP cyclohydrolase i G3W91_RS08660 ENOG4106H29 UPF0391 membrane protein G3W91_RS08665 ENOG4105BZU Histidine kinase G3W91_RS08670 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS08685 ENOG41066T0 asmA family G3W91_RS08690 ENOG4105D06 uba thif-type nad fad binding protein G3W91_RS08695 ENOG4105CN1 protease G3W91_RS08700 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G3W91_RS08705 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) G3W91_RS08710 ENOG4105VW4 glutaredoxin 3 G3W91_RS08715 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) G3W91_RS08720 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G3W91_RS08725 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G3W91_RS08730 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G3W91_RS08740 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase G3W91_RS08745 ENOG4107RJX Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G3W91_RS08750 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G3W91_RS08755 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) G3W91_RS08760 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) G3W91_RS08765 ENOG4108IYU L-aspartate oxidase G3W91_RS08785 ENOG4105CHH sulfate transporter G3W91_RS08795 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G3W91_RS08800 ENOG4108YXG UPF0502 protein G3W91_RS08810 ENOG4105C5Q Transcriptional regulator G3W91_RS08825 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G3W91_RS08855 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G3W91_RS08860 ENOG4105QAX Iron-sulfur G3W91_RS08885 ENOG4105CV6 ABC transporter, permease G3W91_RS08895 ENOG4105C28 cystathionine G3W91_RS08905 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G3W91_RS08910 ENOG4108RAC Rubrerythrin G3W91_RS08945 ENOG4105W5Q DNA repair protein (RadC G3W91_RS08950 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase G3W91_RS08955 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G3W91_RS08960 ENOG4105C7B Threonine dehydratase G3W91_RS08970 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G3W91_RS09015 ENOG4105H3G oxidoreductase G3W91_RS09025 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G3W91_RS09055 ENOG4107SQD Transcriptional regulator, GntR family G3W91_RS09060 ENOG4105CHR reductase G3W91_RS09065 ENOG4105CJW magnesium transporter G3W91_RS09075 ENOG4105C7I Dehydrogenase G3W91_RS09085 ENOG4105BZU Histidine kinase G3W91_RS09095 ENOG4105C31 Tryptophanyl-tRNA synthetase G3W91_RS09100 ENOG4108Z4T Peptidase M50 G3W91_RS09105 ENOG4107RTD sua5 ycio yrdc ywlc family protein G3W91_RS09115 ENOG4105DB7 PHP domain protein G3W91_RS09125 ENOG4105CSR polyphosphate kinase 2 G3W91_RS09140 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein G3W91_RS09145 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS09155 ENOG4105C0Z ABC transporter G3W91_RS09160 ENOG4108IV0 ABC, transporter G3W91_RS09175 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS09195 ENOG4105CDA abc transporter atp-binding protein G3W91_RS09200 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G3W91_RS09210 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3W91_RS09220 ENOG4105E5Q amino acid AbC transporter G3W91_RS09235 ENOG41079KZ Major Facilitator Superfamily G3W91_RS09240 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G3W91_RS09245 ENOG4108Z6B deaminase G3W91_RS09260 ENOG4105CC9 acyl-Coa dehydrogenase G3W91_RS09270 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS09275 ENOG4108UKI Enoyl-CoA hydratase G3W91_RS09285 ENOG4108UKI Enoyl-CoA hydratase G3W91_RS09290 ENOG4108WYP Transcriptional regulator G3W91_RS09295 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS09300 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS09305 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W91_RS09310 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS09350 ENOG4105C0Z ABC transporter G3W91_RS09355 ENOG4108IV0 ABC, transporter G3W91_RS09360 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS09365 ENOG4105CC9 acyl-Coa dehydrogenase G3W91_RS09370 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS09415 ENOG4105EYW Ion transport protein G3W91_RS09425 ENOG4105CS1 NAD(P)H quinone oxidoreductase G3W91_RS09430 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold G3W91_RS09440 ENOG4105BZU Histidine kinase G3W91_RS09445 ENOG4108TJN glycosyl transferase group 1 G3W91_RS09490 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3W91_RS09525 ENOG4105E6M Sulphatase-modifying factor protein G3W91_RS09550 ENOG4105EAM Na Pi-cotransporter G3W91_RS09565 ENOG4105ETT transcriptional Regulator, LysR family G3W91_RS09585 ENOG4107UXM Membrane G3W91_RS09605 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W91_RS09610 ENOG4105D7T ABC transporter G3W91_RS09635 ENOG4105C6K Malic enzyme G3W91_RS09665 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G3W91_RS09675 ENOG4107E2E PKHD-type hydroxylase G3W91_RS09715 ENOG4105CMJ mandelate racemase muconate lactonizing G3W91_RS09720 ENOG4107YNJ LysR family Transcriptional regulator G3W91_RS09725 ENOG4105BZU Histidine kinase G3W91_RS09745 ENOG4105EIG urea carboxylase-associated protein 1 G3W91_RS09770 ENOG4105DEN Luciferase family G3W91_RS09780 ENOG4105CMD Transcriptional regulator, GntR family G3W91_RS09790 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS09795 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS09825 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS09830 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS09880 ENOG410811B TRANSCRIPTIONal G3W91_RS09890 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3W91_RS09895 ENOG4108JQ7 (ABC) transporter G3W91_RS09905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W91_RS09925 ENOG4108MP6 LysR family Transcriptional regulator G3W91_RS09950 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W91_RS09960 ENOG4106FTQ Taurine ABC transporter, periplasmic G3W91_RS09970 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W91_RS09975 ENOG4105CYM Glutathione S-transferase G3W91_RS09980 ENOG4105CSH Transporter G3W91_RS09990 ENOG4108FUF Transcriptional regulator, IclR family G3W91_RS10015 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS10020 ENOG4105CD5 CoA-binding domain protein G3W91_RS10060 ENOG4105HEI LysR family (Transcriptional regulator G3W91_RS10070 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS10075 ENOG4108EKI Dehydrogenase G3W91_RS10160 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS10165 ENOG4105ENE Histidine kinase G3W91_RS10180 ENOG4108FUF Transcriptional regulator, IclR family G3W91_RS10195 ENOG4105DUM transcriptional regulator, lysR family G3W91_RS10200 ENOG4105DB1 molybdopterin oxidoreductase G3W91_RS10205 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G3W91_RS10210 ENOG4108KDI dmso reductase anchor subunit G3W91_RS10230 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3W91_RS10235 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G3W91_RS10250 ENOG4107RZC phospholipase d G3W91_RS10280 ENOG41082BM Transcriptional regulator, arsr family G3W91_RS10285 ENOG4105HSS phospholipase C G3W91_RS10295 ENOG4105BZU Histidine kinase G3W91_RS10300 ENOG4107QVM von Willebrand factor, type A G3W91_RS10320 ENOG4105EJC lysr family transcriptional regulator G3W91_RS10330 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W91_RS10355 ENOG4108ZC9 flagellar basal-body rod protein flgc G3W91_RS10360 ENOG4105W00 Flagellar hook capping protein G3W91_RS10365 ENOG4105BZE flagellar hook protein, FlgE G3W91_RS10370 ENOG4108KPB Flagellar basal-body rod protein FlgF G3W91_RS10375 ENOG4105CGA flagellar basal-body rod protein FlgG G3W91_RS10380 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) G3W91_RS10390 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj G3W91_RS10395 ENOG4108V3W Chemotaxis protein, CheW G3W91_RS10400 ENOG4105C8Q Methyl-accepting chemotaxis G3W91_RS10405 ENOG4108V3W Chemotaxis protein, CheW G3W91_RS10410 ENOG4105C8Q Methyl-accepting chemotaxis G3W91_RS10415 ENOG4105C8Q Methyl-accepting chemotaxis G3W91_RS10420 ENOG4105C8Q Methyl-accepting chemotaxis G3W91_RS10425 ENOG4105E1Q flagellar hook-associated protein G3W91_RS10430 ENOG4105DTJ flagellar hook-associated protein G3W91_RS10440 ENOG4108SVW integral membrane protein G3W91_RS10445 ENOG4106HB6 Alpha beta hydrolase G3W91_RS10480 ENOG4105E0F Histidine kinase G3W91_RS10495 ENOG4105EXG Transcriptional regulator G3W91_RS10500 ENOG4105CHR reductase G3W91_RS10510 ENOG4108ZHJ Organic hydroperoxide resistance protein G3W91_RS10520 ENOG4105ETT transcriptional Regulator, LysR family G3W91_RS10525 ENOG410846T CoA-transferase family III G3W91_RS10540 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS10550 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS10565 ENOG4105Z4T Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) G3W91_RS10570 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3W91_RS10580 ENOG4105CCU oxidase (Subunit III) G3W91_RS10605 ENOG4105D19 Role in flagellar biosynthesis (By similarity) G3W91_RS10610 ENOG4105VS8 Flagellar biosynthetic protein fliq G3W91_RS10615 ENOG4105CN7 Flagellar biosynthetic protein FliP G3W91_RS10625 ENOG4105DD5 Flagellar motor switch protein G3W91_RS10630 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G3W91_RS10635 ENOG4107ZI8 flagellar basal body-associated protein flil G3W91_RS10640 ENOG4105WF4 Flagellar hook-length control protein G3W91_RS10645 ENOG4105GSA Flagellar export protein flij G3W91_RS10650 ENOG4108JIR Flagellum-specific ATP synthase G3W91_RS10655 ENOG4108CG0 Flagellar assembly protein G3W91_RS10660 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G3W91_RS10665 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) G3W91_RS10675 ENOG4105I03 Flagellin G3W91_RS10680 ENOG41063QE flagellar protein FlaG G3W91_RS10685 ENOG4105DTS flagellar hook-associated G3W91_RS10690 ENOG4105MQ3 flagellar protein FliS G3W91_RS10705 ENOG4105D00 flagellar biosynthetic protein flhB G3W91_RS10715 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region G3W91_RS10720 ENOG4107RD7 Flagellar Motor Protein, MotA G3W91_RS10725 ENOG4105ER2 Ompa motb domain protein G3W91_RS10730 ENOG4105CBS Chea signal transduction histidine kinase G3W91_RS10735 ENOG4105D58 Diguanylate phosphodiesterase G3W91_RS10740 ENOG4105BZU Histidine kinase G3W91_RS10755 ENOG4108VYJ response regulator receiver protein G3W91_RS10760 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) G3W91_RS10785 ENOG4105D00 flagellar biosynthetic protein flhB G3W91_RS10790 ENOG4105D7B Flagellar biosynthesis protein flha G3W91_RS10795 ENOG4105FZW flagellar biosynthesis regulator FlhF G3W91_RS10805 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W91_RS10820 ENOG4105TV9 FHA Domain-Containing protein G3W91_RS10850 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 G3W91_RS10855 ENOG4105CD8 aminopeptidase N G3W91_RS10865 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G3W91_RS10870 ENOG4105CPC Aldo Keto reductase G3W91_RS10875 ENOG4108Z66 YbaK ebsC protein G3W91_RS10880 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) G3W91_RS10885 ENOG4105M4H endoribonuclease L-psp G3W91_RS10895 ENOG4108VPT UPF0234 protein G3W91_RS10900 ENOG4105D4A Cell wall formation (By similarity) G3W91_RS10905 ENOG4105CDH Citrulline--aspartate ligase G3W91_RS10910 ENOG4105NBK UPF0345 protein G3W91_RS10920 ENOG4105KUZ arsenate reductase G3W91_RS10925 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G3W91_RS10940 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase G3W91_RS10945 ENOG4105C28 cystathionine G3W91_RS10950 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G3W91_RS10975 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS10980 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS10990 ENOG410811B TRANSCRIPTIONal G3W91_RS10995 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G3W91_RS11015 ENOG4105C7W Xanthine dehydrogenase G3W91_RS11025 ENOG4105C7N Xanthine uracil vitamin C permease G3W91_RS11030 ENOG4108JQ9 ABC transporter G3W91_RS11035 ENOG4105UIB (ABC) transporter G3W91_RS11055 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3W91_RS11070 ENOG4105BZU Histidine kinase G3W91_RS11075 ENOG4107QHF type ii secretion system protein e G3W91_RS11080 ENOG4105BZU Histidine kinase G3W91_RS11100 ENOG4108TJN glycosyl transferase group 1 G3W91_RS11105 ENOG4107QUY Guanine deaminase G3W91_RS11110 ENOG4105DHP deoxycytidine triphosphate deaminase G3W91_RS11115 ENOG4105CGZ zinc metallopeptidase G3W91_RS11120 ENOG4105C1J atp-dependent rna helicase G3W91_RS11125 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) G3W91_RS11130 ENOG4105EE5 Membrane protein terC G3W91_RS11170 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W91_RS11175 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3W91_RS11180 ENOG41060W2 glyoxylate carboligase G3W91_RS11185 ENOG4105CC0 LysR family Transcriptional regulator G3W91_RS11190 ENOG4105C8Q Methyl-accepting chemotaxis G3W91_RS11240 ENOG4107YCY Transcriptional regulator G3W91_RS11245 ENOG4105CK2 sodium dicarboxylate symporter G3W91_RS11305 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme G3W91_RS11310 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G3W91_RS11335 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS11345 ENOG4105CYM Glutathione S-transferase G3W91_RS11350 ENOG4108K3A Glutathione S-transferase G3W91_RS11355 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3W91_RS11365 ENOG4105CBN LysR family transcriptional regulator G3W91_RS11370 ENOG4105ENT Efflux transporter rnd family, mfp subunit G3W91_RS11380 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3W91_RS11410 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS11420 ENOG4105CH5 extracellular solute-binding protein, family 7 G3W91_RS11450 ENOG4105CHR reductase G3W91_RS11460 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS11465 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS11480 ENOG4105DWV Homoserine O-trans-acetylase G3W91_RS11485 ENOG4105CXK mandelate racemase muconate lactonizing G3W91_RS11490 ENOG4105C5I Dehydrogenase G3W91_RS11495 ENOG4105CXK mandelate racemase muconate lactonizing G3W91_RS11505 ENOG4105CZE histidine utilization repressor G3W91_RS11510 ENOG4105EXG Transcriptional regulator G3W91_RS11520 ENOG4105CJP fad dependent oxidoreductase G3W91_RS11530 ENOG4105CH2 amidohydrolase G3W91_RS11535 ENOG4108RYR transcriptional regulator AsnC family G3W91_RS11565 ENOG4105CJP fad dependent oxidoreductase G3W91_RS11570 ENOG4108J59 Extracellular solute-binding protein, family 5 G3W91_RS11580 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W91_RS11590 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3W91_RS11595 ENOG4105C26 Dehydrogenase G3W91_RS11600 ENOG4108DN8 FAD dependent oxidoreductase G3W91_RS11610 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS11615 ENOG4105CBG Sulfatase G3W91_RS11620 ENOG4105DDW LysR family Transcriptional regulator G3W91_RS11625 ENOG4105CQB FAD linked oxidase domain protein G3W91_RS11645 ENOG4108M9J MaoC like domain protein G3W91_RS11655 ENOG4105CI0 Citrate lyase G3W91_RS11660 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G3W91_RS11665 ENOG4105F04 LysR family Transcriptional regulator G3W91_RS11675 ENOG4105C7F AcnD-accessory protein PrpF G3W91_RS11680 ENOG4108Z9W Outer membrane porin G3W91_RS11685 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W91_RS11690 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS11695 ENOG4105ETE Transcriptional regulator (LacI family G3W91_RS11705 ENOG4105GAK amidohydrolase 2 G3W91_RS11710 ENOG4105C0H protease G3W91_RS11715 ENOG4108YV4 Universal stress protein G3W91_RS11750 ENOG4107Y70 Heat shock protein G3W91_RS11760 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W91_RS11765 ENOG4105C0H protease G3W91_RS11780 ENOG41080TK Universal stress protein G3W91_RS11795 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3W91_RS11835 ENOG4107RZC phospholipase d G3W91_RS11840 ENOG4107RCI amp-dependent synthetase and ligase G3W91_RS11860 ENOG4108JYK Dehydrogenase G3W91_RS11865 ENOG4105CPP Dehydrogenase, E1 component G3W91_RS11875 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G3W91_RS11880 ENOG4105TMB Formate nitrite transporter G3W91_RS11890 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS11895 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G3W91_RS11905 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) G3W91_RS11915 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G3W91_RS11960 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3W91_RS11965 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G3W91_RS11975 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3W91_RS11980 ENOG4105DHQ Histidine kinase G3W91_RS12000 ENOG4108IQE Amp-dependent synthetase and ligase G3W91_RS12015 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3W91_RS12020 ENOG4105D60 lipoprotein releasing system transmembrane protein G3W91_RS12030 ENOG4108IRC dna polymerase iii G3W91_RS12035 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G3W91_RS12055 ENOG4107QN1 sodium solute G3W91_RS12060 ENOG41062QD Membrane G3W91_RS12090 ENOG4105BZU Histidine kinase G3W91_RS12095 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS12110 ENOG4105CRU nitrate reductase, alpha subunit G3W91_RS12115 ENOG4108IUE nitrate reductase beta subunit G3W91_RS12120 ENOG4105R3A Nitrate reductase G3W91_RS12125 ENOG4105D0D Nitrate reductase 2, gamma subunit G3W91_RS12130 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G3W91_RS12160 ENOG41080TK Universal stress protein G3W91_RS12225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W91_RS12235 ENOG4105BZU Histidine kinase G3W91_RS12270 ENOG4105C7W Xanthine dehydrogenase G3W91_RS12275 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding G3W91_RS12280 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit G3W91_RS12285 ENOG4105ECQ AraC Family Transcriptional Regulator G3W91_RS12290 ENOG4105F27 Major Facilitator G3W91_RS12300 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3W91_RS12315 ENOG4105EJC lysr family transcriptional regulator G3W91_RS12380 ENOG4105CV8 reductase G3W91_RS12385 ENOG4105C2W permease G3W91_RS12410 ENOG4107QN2 dihydrolipoyl dehydrogenase G3W91_RS12420 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein G3W91_RS12425 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G3W91_RS12440 ENOG4107YCY Transcriptional regulator G3W91_RS12480 ENOG4105CJ1 ABC, transporter G3W91_RS12485 ENOG4107QWP ABC-2 type transporter G3W91_RS12490 ENOG4107QWP ABC-2 type transporter G3W91_RS12525 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein G3W91_RS12560 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS12565 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W91_RS12570 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase G3W91_RS12585 ENOG4105R0I Feruloyl esterase G3W91_RS12625 ENOG4105DKB L-sorbosone dehydrogenase G3W91_RS12645 ENOG4105D9P serine threonine protein kinase G3W91_RS12685 ENOG4105CDV Ompa motb domain protein G3W91_RS12735 ENOG4105EMN RNA polymerase sigma factor G3W91_RS12760 ENOG4105C59 p-type ATPase G3W91_RS12770 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G3W91_RS12785 ENOG4107RT3 EamA-like transporter family G3W91_RS12800 ENOG4107QKV phosphomannomutase G3W91_RS12805 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase G3W91_RS12835 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G3W91_RS12850 ENOG4105YA8 Transcriptional regulator G3W91_RS12855 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G3W91_RS12870 ENOG4105CPF Cell wall formation (By similarity) G3W91_RS12875 ENOG4105CFH Aspartokinase G3W91_RS12880 ENOG4105CPC Aldo Keto reductase G3W91_RS12890 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G3W91_RS12915 ENOG4105C01 Dihydroxy-acid dehydratase G3W91_RS12920 ENOG4108UHU Aldolase G3W91_RS12930 ENOG4108UYE Lactoylglutathione lyase G3W91_RS12935 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3W91_RS12950 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS12955 ENOG4105EA8 2-Nitropropane dioxygenase G3W91_RS12960 ENOG4107GJV short-chain dehydrogenase reductase G3W91_RS12970 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS12975 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS12980 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G3W91_RS12985 ENOG4105CHR reductase G3W91_RS13000 ENOG4105DIQ Transcriptional regulator G3W91_RS13025 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W91_RS13030 ENOG4105D7K pfkb domain protein G3W91_RS13080 ENOG4108RTU Aldolase G3W91_RS13090 ENOG4105C01 Dihydroxy-acid dehydratase G3W91_RS13095 ENOG4105C5I Dehydrogenase G3W91_RS13100 ENOG4107EJG GntR family transcriptional regulator G3W91_RS13110 ENOG4105D56 permease protein G3W91_RS13125 ENOG4105C1J atp-dependent rna helicase G3W91_RS13135 ENOG4105C5H ABC transporter G3W91_RS13140 ENOG4105D8V Glucose sorbosone dehydrogenase G3W91_RS13150 ENOG4108KX4 response regulator G3W91_RS13165 ENOG4105KXX peptidase s58 dmpa G3W91_RS13175 ENOG4105W1Y Transcriptional regulator G3W91_RS13180 ENOG4107VXM glycerophosphoryl diester phosphodiesterase G3W91_RS13195 ENOG4105E5Q amino acid AbC transporter G3W91_RS13200 ENOG4105DRP amino acid AbC transporter G3W91_RS13205 ENOG4107RP9 extracellular solute-binding protein, family 3 G3W91_RS13215 ENOG4108Z9K Osmotically inducible protein G3W91_RS13220 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS13245 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase G3W91_RS13260 ENOG41067HS methyltransferase G3W91_RS13275 ENOG41081QV Universal stress protein G3W91_RS13280 ENOG4105D3G Pseudouridine synthase G3W91_RS13300 ENOG4105CKW Inner membrane protein yedI G3W91_RS13305 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) G3W91_RS13315 ENOG4105F4K antigen 43 G3W91_RS13330 ENOG4106CJB Phospholipase Carboxylesterase G3W91_RS13335 ENOG4105D9M gamma-glutamylcysteine synthetase G3W91_RS13340 ENOG4107QWB Ornithine cyclodeaminase G3W91_RS13345 ENOG4108UYB regulatoR G3W91_RS13355 ENOG4105VUF Transcriptional regulator G3W91_RS13360 ENOG4105F0I Aminotransferase G3W91_RS13370 ENOG4108VAC response regulator G3W91_RS13375 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) G3W91_RS13440 ENOG4107XZC Restriction modification system DNA (Specificity G3W91_RS13455 ENOG4105CX6 glutaminyL-tRNA synthetase G3W91_RS13465 ENOG4108VAC response regulator G3W91_RS13470 ENOG4108HRK Histidine kinase G3W91_RS13500 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3W91_RS13515 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G3W91_RS13540 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) G3W91_RS13550 ENOG41061MV Arylsulfatase G3W91_RS13555 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS13565 ENOG4108VHT MarR family transcriptional regulator G3W91_RS13575 ENOG4105DDW LysR family Transcriptional regulator G3W91_RS13590 ENOG4105ECY inositol monophosphatase G3W91_RS13600 ENOG4105D7W serine acetyltransferase G3W91_RS13605 ENOG4108RIR Molybdenum cofactor biosynthesis protein G3W91_RS13615 ENOG4105CMS peptidase U62, modulator of DNA gyrase G3W91_RS13625 ENOG4105VCC 30S ribosomal protein S21 G3W91_RS13630 ENOG4105CBX hi0933 family G3W91_RS13640 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G3W91_RS13645 ENOG4108MTB glycosyl transferase family G3W91_RS13660 ENOG4108IFG nitrite reductase, (NAD(P)H) G3W91_RS13680 ENOG4105D7T ABC transporter G3W91_RS13690 ENOG4105I5W Transporter G3W91_RS13700 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G3W91_RS13710 ENOG4107Y70 Heat shock protein G3W91_RS13715 ENOG4105ES9 amino acid G3W91_RS13725 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G3W91_RS13730 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G3W91_RS13740 ENOG4105CP7 Triose-phosphate isomerase G3W91_RS13745 ENOG4107EJC Preprotein translocase subunit SecG G3W91_RS13755 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G3W91_RS13760 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W91_RS13765 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G3W91_RS13770 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W91_RS13775 ENOG4105GKE subunit e G3W91_RS13780 ENOG4107QIZ NADH dehydrogenase G3W91_RS13790 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) G3W91_RS13795 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W91_RS13800 ENOG4105DF2 NADH dehydrogenase subunit j G3W91_RS13805 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W91_RS13815 ENOG4105C8S subunit m G3W91_RS13820 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G3W91_RS13830 ENOG4108YZ4 nudix hydrolase G3W91_RS13840 ENOG4105BZ1 (ABC) transporter G3W91_RS13845 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G3W91_RS13855 ENOG4105CW7 secretion protein, HlyD family G3W91_RS13860 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3W91_RS13865 ENOG4105C0Z ABC transporter G3W91_RS13870 ENOG4108IV0 ABC, transporter G3W91_RS13885 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS13915 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W91_RS13925 ENOG4105CSH Transporter G3W91_RS13935 ENOG4108SHN Glycosyl transferase, family 2 G3W91_RS13965 ENOG4105DIJ Phosphoethanolamine transferase G3W91_RS13975 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W91_RS13980 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS13985 ENOG4105CGP Urocanate hydratase G3W91_RS14000 ENOG4105C5Q Transcriptional regulator G3W91_RS14010 ENOG4107REC cytoplasmic protein G3W91_RS14015 ENOG4108IV0 ABC, transporter G3W91_RS14020 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G3W91_RS14025 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS14050 ENOG4105JXH GntR family transcriptional regulator G3W91_RS14060 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS14065 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS14070 ENOG4105EXG Transcriptional regulator G3W91_RS14075 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3W91_RS14080 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G3W91_RS14085 ENOG4105C2C drug resistance transporter, Bcr CflA G3W91_RS14095 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G3W91_RS14100 ENOG4105DQR SNARE associated Golgi G3W91_RS14115 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G3W91_RS14120 ENOG4105K8N protein family UPF0079, ATPase G3W91_RS14125 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G3W91_RS14145 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3W91_RS14180 ENOG4105ED9 Protein of unknown function (DUF455) G3W91_RS14185 ENOG4108Z0R Transferase G3W91_RS14190 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) G3W91_RS14205 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G3W91_RS14210 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G3W91_RS14220 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase G3W91_RS14225 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G3W91_RS14230 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G3W91_RS14240 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G3W91_RS14255 ENOG4108YZY peptidylprolyl cis-trans isomerase G3W91_RS14260 ENOG4105EZE Cupin 4 family protein G3W91_RS14275 ENOG4105Q2H domain protein G3W91_RS14280 ENOG4105GJM (LipO)protein G3W91_RS14285 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3W91_RS14300 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W91_RS14310 ENOG4105EMN RNA polymerase sigma factor G3W91_RS14315 ENOG4105E4C Lytic transglycosylase catalytic G3W91_RS14330 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W91_RS14355 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G3W91_RS14365 ENOG4105E5Q amino acid AbC transporter G3W91_RS14370 ENOG4105E5Q amino acid AbC transporter G3W91_RS14375 ENOG4105EAB amino acid AbC transporter G3W91_RS14380 ENOG4105CDA abc transporter atp-binding protein G3W91_RS14390 ENOG4105D7K pfkb domain protein G3W91_RS14395 ENOG4105C5I Dehydrogenase G3W91_RS14400 ENOG4108M60 Transcriptional regulator G3W91_RS14420 ENOG4105C26 Dehydrogenase G3W91_RS14425 ENOG4108UYU AsnC family transcriptional regulator G3W91_RS14450 ENOG4108EC8 DNA internalization-related competence protein ComEC G3W91_RS14465 ENOG4108JJA ABC, transporter G3W91_RS14470 ENOG4105C42 Type I secretion membrane fusion protein (HlyD G3W91_RS14485 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G3W91_RS14490 ENOG4105E98 transcriptional regulator DeoR family G3W91_RS14495 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G3W91_RS14505 ENOG4108IJ9 (ABC) transporter G3W91_RS14515 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component G3W91_RS14540 ENOG4105CVE Lytic murein transglycosylase G3W91_RS14545 ENOG4105F8C transglutaminase domain-containing protein G3W91_RS14555 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G3W91_RS14560 ENOG4105DGU Histone deacetylase G3W91_RS14565 ENOG4105EGS Mechanosensitive ion channel G3W91_RS14570 ENOG4105BZJ Electron transfer flavoprotein G3W91_RS14575 ENOG4105C10 Electron transfer flavoprotein G3W91_RS14580 ENOG4105CSU acyl-Coa dehydrogenase G3W91_RS14600 ENOG4108JJ9 ABC, transporter G3W91_RS14605 ENOG4108JJ8 (ABC) transporter G3W91_RS14610 ENOG4105C4M (Ubiquinol oxidase) subunit I G3W91_RS14615 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G3W91_RS14625 ENOG4105BZU Histidine kinase G3W91_RS14655 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G3W91_RS14665 ENOG4105CSH Transporter G3W91_RS14680 ENOG4107HP6 Transcriptional regulator G3W91_RS14685 ENOG4105E2X shikimate dehydrogenase G3W91_RS14695 ENOG4105E2X shikimate dehydrogenase G3W91_RS14700 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G3W91_RS14735 ENOG4105EGI Transcriptional regulator G3W91_RS14740 ENOG4105CBP Major Facilitator G3W91_RS14755 ENOG4105CHP RNA polymerase G3W91_RS14760 ENOG4105GRZ Ycii-related protein G3W91_RS14775 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G3W91_RS14785 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G3W91_RS14790 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G3W91_RS14795 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G3W91_RS14805 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS14815 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W91_RS14820 ENOG4105EXW epimerase dehydratase G3W91_RS14825 ENOG4105BZU Histidine kinase G3W91_RS14830 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G3W91_RS14835 ENOG4105CHR reductase G3W91_RS14855 ENOG4105DHQ Histidine kinase G3W91_RS14870 ENOG4105DIJ Phosphoethanolamine transferase G3W91_RS14880 ENOG4107FQ9 ethanolamine ammonia-lyase G3W91_RS14885 ENOG4105CPD ethanolamine ammonia-lyase G3W91_RS14890 ENOG4108V1T peptidylprolyl cis-trans isomerase G3W91_RS14905 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G3W91_RS14915 ENOG4105CF1 Alkylated DNA repair protein G3W91_RS14925 ENOG4108KX4 response regulator G3W91_RS14940 ENOG410846T CoA-transferase family III G3W91_RS14960 ENOG4105C26 Dehydrogenase G3W91_RS14970 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS14975 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W91_RS14980 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W91_RS15005 ENOG4105CVJ phosphoglycerate mutase G3W91_RS15010 ENOG41061ZR Transcriptional regulator G3W91_RS15015 ENOG4106S2D Transcriptional regulator G3W91_RS15030 ENOG4107RZC phospholipase d G3W91_RS15035 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G3W91_RS15040 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G3W91_RS15050 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W91_RS15055 ENOG4105BZ1 (ABC) transporter G3W91_RS15060 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G3W91_RS15225 ENOG4105C0B DNA polymerase III (alpha subunit) G3W91_RS15235 ENOG4105CP9 extracellular ligand-binding receptor G3W91_RS15245 ENOG4108W9H Tetr family transcriptional regulator G3W91_RS15270 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3W91_RS15275 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) G3W91_RS15290 ENOG4105NXH GreA GreB family elongation factor G3W91_RS15295 ENOG4107QZF nitrite reductase NADPH large subunit G3W91_RS15300 ENOG4105WZK nitrite reductase NADPH small subunit G3W91_RS15305 ENOG4105TMB Formate nitrite transporter G3W91_RS15310 ENOG4107QPV Serine Threonine protein kinase G3W91_RS15320 ENOG4105D82 Glutamate dehydrogenase G3W91_RS15345 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G3W91_RS15355 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W91_RS15360 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) G3W91_RS15390 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G3W91_RS15395 ENOG4107HP6 Transcriptional regulator G3W91_RS15405 ENOG4105C7K acetolactate synthase G3W91_RS15410 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) G3W91_RS15430 ENOG4105MSY salicylate hydroxylase G3W91_RS15450 ENOG4108Z9W Outer membrane porin G3W91_RS15485 ENOG4105MP9 class II Aldolase G3W91_RS15490 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G3W91_RS15505 ENOG4105F8V Hydrolase, tatD family G3W91_RS15515 ENOG4107QRG dna polymerase iii G3W91_RS15520 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G3W91_RS15525 ENOG4105HHA aminodeoxychorismate lyase G3W91_RS15530 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G3W91_RS15535 ENOG4105VCD cytoplasmic protein G3W91_RS15540 ENOG4105D22 carbon starvation protein G3W91_RS15570 ENOG4105C0A alcohol dehydrogenase G3W91_RS15590 ENOG4105C5I Dehydrogenase G3W91_RS15600 ENOG4105ETT transcriptional Regulator, LysR family G3W91_RS15640 ENOG4105BZM domain protein G3W91_RS15670 ENOG4105EJC lysr family transcriptional regulator G3W91_RS15695 ENOG4107QJQ Mate efflux family protein G3W91_RS15720 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G3W91_RS15740 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3W91_RS15745 ENOG4105C2C drug resistance transporter, Bcr CflA G3W91_RS15785 ENOG4105DY2 Paraquat-inducible protein b G3W91_RS15790 ENOG4105F1S paraquat-inducible protein a G3W91_RS15795 ENOG4105F1S paraquat-inducible protein a G3W91_RS15800 ENOG4105HEI LysR family (Transcriptional regulator G3W91_RS15805 ENOG4105F27 Major Facilitator G3W91_RS15810 ENOG4105CPC Aldo Keto reductase G3W91_RS15815 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3W91_RS15820 ENOG4105DHQ Histidine kinase G3W91_RS15830 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G3W91_RS15840 ENOG4105KCV RNA signal recognition particle 4.5S RNA G3W91_RS15860 ENOG4105CSU acyl-Coa dehydrogenase G3W91_RS15865 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G3W91_RS15875 ENOG4105CHR reductase G3W91_RS15885 ENOG4105CSU acyl-Coa dehydrogenase G3W91_RS15890 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS15895 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G3W91_RS15900 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W91_RS15905 ENOG4108IV0 ABC, transporter G3W91_RS15910 ENOG4105C0Z ABC transporter G3W91_RS15920 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS15930 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS15935 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G3W91_RS15940 ENOG4105CNG UPF0061 protein G3W91_RS15945 ENOG4105E0X reductase G3W91_RS15950 ENOG4107835 probably involved in intracellular septation (By similarity) G3W91_RS15960 ENOG4107TF3 peptidylprolyl cis-trans isomerase G3W91_RS15980 ENOG4108ETH Formylglycinamide ribotide synthetase G3W91_RS15985 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G3W91_RS15990 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G3W91_RS15995 ENOG4105MGM doxx family G3W91_RS16000 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G3W91_RS16010 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G3W91_RS16020 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G3W91_RS16065 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) G3W91_RS16070 ENOG4108IJ6 ABC transporter G3W91_RS16075 ENOG4105ECW sulfate abc transporter G3W91_RS16080 ENOG4108I5D sulfate abc transporter G3W91_RS16085 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G3W91_RS16095 ENOG4105JQN Transcriptional regulator G3W91_RS16100 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G3W91_RS16120 ENOG4105D7W serine acetyltransferase G3W91_RS16125 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G3W91_RS16130 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) G3W91_RS16135 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) G3W91_RS16150 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) G3W91_RS16160 ENOG4108UT2 hemolysin iii G3W91_RS16190 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) G3W91_RS16195 ENOG4105C11 sulfate adenylyltransferase), subunit 2 G3W91_RS16200 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) G3W91_RS16205 ENOG4108Z4U Ferredoxin G3W91_RS16210 ENOG4105CAY ferredoxin--nadp reductase G3W91_RS16215 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G3W91_RS16225 ENOG4105W2Z cytochrome C, class I G3W91_RS16235 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3W91_RS16240 ENOG4108TEB UPF0114 protein G3W91_RS16250 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G3W91_RS16255 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit G3W91_RS16265 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS16315 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G3W91_RS16320 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G3W91_RS16325 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G3W91_RS16330 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G3W91_RS16345 ENOG4105ENT Efflux transporter rnd family, mfp subunit G3W91_RS16400 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant G3W91_RS16405 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G3W91_RS16430 ENOG4108IV0 ABC, transporter G3W91_RS16435 ENOG4105C0Z ABC transporter G3W91_RS16460 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS16545 ENOG4105CC0 LysR family Transcriptional regulator G3W91_RS16555 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS16565 ENOG4105CC9 acyl-Coa dehydrogenase G3W91_RS16575 ENOG4105CHR reductase G3W91_RS16590 ENOG4105EN6 Membrane G3W91_RS16595 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G3W91_RS16625 ENOG4105DHQ Histidine kinase G3W91_RS16630 ENOG4105VEJ Heat shock protein G3W91_RS16635 ENOG4105CSR polyphosphate kinase 2 G3W91_RS16645 ENOG4107HP6 Transcriptional regulator G3W91_RS16685 ENOG4105CFH Aspartokinase G3W91_RS16690 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G3W91_RS16695 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) G3W91_RS16705 ENOG4105C8N cysteinyl-tRNA synthetase G3W91_RS16725 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) G3W91_RS16730 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) G3W91_RS16745 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division G3W91_RS16750 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G3W91_RS16755 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) G3W91_RS16780 ENOG4106855 Competence protein G3W91_RS16785 ENOG4106855 Competence protein G3W91_RS16790 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G3W91_RS16795 ENOG4108R6K riboflavin synthase, subunit alpha G3W91_RS16800 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G3W91_RS16805 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G3W91_RS16810 ENOG4107YIM Involved in the transcription termination process (By similarity) G3W91_RS16815 ENOG4105CHM Aminotransferase G3W91_RS16820 ENOG4107YD3 Thioesterase G3W91_RS16825 ENOG4105E02 MotA TolQ exbB proton channel G3W91_RS16830 ENOG4108ZZF transport protein (ExbD) G3W91_RS16840 ENOG4105C0B DNA polymerase III (alpha subunit) G3W91_RS16845 ENOG4105C72 UPF0176 protein G3W91_RS16850 ENOG4105EUB pirin domain protein G3W91_RS16860 ENOG4108VBZ doxx family G3W91_RS16880 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G3W91_RS16885 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G3W91_RS16900 ENOG4105FDF Could be involved in DNA repair (By similarity) G3W91_RS16915 ENOG4105DV0 amidase (EC 3.5.1.4 G3W91_RS16930 ENOG4105MP9 class II Aldolase G3W91_RS16960 ENOG4105CBG Sulfatase G3W91_RS16965 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS16970 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS16975 ENOG4105C8Q Methyl-accepting chemotaxis G3W91_RS17000 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G3W91_RS17005 ENOG4108Z6B deaminase G3W91_RS17025 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W91_RS17030 ENOG4105BZU Histidine kinase G3W91_RS17035 ENOG4107QK4 glycoside hydrolase, family 3 domain protein G3W91_RS17050 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G3W91_RS17055 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme G3W91_RS17060 ENOG4108IV0 ABC, transporter G3W91_RS17065 ENOG4105C0Z ABC transporter G3W91_RS17075 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS17085 ENOG4105CHR reductase G3W91_RS17095 ENOG4105EBR Carboxylesterase G3W91_RS17105 ENOG4105EQ2 LysR family Transcriptional regulator G3W91_RS17110 ENOG4105CD5 CoA-binding domain protein G3W91_RS17115 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS17130 ENOG4105CSH Transporter G3W91_RS17135 ENOG4105E2S oxidase) subunit II G3W91_RS17140 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3W91_RS17145 ENOG4105CCU oxidase (Subunit III) G3W91_RS17150 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) G3W91_RS17160 ENOG4105TX3 Histidine kinase G3W91_RS17165 ENOG4108UYB regulatoR G3W91_RS17170 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G3W91_RS17185 ENOG4107SM8 Adenylate Guanylate cyclase G3W91_RS17195 ENOG410846T CoA-transferase family III G3W91_RS17200 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS17210 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G3W91_RS17215 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G3W91_RS17230 ENOG4108Z1B Cyclase dehydrase G3W91_RS17235 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G3W91_RS17270 ENOG4105CI3 gtp-binding protein typa G3W91_RS17275 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G3W91_RS17280 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) G3W91_RS17290 ENOG4105CHV Transcription elongation factor NusA G3W91_RS17295 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) G3W91_RS17300 ENOG4105CBP Major Facilitator G3W91_RS17305 ENOG4108JQ5 ABC transporter G3W91_RS17310 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component G3W91_RS17315 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component G3W91_RS17320 ENOG4105E43 Extracellular solute-binding protein, family 5 G3W91_RS17325 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G3W91_RS17340 ENOG4105CXN decarboxylase G3W91_RS17370 ENOG4105CP9 extracellular ligand-binding receptor G3W91_RS17385 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G3W91_RS17405 ENOG4107R11 Transcriptional regulator G3W91_RS17410 ENOG4105CHM Aminotransferase G3W91_RS17420 ENOG4105CQ7 ATP-dependent helicase G3W91_RS17425 ENOG4108EKC n-acetylglutamate synthase G3W91_RS17430 ENOG4105CHM Aminotransferase G3W91_RS17435 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) G3W91_RS17440 ENOG4105CZX twitching motility protein G3W91_RS17445 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G3W91_RS17450 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) G3W91_RS17455 ENOG4105C5H ABC transporter G3W91_RS17485 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G3W91_RS17490 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) G3W91_RS17500 ENOG4105E2X shikimate dehydrogenase G3W91_RS17515 ENOG4107EFR Flavocytochrome c G3W91_RS17520 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS17555 ENOG4105CHR reductase G3W91_RS17565 ENOG4105CHR reductase G3W91_RS17575 ENOG4105C0Z ABC transporter G3W91_RS17580 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS17590 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS17595 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G3W91_RS17625 ENOG4108FUF Transcriptional regulator, IclR family G3W91_RS17635 ENOG4105D7T ABC transporter G3W91_RS17640 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W91_RS17650 ENOG4107QSA Oxaloacetate decarboxylase G3W91_RS17655 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G3W91_RS17670 ENOG4105CHR reductase G3W91_RS17690 ENOG4105CUZ uba thif-type nad fad binding protein G3W91_RS17700 ENOG4105KCK Peptidoglycan-associated lipoprotein G3W91_RS17705 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) G3W91_RS17710 ENOG4105BZ1 (ABC) transporter G3W91_RS17720 ENOG4105C03 ribonuclease G3W91_RS17725 ENOG4108Z03 MAF-like protein G3W91_RS17730 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) G3W91_RS17735 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G3W91_RS17740 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G3W91_RS17745 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) G3W91_RS17750 ENOG4105C12 Phosphoribosylglycinamide synthetase G3W91_RS17755 ENOG4105CDY transcriptional regulatory protein G3W91_RS17780 ENOG4105C2D reductase G3W91_RS17795 ENOG4108ZJ4 polysaccharide deacetylase G3W91_RS17815 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) G3W91_RS17830 ENOG4105D7A ATP-binding protein G3W91_RS17835 ENOG4108ZJD Protein of unknown function (DUF1109) G3W91_RS17840 ENOG4105NCT RNA Polymerase G3W91_RS17850 ENOG4105E18 UPF0276 protein G3W91_RS17875 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G3W91_RS17880 ENOG4107TFB basic membrane G3W91_RS17885 ENOG4108JQ9 ABC transporter G3W91_RS17890 ENOG4105UIB (ABC) transporter G3W91_RS17900 ENOG4105DZC cytosine deaminase G3W91_RS17905 ENOG4105CJB Exodeoxyribonuclease I G3W91_RS17910 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G3W91_RS17915 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3W91_RS17920 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G3W91_RS17940 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G3W91_RS17945 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G3W91_RS17955 ENOG4108ZZF transport protein (ExbD) G3W91_RS17960 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) G3W91_RS17965 ENOG4105W49 UPF0434 protein G3W91_RS17970 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) G3W91_RS17975 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G3W91_RS17990 ENOG4107RB3 L-asparaginase G3W91_RS17995 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G3W91_RS18005 ENOG4108JQ1 Dehydrogenase G3W91_RS18010 ENOG4105F27 Major Facilitator G3W91_RS18020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W91_RS18025 ENOG4108UKI Enoyl-CoA hydratase G3W91_RS18050 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G3W91_RS18060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W91_RS18065 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) G3W91_RS18070 ENOG4105HBR Rna-binding protein G3W91_RS18085 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G3W91_RS18095 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G3W91_RS18110 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G3W91_RS18115 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3W91_RS18120 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3W91_RS18125 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) G3W91_RS18130 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3W91_RS18140 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G3W91_RS18145 ENOG4105DZP Membrane-associated zinc metalloprotease G3W91_RS18150 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G3W91_RS18155 ENOG4105KNE Phosphatidate cytidylyltransferase G3W91_RS18160 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G3W91_RS18165 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G3W91_RS18170 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G3W91_RS18175 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) G3W91_RS18180 ENOG4105CE9 30S ribosomal protein S2 G3W91_RS18190 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W91_RS18195 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G3W91_RS18200 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3W91_RS18205 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G3W91_RS18215 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) G3W91_RS18220 ENOG4108NVM synthesis repressor PhaR G3W91_RS18235 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3W91_RS18240 ENOG4105DTD Dehydrogenase G3W91_RS18260 ENOG4105E0F Histidine kinase G3W91_RS18265 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) G3W91_RS18270 ENOG4108ECM Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) G3W91_RS18275 ENOG4108JA2 transcriptioN-repair coupling factor G3W91_RS18280 ENOG4105EAC phosphoserine phosphatase G3W91_RS18305 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W91_RS18310 ENOG4105CSM endonuclease III G3W91_RS18315 ENOG4108PGP mmge prpd family protein G3W91_RS18325 ENOG4108UKI Enoyl-CoA hydratase G3W91_RS18345 ENOG4108YIQ Alpha beta hydrolase G3W91_RS18355 ENOG4105GAK amidohydrolase 2 G3W91_RS18360 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G3W91_RS18385 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) G3W91_RS18390 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G3W91_RS18395 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G3W91_RS18415 ENOG4105C1P efflux transporter, rnd family, mfp subunit G3W91_RS18430 ENOG4105CIH Imidazole acetol-phosphate transaminase G3W91_RS18435 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) G3W91_RS18440 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G3W91_RS18445 ENOG4105E0A ABC, transporter G3W91_RS18450 ENOG4105EHG Permease protein G3W91_RS18460 ENOG4108YZT Adenosylcobinamide kinase G3W91_RS18465 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G3W91_RS18480 ENOG4105HF0 Membrane G3W91_RS18495 ENOG4105ES4 Nitrilase G3W91_RS18505 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS18525 ENOG4105DRR Transcriptional regulator, GntR family G3W91_RS18535 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) G3W91_RS18540 ENOG4106NZI LysR family Transcriptional regulator G3W91_RS18545 ENOG4105C01 Dihydroxy-acid dehydratase G3W91_RS18570 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) G3W91_RS18575 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G3W91_RS18595 ENOG4105EUR Domain-Containing protein G3W91_RS18610 ENOG4105DQE DNA ligase G3W91_RS18660 ENOG4105C0H protease G3W91_RS18665 ENOG4105DHQ Histidine kinase G3W91_RS18670 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3W91_RS18675 ENOG4107HP6 Transcriptional regulator G3W91_RS18680 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase G3W91_RS18690 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) G3W91_RS18695 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate G3W91_RS18700 ENOG41069M3 Transcriptional regulator G3W91_RS18705 ENOG41061WM D-Alanyl-D-Alanine G3W91_RS18710 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G3W91_RS18715 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G3W91_RS18720 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G3W91_RS18725 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G3W91_RS18730 ENOG4108ZP8 Acetolactate synthase small subunit G3W91_RS18735 ENOG4105C7K acetolactate synthase G3W91_RS18760 ENOG41080IJ Diacylglycerol kinase G3W91_RS18765 ENOG4108URH decarboxylase G3W91_RS18770 ENOG4108YZA Nitrogen regulatory protein pii G3W91_RS18775 ENOG4105FDR Membrane G3W91_RS18785 ENOG4105CHR reductase G3W91_RS18790 ENOG4105CPQ Dehydrogenase G3W91_RS18795 ENOG4105F0N pyrophosphate phospho-hydrolase G3W91_RS18835 ENOG4107RZC phospholipase d G3W91_RS18855 ENOG4108JQ1 Dehydrogenase G3W91_RS18860 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G3W91_RS18870 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS18895 ENOG4105MP9 class II Aldolase G3W91_RS18900 ENOG4105FP9 thiamine pyrophosphate G3W91_RS18905 ENOG4105C26 Dehydrogenase G3W91_RS18925 ENOG4108UKV benzoate 1,2-dioxygenase G3W91_RS19095 ENOG4108JUA Transcriptional regulator G3W91_RS19100 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G3W91_RS19105 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G3W91_RS19110 ENOG4105CVM Molybdenum cofactor synthesis domain protein G3W91_RS19120 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G3W91_RS19130 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G3W91_RS19135 ENOG4105E9H Lytic Murein transglycosylase G3W91_RS19140 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3W91_RS19150 ENOG4105D2X ABC transporter substrate-binding protein G3W91_RS19160 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G3W91_RS19165 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G3W91_RS19170 ENOG4107QMP dna polymerase iii subunits gamma and tau G3W91_RS19190 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3W91_RS19195 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation G3W91_RS19200 ENOG4105K63 Thioredoxin G3W91_RS19205 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G3W91_RS19210 ENOG4105D9R oxidoreductase G3W91_RS19215 ENOG4105NRA 50s ribosomal protein l31 type b G3W91_RS19225 ENOG4107QI1 Mate efflux family protein G3W91_RS19230 ENOG4105BZU Histidine kinase G3W91_RS19235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W91_RS19245 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G3W91_RS19250 ENOG4105E2Z phosphate ABC transporter (Permease G3W91_RS19255 ENOG4105C8U phosphate abc transporter G3W91_RS19260 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G3W91_RS19265 ENOG4105C9X ppx gppa phosphatase G3W91_RS19285 ENOG4108JU3 Alkyl hydroperoxide reductase G3W91_RS19290 ENOG4105CYM Glutathione S-transferase G3W91_RS19315 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS19320 ENOG4108M9J MaoC like domain protein G3W91_RS19330 ENOG4108QG2 Membrane G3W91_RS19345 ENOG41060WC Enoyl-CoA hydratase G3W91_RS19355 ENOG4105K6S Short-chain dehydrogenase reductase Sdr G3W91_RS19360 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F G3W91_RS19385 ENOG4107YZX Universal stress protein G3W91_RS19395 ENOG4105CCT upf0313 protein G3W91_RS19400 ENOG410645S MarR family Transcriptional regulator G3W91_RS19425 ENOG4107S2Z UPF0761 membrane protein G3W91_RS19440 ENOG4105CPC Aldo Keto reductase G3W91_RS19465 ENOG4105C2N RNA methyltransferase TrmH family group 3 G3W91_RS19470 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3W91_RS19475 ENOG4108UJV acyl-CoA thioesterase i G3W91_RS19485 ENOG4105C28 cystathionine G3W91_RS19500 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G3W91_RS19505 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) G3W91_RS19515 ENOG4105EPW hflc protein G3W91_RS19520 ENOG4107QJR hflk protein G3W91_RS19525 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G3W91_RS19530 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) G3W91_RS19535 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G3W91_RS19540 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G3W91_RS19550 ENOG4105CUT histidyl-tRNA synthetase G3W91_RS19555 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G3W91_RS19570 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G3W91_RS19575 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G3W91_RS19580 ENOG4105FE9 pseudouridine synthase G3W91_RS19585 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G3W91_RS19590 ENOG4105C34 Pseudouridine synthase G3W91_RS19595 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G3W91_RS19600 ENOG4105DVT helicase G3W91_RS19620 ENOG4105D6Z AFG1 family ATPase G3W91_RS19625 ENOG4107QN2 dihydrolipoyl dehydrogenase G3W91_RS19630 ENOG4105C7S Dehydrogenase G3W91_RS19635 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G3W91_RS19640 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3W91_RS19645 ENOG4105DUM transcriptional regulator, lysR family G3W91_RS19655 ENOG4105C26 Dehydrogenase G3W91_RS19680 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G3W91_RS19685 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G3W91_RS19690 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W91_RS19700 ENOG4105CSH Transporter G3W91_RS19720 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W91_RS19725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W91_RS19730 ENOG4105BZU Histidine kinase G3W91_RS19735 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W91_RS19740 ENOG4105BZU Histidine kinase G3W91_RS19750 ENOG4105D58 Diguanylate phosphodiesterase G3W91_RS19785 ENOG4108JQ7 (ABC) transporter G3W91_RS19795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W91_RS19800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G3W91_RS19830 ENOG4108TN6 type iii secretion G3W91_RS19840 ENOG4108JIR Flagellum-specific ATP synthase G3W91_RS19855 ENOG4107Y59 type iii secretion G3W91_RS19900 ENOG4105CB2 alcohol dehydrogenase G3W91_RS19915 ENOG4105F27 Major Facilitator G3W91_RS19940 ENOG4105ERH Fumarylacetoacetate hydrolase G3W91_RS19950 ENOG4108YYH Nadph-dependent fmn reductase G3W91_RS19985 ENOG4107Z7P Ferredoxin G3W91_RS19995 ENOG4105CAD extracellular ligand-binding receptor G3W91_RS20010 ENOG4105C0Z ABC transporter G3W91_RS20015 ENOG4108IV0 ABC, transporter G3W91_RS20030 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS20035 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS20045 ENOG4105FDP GntR family transcriptional regulator G3W91_RS20090 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS20095 ENOG4108WYP Transcriptional regulator G3W91_RS20105 ENOG4108IY8 ABC, transporter G3W91_RS20110 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W91_RS20120 ENOG41082A2 Alpha beta hydrolase G3W91_RS20135 ENOG4105ER2 Ompa motb domain protein G3W91_RS20155 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3W91_RS20160 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G3W91_RS20170 ENOG4105D8V Glucose sorbosone dehydrogenase G3W91_RS20175 ENOG4105K4H Nlp p60 protein G3W91_RS20180 ENOG4107QN2 dihydrolipoyl dehydrogenase G3W91_RS20185 ENOG4107QSN dihydrolipoamide acetyltransferase G3W91_RS20190 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G3W91_RS20195 ENOG4105BZU Histidine kinase G3W91_RS20200 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W91_RS20205 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G3W91_RS20210 ENOG4105DGW oligopeptidase A G3W91_RS20220 ENOG4105E66 phosphoriboisomerase A G3W91_RS20225 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G3W91_RS20240 ENOG4105D5U fad dependent oxidoreductase G3W91_RS20255 ENOG4107RZZ dna polymerase iii epsilon subunit G3W91_RS20260 ENOG4108ZIT Ferredoxin, 2FE-2S G3W91_RS20265 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB G3W91_RS20280 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins G3W91_RS20285 ENOG4105C3J Cysteine desulfurase G3W91_RS20290 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family G3W91_RS20300 ENOG4105CGF Aromatic amino acid aminotransferase G3W91_RS20310 ENOG4108R3D Electron transport complex G3W91_RS20335 ENOG4105DJT lAO AO transport system ATPase G3W91_RS20345 ENOG4105DRR Transcriptional regulator, GntR family G3W91_RS20365 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G3W91_RS20370 ENOG4107QRT dEAD DEAH box helicase G3W91_RS20375 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W91_RS20415 ENOG4105CKD glutathione-regulated potassium-efflux system protein G3W91_RS20420 ENOG4105CHR reductase G3W91_RS20430 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS20435 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class G3W91_RS20445 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G3W91_RS20465 ENOG4108RH0 Crea protein G3W91_RS20475 ENOG4108K5P (LipO)protein G3W91_RS20480 ENOG4107RZC phospholipase d G3W91_RS20495 ENOG4105F04 LysR family Transcriptional regulator G3W91_RS20500 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3W91_RS20550 ENOG4107RSM transcriptional regulator G3W91_RS20555 ENOG4105CHR reductase G3W91_RS20565 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS20570 ENOG4108IV0 ABC, transporter G3W91_RS20575 ENOG4105C0Z ABC transporter G3W91_RS20600 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase G3W91_RS20640 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3W91_RS20675 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS20680 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS20700 ENOG4105BZU Histidine kinase G3W91_RS20710 ENOG4105EQ2 LysR family Transcriptional regulator G3W91_RS20740 ENOG41061N2 exported protein G3W91_RS20745 ENOG4105R1U AraC Family Transcriptional Regulator G3W91_RS20755 ENOG4108K3A Glutathione S-transferase G3W91_RS20770 ENOG4105EUB pirin domain protein G3W91_RS20795 ENOG4108K3A Glutathione S-transferase G3W91_RS20830 ENOG4108YYC ycei family G3W91_RS20835 ENOG4108ZHJ Organic hydroperoxide resistance protein G3W91_RS20840 ENOG4105CH6 catalase G3W91_RS20845 ENOG4105HEI LysR family (Transcriptional regulator G3W91_RS20850 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr G3W91_RS20860 ENOG4105EXC Acyl-transferase G3W91_RS20885 ENOG4105CSU acyl-Coa dehydrogenase G3W91_RS20945 ENOG4108UAU isochorismatase G3W91_RS20955 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS20965 ENOG4105C0Z ABC transporter G3W91_RS20970 ENOG4108IV0 ABC, transporter G3W91_RS20975 ENOG4105ETT transcriptional Regulator, LysR family G3W91_RS21000 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS21005 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS21020 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS21035 ENOG4105CHR reductase G3W91_RS21040 ENOG4105R1U AraC Family Transcriptional Regulator G3W91_RS21045 ENOG4105DSW Fusaric acid resistance protein G3W91_RS21055 ENOG4105Y49 secretion protein, HlyD family G3W91_RS21065 ENOG4105EXG Transcriptional regulator G3W91_RS21095 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS21105 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS21110 ENOG4105CC9 acyl-Coa dehydrogenase G3W91_RS21115 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G3W91_RS21150 ENOG4107258 Transcriptional regulator G3W91_RS21185 ENOG4108UAU isochorismatase G3W91_RS21215 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS21225 ENOG4105DND Transcriptional regulator G3W91_RS21255 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G3W91_RS21265 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G3W91_RS21270 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G3W91_RS21275 ENOG4105VJV 50s ribosomal protein L35 G3W91_RS21280 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G3W91_RS21285 ENOG4105C22 threonyL-tRNA synthetase G3W91_RS21300 ENOG4108I9X Isocitrate lyase G3W91_RS21325 ENOG4108W9H Tetr family transcriptional regulator G3W91_RS21370 ENOG4107TTA Xylose isomerase domain protein TIM barrel G3W91_RS21390 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G3W91_RS21420 ENOG4105CHH sulfate transporter G3W91_RS21425 ENOG4108YZN class I peptide chain release factor G3W91_RS21440 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3W91_RS21460 ENOG4106NZI LysR family Transcriptional regulator G3W91_RS21470 ENOG4108ZAF Molybdopterin G3W91_RS21480 ENOG4105M00 molybdopterin converting factor, subunit 1 G3W91_RS21485 ENOG4105CVM Molybdenum cofactor synthesis domain protein G3W91_RS21490 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b G3W91_RS21495 ENOG4105D98 threonine synthase G3W91_RS21500 ENOG4105D6E homoserine dehydrogenase G3W91_RS21505 ENOG4105CHM Aminotransferase G3W91_RS21515 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G3W91_RS21520 ENOG4108IAB Phoh family G3W91_RS21535 ENOG4105CDU Replicative dna helicase G3W91_RS21540 ENOG4105K9Q Binds to the 23S rRNA (By similarity) G3W91_RS21545 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G3W91_RS21555 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) G3W91_RS21565 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G3W91_RS21570 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) G3W91_RS21575 ENOG4108JU3 Alkyl hydroperoxide reductase G3W91_RS21580 ENOG4105D3R alkyl hydroperoxide reductase G3W91_RS21585 ENOG4108UQY Iron-storage protein G3W91_RS21595 ENOG4105HB4 Pathways of utilization of iron bound to transferrin, lactoferrin and hemoglobin but not to haemin or citrate where dependent on the TonB system G3W91_RS21605 ENOG4105M8F Biopolymer transport protein exbD tolR G3W91_RS21615 ENOG4108ZJF Glcg protein G3W91_RS21620 ENOG4108MN8 Membrane G3W91_RS21625 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G3W91_RS21630 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W91_RS21635 ENOG4108K5P (LipO)protein G3W91_RS21640 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G3W91_RS21645 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) G3W91_RS21665 ENOG4107TF3 peptidylprolyl cis-trans isomerase G3W91_RS21680 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3W91_RS21685 ENOG4105EBM Alpha Beta Hydrolase Fold protein G3W91_RS21690 ENOG4105EJC lysr family transcriptional regulator G3W91_RS21745 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G3W91_RS21755 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G3W91_RS21775 ENOG4105C5I Dehydrogenase G3W91_RS21785 ENOG4107RH7 Nicotinate phosphoribosyltransferase G3W91_RS21790 ENOG4105VDW Csbd family G3W91_RS21805 ENOG4105DGU Histone deacetylase G3W91_RS21810 ENOG4108WFY phasin family G3W91_RS21820 ENOG4107S2Z UPF0761 membrane protein G3W91_RS21825 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G3W91_RS21830 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W91_RS21835 ENOG4105C2C drug resistance transporter, Bcr CflA G3W91_RS21850 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS21855 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W91_RS21865 ENOG4105EJC lysr family transcriptional regulator G3W91_RS21870 ENOG4108RYK Nad-dependent epimerase dehydratase G3W91_RS21885 ENOG4108IV0 ABC, transporter G3W91_RS21890 ENOG4105C0Z ABC transporter G3W91_RS21915 ENOG4108WYP Transcriptional regulator G3W91_RS21935 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G3W91_RS21950 ENOG4105E90 ABC transporter G3W91_RS21955 ENOG4105C26 Dehydrogenase G3W91_RS21960 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase G3W91_RS21970 ENOG4107YCY Transcriptional regulator G3W91_RS21975 ENOG4105E9Z Nad-dependent epimerase dehydratase G3W91_RS21985 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G3W91_RS21995 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS22000 ENOG4105CTX dehydratase G3W91_RS22015 ENOG4105DJ4 phosphatidylserine decarboxylase G3W91_RS22025 ENOG4108V1T peptidylprolyl cis-trans isomerase G3W91_RS22030 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G3W91_RS22035 ENOG4105CFG Acts as a chaperone (By similarity) G3W91_RS22040 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G3W91_RS22045 ENOG41073TP transcriptional regulator G3W91_RS22050 ENOG4105ERH Fumarylacetoacetate hydrolase G3W91_RS22060 ENOG4105CYN Serine protein kinase G3W91_RS22065 ENOG4106AKX UPF0229 protein G3W91_RS22070 ENOG4105ED1 spovr family G3W91_RS22075 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS22105 ENOG4108R3E Dna-3-methyladenine glycosylase i G3W91_RS22110 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G3W91_RS22115 ENOG4105ETE Transcriptional regulator (LacI family G3W91_RS22130 ENOG4107YCY Transcriptional regulator G3W91_RS22155 ENOG4107QPD alcohol dehydrogenase G3W91_RS22185 ENOG4107QX3 carboxylase G3W91_RS22205 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3W91_RS22225 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3W91_RS22235 ENOG4107RZC phospholipase d G3W91_RS22250 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G3W91_RS22255 ENOG4105K4T epimerase G3W91_RS22260 ENOG4105K63 Thioredoxin G3W91_RS22265 ENOG4107S2Z UPF0761 membrane protein G3W91_RS22275 ENOG4105CQB FAD linked oxidase domain protein G3W91_RS22305 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) G3W91_RS22340 ENOG4105CFF transcriptional regulator G3W91_RS22350 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) G3W91_RS22415 ENOG4105CGK Exodeoxyribonuclease III G3W91_RS22425 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W91_RS22430 ENOG4105CUX Signal transduction histidine kinase G3W91_RS22445 ENOG4107TH8 cina domain protein G3W91_RS22470 ENOG4105I08 Pseudouridine synthase G3W91_RS22480 ENOG4106R49 Methyltransferase G3W91_RS22495 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G3W91_RS22500 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G3W91_RS22505 ENOG4105UYK outer membrane protein a G3W91_RS22510 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W91_RS22520 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G3W91_RS22525 ENOG4105CQC Prephenate dehydratase G3W91_RS22535 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G3W91_RS22540 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G3W91_RS22555 ENOG4105CFV Tetratricopeptide repeat protein G3W91_RS22575 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS22580 ENOG4107Z6W Protein CrcB homolog G3W91_RS22585 ENOG4105D65 subunit l G3W91_RS22590 ENOG4108ZE9 Monovalent cation H antiporter subunit C G3W91_RS22595 ENOG4107R4Z monovalent cation h antiporter subunit d G3W91_RS22605 ENOG4105W4C monovalent cation H antiporter subunit F G3W91_RS22610 ENOG4105KJM monovalent cation h antiporter subunit g G3W91_RS22655 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G3W91_RS22690 ENOG4108YYC ycei family G3W91_RS22705 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family G3W91_RS22720 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G3W91_RS22750 ENOG4108IJ0 Aspartate ammonia-lyase G3W91_RS22770 ENOG4105F4R Transcriptional regulator mode G3W91_RS22775 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G3W91_RS22780 ENOG4105E0C molybdate abc transporter G3W91_RS22785 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G3W91_RS22795 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G3W91_RS22800 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W91_RS22825 ENOG4105F4R Transcriptional regulator mode G3W91_RS22845 ENOG4108IV0 ABC, transporter G3W91_RS22850 ENOG4105C0Z ABC transporter G3W91_RS22865 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G3W91_RS22870 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit G3W91_RS22875 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit G3W91_RS22880 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit G3W91_RS22885 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit G3W91_RS22895 ENOG4108ZJI phenylacetic acid degradation protein G3W91_RS22900 ENOG4108UKI Enoyl-CoA hydratase G3W91_RS22905 ENOG4108Z0R Transferase G3W91_RS22910 ENOG4108IG5 Transcriptional regulator G3W91_RS22915 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G3W91_RS22935 ENOG4105CH5 extracellular solute-binding protein, family 7 G3W91_RS22940 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) G3W91_RS22950 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G3W91_RS22965 ENOG4105KHC sulfurtransferase G3W91_RS22975 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3W91_RS22990 ENOG4105WKW Pfam:DUF1458 G3W91_RS23005 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) G3W91_RS23015 ENOG4107RP9 extracellular solute-binding protein, family 3 G3W91_RS23020 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W91_RS23035 ENOG4105C2M dna polymerase I G3W91_RS23045 ENOG4105CUV Homoserine Kinase G3W91_RS23055 ENOG4105C4R Atp-dependent dna helicase G3W91_RS23070 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) G3W91_RS23085 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS23100 ENOG4105C1J atp-dependent rna helicase G3W91_RS23105 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) G3W91_RS23110 ENOG4105D0M Protease HtpX homolog G3W91_RS23115 ENOG41090A4 Pterin carbinolamine dehydratase G3W91_RS23120 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G3W91_RS23125 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G3W91_RS23130 ENOG4105CIH Imidazole acetol-phosphate transaminase G3W91_RS23135 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) G3W91_RS23145 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G3W91_RS23150 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) G3W91_RS23155 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G3W91_RS23160 ENOG4105K5M 30s ribosomal protein S16 G3W91_RS23175 ENOG4107QXV Phosphate transporter G3W91_RS23180 ENOG4107GRR phosphate transport regulator G3W91_RS23185 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G3W91_RS23190 ENOG4105DJ0 Poly(A) Polymerase G3W91_RS23195 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) G3W91_RS23200 ENOG4105CXB phosphoribosylaminoimidazole synthetase G3W91_RS23205 ENOG4106F5Q Membrane G3W91_RS23220 ENOG4105E2K Glycosyl transferase (Group 1 G3W91_RS23240 ENOG4105CJR Integral membrane protein (MviN G3W91_RS23245 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) G3W91_RS23255 ENOG4105C8Y Acetylornithine aminotransferase G3W91_RS23260 ENOG4105DBV ornithine carbamoyltransferase G3W91_RS23265 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) G3W91_RS23275 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) G3W91_RS23320 ENOG4105MSY salicylate hydroxylase G3W91_RS23330 ENOG4105CE1 Ferrous iron transport protein b G3W91_RS23345 ENOG4107QM5 aconitate hydratase G3W91_RS23360 ENOG4107QIJ Aconitate hydratase 2 G3W91_RS23375 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) G3W91_RS23380 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G3W91_RS23385 ENOG4105FDP GntR family transcriptional regulator G3W91_RS23400 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G3W91_RS23405 ENOG4105E33 succinate dehydrogenase G3W91_RS23410 ENOG41060IS Flavinator of succinate dehydrogenase G3W91_RS23415 ENOG4105BZN citrate synthase G3W91_RS23430 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS23435 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS23440 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3W91_RS23445 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G3W91_RS23455 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) G3W91_RS23460 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase G3W91_RS23465 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G3W91_RS23470 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G3W91_RS23475 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) G3W91_RS23480 ENOG4108VIA integral membrane protein G3W91_RS23490 ENOG4105CRK lysyL-tRNA synthetase G3W91_RS23495 ENOG4105R8A Heat shock protein G3W91_RS23500 ENOG4108VKG metal-dependent hydrolase G3W91_RS23505 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) G3W91_RS23510 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) G3W91_RS23515 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) G3W91_RS23520 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) G3W91_RS23525 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G3W91_RS23530 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G3W91_RS23540 ENOG4105C3F Signal peptidase i G3W91_RS23545 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G3W91_RS23550 ENOG4105C0H protease G3W91_RS23565 ENOG4105EMN RNA polymerase sigma factor G3W91_RS23570 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G3W91_RS23575 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G3W91_RS23580 ENOG4105CHR reductase G3W91_RS23585 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G3W91_RS23590 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G3W91_RS23595 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) G3W91_RS23600 ENOG4105VGS 50s ribosomal protein l32 G3W91_RS23605 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein G3W91_RS23610 ENOG4108UHJ MAF-like protein G3W91_RS23615 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G3W91_RS23620 ENOG4106UW1 Major Facilitator superfamily G3W91_RS23625 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G3W91_RS23640 ENOG4105EI2 Pseudouridine synthase G3W91_RS23645 ENOG4105C03 ribonuclease G3W91_RS23650 ENOG4105D3Q Sugar transferase G3W91_RS23655 ENOG4105CJT Mannose-1-phosphate guanylyltransferase G3W91_RS23660 ENOG4105C30 Nad-dependent epimerase dehydratase G3W91_RS23680 ENOG4106CD9 glycosyl transferase group 1 G3W91_RS23715 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G3W91_RS23720 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) G3W91_RS23725 ENOG410642W LysR family Transcriptional regulator G3W91_RS23730 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G3W91_RS23770 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) G3W91_RS23785 ENOG4105D1Q UPF0246 protein G3W91_RS23795 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G3W91_RS23805 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) G3W91_RS23815 ENOG4105C6T cysteine synthase G3W91_RS23825 ENOG4105VFU Rna-binding protein G3W91_RS23835 ENOG4105C26 Dehydrogenase G3W91_RS23845 ENOG4108UAJ Transcriptional regulator G3W91_RS23850 ENOG4105C0H protease G3W91_RS23875 ENOG4108IV0 ABC, transporter G3W91_RS23880 ENOG4105C0Z ABC transporter G3W91_RS23885 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G3W91_RS23890 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS23895 ENOG4105D1H recombination factor protein RarA G3W91_RS23900 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) G3W91_RS23905 ENOG4105CNU cell division protein FtsK G3W91_RS23915 ENOG4105C3M thioredoxin reductase G3W91_RS23920 ENOG4105KDC 50s ribosomal protein l28 G3W91_RS23925 ENOG4105W0E 50S ribosomal protein L33 G3W91_RS23955 ENOG4108V3E phosphoribosylglycinamide formyltransferase G3W91_RS23960 ENOG4105X7H acyl-CoA dehydrogenase G3W91_RS23965 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS23975 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS23985 ENOG4105DTN riboflavin biosynthesis protein ribF G3W91_RS23995 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G3W91_RS24000 ENOG4105EAM Na Pi-cotransporter G3W91_RS24005 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3W91_RS24020 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3W91_RS24025 ENOG4108JQ7 (ABC) transporter G3W91_RS24040 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3W91_RS24045 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein G3W91_RS24050 ENOG4105JQN Transcriptional regulator G3W91_RS24055 ENOG4105CHR reductase G3W91_RS24065 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G3W91_RS24085 ENOG4107QHF type ii secretion system protein e G3W91_RS24090 ENOG4105I7M spermidine synthase G3W91_RS24105 ENOG4105EYA deoxyribonuclease G3W91_RS24110 ENOG4105C0H protease G3W91_RS24115 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G3W91_RS24135 ENOG4105RQF LysR family Transcriptional regulator G3W91_RS24145 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G3W91_RS24170 ENOG4105CAF HipA N-terminal domain protein G3W91_RS24180 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3W91_RS24195 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G3W91_RS24215 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G3W91_RS24220 ENOG4105BZU Histidine kinase G3W91_RS24225 ENOG4108YZ9 Urea amidohydrolase subunit gamma G3W91_RS24235 ENOG4105KI2 Urea amidohydrolase subunit beta G3W91_RS24240 ENOG4105CQM Urea amidohydrolase subunit alpha G3W91_RS24250 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) G3W91_RS24255 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G3W91_RS24260 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) G3W91_RS24270 ENOG4105C7K acetolactate synthase G3W91_RS24320 ENOG4105CSA Coproporphyrinogen iii oxidase G3W91_RS24325 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G3W91_RS24330 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G3W91_RS24340 ENOG4105D9P serine threonine protein kinase G3W91_RS24345 ENOG4105DSJ YicC domain protein G3W91_RS24350 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G3W91_RS24355 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) G3W91_RS24360 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3W91_RS24365 ENOG4108RRZ Transcription elongation factor GreB G3W91_RS24555 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G3W91_RS24625 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G3W91_RS24645 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W91_RS24700 ENOG4105CDA abc transporter atp-binding protein G3W91_RS24710 ENOG4105DRP amino acid AbC transporter G3W91_RS24715 ENOG4105EAD ABC transporter G3W91_RS25150 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G3W91_RS25185 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G3W91_RS25205 ENOG4105ECI YeeC-like protein G3W91_RS25210 ENOG4105F6A helicase G3W91_RS25215 ENOG4105D85 methylase G3W91_RS25235 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G3W91_RS25240 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G3W91_RS25245 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G3W91_RS25250 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G3W91_RS25255 ENOG4105CEN a g-specific adenine glycosylase G3W91_RS25260 ENOG410890F Dynamin family G3W91_RS25265 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G3W91_RS25280 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G3W91_RS25290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G3W91_RS25295 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G3W91_RS25300 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G3W91_RS25310 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G3W91_RS25320 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W91_RS25330 ENOG4108JQ7 (ABC) transporter G3W91_RS25335 ENOG4105DEF Extracellular solute-binding protein, family 5 G3W91_RS25340 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W91_RS25375 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G3W91_RS25380 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G3W91_RS25385 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G3W91_RS25390 ENOG4107QSN dihydrolipoamide acetyltransferase G3W91_RS25395 ENOG4107QN2 dihydrolipoyl dehydrogenase G3W91_RS25400 ENOG4105EV9 Alpha Beta Hydrolase G3W91_RS25405 ENOG4105C6K Malic enzyme G3W91_RS25415 ENOG4105CEP NADH dehydrogenase G3W91_RS25420 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS25425 ENOG4105CHR reductase G3W91_RS25430 ENOG4105CQZ Histidine kinase G3W91_RS25435 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W91_RS25440 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) G3W91_RS25445 ENOG4105E7W lamb ycsf family protein G3W91_RS25450 ENOG4107R7A Allophanate hydrolase subunit 2 G3W91_RS25455 ENOG4105P4J Allophanate hydrolase, subunit 1 G3W91_RS25460 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G3W91_RS25465 ENOG4106H78 methyltransferase G3W91_RS25490 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W91_RS25500 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G3W91_RS25525 ENOG4107QS1 Cytochrome C Oxidase, Subunit III G3W91_RS25535 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) G3W91_RS25540 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3W91_RS25555 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G3W91_RS25565 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G3W91_RS25575 ENOG4105D1F ATP-binding protein G3W91_RS25595 ENOG4105E9F Enoyl-CoA hydratase G3W91_RS25620 ENOG4105CSU acyl-Coa dehydrogenase G3W91_RS25645 ENOG4105E0Y RtcB Protein G3W91_RS25650 ENOG4105CIF Ornithine Cyclodeaminase G3W91_RS25655 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS25660 ENOG4107QNJ CoA-transferase subunit B G3W91_RS25670 ENOG4107HP6 Transcriptional regulator G3W91_RS25690 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W91_RS25695 ENOG4105K70 DNA-binding protein G3W91_RS25725 ENOG4108K2P TRANSCRIPTIONal G3W91_RS25735 ENOG4105ERH Fumarylacetoacetate hydrolase G3W91_RS25745 ENOG4105E2B Taurine dioxygenase G3W91_RS25790 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G3W91_RS25795 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3W91_RS25800 ENOG4105C26 Dehydrogenase G3W91_RS25805 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G3W91_RS25810 ENOG4105EVZ LysR family transcriptional regulator G3W91_RS25815 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G3W91_RS25835 ENOG4105VG5 Membrane G3W91_RS25865 ENOG4105VFU Rna-binding protein G3W91_RS25875 ENOG4105D44 asparaginase G3W91_RS25880 ENOG4108JQ6 ABC transporter G3W91_RS25885 ENOG4105DEF Extracellular solute-binding protein, family 5 G3W91_RS25895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3W91_RS25965 ENOG4108IV0 ABC, transporter G3W91_RS25970 ENOG4108IUZ ABC transporter G3W91_RS25990 ENOG4105C26 Dehydrogenase G3W91_RS26000 ENOG4105G9V cytochrome C G3W91_RS26005 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G3W91_RS26030 ENOG4105DDW LysR family Transcriptional regulator G3W91_RS26045 ENOG4106RE7 Cytochrome G3W91_RS26050 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3W91_RS26200 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G3W91_RS26215 ENOG4108Z20 Acyl-transferase G3W91_RS26220 ENOG4105CD3 dihydroorotase G3W91_RS26225 ENOG4105CXT aspartate transcarbamylase G3W91_RS26230 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G3W91_RS26235 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G3W91_RS26240 ENOG4108UJU UPF0301 protein G3W91_RS26245 ENOG4105CVP deoxyribo-dipyrimidine photolyase G3W91_RS26255 ENOG4105C8Q Methyl-accepting chemotaxis G3W91_RS26265 ENOG4105M3Z response regulator G3W91_RS26270 ENOG4108UNF response regulator G3W91_RS26275 ENOG4105VCQ rubredoxin G3W91_RS26285 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G3W91_RS26290 ENOG4105DC1 bifunctional purine biosynthesis protein purh G3W91_RS26300 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G3W91_RS26305 ENOG4105W39 Membrane G3W91_RS26310 ENOG4105C3G gtp-binding protein G3W91_RS26315 ENOG4105QVC MOSC domain-containing protein G3W91_RS26320 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G3W91_RS26335 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS26375 ENOG4108QBV Monogalactosyldiacylglycerol synthase G3W91_RS26390 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G3W91_RS26395 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase G3W91_RS26400 ENOG4105E8V Alpha Beta Hydrolase Fold protein G3W91_RS26405 ENOG41077RS Phosphatase G3W91_RS26420 ENOG4108HPI phosphatidate Cytidylyltransferase G3W91_RS26425 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) G3W91_RS26430 ENOG4105C9A Phoh family G3W91_RS26435 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) G3W91_RS26440 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) G3W91_RS26465 ENOG4105DR5 peptidase G3W91_RS26470 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G3W91_RS26475 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3W91_RS26480 ENOG4108YX9 iron--sulfur cluster insertion protein erpA G3W91_RS26485 ENOG4108UJD 30S ribosomal protein S9 G3W91_RS26490 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G3W91_RS26495 ENOG4105D6S protein involved in catabolism of external DNA G3W91_RS26505 ENOG4105SYT Methylenetetrahydrofolate reductase G3W91_RS26515 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G3W91_RS26520 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) G3W91_RS26545 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS26550 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G3W91_RS26555 ENOG4105CSH Transporter G3W91_RS26575 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W91_RS26580 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase G3W91_RS26590 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) G3W91_RS26595 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G3W91_RS26600 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G3W91_RS26615 ENOG4108IPT Naphthoate synthase G3W91_RS26625 ENOG4107QX3 carboxylase G3W91_RS26630 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS26635 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS26650 ENOG4107URF beta-phospho-glucomutase G3W91_RS26655 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G3W91_RS26670 ENOG4105K5B UPF0225 protein G3W91_RS26685 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS26695 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS26700 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) G3W91_RS26705 ENOG41077A9 carbonic anhydrase G3W91_RS26710 ENOG4108Z6Z Transcriptional regulator G3W91_RS26725 ENOG4105D3G Pseudouridine synthase G3W91_RS26730 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS26740 ENOG4105CHR reductase G3W91_RS26755 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase G3W91_RS26760 ENOG4105C38 Glycyl-tRNA synthetase beta subunit G3W91_RS26765 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit G3W91_RS26785 ENOG4105CAU Arsenical resistance protein, ArsH G3W91_RS26790 ENOG4105D6J arsenicaL-resistance protein G3W91_RS26830 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3W91_RS26840 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G3W91_RS26845 ENOG4108JU5 Magnesium and cobalt efflux protein G3W91_RS26855 ENOG4105J0Q Transcriptional regulator G3W91_RS26865 ENOG4105F87 Dehydratase G3W91_RS26870 ENOG4105MIR Phenylalanine 4-monooxygenase G3W91_RS26880 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS26910 ENOG4105C5H ABC transporter G3W91_RS26915 ENOG4107RZC phospholipase d G3W91_RS26920 ENOG4105CHM Aminotransferase G3W91_RS26930 ENOG4105T38 integral membrane protein G3W91_RS26935 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3W91_RS26940 ENOG4108NIW Leucine export protein LeuE G3W91_RS26945 ENOG4108TGY Glutathione S-transferase G3W91_RS26950 ENOG4105JAB phenazine biosynthesis protein, phzf family G3W91_RS26975 ENOG4105F4K antigen 43 G3W91_RS26985 ENOG4105VF7 tolerance protein G3W91_RS27000 ENOG4108V1U phospholipid-binding protein G3W91_RS27025 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) G3W91_RS27030 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G3W91_RS27035 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G3W91_RS27040 ENOG4105C25 Primosomal protein n' G3W91_RS27055 ENOG4105RK9 auxin efflux carrier G3W91_RS27060 ENOG4105C4R Atp-dependent dna helicase G3W91_RS27070 ENOG4105HDD phospholipase G3W91_RS27080 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G3W91_RS27130 ENOG4105CHR reductase G3W91_RS27135 ENOG41073TP transcriptional regulator G3W91_RS27140 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS27165 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS27185 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS27210 ENOG4105CC9 acyl-Coa dehydrogenase G3W91_RS27215 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS27220 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS27235 ENOG4105EA8 2-Nitropropane dioxygenase G3W91_RS27250 ENOG4105CPC Aldo Keto reductase G3W91_RS27265 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS27280 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS27290 ENOG4108IV0 ABC, transporter G3W91_RS27295 ENOG4105C0Z ABC transporter G3W91_RS27300 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS27310 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3W91_RS27330 ENOG4105CGU Enoyl-CoA hydratase G3W91_RS27335 ENOG4105CHR reductase G3W91_RS27350 ENOG4105CGU Enoyl-CoA hydratase G3W91_RS27435 ENOG4105ES5 Histidine kinase G3W91_RS27445 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G3W91_RS27455 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G3W91_RS27460 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G3W91_RS27465 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G3W91_RS27470 ENOG4108VZM 50s ribosomal protein L10 G3W91_RS27475 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) G3W91_RS27480 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) G3W91_RS27490 ENOG4105PM1 preprotein translocase subunit SecE G3W91_RS27500 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G3W91_RS27520 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G3W91_RS27525 ENOG4105DK0 Indole-3-glycerol phosphate synthase G3W91_RS27530 ENOG4107QYG anthranilate phosphoribosyltransferase G3W91_RS27535 ENOG410829K Lysine exporter protein (Lyse ygga) G3W91_RS27545 ENOG4105DDQ anthranilate synthase G3W91_RS27570 ENOG4105CHR reductase G3W91_RS27580 ENOG4108IV0 ABC, transporter G3W91_RS27585 ENOG4105C0Z ABC transporter G3W91_RS27590 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS27605 ENOG4105FUY alpha subunit G3W91_RS27620 ENOG4105CHR reductase G3W91_RS27625 ENOG4106IPI cyclase, family G3W91_RS27635 ENOG4105CHU acetyl-coa acetyltransferase G3W91_RS27640 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS27680 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G3W91_RS27690 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3W91_RS27700 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G3W91_RS27725 ENOG4105F4K antigen 43 G3W91_RS27730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W91_RS27800 ENOG4108ZF3 Phosphatase G3W91_RS27830 ENOG4105CS6 Rhs element vgr protein G3W91_RS27835 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G3W91_RS27840 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3W91_RS27875 ENOG4105D9P serine threonine protein kinase G3W91_RS27890 ENOG4106VK6 Flagellar motor protein G3W91_RS27915 ENOG4105CKT filamentous hemagglutinin G3W91_RS27920 ENOG4105D5K Hemolysin activator protein G3W91_RS27925 ENOG4105EHI Phosphonate ABC transporter, periplasmic G3W91_RS27930 ENOG4105EHI Phosphonate ABC transporter, periplasmic G3W91_RS27970 ENOG4105C75 arginyL-tRNA synthetase G3W91_RS27985 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA G3W91_RS27990 ENOG4108IUZ ABC transporter G3W91_RS27995 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3W91_RS28000 ENOG4107RZC phospholipase d G3W91_RS28040 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS28045 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) G3W91_RS28060 ENOG4105C2X Arabinose 5-phosphate isomerase G3W91_RS28065 ENOG4105NVB glycoside hydrolase, family 19 G3W91_RS28080 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G3W91_RS28105 ENOG4108ZAI phosphatidylglycerophosphatase a G3W91_RS28145 ENOG4105DND Transcriptional regulator G3W91_RS28155 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS28160 ENOG4105BZU Histidine kinase G3W91_RS28180 ENOG4108IMY Transcriptional regulator G3W91_RS28185 ENOG4107W7X Aldolase G3W91_RS28190 ENOG4105CH5 extracellular solute-binding protein, family 7 G3W91_RS28200 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G3W91_RS28205 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) G3W91_RS28215 ENOG4105NWN ApaG protein G3W91_RS28220 ENOG4105DJV ribulose-phosphate 3-epimerase G3W91_RS28250 ENOG4108Z9W Outer membrane porin G3W91_RS28255 ENOG4105EB3 Histidine kinase G3W91_RS28260 ENOG4105E3W Two component transcriptional regulator (Winged helix family G3W91_RS28275 ENOG4105DQE DNA ligase G3W91_RS28290 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W91_RS28300 ENOG4105EQX glucarate dehydratase G3W91_RS28310 ENOG4105ETE Transcriptional regulator (LacI family G3W91_RS28340 ENOG4105D5K Hemolysin activator protein G3W91_RS28365 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS28370 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W91_RS28375 ENOG4107258 Transcriptional regulator G3W91_RS28380 ENOG4105CIH Imidazole acetol-phosphate transaminase G3W91_RS28385 ENOG4107QP3 malate synthase g G3W91_RS28410 ENOG4105ETT transcriptional Regulator, LysR family G3W91_RS28420 ENOG4105F2C Acetyl-CoA acetyltransferase G3W91_RS28425 ENOG4108UKI Enoyl-CoA hydratase G3W91_RS28430 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS28450 ENOG4107R15 K00850 6-phosphofructokinase 1 EC 2.7.1.11 G3W91_RS28465 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3W91_RS28470 ENOG4105E7A Glutamine amidotransferase G3W91_RS28480 ENOG4105D7Z glutathione synthase G3W91_RS28485 ENOG4105DKK Benzoate G3W91_RS28490 ENOG4105DFH Transport of potassium into the cell (By similarity) G3W91_RS28500 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G3W91_RS28505 ENOG4105DJF DNA polymerase III, delta' subunit G3W91_RS28515 ENOG4105C8T Leucyl-tRNA synthetase G3W91_RS28520 ENOG4105SG9 biopolymer transport protein, ExbD G3W91_RS28535 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G3W91_RS28540 ENOG41090R7 Ferric uptake G3W91_RS28545 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) G3W91_RS28550 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN G3W91_RS28555 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA G3W91_RS28560 ENOG4105C4R Atp-dependent dna helicase G3W91_RS28565 ENOG4107QUT magnesium and cobalt transport protein CorA G3W91_RS28575 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS28580 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G3W91_RS28585 ENOG4105W8H transhydrogenase (subunit alpha G3W91_RS28590 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G3W91_RS28595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3W91_RS28610 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G3W91_RS28620 ENOG4105DEN Luciferase family G3W91_RS28640 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G3W91_RS28645 ENOG4107WZ3 Transferase G3W91_RS28650 ENOG4105D3Q Sugar transferase G3W91_RS28660 ENOG4105E2K Glycosyl transferase (Group 1 G3W91_RS28680 ENOG4108UUM single-stranded DNA-binding protein G3W91_RS28685 ENOG4105CMQ Chloride channel G3W91_RS28695 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G3W91_RS28700 ENOG4108594 Permease of the drug metabolite transporter G3W91_RS28705 ENOG4105C29 acyl-CoA thioesterase G3W91_RS28725 ENOG4105MSY salicylate hydroxylase G3W91_RS28740 ENOG4108KB2 LysR family Transcriptional regulator G3W91_RS28750 ENOG4105BZU Histidine kinase G3W91_RS28750 ENOG4105BZU Histidine kinase G3W91_RS28760 ENOG4105ETX regulatoR G3W91_RS28765 ENOG4105ERH Fumarylacetoacetate hydrolase G3W91_RS28770 ENOG4105F1J Homogentisate 1,2-dioxygenase G3W91_RS28780 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G3W91_RS28830 ENOG4105SKN orotidine 5''-phosphate decarboxylase G3W91_RS28840 ENOG4105KEG ribosomal-protein-alanine acetyltransferase G3W91_RS28845 ENOG41072GX Peptidase M22 Glycoprotease G3W91_RS28860 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G3W91_RS28865 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G3W91_RS28870 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G3W91_RS28875 ENOG4107QR8 Thioredoxin G3W91_RS28885 ENOG4107RYR Transcriptional regulator, Crp Fnr family G3W91_RS28895 ENOG4105C8V SAICAR synthetase G3W91_RS28905 ENOG4105CA9 Pyruvate kinase G3W91_RS28910 ENOG4105BZA Phosphoglycerate kinase G3W91_RS28915 ENOG4105F04 LysR family Transcriptional regulator G3W91_RS28930 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G3W91_RS28950 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G3W91_RS28960 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G3W91_RS28970 ENOG4105C79 DNA protecting protein DprA G3W91_RS28975 ENOG4108RPN Protein smg homolog G3W91_RS28985 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3W91_RS28990 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3W91_RS28995 ENOG4105VIE preprotein translocase, subunit YajC G3W91_RS29005 ENOG4108YXU transcriptional regulator AsnC family G3W91_RS29010 ENOG4107SFI Major Facilitator superfamily G3W91_RS29015 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family G3W91_RS29020 ENOG4105P52 geranylgeranyl reductase G3W91_RS29050 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) G3W91_RS29055 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3W91_RS29060 ENOG4105FB2 class II Aldolase G3W91_RS29065 ENOG4105G63 Type III effector Hrp-dependent G3W91_RS29070 ENOG4105ZXK Dehydrogenase G3W91_RS29095 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G3W91_RS29105 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G3W91_RS29110 ENOG4105CMV Succinyl-CoA synthetase subunit beta G3W91_RS29120 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS29125 ENOG4105BZU Histidine kinase G3W91_RS29135 ENOG4105CFN oxalyl-CoA decarboxylase G3W91_RS29175 ENOG4105C1J atp-dependent rna helicase G3W91_RS29180 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G3W91_RS29185 ENOG4105C0H protease G3W91_RS29195 ENOG4108Z86 Glutamine amidotransferase G3W91_RS29205 ENOG4105C9U ATP-dependent DNA helicase RecQ G3W91_RS29215 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G3W91_RS29225 ENOG4105DHQ Histidine kinase G3W91_RS29240 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G3W91_RS29245 ENOG4108004 Modulates RecA activity (By similarity) G3W91_RS29250 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G3W91_RS29255 ENOG4105CMV Succinyl-CoA synthetase subunit beta G3W91_RS29260 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G3W91_RS29265 ENOG4108ZCF integral membrane protein G3W91_RS29270 ENOG4108ZF3 Phosphatase G3W91_RS29280 ENOG4105F8J Adenylate Guanylate cyclase G3W91_RS29290 ENOG4105KHS type IV fimbrial pilin protein G3W91_RS29300 ENOG4108YSG O-Antigen polymerase G3W91_RS29330 ENOG4105E2K Glycosyl transferase (Group 1 G3W91_RS29345 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G3W91_RS29390 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G3W91_RS29395 ENOG4105ERG peptidase m48, ste24p G3W91_RS29400 ENOG41086DT Membrane protein of unknown function G3W91_RS29410 ENOG4108ZCF integral membrane protein G3W91_RS29425 ENOG4108VWS Yaeq family G3W91_RS29430 ENOG4107QTF adenylosuccinate lyase G3W91_RS29440 ENOG4108M3P Membrane G3W91_RS29445 ENOG4108U78 Glutathione S-transferase G3W91_RS29460 ENOG4108KPJ rna polymerase sigma factor G3W91_RS29465 ENOG4105K6T rare lipoprotein A G3W91_RS29470 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G3W91_RS29485 ENOG4105BZU Histidine kinase G3W91_RS29490 ENOG4108ZXC Two component transcriptional regulator, luxr family G3W91_RS29520 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G3W91_RS29540 ENOG4108YXU transcriptional regulator AsnC family G3W91_RS29545 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G3W91_RS29550 ENOG4108RZE Tetr family transcriptional regulator G3W91_RS29600 ENOG4105CEV competence damage-inducible protein G3W91_RS29610 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G3W91_RS29615 ENOG4107S2Z UPF0761 membrane protein G3W91_RS29620 ENOG4107R11 Transcriptional regulator G3W91_RS29625 ENOG4107GJV short-chain dehydrogenase reductase G3W91_RS29630 ENOG4107JEE Short-chain dehydrogenase reductase Sdr G3W91_RS29635 ENOG4108YZY peptidylprolyl cis-trans isomerase G3W91_RS29650 ENOG4105EUB pirin domain protein G3W91_RS29675 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS29680 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS29690 ENOG4105ETT transcriptional Regulator, LysR family G3W91_RS29695 ENOG4105F04 LysR family Transcriptional regulator G3W91_RS29705 ENOG4105MSY salicylate hydroxylase G3W91_RS29720 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G3W91_RS29730 ENOG4105ERH Fumarylacetoacetate hydrolase G3W91_RS29735 ENOG4105BZU Histidine kinase G3W91_RS29740 ENOG4105BZU Histidine kinase G3W91_RS29745 ENOG4107Z5C methylesterase G3W91_RS29755 ENOG4105CPC Aldo Keto reductase G3W91_RS29770 ENOG4105EHI Phosphonate ABC transporter, periplasmic G3W91_RS29775 ENOG4105D5T phosphonate abc transporter G3W91_RS29790 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G3W91_RS29810 ENOG4105CJ2 (LipO)protein G3W91_RS29825 ENOG4105FD8 phosphonate metabolism protein PhnM G3W91_RS29830 ENOG4105HRV phosphonate c-p lyase system protein phnl G3W91_RS29835 ENOG4105ENV phosphonate C-P lyase system protein PhnK G3W91_RS29840 ENOG4105FT8 Phosphonate metabolism G3W91_RS29855 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG G3W91_RS29865 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) G3W91_RS29875 ENOG4105CBN LysR family transcriptional regulator G3W91_RS29890 ENOG4105BZU Histidine kinase G3W91_RS29900 ENOG4108UXN response regulator G3W91_RS29935 ENOG4107S2Z UPF0761 membrane protein G3W91_RS29950 ENOG4105JAB phenazine biosynthesis protein, phzf family G3W91_RS29965 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G3W91_RS29995 ENOG4108Z9W Outer membrane porin G3W91_RS30005 ENOG4105CKI cobalamin synthesis protein G3W91_RS30025 ENOG4105ERH Fumarylacetoacetate hydrolase G3W91_RS30030 ENOG41063Z6 transcriptional regulator, lysR family G3W91_RS30045 ENOG4105CSH Transporter G3W91_RS30050 ENOG4106NZI LysR family Transcriptional regulator G3W91_RS30060 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein G3W91_RS30075 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) G3W91_RS30080 ENOG4108IV0 ABC, transporter G3W91_RS30085 ENOG4105C0Z ABC transporter G3W91_RS30090 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS30095 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS30100 ENOG41083Z3 extracellular ligand-binding receptor G3W91_RS30105 ENOG4108WUH Transcriptional regulator, TetR family G3W91_RS30125 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G3W91_RS30135 ENOG4105CR8 Transcriptional regulator G3W91_RS30160 ENOG4105ECQ AraC Family Transcriptional Regulator G3W91_RS30190 ENOG4105DND Transcriptional regulator G3W91_RS30205 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS30220 ENOG4105C32 Amino acid ABC transporter (Permease) G3W91_RS30225 ENOG4105C0Z ABC transporter G3W91_RS30230 ENOG4108IV0 ABC, transporter G3W91_RS30235 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G3W91_RS30245 ENOG4105WEF catalase G3W91_RS30285 ENOG4105C9U ATP-dependent DNA helicase RecQ G3W91_RS30305 ENOG4105EHU Circadian clock protein KaiC G3W91_RS30310 ENOG4105BZU Histidine kinase G3W91_RS30320 ENOG4105HSS phospholipase C G3W91_RS30325 ENOG4105P69 integral membrane protein G3W91_RS30330 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS30335 ENOG4105EGI Transcriptional regulator G3W91_RS30350 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS30360 ENOG4107258 Transcriptional regulator G3W91_RS30370 ENOG4105EMY transcriptional regulator G3W91_RS30375 ENOG4105CHR reductase G3W91_RS30415 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase G3W91_RS30475 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3W91_RS30485 ENOG4105DIA mandelate racemase muconate lactonizing G3W91_RS30495 ENOG4108YAB Invasion protein G3W91_RS30540 ENOG4105C1G acyl-Coa dehydrogenase G3W91_RS30545 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS30550 ENOG4105F04 LysR family Transcriptional regulator G3W91_RS30585 ENOG4105CQB FAD linked oxidase domain protein G3W91_RS30595 ENOG4105C5R Aminotransferase G3W91_RS30615 ENOG4108VX5 3-methyladenine DNA glycosylase G3W91_RS30650 ENOG4105DZR Type I site-specific deoxyribonuclease G3W91_RS30675 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G3W91_RS30680 ENOG4105CV1 Transketolase (EC 2.2.1.1) G3W91_RS30685 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) G3W91_RS30690 ENOG4108S0S Nucleotidyl transferase G3W91_RS30715 ENOG4107RAQ aminopeptidase G3W91_RS30755 ENOG4105C6K Malic enzyme G3W91_RS30770 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G3W91_RS30775 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G3W91_RS30780 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) G3W91_RS30785 ENOG4105EHM Aminoglycoside phosphotransferase G3W91_RS30790 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G3W91_RS30805 ENOG4105DXI Major Facilitator superfamily G3W91_RS30810 ENOG4105E5G Alpha beta hydrolase fold G3W91_RS30830 ENOG4105EYW Ion transport protein G3W91_RS30835 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G3W91_RS30840 ENOG4105DWV Homoserine O-trans-acetylase G3W91_RS30845 ENOG4105DWV Homoserine O-trans-acetylase G3W91_RS30855 ENOG4105VFU Rna-binding protein G3W91_RS30860 ENOG4107FW0 short-chain dehydrogenase reductase G3W91_RS30870 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase G3W91_RS30875 ENOG4105C2X Arabinose 5-phosphate isomerase G3W91_RS30895 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) G3W91_RS30900 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G3W91_RS30905 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G3W91_RS30910 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) G3W91_RS30995 ENOG4105DTN riboflavin biosynthesis protein ribF G3W91_RS31035 ENOG4105D2S major facilitator superfamily G3W91_RS31050 ENOG4108KPJ rna polymerase sigma factor G3W91_RS31055 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G3W91_RS31075 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation G3W91_RS31100 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS31110 ENOG4105EF7 Transcriptional regulator G3W91_RS31130 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS31165 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G3W91_RS31170 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G3W91_RS31175 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3W91_RS31190 ENOG4107258 Transcriptional regulator G3W91_RS31235 ENOG4105JZI cytochrome P450 G3W91_RS31275 ENOG4107AUC G3W91_RS31290 ENOG4105NTD Inherit from COG: Hydrolase G3W91_RS31305 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G3W91_RS31350 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G3W91_RS31360 ENOG4108FUF Transcriptional regulator, IclR family G3W91_RS31370 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3W91_RS31385 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G3W91_RS31445 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS31460 ENOG4105DZS Phenylacetate-CoA ligase G3W91_RS31485 ENOG4105C0Z ABC transporter G3W91_RS31490 ENOG4108IV0 ABC, transporter G3W91_RS31495 ENOG4105CQB FAD linked oxidase domain protein G3W91_RS31500 ENOG4108YXU transcriptional regulator AsnC family G3W91_RS31530 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G3W91_RS31565 ENOG4105ETT transcriptional Regulator, LysR family G3W91_RS31570 ENOG4105ETE Transcriptional regulator (LacI family G3W91_RS31585 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3W91_RS31590 ENOG4105E39 Enoyl-CoA hydratase G3W91_RS31595 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3W91_RS31720 ENOG4105W7K Transcriptional regulator G3W91_RS31755 ENOG4108BUD transposase G3W91_RS31810 ENOG4105C4R Atp-dependent dna helicase G3W91_RS31840 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G3W91_RS31915 ENOG4105C0B DNA polymerase III (alpha subunit) G3W91_RS31985 ENOG4105EP1 Efflux transporter rnd family, mfp subunit G3W91_RS31990 ENOG4108IJF Heavy metal efflux pump, CzcA G3W91_RS32010 ENOG4105E98 transcriptional regulator DeoR family G3W91_RS32015 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G3W91_RS32030 ENOG4105W1Y Transcriptional regulator G3W91_RS32035 ENOG4107SJW iron permease, FTR1 G3W91_RS32060 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3W91_RS32065 ENOG4105CVI Transcriptional regulator G3W91_RS32095 ENOG4107QKA exodeoxyribonuclease V beta G3W91_RS32100 ENOG4105CPB ATP-dependent endonuclease of the OLD family G3W91_RS32160 ENOG4105MZG transcriptional modulator of maze toxin, mazf G3W91_RS32165 ENOG4106A2Z transcriptional regulator antitoxin, MazE G3W91_RS32170 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3W91_RS32175 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G3W91_RS32180 ENOG4106NZI LysR family Transcriptional regulator G3W91_RS32200 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3W91_RS32215 ENOG4105CHR reductase G3W91_RS32225 ENOG4105E5Q amino acid AbC transporter G3W91_RS32230 ENOG4105E5Q amino acid AbC transporter G3W91_RS32255 ENOG4105MP9 class II Aldolase G3W91_RS32260 ENOG41079YP Citrate utilization protein b G3W91_RS32265 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G3W91_RS32275 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W91_RS32295 ENOG4108M0I Transcriptional regulator G3W91_RS32315 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3W91_RS32345 ENOG4107RGD Major Facilitator superfamily G3W91_RS32355 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G3W91_RS32365 ENOG4105EKE dihydroorotase G3W91_RS32375 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G3W91_RS32395 ENOG4107QY8 reductase G3W91_RS32400 ENOG4108JIG Anaerobic dehydrogenase G3W91_RS32435 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G3W91_RS32440 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) G3W91_RS32445 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) G3W91_RS32450 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G3W91_RS32455 ENOG4105CKK Glycosyl transferase, family 2 G3W91_RS32460 ENOG4105C3I Nad-dependent epimerase dehydratase G3W91_RS32470 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) G3W91_RS32480 ENOG4105DIJ Phosphoethanolamine transferase G3W91_RS32535 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3W91_RS32550 ENOG4105CWC Acetylornithine deacetylase G3W91_RS32565 ENOG4105FA0 parb-like partition protein G3W91_RS32620 ENOG4108PCE TRANSFER protein G3W91_RS32625 ENOG4105CMA conjugation trbi family protein G3W91_RS32675 ENOG4105CN1 protease G3W91_RS32685 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) G3W91_RS32705 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G3W91_RS32770 ENOG4105D7T ABC transporter G3W91_RS32775 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3W91_RS32780 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component G3W91_RS32785 ENOG4107XCH Cyclase family G3W91_RS32800 ENOG4105CF7 AraC family transcriptional regulator G3W91_RS32805 ENOG4105CF7 AraC family transcriptional regulator G3W91_RS32835 ENOG4105FDP GntR family transcriptional regulator G3W91_RS32850 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G3W91_RS32855 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS32860 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G3W91_RS32875 ENOG4105CHR reductase G3W91_RS32880 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) G3W91_RS32890 ENOG4105CMM transposase G3W91_RS32945 ENOG4108XM1 transcriptional regulator AsnC family G3W91_RS32965 ENOG4105CDA abc transporter atp-binding protein G3W91_RS33085 ENOG4105CZX twitching motility protein G3W91_RS33100 ENOG4105BZU Histidine kinase G3W91_RS33195 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G3W91_RS33270 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G3W91_RS33570 ENOG4108T9W RNA methylase G3W91_RS33740 ENOG4105EP1 Efflux transporter rnd family, mfp subunit G3W91_RS33745 ENOG4108IJF Heavy metal efflux pump, CzcA G3W91_RS33815 ENOG4105C59 p-type ATPase G3W91_RS33820 ENOG4108Z6Z Transcriptional regulator G3W91_RS33845 ENOG4106RE7 Cytochrome G3W91_RS33850 ENOG4105RQF LysR family Transcriptional regulator G3W91_RS33860 ENOG4105C28 cystathionine G3W91_RS33865 ENOG4107RP9 extracellular solute-binding protein, family 3 G3W91_RS33870 ENOG4105EAD ABC transporter G3W91_RS33875 ENOG4105DRP amino acid AbC transporter G3W91_RS33880 ENOG4105CDA abc transporter atp-binding protein G3W91_RS33915 ENOG4105BZP glycoside hydrolase 15-related G3W91_RS33970 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G3W91_RS34005 ENOG4107RZC phospholipase d G3W91_RS34035 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G3W91_RS34040 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) G3W91_RS34045 ENOG4105CY0 Metallo-Beta-Lactamase G3W91_RS34145 ENOG4105E5H Transposase G3W91_RS34170 ENOG4105CEY Amp-dependent synthetase and ligase G3W91_RS34175 ENOG4105C0W non-ribosomal peptide synthetase G3W91_RS34230 ENOG4108IPJ Membrane G3W91_RS34340 ENOG4105CCU oxidase (Subunit III) G3W91_RS34365 ENOG4105XIV Mercuric transport protein, periplasmic component G3W91_RS34535 ENOG4105K78 MarR family Transcriptional regulator G3W91_RS34540 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G3W91_RS34550 ENOG4105BZU Histidine kinase G3W91_RS34555 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3W91_RS34565 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G3W91_RS34570 ENOG4105QAX Iron-sulfur G3W91_RS34610 ENOG4105EMN RNA polymerase sigma factor G3W91_RS34620 ENOG4105XUA cytochrome c G3W91_RS34625 ENOG4108RG0 uracil-dna glycosylase G3W91_RS34655 ENOG4108J5G 6-phosphogluconate dehydrogenase G3W91_RS34675 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G3W91_RS34710 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W91_RS34715 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3W91_RS34745 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G3W91_RS34770 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G3W91_RS34895 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) G3W91_RS34920 ENOG4105WH1 Two component transcriptional regulator luxr family G3W91_RS34975 ENOG4105D7V transposase G3W91_RS35145 ENOG4105CDU Replicative dna helicase G3W91_RS35170 ENOG41082IR Excinuclease ABC C subunit domain protein G3W91_RS35230 ENOG4105DH7 May be involved in recombination (By similarity) G3W91_RS35280 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G3W91_RS35365 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G3W91_RS35385 ENOG4105FDK ABC transporter